DMPK

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a serine-threonine kinase that is closely related to other kinases that interact with members of the Rho family of small GTPases. Substrates for this enzyme include myogenin, the beta-subunit of the L-type calcium channels, and phospholemman. The 3' untranslated region of this gene contains 5-38 copies of a CTG trinucleotide repeat. Expansion of this unstable motif to 50-5,000 copies causes myotonic dystrophy type I, which increases in severity with increasing repeat element copy number. Repeat expansion is associated with condensation of local chromatin structure that disrupts the expression of genes in this region. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sarcomere organization (GO:0045214)8.31544425
2cardiac myofibril assembly (GO:0055003)7.21241599
3muscle filament sliding (GO:0030049)7.09333308
4actin-myosin filament sliding (GO:0033275)7.09333308
5myofibril assembly (GO:0030239)6.71548341
6plasma membrane repair (GO:0001778)6.65376326
7negative regulation of potassium ion transmembrane transporter activity (GO:1901017)6.60758659
8positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)6.13607621
9negative regulation of potassium ion transmembrane transport (GO:1901380)6.00398036
10actin-mediated cell contraction (GO:0070252)5.91181151
11cardiac muscle contraction (GO:0060048)5.58319664
12cardiac muscle cell development (GO:0055013)5.52834159
13regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)5.47566718
14regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO5.47312511
15actomyosin structure organization (GO:0031032)5.38440728
16cardiac cell development (GO:0055006)5.20175124
17carnitine shuttle (GO:0006853)5.18413282
18tricarboxylic acid cycle (GO:0006099)5.13890227
19bundle of His cell to Purkinje myocyte communication (GO:0086069)5.07559156
20sarcoplasmic reticulum calcium ion transport (GO:0070296)5.01713141
21ventricular cardiac muscle cell action potential (GO:0086005)4.95204415
22regulation of actin filament-based movement (GO:1903115)4.90801261
23regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.83362669
24striated muscle contraction (GO:0006941)4.82693174
25regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)4.75484128
26regulation of relaxation of muscle (GO:1901077)4.73292937
27cardiac muscle tissue morphogenesis (GO:0055008)4.61243581
28fatty acid transmembrane transport (GO:1902001)4.60149334
29actin filament-based movement (GO:0030048)4.57322738
30adult heart development (GO:0007512)4.56093853
31regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.54861452
32* regulation of skeletal muscle contraction (GO:0014819)4.53839363
33cardiac muscle hypertrophy (GO:0003300)4.52416073
34adenosine receptor signaling pathway (GO:0001973)4.39992815
35ventricular cardiac muscle tissue morphogenesis (GO:0055010)4.36819844
36striated muscle hypertrophy (GO:0014897)4.34400032
37muscle tissue morphogenesis (GO:0060415)4.32676096
38heart trabecula formation (GO:0060347)4.31207936
39regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.28914709
40response to stimulus involved in regulation of muscle adaptation (GO:0014874)4.24477030
41regulation of sarcomere organization (GO:0060297)4.20563867
42skeletal muscle contraction (GO:0003009)4.18007141
43regulation of cell communication by electrical coupling (GO:0010649)4.13508271
44positive regulation of protein kinase C signaling (GO:0090037)4.11850084
45creatine metabolic process (GO:0006600)4.10821303
46semaphorin-plexin signaling pathway (GO:0071526)4.08910512
47peptidyl-glutamic acid carboxylation (GO:0017187)4.00046217
48protein carboxylation (GO:0018214)4.00046217
49* regulation of striated muscle contraction (GO:0006942)3.95654350
50cell communication involved in cardiac conduction (GO:0086065)3.92441370
51cellular response to ATP (GO:0071318)3.89613803
52regulation of sequestering of triglyceride (GO:0010889)3.85536221
53carnitine transmembrane transport (GO:1902603)3.85520539
54regulation of membrane repolarization (GO:0060306)3.84655380
55regulation of acyl-CoA biosynthetic process (GO:0050812)3.83896006
56planar cell polarity pathway involved in neural tube closure (GO:0090179)3.83761526
57muscle hypertrophy (GO:0014896)3.81757228
58cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.80225280
59atrioventricular valve morphogenesis (GO:0003181)3.73768879
60regulation of the force of heart contraction (GO:0002026)3.73450538
61muscle contraction (GO:0006936)3.71626602
622-oxoglutarate metabolic process (GO:0006103)3.66706861
63response to inactivity (GO:0014854)3.56645613
64GDP-mannose metabolic process (GO:0019673)3.56468601
65positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.54358884
66carnitine transport (GO:0015879)3.52127976
67amino-acid betaine transport (GO:0015838)3.52127976
68negative regulation of cell aging (GO:0090344)3.51163300
69striated muscle cell development (GO:0055002)3.49900012
70regulation of cofactor metabolic process (GO:0051193)3.48372621
71regulation of coenzyme metabolic process (GO:0051196)3.48372621
72regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.46147254
73muscle system process (GO:0003012)3.45600545
74heart process (GO:0003015)3.43971186
75heart contraction (GO:0060047)3.43971186
76regulation of fatty acid oxidation (GO:0046320)3.40826446
77mannose metabolic process (GO:0006013)3.38086274
78urinary tract smooth muscle contraction (GO:0014848)3.37941489
79regulation of cardiac muscle contraction (GO:0055117)3.36205755
80NADH metabolic process (GO:0006734)3.35207779
81cardiac muscle cell action potential involved in contraction (GO:0086002)3.33893532
82cardiac muscle hypertrophy in response to stress (GO:0014898)3.33278978
83muscle hypertrophy in response to stress (GO:0003299)3.33278978
84cardiac muscle adaptation (GO:0014887)3.33278978
85cardiac muscle cell action potential (GO:0086001)3.33190430
86striated muscle adaptation (GO:0014888)3.32177406
87skeletal muscle fiber development (GO:0048741)3.31643523
88regulation of cytokine production involved in inflammatory response (GO:1900015)3.31487298
89regulation of cardioblast differentiation (GO:0051890)3.26946111
90cell communication by electrical coupling (GO:0010644)3.26444591
91skeletal muscle adaptation (GO:0043501)3.25855475
92regulation of cardiac muscle cell contraction (GO:0086004)3.25763595
93regulation of heart rate (GO:0002027)3.25651719
94negative regulation of potassium ion transport (GO:0043267)3.24587766
95fatty acid beta-oxidation (GO:0006635)3.24389905
96regulation of ATP catabolic process (GO:1903289)3.21484871
97regulation of ATPase activity (GO:0043462)3.21484871
98cell-substrate adherens junction assembly (GO:0007045)3.21389046
99focal adhesion assembly (GO:0048041)3.21389046
100striated muscle atrophy (GO:0014891)3.18960190
101protein heterotrimerization (GO:0070208)3.16319712
102positive regulation of myotube differentiation (GO:0010831)3.13932598
103negative regulation of protein localization to cell surface (GO:2000009)3.12424411
104oxygen transport (GO:0015671)3.12212945
105basement membrane organization (GO:0071711)3.11783452
106regulation of p38MAPK cascade (GO:1900744)3.10599242
107positive regulation of cation channel activity (GO:2001259)3.09145871
108relaxation of cardiac muscle (GO:0055119)3.08858770
109muscle fiber development (GO:0048747)3.08120657
110adherens junction assembly (GO:0034333)3.05201181
111synaptic vesicle docking involved in exocytosis (GO:0016081)3.04215080
112muscle cell development (GO:0055001)3.01872669
113cell migration in hindbrain (GO:0021535)3.01228641
114* regulation of heart contraction (GO:0008016)3.00711883
115regulation of calcium ion transmembrane transporter activity (GO:1901019)3.00492263
116regulation of calcium ion transmembrane transport (GO:1903169)3.00492263
117DNA strand renaturation (GO:0000733)3.00063301
118positive regulation of heart contraction (GO:0045823)2.99431576
119negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.98221121
120trabecula formation (GO:0060343)2.94421658
121cardiac conduction (GO:0061337)2.92443381
122aspartate family amino acid catabolic process (GO:0009068)2.91543680
123lysine metabolic process (GO:0006553)2.88505610
124lens fiber cell differentiation (GO:0070306)2.84285967
125type B pancreatic cell proliferation (GO:0044342)2.82825685
126UV protection (GO:0009650)2.82478323
127myotube cell development (GO:0014904)2.82263967
128cell migration involved in heart development (GO:0060973)2.76987760
129endocytic recycling (GO:0032456)2.74314162
130negative regulation of catenin import into nucleus (GO:0035414)2.71131164
131neuromuscular junction development (GO:0007528)2.70498465
132extracellular matrix assembly (GO:0085029)2.68067231
133regulation of phospholipid biosynthetic process (GO:0071071)2.66032334
134negative regulation of cell size (GO:0045792)2.65574167
135muscle cell fate commitment (GO:0042693)2.64024681
136muscle organ development (GO:0007517)2.61034902
137cell-substrate junction assembly (GO:0007044)2.59611855
138bone trabecula formation (GO:0060346)2.59444541
139neuromuscular synaptic transmission (GO:0007274)2.57364609
140muscle structure development (GO:0061061)2.55247572
141skeletal muscle tissue development (GO:0007519)2.54578645
142activation of protein kinase A activity (GO:0034199)2.52699197
143convergent extension (GO:0060026)2.50644706
144cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.49930927
145response to muscle activity (GO:0014850)2.49145745
146endothelial cell chemotaxis (GO:0035767)2.47223846
147neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.47032006
148mitotic cell cycle arrest (GO:0071850)2.45558499
149mitochondrial genome maintenance (GO:0000002)2.45492538
150phosphate ion transmembrane transport (GO:0035435)2.45299456

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.90446826
2EP300_21415370_ChIP-Seq_HL-1_Mouse3.44716927
3TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.27846363
4TBX20_22328084_ChIP-Seq_HEART_Mouse3.13939536
5TBX20_22080862_ChIP-Seq_HEART_Mouse3.13939536
6* RARG_19884340_ChIP-ChIP_MEFs_Mouse3.10752626
7EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse3.07241923
8VDR_21846776_ChIP-Seq_THP-1_Human2.90961238
9ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.76149006
10ERG_21242973_ChIP-ChIP_JURKAT_Human2.64286685
11ESR1_20079471_ChIP-ChIP_T-47D_Human2.58550472
12ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.50824954
13ZNF263_19887448_ChIP-Seq_K562_Human2.45499200
14TRIM28_21343339_ChIP-Seq_HEK293_Human2.41006236
15CLOCK_20551151_ChIP-Seq_293T_Human2.34647450
16NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.24196099
17CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.21334923
18ESR2_21235772_ChIP-Seq_MCF-7_Human2.16877277
19THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.13998917
20MEF2A_21415370_ChIP-Seq_HL-1_Mouse2.12858131
21TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.00284234
22PPARA_22158963_ChIP-Seq_LIVER_Mouse1.96781880
23CTCF_27219007_Chip-Seq_ERYTHROID_Human1.96749177
24KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.96295014
25TET1_21451524_ChIP-Seq_MESCs_Mouse1.94740222
26LXR_22158963_ChIP-Seq_LIVER_Mouse1.94150390
27RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.94134957
28CDX2_19796622_ChIP-Seq_MESCs_Mouse1.91011653
29RXR_22158963_ChIP-Seq_LIVER_Mouse1.90700577
30MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.89764241
31TP63_17297297_ChIP-ChIP_HaCaT_Human1.86450563
32EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.85673181
33BP1_19119308_ChIP-ChIP_Hs578T_Human1.81908645
34* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.76461200
35ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.76327361
36SA1_27219007_Chip-Seq_ERYTHROID_Human1.75710017
37CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.73985721
38TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.73242255
39E2F1_20622854_ChIP-Seq_HELA_Human1.65608757
40TP53_22127205_ChIP-Seq_IMR90_Human1.64444296
41TCF7_22412390_ChIP-Seq_EML_Mouse1.63349698
42TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.62402370
43ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.61156908
44IKZF1_21737484_ChIP-ChIP_HCT116_Human1.58917810
45EZH2_27294783_Chip-Seq_ESCs_Mouse1.58820954
46BCL6_27268052_Chip-Seq_Bcells_Human1.58405491
47BCOR_27268052_Chip-Seq_Bcells_Human1.57896425
48SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.56710065
49KDM2B_26808549_Chip-Seq_SUP-B15_Human1.54859528
50MAF_26560356_Chip-Seq_TH2_Human1.54654053
51FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.54205132
52RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.54070061
53RARB_24833708_ChIP-Seq_LIVER_Mouse1.50948421
54ESR1_21235772_ChIP-Seq_MCF-7_Human1.48829237
55PHF8_20622854_ChIP-Seq_HELA_Human1.47104831
56LXR_22292898_ChIP-Seq_THP-1_Human1.46509762
57RARA_24833708_ChIP-Seq_LIVER_Mouse1.45065881
58PPAR_26484153_Chip-Seq_NCI-H1993_Human1.42860102
59ZFP281_27345836_Chip-Seq_ESCs_Mouse1.42837448
60GATA4_21415370_ChIP-Seq_HL-1_Mouse1.42595369
61CTCF_21964334_Chip-Seq_Bcells_Human1.42369265
62PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.42229619
63PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.39942712
64DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.39843095
65SUZ12_27294783_Chip-Seq_ESCs_Mouse1.39249599
66JARID2_20075857_ChIP-Seq_MESCs_Mouse1.39225153
67NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.37477700
68ELF1_20517297_ChIP-Seq_JURKAT_Human1.37012361
69ELK3_25401928_ChIP-Seq_HUVEC_Human1.36931427
70RACK7_27058665_Chip-Seq_MCF-7_Human1.35162009
71KDM2B_26808549_Chip-Seq_JURKAT_Human1.35124305
72PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.35110209
73BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.34800859
74SRY_22984422_ChIP-ChIP_TESTIS_Rat1.33907246
75CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.32757971
76GATA2_21666600_ChIP-Seq_HMVEC_Human1.29308119
77RXRA_24833708_ChIP-Seq_LIVER_Mouse1.28708615
78CTCF_21964334_ChIP-Seq_BJAB-B_Human1.26738021
79SA1_27219007_Chip-Seq_Bcells_Human1.24793339
80KDM2B_26808549_Chip-Seq_DND41_Human1.23944187
81DROSHA_22980978_ChIP-Seq_HELA_Human1.23135618
82* FOXP1_21924763_ChIP-Seq_HESCs_Human1.21206378
83SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.20758730
84NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.20700660
85MYC_22102868_ChIP-Seq_BL_Human1.20405565
86SOX9_24532713_ChIP-Seq_HFSC_Mouse1.20264819
87KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.20162299
88SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.18849025
89ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.18487375
90TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.17728083
91RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.16838794
92CTCF_27219007_Chip-Seq_Bcells_Human1.16540449
93TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16485206
94VDR_24763502_ChIP-Seq_THP-1_Human1.16087268
95JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.15846249
96OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.15212812
97CJUN_26792858_Chip-Seq_BT549_Human1.15196763
98RARB_27405468_Chip-Seq_BRAIN_Mouse1.14774333
99ATF3_27146783_Chip-Seq_COLON_Human1.13111756
100UBF1/2_26484160_Chip-Seq_HMECs_Human1.12878836
101RUNX1_27514584_Chip-Seq_MCF-7_Human1.12590914
102* TP63_22573176_ChIP-Seq_HFKS_Human1.12556201
103* FOXA2_19822575_ChIP-Seq_HepG2_Human1.10708319
104EED_16625203_ChIP-ChIP_MESCs_Mouse1.10671480
105* MAF_26560356_Chip-Seq_TH1_Human1.10082200
106* CTCF_20526341_ChIP-Seq_ESCs_Human1.09082936
107FOXO3_23340844_ChIP-Seq_DLD1_Human1.08867104
108STAT6_21828071_ChIP-Seq_BEAS2B_Human1.07884528
109RNF2_27304074_Chip-Seq_ESCs_Mouse1.07515116
110YY1_22570637_ChIP-Seq_MALME-3M_Human1.07096007
111KDM2B_26808549_Chip-Seq_K562_Human1.06666510
112UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.06365984
113OCT4_19829295_ChIP-Seq_ESCs_Human1.05832908
114GATA1_19941826_ChIP-Seq_K562_Human1.03203131
115* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.02831453
116* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.02386940
117HIF1A_21447827_ChIP-Seq_MCF-7_Human1.01198023
118EZH2_22144423_ChIP-Seq_EOC_Human1.00788267
119P300_27058665_Chip-Seq_ZR-75-30cells_Human1.00567393
120P63_26484246_Chip-Seq_KERATINOCYTES_Human0.99575645
121NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.98181479
122ISL1_27105846_Chip-Seq_CPCs_Mouse0.97688973
123* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.97454997
124* ZFP281_18757296_ChIP-ChIP_E14_Mouse0.96924585
125* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.96450391
126TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.94376800
127ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.94342915
128CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.94099024
129SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.93463957
130SMC1_22415368_ChIP-Seq_MEFs_Mouse0.92799711
131WT1_25993318_ChIP-Seq_PODOCYTE_Human0.90446702
132* SMC3_22415368_ChIP-Seq_MEFs_Mouse0.89765166
133CTNNB1_20460455_ChIP-Seq_HCT116_Human0.87502815
134* TP53_23651856_ChIP-Seq_MEFs_Mouse0.86356580
135NRF2_20460467_ChIP-Seq_MEFs_Mouse0.85397228
136NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.85397228
137NFIB_24661679_ChIP-Seq_LUNG_Mouse0.85046485
138SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84903857
139CREB1_26743006_Chip-Seq_LNCaP_Human0.84711141
140P68_20966046_ChIP-Seq_HELA_Human0.84584414
141ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.84098287
142SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.83758605
143DNAJC2_21179169_ChIP-ChIP_NT2_Human0.83393613
144MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.83171731
145GATA2_19941826_ChIP-Seq_K562_Human0.82989772
146RNF2_18974828_ChIP-Seq_MESCs_Mouse0.82386893
147EZH2_18974828_ChIP-Seq_MESCs_Mouse0.82386893
148MTF2_20144788_ChIP-Seq_MESCs_Mouse0.81660986
149KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.79377283
150NR3C1_23031785_ChIP-Seq_PC12_Mouse0.79034116
151SMC4_20622854_ChIP-Seq_HELA_Human0.77474098

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis6.78832265
2MP0003646_muscle_fatigue4.91796790
3MP0004084_abnormal_cardiac_muscle4.91669389
4* MP0000751_myopathy4.78580532
5MP0005171_absent_coat_pigmentation4.43406215
6MP0000749_muscle_degeneration4.14258030
7MP0004036_abnormal_muscle_relaxation3.99615268
8* MP0004215_abnormal_myocardial_fiber3.75117482
9MP0005330_cardiomyopathy3.60289104
10MP0005423_abnormal_somatic_nervous3.28415669
11* MP0004087_abnormal_muscle_fiber3.11343124
12MP0003136_yellow_coat_color2.88381853
13MP0001986_abnormal_taste_sensitivity2.83253590
14MP0002972_abnormal_cardiac_muscle2.74984918
15* MP0000750_abnormal_muscle_regeneration2.69354631
16MP0005409_darkened_coat_color2.66131492
17MP0004145_abnormal_muscle_electrophysio2.66062536
18MP0004130_abnormal_muscle_cell2.65707797
19* MP0005620_abnormal_muscle_contractility2.60497557
20* MP0002106_abnormal_muscle_physiology2.57433465
21MP0002269_muscular_atrophy2.50015454
22MP0008775_abnormal_heart_ventricle2.48409862
23MP0010630_abnormal_cardiac_muscle2.40684650
24MP0001544_abnormal_cardiovascular_syste2.32742280
25MP0005385_cardiovascular_system_phenoty2.32742280
26MP0005174_abnormal_tail_pigmentation2.28255543
27* MP0000759_abnormal_skeletal_muscle2.20220143
28* MP0003137_abnormal_impulse_conducting2.20212736
29MP0006138_congestive_heart_failure2.15685406
30* MP0005369_muscle_phenotype2.15151909
31* MP0000747_muscle_weakness2.04989180
32MP0008438_abnormal_cutaneous_collagen2.02838349
33MP0004484_altered_response_of2.02762272
34MP0005670_abnormal_white_adipose1.85364310
35MP0005666_abnormal_adipose_tissue1.84500333
36MP0003828_pulmonary_edema1.82992084
37MP0004085_abnormal_heartbeat1.77286577
38MP0001661_extended_life_span1.75754499
39MP0003705_abnormal_hypodermis_morpholog1.68796851
40MP0004510_myositis1.65885162
41MP0004233_abnormal_muscle_weight1.65847440
42MP0001502_abnormal_circadian_rhythm1.63633068
43MP0003950_abnormal_plasma_membrane1.60365288
44MP0004185_abnormal_adipocyte_glucose1.54641637
45MP0003221_abnormal_cardiomyocyte_apopto1.52052148
46MP0005257_abnormal_intraocular_pressure1.50096441
47MP0005275_abnormal_skin_tensile1.49590803
48MP0003279_aneurysm1.44789073
49MP0002249_abnormal_larynx_morphology1.44271688
50MP0005375_adipose_tissue_phenotype1.41125831
51MP0001188_hyperpigmentation1.37655649
52MP0001348_abnormal_lacrimal_gland1.36136101
53MP0010030_abnormal_orbit_morphology1.33127517
54MP0002127_abnormal_cardiovascular_syste1.31908762
55MP0000733_abnormal_muscle_development1.31453641
56MP0006036_abnormal_mitochondrial_physio1.31206154
57MP0002108_abnormal_muscle_morphology1.30834871
58MP0002332_abnormal_exercise_endurance1.29610299
59MP0003566_abnormal_cell_adhesion1.23385929
60MP0000013_abnormal_adipose_tissue1.19372487
61MP0010368_abnormal_lymphatic_system1.18177455
62MP0002234_abnormal_pharynx_morphology1.14071812
63MP0004858_abnormal_nervous_system1.12594781
64MP0005623_abnormal_meninges_morphology1.11312933
65MP0000343_altered_response_to1.10416979
66MP0000266_abnormal_heart_morphology1.05646658
67MP0001756_abnormal_urination1.03176061
68MP0004859_abnormal_synaptic_plasticity1.02684320
69MP0000003_abnormal_adipose_tissue1.01989654
70MP0003453_abnormal_keratinocyte_physiol1.01202547
71MP0004272_abnormal_basement_membrane0.97108930
72MP0005165_increased_susceptibility_to0.95144519
73MP0000538_abnormal_urinary_bladder0.94643596
74MP0001968_abnormal_touch/_nociception0.94337400
75MP0005076_abnormal_cell_differentiation0.92965141
76MP0003567_abnormal_fetal_cardiomyocyte0.92535389
77MP0002971_abnormal_brown_adipose0.90957832
78MP0000230_abnormal_systemic_arterial0.87585494
79MP0000767_abnormal_smooth_muscle0.84968565
80MP0002128_abnormal_blood_circulation0.84121092
81MP0002909_abnormal_adrenal_gland0.81205828
82MP0002933_joint_inflammation0.80460501
83MP0004270_analgesia0.79708382
84MP0002638_abnormal_pupillary_reflex0.78531813
85MP0001958_emphysema0.74382757
86MP0004381_abnormal_hair_follicle0.74019314
87MP0000534_abnormal_ureter_morphology0.73873318
88MP0001849_ear_inflammation0.73684304
89MP0002254_reproductive_system_inflammat0.72927110
90MP0001879_abnormal_lymphatic_vessel0.71839148
91MP0003045_fibrosis0.71101726
92MP0005058_abnormal_lysosome_morphology0.70028598
93MP0001542_abnormal_bone_strength0.68631486
94MP0005266_abnormal_metabolism0.68630982
95MP0005503_abnormal_tendon_morphology0.67373755
96MP0005508_abnormal_skeleton_morphology0.66335566
97MP0002735_abnormal_chemical_nociception0.65784835
98MP0003879_abnormal_hair_cell0.63968524
99MP0005319_abnormal_enzyme/_coenzyme0.63346355
100MP0003385_abnormal_body_wall0.61695274
101MP0009250_abnormal_appendicular_skeleto0.61506950
102MP0009780_abnormal_chondrocyte_physiolo0.57668908
103MP0009384_cardiac_valve_regurgitation0.57597577
104MP0002932_abnormal_joint_morphology0.55840193
105MP0008875_abnormal_xenobiotic_pharmacok0.55509880
106MP0006035_abnormal_mitochondrial_morpho0.55137921
107MP0001664_abnormal_digestion0.55095589
108MP0008961_abnormal_basal_metabolism0.54782446
109MP0002078_abnormal_glucose_homeostasis0.53781322
110MP0009840_abnormal_foam_cell0.53582006
111MP0003806_abnormal_nucleotide_metabolis0.51608113
112MP0002118_abnormal_lipid_homeostasis0.49613465
113MP0005334_abnormal_fat_pad0.48997057
114MP0002925_abnormal_cardiovascular_devel0.47737544
115MP0009115_abnormal_fat_cell0.46964068
116MP0001614_abnormal_blood_vessel0.46745166
117MP0002877_abnormal_melanocyte_morpholog0.44806177
118MP0001299_abnormal_eye_distance/0.44633147
119MP0004043_abnormal_pH_regulation0.43022767
120MP0002295_abnormal_pulmonary_circulatio0.41176538
121MP0005187_abnormal_penis_morphology0.40714978
122MP0003091_abnormal_cell_migration0.37712162
123MP0005595_abnormal_vascular_smooth0.37672662
124MP0005451_abnormal_body_composition0.36169398
125MP0003252_abnormal_bile_duct0.35985320
126MP0003948_abnormal_gas_homeostasis0.35917130
127MP0002896_abnormal_bone_mineralization0.35817173
128MP0004147_increased_porphyrin_level0.35396886
129MP0002970_abnormal_white_adipose0.34959794
130MP0005083_abnormal_biliary_tract0.34710727
131MP0002060_abnormal_skin_morphology0.33937595
132MP0000249_abnormal_blood_vessel0.33818778
133MP0003195_calcinosis0.32209123
134MP0001784_abnormal_fluid_regulation0.31910644
135MP0000579_abnormal_nail_morphology0.31845496
136MP0005535_abnormal_body_temperature0.30921698
137MP0005023_abnormal_wound_healing0.29824788

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)7.12295204
2Muscle fiber splitting (HP:0003555)6.25954898
3Calf muscle hypertrophy (HP:0008981)6.17396887
4Ventricular tachycardia (HP:0004756)5.97517251
5Exercise-induced myalgia (HP:0003738)5.85953809
6Muscle hypertrophy of the lower extremities (HP:0008968)5.77356049
7Hyporeflexia of lower limbs (HP:0002600)5.60715092
8Exercise-induced muscle cramps (HP:0003710)5.48471479
9Abnormality of the calf musculature (HP:0001430)5.26381711
10Right ventricular cardiomyopathy (HP:0011663)5.15521971
11Increased connective tissue (HP:0009025)4.91246347
12Lipoatrophy (HP:0100578)4.71901795
13* Atrial fibrillation (HP:0005110)4.63873782
14Myoglobinuria (HP:0002913)4.59178057
15Difficulty running (HP:0009046)4.51480751
16Popliteal pterygium (HP:0009756)4.44607203
17EMG: myopathic abnormalities (HP:0003458)4.44063629
18Type 1 muscle fiber predominance (HP:0003803)4.35902035
19Subaortic stenosis (HP:0001682)4.29759055
20Abnormality of the left ventricular outflow tract (HP:0011103)4.29759055
21* Primary atrial arrhythmia (HP:0001692)4.29612454
22Ulnar bowing (HP:0003031)4.27240103
23Fetal akinesia sequence (HP:0001989)4.24103066
24Aplasia of the musculature (HP:0100854)4.15300542
25* Supraventricular tachycardia (HP:0004755)4.11681024
26Thin bony cortex (HP:0002753)4.10873913
27Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.10592013
28Muscle fiber inclusion bodies (HP:0100299)4.08738951
29* Supraventricular arrhythmia (HP:0005115)4.06760715
30Rib fusion (HP:0000902)3.97412206
31Syncope (HP:0001279)3.96408983
32Bundle branch block (HP:0011710)3.94945989
33Dilated cardiomyopathy (HP:0001644)3.94671966
34Turricephaly (HP:0000262)3.94282659
35Asymmetric septal hypertrophy (HP:0001670)3.81518400
36Palpitations (HP:0001962)3.75706992
37Difficulty climbing stairs (HP:0003551)3.72358677
38Prolonged QT interval (HP:0001657)3.65885357
39Akinesia (HP:0002304)3.59561062
40Thin ribs (HP:0000883)3.51313669
41Ventricular arrhythmia (HP:0004308)3.49870065
42Increased variability in muscle fiber diameter (HP:0003557)3.45230339
43Rhabdomyolysis (HP:0003201)3.42477883
44Protrusio acetabuli (HP:0003179)3.42301615
45Nemaline bodies (HP:0003798)3.36319077
46Abnormality of skeletal muscle fiber size (HP:0012084)3.28189666
47Coronal craniosynostosis (HP:0004440)3.23804761
48Mesangial abnormality (HP:0001966)3.20343115
49Annular pancreas (HP:0001734)3.19740275
50Ventricular fibrillation (HP:0001663)3.08419021
51Mildly elevated creatine phosphokinase (HP:0008180)2.89744291
52Neck muscle weakness (HP:0000467)2.86572875
53Round ear (HP:0100830)2.83705625
54Distal lower limb muscle weakness (HP:0009053)2.82056886
55Joint stiffness (HP:0001387)2.81530910
56Limb-girdle muscle atrophy (HP:0003797)2.69772740
57Abnormality of placental membranes (HP:0011409)2.68028905
58Amniotic constriction ring (HP:0009775)2.68028905
59Hemorrhage of the eye (HP:0011885)2.66299531
60Calcaneovalgus deformity (HP:0001848)2.64265875
61* Heart block (HP:0012722)2.63982262
62Muscle stiffness (HP:0003552)2.63327247
63Distal lower limb amyotrophy (HP:0008944)2.63305489
64Distal arthrogryposis (HP:0005684)2.60673147
65Gowers sign (HP:0003391)2.59844779
66* Abnormal atrioventricular conduction (HP:0005150)2.57983993
67Pterygium (HP:0001059)2.57195998
68* Myotonia (HP:0002486)2.56747666
69Scapular winging (HP:0003691)2.55780301
70Aortic aneurysm (HP:0004942)2.55549849
71Abnormal EKG (HP:0003115)2.51739071
72Ketoacidosis (HP:0001993)2.46536950
73Broad metatarsal (HP:0001783)2.42440651
74Areflexia of lower limbs (HP:0002522)2.41338836
75Myopathic facies (HP:0002058)2.39864891
76Intestinal fistula (HP:0100819)2.38738284
77Abnormality of the intrinsic pathway (HP:0010989)2.38394658
78Cervical subluxation (HP:0003308)2.38093815
79Hypoplastic ischia (HP:0003175)2.38029014
80Rectovaginal fistula (HP:0000143)2.34169054
81Rectal fistula (HP:0100590)2.34169054
82Hypoglycemic coma (HP:0001325)2.32737454
83* Atrioventricular block (HP:0001678)2.31983013
84Bladder diverticulum (HP:0000015)2.30605862
85Deformed tarsal bones (HP:0008119)2.30445241
86Dyschromatopsia (HP:0007641)2.27969321
87Shallow orbits (HP:0000586)2.24689570
88Bowing of the arm (HP:0006488)2.24561582
89Bowed forearm bones (HP:0003956)2.24561582
90Poikiloderma (HP:0001029)2.24380875
91Vaginal fistula (HP:0004320)2.23839956
92Palmoplantar keratoderma (HP:0000982)2.23778922
93EMG: neuropathic changes (HP:0003445)2.23756814
94Left ventricular hypertrophy (HP:0001712)2.21883528
95Generalized muscle weakness (HP:0003324)2.20171735
96Spinal rigidity (HP:0003306)2.18909506
97Joint hemorrhage (HP:0005261)2.17867781
98Muscular dystrophy (HP:0003560)2.17018845
99Facial hemangioma (HP:0000329)2.14146974
100Fatigable weakness (HP:0003473)2.12552365
101Abnormality of the neuromuscular junction (HP:0003398)2.12552365
102Hypoplastic heart (HP:0001961)2.10333529
103Vascular tortuosity (HP:0004948)2.08232512
104Obstructive sleep apnea (HP:0002870)2.08051584
105Abnormality of the ischium (HP:0003174)2.07286595
106Abnormality of fatty-acid metabolism (HP:0004359)2.05299405
107Hip contracture (HP:0003273)2.04525328
108Ulnar deviation of the wrist (HP:0003049)2.03895342
109Abnormality of the foot musculature (HP:0001436)2.02827082
110Delayed epiphyseal ossification (HP:0002663)2.01670485
111Proximal amyotrophy (HP:0007126)2.00774621
112Neonatal respiratory distress (HP:0002643)2.00025667
113Foot dorsiflexor weakness (HP:0009027)1.99902913
114Congenital hip dislocation (HP:0001374)1.99772571
115Rimmed vacuoles (HP:0003805)1.99560372
116Arterial tortuosity (HP:0005116)1.99101109
117Attenuation of retinal blood vessels (HP:0007843)1.98791856
118Lower limb amyotrophy (HP:0007210)1.98738001
119Anteriorly placed anus (HP:0001545)1.98725664
120Frequent falls (HP:0002359)1.96186444
121Narrow nasal bridge (HP:0000446)1.94012424
122Ketosis (HP:0001946)1.92118781
123Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.92022382
124Bulbar palsy (HP:0001283)1.91033413
125Sudden cardiac death (HP:0001645)1.90139689
126Abnormality of the calcaneus (HP:0008364)1.90087886
127Choanal stenosis (HP:0000452)1.89453359
128Conjunctival hamartoma (HP:0100780)1.88655973
129Long clavicles (HP:0000890)1.87972190
130Short chin (HP:0000331)1.87501816
131Atrophic scars (HP:0001075)1.86105443
132Neonatal onset (HP:0003623)1.85557414
133Genu recurvatum (HP:0002816)1.85435168
134Dicarboxylic aciduria (HP:0003215)1.85175334
135Abnormality of dicarboxylic acid metabolism (HP:0010995)1.85175334
136Malignant hyperthermia (HP:0002047)1.85054767
137Congestive heart failure (HP:0001635)1.83196285
138Hepatic necrosis (HP:0002605)1.82813090
139Cerebral aneurysm (HP:0004944)1.81534205
140Limb-girdle muscle weakness (HP:0003325)1.80346128
141Weak cry (HP:0001612)1.79754318
142Increased muscle lipid content (HP:0009058)1.79057009
143Large for gestational age (HP:0001520)1.78814761
144Premature rupture of membranes (HP:0001788)1.76681323
145Hyperinsulinemic hypoglycemia (HP:0000825)1.75439291
146Easy fatigability (HP:0003388)1.74805255
147Centrally nucleated skeletal muscle fibers (HP:0003687)1.74236129
148Aneurysm (HP:0002617)1.72934596
149Hamartoma of the eye (HP:0010568)1.69277511
150Dysmetric saccades (HP:0000641)1.68668245
151Ankle contracture (HP:0006466)1.68490650
152Lymphangioma (HP:0100764)1.63697925

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN6.57063378
2MAPK155.49027229
3OBSCN4.08065158
4MYLK3.71841786
5TRIB33.61293914
6PHKG13.59040247
7PHKG23.59040247
8LMTK23.38589687
9DMPK3.13014800
10PKN22.65551871
11PDK32.59843659
12PDK42.59843659
13MUSK2.36230920
14BCKDK2.29815795
15PIK3CA2.04109691
16PDK21.59352566
17EEF2K1.56719928
18TIE11.49188992
19PIK3CG1.46599809
20NEK11.45283807
21PINK11.45199500
22RIPK11.42538397
23MARK11.42037116
24SIK21.38406904
25PRKD21.36404013
26PAK31.33185846
27PDGFRA1.28200115
28NTRK11.28181198
29EPHB11.24243254
30MAP3K71.22842109
31PRKD11.19427500
32SIK11.17629571
33ILK1.14050282
34MAPKAPK31.10249651
35ERN11.07918350
36DYRK1B1.05704229
37ROCK11.04622294
38CAMK2D1.04567660
39INSRR1.03996525
40MAP2K31.01641190
41MAPK121.01244470
42CDC42BPA0.94690843
43STK240.93207477
44PRKAA20.91031886
45MAP2K60.90045615
46MAP3K60.89072590
47BMX0.85043168
48BLK0.84599843
49PTK60.81976713
50ICK0.81722435
51CAMK1D0.81492316
52TGFBR20.81069474
53SMG10.80645947
54TRPM70.80619667
55PRKAA10.78028754
56EPHB20.75702873
57MAP3K30.74753184
58MAPK70.74214195
59LIMK10.72076114
60LATS10.70841834
61DAPK30.70459859
62GRK70.69544443
63ROCK20.69061254
64CAMK1G0.68932194
65WNK40.68868134
66PKN10.66714264
67TYRO30.64468675
68TESK10.63840170
69PAK60.62701152
70FER0.62373754
71CDK150.61836087
72PTK2B0.61835459
73MAP3K50.61239871
74FLT30.61013246
75PRPF4B0.60879074
76ZAP700.60445698
77CDK11A0.60286330
78NME10.58180207
79KSR20.57790512
80MAPK110.57442976
81ADRBK10.56637642
82FGFR40.55465351
83CDK120.54154732
84ZAK0.53312636
85CDK180.53236385
86DDR20.52870270
87MTOR0.52645098
88WNK10.52485648
89NTRK30.52451747
90STK380.52287842
91PAK20.51445452
92ARAF0.50770043
93EPHA30.50110021
94STK38L0.49180776
95EPHA20.49176943
96CAMK40.47717305
97TBK10.47280062
98RPS6KC10.46702546
99RPS6KL10.46702546
100MAPK80.46225038
101STK40.45683062
102PRKACB0.45190100
103PDPK10.45013521
104MET0.44075615
105CAMK2G0.43772075
106MAP2K10.43727457
107PRKCH0.43158203
108CAMK2B0.40281937
109MST1R0.40232724
110CAMK2A0.40160240
111MOS0.40158713
112RPS6KA60.38969882
113MAPK40.38734477
114STK110.38407451
115UHMK10.37912741
116CCNB10.37874344
117KDR0.37735603
118NTRK20.37660038
119MAP2K40.37572733
120CAMK10.37459197
121AKT20.37317944
122LATS20.37011915
123MAPK100.36431017
124MAP3K100.36113790
125PRKD30.35446680
126PAK10.35183463
127PTK20.34781007
128NEK90.33964124
129PRKACG0.33793068
130LRRK20.32458191
131PRKCE0.32334731
132RET0.32157045
133TAOK10.32049612
134PDGFRB0.31411853
135JAK10.29981763
136PRKACA0.28735703
137PRKG20.28347432
138RPS6KA20.28317744
139MARK20.27570161
140MAP3K10.21956277

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.98562049
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.83968833
3Dilated cardiomyopathy_Homo sapiens_hsa054143.75781477
4Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.71785562
5Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006043.49485333
6Cardiac muscle contraction_Homo sapiens_hsa042603.42820509
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.13581467
8Propanoate metabolism_Homo sapiens_hsa006403.07661523
9Sulfur relay system_Homo sapiens_hsa041222.97460386
10Fatty acid degradation_Homo sapiens_hsa000712.94489978
11Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.75962679
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.35764576
13Fatty acid metabolism_Homo sapiens_hsa012122.33687128
14Carbon metabolism_Homo sapiens_hsa012002.15819220
15Glycosaminoglycan degradation_Homo sapiens_hsa005312.13591849
16Parkinsons disease_Homo sapiens_hsa050121.85234902
17Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.75084969
18Oxidative phosphorylation_Homo sapiens_hsa001901.73571636
19Pyruvate metabolism_Homo sapiens_hsa006201.68020968
20PPAR signaling pathway_Homo sapiens_hsa033201.64404192
21Viral myocarditis_Homo sapiens_hsa054161.63699586
22Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.59635028
23Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.55863735
24Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.51671072
25Alzheimers disease_Homo sapiens_hsa050101.48568209
26Hedgehog signaling pathway_Homo sapiens_hsa043401.40204519
27Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.38975445
28Butanoate metabolism_Homo sapiens_hsa006501.37229312
29Melanogenesis_Homo sapiens_hsa049161.32655100
30Insulin resistance_Homo sapiens_hsa049311.30838401
31Adipocytokine signaling pathway_Homo sapiens_hsa049201.27820979
32Starch and sucrose metabolism_Homo sapiens_hsa005001.24695718
33Focal adhesion_Homo sapiens_hsa045101.22178355
34Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.16126002
35Tryptophan metabolism_Homo sapiens_hsa003801.13303564
36Other glycan degradation_Homo sapiens_hsa005111.12654680
37ECM-receptor interaction_Homo sapiens_hsa045121.12108032
38Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.10937106
39Fatty acid elongation_Homo sapiens_hsa000621.10499539
40Glucagon signaling pathway_Homo sapiens_hsa049221.07817756
41Insulin signaling pathway_Homo sapiens_hsa049101.05831250
42Axon guidance_Homo sapiens_hsa043601.05141886
43Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.04680011
44Cocaine addiction_Homo sapiens_hsa050301.03459321
45Arginine biosynthesis_Homo sapiens_hsa002201.03279836
46Lysine degradation_Homo sapiens_hsa003100.99940819
47cGMP-PKG signaling pathway_Homo sapiens_hsa040220.98343085
48Hippo signaling pathway_Homo sapiens_hsa043900.98153842
49Fatty acid biosynthesis_Homo sapiens_hsa000610.97446100
50Basal cell carcinoma_Homo sapiens_hsa052170.96309459
51Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.95847905
52Biosynthesis of amino acids_Homo sapiens_hsa012300.95571892
53Huntingtons disease_Homo sapiens_hsa050160.95057938
54AMPK signaling pathway_Homo sapiens_hsa041520.94842170
55Neurotrophin signaling pathway_Homo sapiens_hsa047220.92531698
56Vascular smooth muscle contraction_Homo sapiens_hsa042700.90491597
57beta-Alanine metabolism_Homo sapiens_hsa004100.88999408
58Circadian entrainment_Homo sapiens_hsa047130.86666208
59Phospholipase D signaling pathway_Homo sapiens_hsa040720.85244676
60Inositol phosphate metabolism_Homo sapiens_hsa005620.85102926
61Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.83375850
62Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.81428993
63Taste transduction_Homo sapiens_hsa047420.80712052
64Cholinergic synapse_Homo sapiens_hsa047250.78573944
65Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.78427221
66Long-term potentiation_Homo sapiens_hsa047200.75286732
67Sphingolipid metabolism_Homo sapiens_hsa006000.75069537
68Tight junction_Homo sapiens_hsa045300.74808768
69Amphetamine addiction_Homo sapiens_hsa050310.72483469
70Estrogen signaling pathway_Homo sapiens_hsa049150.72009075
71Oxytocin signaling pathway_Homo sapiens_hsa049210.71498467
72Arginine and proline metabolism_Homo sapiens_hsa003300.71398608
73Type II diabetes mellitus_Homo sapiens_hsa049300.70970997
74Amoebiasis_Homo sapiens_hsa051460.70888526
75Phenylalanine metabolism_Homo sapiens_hsa003600.69606385
76MAPK signaling pathway_Homo sapiens_hsa040100.69308922
77Glioma_Homo sapiens_hsa052140.66749226
78Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.64358384
79Calcium signaling pathway_Homo sapiens_hsa040200.64182679
80Adherens junction_Homo sapiens_hsa045200.63486717
81Peroxisome_Homo sapiens_hsa041460.61990886
82HIF-1 signaling pathway_Homo sapiens_hsa040660.59274545
83Fat digestion and absorption_Homo sapiens_hsa049750.58812742
84Proteoglycans in cancer_Homo sapiens_hsa052050.58313767
85Endometrial cancer_Homo sapiens_hsa052130.57717676
86Longevity regulating pathway - mammal_Homo sapiens_hsa042110.56771922
87Cyanoamino acid metabolism_Homo sapiens_hsa004600.56759861
88Galactose metabolism_Homo sapiens_hsa000520.56542336
89Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.56084342
90Endocytosis_Homo sapiens_hsa041440.55473135
91Phosphatidylinositol signaling system_Homo sapiens_hsa040700.54915977
92Glutamatergic synapse_Homo sapiens_hsa047240.54173625
93Central carbon metabolism in cancer_Homo sapiens_hsa052300.52679221
94Chronic myeloid leukemia_Homo sapiens_hsa052200.49931844
95Prion diseases_Homo sapiens_hsa050200.49521036
96Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.48976679
97Renin secretion_Homo sapiens_hsa049240.48782549
98Carbohydrate digestion and absorption_Homo sapiens_hsa049730.48604745
99Glycerophospholipid metabolism_Homo sapiens_hsa005640.45601831
100Bile secretion_Homo sapiens_hsa049760.45587378
101Regulation of actin cytoskeleton_Homo sapiens_hsa048100.44841057
102Thyroid hormone signaling pathway_Homo sapiens_hsa049190.44237577
103Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.44216529
104Fructose and mannose metabolism_Homo sapiens_hsa000510.44206450
105Gastric acid secretion_Homo sapiens_hsa049710.43589224
106Morphine addiction_Homo sapiens_hsa050320.43322751
107Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.43047452
108Rap1 signaling pathway_Homo sapiens_hsa040150.42303535
109Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.42183969
110Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.41446579
111cAMP signaling pathway_Homo sapiens_hsa040240.40538721
112Nitrogen metabolism_Homo sapiens_hsa009100.40029281
113Caffeine metabolism_Homo sapiens_hsa002320.38200281
114Glycerolipid metabolism_Homo sapiens_hsa005610.37958038
115Leukocyte transendothelial migration_Homo sapiens_hsa046700.37515862
116Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.34953770
117Insulin secretion_Homo sapiens_hsa049110.33707498
118Circadian rhythm_Homo sapiens_hsa047100.33571989
119Tyrosine metabolism_Homo sapiens_hsa003500.33564241
120Aldosterone synthesis and secretion_Homo sapiens_hsa049250.33496199
121Platelet activation_Homo sapiens_hsa046110.32112892
122Ovarian steroidogenesis_Homo sapiens_hsa049130.29728553
123AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.29534972
124Renal cell carcinoma_Homo sapiens_hsa052110.28778563
125Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.28559379
126ABC transporters_Homo sapiens_hsa020100.28015306
127Dorso-ventral axis formation_Homo sapiens_hsa043200.27580541
128VEGF signaling pathway_Homo sapiens_hsa043700.26512303
129Protein digestion and absorption_Homo sapiens_hsa049740.25959101
130mTOR signaling pathway_Homo sapiens_hsa041500.24563923
131GnRH signaling pathway_Homo sapiens_hsa049120.23319214
132Small cell lung cancer_Homo sapiens_hsa052220.22363284
133Complement and coagulation cascades_Homo sapiens_hsa046100.20559289
134Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.20305200
135Notch signaling pathway_Homo sapiens_hsa043300.17314620
136PI3K-Akt signaling pathway_Homo sapiens_hsa041510.16926971
137Toxoplasmosis_Homo sapiens_hsa051450.16077256
138Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.14635527
139Pancreatic secretion_Homo sapiens_hsa049720.14181126
140FoxO signaling pathway_Homo sapiens_hsa040680.12437497
141Bladder cancer_Homo sapiens_hsa052190.11891209
142Gap junction_Homo sapiens_hsa045400.10629807

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