DMKN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is upregulated in inflammatory diseases, and it was first observed as expressed in the differentiated layers of skin. The most interesting aspect of this gene is the differential use of promoters and terminators to generate isoforms with unique cellular distributions and domain components. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1multicellular organismal water homeostasis (GO:0050891)8.20220350
2keratinocyte differentiation (GO:0030216)8.16743726
3sphingoid metabolic process (GO:0046519)7.99967713
4keratinocyte proliferation (GO:0043616)7.58545834
5hemidesmosome assembly (GO:0031581)7.12041343
6water homeostasis (GO:0030104)6.85113829
7sphingosine metabolic process (GO:0006670)6.77326439
8peptide cross-linking (GO:0018149)6.65683046
9molting cycle (GO:0042303)6.54829431
10hair cycle (GO:0042633)6.54829431
11epidermal cell differentiation (GO:0009913)6.42096473
12diol metabolic process (GO:0034311)6.16068541
13bundle of His cell to Purkinje myocyte communication (GO:0086069)5.97093809
14epidermis development (GO:0008544)5.67336419
15regulation of ruffle assembly (GO:1900027)5.65793151
16detection of bacterium (GO:0016045)5.63552180
17regulation of phospholipase A2 activity (GO:0032429)5.59241251
18long-chain fatty acid biosynthetic process (GO:0042759)5.46686583
19intermediate filament organization (GO:0045109)5.39207850
20regulation of cell proliferation involved in kidney development (GO:1901722)5.24434875
21thyroid hormone generation (GO:0006590)5.05658027
22detection of other organism (GO:0098543)4.79188813
23interferon-gamma secretion (GO:0072643)4.72731914
24fatty acid elongation (GO:0030497)4.71787016
25glucosamine-containing compound catabolic process (GO:1901072)4.70256702
26viral transcription (GO:0019083)4.63285845
27keratinocyte development (GO:0003334)4.51491205
28regulation of transforming growth factor beta1 production (GO:0032908)4.47919767
29gap junction assembly (GO:0016264)4.46402275
30skin morphogenesis (GO:0043589)4.39549855
31translational termination (GO:0006415)4.34587899
32positive regulation of interleukin-8 secretion (GO:2000484)4.19699312
33thyroid hormone metabolic process (GO:0042403)4.18070510
34ectoderm development (GO:0007398)4.17689922
35ribosomal small subunit biogenesis (GO:0042274)4.01271505
36linoleic acid metabolic process (GO:0043651)4.00468916
37regulation of chemokine secretion (GO:0090196)3.98726385
38phosphatidylinositol acyl-chain remodeling (GO:0036149)3.98196915
39positive regulation of glomerulus development (GO:0090193)3.92417837
40prostaglandin biosynthetic process (GO:0001516)3.86452419
41prostanoid biosynthetic process (GO:0046457)3.86452419
42lateral sprouting from an epithelium (GO:0060601)3.84584906
43polarized epithelial cell differentiation (GO:0030859)3.84526117
44cyclooxygenase pathway (GO:0019371)3.74924490
45negative regulation of stress fiber assembly (GO:0051497)3.70779087
46hair follicle morphogenesis (GO:0031069)3.65214958
47regulation of hypersensitivity (GO:0002883)3.63387849
48negative regulation of keratinocyte proliferation (GO:0010839)3.62605694
49positive regulation of epidermal cell differentiation (GO:0045606)3.60300058
50positive regulation of epidermis development (GO:0045684)3.59874160
51chemical homeostasis within a tissue (GO:0048875)3.53588397
52lipoxygenase pathway (GO:0019372)3.50182381
53negative regulation of interferon-gamma production (GO:0032689)3.49661106
54phospholipid scrambling (GO:0017121)3.46284192
55SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.45419381
56phosphatidylserine acyl-chain remodeling (GO:0036150)3.44495464
57positive regulation of chemokine secretion (GO:0090197)3.43650610
58viral life cycle (GO:0019058)3.41613939
59regulation of interleukin-8 secretion (GO:2000482)3.41516518
60protein targeting to ER (GO:0045047)3.41158307
61intermediate filament cytoskeleton organization (GO:0045104)3.39303804
62cotranslational protein targeting to membrane (GO:0006613)3.38363789
63translational elongation (GO:0006414)3.37851975
64primary alcohol catabolic process (GO:0034310)3.33993035
65establishment of protein localization to endoplasmic reticulum (GO:0072599)3.32779689
66regulation of natural killer cell differentiation (GO:0032823)3.32230386
67negative regulation of kidney development (GO:0090185)3.31870520
68intermediate filament-based process (GO:0045103)3.30470888
69gland morphogenesis (GO:0022612)3.30380009
70cellular protein complex disassembly (GO:0043624)3.27088048
71long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.26850366
72regulation of keratinocyte differentiation (GO:0045616)3.26180818
73phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.17754027
74eyelid development in camera-type eye (GO:0061029)3.17483042
75protein localization to endoplasmic reticulum (GO:0070972)3.17309872
76positive regulation of vesicle fusion (GO:0031340)3.16693749
77regulation of keratinocyte proliferation (GO:0010837)3.16607971
78negative regulation of interleukin-2 production (GO:0032703)3.15708374
79negative regulation of T cell mediated immunity (GO:0002710)3.13013065
80prostaglandin metabolic process (GO:0006693)3.06798697
81prostanoid metabolic process (GO:0006692)3.06798697
82planar cell polarity pathway involved in neural tube closure (GO:0090179)3.05944158
83nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.05203471
84phosphatidylglycerol acyl-chain remodeling (GO:0036148)3.05171480
85surfactant homeostasis (GO:0043129)3.05104458
86positive regulation of keratinocyte differentiation (GO:0045618)3.02488213
87regulation of epidermis development (GO:0045682)3.00231956
88ceramide biosynthetic process (GO:0046513)2.99923106
89arachidonic acid secretion (GO:0050482)2.99836965
90icosanoid secretion (GO:0032309)2.99836965
91negative regulation of cell fate specification (GO:0009996)2.98671236
92negative regulation of acute inflammatory response (GO:0002674)2.98657585
93sphingolipid biosynthetic process (GO:0030148)2.97742187
94intestinal epithelial cell development (GO:0060576)2.97377051
95phosphatidylserine metabolic process (GO:0006658)2.96331258
96G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.95323629
97phosphatidylcholine acyl-chain remodeling (GO:0036151)2.95207792
98establishment of tissue polarity (GO:0007164)2.93693510
99establishment of planar polarity (GO:0001736)2.93693510
100retinol metabolic process (GO:0042572)2.92247161
101cardiac right ventricle morphogenesis (GO:0003215)2.91881092
102regulation of epidermal cell differentiation (GO:0045604)2.91533000
103regulation of glomerulus development (GO:0090192)2.85222382
104regulation of glomerular filtration (GO:0003093)2.84821784
105atrioventricular valve morphogenesis (GO:0003181)2.82166222
106hair cycle process (GO:0022405)2.81848321
107molting cycle process (GO:0022404)2.81848321
108ribosomal small subunit assembly (GO:0000028)2.80877523
109maturation of SSU-rRNA (GO:0030490)2.80695980
110epithelium development (GO:0060429)2.79501903
111positive regulation of interleukin-4 production (GO:0032753)2.78381331
112regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.75365672
113negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.74232105
114regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.72992167
115phospholipid catabolic process (GO:0009395)2.72311077
116negative regulation of cell fate commitment (GO:0010454)2.70775579
117ventricular cardiac muscle cell action potential (GO:0086005)2.68206629
118regulation of cardioblast differentiation (GO:0051890)2.64825269
119skin development (GO:0043588)2.60140927
120epithelial cell differentiation involved in prostate gland development (GO:0060742)2.56514927
121regulation of hair cycle (GO:0042634)2.55461168
122regulation of hair follicle development (GO:0051797)2.50125735
123regulation of heart rate by cardiac conduction (GO:0086091)2.46287461
124regulation of mitochondrial translation (GO:0070129)2.45359388
125negative regulation of epidermis development (GO:0045683)2.40687259
126positive regulation of cellular amide metabolic process (GO:0034250)2.36004519
127alditol phosphate metabolic process (GO:0052646)2.32841916
128defense response to fungus (GO:0050832)2.32484598
129cell-cell junction assembly (GO:0007043)2.31304021
130long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.30759675
131protein complex localization (GO:0031503)2.29047345
132hair cell differentiation (GO:0035315)2.28710918
133cellular protein complex localization (GO:0034629)2.28001715
134regulation of mesoderm development (GO:2000380)2.27162102
135epithelial cell-cell adhesion (GO:0090136)2.25936804
136regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.24756530
137epithelial cell differentiation (GO:0030855)2.24133142
138mitotic G1 DNA damage checkpoint (GO:0031571)2.18178875
139regulation of neuron projection regeneration (GO:0070570)2.15118111
140regulation of axon regeneration (GO:0048679)2.15118111
141cellular component disassembly involved in execution phase of apoptosis (GO:0006921)2.14156415
142primary alcohol metabolic process (GO:0034308)2.13986892
143positive regulation of hair follicle development (GO:0051798)2.12022823
144positive regulation of hair cycle (GO:0042635)2.12022823
145desmosome organization (GO:0002934)16.1620851
146establishment of skin barrier (GO:0061436)13.3896060
147regulation of water loss via skin (GO:0033561)12.1501678
148keratinization (GO:0031424)11.6840066

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse6.40440892
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.80134750
3P63_26484246_Chip-Seq_KERATINOCYTES_Human3.17055083
4* SOX9_24532713_ChIP-Seq_HFSC_Mouse3.00725364
5CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.42187357
6ZNF263_19887448_ChIP-Seq_K562_Human2.33908161
7ESR1_21235772_ChIP-Seq_MCF-7_Human2.31514947
8SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.26000096
9TRIM28_21343339_ChIP-Seq_HEK293_Human2.17328954
10STAT6_21828071_ChIP-Seq_BEAS2B_Human2.07330815
11MYC_18555785_ChIP-Seq_MESCs_Mouse2.01726797
12TP63_17297297_ChIP-ChIP_HaCaT_Human15.8078827
13SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.94131537
14SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.94131537
15ESR2_21235772_ChIP-Seq_MCF-7_Human1.92318902
16PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.87468418
17FOXO3_23340844_ChIP-Seq_DLD1_Human1.72920281
18MYC_19079543_ChIP-ChIP_MESCs_Mouse1.56862242
19ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.56447437
20AR_21909140_ChIP-Seq_LNCAP_Human1.54798540
21NANOG_18555785_ChIP-Seq_MESCs_Mouse1.52644092
22KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.52431287
23TCF4_18268006_ChIP-ChIP_LS174T_Human1.51043721
24TP63_23658742_ChIP-Seq_EP156T_Human1.50933997
25ZNF217_24962896_ChIP-Seq_MCF-7_Human1.50214325
26SOX2_20726797_ChIP-Seq_SW620_Human1.48696638
27TP63_22573176_ChIP-Seq_HFKS_Human1.33293301
28BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.31166620
29CJUN_26792858_Chip-Seq_BT549_Human1.28111610
30TP53_18474530_ChIP-ChIP_U2OS_Human1.25884746
31SRY_22984422_ChIP-ChIP_TESTIS_Rat1.25740428
32GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.24469993
33ERG_20517297_ChIP-Seq_VCAP_Human1.22354613
34AR_21572438_ChIP-Seq_LNCaP_Human1.22196823
35MYC_19030024_ChIP-ChIP_MESCs_Mouse1.21304617
36RUNX1_27514584_Chip-Seq_MCF-7_Human1.19831141
37TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.18759675
38KLF5_25053715_ChIP-Seq_YYC3_Human1.18585454
39GABP_17652178_ChIP-ChIP_JURKAT_Human1.18055115
40MYC_18358816_ChIP-ChIP_MESCs_Mouse1.17190080
41HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.16353755
42RXR_22108803_ChIP-Seq_LS180_Human1.15709588
43STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.15051495
44TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14478918
45KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.14167599
46NELFA_20434984_ChIP-Seq_ESCs_Mouse1.10743700
47E2F7_22180533_ChIP-Seq_HELA_Human1.10549690
48GATA3_24758297_ChIP-Seq_MCF-7_Human1.07227988
49TP53_20018659_ChIP-ChIP_R1E_Mouse1.07191721
50CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.06806283
51HIF1A_21447827_ChIP-Seq_MCF-7_Human1.04962056
52GATA6_21074721_ChIP-Seq_CACO-2_Human1.04908444
53CREB1_15753290_ChIP-ChIP_HEK293T_Human1.04109616
54POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.03837558
55TCF3_18692474_ChIP-Seq_MEFs_Mouse1.01856068
56JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.00451990
57CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.98335579
58CEBPB_22108803_ChIP-Seq_LS180_Human0.98137289
59* GATA4_25053715_ChIP-Seq_YYC3_Human0.97631109
60KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.96762948
61EZH2_27304074_Chip-Seq_ESCs_Mouse0.96193980
62SUZ12_27294783_Chip-Seq_ESCs_Mouse0.95923894
63XRN2_22483619_ChIP-Seq_HELA_Human0.95895542
64E2F1_18555785_ChIP-Seq_MESCs_Mouse0.95471250
65RACK7_27058665_Chip-Seq_MCF-7_Human0.94591645
66ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.94315087
67AHR_22903824_ChIP-Seq_MCF-7_Human0.94058049
68P53_21459846_ChIP-Seq_SAOS-2_Human0.93807618
69ATF3_27146783_Chip-Seq_COLON_Human0.93544573
70BCAT_22108803_ChIP-Seq_LS180_Human0.92100881
71PADI4_21655091_ChIP-ChIP_MCF-7_Human0.92059218
72HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.91472931
73EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.90975663
74CDX2_20551321_ChIP-Seq_CACO-2_Human0.90698943
75NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.90502442
76EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.90375090
77CHD1_26751641_Chip-Seq_LNCaP_Human0.88653626
78SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.88369316
79DCP1A_22483619_ChIP-Seq_HELA_Human0.87972405
80NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.87735619
81E2F1_20622854_ChIP-Seq_HELA_Human0.87717752
82EED_16625203_ChIP-ChIP_MESCs_Mouse0.87682092
83SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.86887594
84UBF1/2_26484160_Chip-Seq_HMECs_Human0.85672243
85PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.84783692
86HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.84712584
87P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.84473754
88RARG_19884340_ChIP-ChIP_MEFs_Mouse0.84206745
89TCF4_22108803_ChIP-Seq_LS180_Human0.84189674
90* TCF3_18692474_ChIP-Seq_MESCs_Mouse0.83917674
91FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.83576998
92GATA1_22025678_ChIP-Seq_K562_Human0.83486291
93KLF4_18555785_ChIP-Seq_MESCs_Mouse0.83369867
94CTCF_27219007_Chip-Seq_Bcells_Human0.82244683
95FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.81729705
96ETS1_20019798_ChIP-Seq_JURKAT_Human0.81503808
97PPAR_26484153_Chip-Seq_NCI-H1993_Human0.81152921
98CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.80986428
99FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.80192736
100KAP1_27257070_Chip-Seq_ESCs_Mouse0.79850080
101FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.79594665
102SA1_27219007_Chip-Seq_ERYTHROID_Human0.79265457
103EZH2_27294783_Chip-Seq_ESCs_Mouse0.78793904
104JARID2_20075857_ChIP-Seq_MESCs_Mouse0.78686931
105VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.77922983
106BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.77592932
107BMI1_23680149_ChIP-Seq_NPCS_Mouse0.77303749
108UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.76628849
109KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.76018190
110ERG_21242973_ChIP-ChIP_JURKAT_Human0.75099114
111CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.75085426
112EST1_17652178_ChIP-ChIP_JURKAT_Human0.75035001
113FOXM1_26456572_ChIP-Seq_MCF-7_Human0.73840464
114SMC4_20622854_ChIP-Seq_HELA_Human0.73762380
115SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.73208468
116ESR1_20079471_ChIP-ChIP_T-47D_Human0.73081690
117TTF2_22483619_ChIP-Seq_HELA_Human0.72659767
118JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.72024171
119P68_20966046_ChIP-Seq_HELA_Human0.72015697
120RBPJ_21746931_ChIP-Seq_IB4_Human0.71151281
121BCOR_27268052_Chip-Seq_Bcells_Human0.70657303
122SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.70186849
123ARNT_22903824_ChIP-Seq_MCF-7_Human0.69813295
124AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.69529112
125SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.69257298
126SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.67598872
127ELK1_22589737_ChIP-Seq_MCF10A_Human0.67596078
128* GATA6_25053715_ChIP-Seq_YYC3_Human0.67445465
129SOX2_27498859_Chip-Seq_STOMACH_Mouse0.67008756
130PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.66657053
131HNFA_21074721_ChIP-Seq_CACO-2_Human0.66579527
132ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.66540072
133RNF2_27304074_Chip-Seq_ESCs_Mouse0.66362680
134SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.66278787
135VDR_22108803_ChIP-Seq_LS180_Human0.65573355
136SA1_27219007_Chip-Seq_Bcells_Human0.65400400
137GATA3_21867929_ChIP-Seq_TH1_Mouse0.65244256
138* LXR_22292898_ChIP-Seq_THP-1_Human0.65127217
139AUTS2_25519132_ChIP-Seq_293T-REX_Human0.64115346
140EZH2_18974828_ChIP-Seq_MESCs_Mouse0.63657067
141RNF2_18974828_ChIP-Seq_MESCs_Mouse0.63657067
142JARID2_20064375_ChIP-Seq_MESCs_Mouse0.63578156
143YY1_22570637_ChIP-Seq_MALME-3M_Human0.62617749
144DNAJC2_21179169_ChIP-ChIP_NT2_Human0.61803565
145EGR1_19032775_ChIP-ChIP_M12_Human0.61793247
146CTCF_20526341_ChIP-Seq_ESCs_Human0.61702506
147PHF8_20622853_ChIP-Seq_HELA_Human0.61411944
148FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.61392845
149NANOG_20526341_ChIP-Seq_ESCs_Human0.60667470
150FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.60363256

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier8.21484180
2MP0005275_abnormal_skin_tensile5.72005730
3MP0003941_abnormal_skin_development5.58662442
4MP0010234_abnormal_vibrissa_follicle5.57317665
5MP0005501_abnormal_skin_physiology5.09132763
6MP0004381_abnormal_hair_follicle4.20899266
7MP0002060_abnormal_skin_morphology3.68243385
8MP0001216_abnormal_epidermal_layer3.58894561
9MP0010771_integument_phenotype3.25851583
10MP0000579_abnormal_nail_morphology3.24033423
11MP0000383_abnormal_hair_follicle3.16777705
12MP0003453_abnormal_keratinocyte_physiol3.09855582
13MP0010678_abnormal_skin_adnexa3.09699494
14MP0005451_abnormal_body_composition2.99699197
15MP0002254_reproductive_system_inflammat2.96403662
16MP0002098_abnormal_vibrissa_morphology2.91795929
17MP0004947_skin_inflammation2.61595955
18MP0000647_abnormal_sebaceous_gland2.60940064
19MP0001188_hyperpigmentation2.58808339
20MP0000467_abnormal_esophagus_morphology2.45826387
21MP0000377_abnormal_hair_follicle2.39738378
22MP0000566_synostosis2.38904898
23MP0000427_abnormal_hair_cycle2.08414819
24MP0002009_preneoplasia1.97693244
25MP0003878_abnormal_ear_physiology1.87765078
26MP0005377_hearing/vestibular/ear_phenot1.87765078
27MP0003705_abnormal_hypodermis_morpholog1.85047600
28MP0009931_abnormal_skin_appearance1.77495106
29MP0003566_abnormal_cell_adhesion1.75490033
30MP0000762_abnormal_tongue_morphology1.75331909
31MP0001191_abnormal_skin_condition1.71877463
32MP0004885_abnormal_endolymph1.67270831
33MP0001346_abnormal_lacrimal_gland1.53977818
34MP0004185_abnormal_adipocyte_glucose1.53149348
35MP0009379_abnormal_foot_pigmentation1.49980468
36MP0000367_abnormal_coat/_hair1.38128140
37MP0001243_abnormal_dermal_layer1.34873547
38MP0003011_delayed_dark_adaptation1.24237040
39MP0003191_abnormal_cellular_cholesterol1.21705685
40MP0001851_eye_inflammation1.19759644
41MP0002234_abnormal_pharynx_morphology1.16500954
42MP0004782_abnormal_surfactant_physiolog1.12255304
43MP0003136_yellow_coat_color1.08279672
44MP0005174_abnormal_tail_pigmentation1.06350392
45MP0001340_abnormal_eyelid_morphology1.03950666
46MP0000465_gastrointestinal_hemorrhage0.97240007
47MP0000015_abnormal_ear_pigmentation0.96117660
48MP0010352_gastrointestinal_tract_polyps0.90457972
49MP0008004_abnormal_stomach_pH0.90008143
50MP0009053_abnormal_anal_canal0.83194900
51MP0004957_abnormal_blastocyst_morpholog0.80876956
52MP0002177_abnormal_outer_ear0.75163528
53MP0003315_abnormal_perineum_morphology0.74727710
54MP0005023_abnormal_wound_healing0.68570769
55MP0002006_tumorigenesis0.67643264
56MP0002166_altered_tumor_susceptibility0.67394410
57MP0003693_abnormal_embryo_hatching0.64343884
58MP0000537_abnormal_urethra_morphology0.63667586
59MP0002249_abnormal_larynx_morphology0.61829459
60MP0000627_abnormal_mammary_gland0.61807837
61MP0005367_renal/urinary_system_phenotyp0.61409693
62MP0000516_abnormal_urinary_system0.61409693
63MP0004019_abnormal_vitamin_homeostasis0.60656401
64MP0002697_abnormal_eye_size0.58754996
65MP0001984_abnormal_olfaction0.58122398
66MP0001485_abnormal_pinna_reflex0.57903790
67MP0009672_abnormal_birth_weight0.57700859
68MP0001784_abnormal_fluid_regulation0.56496034
69MP0002277_abnormal_respiratory_mucosa0.55966339
70MP0006054_spinal_hemorrhage0.55747119
71MP0003890_abnormal_embryonic-extraembry0.54990426
72MP0000681_abnormal_thyroid_gland0.54438024
73MP0005075_abnormal_melanosome_morpholog0.53923888
74MP0005076_abnormal_cell_differentiation0.53272405
75MP0002877_abnormal_melanocyte_morpholog0.53032849
76MP0009780_abnormal_chondrocyte_physiolo0.52583604
77MP0010030_abnormal_orbit_morphology0.51265843
78MP0005409_darkened_coat_color0.49972808
79MP0003937_abnormal_limbs/digits/tail_de0.49335721
80MP0009384_cardiac_valve_regurgitation0.46609875
81MP0002095_abnormal_skin_pigmentation0.46571848
82MP0003950_abnormal_plasma_membrane0.45839109
83MP0002282_abnormal_trachea_morphology0.45190654
84MP0003755_abnormal_palate_morphology0.44700757
85MP0003763_abnormal_thymus_physiology0.44400474
86MP0005394_taste/olfaction_phenotype0.44333059
87MP0005499_abnormal_olfactory_system0.44333059
88MP0005508_abnormal_skeleton_morphology0.43773637
89MP0002111_abnormal_tail_morphology0.42572841
90MP0003436_decreased_susceptibility_to0.41832566
91MP0001299_abnormal_eye_distance/0.40886656
92MP0002233_abnormal_nose_morphology0.40265551
93MP0000538_abnormal_urinary_bladder0.39618907
94MP0003638_abnormal_response/metabolism_0.39408051
95MP0004043_abnormal_pH_regulation0.39268062
96MP0003786_premature_aging0.37890628
97MP0001849_ear_inflammation0.37645249
98MP0002148_abnormal_hypersensitivity_rea0.36952994
99MP0004197_abnormal_fetal_growth/weight/0.36373053
100MP0008932_abnormal_embryonic_tissue0.35842382
101MP0009697_abnormal_copulation0.35432106
102MP0010094_abnormal_chromosome_stability0.35393014
103MP0004264_abnormal_extraembryonic_tissu0.35378457
104MP0002084_abnormal_developmental_patter0.35205744
105MP0003111_abnormal_nucleus_morphology0.34777360
106MP0001293_anophthalmia0.34468169
107MP0001286_abnormal_eye_development0.34102329
108MP0000428_abnormal_craniofacial_morphol0.32665180
109MP0001177_atelectasis0.32285730
110MP0010386_abnormal_urinary_bladder0.31623184
111MP0000470_abnormal_stomach_morphology0.30257366
112MP0002090_abnormal_vision0.30142489
113MP0005666_abnormal_adipose_tissue0.29995943
114MP0001186_pigmentation_phenotype0.29889293
115MP0000462_abnormal_digestive_system0.29614438
116MP0003718_maternal_effect0.29223257
117MP0002938_white_spotting0.28795253
118MP0002132_abnormal_respiratory_system0.28552461
119MP0000049_abnormal_middle_ear0.28287184
120MP0005257_abnormal_intraocular_pressure0.28219311
121MP0004272_abnormal_basement_membrane0.28067085
122MP0005408_hypopigmentation0.26749484
123MP0003938_abnormal_ear_development0.25595409
124MP0000613_abnormal_salivary_gland0.25455071
125MP0009250_abnormal_appendicular_skeleto0.24199041
126MP0005187_abnormal_penis_morphology0.23645167
127MP0000432_abnormal_head_morphology0.22700600
128MP0008961_abnormal_basal_metabolism0.22168204
129MP0008789_abnormal_olfactory_epithelium0.21158765
130MP0005390_skeleton_phenotype0.20645108
131MP0001666_abnormal_nutrient_absorption0.18728282
132MP0005375_adipose_tissue_phenotype0.18678615
133MP0001919_abnormal_reproductive_system0.17663905
134MP0002109_abnormal_limb_morphology0.17630708
135MP0001542_abnormal_bone_strength0.15643650
136MP0003385_abnormal_body_wall0.14530804

Predicted human phenotypes

RankGene SetZ-score
1Hypotrichosis (HP:0001006)7.49477725
2Congenital ichthyosiform erythroderma (HP:0007431)7.21183234
3Congenital nonbullous ichthyosiform erythroderma (HP:0007479)7.14476694
4Increased IgE level (HP:0003212)6.68673250
5Plantar hyperkeratosis (HP:0007556)6.59744205
6Parakeratosis (HP:0001036)6.54712655
7Palmoplantar hyperkeratosis (HP:0000972)6.34374000
8Erythema (HP:0010783)6.21611491
9Woolly hair (HP:0002224)6.16506898
10Abnormality of nail color (HP:0100643)6.14401311
11Palmar hyperkeratosis (HP:0010765)5.95795171
12Lip pit (HP:0100267)5.94972407
13Erythroderma (HP:0001019)5.94390618
14Right ventricular cardiomyopathy (HP:0011663)5.74988812
15Oral leukoplakia (HP:0002745)5.51912946
16Fragile nails (HP:0001808)5.27731779
17Onycholysis (HP:0001806)5.06761223
18Conjunctival hamartoma (HP:0100780)4.82877353
19Abnormality of the axillary hair (HP:0100134)4.31512789
20Abnormality of secondary sexual hair (HP:0009888)4.31512789
21Abnormal blistering of the skin (HP:0008066)4.29134287
22Thick nail (HP:0001805)4.12790096
23Ectropion (HP:0000656)4.08865457
24Corneal erosion (HP:0200020)3.99889934
25Milia (HP:0001056)3.97004370
26Gangrene (HP:0100758)3.91904245
27Hypohidrosis (HP:0000966)3.81711308
28Absent eyelashes (HP:0000561)3.79075747
29Popliteal pterygium (HP:0009756)3.66843164
30Pili torti (HP:0003777)3.63999648
31Natal tooth (HP:0000695)3.55498623
32Sparse eyelashes (HP:0000653)3.44604914
33Sparse scalp hair (HP:0002209)3.41688662
34Pruritus (HP:0000989)3.40236521
35Palmoplantar keratoderma (HP:0000982)3.37735765
36Nail dystrophy (HP:0008404)3.34171001
37Hyporeflexia of lower limbs (HP:0002600)3.29314795
38Absent hair (HP:0002298)3.17098330
39Distal lower limb muscle weakness (HP:0009053)3.13830333
40Curly hair (HP:0002212)3.13153308
41Advanced eruption of teeth (HP:0006288)3.12965006
42Acanthosis nigricans (HP:0000956)3.05987941
43Ventricular tachycardia (HP:0004756)2.99800144
44Abnormality of the salivary glands (HP:0010286)2.92948139
45Concave nail (HP:0001598)2.78143043
46Follicular hyperkeratosis (HP:0007502)2.73577633
47Hypoplastic labia majora (HP:0000059)2.73034953
48Abnormality of cells of the erythroid lineage (HP:0012130)2.72848013
49Selective tooth agenesis (HP:0001592)2.71680253
50Hamartoma of the eye (HP:0010568)2.71408724
51Furrowed tongue (HP:0000221)2.60412849
52Alopecia of scalp (HP:0002293)2.56377008
53Ridged nail (HP:0001807)2.52506263
54Abnormality of the labia majora (HP:0012881)2.47562386
55Abnormal hair laboratory examination (HP:0003328)2.36410123
56Oligodontia (HP:0000677)2.35171569
57Slow-growing hair (HP:0002217)2.33726117
58Abnormality of hair growth rate (HP:0011363)2.33726117
59Areflexia of lower limbs (HP:0002522)2.32233805
60Abnormality of permanent molar morphology (HP:0011071)2.29691078
61Abnormality of the dental root (HP:0006486)2.29691078
62Taurodontia (HP:0000679)2.29691078
63Dry skin (HP:0000958)2.28891174
64Abnormal hemoglobin (HP:0011902)2.28583341
65Congenital, generalized hypertrichosis (HP:0004540)2.25743391
66Brittle hair (HP:0002299)2.25696883
67Reticulocytopenia (HP:0001896)2.23468208
68Severe Myopia (HP:0011003)2.19442308
69Abnormal number of erythroid precursors (HP:0012131)2.18605331
70Atrophic scars (HP:0001075)2.17615518
71Lack of skin elasticity (HP:0100679)2.15456785
72Pterygium (HP:0001059)2.14438113
73Abnormality of molar (HP:0011077)2.10953937
74Abnormality of molar morphology (HP:0011070)2.10953937
75Dry hair (HP:0011359)2.10301054
76Dehydration (HP:0001944)2.09784756
77Ventricular fibrillation (HP:0001663)2.08248717
78Down-sloping shoulders (HP:0200021)2.07380688
79Anhidrosis (HP:0000970)2.03505141
80Abnormality of the dental pulp (HP:0006479)2.03403369
81Hypergammaglobulinemia (HP:0010702)2.02935121
82Amniotic constriction ring (HP:0009775)2.02812347
83Abnormality of placental membranes (HP:0011409)2.02812347
84Septate vagina (HP:0001153)2.01172480
85Blepharitis (HP:0000498)2.00431530
86Laryngomalacia (HP:0001601)1.98740136
87Nasolacrimal duct obstruction (HP:0000579)1.97839044
88Pustule (HP:0200039)1.97798929
89Abnormality of the gastric mucosa (HP:0004295)1.96117734
90Fatigable weakness (HP:0003473)1.92158477
91Abnormality of the neuromuscular junction (HP:0003398)1.92158477
92Hypodontia (HP:0000668)1.89658534
93Corneal dystrophy (HP:0001131)1.89639810
94Melanocytic nevus (HP:0000995)1.84853136
95Abnormality of the lacrimal duct (HP:0011481)1.81609005
96Macrocytic anemia (HP:0001972)1.81499939
97Skin pits (HP:0100276)1.80897115
98Absent eyebrow (HP:0002223)1.79345327
99Malignant hyperthermia (HP:0002047)1.77808758
100Abnormality of the distal phalanges of the toes (HP:0010182)1.77725024
101Skin ulcer (HP:0200042)1.77333305
102Duplicated collecting system (HP:0000081)1.76022545
103Labial hypoplasia (HP:0000066)1.74834543
104Aplasia involving bones of the upper limbs (HP:0009823)1.74144095
105Aplasia of the phalanges of the hand (HP:0009802)1.74144095
106Aplasia involving bones of the extremities (HP:0009825)1.74144095
107Chronic bronchitis (HP:0004469)1.72727447
108Stenosis of the external auditory canal (HP:0000402)1.68527485
109Hypoparathyroidism (HP:0000829)1.68082263
110Conical tooth (HP:0000698)1.66464203
111Hyperhidrosis (HP:0000975)1.66231584
112Hypoplasia of dental enamel (HP:0006297)1.64396978
113Aplasia cutis congenita (HP:0001057)1.62671208
114Breast hypoplasia (HP:0003187)1.60721465
115Fine hair (HP:0002213)1.60673626
116Hypoplastic female external genitalia (HP:0012815)1.59765815
117Trismus (HP:0000211)1.59661377
118Carious teeth (HP:0000670)1.59292184
119Neonatal death (HP:0003811)1.58889840
120Multifactorial inheritance (HP:0001426)1.58242333
121Ulnar claw (HP:0001178)1.55702374
122Bifid scrotum (HP:0000048)1.54749956
123Anonychia (HP:0001798)1.54711373
124Increased connective tissue (HP:0009025)1.54666444
125Abnormality of the nasolacrimal system (HP:0000614)1.52573260
126Pallor (HP:0000980)1.51291514
127Split foot (HP:0001839)1.49521402
128Recurrent corneal erosions (HP:0000495)1.48962917
129Goiter (HP:0000853)1.48564666
130Achilles tendon contracture (HP:0001771)1.48529609
131Hamartoma (HP:0010566)1.48418021
132Abnormality of the renal collecting system (HP:0004742)1.48044831
133Abnormality of small intestinal villus morphology (HP:0011472)1.37544994
134Villous atrophy (HP:0011473)1.37544994
135Abnormality of the fingernails (HP:0001231)1.37254761

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R6.02557787
2MAPKAPK34.81943942
3MST44.58783322
4MAP3K34.46354064
5FER3.42815812
6MAP3K23.39782484
7PBK3.00081088
8TGFBR12.99224016
9VRK22.55393568
10RPS6KB22.51984296
11EPHB22.40745337
12TRPM72.38209831
13TAF12.31105902
14BUB12.31021532
15SMG12.28495956
16PIM22.20973856
17LATS12.19164422
18STK242.15464052
19NME11.98906156
20ERBB31.95764557
21MET1.91392879
22ERN11.87876426
23TTK1.85690824
24MAPKAPK51.82928449
25PIK3CG1.66752986
26LRRK21.59884225
27ZAK1.45493226
28STK31.44345412
29FGFR21.36817407
30STK101.36661916
31BCR1.34347797
32STK161.32916975
33TESK11.21742808
34SRPK11.17168246
35NTRK21.14656169
36MAP2K61.13980567
37BLK1.12489203
38RIPK41.12199906
39MAP3K111.10371223
40EPHA31.07487176
41ABL21.06711107
42CDC71.06338337
43FGFR41.05995030
44EEF2K1.05254883
45DYRK1B1.04775097
46EPHA21.03862654
47GRK11.02872848
48TSSK60.99676659
49MAP3K120.99603947
50PAK40.97873309
51MAP3K10.95722882
52MAP3K140.95625848
53TNK20.90190223
54PTK60.88554999
55LATS20.88417569
56PTK20.88409827
57TRIB30.86051240
58FGFR30.84364008
59MKNK20.84184884
60FGFR10.84065563
61VRK10.83341431
62BMPR1B0.82665359
63MAPKAPK20.82550065
64GRK70.76553363
65TGFBR20.75669034
66ITK0.75129037
67EIF2AK30.74113813
68EIF2AK10.71789973
69MAP3K70.68792777
70TTN0.66286750
71PLK30.64932451
72TAOK10.64677403
73DYRK30.64474773
74MAP3K60.63702227
75SGK4940.63408747
76SGK2230.63408747
77LIMK10.63278126
78PLK10.61475353
79OBSCN0.59753421
80AURKB0.58632513
81CDK60.58531637
82CDK70.57561133
83BRSK20.57201564
84CDK120.57121979
85TYK20.56504192
86PRKD10.54615313
87STK38L0.54524476
88MAPK150.53870762
89NME20.53868890
90ADRBK10.49888697
91ILK0.49842031
92NUAK10.49832992
93NLK0.48539910
94MELK0.48404598
95PDK20.48321944
96EIF2AK20.47831960
97CDK30.47603758
98EPHA40.47574830
99CSNK1E0.47519740
100MKNK10.47230527
101CSNK1G10.44648754
102YES10.44631059
103PRKCE0.43705636
104CHEK20.43662403
105MAP2K40.43191950
106MAP2K30.42923462
107CASK0.41795419
108PRKCI0.41610112
109MAP3K50.41180420
110TYRO30.39799847
111PKN10.39450441
112RPS6KA40.39312963
113AKT30.38570805
114IRAK30.38394494
115PLK40.38172534
116FLT30.37783600
117STK40.37346462
118CSNK1A1L0.37235070
119CSNK1D0.37118995
120STK110.37028804
121IRAK10.36940152
122IKBKB0.36848341
123WEE10.36438199
124EPHB10.36258775
125MYLK0.35831144
126ROCK10.35720862
127GRK50.35181694
128RPS6KB10.34450292
129HIPK20.33397723
130IKBKE0.32998608
131MTOR0.32269078
132MAP2K10.32197086
133DYRK20.31632353
134CDK190.31620791
135NEK10.30586805
136RIPK10.30331833
137BMX0.30284949
138MAP2K20.30054745
139PAK30.29315359
140JAK20.29237753
141HCK0.28400865
142CHEK10.27513539
143MAPK40.27008631
144ERBB20.26870833
145ABL10.26408002
146RPS6KA10.26344891
147MAP3K90.26314147
148PRKG20.25126219
149MAPK120.24982892
150CSNK1G30.24721040
151BRAF0.24567853
152ATM0.24418383
153ERBB40.23562363
154PRKAA20.23081313
155SYK0.22176863
156MOS0.21207096
157RPS6KA20.21144532
158SRC0.20996266
159AURKA0.20701544
160ROCK20.20308842

Predicted pathways (KEGG)

RankGene SetZ-score
1Sphingolipid metabolism_Homo sapiens_hsa006004.49287902
2Ribosome_Homo sapiens_hsa030104.08603299
3Cyanoamino acid metabolism_Homo sapiens_hsa004603.80550403
4Linoleic acid metabolism_Homo sapiens_hsa005913.62983113
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.48516022
6Arachidonic acid metabolism_Homo sapiens_hsa005903.26572012
7Fatty acid elongation_Homo sapiens_hsa000622.66494933
8Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.64095833
9Proteasome_Homo sapiens_hsa030502.42972406
10Phenylalanine metabolism_Homo sapiens_hsa003602.38866406
11Histidine metabolism_Homo sapiens_hsa003402.29411931
12Ether lipid metabolism_Homo sapiens_hsa005652.20542028
13Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.07833684
14Oxidative phosphorylation_Homo sapiens_hsa001901.86816413
15Retinol metabolism_Homo sapiens_hsa008301.74028303
16Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.73698863
17RNA polymerase_Homo sapiens_hsa030201.69303332
18Mismatch repair_Homo sapiens_hsa034301.68768604
19Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.63515028
20DNA replication_Homo sapiens_hsa030301.46614311
21Staphylococcus aureus infection_Homo sapiens_hsa051501.45183375
22VEGF signaling pathway_Homo sapiens_hsa043701.44568140
23Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.44108580
24Basal cell carcinoma_Homo sapiens_hsa052171.44057233
25Sphingolipid signaling pathway_Homo sapiens_hsa040711.42742292
26Chemical carcinogenesis_Homo sapiens_hsa052041.42114269
27Tyrosine metabolism_Homo sapiens_hsa003501.39354902
28Tight junction_Homo sapiens_hsa045301.36557749
29Huntingtons disease_Homo sapiens_hsa050161.31916578
30Axon guidance_Homo sapiens_hsa043601.31291608
31Adherens junction_Homo sapiens_hsa045201.26966744
32RNA transport_Homo sapiens_hsa030131.22333643
33Parkinsons disease_Homo sapiens_hsa050121.21953501
34p53 signaling pathway_Homo sapiens_hsa041151.17766699
35GnRH signaling pathway_Homo sapiens_hsa049121.12470256
36ABC transporters_Homo sapiens_hsa020101.12143743
37Phototransduction_Homo sapiens_hsa047441.11973316
38Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.11966291
39Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.09092705
40Renin secretion_Homo sapiens_hsa049241.07361002
41Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.07165365
42Spliceosome_Homo sapiens_hsa030401.05005529
43Protein export_Homo sapiens_hsa030601.01693853
44ECM-receptor interaction_Homo sapiens_hsa045120.99337084
45Serotonergic synapse_Homo sapiens_hsa047260.98384976
46One carbon pool by folate_Homo sapiens_hsa006700.95911346
47Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.95808502
48Hippo signaling pathway_Homo sapiens_hsa043900.94056136
49Nucleotide excision repair_Homo sapiens_hsa034200.93641172
50Hedgehog signaling pathway_Homo sapiens_hsa043400.92015203
51Pancreatic secretion_Homo sapiens_hsa049720.91850578
52Melanogenesis_Homo sapiens_hsa049160.91771144
53Bladder cancer_Homo sapiens_hsa052190.90063422
54Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.88564490
55Pyruvate metabolism_Homo sapiens_hsa006200.87889530
56Pyrimidine metabolism_Homo sapiens_hsa002400.85902202
57Vitamin B6 metabolism_Homo sapiens_hsa007500.85219104
58Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.84687984
59Fat digestion and absorption_Homo sapiens_hsa049750.83843639
60Proteoglycans in cancer_Homo sapiens_hsa052050.82968177
61Homologous recombination_Homo sapiens_hsa034400.82303085
62beta-Alanine metabolism_Homo sapiens_hsa004100.79119919
63Leukocyte transendothelial migration_Homo sapiens_hsa046700.78670517
64Basal transcription factors_Homo sapiens_hsa030220.77282241
65Caffeine metabolism_Homo sapiens_hsa002320.77027568
66Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.75773748
67Pertussis_Homo sapiens_hsa051330.75707260
68Cell cycle_Homo sapiens_hsa041100.75253650
69Ovarian steroidogenesis_Homo sapiens_hsa049130.74850432
70Hepatitis C_Homo sapiens_hsa051600.74357557
71Long-term depression_Homo sapiens_hsa047300.74356939
72Thyroid hormone synthesis_Homo sapiens_hsa049180.74308025
73Pentose and glucuronate interconversions_Homo sapiens_hsa000400.74120636
74Sulfur relay system_Homo sapiens_hsa041220.73816483
75Ras signaling pathway_Homo sapiens_hsa040140.73214085
76Cysteine and methionine metabolism_Homo sapiens_hsa002700.73198781
77Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.71810083
78Glutathione metabolism_Homo sapiens_hsa004800.71006047
79Arginine and proline metabolism_Homo sapiens_hsa003300.70527765
80Collecting duct acid secretion_Homo sapiens_hsa049660.70199782
81RNA degradation_Homo sapiens_hsa030180.69300635
82Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.69262637
83Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.68998158
84Glycerophospholipid metabolism_Homo sapiens_hsa005640.68874439
85Metabolic pathways_Homo sapiens_hsa011000.68698884
86Vascular smooth muscle contraction_Homo sapiens_hsa042700.67977690
87Platelet activation_Homo sapiens_hsa046110.63628395
88Fatty acid biosynthesis_Homo sapiens_hsa000610.63498495
89MicroRNAs in cancer_Homo sapiens_hsa052060.62836291
90Mineral absorption_Homo sapiens_hsa049780.61897673
91Base excision repair_Homo sapiens_hsa034100.60954560
92Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.60931405
93Gastric acid secretion_Homo sapiens_hsa049710.60241150
94Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.59934458
95Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.58155316
96Amoebiasis_Homo sapiens_hsa051460.58088718
97Steroid biosynthesis_Homo sapiens_hsa001000.57145318
98Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.55790751
99Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.55592938
100Jak-STAT signaling pathway_Homo sapiens_hsa046300.54737203
1012-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.53946999
102Thyroid cancer_Homo sapiens_hsa052160.52879427
103NOD-like receptor signaling pathway_Homo sapiens_hsa046210.51278643
104TGF-beta signaling pathway_Homo sapiens_hsa043500.50665423
105ErbB signaling pathway_Homo sapiens_hsa040120.49368693
106Arginine biosynthesis_Homo sapiens_hsa002200.49248349
107Wnt signaling pathway_Homo sapiens_hsa043100.48586998
108Fatty acid degradation_Homo sapiens_hsa000710.45975931
109Glycerolipid metabolism_Homo sapiens_hsa005610.45969654
110Toxoplasmosis_Homo sapiens_hsa051450.45575081
111Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.45369323
112Rap1 signaling pathway_Homo sapiens_hsa040150.44452933
113Salivary secretion_Homo sapiens_hsa049700.43089020
114Protein digestion and absorption_Homo sapiens_hsa049740.42380840
115Folate biosynthesis_Homo sapiens_hsa007900.42281415
116Non-homologous end-joining_Homo sapiens_hsa034500.41268708
117Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.40840601
118Phosphatidylinositol signaling system_Homo sapiens_hsa040700.40329828
119Oocyte meiosis_Homo sapiens_hsa041140.39573411
120Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.38718192
121Oxytocin signaling pathway_Homo sapiens_hsa049210.38282361
122Dorso-ventral axis formation_Homo sapiens_hsa043200.38072521
123Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.37916988
124Selenocompound metabolism_Homo sapiens_hsa004500.37588225
125Steroid hormone biosynthesis_Homo sapiens_hsa001400.36204350
126SNARE interactions in vesicular transport_Homo sapiens_hsa041300.36038424
127Calcium signaling pathway_Homo sapiens_hsa040200.35874063
128Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.35490370
129Purine metabolism_Homo sapiens_hsa002300.35045611
130mRNA surveillance pathway_Homo sapiens_hsa030150.34874566
131Biosynthesis of amino acids_Homo sapiens_hsa012300.34855226
132Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.34778593
133Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.32267252
134Melanoma_Homo sapiens_hsa052180.31823751
135Galactose metabolism_Homo sapiens_hsa000520.31350685
136Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.30509202
137Notch signaling pathway_Homo sapiens_hsa043300.30334506
138Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.29679516
139Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.28553375
140Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.28433510
141Tuberculosis_Homo sapiens_hsa051520.28200490
142Salmonella infection_Homo sapiens_hsa051320.27795566
143Estrogen signaling pathway_Homo sapiens_hsa049150.26057773
144Circadian rhythm_Homo sapiens_hsa047100.25637912
145Inositol phosphate metabolism_Homo sapiens_hsa005620.24172274
146Endocytosis_Homo sapiens_hsa041440.24030039
147Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.24019943
148Acute myeloid leukemia_Homo sapiens_hsa052210.23508411
149Adipocytokine signaling pathway_Homo sapiens_hsa049200.22837504
150Alzheimers disease_Homo sapiens_hsa050100.20956248
151T cell receptor signaling pathway_Homo sapiens_hsa046600.20665708
152Vitamin digestion and absorption_Homo sapiens_hsa049770.20449599

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