DMRT3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1xenobiotic catabolic process (GO:0042178)8.16787328
2response to nitrosative stress (GO:0051409)6.83636651
3synapsis (GO:0007129)6.37849444
4chromosome organization involved in meiosis (GO:0070192)5.99482111
5axonemal dynein complex assembly (GO:0070286)5.91406026
6centriole replication (GO:0007099)5.37385985
7male meiosis I (GO:0007141)5.32339879
8epithelial cilium movement (GO:0003351)5.25546097
9regulation of skeletal muscle contraction (GO:0014819)5.19743917
10microtubule depolymerization (GO:0007019)5.00217262
11cilium movement (GO:0003341)4.96182504
12DNA synthesis involved in DNA repair (GO:0000731)4.77689448
13motile cilium assembly (GO:0044458)4.76656964
14mitotic chromosome condensation (GO:0007076)4.67127395
15interleukin-6-mediated signaling pathway (GO:0070102)4.50595602
16regulation of development, heterochronic (GO:0040034)4.49666599
17regulation of gene silencing by RNA (GO:0060966)4.49377042
18regulation of posttranscriptional gene silencing (GO:0060147)4.49377042
19regulation of gene silencing by miRNA (GO:0060964)4.49377042
20cilium or flagellum-dependent cell motility (GO:0001539)4.42266521
21DNA unwinding involved in DNA replication (GO:0006268)4.36966052
22L-ascorbic acid metabolic process (GO:0019852)4.32155736
23generation of neurons (GO:0048699)4.29447805
24meiosis I (GO:0007127)4.28264049
25cerebral cortex neuron differentiation (GO:0021895)4.22560319
26intraciliary transport (GO:0042073)4.17210754
27outer ear morphogenesis (GO:0042473)4.15637848
28sister chromatid cohesion (GO:0007062)4.14309334
29epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.12707232
30regulation of timing of cell differentiation (GO:0048505)4.09538799
31centriole assembly (GO:0098534)4.07928639
32somatic diversification of immune receptors via somatic mutation (GO:0002566)4.05942001
33somatic hypermutation of immunoglobulin genes (GO:0016446)4.05942001
34negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.04467882
35negative regulation of mRNA processing (GO:0050686)4.03927775
36negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)3.96635676
37ganglion development (GO:0061548)3.88741649
38left/right pattern formation (GO:0060972)3.88430832
39meiotic cell cycle process (GO:1903046)3.87756819
40axon extension involved in axon guidance (GO:0048846)3.86326935
41neuron projection extension involved in neuron projection guidance (GO:1902284)3.86326935
42chromosome condensation (GO:0030261)3.85968364
43axoneme assembly (GO:0035082)3.84313679
44olfactory bulb development (GO:0021772)3.79710102
45mitotic G1 DNA damage checkpoint (GO:0031571)3.76706314
46DNA replication checkpoint (GO:0000076)3.75887963
47replication fork processing (GO:0031297)3.73374429
48regulation of female gonad development (GO:2000194)3.72847308
49DNA packaging (GO:0006323)3.71554877
50axonal fasciculation (GO:0007413)3.70091452
51chromatin remodeling at centromere (GO:0031055)3.69891904
52microtubule polymerization or depolymerization (GO:0031109)3.67788847
53synaptonemal complex assembly (GO:0007130)3.66063327
54negative regulation of cell cycle G2/M phase transition (GO:1902750)3.64913131
55piRNA metabolic process (GO:0034587)3.64137971
56DNA ligation (GO:0006266)3.63664414
57relaxation of cardiac muscle (GO:0055119)3.63103670
58protein localization to cilium (GO:0061512)3.61993642
59calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.55178524
60regulation of hippo signaling (GO:0035330)3.52782096
61response to caffeine (GO:0031000)3.52445641
62spermatid nucleus differentiation (GO:0007289)3.51562065
63facial nerve structural organization (GO:0021612)3.51535133
64regulation of cilium movement (GO:0003352)3.50543193
65paraxial mesoderm development (GO:0048339)3.49703517
66synaptonemal complex organization (GO:0070193)3.47343899
67histone exchange (GO:0043486)3.46951655
68positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.45105407
69reciprocal DNA recombination (GO:0035825)3.45002421
70reciprocal meiotic recombination (GO:0007131)3.45002421
71DNA strand elongation involved in DNA replication (GO:0006271)3.44024493
72regulation of DNA endoreduplication (GO:0032875)3.40912247
73retinal ganglion cell axon guidance (GO:0031290)3.39867043
74phenylpropanoid metabolic process (GO:0009698)3.39624193
75CENP-A containing nucleosome assembly (GO:0034080)3.37225458
76metaphase plate congression (GO:0051310)3.34940901
77protein localization to chromosome (GO:0034502)3.33282840
78establishment of nucleus localization (GO:0040023)3.30845148
79positive regulation of male gonad development (GO:2000020)3.29492124
80somite development (GO:0061053)3.28233489
81left/right axis specification (GO:0070986)3.27675236
82formation of translation preinitiation complex (GO:0001731)3.27376869
83positive regulation of neurological system process (GO:0031646)3.25411613
84heterochromatin organization (GO:0070828)3.23281243
85ovulation cycle (GO:0042698)3.23209147
86centrosome duplication (GO:0051298)3.22350495
87DNA strand elongation (GO:0022616)3.21696204
88cilium assembly (GO:0042384)3.20490496
89histone H3-K9 demethylation (GO:0033169)3.19523619
90cilium organization (GO:0044782)3.18866689
91branching involved in salivary gland morphogenesis (GO:0060445)3.18285288
92telomere maintenance via semi-conservative replication (GO:0032201)3.17180387
93kinetochore assembly (GO:0051382)3.14999959
94kinetochore organization (GO:0051383)3.14460648
95glutathione derivative biosynthetic process (GO:1901687)3.14041107
96glutathione derivative metabolic process (GO:1901685)3.14041107
97G1 DNA damage checkpoint (GO:0044783)3.13145087
98oocyte development (GO:0048599)3.12630360
99DNA methylation involved in gamete generation (GO:0043046)3.12098242
100dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.11896994
101fusion of sperm to egg plasma membrane (GO:0007342)3.10271809
102spermatid development (GO:0007286)3.08514654
103negative regulation of RNA splicing (GO:0033119)3.08507052
104translesion synthesis (GO:0019985)3.08492101
105histone H2A acetylation (GO:0043968)3.08105158
106mitotic sister chromatid cohesion (GO:0007064)3.06487634
107negative regulation of DNA recombination (GO:0045910)3.05062782
108DNA damage induced protein phosphorylation (GO:0006975)3.04705991
109mitotic G1/S transition checkpoint (GO:0044819)3.04044099
110cilium morphogenesis (GO:0060271)3.00386519
111negative regulation of mRNA metabolic process (GO:1903312)3.00286183
112dorsal/ventral neural tube patterning (GO:0021904)3.00026609
113mitotic metaphase plate congression (GO:0007080)2.98447498
114DNA double-strand break processing (GO:0000729)2.98401972
115appendage development (GO:0048736)2.98294986
116limb development (GO:0060173)2.98294986
117embryonic body morphogenesis (GO:0010172)2.98026836
118layer formation in cerebral cortex (GO:0021819)2.97995664
119regulation of sister chromatid cohesion (GO:0007063)2.95664231
120negative regulation of axon guidance (GO:1902668)2.95436018
121DNA replication-independent nucleosome assembly (GO:0006336)2.95266188
122DNA replication-independent nucleosome organization (GO:0034724)2.95266188
123attachment of spindle microtubules to kinetochore (GO:0008608)2.94171798
124behavioral response to ethanol (GO:0048149)2.92901762
125negative regulation of axon extension involved in axon guidance (GO:0048843)2.92885715
126negative regulation of astrocyte differentiation (GO:0048712)2.91987536
127establishment of chromosome localization (GO:0051303)2.90501456
128ventricular system development (GO:0021591)2.90362930
129smoothened signaling pathway (GO:0007224)2.89634426
130replicative senescence (GO:0090399)2.89364558
131spinal cord association neuron differentiation (GO:0021527)2.88577928
132male sex determination (GO:0030238)2.87847409
133cell proliferation in forebrain (GO:0021846)2.87690980
134nucleotide-excision repair, DNA gap filling (GO:0006297)2.86414574
135male meiosis (GO:0007140)2.85680269
136histone H3-K36 demethylation (GO:0070544)2.83150755
137DNA strand renaturation (GO:0000733)2.82838184
138body morphogenesis (GO:0010171)2.82307276
139microtubule bundle formation (GO:0001578)2.82252701
140cellular glucuronidation (GO:0052695)2.81157381
141meiotic nuclear division (GO:0007126)2.80480019
142regulation of male gonad development (GO:2000018)2.80222296
143one-carbon compound transport (GO:0019755)2.80221102
144cerebral cortex development (GO:0021987)2.78632595
145regulation of transmission of nerve impulse (GO:0051969)2.78160435
146regulation of nuclear cell cycle DNA replication (GO:0033262)2.77900577
147membrane repolarization during action potential (GO:0086011)2.77751592
148glucuronate metabolic process (GO:0019585)2.76689203
149uronic acid metabolic process (GO:0006063)2.76689203
150bone remodeling (GO:0046849)2.76397327
151mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.76377121
152maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.76235401
153meiotic chromosome segregation (GO:0045132)2.76174287
154cellular response to fluid shear stress (GO:0071498)2.75871410
155protein localization to chromosome, centromeric region (GO:0071459)2.74590295
156ethanol oxidation (GO:0006069)2.74568494
157neuron recognition (GO:0008038)2.74336857
158microtubule severing (GO:0051013)2.74005823
159dentate gyrus development (GO:0021542)2.73843455
160regulation of microtubule-based movement (GO:0060632)2.71938171
161limb bud formation (GO:0060174)2.71030696
162muscle cell cellular homeostasis (GO:0046716)2.70958967
163chromosome organization (GO:0051276)2.69394892
164cornea development in camera-type eye (GO:0061303)2.69350481
165keratinocyte development (GO:0003334)2.69117906
166planar cell polarity pathway involved in neural tube closure (GO:0090179)2.68989644
167regulation of centriole replication (GO:0046599)2.68426003
168tongue development (GO:0043586)2.68266066
169mitotic cell cycle arrest (GO:0071850)2.67731271
170DNA topological change (GO:0006265)2.67031577
171resolution of meiotic recombination intermediates (GO:0000712)2.66962558
172deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.66935354
173benzene-containing compound metabolic process (GO:0042537)2.66488762
174protein-DNA complex disassembly (GO:0032986)2.65611424
175nucleosome disassembly (GO:0006337)2.65611424
176regulation of meiosis I (GO:0060631)2.65316847
177renal absorption (GO:0070293)2.64974303
178response to dietary excess (GO:0002021)2.64670677
179protein polyglutamylation (GO:0018095)2.64288496
180dorsal/ventral pattern formation (GO:0009953)2.64115555
181negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.64112557
182striatum development (GO:0021756)2.63025930
183axon extension (GO:0048675)2.63024129

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.24627330
2EZH2_22144423_ChIP-Seq_EOC_Human4.76721295
3EGR1_19374776_ChIP-ChIP_THP-1_Human4.20561966
4KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.06534817
5KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.06534817
6KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.06534817
7SALL1_21062744_ChIP-ChIP_HESCs_Human3.37116984
8RBPJ_22232070_ChIP-Seq_NCS_Mouse3.30797650
9AR_21909140_ChIP-Seq_LNCAP_Human3.27558037
10ZFP281_18358816_ChIP-ChIP_MESCs_Mouse3.20875472
11TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.05202315
12SOX2_18555785_ChIP-Seq_MESCs_Mouse2.97950464
13TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.78662264
14* CBX2_27304074_Chip-Seq_ESCs_Mouse2.57358812
15FOXM1_23109430_ChIP-Seq_U2OS_Human2.54846778
16GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.49369806
17TAF15_26573619_Chip-Seq_HEK293_Human2.45302707
18E2F4_17652178_ChIP-ChIP_JURKAT_Human2.41590826
19NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.35948928
20ZNF263_19887448_ChIP-Seq_K562_Human2.33528507
21ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.24929811
22TCF3_18692474_ChIP-Seq_MEFs_Mouse2.23208147
23MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.16983716
24FUS_26573619_Chip-Seq_HEK293_Human2.15708301
25MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.02464563
26SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.99037172
27POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.98236715
28* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.94545901
29FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.92578131
30IGF1R_20145208_ChIP-Seq_DFB_Human1.91751304
31POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.90899864
32E2F1_21310950_ChIP-Seq_MCF-7_Human1.90389789
33* EZH2_27304074_Chip-Seq_ESCs_Mouse1.89799648
34ZFP281_27345836_Chip-Seq_ESCs_Mouse1.89034507
35ZFP281_18757296_ChIP-ChIP_E14_Mouse1.88943152
36TP63_19390658_ChIP-ChIP_HaCaT_Human1.85827605
37TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.83038244
38TCF3_18692474_ChIP-Seq_MESCs_Mouse1.81982568
39CTBP2_25329375_ChIP-Seq_LNCAP_Human1.79580273
40POU3F2_20337985_ChIP-ChIP_501MEL_Human1.78975350
41CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.78602427
42* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.77585357
43SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.77379182
44MYC_18555785_ChIP-Seq_MESCs_Mouse1.74918906
45* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.71432990
46ERG_21242973_ChIP-ChIP_JURKAT_Human1.70139307
47ZFP57_27257070_Chip-Seq_ESCs_Mouse1.66491472
48ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.65581795
49CTBP1_25329375_ChIP-Seq_LNCAP_Human1.63291496
50* RNF2_27304074_Chip-Seq_NSC_Mouse1.60363961
51NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.58762787
52STAT3_1855785_ChIP-Seq_MESCs_Mouse1.55413783
53TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.54272162
54EWS_26573619_Chip-Seq_HEK293_Human1.53964554
55MYC_19079543_ChIP-ChIP_MESCs_Mouse1.52336431
56NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.50326488
57CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.49655116
58IRF1_19129219_ChIP-ChIP_H3396_Human1.48494926
59ZNF274_21170338_ChIP-Seq_K562_Hela1.48296546
60* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.47628544
61CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.45192873
62GATA1_26923725_Chip-Seq_HPCs_Mouse1.44755380
63* RING1B_27294783_Chip-Seq_NPCs_Mouse1.44042250
64* P300_19829295_ChIP-Seq_ESCs_Human1.43159820
65* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.42395040
66SOX2_18692474_ChIP-Seq_MEFs_Mouse1.42310306
67* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.41797398
68KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.40505926
69* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.40332632
70BCAT_22108803_ChIP-Seq_LS180_Human1.40226836
71SOX2_16153702_ChIP-ChIP_HESCs_Human1.39216750
72NELFA_20434984_ChIP-Seq_ESCs_Mouse1.37945238
73SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.37563557
74* RNF2_27304074_Chip-Seq_ESCs_Mouse1.37389194
75* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.35741472
76SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.35599794
77* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.34134341
78TOP2B_26459242_ChIP-Seq_MCF-7_Human1.33415199
79* EED_16625203_ChIP-ChIP_MESCs_Mouse1.33231559
80CLOCK_20551151_ChIP-Seq_293T_Human1.30884923
81FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.30404618
82TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30272295
83POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.30272295
84ER_23166858_ChIP-Seq_MCF-7_Human1.30023836
85SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.29652087
86POU5F1_16153702_ChIP-ChIP_HESCs_Human1.29208642
87SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.28540116
88ESR1_20079471_ChIP-ChIP_T-47D_Human1.27015860
89VDR_22108803_ChIP-Seq_LS180_Human1.27006807
90HIF1A_21447827_ChIP-Seq_MCF-7_Human1.24674056
91POU5F1_16518401_ChIP-PET_MESCs_Mouse1.24253177
92ESR1_21235772_ChIP-Seq_MCF-7_Human1.24244859
93SOX2_18692474_ChIP-Seq_MESCs_Mouse1.23625021
94AR_25329375_ChIP-Seq_VCAP_Human1.22904767
95POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.22727869
96WT1_19549856_ChIP-ChIP_CCG9911_Human1.22205965
97THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.18510281
98CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.17398744
99CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.17029706
100SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.16812941
101HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.16481423
102E2F1_18555785_ChIP-Seq_MESCs_Mouse1.16430935
103SMAD3_21741376_ChIP-Seq_EPCs_Human1.15897466
104* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.14361594
105NANOG_21062744_ChIP-ChIP_HESCs_Human1.14308166
106SOX9_26525672_Chip-Seq_HEART_Mouse1.12943393
107MYC_19030024_ChIP-ChIP_MESCs_Mouse1.12770541
108SMAD4_21799915_ChIP-Seq_A2780_Human1.12132322
109BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.11453535
110PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.11399188
111* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.10424127
112CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.09686260
113* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.07980171
114* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.07980171
115ESR1_15608294_ChIP-ChIP_MCF-7_Human1.07625298
116NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.07562368
117STAT6_21828071_ChIP-Seq_BEAS2B_Human1.05693990
118RUNX2_22187159_ChIP-Seq_PCA_Human1.05128674
119OCT4_18692474_ChIP-Seq_MEFs_Mouse1.03732457
120SOX2_27498859_Chip-Seq_STOMACH_Mouse1.03644244
121CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.03634133
122NANOG_18692474_ChIP-Seq_MEFs_Mouse1.03623760
123NR3C1_21868756_ChIP-Seq_MCF10A_Human1.03504810
124TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03139803
125ESR2_21235772_ChIP-Seq_MCF-7_Human1.02596694
126RACK7_27058665_Chip-Seq_MCF-7_Human1.02559566
127REST_21632747_ChIP-Seq_MESCs_Mouse1.02251913
128PKCTHETA_26484144_Chip-Seq_BREAST_Human1.02087218
129* RUNX1_27514584_Chip-Seq_MCF-7_Human1.00900599
130ZNF217_24962896_ChIP-Seq_MCF-7_Human1.00554330
131TRIM28_21343339_ChIP-Seq_HEK293_Human1.00425274
132SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.99866515
133PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.99272885
134TDRD3_21172665_ChIP-Seq_MCF-7_Human0.98817768
135MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.97590740
136NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.97488641
137AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.97404178
138TBL1_22424771_ChIP-Seq_293T_Human0.97273045
139KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.97118033
140* EZH2_27294783_Chip-Seq_ESCs_Mouse0.96239810
141CHD1_26751641_Chip-Seq_LNCaP_Human0.95990992
142STAT3_23295773_ChIP-Seq_U87_Human0.95004519
143KLF5_20875108_ChIP-Seq_MESCs_Mouse0.94171313
144* SUZ12_27294783_Chip-Seq_ESCs_Mouse0.93974330
145KLF4_18555785_ChIP-Seq_MESCs_Mouse0.93601808
146PIAS1_25552417_ChIP-Seq_VCAP_Human0.92583410
147NFYB_21822215_ChIP-Seq_K562_Human0.91582483
148* NANOG_16153702_ChIP-ChIP_HESCs_Human0.91203253
149WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.91149232
150CBP_20019798_ChIP-Seq_JUKART_Human0.90156978
151IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.90156978
152* SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.90015332
153FOXM1_26456572_ChIP-Seq_MCF-7_Human0.89178798
154WDR5_24793694_ChIP-Seq_LNCAP_Human0.88397976
155TCF4_23295773_ChIP-Seq_U87_Human0.87981204
156NFIB_24661679_ChIP-Seq_LUNG_Mouse0.87780134
157NANOG_18692474_ChIP-Seq_MESCs_Mouse0.87461209
158KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.87242231
159* SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.87056611
160ZFX_18555785_ChIP-Seq_MESCs_Mouse0.86948341
161SMAD4_21741376_ChIP-Seq_EPCs_Human0.86837682
162NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.86514966
163DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.86286334
164MYC_18940864_ChIP-ChIP_HL60_Human0.85988760
165* RING1B_27294783_Chip-Seq_ESCs_Mouse0.85887067
166REST_18959480_ChIP-ChIP_MESCs_Mouse0.85156490
167PHF8_20622853_ChIP-Seq_HELA_Human0.84230822
168GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84163504
169EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.84153922
170CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.83794138
171EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.83225664
172OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.83104003
173POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.81461924
174ETV1_20927104_ChIP-Seq_GIST48_Human0.81438249
175PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.81117540
176EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.80698607
177JUN_21703547_ChIP-Seq_K562_Human0.80616490
178MYCN_18555785_ChIP-Seq_MESCs_Mouse0.80142042
179NANOG_18555785_Chip-Seq_ESCs_Mouse0.79828614
180CREB1_26743006_Chip-Seq_LNCaP_Human0.79606006
181FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.79459175

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005499_abnormal_olfactory_system4.98240854
2MP0005394_taste/olfaction_phenotype4.98240854
3MP0008789_abnormal_olfactory_epithelium4.71649320
4MP0010030_abnormal_orbit_morphology3.94704123
5MP0010352_gastrointestinal_tract_polyps2.99448644
6MP0003878_abnormal_ear_physiology2.77521361
7MP0005377_hearing/vestibular/ear_phenot2.77521361
8MP0001346_abnormal_lacrimal_gland2.71192799
9MP0001984_abnormal_olfaction2.68550267
10MP0008057_abnormal_DNA_replication2.68113030
11MP0003880_abnormal_central_pattern2.51665059
12MP0002653_abnormal_ependyma_morphology2.49694816
13MP0009053_abnormal_anal_canal2.46692434
14MP0006292_abnormal_olfactory_placode2.41138633
15MP0008875_abnormal_xenobiotic_pharmacok2.32203326
16MP0008995_early_reproductive_senescence2.26748949
17MP0003890_abnormal_embryonic-extraembry2.01620131
18MP0008877_abnormal_DNA_methylation2.01244614
19MP0002233_abnormal_nose_morphology2.00045150
20MP0000678_abnormal_parathyroid_gland1.94842013
21MP0010094_abnormal_chromosome_stability1.93998874
22MP0003787_abnormal_imprinting1.82737968
23MP0002009_preneoplasia1.81096603
24MP0000049_abnormal_middle_ear1.79013905
25MP0002210_abnormal_sex_determination1.78134968
26MP0003122_maternal_imprinting1.66479885
27MP0004133_heterotaxia1.63649972
28MP0002163_abnormal_gland_morphology1.61861884
29MP0002822_catalepsy1.61311249
30MP0003121_genomic_imprinting1.60302805
31MP0000537_abnormal_urethra_morphology1.54694981
32MP0000467_abnormal_esophagus_morphology1.48327523
33MP0002160_abnormal_reproductive_system1.46782843
34MP0003119_abnormal_digestive_system1.45625407
35MP0002249_abnormal_larynx_morphology1.43977463
36MP0002234_abnormal_pharynx_morphology1.42992661
37MP0003755_abnormal_palate_morphology1.38364096
38MP0003136_yellow_coat_color1.36581622
39MP0000566_synostosis1.34034719
40MP0003186_abnormal_redox_activity1.32491045
41MP0001293_anophthalmia1.31961466
42MP0005248_abnormal_Harderian_gland1.31141271
43MP0001145_abnormal_male_reproductive1.30019811
44MP0002254_reproductive_system_inflammat1.28814462
45MP0003690_abnormal_glial_cell1.28718908
46MP0000762_abnormal_tongue_morphology1.28285064
47MP0008058_abnormal_DNA_repair1.27515380
48MP0003937_abnormal_limbs/digits/tail_de1.26838882
49MP0000613_abnormal_salivary_gland1.26653451
50MP0009278_abnormal_bone_marrow1.26259361
51MP0000383_abnormal_hair_follicle1.26081399
52MP0002697_abnormal_eye_size1.23978298
53MP0002932_abnormal_joint_morphology1.23708558
54MP0000778_abnormal_nervous_system1.23497426
55MP0003123_paternal_imprinting1.22582253
56MP0005171_absent_coat_pigmentation1.21221990
57MP0001929_abnormal_gametogenesis1.20906464
58MP0003111_abnormal_nucleus_morphology1.20688650
59MP0000681_abnormal_thyroid_gland1.18889591
60MP0000653_abnormal_sex_gland1.18644512
61MP0003077_abnormal_cell_cycle1.18396458
62MP0005646_abnormal_pituitary_gland1.14878654
63MP0001485_abnormal_pinna_reflex1.14247140
64MP0000350_abnormal_cell_proliferation1.13184486
65MP0004043_abnormal_pH_regulation1.13153404
66MP0006072_abnormal_retinal_apoptosis1.11127501
67MP0002098_abnormal_vibrissa_morphology1.10771310
68MP0005195_abnormal_posterior_eye1.10744086
69MP0000026_abnormal_inner_ear1.09966416
70MP0002396_abnormal_hematopoietic_system1.09470954
71MP0002084_abnormal_developmental_patter1.07561049
72MP0009379_abnormal_foot_pigmentation1.07483192
73MP0002152_abnormal_brain_morphology1.07395586
74MP0005076_abnormal_cell_differentiation1.06967658
75MP0005391_vision/eye_phenotype1.06874598
76MP0002184_abnormal_innervation1.06178962
77MP0004264_abnormal_extraembryonic_tissu1.04453468
78MP0009250_abnormal_appendicular_skeleto1.03838255
79MP0000534_abnormal_ureter_morphology1.03110792
80MP0000427_abnormal_hair_cycle1.02852249
81MP0004885_abnormal_endolymph1.02467954
82MP0003941_abnormal_skin_development1.01966903
83MP0005187_abnormal_penis_morphology1.01456739
84MP0006276_abnormal_autonomic_nervous1.01365685
85MP0004742_abnormal_vestibular_system1.01316045
86MP0002085_abnormal_embryonic_tissue1.01070900
87MP0009384_cardiac_valve_regurgitation1.00867207
88MP0002111_abnormal_tail_morphology1.00505369
89MP0009703_decreased_birth_body0.99551986
90MP0002752_abnormal_somatic_nervous0.99363427
91MP0005551_abnormal_eye_electrophysiolog0.99087972
92MP0003786_premature_aging0.98754505
93MP0002161_abnormal_fertility/fecundity0.98408741
94MP0001119_abnormal_female_reproductive0.98374698
95MP0000955_abnormal_spinal_cord0.98150169
96MP0001672_abnormal_embryogenesis/_devel0.97236373
97MP0005380_embryogenesis_phenotype0.97236373
98MP0001529_abnormal_vocalization0.96397121
99MP0003861_abnormal_nervous_system0.95413391
100MP0009046_muscle_twitch0.95352429
101MP0003935_abnormal_craniofacial_develop0.93898632
102MP0004197_abnormal_fetal_growth/weight/0.93713799
103MP0002092_abnormal_eye_morphology0.93156459
104MP0003385_abnormal_body_wall0.92786423
105MP0001486_abnormal_startle_reflex0.91368301
106MP0000372_irregular_coat_pigmentation0.90759934
107MP0005408_hypopigmentation0.89021702
108MP0005379_endocrine/exocrine_gland_phen0.88973710
109* MP0002116_abnormal_craniofacial_bone0.88483008
110MP0000432_abnormal_head_morphology0.88223404
111MP0002928_abnormal_bile_duct0.87746175
112MP0010678_abnormal_skin_adnexa0.86732099
113MP0002109_abnormal_limb_morphology0.86442210
114MP0000428_abnormal_craniofacial_morphol0.86402814
115MP0002882_abnormal_neuron_morphology0.86370971
116MP0001730_embryonic_growth_arrest0.86347117
117MP0003693_abnormal_embryo_hatching0.85948950
118MP0001286_abnormal_eye_development0.85575904
119MP0003718_maternal_effect0.85135412
120MP0000631_abnormal_neuroendocrine_gland0.84735437
121MP0003315_abnormal_perineum_morphology0.83744307
122MP0004019_abnormal_vitamin_homeostasis0.83667754
123MP0008932_abnormal_embryonic_tissue0.82847221
124MP0000733_abnormal_muscle_development0.81968881
125MP0003984_embryonic_growth_retardation0.81336329
126MP0000579_abnormal_nail_morphology0.81069128
127MP0003698_abnormal_male_reproductive0.80691567
128MP0003283_abnormal_digestive_organ0.80424168
129MP0002876_abnormal_thyroid_physiology0.80412339
130MP0004957_abnormal_blastocyst_morpholog0.80333448
131MP0005266_abnormal_metabolism0.80226751
132MP0003938_abnormal_ear_development0.79040265
133MP0002751_abnormal_autonomic_nervous0.79019008
134MP0002282_abnormal_trachea_morphology0.78038695
135MP0002088_abnormal_embryonic_growth/wei0.77731442
136* MP0003936_abnormal_reproductive_system0.76952576
137MP0004811_abnormal_neuron_physiology0.76377890
138MP0002132_abnormal_respiratory_system0.74070803
139MP0003942_abnormal_urinary_system0.73978238
140MP0002938_white_spotting0.73479716
141MP0005623_abnormal_meninges_morphology0.73436978
142MP0001915_intracranial_hemorrhage0.71762625
143MP0005367_renal/urinary_system_phenotyp0.71651327
144MP0000516_abnormal_urinary_system0.71651327
145MP0005389_reproductive_system_phenotype0.70927103
146MP0001849_ear_inflammation0.68866502

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.60718950
2Absent/shortened dynein arms (HP:0200106)4.72267159
3Dynein arm defect of respiratory motile cilia (HP:0012255)4.72267159
4Abnormal respiratory motile cilium physiology (HP:0012261)4.52006580
5Abnormal respiratory epithelium morphology (HP:0012253)4.37001862
6Abnormal respiratory motile cilium morphology (HP:0005938)4.37001862
7Abnormal ciliary motility (HP:0012262)4.14627366
8Volvulus (HP:0002580)3.97403774
9Lip pit (HP:0100267)3.89878495
10Rhinitis (HP:0012384)3.85902608
11Median cleft lip (HP:0000161)3.79769872
12Esophageal atresia (HP:0002032)3.52613847
13Impulsivity (HP:0100710)3.49054920
14Oligodactyly (hands) (HP:0001180)3.39050758
15Vaginal fistula (HP:0004320)3.27079480
16Absent thumb (HP:0009777)3.22437685
17Chronic bronchitis (HP:0004469)3.21498261
18Pancreatic fibrosis (HP:0100732)3.20684052
19Facial cleft (HP:0002006)3.18720762
20Nephronophthisis (HP:0000090)3.17977877
21Abnormal spermatogenesis (HP:0008669)3.17567240
22Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)3.17179124
23Oligodactyly (HP:0012165)3.16695346
24Rib fusion (HP:0000902)3.12585426
25Thyroid-stimulating hormone excess (HP:0002925)3.09278486
26Abnormality of midbrain morphology (HP:0002418)2.98641560
27Molar tooth sign on MRI (HP:0002419)2.98641560
28Irregular epiphyses (HP:0010582)2.98057028
29Colon cancer (HP:0003003)2.88328539
30Medial flaring of the eyebrow (HP:0010747)2.87865638
31Gait imbalance (HP:0002141)2.86153126
32Congenital primary aphakia (HP:0007707)2.86035453
33Stenosis of the external auditory canal (HP:0000402)2.81687718
34Popliteal pterygium (HP:0009756)2.81432346
35Abnormality of the labia minora (HP:0012880)2.80598392
36Broad distal phalanx of finger (HP:0009836)2.77951773
37Gastrointestinal atresia (HP:0002589)2.67048425
38Periauricular skin pits (HP:0100277)2.66491459
39Preauricular pit (HP:0004467)2.66491459
4011 pairs of ribs (HP:0000878)2.62891062
41Postaxial foot polydactyly (HP:0001830)2.61929383
42Bifid scrotum (HP:0000048)2.61457176
43Rectal fistula (HP:0100590)2.60990502
44Rectovaginal fistula (HP:0000143)2.60990502
45Pelvic girdle muscle weakness (HP:0003749)2.59365953
46Persistence of primary teeth (HP:0006335)2.57153800
47Septo-optic dysplasia (HP:0100842)2.56901680
48Abnormality of the renal medulla (HP:0100957)2.56662493
49Urethral obstruction (HP:0000796)2.56449607
50Abnormality of the nasal septum (HP:0000419)2.54236834
51Nephrogenic diabetes insipidus (HP:0009806)2.53496616
52Abnormality of dentin (HP:0010299)2.53208653
53Missing ribs (HP:0000921)2.52128993
54Aplasia/Hypoplasia of the scapulae (HP:0006713)2.51580571
55Hypoplastic scapulae (HP:0000882)2.51580571
56Hypoplastic labia majora (HP:0000059)2.50258913
57Tubulointerstitial nephritis (HP:0001970)2.48131044
58Occipital encephalocele (HP:0002085)2.46764649
59Bronchiectasis (HP:0002110)2.46009965
60Ectopic kidney (HP:0000086)2.44929567
61Anencephaly (HP:0002323)2.44768188
62Chronic hepatic failure (HP:0100626)2.44298104
63Pancreatic cysts (HP:0001737)2.44252647
64Hypoplastic iliac wings (HP:0002866)2.43908366
65Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.43498139
66Preaxial hand polydactyly (HP:0001177)2.42195030
67Choanal stenosis (HP:0000452)2.41675652
68Postaxial hand polydactyly (HP:0001162)2.41263815
69Abnormality of the aortic arch (HP:0012303)2.39638289
70Shoulder girdle muscle weakness (HP:0003547)2.38846380
71Azoospermia (HP:0000027)2.34292639
72Genital tract atresia (HP:0001827)2.33670985
73Vaginal atresia (HP:0000148)2.31668525
74Rhabdomyosarcoma (HP:0002859)2.31032395
75Skin pits (HP:0100276)2.30176492
76Cerebellar dysplasia (HP:0007033)2.25673230
77Hemivertebrae (HP:0002937)2.24911854
78Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.24416236
79Facial hemangioma (HP:0000329)2.24258948
80Abnormal hemoglobin (HP:0011902)2.23539967
81Microglossia (HP:0000171)2.23465561
82Sclerocornea (HP:0000647)2.22870506
83Abnormality of the anterior horn cell (HP:0006802)2.22818017
84Degeneration of anterior horn cells (HP:0002398)2.22818017
85Annular pancreas (HP:0001734)2.22751482
86Carpal synostosis (HP:0009702)2.22432182
87Abnormality of the lower motor neuron (HP:0002366)2.22279577
88Hypoplastic pelvis (HP:0008839)2.21716494
89Labial hypoplasia (HP:0000066)2.21681542
90Lissencephaly (HP:0001339)2.21386931
91Male pseudohermaphroditism (HP:0000037)2.20996811
92Ulnar bowing (HP:0003031)2.19999987
93Fibular aplasia (HP:0002990)2.19667695
94Intestinal fistula (HP:0100819)2.19483005
95Abnormality of the labia majora (HP:0012881)2.18794161
96Hypoplastic female external genitalia (HP:0012815)2.17504885
97Stomach cancer (HP:0012126)2.17477283
98Vertebral hypoplasia (HP:0008417)2.15210770
99Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.15210770
100Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.14025214
101Aplasia/Hypoplasia of the patella (HP:0006498)2.13623686
102Abnormality of the hip-girdle musculature (HP:0001445)2.12019540
103Abnormality of the musculature of the pelvis (HP:0001469)2.12019540
104Sloping forehead (HP:0000340)2.11986288
105Intellectual disability, moderate (HP:0002342)2.09686574
106Aplasia/Hypoplasia of the tongue (HP:0010295)2.07845578
107Anophthalmia (HP:0000528)2.07271673
108Atresia of the external auditory canal (HP:0000413)2.07112385
109Biliary tract neoplasm (HP:0100574)2.05270526
110Tented upper lip vermilion (HP:0010804)2.05245062
111Absent eyebrow (HP:0002223)2.02451576
112Poor coordination (HP:0002370)2.02303769
113Hypoplasia of the ulna (HP:0003022)2.02174994
114Abnormality of the phalanges of the 2nd finger (HP:0009541)2.01062681
115Ependymoma (HP:0002888)2.00047290
116Abnormality of the 4th metacarpal (HP:0010012)1.99879967
117Premature graying of hair (HP:0002216)1.99796835
118Bifid tongue (HP:0010297)1.99313276
119Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.98486775
120Holoprosencephaly (HP:0001360)1.98470423
121Broad thumb (HP:0011304)1.97553378
122Broad foot (HP:0001769)1.95726630
123Hypoplasia of the uterus (HP:0000013)1.94935274
124Breast aplasia (HP:0100783)1.94852586
125Medulloblastoma (HP:0002885)1.92789804
126Trismus (HP:0000211)1.92631166
127Broad finger (HP:0001500)1.92118097
128Neoplasm of striated muscle (HP:0009728)1.91055008
129Aplasia/Hypoplasia of the breasts (HP:0010311)1.90219523
130Abnormality of cochlea (HP:0000375)1.89061776
131Abnormality of the diencephalon (HP:0010662)1.88733624
132Type II lissencephaly (HP:0007260)1.88363017
133Infertility (HP:0000789)1.88258794
134Absent radius (HP:0003974)1.88168155
135Broad phalanges of the hand (HP:0009768)1.88131953
136Turricephaly (HP:0000262)1.87719455
137Multicystic kidney dysplasia (HP:0000003)1.86182300
138Optic nerve hypoplasia (HP:0000609)1.84010521
139Intestinal atresia (HP:0011100)1.82946324
140Congenital hepatic fibrosis (HP:0002612)1.82661991
141Synostosis involving bones of the hand (HP:0004278)1.82351435
142Aplasia/hypoplasia of the uterus (HP:0008684)1.81955957
143Aplasia/Hypoplasia of the ulna (HP:0006495)1.81713713
144Carpal bone hypoplasia (HP:0001498)1.81516302
145Abnormality of chromosome stability (HP:0003220)1.81415959
146Disproportionate short-trunk short stature (HP:0003521)1.79862264
147Cystic liver disease (HP:0006706)1.79802649
148Selective tooth agenesis (HP:0001592)1.79462623
149Absent eyelashes (HP:0000561)1.79024355
150Abnormality of the proximal phalanges of the hand (HP:0009834)1.78961460
151Abnormal sex determination (HP:0012244)1.78837566
152Sex reversal (HP:0012245)1.78837566
153Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.78830175
154Short 1st metacarpal (HP:0010034)1.78830175
155Absent forearm bone (HP:0003953)1.78425058
156Aplasia involving forearm bones (HP:0009822)1.78425058
157Glioma (HP:0009733)1.78340956
158Synostosis of carpal bones (HP:0005048)1.77238296
159Supernumerary ribs (HP:0005815)1.76619174
160Abnormality of the phalanges of the 5th finger (HP:0004213)1.76439365
161True hermaphroditism (HP:0010459)1.76167059
162Broad phalanx (HP:0006009)1.74440298
163Prominent nasal bridge (HP:0000426)1.73599186
164Nasal polyposis (HP:0100582)1.71830376
165Abnormality of lateral ventricle (HP:0030047)1.71745431
166Aganglionic megacolon (HP:0002251)1.70965377
167Micropenis (HP:0000054)1.70889757
168Morphological abnormality of the inner ear (HP:0011390)1.70600911
169Hypoplastic ilia (HP:0000946)1.70444523
170Renal dysplasia (HP:0000110)1.69154834
171Tubulointerstitial abnormality (HP:0001969)1.68268232
172Gonadotropin excess (HP:0000837)1.68150001
173Cutaneous finger syndactyly (HP:0010554)1.67708728
174Abnormality of the pubic bones (HP:0003172)1.67604031
175Astigmatism (HP:0000483)1.67059802
176Aplasia/Hypoplasia of the sacrum (HP:0008517)1.66982530
177Dandy-Walker malformation (HP:0001305)1.66668938
178Truncal obesity (HP:0001956)1.64819911
179Optic nerve coloboma (HP:0000588)1.64351176
180Aplasia/Hypoplasia of the sternum (HP:0006714)1.64291597
181Specific learning disability (HP:0001328)1.62956673
182Abnormal lung lobation (HP:0002101)1.62158190
183Amyotrophic lateral sclerosis (HP:0007354)1.61811810
184Decreased testicular size (HP:0008734)1.58221857

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC76.03653457
2PNCK5.98036952
3CDK193.66312538
4MAP3K103.30595828
5CASK3.29416301
6MAPK152.90222491
7MAP3K22.85911917
8MST42.80278172
9MAP3K32.48610037
10CDK122.46439791
11ERBB32.42067410
12EPHA42.28116085
13MAP2K62.25687409
14HIPK22.12363329
15MAP3K42.05036388
16PHKG22.00995222
17PHKG12.00995222
18EPHB21.93802686
19BRSK21.93468219
20WNK31.90114428
21OXSR11.79434119
22ICK1.71411527
23CAMK1G1.70209184
24ADRBK21.64249463
25TYRO31.64156011
26CDK81.62503360
27CCNB11.61968050
28DYRK31.56622597
29RPS6KA41.54889823
30CDK61.48707975
31SIK31.48124225
32RPS6KB21.45003928
33CDK71.44765662
34EPHA21.41097462
35NUAK11.40162715
36MINK11.39491925
37TTK1.37858585
38SIK11.36010499
39PDK31.35842942
40PDK41.35842942
41ATR1.34861096
42MAPK131.34817794
43NEK11.34659215
44TNIK1.34311547
45TAOK11.32076898
46PBK1.30459740
47BMPR21.29330586
48DYRK1B1.28449939
49TAF11.24504159
50TESK11.22314526
51PIK3CA1.16304831
52STK31.16237661
53MKNK21.15526088
54MKNK11.12343647
55CHEK21.10972245
56MET1.08630221
57STK161.07282934
58TRIM281.03905695
59NEK21.03543007
60EPHA31.01196023
61FRK1.00726246
62DAPK20.94143386
63CDK30.93704322
64SRPK10.93482548
65MAP4K20.91636211
66PLK10.91385661
67MAP2K30.88004560
68UHMK10.87554671
69NME10.87193660
70MARK10.86168593
71PINK10.84325963
72PKN10.84307481
73PDK20.83801785
74BRD40.83590080
75AURKA0.82759303
76STK38L0.82013947
77DYRK20.81719430
78MATK0.81714374
79VRK20.81104000
80PAK30.80825029
81DDR20.80355773
82AURKB0.77689274
83BCR0.76673846
84PLK20.74985546
85STK240.74947513
86BRSK10.74688248
87SIK20.72909792
88WEE10.72260308
89GRK60.71408483
90BUB10.70713884
91CDK90.70527237
92CHEK10.70006176
93VRK10.69738730
94STK100.69696406
95PLK40.69192126
96ERBB20.68830902
97ALK0.67967117
98ATM0.67596273
99PLK30.66958977
100STK40.66899633
101PRKCG0.66057108
102CSNK1G20.64970140
103MAPK70.62165803
104MAP2K20.61970581
105SMG10.60962911
106NLK0.60812264
107BCKDK0.60599112
108CAMK10.60466309
109CDK11A0.60125668
110LRRK20.60009261
111CDK20.59447491
112NTRK30.59300417
113LIMK10.59059615
114FER0.57569649
115MAP2K40.57333254
116PTK2B0.56391315
117STK390.56206038
118PAK40.56180434
119GRK10.55582984
120PRKCI0.55122493
121MTOR0.54832583
122LATS10.54695369
123CDK180.54182558
124RPS6KA10.53422264
125CDK150.52999642
126MARK30.52776519
127ZAK0.52098957
128BMX0.51079198
129CSNK1E0.48391472
130STK110.48388330
131CDK140.47727565
132CDC42BPA0.47725539
133CDK10.47724007
134PRKD30.47385514
135CSNK1A1L0.46302320
136RPS6KL10.45661269
137RPS6KC10.45661269
138EPHB10.45605872
139CDK40.45337951
140MAP3K70.44355941
141PASK0.43149635
142MAPKAPK20.42921390
143CSNK1G10.42812594
144ADRBK10.42633551
145TGFBR10.42568711
146DYRK1A0.42193689
147FGFR20.41736607
148MAPKAPK50.41558689
149CSNK1G30.41100235
150PRKDC0.40812304
151RPS6KA60.39099743
152GSK3A0.38494079
153MAPK90.38148623
154BRAF0.38140168
155AKT20.36342444
156MAP3K60.36127144
157SGK2230.35478136
158PRKCE0.33925345
159CSF1R0.33594756
160INSRR0.32485026

Predicted pathways (KEGG)

RankGene SetZ-score
1Drug metabolism - cytochrome P450_Homo sapiens_hsa009824.21795700
2Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009804.21589587
3Mismatch repair_Homo sapiens_hsa034303.75302016
4Chemical carcinogenesis_Homo sapiens_hsa052043.56714382
5DNA replication_Homo sapiens_hsa030303.46533645
6Pentose and glucuronate interconversions_Homo sapiens_hsa000403.45661517
7Glutathione metabolism_Homo sapiens_hsa004802.72852244
8mRNA surveillance pathway_Homo sapiens_hsa030152.45307860
9Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005342.30957442
10Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.30205708
11Base excision repair_Homo sapiens_hsa034102.22573477
12One carbon pool by folate_Homo sapiens_hsa006702.19225593
13Sulfur metabolism_Homo sapiens_hsa009202.14692604
14Phototransduction_Homo sapiens_hsa047442.12559898
15Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045502.06798101
16Protein export_Homo sapiens_hsa030602.03641048
17RNA transport_Homo sapiens_hsa030131.99601179
18Spliceosome_Homo sapiens_hsa030401.98320422
19Nucleotide excision repair_Homo sapiens_hsa034201.94022913
20Drug metabolism - other enzymes_Homo sapiens_hsa009831.85814112
21Sulfur relay system_Homo sapiens_hsa041221.83384357
22Hippo signaling pathway_Homo sapiens_hsa043901.78591690
23Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.69028390
24Cell cycle_Homo sapiens_hsa041101.61903996
25Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.60719096
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.51351775
27Basal cell carcinoma_Homo sapiens_hsa052171.48241075
28Steroid hormone biosynthesis_Homo sapiens_hsa001401.47034344
29TGF-beta signaling pathway_Homo sapiens_hsa043501.42071945
30Butanoate metabolism_Homo sapiens_hsa006501.41033831
31Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.38643117
32Homologous recombination_Homo sapiens_hsa034401.36169273
33Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.33484706
34Fanconi anemia pathway_Homo sapiens_hsa034601.28949403
35Tight junction_Homo sapiens_hsa045301.27703766
36Non-homologous end-joining_Homo sapiens_hsa034501.26400031
37Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.17697682
38RNA degradation_Homo sapiens_hsa030181.15438813
39Huntingtons disease_Homo sapiens_hsa050161.13409169
40Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.07698179
41Collecting duct acid secretion_Homo sapiens_hsa049661.06893046
42Retinol metabolism_Homo sapiens_hsa008301.06395446
43Transcriptional misregulation in cancer_Homo sapiens_hsa052021.02789768
44Lysine degradation_Homo sapiens_hsa003101.01614017
45Adherens junction_Homo sapiens_hsa045200.99843167
46Hedgehog signaling pathway_Homo sapiens_hsa043400.92001137
47Pyrimidine metabolism_Homo sapiens_hsa002400.91539887
48Fatty acid biosynthesis_Homo sapiens_hsa000610.90147423
49Nicotine addiction_Homo sapiens_hsa050330.90144156
50beta-Alanine metabolism_Homo sapiens_hsa004100.88467856
51HTLV-I infection_Homo sapiens_hsa051660.86155146
52Notch signaling pathway_Homo sapiens_hsa043300.85618409
53Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.82895991
54Propanoate metabolism_Homo sapiens_hsa006400.81957912
55p53 signaling pathway_Homo sapiens_hsa041150.81536695
56Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.79721366
57Histidine metabolism_Homo sapiens_hsa003400.79486912
58Linoleic acid metabolism_Homo sapiens_hsa005910.78581656
59Prion diseases_Homo sapiens_hsa050200.76264195
60Selenocompound metabolism_Homo sapiens_hsa004500.74747693
61FoxO signaling pathway_Homo sapiens_hsa040680.74020486
62Phenylalanine metabolism_Homo sapiens_hsa003600.73483901
63Oocyte meiosis_Homo sapiens_hsa041140.71822297
64MicroRNAs in cancer_Homo sapiens_hsa052060.71066155
65Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.70586469
66Dopaminergic synapse_Homo sapiens_hsa047280.70337580
67Cyanoamino acid metabolism_Homo sapiens_hsa004600.68416642
68Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.68158717
69Regulation of autophagy_Homo sapiens_hsa041400.68132043
70Wnt signaling pathway_Homo sapiens_hsa043100.67054716
71Cardiac muscle contraction_Homo sapiens_hsa042600.66202214
72Cocaine addiction_Homo sapiens_hsa050300.64925489
73Thyroid hormone synthesis_Homo sapiens_hsa049180.63536089
74Tyrosine metabolism_Homo sapiens_hsa003500.61103654
75Basal transcription factors_Homo sapiens_hsa030220.60905541
76Olfactory transduction_Homo sapiens_hsa047400.60485024
77Steroid biosynthesis_Homo sapiens_hsa001000.60226441
78Morphine addiction_Homo sapiens_hsa050320.59885260
79Gastric acid secretion_Homo sapiens_hsa049710.59181821
80Arginine and proline metabolism_Homo sapiens_hsa003300.57310879
81Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.56407614
82ECM-receptor interaction_Homo sapiens_hsa045120.54922696
83Graft-versus-host disease_Homo sapiens_hsa053320.54715554
84Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.54344994
85Purine metabolism_Homo sapiens_hsa002300.52340811
86GnRH signaling pathway_Homo sapiens_hsa049120.52047672
87Protein digestion and absorption_Homo sapiens_hsa049740.51265957
88Prostate cancer_Homo sapiens_hsa052150.51149204
89Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.50451334
90Systemic lupus erythematosus_Homo sapiens_hsa053220.49662820
91Pyruvate metabolism_Homo sapiens_hsa006200.48632448
92Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.48099198
93Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.46979702
94TNF signaling pathway_Homo sapiens_hsa046680.44898752
95Small cell lung cancer_Homo sapiens_hsa052220.44822434
96Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.44723481
97Parkinsons disease_Homo sapiens_hsa050120.44488853
98Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.42617306
99Galactose metabolism_Homo sapiens_hsa000520.41999704
100Melanoma_Homo sapiens_hsa052180.41174451
101Glycerolipid metabolism_Homo sapiens_hsa005610.41130726
102Vibrio cholerae infection_Homo sapiens_hsa051100.40807582
103Arachidonic acid metabolism_Homo sapiens_hsa005900.40132017
104Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.39774913
105Cysteine and methionine metabolism_Homo sapiens_hsa002700.39773957
106Amphetamine addiction_Homo sapiens_hsa050310.39637397
107Starch and sucrose metabolism_Homo sapiens_hsa005000.39617870
108ABC transporters_Homo sapiens_hsa020100.38876298
109Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.37988172
110Metabolic pathways_Homo sapiens_hsa011000.37864515
111Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.37347421
112Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.37172180
113Mineral absorption_Homo sapiens_hsa049780.36557417
114Alcoholism_Homo sapiens_hsa050340.35643599
115Fatty acid degradation_Homo sapiens_hsa000710.35585372
116PI3K-Akt signaling pathway_Homo sapiens_hsa041510.35151152
117Taste transduction_Homo sapiens_hsa047420.34218091
118Longevity regulating pathway - mammal_Homo sapiens_hsa042110.34217440
119Pertussis_Homo sapiens_hsa051330.34169911
120Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.34131077
121NOD-like receptor signaling pathway_Homo sapiens_hsa046210.34009127
122AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.32235747
123Melanogenesis_Homo sapiens_hsa049160.32194388
124Proteoglycans in cancer_Homo sapiens_hsa052050.31730472
125Salmonella infection_Homo sapiens_hsa051320.31612435
126Herpes simplex infection_Homo sapiens_hsa051680.30507602
127African trypanosomiasis_Homo sapiens_hsa051430.29994855
128Circadian rhythm_Homo sapiens_hsa047100.29470365
129Thyroid hormone signaling pathway_Homo sapiens_hsa049190.29213544
130Thyroid cancer_Homo sapiens_hsa052160.29071126
131Ribosome_Homo sapiens_hsa030100.28637101
132Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.26683730
133Viral carcinogenesis_Homo sapiens_hsa052030.25183877
134Pathways in cancer_Homo sapiens_hsa052000.24409848
135Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.23471020
136Insulin resistance_Homo sapiens_hsa049310.22675925
137MAPK signaling pathway_Homo sapiens_hsa040100.22447849
138Leukocyte transendothelial migration_Homo sapiens_hsa046700.22328968
139Prolactin signaling pathway_Homo sapiens_hsa049170.22086860
140Rheumatoid arthritis_Homo sapiens_hsa053230.22073661
141Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.21596029
142Axon guidance_Homo sapiens_hsa043600.20390865

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