DMP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Dentin matrix acidic phosphoprotein is an extracellular matrix protein and a member of the small integrin binding ligand N-linked glycoprotein family. This protein, which is critical for proper mineralization of bone and dentin, is present in diverse cells of bone and tooth tissues. The protein contains a large number of acidic domains, multiple phosphorylation sites, a functional arg-gly-asp cell attachment sequence, and a DNA binding domain. In undifferentiated osteoblasts it is primarily a nuclear protein that regulates the expression of osteoblast-specific genes. During osteoblast maturation the protein becomes phosphorylated and is exported to the extracellular matrix, where it orchestrates mineralized matrix formation. Mutations in the gene are known to cause autosomal recessive hypophosphatemia, a disease that manifests as rickets and osteomalacia. The gene structure is conserved in mammals. Two transcript variants encoding different isoforms have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein heterotrimerization (GO:0070208)9.25078254
2cell aggregation (GO:0098743)8.94611186
3cartilage condensation (GO:0001502)8.94611186
4tooth mineralization (GO:0034505)8.64387508
5response to phenylpropanoid (GO:0080184)8.56989270
6* biomineral tissue development (GO:0031214)8.53656158
7response to vitamin D (GO:0033280)8.42304329
8replacement ossification (GO:0036075)7.66790393
9endochondral ossification (GO:0001958)7.66790393
10positive regulation of epidermal cell differentiation (GO:0045606)7.62382643
11negative regulation of biomineral tissue development (GO:0070168)7.29589190
12keratan sulfate biosynthetic process (GO:0018146)7.12540930
13thrombin receptor signaling pathway (GO:0070493)7.09624309
14bone mineralization (GO:0030282)6.94740926
15collagen fibril organization (GO:0030199)6.80525492
16osteoblast development (GO:0002076)6.72311526
17negative regulation of bone mineralization (GO:0030502)6.66261261
18decidualization (GO:0046697)6.43380777
19skin morphogenesis (GO:0043589)6.41458095
20regulation of bone remodeling (GO:0046850)6.34526872
21keratan sulfate metabolic process (GO:0042339)6.20063787
22cellular response to nutrient (GO:0031670)6.19430335
23positive regulation of receptor internalization (GO:0002092)6.03195911
24bone trabecula formation (GO:0060346)5.91066361
25regulation of bone mineralization (GO:0030500)5.69510194
26collagen catabolic process (GO:0030574)5.54948351
27regulation of biomineral tissue development (GO:0070167)5.51636126
28collagen metabolic process (GO:0032963)5.33218606
29regulation of alkaline phosphatase activity (GO:0010692)5.20048549
30negative regulation of BMP signaling pathway (GO:0030514)5.08928828
31multicellular organismal catabolic process (GO:0044243)5.08350283
32multicellular organismal macromolecule metabolic process (GO:0044259)5.00282169
33positive regulation of epidermis development (GO:0045684)5.00063453
34regulation of extracellular matrix disassembly (GO:0010715)4.98964604
35phosphate ion transmembrane transport (GO:0035435)4.85823445
36sulfur compound catabolic process (GO:0044273)4.76283855
37sequestering of extracellular ligand from receptor (GO:0035581)4.75213785
38keratan sulfate catabolic process (GO:0042340)4.72667123
39multicellular organismal metabolic process (GO:0044236)4.69953758
40mesenchymal-epithelial cell signaling (GO:0060638)4.62459803
41osteoblast differentiation (GO:0001649)4.57216853
42regulation of tissue remodeling (GO:0034103)4.41791228
43C4-dicarboxylate transport (GO:0015740)4.34372954
44chondrocyte proliferation (GO:0035988)4.32900179
45regulation of G0 to G1 transition (GO:0070316)4.30550103
46regulation of bone resorption (GO:0045124)4.18723179
47* ossification (GO:0001503)4.16379617
48chondrocyte development (GO:0002063)4.16336008
49regulation of receptor internalization (GO:0002090)4.16149974
50neuron projection extension involved in neuron projection guidance (GO:1902284)4.13732177
51axon extension involved in axon guidance (GO:0048846)4.13732177
52import into cell (GO:0098657)4.04751191
53phosphate ion transport (GO:0006817)4.03391566
54bone morphogenesis (GO:0060349)3.98350998
55cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.97691558
56embryonic viscerocranium morphogenesis (GO:0048703)3.95866818
57extracellular matrix disassembly (GO:0022617)3.92047236
58bone development (GO:0060348)3.88286556
59lymphangiogenesis (GO:0001946)3.87210935
60positive regulation of collagen biosynthetic process (GO:0032967)3.83227891
61glycosaminoglycan catabolic process (GO:0006027)3.82798079
62response to testosterone (GO:0033574)3.80544542
63substrate-dependent cell migration (GO:0006929)3.73033095
64virion attachment to host cell (GO:0019062)3.71788409
65adhesion of symbiont to host cell (GO:0044650)3.71788409
66skeletal system development (GO:0001501)3.71447615
67response to parathyroid hormone (GO:0071107)3.69925569
68positive regulation of collagen metabolic process (GO:0010714)3.63175527
69peptidyl-proline hydroxylation (GO:0019511)3.59661548
70regulation of epidermal cell differentiation (GO:0045604)3.52325119
71anion homeostasis (GO:0055081)3.46688312
72aminoglycan catabolic process (GO:0006026)3.43653532
73endodermal cell differentiation (GO:0035987)3.38753711
74negative regulation of glycogen biosynthetic process (GO:0045719)3.37310012
75tissue remodeling (GO:0048771)3.36162409
76negative regulation of canonical Wnt signaling pathway (GO:0090090)3.35538497
77platelet dense granule organization (GO:0060155)3.35282896
78negative regulation of JNK cascade (GO:0046329)3.33726454
79regulation of BMP signaling pathway (GO:0030510)3.31994122
80positive regulation of cardiac muscle cell differentiation (GO:2000727)3.27624671
81iron ion import (GO:0097286)3.26917704
82regulation of sarcomere organization (GO:0060297)3.24258099
83peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.17485695
84positive regulation of Rho protein signal transduction (GO:0035025)3.16832224
85protein trimerization (GO:0070206)3.16340709
86regulation of collagen biosynthetic process (GO:0032965)3.14366134
87dermatan sulfate biosynthetic process (GO:0030208)3.13481446
88adhesion of symbiont to host (GO:0044406)3.10222393
89hematopoietic stem cell differentiation (GO:0060218)3.09407210
90vocalization behavior (GO:0071625)3.06458278
91positive regulation of receptor-mediated endocytosis (GO:0048260)3.06133468
92anterior/posterior axis specification, embryo (GO:0008595)3.05591948
93* extracellular matrix organization (GO:0030198)3.01053183
94* extracellular structure organization (GO:0043062)2.99851506
95mitotic cell cycle arrest (GO:0071850)2.99444904
96cellular response to amino acid stimulus (GO:0071230)2.98799817
97positive regulation of muscle hypertrophy (GO:0014742)2.98353501
98positive regulation of cardiac muscle hypertrophy (GO:0010613)2.98353501
99cartilage development (GO:0051216)2.98168857
100negative regulation of stress-activated protein kinase signaling cascade (GO:0070303)2.97745644
101negative regulation of stress-activated MAPK cascade (GO:0032873)2.97745644
102vasculature development (GO:0001944)2.95805752
103response to zinc ion (GO:0010043)2.95629788
104regulation of ossification (GO:0030278)2.93063285
105regulation of transforming growth factor beta2 production (GO:0032909)2.90959558
106dermatan sulfate metabolic process (GO:0030205)2.87474372
107regulation of tight junction assembly (GO:2000810)2.82935678
108cell morphogenesis involved in neuron differentiation (GO:0048667)2.82927174
109regulation of collagen metabolic process (GO:0010712)2.82514150
110cartilage morphogenesis (GO:0060536)2.82097077
111negative regulation of protein autophosphorylation (GO:0031953)2.81570396
112extracellular regulation of signal transduction (GO:1900115)2.80536133
113extracellular negative regulation of signal transduction (GO:1900116)2.80536133
114positive regulation of catenin import into nucleus (GO:0035413)2.79853374
115glycosaminoglycan biosynthetic process (GO:0006024)2.75650073
116negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway (GO:2.75465707
117ganglion development (GO:0061548)2.75289725
118secondary heart field specification (GO:0003139)2.74520475
119heart field specification (GO:0003128)2.74520475
120glomerular filtration (GO:0003094)2.73312224
121epithelial cell differentiation involved in kidney development (GO:0035850)2.73103087
122craniofacial suture morphogenesis (GO:0097094)2.71969516
123aminoglycan biosynthetic process (GO:0006023)2.71853920
124germinal center formation (GO:0002467)2.71044366
125regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.68933864
126negative regulation of ossification (GO:0030279)2.68851526
127positive regulation of phosphatase activity (GO:0010922)2.68365044
128positive regulation of multicellular organismal metabolic process (GO:0044253)2.68152083
129regulation of extracellular matrix organization (GO:1903053)2.67669024
130regulation of epidermis development (GO:0045682)2.67595939
131tyrosine phosphorylation of STAT protein (GO:0007260)2.66445871
132positive regulation of protein homodimerization activity (GO:0090073)2.65263170
133bone resorption (GO:0045453)2.64028605
134protein hydroxylation (GO:0018126)2.60768023
135response to vitamin (GO:0033273)2.60106816
136positive regulation of stem cell differentiation (GO:2000738)2.59396813
137extracellular matrix assembly (GO:0085029)2.56193177
138blood vessel maturation (GO:0001955)2.52254821
139phagocytosis, recognition (GO:0006910)2.49950056
140positive regulation of extracellular matrix organization (GO:1903055)2.46551097
141chondroitin sulfate biosynthetic process (GO:0030206)2.44572064
142protein retention in ER lumen (GO:0006621)2.42235224
143negative regulation of embryonic development (GO:0045992)2.41596206
144glycoprotein catabolic process (GO:0006516)2.38213775
145camera-type eye morphogenesis (GO:0048593)2.37822580
146planar cell polarity pathway involved in neural tube closure (GO:0090179)2.36377276
147regulation of osteoclast differentiation (GO:0045670)2.35599937
148Golgi transport vesicle coating (GO:0048200)2.35114683
149COPI coating of Golgi vesicle (GO:0048205)2.35114683
150cell adhesion mediated by integrin (GO:0033627)2.33523848
151embryonic cranial skeleton morphogenesis (GO:0048701)2.32926860
152negative regulation of cell fate specification (GO:0009996)2.32034828
153positive regulation of fibroblast migration (GO:0010763)2.28486241
154response to activity (GO:0014823)2.26976958
155positive regulation of epithelial to mesenchymal transition (GO:0010718)2.25611586
156chondroitin sulfate metabolic process (GO:0030204)2.23691508
157cellular response to prostaglandin stimulus (GO:0071379)2.21297915
158regulation of glomerular filtration (GO:0003093)2.21077956
159maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.17853017
160positive regulation of glycogen biosynthetic process (GO:0045725)2.17790316
161cell-matrix adhesion (GO:0007160)2.17331765
162cellular response to vitamin D (GO:0071305)15.7753834
163response to gravity (GO:0009629)12.9787195
164trivalent inorganic anion homeostasis (GO:0072506)12.8746019
165phosphate ion homeostasis (GO:0055062)12.8746019
166cellular response to vitamin (GO:0071295)12.6298288

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human5.45148500
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.11891778
3SALL1_21062744_ChIP-ChIP_HESCs_Human3.80209977
4ZNF652_21678463_ChIP-ChIP_ZR75-1_Human3.51469886
5WT1_19549856_ChIP-ChIP_CCG9911_Human3.30228450
6PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.09671883
7SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.52442079
8GBX2_23144817_ChIP-Seq_PC3_Human2.40332014
9EED_16625203_ChIP-ChIP_MESCs_Mouse2.36404407
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.35074033
11SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.34935113
12SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.29774035
13EZH2_18974828_ChIP-Seq_MESCs_Mouse2.26235220
14RNF2_18974828_ChIP-Seq_MESCs_Mouse2.26235220
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.24767078
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.23735060
17RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.95174861
18CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.92393528
19ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.91988448
20JARID2_20064375_ChIP-Seq_MESCs_Mouse1.90707558
21SMAD_19615063_ChIP-ChIP_OVARY_Human1.90104184
22CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.89580187
23JARID2_20075857_ChIP-Seq_MESCs_Mouse1.88996704
24NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.82761494
25NRF2_20460467_ChIP-Seq_MEFs_Mouse1.82761494
26DROSHA_22980978_ChIP-Seq_HELA_Human1.80590361
27RNF2_27304074_Chip-Seq_ESCs_Mouse1.78355770
28EZH2_27304074_Chip-Seq_ESCs_Mouse1.76480968
29CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.72580631
30MTF2_20144788_ChIP-Seq_MESCs_Mouse1.72574985
31* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.71388291
32FOXO3_23340844_ChIP-Seq_DLD1_Human1.69909572
33SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.68946405
34PIAS1_25552417_ChIP-Seq_VCAP_Human1.66789589
35FOXM1_26456572_ChIP-Seq_MCF-7_Human1.63234645
36ESR1_21235772_ChIP-Seq_MCF-7_Human1.60686944
37EZH2_27294783_Chip-Seq_ESCs_Mouse1.60667657
38HTT_18923047_ChIP-ChIP_STHdh_Human1.60235956
39EZH2_27294783_Chip-Seq_NPCs_Mouse1.58158362
40TP53_18474530_ChIP-ChIP_U2OS_Human1.54943128
41PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.54815609
42* CJUN_26792858_Chip-Seq_BT549_Human1.52869349
43* RARG_19884340_ChIP-ChIP_MEFs_Mouse1.52737594
44TP63_17297297_ChIP-ChIP_HaCaT_Human1.50319588
45RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.49598965
46NR3C1_21868756_ChIP-Seq_MCF10A_Human1.49068175
47SUZ12_27294783_Chip-Seq_ESCs_Mouse1.48402021
48PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.42806553
49TP53_20018659_ChIP-ChIP_R1E_Mouse1.40624701
50EZH2_22144423_ChIP-Seq_EOC_Human1.40227718
51ZNF217_24962896_ChIP-Seq_MCF-7_Human1.35989482
52TAL1_26923725_Chip-Seq_HPCs_Mouse1.35946144
53WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.34833841
54P300_19829295_ChIP-Seq_ESCs_Human1.34584098
55MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.34499293
56CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33719570
57BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.33592985
58POU3F2_20337985_ChIP-ChIP_501MEL_Human1.32307741
59CDX2_19796622_ChIP-Seq_MESCs_Mouse1.29576994
60CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.28544976
61* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.26832057
62TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.25482363
63AR_21572438_ChIP-Seq_LNCaP_Human1.23554046
64RXR_22108803_ChIP-Seq_LS180_Human1.22870776
65CDX2_22108803_ChIP-Seq_LS180_Human1.22277483
66SMAD4_21799915_ChIP-Seq_A2780_Human1.20672357
67TP63_23658742_ChIP-Seq_EP156T_Human1.19908031
68EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.19037781
69FLI1_27457419_Chip-Seq_LIVER_Mouse1.18336358
70AR_25329375_ChIP-Seq_VCAP_Human1.18019972
71CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.16215177
72E2F1_18555785_Chip-Seq_ESCs_Mouse1.15139402
73SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.14843984
74BRD4_25478319_ChIP-Seq_HGPS_Human1.14030271
75TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.14000053
76ESR1_20079471_ChIP-ChIP_T-47D_Human1.13003467
77ELK4_26923725_Chip-Seq_MESODERM_Mouse1.12437946
78KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.12357065
79KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.12357065
80KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.12357065
81SOX2_21211035_ChIP-Seq_LN229_Gbm1.12161173
82CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.11620642
83JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.11525556
84TAF15_26573619_Chip-Seq_HEK293_Human1.11435259
85* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.10730384
86EP300_21415370_ChIP-Seq_HL-1_Mouse1.10302231
87ESR2_21235772_ChIP-Seq_MCF-7_Human1.09953797
88RING1B_27294783_Chip-Seq_NPCs_Mouse1.09411246
89IKZF1_21737484_ChIP-ChIP_HCT116_Human1.09185235
90SUZ12_18555785_Chip-Seq_ESCs_Mouse1.08801458
91STAT3_23295773_ChIP-Seq_U87_Human1.08266453
92P53_22387025_ChIP-Seq_ESCs_Mouse1.07505032
93GATA2_21666600_ChIP-Seq_HMVEC_Human1.07274828
94ER_23166858_ChIP-Seq_MCF-7_Human1.06339232
95SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.05956295
96NR3C1_23031785_ChIP-Seq_PC12_Mouse1.05847670
97TCF4_18268006_ChIP-ChIP_LS174T_Human1.05825056
98AHR_22903824_ChIP-Seq_MCF-7_Human1.05787081
99RING1B_27294783_Chip-Seq_ESCs_Mouse1.05554712
100SMAD3_21741376_ChIP-Seq_EPCs_Human1.05407475
101Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.05133119
102LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05131852
103CTBP2_25329375_ChIP-Seq_LNCAP_Human1.04097938
104TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.03896727
105AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.03017093
106TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.02473641
107IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.01798615
108RUNX_20019798_ChIP-Seq_JUKART_Human1.00782999
109KLF5_20875108_ChIP-Seq_MESCs_Mouse1.00007178
110ARNT_22903824_ChIP-Seq_MCF-7_Human0.99166157
111ZFP57_27257070_Chip-Seq_ESCs_Mouse0.98995291
112GATA1_22025678_ChIP-Seq_K562_Human0.98800549
113OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98307315
114CLOCK_20551151_ChIP-Seq_293T_Human0.97339782
115SMAD3_21741376_ChIP-Seq_HESCs_Human0.97117302
116FLI1_21867929_ChIP-Seq_TH2_Mouse0.96954445
117* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.96729698
118CMYC_18555785_Chip-Seq_ESCs_Mouse0.96664399
119SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.94843164
120RBPJ_22232070_ChIP-Seq_NCS_Mouse0.94655529
121NANOG_18555785_Chip-Seq_ESCs_Mouse0.94388278
122CBP_20019798_ChIP-Seq_JUKART_Human0.94036323
123IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.94036323
124ERG_21242973_ChIP-ChIP_JURKAT_Human0.93774980
125EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.92631571
126ESR1_15608294_ChIP-ChIP_MCF-7_Human0.90623189
127VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.90048922
128TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.89969332
129TOP2B_26459242_ChIP-Seq_MCF-7_Human0.89341034
130TP53_16413492_ChIP-PET_HCT116_Human0.88958329
131SUZ12_27294783_Chip-Seq_NPCs_Mouse0.88397500
132JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.88138263
133SMC1_22415368_ChIP-Seq_MEFs_Mouse0.87234359
134CTBP1_25329375_ChIP-Seq_LNCAP_Human0.87016681
135VDR_24787735_ChIP-Seq_THP-1_Human0.86832911
136SA1_22415368_ChIP-Seq_MEFs_Mouse0.86088373
137FUS_26573619_Chip-Seq_HEK293_Human0.85592942
138TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.85320112
139SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.83438325
140SMAD4_21741376_ChIP-Seq_EPCs_Human0.83344162
141CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.82717408

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004185_abnormal_adipocyte_glucose8.42812306
2MP0008438_abnormal_cutaneous_collagen5.67964106
3MP0005083_abnormal_biliary_tract5.57454480
4MP0005503_abnormal_tendon_morphology4.63689432
5MP0002998_abnormal_bone_remodeling4.48666228
6MP0002896_abnormal_bone_mineralization3.98114846
7MP0005275_abnormal_skin_tensile3.79552566
8MP0005666_abnormal_adipose_tissue3.51931188
9MP0006054_spinal_hemorrhage2.83019593
10MP0003279_aneurysm2.68503051
11MP0005084_abnormal_gallbladder_morpholo2.51013247
12MP0005257_abnormal_intraocular_pressure2.44214864
13MP0003718_maternal_effect2.24101854
14MP0005375_adipose_tissue_phenotype2.23345513
15MP0001533_abnormal_skeleton_physiology2.17960385
16MP0009384_cardiac_valve_regurgitation2.11408275
17* MP0002115_abnormal_skeleton_extremities2.08516018
18MP0003646_muscle_fatigue2.04066429
19MP0004019_abnormal_vitamin_homeostasis2.03621293
20* MP0003795_abnormal_bone_structure2.01794009
21MP0001542_abnormal_bone_strength10.1061111
22MP0005365_abnormal_bile_salt1.94180521
23MP0002108_abnormal_muscle_morphology1.86927996
24MP0005085_abnormal_gallbladder_physiolo1.86126853
25MP0005390_skeleton_phenotype1.81294560
26MP0009250_abnormal_appendicular_skeleto1.78510641
27MP0001664_abnormal_digestion1.77415643
28MP0010368_abnormal_lymphatic_system1.75775336
29MP0005508_abnormal_skeleton_morphology1.66297310
30MP0002295_abnormal_pulmonary_circulatio1.65762951
31MP0004272_abnormal_basement_membrane1.65460625
32MP0005623_abnormal_meninges_morphology1.59491097
33MP0003183_abnormal_peptide_metabolism1.54887914
34* MP0002113_abnormal_skeleton_development1.48523145
35MP0001958_emphysema1.46778822
36MP0009115_abnormal_fat_cell1.39963586
37* MP0000163_abnormal_cartilage_morphology1.38723047
38MP0000751_myopathy1.34528242
39MP0004859_abnormal_synaptic_plasticity1.32397954
40MP0004510_myositis1.30670086
41MP0003195_calcinosis1.26609883
42MP0001666_abnormal_nutrient_absorption1.22346830
43MP0001299_abnormal_eye_distance/1.22044037
44MP0002089_abnormal_postnatal_growth/wei1.20975836
45MP0000013_abnormal_adipose_tissue1.19910335
46MP0004134_abnormal_chest_morphology1.14608982
47MP0005023_abnormal_wound_healing1.14197144
48MP0001879_abnormal_lymphatic_vessel1.13730455
49MP0003705_abnormal_hypodermis_morpholog1.10610583
50* MP0002109_abnormal_limb_morphology1.05605761
51MP0002060_abnormal_skin_morphology0.99458488
52MP0005448_abnormal_energy_balance0.98665638
53MP0001765_abnormal_ion_homeostasis0.97770862
54MP0001243_abnormal_dermal_layer0.95068671
55MP0003566_abnormal_cell_adhesion0.91919534
56MP0002233_abnormal_nose_morphology0.90395353
57MP0005076_abnormal_cell_differentiation0.90235550
58MP0002163_abnormal_gland_morphology0.89049174
59MP0004084_abnormal_cardiac_muscle0.82388453
60MP0002282_abnormal_trachea_morphology0.80211116
61MP0005164_abnormal_response_to0.79839022
62MP0002419_abnormal_innate_immunity0.78846148
63MP0009780_abnormal_chondrocyte_physiolo0.77327454
64MP0001944_abnormal_pancreas_morphology0.75532835
65MP0001915_intracranial_hemorrhage0.67765975
66MP0001346_abnormal_lacrimal_gland0.67135664
67MP0010030_abnormal_orbit_morphology0.66378578
68MP0005464_abnormal_platelet_physiology0.65919516
69MP0003868_abnormal_feces_composition0.65179200
70* MP0002116_abnormal_craniofacial_bone0.64757113
71MP0005636_abnormal_mineral_homeostasis0.64005840
72MP0005187_abnormal_penis_morphology0.62609730
73MP0004858_abnormal_nervous_system0.61357089
74MP0002933_joint_inflammation0.61082709
75MP0001188_hyperpigmentation0.59359253
76MP0003959_abnormal_lean_body0.56892961
77MP0002168_other_aberrant_phenotype0.56261785
78MP0000604_amyloidosis0.54922991
79MP0003300_gastrointestinal_ulcer0.53673431
80MP0005171_absent_coat_pigmentation0.53272698
81MP0000049_abnormal_middle_ear0.53026649
82* MP0000432_abnormal_head_morphology0.52379185
83MP0003385_abnormal_body_wall0.48208027
84MP0003045_fibrosis0.47685076
85MP0000566_synostosis0.47049242
86MP0001849_ear_inflammation0.46774486
87MP0009278_abnormal_bone_marrow0.45955661
88MP0002932_abnormal_joint_morphology0.45910695
89MP0005386_behavior/neurological_phenoty0.45159970
90MP0004924_abnormal_behavior0.45159970
91MP0000465_gastrointestinal_hemorrhage0.44995743
92MP0003091_abnormal_cell_migration0.44963452
93MP0000762_abnormal_tongue_morphology0.43997559
94MP0000003_abnormal_adipose_tissue0.43398826
95MP0005369_muscle_phenotype0.41413613
96MP0002177_abnormal_outer_ear0.41321155
97MP0005621_abnormal_cell_physiology0.40193362
98MP0002249_abnormal_larynx_morphology0.40178402
99MP0002114_abnormal_axial_skeleton0.39877259
100* MP0003935_abnormal_craniofacial_develop0.39195101
101MP0000026_abnormal_inner_ear0.39184360
102MP0005165_increased_susceptibility_to0.38977490
103MP0005595_abnormal_vascular_smooth0.38908853
104MP0001731_abnormal_postnatal_growth0.38857556
105MP0005379_endocrine/exocrine_gland_phen0.38775649
106MP0004036_abnormal_muscle_relaxation0.38470849
107MP0000358_abnormal_cell_content/0.38033508
108MP0002693_abnormal_pancreas_physiology0.37993744
109MP0000428_abnormal_craniofacial_morphol0.37739526
110MP0003755_abnormal_palate_morphology0.36425322
111MP0002877_abnormal_melanocyte_morpholog0.36197216
112MP0001177_atelectasis0.36166433
113MP0003283_abnormal_digestive_organ0.36035850
114MP0000767_abnormal_smooth_muscle0.35664881
115MP0003890_abnormal_embryonic-extraembry0.35415814
116MP0005174_abnormal_tail_pigmentation0.34920174
117MP0002111_abnormal_tail_morphology0.34064082
118MP0003942_abnormal_urinary_system0.33055001
119MP0004133_heterotaxia0.32289966
120MP0000749_muscle_degeneration0.32189322
121MP0000371_diluted_coat_color0.31869539
122MP0001919_abnormal_reproductive_system0.31338541
123MP0000462_abnormal_digestive_system0.31236037
124MP0001348_abnormal_lacrimal_gland0.30774250
125MP0002909_abnormal_adrenal_gland0.30575653
126MP0002876_abnormal_thyroid_physiology0.30218749
127MP0003948_abnormal_gas_homeostasis0.30015395
128MP0003956_abnormal_body_size0.29690850
129MP0002452_abnormal_antigen_presenting0.28516710
130MP0003937_abnormal_limbs/digits/tail_de0.28449892
131MP0000733_abnormal_muscle_development0.28018599
132MP0005319_abnormal_enzyme/_coenzyme0.26914026
133MP0004883_abnormal_blood_vessel0.26845557
134MP0003635_abnormal_synaptic_transmissio0.26725810
135MP0005395_other_phenotype0.26673798
136MP0003941_abnormal_skin_development0.26303024
137MP0002064_seizures0.26055030
138MP0000579_abnormal_nail_morphology0.26042789
139MP0005452_abnormal_adipose_tissue0.24414300
140MP0003633_abnormal_nervous_system0.23894151
141MP0002128_abnormal_blood_circulation0.22235317
142MP0010386_abnormal_urinary_bladder0.22212313
143MP0000343_altered_response_to0.21528274
144MP0000569_abnormal_digit_pigmentation0.21473537
145MP0002332_abnormal_exercise_endurance0.20877060
146MP0001963_abnormal_hearing_physiology0.20659247

Predicted human phenotypes

RankGene SetZ-score
1Metaphyseal cupping (HP:0003021)9.21446563
2Protrusio acetabuli (HP:0003179)8.49867682
3Premature rupture of membranes (HP:0001788)6.87451884
4Facial diplegia (HP:0001349)6.78568217
5Small epiphyses (HP:0010585)6.35830169
6Biconcave vertebral bodies (HP:0004586)5.74303433
7* Hypophosphatemic rickets (HP:0004912)5.66846569
8Ulnar bowing (HP:0003031)5.56143298
9Enlarged epiphyses (HP:0010580)5.43024595
10Papilledema (HP:0001085)5.35993470
11Abnormality of dentin (HP:0010299)5.23144600
12Wormian bones (HP:0002645)4.99071045
13Neonatal short-limb short stature (HP:0008921)4.92504773
14Tibial bowing (HP:0002982)4.84626968
15Femoral bowing (HP:0002980)4.82743233
16Cupped ribs (HP:0000887)4.75236701
17Osteomalacia (HP:0002749)4.57340321
18Sudden death (HP:0001699)4.49966307
19Soft skin (HP:0000977)4.31386951
20Peritonitis (HP:0002586)4.26967918
21Atrophic scars (HP:0001075)4.24977028
22Flattened epiphyses (HP:0003071)4.21239181
23Abnormality of the vertebral endplates (HP:0005106)4.16229743
24Irregular vertebral endplates (HP:0003301)4.04670843
25Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.87698329
26Radial bowing (HP:0002986)3.83732313
27Vertebral compression fractures (HP:0002953)3.80860221
28Mild short stature (HP:0003502)3.75522380
29Osteoarthritis (HP:0002758)3.68314774
30Flared iliac wings (HP:0002869)3.67037069
31Blue sclerae (HP:0000592)3.64458389
32Breech presentation (HP:0001623)3.60194445
33Bowed forearm bones (HP:0003956)3.52497617
34Bowing of the arm (HP:0006488)3.52497617
35Elevated alkaline phosphatase (HP:0003155)3.48073135
36Coxa vara (HP:0002812)3.42624919
37Constricted visual fields (HP:0001133)3.41878961
38Aortic dissection (HP:0002647)3.38422925
39Flared metaphyses (HP:0003015)3.34809145
40Decreased skull ossification (HP:0004331)3.29428795
41Platyspondyly (HP:0000926)3.29055309
42Broad metatarsal (HP:0001783)3.28182720
43Metaphyseal irregularity (HP:0003025)3.21974734
44Genu recurvatum (HP:0002816)3.17066679
45Nonimmune hydrops fetalis (HP:0001790)3.12667464
46Bladder diverticulum (HP:0000015)3.04514137
47Follicular hyperkeratosis (HP:0007502)3.03773824
48Abnormality of the costochondral junction (HP:0000919)2.97094210
49Morphological abnormality of the middle ear (HP:0008609)2.96057254
50Metaphyseal dysplasia (HP:0100255)2.92258385
51Abnormality of skull ossification (HP:0002703)2.91062351
52Craniofacial hyperostosis (HP:0004493)2.88195458
53Broad ribs (HP:0000885)2.83001882
54Fragile skin (HP:0001030)2.82665881
55Abnormality of calcium-phosphate metabolism (HP:0100530)2.82189718
56Cervical subluxation (HP:0003308)2.79999251
57Abnormal delivery (HP:0001787)2.77932002
58Abnormality of Sharpey fibers (HP:0100685)2.74042767
59Infantile muscular hypotonia (HP:0008947)2.73338699
60Short middle phalanx of finger (HP:0005819)2.73049258
61Spinal cord compression (HP:0002176)2.70543581
62Bell-shaped thorax (HP:0001591)2.66862136
63Shallow orbits (HP:0000586)2.64773851
64Vertebral clefting (HP:0008428)2.64694138
65Widely patent fontanelles and sutures (HP:0004492)2.63437068
66Hyperextensible skin (HP:0000974)2.54288367
67Genu varum (HP:0002970)2.54158536
68Ankle contracture (HP:0006466)2.50490819
69Rhizomelia (HP:0008905)2.43771551
70Absent frontal sinuses (HP:0002688)2.42141142
71Wide cranial sutures (HP:0010537)2.39545636
72Arthropathy (HP:0003040)2.39449892
73Abnormality of the epiphysis of the femoral head (HP:0010574)2.39184688
74Increased density of long bones (HP:0006392)2.39158777
75Epiphyseal dysplasia (HP:0002656)2.37322085
76Cranial hyperostosis (HP:0004437)2.33420354
77Progressive visual loss (HP:0000529)2.33298109
78Limited elbow extension (HP:0001377)2.32342607
79Abnormality of the acetabulum (HP:0003170)2.32187639
80* Rickets (HP:0002748)2.31854773
81Overgrowth (HP:0001548)2.30535621
82Abnormality of the ischium (HP:0003174)2.26689859
83Waddling gait (HP:0002515)2.24305263
84Hypoplastic ischia (HP:0003175)2.23756287
85Wide anterior fontanel (HP:0000260)2.20401918
86Abnormality involving the epiphyses of the lower limbs (HP:0006500)2.20216999
87Abnormality of femoral epiphyses (HP:0006499)2.20216999
88Choanal stenosis (HP:0000452)2.19636915
89Persistence of primary teeth (HP:0006335)2.19312834
90Abnormality of the femoral head (HP:0003368)2.18584620
91Mitral valve prolapse (HP:0001634)2.18533432
92Abnormal vertebral ossification (HP:0100569)2.18038524
93Osteopenia (HP:0000938)2.13300588
94Aplasia/Hypoplasia of the middle phalanges of the hand (HP:0009843)2.10612291
95Spondylolisthesis (HP:0003302)2.03948713
96Abnormal cortical bone morphology (HP:0003103)2.03715969
97* Hypophosphatemia (HP:0002148)1.99661896
98Bowel diverticulosis (HP:0005222)1.98326410
99Abnormality of alkaline phosphatase activity (HP:0004379)1.97154299
100Spinal canal stenosis (HP:0003416)1.96847457
101Premature loss of primary teeth (HP:0006323)1.95398181
102Narrow nasal bridge (HP:0000446)1.94357068
103Prominent supraorbital ridges (HP:0000336)1.93839336
104Deviation of the hallux (HP:0010051)1.93342269
105Dilatation of the ascending aorta (HP:0005111)1.92265902
106Abnormal enzyme/coenzyme activity (HP:0012379)1.89872483
107Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.88728535
108Midface retrusion (HP:0011800)1.88646649
109Esotropia (HP:0000565)1.87399842
110Osteolytic defects of the phalanges of the hand (HP:0009771)1.87011336
111Osteolytic defects of the hand bones (HP:0009699)1.87011336
112Abnormality of the middle phalanges of the hand (HP:0009833)1.85424187
113Stillbirth (HP:0003826)1.84006320
114Joint laxity (HP:0001388)1.83578698
115Hallux valgus (HP:0001822)1.83546098
116Abnormality of the peritoneum (HP:0002585)1.82206579
117Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.82103565
118Abnormality of primary teeth (HP:0006481)1.81559804
119Broad long bones (HP:0005622)1.79746407
120Abnormality of the frontal sinuses (HP:0002687)1.78410351
121Bone pain (HP:0002653)1.78233989
122Arterial tortuosity (HP:0005116)1.76441275
123Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.76290618
124Pathologic fracture (HP:0002756)1.76274641
125Abnormal tarsal ossification (HP:0008369)1.75823059
126Carpal bone hypoplasia (HP:0001498)1.71970099
127Abnormal cartilage morphology (HP:0002763)1.63800574
128Vascular tortuosity (HP:0004948)1.54992657
129Hypercalcemia (HP:0003072)1.50188192
130Broad phalanges of the hand (HP:0009768)1.50083681
131Abnormality of intracranial pressure (HP:0012640)1.49634039
132Increased intracranial pressure (HP:0002516)1.49634039
133Abnormal urine phosphate concentration (HP:0012599)1.48849882
134Mixed hearing impairment (HP:0000410)1.48190461
135Atresia of the external auditory canal (HP:0000413)1.42349569
136Cardiovascular calcification (HP:0011915)1.42103505
137Broad phalanx (HP:0006009)1.42051141
138Broad finger (HP:0001500)1.40545612
139Vascular calcification (HP:0004934)1.34645212
140Delayed epiphyseal ossification (HP:0002663)1.31058005
141Beaking of vertebral bodies (HP:0004568)1.25258676
142Chondrocalcinosis (HP:0000934)1.23868332
143Syringomyelia (HP:0003396)1.19578830
144Spinal cord lesions (HP:0100561)1.19578830
145Short distal phalanx of finger (HP:0009882)1.17647248
146Abnormality of the fibula (HP:0002991)1.17343472
147Abnormality of the intervertebral disk (HP:0005108)1.14810934
148Delayed closure of the anterior fontanelle (HP:0001476)1.14317716
149Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.13292151
150Dental malocclusion (HP:0000689)1.12715825
151Aortic aneurysm (HP:0004942)1.09457254
152Mandibular prognathia (HP:0000303)1.08298271
153Renal tubular dysfunction (HP:0000124)1.06581707
154Short middle phalanx of the 5th finger (HP:0004220)1.04921704
155Hypoplasia of the odontoid process (HP:0003311)1.03728419
156Limited hip movement (HP:0008800)0.99215504
157Ovoid vertebral bodies (HP:0003300)0.97354841

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK14.97087153
2EPHA34.33191926
3MST1R3.71640977
4ARAF3.52150302
5NLK3.22338100
6PNCK3.16205227
7FGFR22.82942712
8CASK2.38982718
9LATS12.27540619
10PDGFRA2.22019709
11CAMK1G2.17419593
12NTRK32.09289876
13MST42.04135591
14CCNB12.02452819
15PLK22.01143155
16DDR210.0701398
17TRIB31.80616464
18NEK91.50958322
19TAF11.48509451
20CSF1R1.46806562
21SGK21.39383403
22MAP3K41.39129215
23FGFR11.38113231
24BRAF1.38070769
25DMPK1.37930709
26MAP3K91.37812862
27STK241.37573943
28TEC1.34359909
29TRPM71.32093346
30EPHB21.31931861
31AKT31.31188191
32PIK3CA1.29522955
33MAP3K131.28444740
34EPHA41.28303292
35JAK11.26102029
36RIPK11.25117547
37NTRK11.23088499
38MAPK121.19673219
39FER1.14937731
40PRPF4B1.14701844
41TGFBR21.07771817
42EIF2AK11.07339604
43FRK1.05380132
44BMX1.03917043
45CDK81.03229879
46PRKG21.02276655
47MOS1.01914738
48PRKCE0.99831558
49ERBB40.99764091
50MAPK70.99250420
51PKN10.99074692
52PAK30.97939537
53ERBB30.97232680
54PRKCG0.97128380
55DAPK20.96894805
56PIK3CG0.94010131
57MAP3K20.93945378
58ROCK10.91990700
59EIF2AK20.91604761
60FGFR30.88595864
61RAF10.83259950
62MELK0.83059499
63LATS20.82274335
64PDGFRB0.81133561
65TTN0.80374442
66SGK30.80329362
67ROCK20.79076820
68MAPKAPK50.78525354
69PDK20.77567638
70EPHA20.76778464
71MAP3K100.73116512
72MET0.72418470
73TAOK30.68552142
74STK38L0.68199006
75ADRBK10.66959585
76MYLK0.66355234
77EIF2AK30.65398618
78SGK2230.64694007
79SGK4940.64694007
80MAPK100.63564499
81IGF1R0.63076840
82SIK20.62055755
83TYRO30.62042305
84CSNK1A1L0.60651920
85PBK0.60026190
86PAK60.59606826
87JAK30.57985353
88NTRK20.57536822
89RET0.57283538
90CAMKK10.56951691
91FGFR40.55799823
92KSR20.55753809
93PHKG20.55623538
94PHKG10.55623538
95STK100.53194126
96PIM20.52393531
97INSR0.51179395
98LRRK20.49209822
99DYRK1B0.48189422
100PAK20.47863782
101TNIK0.47709361
102CAMK1D0.46879570
103PTK60.45793401
104CAMKK20.45451447
105NEK60.44941820
106FGR0.44171714
107PRKCH0.43906610
108FLT30.43030875
109SRC0.42885458
110IKBKB0.42744438
111STK390.41864903
112CSK0.40894197
113PTK2B0.40183504
114CDK60.40031534
115CHUK0.39371127
116CDK50.39230891
117PKN20.38580207
118FYN0.38496219
119STK380.37679600
120PTK20.36376247
121KSR10.36312652
122STK30.35151301
123CAMK10.34929702
124KIT0.34285817
125MAPK140.33934786
126WNK10.33520003
127PRKAA20.32425703
128ERN10.32280216
129MUSK0.31904381
130DAPK30.31595951
131MAP2K70.31289915
132LMTK20.31204706
133EPHB10.31158243
134PDK10.31056384
135TIE10.30911107
136MAPK30.30730627
137MAPK40.28659560
138PDPK10.26449377
139NME20.26049071
140SCYL20.25341182
141MKNK10.24418692
142WNK40.24231190
143SYK0.24076426
144PAK40.24030983
145PRKCB0.23798951
146BLK0.23479180
147MAP2K10.22736513
148NUAK10.22520090
149PRKCA0.22235767
150PRKD10.21754882
151CDK90.21753433
152TYK20.21686335
153CSNK1G10.21272918
154GSK3A0.21202276
155PRKG10.20590574
156MAPK130.20294276
157PRKCQ0.19661471

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045126.23063855
2Protein digestion and absorption_Homo sapiens_hsa049743.96164933
3Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005323.40245118
4Folate biosynthesis_Homo sapiens_hsa007903.27081062
5Focal adhesion_Homo sapiens_hsa045103.10515970
6Collecting duct acid secretion_Homo sapiens_hsa049662.91783426
7Complement and coagulation cascades_Homo sapiens_hsa046102.15434100
8Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.05332293
9PI3K-Akt signaling pathway_Homo sapiens_hsa041511.94421397
10Malaria_Homo sapiens_hsa051441.72252315
11Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.61129738
12AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.52299008
13Wnt signaling pathway_Homo sapiens_hsa043101.48168393
14Dilated cardiomyopathy_Homo sapiens_hsa054141.46698971
15Colorectal cancer_Homo sapiens_hsa052101.38526654
16Amoebiasis_Homo sapiens_hsa051461.35936903
17Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.35246407
18Proteoglycans in cancer_Homo sapiens_hsa052051.34026570
19Phagosome_Homo sapiens_hsa041451.28791547
20Axon guidance_Homo sapiens_hsa043601.26678498
21Cocaine addiction_Homo sapiens_hsa050301.26086828
22Prolactin signaling pathway_Homo sapiens_hsa049171.23730430
23Melanoma_Homo sapiens_hsa052181.23281806
24Olfactory transduction_Homo sapiens_hsa047401.20945398
25Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.20085798
26Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.19328363
27Rheumatoid arthritis_Homo sapiens_hsa053231.19322762
28Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.17944625
29MicroRNAs in cancer_Homo sapiens_hsa052061.17780477
30Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.16694377
31Melanogenesis_Homo sapiens_hsa049161.16604429
32Bladder cancer_Homo sapiens_hsa052191.12402377
33Basal cell carcinoma_Homo sapiens_hsa052171.10983660
34Thyroid hormone synthesis_Homo sapiens_hsa049181.09434161
35Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.06411553
36Vibrio cholerae infection_Homo sapiens_hsa051101.06198021
37Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.03833493
38Glioma_Homo sapiens_hsa052141.03219308
39Nicotine addiction_Homo sapiens_hsa050331.02583192
40TGF-beta signaling pathway_Homo sapiens_hsa043501.00441807
41Renal cell carcinoma_Homo sapiens_hsa052111.00392564
42Pancreatic secretion_Homo sapiens_hsa049721.00216445
43Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.99053007
44Amphetamine addiction_Homo sapiens_hsa050310.97995598
45Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.97049315
46Dorso-ventral axis formation_Homo sapiens_hsa043200.96459962
47Estrogen signaling pathway_Homo sapiens_hsa049150.96352507
48Chemokine signaling pathway_Homo sapiens_hsa040620.94075137
49Prostate cancer_Homo sapiens_hsa052150.92508455
50Lysosome_Homo sapiens_hsa041420.92413713
51Platelet activation_Homo sapiens_hsa046110.91773411
52Insulin secretion_Homo sapiens_hsa049110.91136992
53Glutamatergic synapse_Homo sapiens_hsa047240.90854011
54Aldosterone synthesis and secretion_Homo sapiens_hsa049250.88655249
55Hedgehog signaling pathway_Homo sapiens_hsa043400.88451288
56Cholinergic synapse_Homo sapiens_hsa047250.88380012
57cGMP-PKG signaling pathway_Homo sapiens_hsa040220.86947919
58Circadian entrainment_Homo sapiens_hsa047130.83445160
59Thyroid cancer_Homo sapiens_hsa052160.83093055
60Gap junction_Homo sapiens_hsa045400.82946766
61Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.82533823
62Hippo signaling pathway_Homo sapiens_hsa043900.81530676
63Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.81239690
64Synaptic vesicle cycle_Homo sapiens_hsa047210.80954811
65Salivary secretion_Homo sapiens_hsa049700.79294264
66Rap1 signaling pathway_Homo sapiens_hsa040150.78731700
67Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.78580903
68Regulation of actin cytoskeleton_Homo sapiens_hsa048100.76755848
69Adherens junction_Homo sapiens_hsa045200.76561342
70GABAergic synapse_Homo sapiens_hsa047270.76548152
71Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.73646586
72GnRH signaling pathway_Homo sapiens_hsa049120.72373442
73Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.72173368
74Gastric acid secretion_Homo sapiens_hsa049710.71324354
75Long-term depression_Homo sapiens_hsa047300.69985450
76Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.66264346
77TNF signaling pathway_Homo sapiens_hsa046680.65261170
78Sulfur metabolism_Homo sapiens_hsa009200.64934700
79Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.64879932
80Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.64661417
81beta-Alanine metabolism_Homo sapiens_hsa004100.64051280
82Circadian rhythm_Homo sapiens_hsa047100.63171828
83Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.62449534
84Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.61677986
85Phospholipase D signaling pathway_Homo sapiens_hsa040720.58424018
86Dopaminergic synapse_Homo sapiens_hsa047280.57991704
87Ras signaling pathway_Homo sapiens_hsa040140.56759882
88Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.56404121
89Renin secretion_Homo sapiens_hsa049240.55927084
90Morphine addiction_Homo sapiens_hsa050320.55850648
91Neurotrophin signaling pathway_Homo sapiens_hsa047220.55275139
92Oxytocin signaling pathway_Homo sapiens_hsa049210.55274313
93Leukocyte transendothelial migration_Homo sapiens_hsa046700.55073248
94Non-small cell lung cancer_Homo sapiens_hsa052230.53613812
95Thyroid hormone signaling pathway_Homo sapiens_hsa049190.52973747
96Long-term potentiation_Homo sapiens_hsa047200.52524378
97Chronic myeloid leukemia_Homo sapiens_hsa052200.50606414
98Osteoclast differentiation_Homo sapiens_hsa043800.50440351
99Other glycan degradation_Homo sapiens_hsa005110.49701205
100Calcium signaling pathway_Homo sapiens_hsa040200.48906135
101cAMP signaling pathway_Homo sapiens_hsa040240.48793407
102Hematopoietic cell lineage_Homo sapiens_hsa046400.48726429
103Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.48656543
104Nitrogen metabolism_Homo sapiens_hsa009100.48222012
105Endometrial cancer_Homo sapiens_hsa052130.46738485
106Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.46346698
107Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.45860840
108Arachidonic acid metabolism_Homo sapiens_hsa005900.45005117
109Hepatitis B_Homo sapiens_hsa051610.44782548
110Small cell lung cancer_Homo sapiens_hsa052220.43145302
111Pancreatic cancer_Homo sapiens_hsa052120.42768961
112Insulin resistance_Homo sapiens_hsa049310.42547078
113Transcriptional misregulation in cancer_Homo sapiens_hsa052020.41687901
114FoxO signaling pathway_Homo sapiens_hsa040680.41431823
115Arginine and proline metabolism_Homo sapiens_hsa003300.39984693
116Ovarian steroidogenesis_Homo sapiens_hsa049130.39923258
117Pathways in cancer_Homo sapiens_hsa052000.39513961
118Glycosaminoglycan degradation_Homo sapiens_hsa005310.39473655
119Viral myocarditis_Homo sapiens_hsa054160.37716435
120Choline metabolism in cancer_Homo sapiens_hsa052310.36733140
121Vascular smooth muscle contraction_Homo sapiens_hsa042700.36087207
122Staphylococcus aureus infection_Homo sapiens_hsa051500.35893980
123Toll-like receptor signaling pathway_Homo sapiens_hsa046200.33562718
124Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.32802901
125ErbB signaling pathway_Homo sapiens_hsa040120.32702111
126Tuberculosis_Homo sapiens_hsa051520.32543369
127Longevity regulating pathway - mammal_Homo sapiens_hsa042110.31757912
128Starch and sucrose metabolism_Homo sapiens_hsa005000.30699336
129Endocytosis_Homo sapiens_hsa041440.30316797
130Sphingolipid metabolism_Homo sapiens_hsa006000.29598515
131Serotonergic synapse_Homo sapiens_hsa047260.29484812
132MAPK signaling pathway_Homo sapiens_hsa040100.28538133
133Acute myeloid leukemia_Homo sapiens_hsa052210.26416717
134Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.22984578

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