DMRTA1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.86302621
2positive regulation of male gonad development (GO:2000020)5.56578140
3cilium movement (GO:0003341)5.53655741
4epithelial cilium movement (GO:0003351)5.46810655
5regulation of male gonad development (GO:2000018)5.35309095
6daunorubicin metabolic process (GO:0044597)5.29975071
7polyketide metabolic process (GO:0030638)5.29975071
8doxorubicin metabolic process (GO:0044598)5.29975071
9axonemal dynein complex assembly (GO:0070286)4.63390321
10positive regulation of cellular amide metabolic process (GO:0034250)4.43514733
11axoneme assembly (GO:0035082)4.10569976
12regulation of activation of Janus kinase activity (GO:0010533)4.09198604
13sex determination (GO:0007530)4.01029400
14estrogen biosynthetic process (GO:0006703)3.99028214
15ribosomal small subunit assembly (GO:0000028)3.90826341
16gonadal mesoderm development (GO:0007506)3.90590652
17positive regulation of meiosis (GO:0045836)3.66237739
18viral transcription (GO:0019083)3.61966577
19nucleotide transmembrane transport (GO:1901679)3.61267551
20detection of molecule of bacterial origin (GO:0032490)3.58787911
21detection of bacterium (GO:0016045)3.56943142
22translational termination (GO:0006415)3.56928177
23retinal ganglion cell axon guidance (GO:0031290)3.47725682
24superoxide anion generation (GO:0042554)3.45942989
25female gonad development (GO:0008585)3.45390350
26regulation of cilium movement (GO:0003352)3.45164213
27epoxygenase P450 pathway (GO:0019373)3.42861876
28negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.39569251
29negative regulation of DNA-templated transcription, elongation (GO:0032785)3.39569251
30paraxial mesoderm development (GO:0048339)3.38797040
31oxidative demethylation (GO:0070989)3.36814954
32detection of other organism (GO:0098543)3.36363304
33positive regulation of meiotic cell cycle (GO:0051446)3.30406316
34neuron fate determination (GO:0048664)3.29518837
35exogenous drug catabolic process (GO:0042738)3.29509130
36chromatin remodeling at centromere (GO:0031055)3.28451494
37poly(A)+ mRNA export from nucleus (GO:0016973)3.27431669
38motile cilium assembly (GO:0044458)3.27247338
39neuron projection extension involved in neuron projection guidance (GO:1902284)3.23740200
40axon extension involved in axon guidance (GO:0048846)3.23740200
41cilium morphogenesis (GO:0060271)3.23463276
42detection of external biotic stimulus (GO:0098581)3.19442646
43nucleotide-binding oligomerization domain containing signaling pathway (GO:0070423)3.18468878
44auditory receptor cell stereocilium organization (GO:0060088)3.18401816
45SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.16857068
46cotranslational protein targeting to membrane (GO:0006613)3.16649936
47omega-hydroxylase P450 pathway (GO:0097267)3.16095039
48pyrimidine nucleobase catabolic process (GO:0006208)3.15483346
49regulation of meiosis I (GO:0060631)3.14112986
50regulation of dendritic cell antigen processing and presentation (GO:0002604)3.13116580
51behavioral response to nicotine (GO:0035095)3.12850005
52viral protein processing (GO:0019082)3.11252388
53L-amino acid import (GO:0043092)3.10342318
54male sex determination (GO:0030238)3.08373195
55regulation of cell proliferation involved in kidney development (GO:1901722)3.08194008
56protein targeting to ER (GO:0045047)3.07579867
57piRNA metabolic process (GO:0034587)3.07426021
58nucleobase catabolic process (GO:0046113)3.05853842
59olfactory bulb development (GO:0021772)3.05327939
60negative regulation of mast cell activation (GO:0033004)3.05182693
61mesonephros development (GO:0001823)3.04151040
62left/right axis specification (GO:0070986)3.04101236
63ventricular system development (GO:0021591)3.02734779
64cell differentiation involved in metanephros development (GO:0072202)3.01625772
65DNA methylation involved in gamete generation (GO:0043046)3.00919346
66inner ear receptor stereocilium organization (GO:0060122)3.00548595
67negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.00239613
68left/right pattern formation (GO:0060972)3.00145972
69cilium organization (GO:0044782)2.97495969
70establishment of protein localization to endoplasmic reticulum (GO:0072599)2.97076280
71limb bud formation (GO:0060174)2.96963519
72aminoglycoside antibiotic metabolic process (GO:0030647)2.96382481
73positive regulation of interleukin-17 production (GO:0032740)2.95521223
74negative regulation of meiosis (GO:0045835)2.92848022
75retinal cone cell development (GO:0046549)2.92245439
76tongue development (GO:0043586)2.91631797
77regulation of gonadotropin secretion (GO:0032276)2.90761219
78sulfate transmembrane transport (GO:1902358)2.90219507
79L-serine metabolic process (GO:0006563)2.89643779
80cell proliferation in forebrain (GO:0021846)2.89407761
81short-term memory (GO:0007614)2.88172644
82DNA strand renaturation (GO:0000733)2.87596682
83CENP-A containing nucleosome assembly (GO:0034080)2.87254040
84somite development (GO:0061053)2.86716060
85cilium assembly (GO:0042384)2.85079400
86sulfate transport (GO:0008272)2.84788053
87protein localization to endoplasmic reticulum (GO:0070972)2.84226760
88translational elongation (GO:0006414)2.84186052
89substrate-independent telencephalic tangential migration (GO:0021826)2.83252014
90substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.83252014
91glomerulus development (GO:0032835)2.81237459
92detection of biotic stimulus (GO:0009595)2.81007032
93drug catabolic process (GO:0042737)2.80278317
94androgen biosynthetic process (GO:0006702)2.79600954
95retinal rod cell development (GO:0046548)2.78686822
96dentate gyrus development (GO:0021542)2.78558169
97limb development (GO:0060173)2.78028250
98appendage development (GO:0048736)2.78028250
99negative regulation of myoblast differentiation (GO:0045662)2.77699928
100regulation of glomerulus development (GO:0090192)2.76859729
101establishment of protein localization to mitochondrial membrane (GO:0090151)2.76068191
102cellular response to gamma radiation (GO:0071480)2.75360249
103smoothened signaling pathway (GO:0007224)2.75021215
104dorsal/ventral pattern formation (GO:0009953)2.73866951
105regulation of non-canonical Wnt signaling pathway (GO:2000050)2.73553531
106positive regulation of uterine smooth muscle contraction (GO:0070474)2.73133437
107prostate gland growth (GO:0060736)2.72926195
108lateral ventricle development (GO:0021670)2.71992552
109cellular protein complex disassembly (GO:0043624)2.71787983
110negative regulation of keratinocyte proliferation (GO:0010839)2.70671841
111startle response (GO:0001964)2.69929704
112G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.69300531
113histone H2A monoubiquitination (GO:0035518)2.69069682
114neuronal stem cell maintenance (GO:0097150)2.68046316
115microglial cell activation (GO:0001774)2.67648225
116serine family amino acid catabolic process (GO:0009071)2.66966045
117nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.66640561
118glomerular basement membrane development (GO:0032836)2.61197796
119determination of left/right symmetry (GO:0007368)2.60908401
120kinetochore assembly (GO:0051382)2.60876780
121viral life cycle (GO:0019058)2.59981193
122mesenchymal cell differentiation involved in renal system development (GO:2001012)2.59226005
123mesenchymal cell differentiation involved in kidney development (GO:0072161)2.59226005
124regulation of chemokine-mediated signaling pathway (GO:0070099)2.58326476
125negative regulation of synaptic transmission, GABAergic (GO:0032229)2.56909753
126response to nitrosative stress (GO:0051409)2.56767254
127metanephric mesenchyme development (GO:0072075)2.55714801
128fatty acid elongation (GO:0030497)2.55003620
129DNA integration (GO:0015074)2.54624809
130translational initiation (GO:0006413)2.54086602
131positive regulation of protein homodimerization activity (GO:0090073)2.53998629
132determination of bilateral symmetry (GO:0009855)2.53125927
133cell proliferation involved in kidney development (GO:0072111)2.52078997
134extracellular regulation of signal transduction (GO:1900115)2.51674647
135extracellular negative regulation of signal transduction (GO:1900116)2.51674647
136regulation of interleukin-8 secretion (GO:2000482)2.50825899
137phenylpropanoid metabolic process (GO:0009698)2.50688355
138male meiosis (GO:0007140)2.50613772
139activated T cell proliferation (GO:0050798)2.50520679
140cytoplasmic pattern recognition receptor signaling pathway (GO:0002753)2.49830639
141import into cell (GO:0098657)2.49780947
142positive regulation of gastrulation (GO:2000543)2.48799115
143purine ribonucleotide transport (GO:0015868)2.47906002
144polyol transport (GO:0015791)2.47886598
145kinetochore organization (GO:0051383)2.46639450
146positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)2.46530471
147axonal fasciculation (GO:0007413)2.46498185
148GTP biosynthetic process (GO:0006183)2.46278527
149specification of symmetry (GO:0009799)2.46191570
150replicative senescence (GO:0090399)2.45880518
151positive regulation of NIK/NF-kappaB signaling (GO:1901224)2.45869914
152establishment of integrated proviral latency (GO:0075713)2.44948881
153regulation of mesenchymal cell apoptotic process (GO:2001053)2.44540579
154protein complex disassembly (GO:0043241)2.44431801
155response to pheromone (GO:0019236)2.43473683
156cilium or flagellum-dependent cell motility (GO:0001539)2.43196763
157long-chain fatty acid biosynthetic process (GO:0042759)2.42975249
158negative chemotaxis (GO:0050919)2.42962662
159DNA ligation (GO:0006266)2.42889212
160regulation of female gonad development (GO:2000194)2.42787488
161protein localization to cilium (GO:0061512)2.42086160
162photoreceptor cell maintenance (GO:0045494)2.40916797
163nonmotile primary cilium assembly (GO:0035058)2.40858732
164chaperone-mediated protein transport (GO:0072321)2.40089877
165cellular anion homeostasis (GO:0030002)2.39549460
166ribosomal small subunit biogenesis (GO:0042274)2.39174498
167meiotic chromosome segregation (GO:0045132)2.39107462
168microtubule severing (GO:0051013)2.38740285
169macromolecular complex disassembly (GO:0032984)2.37156591
170nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway (GO:0035872)2.36719932
171androgen metabolic process (GO:0008209)2.36570407
172mitochondrial respiratory chain complex I assembly (GO:0032981)2.36100758
173NADH dehydrogenase complex assembly (GO:0010257)2.36100758
174mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.36100758
175intraciliary transport (GO:0042073)2.34863310
176regulation of glucokinase activity (GO:0033131)2.34390203
177regulation of hexokinase activity (GO:1903299)2.34390203
178dorsal/ventral neural tube patterning (GO:0021904)2.34160406
179T-helper cell differentiation (GO:0042093)2.33971435
180CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.33971435
181positive regulation of protein sumoylation (GO:0033235)2.33344733
182regulation of NIK/NF-kappaB signaling (GO:1901222)2.32992164
183regulation of timing of cell differentiation (GO:0048505)2.32971898
184maturation of SSU-rRNA (GO:0030490)2.32926795
185phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.32789680
186protein complex biogenesis (GO:0070271)2.32351909
187regulation of mesoderm development (GO:2000380)2.32338186
188cell differentiation involved in kidney development (GO:0061005)2.32322862
189DNA replication-independent nucleosome assembly (GO:0006336)2.31453028
190DNA replication-independent nucleosome organization (GO:0034724)2.31453028
191negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.31448119
192regulation of development, heterochronic (GO:0040034)2.31057072
193cell proliferation involved in metanephros development (GO:0072203)2.31030632
194cyclic nucleotide catabolic process (GO:0009214)2.30949768
195kidney morphogenesis (GO:0060993)2.30768734

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human4.00703660
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.66853802
3RBPJ_22232070_ChIP-Seq_NCS_Mouse3.38214579
4ZFP57_27257070_Chip-Seq_ESCs_Mouse2.65996079
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.53233374
6ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.43731701
7PCGF2_27294783_Chip-Seq_ESCs_Mouse2.41630537
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.39923869
9TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.39353488
10GABP_17652178_ChIP-ChIP_JURKAT_Human2.38386487
11TAF15_26573619_Chip-Seq_HEK293_Human2.24372802
12ZNF274_21170338_ChIP-Seq_K562_Hela2.19902017
13NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.16348442
14CBX2_27304074_Chip-Seq_ESCs_Mouse2.14611620
15FLI1_27457419_Chip-Seq_LIVER_Mouse2.14008179
16CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.11365705
17KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.10482197
18POU3F2_20337985_ChIP-ChIP_501MEL_Human2.04843400
19SUZ12_27294783_Chip-Seq_NPCs_Mouse2.03724652
20PCGF2_27294783_Chip-Seq_NPCs_Mouse1.98016803
21HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.95265454
22NFE2_27457419_Chip-Seq_LIVER_Mouse1.91271870
23PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.88395272
24FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.86713440
25P300_19829295_ChIP-Seq_ESCs_Human1.86105719
26* EED_16625203_ChIP-ChIP_MESCs_Mouse1.83563648
27STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.83344000
28* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.82989354
29SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.81919686
30EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.81791639
31SMAD_19615063_ChIP-ChIP_OVARY_Human1.79927804
32EZH2_27294783_Chip-Seq_NPCs_Mouse1.79867261
33BP1_19119308_ChIP-ChIP_Hs578T_Human1.79065000
34E2F1_18555785_Chip-Seq_ESCs_Mouse1.77999439
35NANOG_18555785_Chip-Seq_ESCs_Mouse1.75020699
36EZH2_22144423_ChIP-Seq_EOC_Human1.74851000
37STAT3_18555785_Chip-Seq_ESCs_Mouse1.73559526
38* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.72150390
39MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.71691580
40IGF1R_20145208_ChIP-Seq_DFB_Human1.71489731
41SUZ12_18555785_Chip-Seq_ESCs_Mouse1.70707311
42P53_22387025_ChIP-Seq_ESCs_Mouse1.69055358
43* RNF2_27304074_Chip-Seq_NSC_Mouse1.68600488
44* PIAS1_25552417_ChIP-Seq_VCAP_Human1.68380400
45HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.65107537
46ELK1_19687146_ChIP-ChIP_HELA_Human1.64426567
47FUS_26573619_Chip-Seq_HEK293_Human1.63208769
48* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.60431439
49CMYC_18555785_Chip-Seq_ESCs_Mouse1.59941324
50MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.59050870
51ER_23166858_ChIP-Seq_MCF-7_Human1.58504986
52* EWS_26573619_Chip-Seq_HEK293_Human1.58320068
53VDR_22108803_ChIP-Seq_LS180_Human1.57606577
54EST1_17652178_ChIP-ChIP_JURKAT_Human1.57497395
55* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.57159536
56SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.56907506
57* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.56052091
58* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.55440683
59* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.55351258
60NMYC_18555785_Chip-Seq_ESCs_Mouse1.55275522
61EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.54323322
62CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.53843064
63CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.53529583
64POU5F1_16153702_ChIP-ChIP_HESCs_Human1.52737172
65P300_18555785_Chip-Seq_ESCs_Mouse1.52291127
66SOX2_16153702_ChIP-ChIP_HESCs_Human1.52051761
67EZH2_27304074_Chip-Seq_ESCs_Mouse1.51282429
68RUNX1_27457419_Chip-Seq_LIVER_Mouse1.51194145
69SMAD4_21799915_ChIP-Seq_A2780_Human1.51162730
70HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.50217369
71* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.48425599
72SOX2_18555785_ChIP-Seq_MESCs_Mouse1.48366150
73MYC_18940864_ChIP-ChIP_HL60_Human1.48314086
74POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.47894523
75TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.47894523
76* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.45459221
77IRF1_19129219_ChIP-ChIP_H3396_Human1.45436134
78OCT4_18555785_Chip-Seq_ESCs_Mouse1.42900794
79SOX2_18555785_Chip-Seq_ESCs_Mouse1.41839223
80NANOG_16153702_ChIP-ChIP_HESCs_Human1.41723617
81SMAD3_21741376_ChIP-Seq_EPCs_Human1.41418357
82ZFX_18555785_Chip-Seq_ESCs_Mouse1.41039562
83OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.39273831
84WT1_19549856_ChIP-ChIP_CCG9911_Human1.39143998
85* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.38283366
86PU1_27457419_Chip-Seq_LIVER_Mouse1.37002946
87STAT3_23295773_ChIP-Seq_U87_Human1.36514760
88ESRRB_18555785_Chip-Seq_ESCs_Mouse1.32946507
89VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.32221047
90TP53_18474530_ChIP-ChIP_U2OS_Human1.31641139
91SMAD1_18555785_Chip-Seq_ESCs_Mouse1.31609533
92KLF4_18555785_Chip-Seq_ESCs_Mouse1.29291201
93TCF4_23295773_ChIP-Seq_U87_Human1.28857440
94* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.28692140
95ZNF217_24962896_ChIP-Seq_MCF-7_Human1.28314344
96TOP2B_26459242_ChIP-Seq_MCF-7_Human1.27258110
97RNF2_18974828_ChIP-Seq_MESCs_Mouse1.26706333
98EZH2_18974828_ChIP-Seq_MESCs_Mouse1.26706333
99BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.25768850
100E2F4_17652178_ChIP-ChIP_JURKAT_Human1.24176547
101GATA1_26923725_Chip-Seq_HPCs_Mouse1.23590030
102* RNF2_27304074_Chip-Seq_ESCs_Mouse1.23572572
103* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.23326539
104TP63_19390658_ChIP-ChIP_HaCaT_Human1.23000433
105UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.22464856
106* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.21374168
107MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.21111049
108* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.20149888
109* CBP_20019798_ChIP-Seq_JUKART_Human1.20149888
110TAL1_26923725_Chip-Seq_HPCs_Mouse1.19254520
111NR3C1_21868756_ChIP-Seq_MCF10A_Human1.18098964
112* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17967929
113MYC_18555785_ChIP-Seq_MESCs_Mouse1.17638114
114JARID2_20075857_ChIP-Seq_MESCs_Mouse1.16064109
115TP53_16413492_ChIP-PET_HCT116_Human1.15931417
116CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.15854826
117CTCF_18555785_Chip-Seq_ESCs_Mouse1.15552091
118CRX_20693478_ChIP-Seq_RETINA_Mouse1.15360922
119SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.15124767
120EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.14536465
121KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.14216358
122PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.13242658
123CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.12752544
124CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.11519096
125* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.11464142
126GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.09262766
127OCT4_21477851_ChIP-Seq_ESCs_Mouse1.08483865
128RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07607686
129NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.07385566
130SALL1_21062744_ChIP-ChIP_HESCs_Human1.06597609
131* RUNX2_22187159_ChIP-Seq_PCA_Human1.06308996
132LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06092942
133POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.05765943
134KLF5_20875108_ChIP-Seq_MESCs_Mouse1.05681013
135TCF4_22108803_ChIP-Seq_LS180_Human1.01795765
136SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.01283659
137CREB1_15753290_ChIP-ChIP_HEK293T_Human0.97595612
138* AR_25329375_ChIP-Seq_VCAP_Human0.96783741
139TBX3_20139965_ChIP-Seq_ESCs_Mouse0.96255446
140TBX3_20139965_ChIP-Seq_MESCs_Mouse0.95156102
141PADI4_21655091_ChIP-ChIP_MCF-7_Human0.95105093
142ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.93546073
143TTF2_22483619_ChIP-Seq_HELA_Human0.93232992
144RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.92864725
145TP53_22573176_ChIP-Seq_HFKS_Human0.91226438
146BCAT_22108803_ChIP-Seq_LS180_Human0.90366761
147SOX2_19829295_ChIP-Seq_ESCs_Human0.87872583
148NANOG_19829295_ChIP-Seq_ESCs_Human0.87872583
149* FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.87493339
150KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.86797853
151POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.86161697
152SOX9_26525672_Chip-Seq_HEART_Mouse0.83725972
153KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.83631505
154TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.83408012
155TCF3_18692474_ChIP-Seq_MESCs_Mouse0.82841782
156* ISL1_27105846_Chip-Seq_CPCs_Mouse0.80878612

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005171_absent_coat_pigmentation5.09744742
2MP0010030_abnormal_orbit_morphology4.16796978
3MP0002653_abnormal_ependyma_morphology3.70555255
4MP0005377_hearing/vestibular/ear_phenot3.49335637
5MP0003878_abnormal_ear_physiology3.49335637
6MP0008995_early_reproductive_senescence3.31807488
7MP0003122_maternal_imprinting3.11199427
8MP0001188_hyperpigmentation3.07118197
9MP0008877_abnormal_DNA_methylation2.87178970
10MP0001293_anophthalmia2.83253802
11MP0000566_synostosis2.75467585
12MP0002102_abnormal_ear_morphology2.74639396
13MP0006292_abnormal_olfactory_placode2.62855155
14MP0003787_abnormal_imprinting2.45708273
15MP0009697_abnormal_copulation2.44900633
16MP0000678_abnormal_parathyroid_gland2.44596039
17MP0005645_abnormal_hypothalamus_physiol2.22325229
18MP0009379_abnormal_foot_pigmentation2.20493416
19MP0004133_heterotaxia2.15803922
20MP0005503_abnormal_tendon_morphology2.15111266
21MP0005646_abnormal_pituitary_gland2.11470485
22MP0002938_white_spotting2.05629536
23MP0004742_abnormal_vestibular_system1.97903553
24MP0002132_abnormal_respiratory_system1.97726990
25MP0003941_abnormal_skin_development1.96567063
26MP0003937_abnormal_limbs/digits/tail_de1.81915888
27MP0002234_abnormal_pharynx_morphology1.81769655
28MP0000372_irregular_coat_pigmentation1.76704723
29MP0003011_delayed_dark_adaptation1.74889831
30MP0003123_paternal_imprinting1.74199126
31MP0004134_abnormal_chest_morphology1.64948298
32MP0002277_abnormal_respiratory_mucosa1.61838781
33MP0003786_premature_aging1.60528312
34MP0003195_calcinosis1.59701937
35MP0004782_abnormal_surfactant_physiolog1.59311040
36MP0008875_abnormal_xenobiotic_pharmacok1.55850279
37MP0008789_abnormal_olfactory_epithelium1.54207336
38MP0001286_abnormal_eye_development1.53258978
39MP0005409_darkened_coat_color1.52098014
40MP0003136_yellow_coat_color1.48765208
41MP0001984_abnormal_olfaction1.47268645
42MP0005647_abnormal_sex_gland1.47186712
43MP0002697_abnormal_eye_size1.46095670
44MP0003690_abnormal_glial_cell1.44980265
45MP0002736_abnormal_nociception_after1.42540588
46MP0006072_abnormal_retinal_apoptosis1.41928671
47MP0005253_abnormal_eye_physiology1.38357885
48MP0000681_abnormal_thyroid_gland1.35940227
49MP0002876_abnormal_thyroid_physiology1.35328074
50MP0005391_vision/eye_phenotype1.35016012
51MP0004381_abnormal_hair_follicle1.34623745
52MP0001485_abnormal_pinna_reflex1.33853841
53MP0003879_abnormal_hair_cell1.32677208
54MP0009053_abnormal_anal_canal1.30826509
55MP0003755_abnormal_palate_morphology1.29406099
56MP0005310_abnormal_salivary_gland1.29164492
57MP0000026_abnormal_inner_ear1.29132079
58MP0002092_abnormal_eye_morphology1.26813762
59MP0002210_abnormal_sex_determination1.24595002
60MP0003119_abnormal_digestive_system1.24462091
61MP0005195_abnormal_posterior_eye1.24228653
62MP0005499_abnormal_olfactory_system1.24105947
63MP0005394_taste/olfaction_phenotype1.24105947
64MP0001486_abnormal_startle_reflex1.19488188
65MP0005410_abnormal_fertilization1.19240325
66MP0008057_abnormal_DNA_replication1.19229688
67MP0002148_abnormal_hypersensitivity_rea1.16490972
68MP0003861_abnormal_nervous_system1.15432690
69MP0001919_abnormal_reproductive_system1.13862525
70MP0001324_abnormal_eye_pigmentation1.13728403
71MP0002928_abnormal_bile_duct1.13680618
72MP0008058_abnormal_DNA_repair1.13588807
73MP0008260_abnormal_autophagy1.12842911
74MP0003938_abnormal_ear_development1.11521698
75MP0005085_abnormal_gallbladder_physiolo1.09603100
76MP0005389_reproductive_system_phenotype1.09365599
77MP0000428_abnormal_craniofacial_morphol1.07659749
78MP0008007_abnormal_cellular_replicative1.07186959
79MP0005367_renal/urinary_system_phenotyp1.07135216
80MP0000516_abnormal_urinary_system1.07135216
81* MP0001119_abnormal_female_reproductive1.06923333
82MP0000631_abnormal_neuroendocrine_gland1.06515055
83MP0010386_abnormal_urinary_bladder1.05445071
84MP0009278_abnormal_bone_marrow1.01515568
85MP0004142_abnormal_muscle_tone1.01234665
86MP0001963_abnormal_hearing_physiology1.00500735
87MP0003121_genomic_imprinting0.99100666
88MP0002160_abnormal_reproductive_system0.98859060
89MP0001986_abnormal_taste_sensitivity0.98367379
90MP0002752_abnormal_somatic_nervous0.97317353
91MP0009764_decreased_sensitivity_to0.96986919
92MP0002751_abnormal_autonomic_nervous0.96887596
93MP0002163_abnormal_gland_morphology0.96761350
94MP0003698_abnormal_male_reproductive0.93370808
95MP0000778_abnormal_nervous_system0.92782491
96MP0001177_atelectasis0.92478297
97MP0001299_abnormal_eye_distance/0.92277734
98MP0000569_abnormal_digit_pigmentation0.91674702
99MP0000383_abnormal_hair_follicle0.91471306
100MP0000015_abnormal_ear_pigmentation0.91136342
101MP0003942_abnormal_urinary_system0.91047786
102MP0000647_abnormal_sebaceous_gland0.90946357
103MP0006276_abnormal_autonomic_nervous0.89972202
104MP0005408_hypopigmentation0.89752158
105MP0001529_abnormal_vocalization0.89674144
106MP0003693_abnormal_embryo_hatching0.89055945
107MP0002233_abnormal_nose_morphology0.88943791
108MP0001929_abnormal_gametogenesis0.88579501
109MP0005197_abnormal_uvea_morphology0.88491558
110MP0002084_abnormal_developmental_patter0.88260543
111MP0002116_abnormal_craniofacial_bone0.87901963
112MP0003315_abnormal_perineum_morphology0.87756990
113MP0002111_abnormal_tail_morphology0.87624613
114MP0003890_abnormal_embryonic-extraembry0.85962255
115MP0003283_abnormal_digestive_organ0.85482853
116MP0000049_abnormal_middle_ear0.85036840
117MP0003943_abnormal_hepatobiliary_system0.84251827
118MP0002152_abnormal_brain_morphology0.84245591
119MP0003880_abnormal_central_pattern0.83968095
120MP0002638_abnormal_pupillary_reflex0.83665099
121MP0002085_abnormal_embryonic_tissue0.83292504
122MP0002249_abnormal_larynx_morphology0.82899808
123MP0009765_abnormal_xenobiotic_induced0.82736410
124MP0003935_abnormal_craniofacial_develop0.82651800
125MP0002282_abnormal_trachea_morphology0.82380123
126MP0009250_abnormal_appendicular_skeleto0.82112657
127MP0002009_preneoplasia0.81208465
128MP0001346_abnormal_lacrimal_gland0.80761526
129MP0003718_maternal_effect0.80613837
130MP0000955_abnormal_spinal_cord0.79679479
131MP0001905_abnormal_dopamine_level0.79447323
132MP0000427_abnormal_hair_cycle0.79068620
133MP0004147_increased_porphyrin_level0.78935389
134MP0008004_abnormal_stomach_pH0.78602642
135MP0002184_abnormal_innervation0.77502972
136MP0000432_abnormal_head_morphology0.74743064
137MP0001502_abnormal_circadian_rhythm0.74244087
138* MP0002557_abnormal_social/conspecific_i0.73399862
139MP0010678_abnormal_skin_adnexa0.73349834
140MP0001145_abnormal_male_reproductive0.73241226
141MP0005075_abnormal_melanosome_morpholog0.73228910
142MP0009785_altered_susceptibility_to0.72351826
143MP0003252_abnormal_bile_duct0.72279056
144MP0009384_cardiac_valve_regurgitation0.70923845
145MP0002108_abnormal_muscle_morphology0.70856990
146MP0000534_abnormal_ureter_morphology0.70352105
147MP0001186_pigmentation_phenotype0.70329695
148MP0004957_abnormal_blastocyst_morpholog0.70302261
149MP0005551_abnormal_eye_electrophysiolog0.69786029
150MP0002572_abnormal_emotion/affect_behav0.68798534
151MP0008932_abnormal_embryonic_tissue0.68392802
152MP0005248_abnormal_Harderian_gland0.68381780
153MP0003385_abnormal_body_wall0.68307393
154* MP0000653_abnormal_sex_gland0.67979075
155MP0005167_abnormal_blood-brain_barrier0.67082722
156MP0002109_abnormal_limb_morphology0.65769014
157MP0005365_abnormal_bile_salt0.64651586

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of incisor morphology (HP:0011063)4.98908625
2Increased IgM level (HP:0003496)4.43764428
3Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.34442370
4Abnormal respiratory motile cilium physiology (HP:0012261)3.99756332
5Male pseudohermaphroditism (HP:0000037)3.59656609
6Thick nail (HP:0001805)3.38589537
7True hermaphroditism (HP:0010459)3.36870982
8Chromosomal breakage induced by crosslinking agents (HP:0003221)3.27292172
9Conical tooth (HP:0000698)3.27161102
10Rhinitis (HP:0012384)3.22207518
11Anophthalmia (HP:0000528)3.19304015
12Gonadal dysgenesis (HP:0000133)3.14143478
13Abnormality of midbrain morphology (HP:0002418)3.12702302
14Molar tooth sign on MRI (HP:0002419)3.12702302
15Reticulocytopenia (HP:0001896)3.10990843
16Hyperglycinemia (HP:0002154)2.92212416
17Absent rod-and cone-mediated responses on ERG (HP:0007688)2.87038788
18Retrobulbar optic neuritis (HP:0100654)2.86546546
19Optic neuritis (HP:0100653)2.86546546
20Medial flaring of the eyebrow (HP:0010747)2.85920723
21Tubulointerstitial nephritis (HP:0001970)2.84147759
22Supernumerary spleens (HP:0009799)2.82975314
23Hypoplastic left heart (HP:0004383)2.82175626
24Rib fusion (HP:0000902)2.78611391
25Renal cortical cysts (HP:0000803)2.77437457
26Keratitis (HP:0000491)2.74156213
27Ectopic kidney (HP:0000086)2.73669813
28Hypoplasia of the uterus (HP:0000013)2.71244228
29White forelock (HP:0002211)2.70911714
30Congenital primary aphakia (HP:0007707)2.68012239
31Anomalous pulmonary venous return (HP:0010772)2.66906610
32Bifid tongue (HP:0010297)2.66729662
33Patchy hypopigmentation of hair (HP:0011365)2.60809901
34Azoospermia (HP:0000027)2.60535006
35Chromsome breakage (HP:0040012)2.60254659
36Nephrogenic diabetes insipidus (HP:0009806)2.60076614
37Aplasia/Hypoplasia of the tongue (HP:0010295)2.59954522
38Abdominal situs inversus (HP:0003363)2.57624134
39Abnormality of abdominal situs (HP:0011620)2.57624134
40Septo-optic dysplasia (HP:0100842)2.56182994
41Sclerocornea (HP:0000647)2.55787973
42Gait imbalance (HP:0002141)2.55413317
43Supernumerary ribs (HP:0005815)2.55120344
44Chronic hepatic failure (HP:0100626)2.54513629
45Hypoplastic heart (HP:0001961)2.50918217
46Parakeratosis (HP:0001036)2.48646530
47Ridged nail (HP:0001807)2.48108862
48Chronic bronchitis (HP:0004469)2.47180096
49Dynein arm defect of respiratory motile cilia (HP:0012255)2.44598433
50Absent/shortened dynein arms (HP:0200106)2.44598433
51Colon cancer (HP:0003003)2.44427204
52Maternal diabetes (HP:0009800)2.43186177
53Unilateral renal agenesis (HP:0000122)2.42993301
54Absent eyebrow (HP:0002223)2.42347721
55Abnormal rod and cone electroretinograms (HP:0008323)2.41882739
56Congenital malformation of the right heart (HP:0011723)2.39945155
57Double outlet right ventricle (HP:0001719)2.39945155
58Pancreatic fibrosis (HP:0100732)2.38987950
59Postaxial hand polydactyly (HP:0001162)2.34199939
60Poor coordination (HP:0002370)2.33743826
61Abnormality of male internal genitalia (HP:0000022)2.32395793
62Supernumerary bones of the axial skeleton (HP:0009144)2.29757116
63Genital tract atresia (HP:0001827)2.26932781
64Occipital encephalocele (HP:0002085)2.26885422
65Abnormality of the incisor (HP:0000676)2.26309355
66Anencephaly (HP:0002323)2.24564725
67Stenosis of the external auditory canal (HP:0000402)2.23985495
68Abnormality of the pulmonary veins (HP:0011718)2.23885233
69Cystic liver disease (HP:0006706)2.23459346
70Vaginal atresia (HP:0000148)2.22121900
71Abnormality of the renal collecting system (HP:0004742)2.21819062
72Follicular hyperkeratosis (HP:0007502)2.21392054
73Aplasia/hypoplasia of the uterus (HP:0008684)2.20099824
74Abnormality of the renal cortex (HP:0011035)2.19778389
75Postaxial foot polydactyly (HP:0001830)2.17921150
76Growth hormone deficiency (HP:0000824)2.17535823
77Adrenal hypoplasia (HP:0000835)2.16946091
78Absent septum pellucidum (HP:0001331)2.16809293
79Eosinophilia (HP:0001880)2.16079985
80Oligodactyly (hands) (HP:0001180)2.15286167
81Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.14293743
82Gonadotropin excess (HP:0000837)2.13820779
83Abnormality of the labia minora (HP:0012880)2.13788781
84IgA deficiency (HP:0002720)2.13352314
85Acute encephalopathy (HP:0006846)2.12753946
86Male infertility (HP:0003251)2.12619813
87Bile duct proliferation (HP:0001408)2.10346813
88Abnormal biliary tract physiology (HP:0012439)2.10346813
89Broad foot (HP:0001769)2.10241826
90Oligodactyly (HP:0012165)2.06790076
91Prostate neoplasm (HP:0100787)2.06043356
92Duplicated collecting system (HP:0000081)2.05407067
93Abnormal ciliary motility (HP:0012262)2.05316947
94Abnormality of the nasal septum (HP:0000419)2.05262589
95Aplasia/Hypoplasia of the lens (HP:0008063)2.04955179
96Encephalitis (HP:0002383)2.03581576
97Aplasia/Hypoplasia of the tibia (HP:0005772)2.02966612
98Nephronophthisis (HP:0000090)2.00294506
99Hyperglycinuria (HP:0003108)2.00214591
100Specific learning disability (HP:0001328)2.00126081
101Alopecia of scalp (HP:0002293)1.99392595
102Preaxial hand polydactyly (HP:0001177)1.99039446
103Congenital hepatic fibrosis (HP:0002612)1.95445428
104Orchitis (HP:0100796)1.95135944
105Alveolar cell carcinoma (HP:0006519)1.94115267
106Congenital sensorineural hearing impairment (HP:0008527)1.93581965
107Abnormal spermatogenesis (HP:0008669)1.93263080
108Decreased testicular size (HP:0008734)1.92480182
109Hemorrhage of the eye (HP:0011885)1.92296853
110Renal dysplasia (HP:0000110)1.91986284
111Febrile seizures (HP:0002373)1.91458508
112Absent hand (HP:0004050)1.91141158
113Acute necrotizing encephalopathy (HP:0006965)1.89309670
114Dry hair (HP:0011359)1.89301335
115Triphalangeal thumb (HP:0001199)1.88714200
116Abnormality of glycine metabolism (HP:0010895)1.87326054
117Abnormality of serine family amino acid metabolism (HP:0010894)1.87326054
118Abnormality of the renal medulla (HP:0100957)1.87062427
119Transposition of the great arteries (HP:0001669)1.86516515
120Abnormal connection of the cardiac segments (HP:0011545)1.86516515
121Abnormal ventriculo-arterial connection (HP:0011563)1.86516515
122High anterior hairline (HP:0009890)1.85384116
123Median cleft lip (HP:0000161)1.84454143
124Abnormal sex determination (HP:0012244)1.84383430
125Sex reversal (HP:0012245)1.84383430
126Hypergonadotropic hypogonadism (HP:0000815)1.84364050
127Hemivertebrae (HP:0002937)1.84271218
128Hepatoblastoma (HP:0002884)1.83347905
129Astigmatism (HP:0000483)1.83120505
130Holoprosencephaly (HP:0001360)1.82751897
131Abnormal respiratory motile cilium morphology (HP:0005938)1.82653447
132Abnormal respiratory epithelium morphology (HP:0012253)1.82653447
133Nephroblastoma (Wilms tumor) (HP:0002667)1.82607801
134Osteomalacia (HP:0002749)1.82092843
135Bell-shaped thorax (HP:0001591)1.82065422
136Hypothermia (HP:0002045)1.81868320
137Optic nerve hypoplasia (HP:0000609)1.81324894
138Cerebellar dysplasia (HP:0007033)1.80688663
139Disproportionate short-trunk short stature (HP:0003521)1.79997256
140Micropenis (HP:0000054)1.79408736
141Pancreatic cysts (HP:0001737)1.79060936
142Macrocytic anemia (HP:0001972)1.78710250
143Redundant skin (HP:0001582)1.77731643
144Increased hepatocellular lipid droplets (HP:0006565)1.77043505
145Abnormality of the septum pellucidum (HP:0007375)1.76437147
146Tetany (HP:0001281)1.74519430
147Abnormality of cells of the erythroid lineage (HP:0012130)1.73546622
148Aplasia/Hypoplasia of the spleen (HP:0010451)1.71950236
149Granulocytopenia (HP:0001913)1.71377998
150Intestinal atresia (HP:0011100)1.71119204
151Abnormality of the lacrimal duct (HP:0011481)1.71071618
152Embryonal renal neoplasm (HP:0011794)1.70860061
153Pulmonary artery stenosis (HP:0004415)1.69930324
154Stage 5 chronic kidney disease (HP:0003774)1.69844876
155Renal hypoplasia (HP:0000089)1.68658901
156Dandy-Walker malformation (HP:0001305)1.68474224
157Narrow forehead (HP:0000341)1.67721645
158Bronchiectasis (HP:0002110)1.66013218
159Dental crowding (HP:0000678)1.65983967
160Labial hypoplasia (HP:0000066)1.65837803
161Multicystic kidney dysplasia (HP:0000003)1.65749878
162Vitreoretinal degeneration (HP:0000655)1.65409167
163Depressed nasal ridge (HP:0000457)1.64719199
164Lipid accumulation in hepatocytes (HP:0006561)1.64154953
165Fibular hypoplasia (HP:0003038)1.61691096
166Scrotal hypoplasia (HP:0000046)1.61113391
167Aganglionic megacolon (HP:0002251)1.58288444
168Cerebral edema (HP:0002181)1.57823012
169Absent thumb (HP:0009777)1.56301794
170Progressive macrocephaly (HP:0004481)1.56187955

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK3.87862985
2SIK32.96056079
3CASK2.77094212
4IRAK32.68956103
5TRIM282.64570217
6MAP4K22.62952956
7MAP3K42.57097938
8ZAK2.50678652
9TXK2.50230681
10STK38L2.38515452
11ERBB32.28728492
12PRPF4B2.24191445
13IRAK42.09250549
14PNCK2.00592502
15MAPK131.94132353
16INSRR1.85565087
17CDK191.73248339
18MAP3K141.72993031
19TNK21.67418980
20MAP2K71.67409772
21DYRK21.66350537
22EIF2AK11.64091947
23NEK61.63223993
24BCKDK1.62684256
25STK241.62546488
26EIF2AK21.61419386
27BMPR21.60362554
28DYRK31.59890813
29TIE11.59030985
30WNK31.57591398
31BCR1.56684522
32NLK1.51396811
33NUAK11.47419505
34CDK81.46224250
35SGK21.44572817
36NEK11.41321736
37MAP3K101.41138644
38AKT31.40556951
39MAP2K41.40023321
40PASK1.35880858
41IKBKB1.33150447
42MST41.30960512
43PLK21.29128595
44IRAK21.27422199
45EPHB11.25709297
46TRPM71.25322456
47PBK1.23954350
48CDC71.23383394
49MKNK11.22146666
50FGFR21.21824078
51BMPR1B1.19615525
52ADRBK21.14480051
53PIK3CA1.14123203
54SRPK11.13368052
55SGK2231.12262811
56SGK4941.12262811
57STK161.11789106
58YES11.10600382
59MKNK21.10402706
60IRAK11.10154672
61GRK11.09778852
62CDK31.09081642
63PKN11.08857237
64TGFBR11.08125506
65BRD41.06110740
66PLK11.02068995
67STK390.98600723
68ACVR1B0.95029911
69TSSK60.94996551
70CHUK0.94872609
71CSNK1G10.91940325
72DMPK0.91128120
73STK30.88628775
74CLK10.88394641
75PLK40.87934607
76MET0.87873124
77IKBKE0.87591346
78CAMK1G0.87279597
79FRK0.86043074
80NEK20.85095507
81DYRK1B0.83131931
82GRK70.80447602
83VRK20.79325930
84TYRO30.78686772
85TTK0.77853920
86NME10.74664860
87EPHA20.74609664
88AURKB0.70756169
89DYRK1A0.69697864
90EPHA40.69391551
91ICK0.69279907
92TEC0.68160812
93PRKCE0.67566178
94PRKCG0.67052308
95BRSK20.64751587
96WEE10.63774702
97WNK10.63756484
98TAOK20.62469687
99AURKA0.61495059
100MAPK70.61304050
101FGFR10.60974384
102STK40.60705739
103TLK10.60397114
104CSNK1G20.60177287
105RPS6KA40.57242536
106ERBB40.56703334
107MAP3K120.56221221
108SGK30.56015075
109PLK30.55613463
110MYLK0.55205955
111EIF2AK30.53746371
112CSNK1G30.53744937
113LATS10.53284293
114SIK10.53092607
115EPHB20.52942512
116PDK20.52603144
117STK110.52591248
118MAPKAPK50.52328668
119CHEK20.52040465
120FES0.51658640
121CAMK10.49729062
122OXSR10.47437646
123BRSK10.46526739
124ERBB20.45185531
125LRRK20.44898521
126RPS6KB10.44611189
127MUSK0.44173211
128PINK10.43790587
129NTRK20.43468628
130VRK10.42318082
131KSR10.41849736
132MAP3K60.41564474
133OBSCN0.40963427
134ATR0.39996870
135ATM0.39304037
136CSNK2A20.38824542
137CSNK1E0.38821999
138RPS6KB20.38050140
139NEK90.37787716
140AKT20.36632754
141MAP2K60.36385544
142CDK70.36297043
143LYN0.35409544
144MAPK150.34631002
145NTRK30.33249431
146PRKACB0.33158508
147ROCK10.32789918
148PRKCQ0.32748266
149CAMK40.32160685
150BTK0.29480204
151FER0.29346406
152CDC42BPA0.26800181
153CSNK1A1L0.26558908

Predicted pathways (KEGG)

RankGene SetZ-score
1Caffeine metabolism_Homo sapiens_hsa002323.79698313
2Ribosome_Homo sapiens_hsa030103.01172931
3Steroid biosynthesis_Homo sapiens_hsa001002.90208177
4Fatty acid elongation_Homo sapiens_hsa000622.78342924
5Basal transcription factors_Homo sapiens_hsa030222.41880990
6Propanoate metabolism_Homo sapiens_hsa006402.31704595
7Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.25672822
8Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.21189822
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.20594167
10Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051202.07495823
11Rheumatoid arthritis_Homo sapiens_hsa053232.06020125
12Primary bile acid biosynthesis_Homo sapiens_hsa001201.98463598
13NOD-like receptor signaling pathway_Homo sapiens_hsa046211.95873203
14Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.93509873
15Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.91567245
16Non-homologous end-joining_Homo sapiens_hsa034501.89672538
17Graft-versus-host disease_Homo sapiens_hsa053321.89414740
18Butanoate metabolism_Homo sapiens_hsa006501.81275788
19Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.80392590
20Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.80346438
21Oxidative phosphorylation_Homo sapiens_hsa001901.76238037
22Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.69664082
23NF-kappa B signaling pathway_Homo sapiens_hsa040641.67920735
24Huntingtons disease_Homo sapiens_hsa050161.64852513
25Vitamin digestion and absorption_Homo sapiens_hsa049771.62705132
26Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.60173240
27Axon guidance_Homo sapiens_hsa043601.57690281
28Hedgehog signaling pathway_Homo sapiens_hsa043401.57135593
29Ether lipid metabolism_Homo sapiens_hsa005651.55928577
30Toll-like receptor signaling pathway_Homo sapiens_hsa046201.55268386
31Sphingolipid metabolism_Homo sapiens_hsa006001.49768106
32Autoimmune thyroid disease_Homo sapiens_hsa053201.49228312
33Tryptophan metabolism_Homo sapiens_hsa003801.49073422
34Fanconi anemia pathway_Homo sapiens_hsa034601.47597244
35Steroid hormone biosynthesis_Homo sapiens_hsa001401.47421863
36Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.47027689
37Primary immunodeficiency_Homo sapiens_hsa053401.46784138
38Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.46028878
39Parkinsons disease_Homo sapiens_hsa050121.43866725
40Arachidonic acid metabolism_Homo sapiens_hsa005901.42948268
41Cysteine and methionine metabolism_Homo sapiens_hsa002701.41583078
42Fatty acid degradation_Homo sapiens_hsa000711.40251559
43Pentose and glucuronate interconversions_Homo sapiens_hsa000401.38431478
44Mismatch repair_Homo sapiens_hsa034301.34752072
45RNA degradation_Homo sapiens_hsa030181.33309454
46Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.33236765
47Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.32315549
48Collecting duct acid secretion_Homo sapiens_hsa049661.30685206
49Peroxisome_Homo sapiens_hsa041461.28953558
50Maturity onset diabetes of the young_Homo sapiens_hsa049501.27096634
51Pyruvate metabolism_Homo sapiens_hsa006201.26824267
52Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.26695334
53Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.25293115
54Allograft rejection_Homo sapiens_hsa053301.24598025
55beta-Alanine metabolism_Homo sapiens_hsa004101.24037043
56Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.21062958
57Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.19822540
58Phenylalanine metabolism_Homo sapiens_hsa003601.18370551
59SNARE interactions in vesicular transport_Homo sapiens_hsa041301.17612343
60Ovarian steroidogenesis_Homo sapiens_hsa049131.16748181
61Measles_Homo sapiens_hsa051621.16125935
62Protein export_Homo sapiens_hsa030601.14392847
63Homologous recombination_Homo sapiens_hsa034401.13603123
64Arginine and proline metabolism_Homo sapiens_hsa003301.13458435
65Intestinal immune network for IgA production_Homo sapiens_hsa046721.12191109
66Nicotine addiction_Homo sapiens_hsa050331.10598596
67Hippo signaling pathway_Homo sapiens_hsa043901.08587074
68Proteasome_Homo sapiens_hsa030501.05966288
69Herpes simplex infection_Homo sapiens_hsa051681.04841402
70Tyrosine metabolism_Homo sapiens_hsa003501.02669208
71Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.02524208
72Histidine metabolism_Homo sapiens_hsa003401.00262999
73RNA polymerase_Homo sapiens_hsa030201.00209461
74Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.99350929
75TNF signaling pathway_Homo sapiens_hsa046680.97315233
76Prostate cancer_Homo sapiens_hsa052150.95776555
77Influenza A_Homo sapiens_hsa051640.94765307
782-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.94469286
79Biosynthesis of amino acids_Homo sapiens_hsa012300.93750115
80Phagosome_Homo sapiens_hsa041450.92557524
81Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.92388474
82Toxoplasmosis_Homo sapiens_hsa051450.91042925
83RNA transport_Homo sapiens_hsa030130.90371795
84RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.90189544
85Cardiac muscle contraction_Homo sapiens_hsa042600.88944073
86Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.88082109
87Mineral absorption_Homo sapiens_hsa049780.86943398
88Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.86825010
89Base excision repair_Homo sapiens_hsa034100.86744682
90Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.86421678
91Basal cell carcinoma_Homo sapiens_hsa052170.85942687
92Vitamin B6 metabolism_Homo sapiens_hsa007500.85665402
93Serotonergic synapse_Homo sapiens_hsa047260.77860658
94Taste transduction_Homo sapiens_hsa047420.77803459
95TGF-beta signaling pathway_Homo sapiens_hsa043500.77404344
96Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.76222774
97Carbon metabolism_Homo sapiens_hsa012000.76197186
98Arginine biosynthesis_Homo sapiens_hsa002200.75756945
99Metabolic pathways_Homo sapiens_hsa011000.75123374
100Lysine degradation_Homo sapiens_hsa003100.74922222
101Nitrogen metabolism_Homo sapiens_hsa009100.74233450
102Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.73910234
103Folate biosynthesis_Homo sapiens_hsa007900.73885996
104alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.73871717
105Pertussis_Homo sapiens_hsa051330.72771877
106Linoleic acid metabolism_Homo sapiens_hsa005910.71959986
107Alzheimers disease_Homo sapiens_hsa050100.71308034
108Glutathione metabolism_Homo sapiens_hsa004800.70301856
109Spliceosome_Homo sapiens_hsa030400.68407018
110Type I diabetes mellitus_Homo sapiens_hsa049400.66620443
111Adherens junction_Homo sapiens_hsa045200.65998777
112Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.65986235
113Leishmaniasis_Homo sapiens_hsa051400.65885829
114Selenocompound metabolism_Homo sapiens_hsa004500.63468547
115Pyrimidine metabolism_Homo sapiens_hsa002400.62501554
116Retinol metabolism_Homo sapiens_hsa008300.61192559
117Hepatitis C_Homo sapiens_hsa051600.59995215
118ECM-receptor interaction_Homo sapiens_hsa045120.59740863
119Fat digestion and absorption_Homo sapiens_hsa049750.59678594
120Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.59591765
121Legionellosis_Homo sapiens_hsa051340.58962358
122Fatty acid biosynthesis_Homo sapiens_hsa000610.58359170
123Drug metabolism - other enzymes_Homo sapiens_hsa009830.58179354
124Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.57815661
125T cell receptor signaling pathway_Homo sapiens_hsa046600.57522350
126Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.57005196
127Vibrio cholerae infection_Homo sapiens_hsa051100.56232830
128Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.56070497
129Osteoclast differentiation_Homo sapiens_hsa043800.55782478
130Morphine addiction_Homo sapiens_hsa050320.55572996
131Bile secretion_Homo sapiens_hsa049760.55151433
132Starch and sucrose metabolism_Homo sapiens_hsa005000.52617573
133Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.52099308
134Jak-STAT signaling pathway_Homo sapiens_hsa046300.51397855
135Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.51026852
136Glutamatergic synapse_Homo sapiens_hsa047240.50866765
137Sulfur metabolism_Homo sapiens_hsa009200.50531151
138Chemical carcinogenesis_Homo sapiens_hsa052040.50250494
139Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.50201547
140African trypanosomiasis_Homo sapiens_hsa051430.49591238
141Purine metabolism_Homo sapiens_hsa002300.47136831
142Renin secretion_Homo sapiens_hsa049240.46503516
143Malaria_Homo sapiens_hsa051440.45675628
144Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.45277002
145Fatty acid metabolism_Homo sapiens_hsa012120.45090911
146Phototransduction_Homo sapiens_hsa047440.44000797
147Notch signaling pathway_Homo sapiens_hsa043300.42952897
148Melanogenesis_Homo sapiens_hsa049160.42475272
149Wnt signaling pathway_Homo sapiens_hsa043100.42062747
150Hematopoietic cell lineage_Homo sapiens_hsa046400.41950250
151Cell cycle_Homo sapiens_hsa041100.41711571
152Complement and coagulation cascades_Homo sapiens_hsa046100.41337216
153Tuberculosis_Homo sapiens_hsa051520.40280628
154Tight junction_Homo sapiens_hsa045300.40076596
155One carbon pool by folate_Homo sapiens_hsa006700.39026556
156p53 signaling pathway_Homo sapiens_hsa041150.38053467
157Epstein-Barr virus infection_Homo sapiens_hsa051690.36852254
158Ras signaling pathway_Homo sapiens_hsa040140.36162728
159Pancreatic cancer_Homo sapiens_hsa052120.35724243
160Calcium signaling pathway_Homo sapiens_hsa040200.35028265
161Chemokine signaling pathway_Homo sapiens_hsa040620.34759764
162Transcriptional misregulation in cancer_Homo sapiens_hsa052020.34523694
163Nucleotide excision repair_Homo sapiens_hsa034200.33430449
164Small cell lung cancer_Homo sapiens_hsa052220.33259325
165Asthma_Homo sapiens_hsa053100.32977815
166Melanoma_Homo sapiens_hsa052180.32771804

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