DMGDH

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an enzyme involved in the catabolism of choline, catalyzing the oxidative demethylation of dimethylglycine to form sarcosine. The enzyme is found as a monomer in the mitochondrial matrix, and uses flavin adenine dinucleotide and folate as cofactors. Mutation in this gene causes dimethylglycine dehydrogenase deficiency, characterized by a fishlike body odor, chronic muscle fatigue, and elevated levels of the muscle form of creatine kinase in serum. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1omega-hydroxylase P450 pathway (GO:0097267)8.57257316
2epoxygenase P450 pathway (GO:0019373)8.50566442
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.66132655
4L-phenylalanine catabolic process (GO:0006559)7.66132655
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.33244672
6L-phenylalanine metabolic process (GO:0006558)7.33244672
7aromatic amino acid family catabolic process (GO:0009074)6.96097671
8tryptophan catabolic process (GO:0006569)6.32576858
9indole-containing compound catabolic process (GO:0042436)6.32576858
10indolalkylamine catabolic process (GO:0046218)6.32576858
11oxidative demethylation (GO:0070989)6.32127281
12drug metabolic process (GO:0017144)6.26796228
13triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.18770245
14kynurenine metabolic process (GO:0070189)6.13107595
15bile acid biosynthetic process (GO:0006699)6.01018455
16tryptophan metabolic process (GO:0006568)5.94555109
17glyoxylate metabolic process (GO:0046487)5.87939721
18urea cycle (GO:0000050)5.75703971
19urea metabolic process (GO:0019627)5.75703971
20S-adenosylmethionine metabolic process (GO:0046500)5.56768117
21cysteine metabolic process (GO:0006534)5.56740403
22alpha-linolenic acid metabolic process (GO:0036109)5.51607510
23negative regulation of fibrinolysis (GO:0051918)5.51429825
24sulfur amino acid catabolic process (GO:0000098)5.41844044
25high-density lipoprotein particle remodeling (GO:0034375)5.41075307
26phenylpropanoid metabolic process (GO:0009698)5.34304084
27regulation of fibrinolysis (GO:0051917)5.32585922
28nitrogen cycle metabolic process (GO:0071941)5.30303555
29peptidyl-glutamic acid carboxylation (GO:0017187)5.29594912
30protein carboxylation (GO:0018214)5.29594912
31complement activation, alternative pathway (GO:0006957)5.27729795
32regulation of protein activation cascade (GO:2000257)5.24558708
33ethanol metabolic process (GO:0006067)5.15673289
34bile acid metabolic process (GO:0008206)5.12147977
35aromatic amino acid family metabolic process (GO:0009072)5.08320582
36* serine family amino acid catabolic process (GO:0009071)5.03259940
37homocysteine metabolic process (GO:0050667)5.00613657
38fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.95962291
39regulation of complement activation (GO:0030449)4.89917856
40tyrosine metabolic process (GO:0006570)4.84187492
41regulation of cholesterol esterification (GO:0010872)4.78814036
42lysine metabolic process (GO:0006553)4.78573890
43lysine catabolic process (GO:0006554)4.78573890
44regulation of triglyceride catabolic process (GO:0010896)4.72422420
45* alpha-amino acid catabolic process (GO:1901606)4.70395252
46reverse cholesterol transport (GO:0043691)4.69573264
47regulation of plasminogen activation (GO:0010755)4.65302477
48plasma lipoprotein particle remodeling (GO:0034369)4.64520595
49protein-lipid complex remodeling (GO:0034368)4.64520595
50macromolecular complex remodeling (GO:0034367)4.64520595
51triglyceride homeostasis (GO:0070328)4.54519627
52acylglycerol homeostasis (GO:0055090)4.54519627
53cellular ketone body metabolic process (GO:0046950)4.52048820
54response to mercury ion (GO:0046689)4.51957887
55negative regulation of cholesterol transport (GO:0032375)4.50817941
56negative regulation of sterol transport (GO:0032372)4.50817941
57* amino-acid betaine metabolic process (GO:0006577)4.48101181
58indolalkylamine metabolic process (GO:0006586)4.47986746
59alkaloid metabolic process (GO:0009820)4.47614906
60bile acid and bile salt transport (GO:0015721)4.44698752
61phospholipid efflux (GO:0033700)4.43959061
62amine catabolic process (GO:0009310)4.40311754
63cellular biogenic amine catabolic process (GO:0042402)4.40311754
64coenzyme catabolic process (GO:0009109)4.37918248
65imidazole-containing compound metabolic process (GO:0052803)4.37333300
66cellular glucuronidation (GO:0052695)4.35955234
67* cellular amino acid catabolic process (GO:0009063)4.34813288
68negative regulation of blood coagulation (GO:0030195)4.34369745
69negative regulation of hemostasis (GO:1900047)4.34369745
70glutamate metabolic process (GO:0006536)4.30044487
71* glycine metabolic process (GO:0006544)4.27770248
72plasma lipoprotein particle clearance (GO:0034381)4.24905449
73* serine family amino acid metabolic process (GO:0009069)4.21157538
74serine family amino acid biosynthetic process (GO:0009070)4.18196393
75benzene-containing compound metabolic process (GO:0042537)4.17962220
76flavonoid metabolic process (GO:0009812)4.17872341
77cellular modified amino acid catabolic process (GO:0042219)4.17753634
78ethanol oxidation (GO:0006069)4.11935611
79arginine metabolic process (GO:0006525)4.09897657
80negative regulation of protein activation cascade (GO:2000258)4.09618781
81cholesterol efflux (GO:0033344)4.08486313
82regulation of humoral immune response (GO:0002920)4.08457533
83aldehyde catabolic process (GO:0046185)4.07539277
84drug catabolic process (GO:0042737)4.05086206
85dicarboxylic acid biosynthetic process (GO:0043650)4.02146526
86fibrinolysis (GO:0042730)3.97675072
87intestinal cholesterol absorption (GO:0030299)3.97472487
88negative regulation of coagulation (GO:0050819)3.97250618
89low-density lipoprotein particle remodeling (GO:0034374)3.96511609
90killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.95240950
91disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.95240950
92sodium-independent organic anion transport (GO:0043252)3.92755260
93ketone body metabolic process (GO:1902224)3.91210713
94uronic acid metabolic process (GO:0006063)3.91064826
95glucuronate metabolic process (GO:0019585)3.91064826
96acute-phase response (GO:0006953)3.89492464
97negative regulation of wound healing (GO:0061045)3.87498169
98plasma lipoprotein particle assembly (GO:0034377)3.86917520
99blood coagulation, intrinsic pathway (GO:0007597)3.82977895
100* organic acid catabolic process (GO:0016054)3.81059077
101* carboxylic acid catabolic process (GO:0046395)3.81059077
102opsonization (GO:0008228)3.79064741
103aminoglycoside antibiotic metabolic process (GO:0030647)3.79040545
104short-chain fatty acid metabolic process (GO:0046459)3.78240761
105amino acid salvage (GO:0043102)3.77890622
106L-methionine salvage (GO:0071267)3.77890622
107L-methionine biosynthetic process (GO:0071265)3.77890622
108cofactor catabolic process (GO:0051187)3.76869876
109regulation of bile acid biosynthetic process (GO:0070857)3.76562696
110acetyl-CoA metabolic process (GO:0006084)3.74560219
111complement activation, classical pathway (GO:0006958)3.70079876
112cholesterol homeostasis (GO:0042632)3.69972139
113positive regulation of lipoprotein lipase activity (GO:0051006)3.69207431
114positive regulation of triglyceride lipase activity (GO:0061365)3.69207431
115polyketide metabolic process (GO:0030638)3.68666038
116doxorubicin metabolic process (GO:0044598)3.68666038
117daunorubicin metabolic process (GO:0044597)3.68666038
118very-low-density lipoprotein particle assembly (GO:0034379)3.68069332
119phospholipid homeostasis (GO:0055091)3.67583533
120negative regulation of lipase activity (GO:0060192)3.67015233
121complement activation (GO:0006956)3.66857858
122protein activation cascade (GO:0072376)3.66101326
123positive regulation of lipid catabolic process (GO:0050996)3.65855400
124xenobiotic metabolic process (GO:0006805)3.65449440
125urate metabolic process (GO:0046415)3.65329224
126sterol homeostasis (GO:0055092)3.64288909
127cytolysis (GO:0019835)3.63423604
128fat-soluble vitamin biosynthetic process (GO:0042362)3.62902744
129positive regulation of hemostasis (GO:1900048)3.62125938
130positive regulation of blood coagulation (GO:0030194)3.62125938
131heme transport (GO:0015886)3.62036261
132NAD biosynthetic process (GO:0009435)3.60659204
133regulation of cholesterol homeostasis (GO:2000188)3.60431894
134nicotinamide nucleotide biosynthetic process (GO:0019359)3.57466177
135pyridine nucleotide biosynthetic process (GO:0019363)3.57466177
136positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.54903486
137hormone catabolic process (GO:0042447)3.51213944
138exogenous drug catabolic process (GO:0042738)10.0642270

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse8.46253191
2PPARA_22158963_ChIP-Seq_LIVER_Mouse7.24491561
3EGR1_23403033_ChIP-Seq_LIVER_Mouse7.12737370
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.51350087
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.29761287
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.16129385
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.80780918
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.05916777
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.99932623
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.47449094
11HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.06008059
12* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.02998578
13ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.9944998
14TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.95030165
15IGF1R_20145208_ChIP-Seq_DFB_Human1.77554472
16GBX2_23144817_ChIP-Seq_PC3_Human1.61897254
17HTT_18923047_ChIP-ChIP_STHdh_Human1.57494223
18POU3F2_20337985_ChIP-ChIP_501MEL_Human1.53414365
19* FOXA2_19822575_ChIP-Seq_HepG2_Human1.53401375
20VDR_22108803_ChIP-Seq_LS180_Human1.52276583
21CLOCK_20551151_ChIP-Seq_293T_Human1.45061538
22ER_23166858_ChIP-Seq_MCF-7_Human1.41546830
23* HNF4A_19822575_ChIP-Seq_HepG2_Human1.40521566
24NFE2_27457419_Chip-Seq_LIVER_Mouse1.39552152
25PIAS1_25552417_ChIP-Seq_VCAP_Human1.38728167
26GATA1_22025678_ChIP-Seq_K562_Human1.34572795
27ESR1_20079471_ChIP-ChIP_T-47D_Human1.31108935
28STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.27442631
29GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26457584
30SUZ12_27294783_Chip-Seq_NPCs_Mouse1.24188136
31EZH2_27294783_Chip-Seq_NPCs_Mouse1.23575759
32FLI1_27457419_Chip-Seq_LIVER_Mouse1.22365752
33PCGF2_27294783_Chip-Seq_NPCs_Mouse1.20667970
34RXRA_24833708_ChIP-Seq_LIVER_Mouse1.20484408
35ZNF274_21170338_ChIP-Seq_K562_Hela1.19136673
36PHF8_20622853_ChIP-Seq_HELA_Human1.16436719
37AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.14628865
38CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.14169101
39HNFA_21074721_ChIP-Seq_CACO-2_Human1.13852078
40CTBP1_25329375_ChIP-Seq_LNCAP_Human1.13512621
41THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.13382950
42ETV2_25802403_ChIP-Seq_MESCs_Mouse1.11729080
43NANOG_19829295_ChIP-Seq_ESCs_Human1.08626330
44SOX2_19829295_ChIP-Seq_ESCs_Human1.08626330
45IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.07951059
46CBP_20019798_ChIP-Seq_JUKART_Human1.06450150
47IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.06450150
48GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.06204755
49PCGF2_27294783_Chip-Seq_ESCs_Mouse1.05584537
50ZFP57_27257070_Chip-Seq_ESCs_Mouse1.03887880
51CDX2_22108803_ChIP-Seq_LS180_Human1.03138512
52TCF4_22108803_ChIP-Seq_LS180_Human1.02462995
53UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.02384901
54KLF5_20875108_ChIP-Seq_MESCs_Mouse1.00760157
55NFYA_21822215_ChIP-Seq_K562_Human1.00696701
56ESR1_15608294_ChIP-ChIP_MCF-7_Human0.99506426
57STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.99430385
58ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.98303191
59FOXA1_25329375_ChIP-Seq_VCAP_Human0.97094788
60FOXA1_27270436_Chip-Seq_PROSTATE_Human0.97094788
61TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.96833574
62TP53_18474530_ChIP-ChIP_U2OS_Human0.96223731
63TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95872420
64GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.95832793
65ETV1_20927104_ChIP-Seq_GIST48_Human0.95557649
66* STAT3_23295773_ChIP-Seq_U87_Human0.95441623
67GATA6_21074721_ChIP-Seq_CACO-2_Human0.94436745
68NCOR_22424771_ChIP-Seq_293T_Human0.94261097
69CTBP2_25329375_ChIP-Seq_LNCAP_Human0.93560571
70KAP1_22055183_ChIP-Seq_ESCs_Mouse0.89696285
71SOX2_27498859_Chip-Seq_STOMACH_Mouse0.89446742
72NFYB_21822215_ChIP-Seq_K562_Human0.88865865
73P300_19829295_ChIP-Seq_ESCs_Human0.88413420
74E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.87569726
75EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.87555634
76AUTS2_25519132_ChIP-Seq_293T-REX_Human0.87473745
77FOXA1_21572438_ChIP-Seq_LNCaP_Human0.86841131
78OCT4_18555785_Chip-Seq_ESCs_Mouse0.86800301
79CBX2_22325352_ChIP-Seq_293T-Rex_Human0.86762395
80PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.86139668
81IRF8_22096565_ChIP-ChIP_GC-B_Human0.85094837
82FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.85052050
83TCF4_23295773_ChIP-Seq_U87_Human0.84617335
84OCT4_21477851_ChIP-Seq_ESCs_Mouse0.84445631
85PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.84435271
86SMAD4_21741376_ChIP-Seq_EPCs_Human0.83723572
87PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.83675336
88STAT3_18555785_Chip-Seq_ESCs_Mouse0.83666599
89EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.83062403
90RBPJ_21746931_ChIP-Seq_IB4_Human0.82743709
91GATA4_25053715_ChIP-Seq_YYC3_Human0.81889638
92AR_25329375_ChIP-Seq_VCAP_Human0.81877776
93SMAD4_21799915_ChIP-Seq_A2780_Human0.81338141
94MYC_19829295_ChIP-Seq_ESCs_Human0.81240152
95ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.80545268
96SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.80339900
97GATA3_21878914_ChIP-Seq_MCF-7_Human0.80182645
98RARG_19884340_ChIP-ChIP_MEFs_Mouse0.77114252
99SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.75804618
100RARA_24833708_ChIP-Seq_LIVER_Mouse0.73551428
101Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.72042466
102ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.71622002
103BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.69584699
104CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.68398700
105SALL4_18804426_ChIP-ChIP_XEN_Mouse0.67723651
106BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.65980899
107RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.65784158
108ZNF263_19887448_ChIP-Seq_K562_Human0.65601178
109ESR2_21235772_ChIP-Seq_MCF-7_Human0.65370806
110AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.64937940
111RAD21_21589869_ChIP-Seq_MESCs_Mouse0.63880350
112NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.63639367
113RARB_24833708_ChIP-Seq_LIVER_Mouse0.62819752
114NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.61463956
115NRF2_20460467_ChIP-Seq_MEFs_Mouse0.61463956
116CEBPB_22108803_ChIP-Seq_LS180_Human0.59224136
117NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.57851693
118EGR1_19032775_ChIP-ChIP_M12_Human0.56368351
119AR_20517297_ChIP-Seq_VCAP_Human0.55593127
120STAT3_1855785_ChIP-Seq_MESCs_Mouse0.54778717
121STAT1_17558387_ChIP-Seq_HELA_Human0.53744200
122PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.53095534
123TAF15_26573619_Chip-Seq_HEK293_Human0.52380620
124MYC_19915707_ChIP-ChIP_AK7_Human0.51852066
125ESET_19884257_ChIP-Seq_ESCs_Mouse0.51544384
126FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.51214943
127FOXA1_25552417_ChIP-Seq_VCAP_Human0.50868070
128NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.50363856
129CDX2_20551321_ChIP-Seq_CACO-2_Human0.50014247
130FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.49710588
131ESR1_21235772_ChIP-Seq_MCF-7_Human0.47881405
132CBP_21632823_ChIP-Seq_H3396_Human0.47705106
133PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.46971756
134LXR_22292898_ChIP-Seq_THP-1_Human0.46863134
135IRF1_19129219_ChIP-ChIP_H3396_Human0.46599624
136PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.45081419
137* P53_21459846_ChIP-Seq_SAOS-2_Human0.45025607
138PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.44780343
139CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.44674211
140TAF2_19829295_ChIP-Seq_ESCs_Human0.44349949
141SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.40865293
142FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.40452902
143GATA1_19941827_ChIP-Seq_MEL_Mouse0.39581324
144STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.39396377
145PPAR_26484153_Chip-Seq_NCI-H1993_Human0.39212397
146SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.38947017
147GATA6_25053715_ChIP-Seq_YYC3_Human0.37284082
148GATA2_19941826_ChIP-Seq_K562_Human0.37256983
149BCAT_22108803_ChIP-Seq_LS180_Human0.36946081
150GATA1_19941826_ChIP-Seq_K562_Human0.36928267
151ERG_20517297_ChIP-Seq_VCAP_Human0.36621624
152EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.36358389
153FOXH1_21741376_ChIP-Seq_EPCs_Human0.35923387
154CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.35369641
155MYC_27129775_Chip-Seq_CORNEA_Mouse0.35212479
156FOXO3_23340844_ChIP-Seq_DLD1_Human0.35204744
157ERG_21242973_ChIP-ChIP_JURKAT_Human0.35040743
158SPI1_26923725_Chip-Seq_HPCs_Mouse0.34290768
159SOX3_22085726_ChIP-Seq_MUSCLE_Mouse0.34138315
160LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.34019134
161CRX_20693478_ChIP-Seq_RETINA_Mouse0.33987113

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.30480627
2MP0005360_urolithiasis7.67351311
3MP0005085_abnormal_gallbladder_physiolo6.43010229
4MP0005365_abnormal_bile_salt6.14370961
5MP0008875_abnormal_xenobiotic_pharmacok5.15366257
6MP0003806_abnormal_nucleotide_metabolis4.26472721
7MP0003252_abnormal_bile_duct3.89970911
8MP0010329_abnormal_lipoprotein_level3.51623223
9MP0009840_abnormal_foam_cell3.19974323
10MP0005083_abnormal_biliary_tract2.97996921
11MP0003195_calcinosis2.92446016
12MP0005332_abnormal_amino_acid2.92035346
13MP0001666_abnormal_nutrient_absorption2.55821396
14MP0004019_abnormal_vitamin_homeostasis2.29530625
15MP0003191_abnormal_cellular_cholesterol2.20374234
16MP0000609_abnormal_liver_physiology2.13699024
17MP0002118_abnormal_lipid_homeostasis2.07604692
18MP0002138_abnormal_hepatobiliary_system2.05556791
19MP0003868_abnormal_feces_composition1.95018054
20MP0005319_abnormal_enzyme/_coenzyme1.84824925
21MP0001764_abnormal_homeostasis1.73527004
22MP0005584_abnormal_enzyme/coenzyme_acti1.58536835
23MP0009697_abnormal_copulation1.57271946
24MP0005451_abnormal_body_composition1.57053402
25MP0003011_delayed_dark_adaptation1.38469252
26MP0009643_abnormal_urine_homeostasis1.33933432
27MP0003186_abnormal_redox_activity1.33444306
28MP0003656_abnormal_erythrocyte_physiolo1.22288969
29MP0000598_abnormal_liver_morphology1.16907945
30MP0005647_abnormal_sex_gland1.13883843
31MP0009764_decreased_sensitivity_to1.08174516
32MP0005636_abnormal_mineral_homeostasis1.02771834
33MP0009763_increased_sensitivity_to1.00085913
34MP0000604_amyloidosis0.99846514
35MP0003705_abnormal_hypodermis_morpholog0.98621352
36MP0002254_reproductive_system_inflammat0.96349949
37MP0008469_abnormal_protein_level0.91072937
38MP0005408_hypopigmentation0.89315672
39MP0009642_abnormal_blood_homeostasis0.88297223
40MP0006036_abnormal_mitochondrial_physio0.87524047
41MP0010368_abnormal_lymphatic_system0.87159668
42MP0002876_abnormal_thyroid_physiology0.86482887
43MP0005084_abnormal_gallbladder_morpholo0.86245004
44MP0005670_abnormal_white_adipose0.79322026
45MP0005376_homeostasis/metabolism_phenot0.79263344
46MP0009765_abnormal_xenobiotic_induced0.77968104
47MP0001661_extended_life_span0.76128674
48MP0002078_abnormal_glucose_homeostasis0.75612811
49MP0005551_abnormal_eye_electrophysiolog0.72811084
50MP0003879_abnormal_hair_cell0.72080261
51MP0002971_abnormal_brown_adipose0.70901390
52MP0005220_abnormal_exocrine_pancreas0.70215848
53MP0001756_abnormal_urination0.69067714
54MP0005535_abnormal_body_temperature0.68839846
55MP0005334_abnormal_fat_pad0.66899356
56MP0009053_abnormal_anal_canal0.62993851
57MP0005266_abnormal_metabolism0.62429870
58MP0006035_abnormal_mitochondrial_morpho0.61564902
59MP0003690_abnormal_glial_cell0.61364271
60MP0004130_abnormal_muscle_cell0.61046078
61MP0003718_maternal_effect0.58738055
62MP0005187_abnormal_penis_morphology0.58544052
63MP0000639_abnormal_adrenal_gland0.56512892
64MP0003329_amyloid_beta_deposits0.55747859
65MP0003646_muscle_fatigue0.55719215
66MP0004381_abnormal_hair_follicle0.55682009
67MP0002282_abnormal_trachea_morphology0.55351360
68MP0001986_abnormal_taste_sensitivity0.54828693
69MP0005395_other_phenotype0.54112973
70MP0002136_abnormal_kidney_physiology0.53963124
71MP0004142_abnormal_muscle_tone0.51950848
72MP0005464_abnormal_platelet_physiology0.50906385
73MP0005448_abnormal_energy_balance0.50486110
74MP0003724_increased_susceptibility_to0.48502746
75MP0003638_abnormal_response/metabolism_0.48242611
76MP0002928_abnormal_bile_duct0.46973128
77MP0004782_abnormal_surfactant_physiolog0.44434592
78MP0009785_altered_susceptibility_to0.44365434
79MP0008874_decreased_physiological_sensi0.44090727
80MP0008873_increased_physiological_sensi0.43508099
81MP0002822_catalepsy0.43437537
82MP0003436_decreased_susceptibility_to0.42726649
83MP0010386_abnormal_urinary_bladder0.41679798
84MP0003953_abnormal_hormone_level0.40570584
85MP0003959_abnormal_lean_body0.40408300
86MP0001944_abnormal_pancreas_morphology0.39424837
87MP0005377_hearing/vestibular/ear_phenot0.38367682
88MP0003878_abnormal_ear_physiology0.38367682
89MP0001984_abnormal_olfaction0.38182656
90MP0002234_abnormal_pharynx_morphology0.37576283
91MP0005248_abnormal_Harderian_gland0.37316058
92MP0009672_abnormal_birth_weight0.36062277
93MP0008872_abnormal_physiological_respon0.36041974
94MP0002909_abnormal_adrenal_gland0.35985792
95MP0000579_abnormal_nail_morphology0.35861733
96MP0003075_altered_response_to0.35547201
97MP0008961_abnormal_basal_metabolism0.35449326
98MP0005666_abnormal_adipose_tissue0.35120037
99MP0005166_decreased_susceptibility_to0.34982453
100MP0000230_abnormal_systemic_arterial0.34685788
101MP0002796_impaired_skin_barrier0.34100480
102MP0006082_CNS_inflammation0.33788106
103MP0005379_endocrine/exocrine_gland_phen0.33261747
104MP0005646_abnormal_pituitary_gland0.32774126
105MP0002168_other_aberrant_phenotype0.32669193
106MP0001853_heart_inflammation0.31534677
107MP0009115_abnormal_fat_cell0.31076217
108MP0004043_abnormal_pH_regulation0.30285334
109MP0002837_dystrophic_cardiac_calcinosis0.29671764
110MP0001845_abnormal_inflammatory_respons0.29155448
111MP0009384_cardiac_valve_regurgitation0.29087067
112MP0002135_abnormal_kidney_morphology0.29053798
113MP0000249_abnormal_blood_vessel0.28864056
114MP0002638_abnormal_pupillary_reflex0.28362325
115MP0008775_abnormal_heart_ventricle0.28036519
116MP0002970_abnormal_white_adipose0.27684312
117MP0005058_abnormal_lysosome_morphology0.27292824
118MP0001243_abnormal_dermal_layer0.26797204
119MP0001915_intracranial_hemorrhage0.26533452
120MP0004883_abnormal_blood_vessel0.26087792
121MP0001765_abnormal_ion_homeostasis0.26066668
122MP0002069_abnormal_eating/drinking_beha0.25619458
123MP0002132_abnormal_respiratory_system0.25598792
124MP0001881_abnormal_mammary_gland0.25046519
125MP0005645_abnormal_hypothalamus_physiol0.23898343

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.42534158
2Intrahepatic cholestasis (HP:0001406)7.24602010
3Deep venous thrombosis (HP:0002625)7.22955307
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.69426471
5Prolonged partial thromboplastin time (HP:0003645)6.50312762
6Hypobetalipoproteinemia (HP:0003563)6.29405787
7Xanthomatosis (HP:0000991)6.19450551
8Hyperlipoproteinemia (HP:0010980)5.47708093
9Complement deficiency (HP:0004431)5.23388284
10Joint hemorrhage (HP:0005261)4.78154650
11Hyperglycinemia (HP:0002154)4.75260143
12Hyperammonemia (HP:0001987)4.66822033
13Hypolipoproteinemia (HP:0010981)4.65861218
14Epidermoid cyst (HP:0200040)4.42170417
15Abnormality of sulfur amino acid metabolism (HP:0004339)4.34627510
16Abnormality of glutamine family amino acid metabolism (HP:0010902)4.33379453
17Abnormality of methionine metabolism (HP:0010901)4.33275216
18Abnormality of the common coagulation pathway (HP:0010990)4.33138807
19Ketosis (HP:0001946)4.28394020
20Hyperglycinuria (HP:0003108)4.27877519
21Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.27316363
22Abnormality of aspartate family amino acid metabolism (HP:0010899)4.27283990
23Abnormality of glycine metabolism (HP:0010895)4.19018144
24Abnormality of serine family amino acid metabolism (HP:0010894)4.19018144
25Fat malabsorption (HP:0002630)4.09801502
26Hypoalphalipoproteinemia (HP:0003233)4.02244904
27Abnormality of pyrimidine metabolism (HP:0004353)3.93577268
28Abnormality of complement system (HP:0005339)3.80636858
29Hypoglycemic coma (HP:0001325)3.79097266
30Conjugated hyperbilirubinemia (HP:0002908)3.71039408
31Abnormality of the intrinsic pathway (HP:0010989)3.64521273
32Hypercholesterolemia (HP:0003124)3.52234310
33Abnormality of fatty-acid metabolism (HP:0004359)3.42604279
34Nephritis (HP:0000123)3.39485603
35Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.33741993
36Hyperbilirubinemia (HP:0002904)3.32129412
37Abnormality of serum amino acid levels (HP:0003112)3.28498803
38Delayed CNS myelination (HP:0002188)3.22093643
39Abnormality of nucleobase metabolism (HP:0010932)3.19254144
40Fair hair (HP:0002286)3.12539658
41Steatorrhea (HP:0002570)3.09626106
42Ketoacidosis (HP:0001993)3.05272591
43Hepatocellular carcinoma (HP:0001402)2.94268361
44Spontaneous abortion (HP:0005268)2.92878072
45Hypochromic microcytic anemia (HP:0004840)2.86165832
46Metabolic acidosis (HP:0001942)2.83610477
47Myocardial infarction (HP:0001658)2.82592677
48Abnormality of purine metabolism (HP:0004352)2.82092582
49Hyperphosphaturia (HP:0003109)2.80615694
50Lethargy (HP:0001254)2.76091923
51Gout (HP:0001997)2.71864422
52Abnormality of dicarboxylic acid metabolism (HP:0010995)2.69758254
53Dicarboxylic aciduria (HP:0003215)2.69758254
54Skin nodule (HP:0200036)2.67801637
55Vascular calcification (HP:0004934)2.65728594
56Systemic lupus erythematosus (HP:0002725)2.64419357
57Osteomalacia (HP:0002749)2.63105834
58Cerebral edema (HP:0002181)2.51433405
59Acanthocytosis (HP:0001927)2.47910205
60Glomerulonephritis (HP:0000099)2.47635588
61Irritability (HP:0000737)2.46193215
62Spastic diplegia (HP:0001264)2.44534759
63Neonatal onset (HP:0003623)2.42379880
64Hypokalemic alkalosis (HP:0001949)2.39405509
65Increased circulating renin level (HP:0000848)2.38405930
66Hypoglycemic seizures (HP:0002173)2.37497282
67Metabolic alkalosis (HP:0200114)2.36464291
68Malnutrition (HP:0004395)2.34741011
69Cardiovascular calcification (HP:0011915)2.33956263
70Abnormal gallbladder morphology (HP:0012437)2.33658311
71Mitral stenosis (HP:0001718)2.31094772
72Recurrent gram-negative bacterial infections (HP:0005420)2.28734349
73Cholelithiasis (HP:0001081)2.27283535
74Abnormality of vitamin metabolism (HP:0100508)2.26593305
75Generalized hypopigmentation of hair (HP:0011358)2.22678318
76Generalized aminoaciduria (HP:0002909)2.22448759
77Abnormal gallbladder physiology (HP:0012438)2.21266869
78Cholecystitis (HP:0001082)2.21266869
79Abnormal biliary tract physiology (HP:0012439)2.19853784
80Bile duct proliferation (HP:0001408)2.19853784
81Abnormal urine phosphate concentration (HP:0012599)2.17629215
82Amyloidosis (HP:0011034)2.16968081
83Pancreatitis (HP:0001733)2.16304446
84Menorrhagia (HP:0000132)2.15495435
85Late onset (HP:0003584)2.15435523
86Vomiting (HP:0002013)2.15328943
87Esophageal varix (HP:0002040)2.13634498
88Enlarged kidneys (HP:0000105)2.13548379
89Gingival bleeding (HP:0000225)2.12300286
90Sensorimotor neuropathy (HP:0007141)2.11817228
91Brushfield spots (HP:0001088)2.11300848
92Alkalosis (HP:0001948)2.10923856
93Reduced antithrombin III activity (HP:0001976)2.08365655
94Arthropathy (HP:0003040)2.05694774
95Rickets (HP:0002748)2.03223684
96Opisthotonus (HP:0002179)2.02955497
97Thrombophlebitis (HP:0004418)2.02928654
98Pulmonary embolism (HP:0002204)2.02801063
99Abnormal urine output (HP:0012590)2.02313428
100Potter facies (HP:0002009)2.00337031
101Facial shape deformation (HP:0011334)2.00337031
102Neonatal hypoglycemia (HP:0001998)1.99605008
103Poikilocytosis (HP:0004447)1.94273391
104Abnormality of the gallbladder (HP:0005264)1.92039778
105Joint swelling (HP:0001386)1.91680912
106Proximal tubulopathy (HP:0000114)1.91538370
107Hyperinsulinemic hypoglycemia (HP:0000825)1.90945691
108Hemorrhage of the eye (HP:0011885)1.90636992
109Hypophosphatemic rickets (HP:0004912)1.90424034
110Renal cortical cysts (HP:0000803)1.90379671
111Hydroxyprolinuria (HP:0003080)1.90228680
112Abnormality of proline metabolism (HP:0010907)1.90228680
113Purpura (HP:0000979)1.87823093
114Abnormal enzyme/coenzyme activity (HP:0012379)1.87697416
115Abnormal cartilage morphology (HP:0002763)1.86847355
116Increased purine levels (HP:0004368)1.86263471
117Hyperuricemia (HP:0002149)1.86263471
118Glycosuria (HP:0003076)1.84690348
119Abnormality of urine glucose concentration (HP:0011016)1.84690348
120Abnormality of iron homeostasis (HP:0011031)1.83996142
121Abnormality of transition element cation homeostasis (HP:0011030)1.83383216
122Polyuria (HP:0000103)1.82722367
123Hypokalemia (HP:0002900)1.77548498
124Hypomagnesemia (HP:0002917)1.75991294
125Abnormality of renal excretion (HP:0011036)1.75006249
126Hypothermia (HP:0002045)1.71046769
127Hyperactive renin-angiotensin system (HP:0000841)1.68805073
128Gangrene (HP:0100758)1.66140019
129Cerebral palsy (HP:0100021)1.65786084

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.52474885
2FGFR44.61005620
3SIK14.38414449
4ERN14.16657100
5OXSR13.81154546
6TAOK33.14663161
7INSRR2.99421076
8ERBB42.91659853
9WNK42.88816486
10MAP4K22.43802017
11PIK3CA2.41369881
12ADRBK22.28065966
13MAP2K42.27324894
14MST1R2.24163811
15TXK2.16962100
16PKN22.01357541
17MAPK111.92932083
18ZAK1.87366670
19PIK3CG1.86559675
20FLT31.85856390
21TYK21.66818558
22BCR1.63051697
23ABL21.61299071
24PINK11.52448709
25LATS11.52217975
26DAPK21.47240059
27MUSK1.43874606
28NEK91.41682748
29TRIB31.38351950
30STK391.37002478
31KDR1.34373649
32FRK1.31806442
33CAMKK21.31766740
34BMPR1B1.31113113
35NTRK31.25542166
36PTK61.23774487
37JAK21.22308009
38FGFR21.19523647
39GRK61.18803302
40STK38L1.17085454
41MAP3K121.16357471
42TLK11.16115509
43PRKAA21.16024927
44MAP3K71.15088422
45PAK31.14095653
46IRAK31.11693112
47MYLK1.08600426
48MAP3K141.06759510
49FER1.06756366
50MAPK41.05398613
51MAPKAPK31.04109430
52TBK11.04071862
53MAP2K31.03724407
54MAPK151.00390344
55ERBB20.96680075
56CASK0.95897170
57JAK10.93069650
58PRKCZ0.89941409
59STK160.89593012
60PRKACA0.89190103
61OBSCN0.88837403
62TRIM280.86898145
63MAP3K30.85959494
64MAPK120.83715210
65TIE10.82722248
66CDK60.80569682
67PRKCE0.79440793
68MAP3K100.78460777
69MAP3K110.76931376
70MET0.76484208
71NUAK10.76406727
72PRKACG0.75144408
73MAP3K40.73781623
74GSK3A0.73290205
75CAMK2G0.72595822
76MAP2K60.72281302
77DYRK1B0.72064702
78EPHB10.71937165
79CSK0.71391234
80PRKG10.70456610
81PRKAA10.68879565
82EPHA30.66604628
83SGK30.65039374
84TGFBR20.63965268
85CSNK1G10.63893186
86ACVR1B0.63801474
87IKBKE0.63004660
88ADRBK10.62992887
89MAPK70.62665271
90MAPK130.62556373
91PHKG20.62466371
92PHKG10.62466371
93SGK20.55978918
94GRK10.55415119
95CSNK1A10.55286219
96IRAK20.54072279
97CSNK1D0.53585691
98CSF1R0.51189895
99PDPK10.49709148
100STK380.49444857
101CDK40.48757538
102PRKCQ0.47848869
103IRAK10.47763179
104TNK20.46711559
105CAMK1D0.46295684
106TAOK20.45370889
107FGFR30.43886630
108SGK4940.43618150
109SGK2230.43618150
110EPHA40.43462464
111PBK0.43283915
112PTK20.42786911
113IGF1R0.41925362
114CAMKK10.41139918
115AKT30.40339585
116MAP3K50.39921762
117PRKCG0.39378246
118MAP3K130.39102559
119IKBKB0.38645722
120RPS6KA30.37851221
121GRK70.37761179
122PRKCB0.37729647
123PDK40.36680420
124PDK30.36680420
125MAP2K70.36266402
126STK30.34868354
127BRSK20.34121940
128ERBB30.33964440
129CAMK10.33551025
130MAP3K60.32022111
131MAP2K10.31462806
132SGK10.31088202
133EIF2AK30.30628981
134PKN10.30527070
135PRKACB0.30521233
136WNK30.30107886
137RIPK10.30048735
138PDK10.29758473
139CSNK1G30.29218899
140NLK0.28413460
141CSNK1G20.28002610
142EGFR0.26600900
143PRKCA0.26200430
144MAP2K20.25581032
145CAMK40.23897904
146MTOR0.23870521
147ABL10.23533400
148RET0.21191720
149MAP3K10.21073970

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.47986149
2Nitrogen metabolism_Homo sapiens_hsa009103.54802984
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.40484195
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.34039632
5Arginine biosynthesis_Homo sapiens_hsa002203.05635217
6Tryptophan metabolism_Homo sapiens_hsa003802.69303164
7Complement and coagulation cascades_Homo sapiens_hsa046102.68434591
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.68343677
9Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.65223485
10* Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.50298189
11Fatty acid degradation_Homo sapiens_hsa000712.47287918
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.42735407
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.34815637
14Butanoate metabolism_Homo sapiens_hsa006502.20228446
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.14106714
16Peroxisome_Homo sapiens_hsa041462.10560668
17Propanoate metabolism_Homo sapiens_hsa006401.96593850
18Steroid hormone biosynthesis_Homo sapiens_hsa001401.95587281
19Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.94354090
20Chemical carcinogenesis_Homo sapiens_hsa052041.94325829
21Histidine metabolism_Homo sapiens_hsa003401.91875224
22PPAR signaling pathway_Homo sapiens_hsa033201.82364879
23Drug metabolism - other enzymes_Homo sapiens_hsa009831.79624794
24Fatty acid metabolism_Homo sapiens_hsa012121.77023820
25beta-Alanine metabolism_Homo sapiens_hsa004101.75577194
26Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.74062107
27Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.73828495
28Retinol metabolism_Homo sapiens_hsa008301.72845295
29Staphylococcus aureus infection_Homo sapiens_hsa051501.70319370
30Caffeine metabolism_Homo sapiens_hsa002321.70244267
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.66634018
32Selenocompound metabolism_Homo sapiens_hsa004501.58035315
33Phenylalanine metabolism_Homo sapiens_hsa003601.54902017
342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.51586846
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.50644703
36Bile secretion_Homo sapiens_hsa049761.47406478
37Tyrosine metabolism_Homo sapiens_hsa003501.42064526
38Pyruvate metabolism_Homo sapiens_hsa006201.36230571
39Sulfur metabolism_Homo sapiens_hsa009201.36108677
40Cysteine and methionine metabolism_Homo sapiens_hsa002701.35512064
41Fatty acid elongation_Homo sapiens_hsa000621.32393441
42Folate biosynthesis_Homo sapiens_hsa007901.27955108
43Starch and sucrose metabolism_Homo sapiens_hsa005001.27645961
44Biosynthesis of amino acids_Homo sapiens_hsa012301.20854119
45Steroid biosynthesis_Homo sapiens_hsa001001.17301461
46ABC transporters_Homo sapiens_hsa020101.16880492
47Carbon metabolism_Homo sapiens_hsa012001.13391203
48Fat digestion and absorption_Homo sapiens_hsa049751.09816310
49Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.08232378
50Cyanoamino acid metabolism_Homo sapiens_hsa004601.07942883
51Vitamin B6 metabolism_Homo sapiens_hsa007501.02393479
52Maturity onset diabetes of the young_Homo sapiens_hsa049501.00314149
53Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.99693396
54Arginine and proline metabolism_Homo sapiens_hsa003300.99387138
55Sulfur relay system_Homo sapiens_hsa041220.96433967
56Vitamin digestion and absorption_Homo sapiens_hsa049770.92885534
57Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.88985856
58Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.86898127
59Lysine degradation_Homo sapiens_hsa003100.80416933
60One carbon pool by folate_Homo sapiens_hsa006700.78618829
61Glutathione metabolism_Homo sapiens_hsa004800.69406156
62Glycerolipid metabolism_Homo sapiens_hsa005610.68287118
63Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.68206725
64Pentose phosphate pathway_Homo sapiens_hsa000300.59967407
65* Metabolic pathways_Homo sapiens_hsa011000.48480541
66Fatty acid biosynthesis_Homo sapiens_hsa000610.46703855
67Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.46268338
68Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.33901190
69Prion diseases_Homo sapiens_hsa050200.33084554
70Fructose and mannose metabolism_Homo sapiens_hsa000510.25825061
71alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.25305872
72Galactose metabolism_Homo sapiens_hsa000520.23472957
73Linoleic acid metabolism_Homo sapiens_hsa005910.22341567
74Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.21658011
75Adipocytokine signaling pathway_Homo sapiens_hsa049200.18675439
76Insulin resistance_Homo sapiens_hsa049310.18653545
77Glycerophospholipid metabolism_Homo sapiens_hsa005640.17735473
78Pertussis_Homo sapiens_hsa051330.14702908
79Serotonergic synapse_Homo sapiens_hsa047260.11082902
80Glucagon signaling pathway_Homo sapiens_hsa049220.05670747
81Phototransduction_Homo sapiens_hsa047440.01187016
82Pyrimidine metabolism_Homo sapiens_hsa00240-0.2571051
83Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.2563240
84RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622-0.2467866
85Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.2404360
86Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.2342032
87Ether lipid metabolism_Homo sapiens_hsa00565-0.2244691
88Thyroid hormone synthesis_Homo sapiens_hsa04918-0.2139634
89Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1995218
90Parkinsons disease_Homo sapiens_hsa05012-0.1859004
91Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1850335
92Vascular smooth muscle contraction_Homo sapiens_hsa04270-0.1831682
93Hepatitis C_Homo sapiens_hsa05160-0.1827233
94Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601-0.1784897
95Renin-angiotensin system_Homo sapiens_hsa04614-0.1768224
96Sphingolipid metabolism_Homo sapiens_hsa00600-0.1731441
97African trypanosomiasis_Homo sapiens_hsa05143-0.1674117
98Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1558407
99Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1491727
100Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1490295
101Insulin signaling pathway_Homo sapiens_hsa04910-0.1367446
102Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603-0.1174878
103Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1120041
104Oxidative phosphorylation_Homo sapiens_hsa00190-0.0908670
105Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080-0.0880654
106Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0879649
107Regulation of autophagy_Homo sapiens_hsa04140-0.0610337
108Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0377525
109Mineral absorption_Homo sapiens_hsa04978-0.0260211
110Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0219004
111Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563-0.0171918
112Circadian rhythm_Homo sapiens_hsa04710-0.0132486
113AMPK signaling pathway_Homo sapiens_hsa04152-0.0064728

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