DMRTA2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuronal stem cell maintenance (GO:0097150)8.14505453
2negative regulation of epidermal cell differentiation (GO:0045605)8.03458033
3limb bud formation (GO:0060174)8.02350161
4lateral sprouting from an epithelium (GO:0060601)7.08252749
5kidney morphogenesis (GO:0060993)7.02144151
6epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.48565082
7glial cell proliferation (GO:0014009)6.39447425
8negative regulation of epidermis development (GO:0045683)6.33395062
9negative regulation of interleukin-10 production (GO:0032693)6.27560365
10left/right axis specification (GO:0070986)6.02719269
11* dopaminergic neuron differentiation (GO:0071542)5.94496693
12epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)5.66616547
13nephron tubule development (GO:0072080)5.64529224
14establishment of tissue polarity (GO:0007164)5.62371429
15establishment of planar polarity (GO:0001736)5.62371429
16axon extension involved in axon guidance (GO:0048846)5.45829195
17neuron projection extension involved in neuron projection guidance (GO:1902284)5.45829195
18cell proliferation in forebrain (GO:0021846)5.45743182
19behavioral response to nicotine (GO:0035095)5.37512291
20neural tube formation (GO:0001841)5.36561176
21renal tubule development (GO:0061326)5.08816273
22cardiac ventricle formation (GO:0003211)5.08320463
23sympathetic nervous system development (GO:0048485)4.92007984
24primitive streak formation (GO:0090009)4.82216674
25axonemal dynein complex assembly (GO:0070286)4.67550992
26dendritic spine morphogenesis (GO:0060997)4.65006344
27nephron epithelium development (GO:0072009)4.63743495
28ganglion development (GO:0061548)4.63493944
29paraxial mesoderm development (GO:0048339)4.60211778
30positive regulation of Notch signaling pathway (GO:0045747)4.58755138
31cardiac chamber formation (GO:0003207)4.58002579
32face development (GO:0060324)4.56852899
33substrate-independent telencephalic tangential interneuron migration (GO:0021843)4.55998791
34substrate-independent telencephalic tangential migration (GO:0021826)4.55998791
35cell surface receptor signaling pathway involved in heart development (GO:0061311)4.54543530
36Notch signaling involved in heart development (GO:0061314)4.44077933
37segment specification (GO:0007379)4.41793131
38planar cell polarity pathway involved in neural tube closure (GO:0090179)4.41029187
39ventricular septum morphogenesis (GO:0060412)4.33493996
40heart valve formation (GO:0003188)4.27867594
41atrial septum morphogenesis (GO:0060413)4.21644303
42positive regulation of gastrulation (GO:2000543)4.16760305
43postsynaptic membrane organization (GO:0001941)4.09170585
44epithelial cilium movement (GO:0003351)4.08621784
45cardiac right ventricle morphogenesis (GO:0003215)4.08283182
46midbrain development (GO:0030901)4.07113484
47layer formation in cerebral cortex (GO:0021819)4.03874719
48central nervous system neuron development (GO:0021954)3.99688950
49lymphoid progenitor cell differentiation (GO:0002320)3.98464710
50endocardial cushion morphogenesis (GO:0003203)3.93560617
51spinal cord development (GO:0021510)3.91235460
52presynaptic membrane assembly (GO:0097105)3.88505005
53Notch receptor processing (GO:0007220)3.87354263
54regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.85294382
55negative regulation of axon guidance (GO:1902668)3.83727390
56somite development (GO:0061053)3.80939251
57DNA damage response, detection of DNA damage (GO:0042769)3.71549271
58presynaptic membrane organization (GO:0097090)3.69624569
59dentate gyrus development (GO:0021542)3.69158453
60heart valve morphogenesis (GO:0003179)3.66626983
61lung epithelium development (GO:0060428)3.66229877
62thalamus development (GO:0021794)3.65458711
63intraciliary transport (GO:0042073)3.63406115
64sequestering of actin monomers (GO:0042989)3.58502368
65cochlea morphogenesis (GO:0090103)3.55338802
66regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)3.54919645
67positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)3.54919645
68neuron recognition (GO:0008038)3.53972649
69cranial nerve morphogenesis (GO:0021602)3.53835847
70negative regulation of transcription regulatory region DNA binding (GO:2000678)3.52086297
71urogenital system development (GO:0001655)3.48810729
72pyrimidine nucleobase catabolic process (GO:0006208)3.48083109
73transmission of nerve impulse (GO:0019226)3.47791073
74notochord development (GO:0030903)3.46739332
75negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)3.45583493
76cilium movement (GO:0003341)3.42720510
77forebrain neuron differentiation (GO:0021879)3.42346629
78retinal ganglion cell axon guidance (GO:0031290)3.40594531
79ventricular trabecula myocardium morphogenesis (GO:0003222)3.39621278
80glomerulus development (GO:0032835)3.39102615
81nucleobase catabolic process (GO:0046113)3.38798818
82short-term memory (GO:0007614)3.36824714
83regulation of cilium movement (GO:0003352)3.34288770
84regulation of alternative mRNA splicing, via spliceosome (GO:0000381)3.33406690
85regulation of microtubule-based movement (GO:0060632)3.33023104
86cellular protein complex disassembly (GO:0043624)3.32847206
87regulation of cell-cell adhesion mediated by cadherin (GO:2000047)3.31262400
88cotranslational protein targeting to membrane (GO:0006613)3.30806827
89SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.30670167
90ribosomal small subunit biogenesis (GO:0042274)3.30457964
91axon extension (GO:0048675)3.28909327
92auditory behavior (GO:0031223)3.26698486
93heart trabecula morphogenesis (GO:0061384)3.25701972
94DNA topological change (GO:0006265)3.25124373
95embryonic foregut morphogenesis (GO:0048617)3.24570469
96negative chemotaxis (GO:0050919)3.23125657
97negative regulation of appetite (GO:0032099)3.22759568
98negative regulation of response to food (GO:0032096)3.22759568
99alanine transport (GO:0032328)3.22334462
100regulation of development, heterochronic (GO:0040034)3.22192627
101translational elongation (GO:0006414)3.22117814
102protein localization to synapse (GO:0035418)3.21838606
103regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.21673572
104protein targeting to ER (GO:0045047)3.21485311
105nonmotile primary cilium assembly (GO:0035058)3.19320498
106microtubule depolymerization (GO:0007019)3.18168505
107Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.18127245
108embryonic epithelial tube formation (GO:0001838)3.13017542
109female genitalia development (GO:0030540)3.12057974
110mesenchyme morphogenesis (GO:0072132)3.10841694
111chemosensory behavior (GO:0007635)3.08751410
112viral transcription (GO:0019083)3.07499137
113ribosomal small subunit assembly (GO:0000028)3.07035597
114establishment of protein localization to endoplasmic reticulum (GO:0072599)3.05162991
115epithelial cell differentiation involved in prostate gland development (GO:0060742)3.04885273
116cell migration in hindbrain (GO:0021535)3.04317336
117embryonic pattern specification (GO:0009880)3.03215931
118protein complex disassembly (GO:0043241)3.03006366
119spinal cord association neuron differentiation (GO:0021527)3.00611050
120negative regulation of axon extension involved in axon guidance (GO:0048843)2.99979208
121epithelial tube formation (GO:0072175)2.99691628
122positive regulation of oligodendrocyte differentiation (GO:0048714)2.97823561
123renal system development (GO:0072001)2.97316499
124viral life cycle (GO:0019058)2.96975612
125nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.96622847
126G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.96307903
127neuron cell-cell adhesion (GO:0007158)2.95390554
128hindbrain development (GO:0030902)2.95267120
129establishment of protein localization to mitochondrial membrane (GO:0090151)2.93353726
130olfactory bulb development (GO:0021772)2.93155146
131cerebral cortex radially oriented cell migration (GO:0021799)2.93108104
132eyelid development in camera-type eye (GO:0061029)2.92699151
133axonal fasciculation (GO:0007413)2.92696958
134protein localization to endoplasmic reticulum (GO:0070972)2.92291326
135regulation of collateral sprouting (GO:0048670)2.92150733
136positive regulation of neurological system process (GO:0031646)2.91102170
137macromolecular complex disassembly (GO:0032984)2.90808952
138negative regulation of axon extension (GO:0030517)2.90168058
139dendrite development (GO:0016358)2.89949636
140regulation of establishment of planar polarity (GO:0090175)2.89545274
141negative regulation of axonogenesis (GO:0050771)2.88837641
142lung-associated mesenchyme development (GO:0060484)2.88673587
143ATP synthesis coupled proton transport (GO:0015986)2.87804911
144energy coupled proton transport, down electrochemical gradient (GO:0015985)2.87804911
145neuron fate determination (GO:0048664)2.87393214
146regulation of somitogenesis (GO:0014807)2.85971122
147spinal cord motor neuron differentiation (GO:0021522)2.85835363
148somite rostral/caudal axis specification (GO:0032525)2.85562054
149mitochondrial respiratory chain complex I assembly (GO:0032981)2.85252739
150NADH dehydrogenase complex assembly (GO:0010257)2.85252739
151mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.85252739
152* positive regulation of neuroblast proliferation (GO:0002052)2.84933343
153translational termination (GO:0006415)2.84262357
154regulation of mesenchymal cell apoptotic process (GO:2001053)2.84156420
155cardiac ventricle morphogenesis (GO:0003208)2.83825871
156embryonic hindlimb morphogenesis (GO:0035116)2.80827937
157mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.80490797
158mechanosensory behavior (GO:0007638)2.79783771
159negative regulation of oligodendrocyte differentiation (GO:0048715)2.79562116
160regulation of axon guidance (GO:1902667)2.79166665
161regulation of cardioblast proliferation (GO:0003264)2.79139047
162regulation of secondary heart field cardioblast proliferation (GO:0003266)2.79139047
163base-excision repair, AP site formation (GO:0006285)2.77832503
164central nervous system myelination (GO:0022010)2.77732286
165axon ensheathment in central nervous system (GO:0032291)2.77732286
166regulation of timing of cell differentiation (GO:0048505)2.76305501
167neurotransmitter-gated ion channel clustering (GO:0072578)2.75969253
168determination of left/right symmetry (GO:0007368)2.73013427
169limb development (GO:0060173)2.71258347
170appendage development (GO:0048736)2.71258347
171synapse assembly (GO:0007416)2.67220830
172cell differentiation in spinal cord (GO:0021515)2.66742827
173smoothened signaling pathway (GO:0007224)2.65040387
174otic vesicle formation (GO:0030916)2.64221158
175regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.63830118
176dorsal/ventral neural tube patterning (GO:0021904)2.62725495

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human4.65373833
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.01570941
3* EZH2_27304074_Chip-Seq_ESCs_Mouse3.69162293
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.42210260
5* EED_16625203_ChIP-ChIP_MESCs_Mouse3.30144696
6RBPJ_22232070_ChIP-Seq_NCS_Mouse3.18431578
7* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.11613825
8TP63_19390658_ChIP-ChIP_HaCaT_Human3.00591459
9* RNF2_18974828_ChIP-Seq_MESCs_Mouse3.00006028
10* EZH2_18974828_ChIP-Seq_MESCs_Mouse3.00006028
11* PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.99547527
12* CBX2_27304074_Chip-Seq_ESCs_Mouse2.89129896
13* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.83137357
14STAT6_21828071_ChIP-Seq_BEAS2B_Human2.80841203
15EZH2_22144423_ChIP-Seq_EOC_Human2.79636065
16* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.74998030
17POU5F1_16153702_ChIP-ChIP_HESCs_Human2.66885076
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.61040306
19* RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.59555984
20EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.58700794
21* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.56232863
22* RNF2_27304074_Chip-Seq_ESCs_Mouse2.53065261
23FOXM1_23109430_ChIP-Seq_U2OS_Human2.50694365
24* BMI1_23680149_ChIP-Seq_NPCS_Mouse2.39725036
25* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.37100126
26* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.34258730
27* EZH2_27294783_Chip-Seq_ESCs_Mouse2.31383318
28NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.27122611
29* TP53_20018659_ChIP-ChIP_R1E_Mouse2.09157161
30* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.08629775
31ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.03641222
32* RING1B_27294783_Chip-Seq_NPCs_Mouse2.03480076
33WT1_19549856_ChIP-ChIP_CCG9911_Human1.95301943
34* RING1B_27294783_Chip-Seq_ESCs_Mouse1.88151993
35* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.80073284
36VDR_22108803_ChIP-Seq_LS180_Human1.79407301
37ERG_21242973_ChIP-ChIP_JURKAT_Human1.79179235
38ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.76493048
39* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.74121872
40TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.70071456
41TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.67257708
42FUS_26573619_Chip-Seq_HEK293_Human1.66785645
43EWS_26573619_Chip-Seq_HEK293_Human1.63466840
44RNF2_27304074_Chip-Seq_NSC_Mouse1.62406979
45GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.57780232
46RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.57668955
47* REST_18959480_ChIP-ChIP_MESCs_Mouse1.56137699
48TAF15_26573619_Chip-Seq_HEK293_Human1.55896931
49MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.48225018
50SOX2_16153702_ChIP-ChIP_HESCs_Human1.47648464
51* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.47184018
52CTBP1_25329375_ChIP-Seq_LNCAP_Human1.46438831
53CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.45272297
54SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.42824662
55ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.42609505
56CTBP2_25329375_ChIP-Seq_LNCAP_Human1.42138291
57ZFP281_18757296_ChIP-ChIP_E14_Mouse1.41702392
58SALL1_21062744_ChIP-ChIP_HESCs_Human1.40873984
59POU3F2_20337985_ChIP-ChIP_501MEL_Human1.40383349
60WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.34543323
61* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.27140806
62NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.26515193
63TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25819160
64POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.25819160
65CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.25662500
66* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.23052557
67KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.20964719
68HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.20213773
69AR_25329375_ChIP-Seq_VCAP_Human1.18950900
70* SOX2_18555785_ChIP-Seq_MESCs_Mouse1.18556119
71GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.17649897
72TOP2B_26459242_ChIP-Seq_MCF-7_Human1.17546622
73P300_19829295_ChIP-Seq_ESCs_Human1.16779822
74MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.16619780
75TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14577510
76* SMAD4_21799915_ChIP-Seq_A2780_Human1.14460449
77TP53_18474530_ChIP-ChIP_U2OS_Human1.13124366
78* REST_21632747_ChIP-Seq_MESCs_Mouse1.12268839
79POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.11787407
80MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.10280021
81SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.09183819
82IGF1R_20145208_ChIP-Seq_DFB_Human1.08640106
83ER_23166858_ChIP-Seq_MCF-7_Human1.06932294
84AR_21572438_ChIP-Seq_LNCaP_Human1.06434026
85SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.06037433
86UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.05975264
87CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.05558480
88ISL1_27105846_Chip-Seq_CPCs_Mouse1.05331515
89CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.05121559
90P53_22127205_ChIP-Seq_FIBROBLAST_Human1.04437175
91ZFP57_27257070_Chip-Seq_ESCs_Mouse1.04100531
92SMAD3_21741376_ChIP-Seq_EPCs_Human1.02236749
93DROSHA_22980978_ChIP-Seq_HELA_Human1.01910210
94* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.01609787
95STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.00172167
96AHR_22903824_ChIP-Seq_MCF-7_Human0.99827624
97TCF3_18692474_ChIP-Seq_MEFs_Mouse0.99214378
98ETV2_25802403_ChIP-Seq_MESCs_Mouse0.99077265
99SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98954894
100ZFP281_27345836_Chip-Seq_ESCs_Mouse0.98557567
101* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.96662458
102SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.95457223
103E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.94946443
104* TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.94285243
105HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.94165881
106GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.94129470
107ESR1_21235772_ChIP-Seq_MCF-7_Human0.93987069
108ARNT_22903824_ChIP-Seq_MCF-7_Human0.91762757
109GBX2_23144817_ChIP-Seq_PC3_Human0.91374212
110BCAT_22108803_ChIP-Seq_LS180_Human0.91012653
111WDR5_24793694_ChIP-Seq_LNCAP_Human0.89613406
112KLF5_20875108_ChIP-Seq_MESCs_Mouse0.89258457
113KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.89072132
114KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.89072132
115KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.89072132
116KDM2B_26808549_Chip-Seq_K562_Human0.88600398
117PIAS1_25552417_ChIP-Seq_VCAP_Human0.88476388
118TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.88259620
119IKZF1_21737484_ChIP-ChIP_HCT116_Human0.87934439
120ZNF274_21170338_ChIP-Seq_K562_Hela0.87837778
121EST1_17652178_ChIP-ChIP_JURKAT_Human0.87700845
122CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87688551
123CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.87307573
124EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.87049222
125GF1_26923725_Chip-Seq_HPCs_Mouse0.86371391
126* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.86186765
127GATA1_26923725_Chip-Seq_HPCs_Mouse0.86180947
128NR3C1_21868756_ChIP-Seq_MCF10A_Human0.85727465
129* STAT3_18555785_ChIP-Seq_MESCs_Mouse0.85719329
130FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.85568595
131* SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.85195137
132RUNX2_22187159_ChIP-Seq_PCA_Human0.84985474
133TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84786129
134ELK4_26923725_Chip-Seq_MESODERM_Mouse0.84658564
135* CTCF_27219007_Chip-Seq_Bcells_Human0.84533087
136FOXM1_26456572_ChIP-Seq_MCF-7_Human0.83880734
137TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.83214613
138ZNF217_24962896_ChIP-Seq_MCF-7_Human0.83105548
139EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.82697164
140SOX3_22085726_ChIP-Seq_NPCs_Mouse0.81431134

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000566_synostosis6.21907557
2MP0010030_abnormal_orbit_morphology3.77658234
3MP0002751_abnormal_autonomic_nervous3.66588716
4MP0008961_abnormal_basal_metabolism3.60436747
5MP0004133_heterotaxia3.53954572
6MP0003938_abnormal_ear_development3.45966515
7MP0008789_abnormal_olfactory_epithelium3.10414703
8MP0005499_abnormal_olfactory_system2.99338407
9MP0005394_taste/olfaction_phenotype2.99338407
10MP0006292_abnormal_olfactory_placode2.87993024
11MP0000049_abnormal_middle_ear2.70488905
12MP0002282_abnormal_trachea_morphology2.49841638
13MP0002653_abnormal_ependyma_morphology2.41768028
14MP0002102_abnormal_ear_morphology2.39756308
15MP0002822_catalepsy2.31706888
16MP0000778_abnormal_nervous_system2.17250079
17MP0009053_abnormal_anal_canal2.09305256
18MP0002938_white_spotting2.07920272
19MP0000537_abnormal_urethra_morphology2.06732632
20MP0003937_abnormal_limbs/digits/tail_de2.06108642
21MP0002234_abnormal_pharynx_morphology2.02401259
22MP0003283_abnormal_digestive_organ1.97613344
23MP0009379_abnormal_foot_pigmentation1.95679724
24MP0004742_abnormal_vestibular_system1.93918276
25MP0000026_abnormal_inner_ear1.90822123
26MP0002233_abnormal_nose_morphology1.90694333
27MP0000467_abnormal_esophagus_morphology1.86394275
28MP0005423_abnormal_somatic_nervous1.79895943
29MP0003787_abnormal_imprinting1.78284220
30MP0003315_abnormal_perineum_morphology1.77023709
31MP0003385_abnormal_body_wall1.71513075
32MP0000631_abnormal_neuroendocrine_gland1.69166312
33MP0003890_abnormal_embryonic-extraembry1.66419598
34MP0001485_abnormal_pinna_reflex1.62160257
35MP0006276_abnormal_autonomic_nervous1.62144534
36MP0005248_abnormal_Harderian_gland1.59035803
37MP0003755_abnormal_palate_morphology1.58243061
38MP0002249_abnormal_larynx_morphology1.55819513
39MP0003115_abnormal_respiratory_system1.54321715
40MP0003119_abnormal_digestive_system1.51364556
41MP0001286_abnormal_eye_development1.47054794
42MP0004145_abnormal_muscle_electrophysio1.45832467
43MP0001346_abnormal_lacrimal_gland1.45194556
44MP0003861_abnormal_nervous_system1.44014936
45MP0003011_delayed_dark_adaptation1.42313044
46MP0003635_abnormal_synaptic_transmissio1.38913815
47MP0003137_abnormal_impulse_conducting1.38874601
48MP0002272_abnormal_nervous_system1.38402559
49MP0003942_abnormal_urinary_system1.38396572
50MP0005551_abnormal_eye_electrophysiolog1.36903660
51MP0002572_abnormal_emotion/affect_behav1.35378031
52MP0002734_abnormal_mechanical_nocicepti1.35361845
53MP0000955_abnormal_spinal_cord1.31350151
54MP0002932_abnormal_joint_morphology1.30762527
55MP0002697_abnormal_eye_size1.29611328
56MP0002064_seizures1.28556550
57MP0002063_abnormal_learning/memory/cond1.26422935
58MP0000733_abnormal_muscle_development1.25238876
59MP0002177_abnormal_outer_ear1.24408480
60MP0000579_abnormal_nail_morphology1.23315750
61MP0001486_abnormal_startle_reflex1.22012582
62MP0002184_abnormal_innervation1.20216512
63MP0002067_abnormal_sensory_capabilities1.20179299
64MP0004859_abnormal_synaptic_plasticity1.18598377
65MP0009250_abnormal_appendicular_skeleto1.18422902
66MP0004885_abnormal_endolymph1.16879784
67MP0008995_early_reproductive_senescence1.15857322
68MP0002116_abnormal_craniofacial_bone1.15847197
69MP0005195_abnormal_posterior_eye1.15588930
70MP0002108_abnormal_muscle_morphology1.13061765
71MP0008877_abnormal_DNA_methylation1.12609372
72MP0003935_abnormal_craniofacial_develop1.12251650
73MP0000383_abnormal_hair_follicle1.12028462
74MP0003959_abnormal_lean_body1.11543257
75MP0004142_abnormal_muscle_tone1.11403445
76MP0002735_abnormal_chemical_nociception1.09164411
77MP0003121_genomic_imprinting1.07255364
78MP0002752_abnormal_somatic_nervous1.04370225
79MP0001970_abnormal_pain_threshold1.04027572
80MP0003880_abnormal_central_pattern1.03779861
81MP0001293_anophthalmia1.03555327
82MP0002092_abnormal_eye_morphology1.03533219
83MP0009046_muscle_twitch1.03180506
84MP0002163_abnormal_gland_morphology1.02412403
85MP0003136_yellow_coat_color1.01409974
86MP0005377_hearing/vestibular/ear_phenot1.00504783
87MP0003878_abnormal_ear_physiology1.00504783
88MP0002277_abnormal_respiratory_mucosa0.99067286
89MP0000762_abnormal_tongue_morphology0.98914709
90MP0001348_abnormal_lacrimal_gland0.98452409
91MP0000428_abnormal_craniofacial_morphol0.97107961
92MP0001299_abnormal_eye_distance/0.96606471
93MP0001905_abnormal_dopamine_level0.95460247
94MP0003567_abnormal_fetal_cardiomyocyte0.95315320
95MP0002152_abnormal_brain_morphology0.94717847
96MP0000647_abnormal_sebaceous_gland0.91328417
97MP0002733_abnormal_thermal_nociception0.91040613
98MP0006072_abnormal_retinal_apoptosis0.89695325
99MP0001188_hyperpigmentation0.87747235
100MP0001440_abnormal_grooming_behavior0.87726082
101MP0002081_perinatal_lethality0.87226693
102MP0000613_abnormal_salivary_gland0.86571187
103MP0009780_abnormal_chondrocyte_physiolo0.86318147
104MP0002909_abnormal_adrenal_gland0.85476492
105MP0002882_abnormal_neuron_morphology0.85443771
106MP0004924_abnormal_behavior0.85381105
107MP0005386_behavior/neurological_phenoty0.85381105
108MP0001984_abnormal_olfaction0.84115805
109MP0003646_muscle_fatigue0.83780407
110MP0002557_abnormal_social/conspecific_i0.83615170
111MP0005391_vision/eye_phenotype0.83562815
112MP0003123_paternal_imprinting0.83152147
113MP0002638_abnormal_pupillary_reflex0.82192404
114MP0005187_abnormal_penis_morphology0.82160892
115MP0002111_abnormal_tail_morphology0.81453612
116MP0005646_abnormal_pituitary_gland0.77042356
117MP0001529_abnormal_vocalization0.75819521
118MP0004134_abnormal_chest_morphology0.75359900
119MP0005379_endocrine/exocrine_gland_phen0.73006501
120MP0000534_abnormal_ureter_morphology0.71847059
121MP0002114_abnormal_axial_skeleton0.71124986
122MP0005408_hypopigmentation0.69751434
123MP0009745_abnormal_behavioral_response0.69741136
124MP0003122_maternal_imprinting0.69505917
125MP0005197_abnormal_uvea_morphology0.67916072
126MP0001963_abnormal_hearing_physiology0.66703488
127MP0003866_abnormal_defecation0.66488045
128MP0004085_abnormal_heartbeat0.66456060
129MP0004811_abnormal_neuron_physiology0.66053288
130MP0005508_abnormal_skeleton_morphology0.65613487
131MP0005253_abnormal_eye_physiology0.63522601
132MP0004270_analgesia0.63012470
133MP0001944_abnormal_pancreas_morphology0.62957959
134MP0002098_abnormal_vibrissa_morphology0.61712771
135MP0004858_abnormal_nervous_system0.60586413
136MP0000432_abnormal_head_morphology0.60266769
137MP0002085_abnormal_embryonic_tissue0.60179162

Predicted human phenotypes

RankGene SetZ-score
1Oligodactyly (hands) (HP:0001180)6.80061040
2Oligodactyly (HP:0012165)5.37132086
3Chin dimple (HP:0010751)5.26194023
4Down-sloping shoulders (HP:0200021)5.25930838
5Intestinal atresia (HP:0011100)5.18140495
6Double outlet right ventricle (HP:0001719)4.76342826
7Congenital malformation of the right heart (HP:0011723)4.76342826
8Anophthalmia (HP:0000528)4.63252711
9Mixed hearing impairment (HP:0000410)4.59840564
10Abnormality of the parathyroid morphology (HP:0011766)4.54098888
11Abnormal respiratory epithelium morphology (HP:0012253)4.39598762
12Abnormal respiratory motile cilium morphology (HP:0005938)4.39598762
13Esophageal atresia (HP:0002032)4.12819767
14Labial hypoplasia (HP:0000066)4.06679650
15Dynein arm defect of respiratory motile cilia (HP:0012255)3.99692405
16Absent/shortened dynein arms (HP:0200106)3.99692405
17Aqueductal stenosis (HP:0002410)3.87329781
18Hypoplastic female external genitalia (HP:0012815)3.84504404
19Abnormal ciliary motility (HP:0012262)3.80048062
20Molar tooth sign on MRI (HP:0002419)3.66481816
21Abnormality of midbrain morphology (HP:0002418)3.66481816
22Abnormal respiratory motile cilium physiology (HP:0012261)3.61923784
23Myokymia (HP:0002411)3.60141629
24Septo-optic dysplasia (HP:0100842)3.32347985
25Pancreatic fibrosis (HP:0100732)3.31016927
26Deep palmar crease (HP:0006191)3.30159461
27True hermaphroditism (HP:0010459)3.27906689
28Growth hormone deficiency (HP:0000824)3.19508080
29Type II lissencephaly (HP:0007260)3.14447061
30Anosmia (HP:0000458)3.14244525
31Pancreatic cysts (HP:0001737)3.13209776
32Cupped ear (HP:0000378)3.09418296
33Gait imbalance (HP:0002141)3.08240553
34Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.05607607
35Concave nail (HP:0001598)3.03642231
36Abnormality of the antihelix (HP:0009738)3.03229755
37Nephronophthisis (HP:0000090)2.99772917
38Supernumerary spleens (HP:0009799)2.95773564
39Abnormality of the labia (HP:0000058)2.94776344
40Stenosis of the external auditory canal (HP:0000402)2.93188288
41Horseshoe kidney (HP:0000085)2.92306122
42Thyroiditis (HP:0100646)2.90932572
43Absent radius (HP:0003974)2.89202880
44Maternal diabetes (HP:0009800)2.86906387
45Bifid scrotum (HP:0000048)2.86842513
46Medial flaring of the eyebrow (HP:0010747)2.85947101
47Hepatoblastoma (HP:0002884)2.82490108
48Absent forearm bone (HP:0003953)2.81988282
49Aplasia involving forearm bones (HP:0009822)2.81988282
50Diastasis recti (HP:0001540)2.81160714
51Severe combined immunodeficiency (HP:0004430)2.80103917
52Hemivertebrae (HP:0002937)2.75071623
53Congenital primary aphakia (HP:0007707)2.71934247
54Aplasia/Hypoplasia of the sternum (HP:0006714)2.70549812
55Cerebellar dysplasia (HP:0007033)2.70149848
56Rhinitis (HP:0012384)2.63319379
57Ridged nail (HP:0001807)2.61924416
58Morphological abnormality of the middle ear (HP:0008609)2.61421868
59Overfolded helix (HP:0000396)2.59762606
60Anal stenosis (HP:0002025)2.59454952
61Rib fusion (HP:0000902)2.55513366
62Facial hemangioma (HP:0000329)2.55367392
63Gastrointestinal atresia (HP:0002589)2.53241741
64Birth length less than 3rd percentile (HP:0003561)2.52970009
65Myelomeningocele (HP:0002475)2.48949419
66Abnormality of the renal medulla (HP:0100957)2.48513257
67Fibular aplasia (HP:0002990)2.46674920
68Cystic liver disease (HP:0006706)2.44770602
69Vaginal atresia (HP:0000148)2.44172643
70Anencephaly (HP:0002323)2.42032700
71Anterior segment dysgenesis (HP:0007700)2.39809041
72Bilateral microphthalmos (HP:0007633)2.35295712
73Genital tract atresia (HP:0001827)2.35007561
74Coronal craniosynostosis (HP:0004440)2.34393113
75Cleft eyelid (HP:0000625)2.34151472
76Congenital, generalized hypertrichosis (HP:0004540)2.33884065
77Aplasia involving bones of the extremities (HP:0009825)2.32520234
78Aplasia involving bones of the upper limbs (HP:0009823)2.32520234
79Aplasia of the phalanges of the hand (HP:0009802)2.32520234
80Abnormally folded helix (HP:0008544)2.32338384
81Triphalangeal thumb (HP:0001199)2.31424225
82Congenital stationary night blindness (HP:0007642)2.30817739
83Aplasia/Hypoplasia of the earlobes (HP:0009906)2.30751336
84Abnormality of secondary sexual hair (HP:0009888)2.28765496
85Abnormality of the axillary hair (HP:0100134)2.28765496
86Nephrogenic diabetes insipidus (HP:0009806)2.28374533
87Lissencephaly (HP:0001339)2.27786948
88Laryngomalacia (HP:0001601)2.27672326
89Germ cell neoplasia (HP:0100728)2.26353110
90Combined immunodeficiency (HP:0005387)2.25653703
91Abnormal number of incisors (HP:0011064)2.23431004
92Aplasia/Hypoplasia of the ulna (HP:0006495)2.20986859
93Limb dystonia (HP:0002451)2.19945352
94Hypoplasia of the ulna (HP:0003022)2.19409230
95Sex reversal (HP:0012245)2.18116908
96Abnormal sex determination (HP:0012244)2.18116908
97Renal hypoplasia (HP:0000089)2.15850248
98Hyperventilation (HP:0002883)2.11993903
99Poor coordination (HP:0002370)2.10792763
100Tubulointerstitial fibrosis (HP:0005576)2.10133321
101Abnormality of cells of the erythroid lineage (HP:0012130)2.09584997
102Postaxial hand polydactyly (HP:0001162)2.09338219
103Bifid tongue (HP:0010297)2.06519035
10411 pairs of ribs (HP:0000878)2.05204613
105Abnormality of the proximal phalanges of the hand (HP:0009834)2.05103299
106Preaxial foot polydactyly (HP:0001841)2.04826531
107Reticulocytopenia (HP:0001896)2.01513095
108Pterygium (HP:0001059)2.00799284
109Aplasia/Hypoplasia of the patella (HP:0006498)1.99327163
110Omphalocele (HP:0001539)1.98816238
111Long clavicles (HP:0000890)1.98671660
112Postaxial foot polydactyly (HP:0001830)1.98285935
113Increased hepatocellular lipid droplets (HP:0006565)1.97953887
114Patellar aplasia (HP:0006443)1.97744360
115Short middle phalanx of the 5th finger (HP:0004220)1.97534438
116Abnormal number of erythroid precursors (HP:0012131)1.97334213
117Progressive cerebellar ataxia (HP:0002073)1.96832603
118Sclerocornea (HP:0000647)1.95636875
119Sleep apnea (HP:0010535)1.95125510
120Focal motor seizures (HP:0011153)1.94569257
121Abnormality of the diencephalon (HP:0010662)1.93757252
122Abnormality of abdominal situs (HP:0011620)1.92355781
123Abdominal situs inversus (HP:0003363)1.92355781
124Acute necrotizing encephalopathy (HP:0006965)1.92256748
125Bony spicule pigmentary retinopathy (HP:0007737)1.91779332
126Chronic hepatic failure (HP:0100626)1.91682874
127Macrocytic anemia (HP:0001972)1.90869323
128Preaxial hand polydactyly (HP:0001177)1.90453628
129Partial duplication of the phalanx of hand (HP:0009999)1.90235267
130Retinal dysplasia (HP:0007973)1.89869991
131Holoprosencephaly (HP:0001360)1.89783663
132Dandy-Walker malformation (HP:0001305)1.88029728
133Long foot (HP:0001833)1.87733705
134Abnormality of the 4th metacarpal (HP:0010012)1.86341852
135Absent septum pellucidum (HP:0001331)1.85369383
136Abnormality of the phalanges of the 2nd finger (HP:0009541)1.85153892
137Chronic sinusitis (HP:0011109)1.84795470
138Amblyopia (HP:0000646)1.84603803
1393-Methylglutaconic aciduria (HP:0003535)1.82893786
140Pachygyria (HP:0001302)1.82611372
141Tubulointerstitial abnormality (HP:0001969)1.80346366
142Optic nerve hypoplasia (HP:0000609)1.80116509
143Alacrima (HP:0000522)1.80032841
144Abnormality of the labia minora (HP:0012880)1.76891390
145Mitochondrial inheritance (HP:0001427)1.76696389
146Specific learning disability (HP:0001328)1.75574288
147Renal agenesis (HP:0000104)1.75351487
148Broad distal phalanx of finger (HP:0009836)1.75123286
149Synostosis of carpal bones (HP:0005048)1.74935255
150Polyphagia (HP:0002591)1.74103084
151Microtia (HP:0008551)1.73919405
152Pendular nystagmus (HP:0012043)1.73041018
153Large eyes (HP:0001090)1.72826094
154Lipid accumulation in hepatocytes (HP:0006561)1.72745501
155Epileptic encephalopathy (HP:0200134)1.72710519
156Congenital hepatic fibrosis (HP:0002612)1.72608730
157Narrow forehead (HP:0000341)1.71882923
158Partial duplication of thumb phalanx (HP:0009944)1.71634169
159Tubular atrophy (HP:0000092)1.71110121
160Breast hypoplasia (HP:0003187)1.70991674
161Nuclear cataract (HP:0100018)1.70597763
162Asymmetry of the thorax (HP:0001555)1.70075128
163Micropenis (HP:0000054)1.69671927
164Aplasia/Hypoplasia of the tongue (HP:0010295)1.69254868
165Impulsivity (HP:0100710)1.68768490
166Preauricular skin tag (HP:0000384)1.67930159
167Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.67699753
168Short 4th metacarpal (HP:0010044)1.67699753
169Short 1st metacarpal (HP:0010034)1.67366280
170Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.67366280
171Synostosis involving bones of the lower limbs (HP:0009138)1.67059904
172Synostosis involving bones of the feet (HP:0009140)1.67059904
173Mesomelia (HP:0003027)1.66937830
174Abnormal hemoglobin (HP:0011902)1.66878728
175Short thumb (HP:0009778)1.66465315
176Abnormality of the septum pellucidum (HP:0007375)1.65956041
177Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.65389972
178Carpal synostosis (HP:0009702)1.62904850

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHB27.30373785
2MELK3.71786171
3LATS13.21931123
4CAMKK22.94655754
5MKNK22.91993405
6KSR12.76668909
7BRSK12.72365323
8WNK32.59392047
9STK38L2.57475770
10MKNK12.37997766
11MAPK152.33567899
12MARK12.21407288
13CAMKK12.03301602
14PAK31.88081576
15UHMK11.85787816
16TAF11.84612474
17SRPK11.84606749
18EPHA41.81415440
19NUAK11.81193908
20GSK3A1.77221234
21CDC42BPA1.74021695
22ICK1.68510789
23LRRK21.64846328
24ZAK1.64804648
25CDK81.60665720
26ERBB21.57881188
27NTRK31.57536538
28DYRK21.56361575
29NEK21.55505743
30DYRK31.55092579
31ACVR1B1.52163416
32DAPK21.48193552
33CDK91.46665407
34FGFR21.43614270
35CCNB11.39486466
36SIK11.33290573
37MAP3K41.30239763
38ERBB31.17325568
39TYRO31.15539858
40VRK21.14386296
41AURKA1.12616966
42MAPK111.11286077
43NME11.07245516
44ROCK21.07205046
45PNCK1.06265312
46VRK11.04320448
47MAP2K70.99338801
48RPS6KA40.97428986
49CDK70.95715643
50ADRBK10.95095520
51TLK10.94499059
52PRKCG0.93592294
53LATS20.93426061
54PLK40.92878033
55SGK4940.91629663
56SGK2230.91629663
57TNIK0.91470028
58WNK40.91238782
59CASK0.90739667
60WEE10.90519294
61BCR0.90057509
62MAP2K40.89126869
63STK160.88717306
64SGK20.87289791
65STK380.86057013
66GRK10.84737322
67NTRK20.83804887
68DYRK1B0.82219496
69CAMK10.79704755
70EPHA20.79475847
71TRIB30.78511972
72PASK0.77946086
73MUSK0.77247323
74TGFBR10.75856953
75PLK10.74434442
76FGR0.73556868
77RPS6KA10.71088334
78PKN10.71045476
79SIK20.69552852
80CAMK1D0.69411505
81TTK0.69085954
82EIF2AK20.69038838
83MAPK130.68694549
84BMPR1B0.68104316
85YES10.65101029
86PINK10.64706407
87PLK30.62891457
88DYRK1A0.62527997
89MST40.61999958
90BUB10.60529615
91MAP3K100.58995081
92PRKCZ0.57938363
93PAK20.55394755
94INSRR0.55008406
95ILK0.54429353
96CDK150.53894981
97CDK180.53886002
98CAMK2A0.52262280
99CLK10.51906676
100CDK140.49584285
101CAMK1G0.49569880
102PKN20.49454951
103CDK11A0.49230618
104PRKD30.48889514
105CSNK1E0.48072635
106PRKAA10.47893481
107PHKG20.47736433
108PHKG10.47736433
109MARK30.46894196
110CDK120.46678185
111ROCK10.46530390
112MAPKAPK20.41902999
113NEK60.41727000
114CDK60.40523772
115AURKB0.40487161
116CHEK20.40294024
117CDK10.40103236
118PRKACA0.39654593
119CDC70.39598092
120PLK20.39263617
121CDK30.39074836
122PTK60.37931206
123FER0.36965560
124MINK10.36809579
125FRK0.35257716
126ADRBK20.35107125
127PAK60.33736058
128CHUK0.33547723
129PRKG10.33240302
130STK110.32545239
131CSNK1G20.31578360
132CDK20.31369990
133EPHA30.30927605
134CAMK40.30856681
135PRKCE0.30596262
136DMPK0.28609751
137MAP3K70.28467878
138SGK10.28055548
139BRSK20.27529627
140CDK50.27159332
141SGK30.25993501
142CHEK10.25764425
143CDK190.24610080
144ERBB40.24564410
145CSNK1G10.23717664
146INSR0.23323603

Predicted pathways (KEGG)

RankGene SetZ-score
1Notch signaling pathway_Homo sapiens_hsa043304.23620579
2Basal cell carcinoma_Homo sapiens_hsa052173.72028767
3Ribosome_Homo sapiens_hsa030103.46902609
4Axon guidance_Homo sapiens_hsa043603.32394652
5Hedgehog signaling pathway_Homo sapiens_hsa043402.90600165
6Pentose and glucuronate interconversions_Homo sapiens_hsa000402.71525911
7Protein export_Homo sapiens_hsa030602.61936796
8Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045502.29164036
9Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.28871749
10Hippo signaling pathway_Homo sapiens_hsa043902.26893017
11Steroid hormone biosynthesis_Homo sapiens_hsa001402.18369319
12Spliceosome_Homo sapiens_hsa030402.10482081
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.05241522
14Melanogenesis_Homo sapiens_hsa049161.98919044
15Wnt signaling pathway_Homo sapiens_hsa043101.98241355
16Nicotine addiction_Homo sapiens_hsa050331.87737640
17Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.78765539
18Linoleic acid metabolism_Homo sapiens_hsa005911.76361201
19Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.71253082
20Cell cycle_Homo sapiens_hsa041101.67078399
21Autoimmune thyroid disease_Homo sapiens_hsa053201.55911732
22MicroRNAs in cancer_Homo sapiens_hsa052061.51365833
23alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.47967321
24Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.47237994
25TGF-beta signaling pathway_Homo sapiens_hsa043501.46038127
26Chemical carcinogenesis_Homo sapiens_hsa052041.45788244
27Cocaine addiction_Homo sapiens_hsa050301.45602614
28Regulation of autophagy_Homo sapiens_hsa041401.42268480
29Phototransduction_Homo sapiens_hsa047441.40489985
30Butanoate metabolism_Homo sapiens_hsa006501.40101200
31Fanconi anemia pathway_Homo sapiens_hsa034601.37925253
32Oxidative phosphorylation_Homo sapiens_hsa001901.35557557
33Maturity onset diabetes of the young_Homo sapiens_hsa049501.35196719
34Retinol metabolism_Homo sapiens_hsa008301.33543933
35Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.29117852
36Systemic lupus erythematosus_Homo sapiens_hsa053221.28501090
37Collecting duct acid secretion_Homo sapiens_hsa049661.28356486
38Homologous recombination_Homo sapiens_hsa034401.27879830
39Cardiac muscle contraction_Homo sapiens_hsa042601.27302271
40Basal transcription factors_Homo sapiens_hsa030221.27151829
41Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.25551621
42Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.24223927
43RNA polymerase_Homo sapiens_hsa030201.13325221
44Tight junction_Homo sapiens_hsa045301.12123684
45Insulin secretion_Homo sapiens_hsa049111.06734055
46GABAergic synapse_Homo sapiens_hsa047270.99645977
47Steroid biosynthesis_Homo sapiens_hsa001000.98020538
48Glutamatergic synapse_Homo sapiens_hsa047240.97451145
49Gastric acid secretion_Homo sapiens_hsa049710.96906421
50Drug metabolism - other enzymes_Homo sapiens_hsa009830.96445878
51Taste transduction_Homo sapiens_hsa047420.93940224
52Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.89831712
53Sulfur metabolism_Homo sapiens_hsa009200.87411742
54Alzheimers disease_Homo sapiens_hsa050100.85636653
55Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.85231833
56Alcoholism_Homo sapiens_hsa050340.85069126
57Non-homologous end-joining_Homo sapiens_hsa034500.84818182
58Ether lipid metabolism_Homo sapiens_hsa005650.84687949
59Parkinsons disease_Homo sapiens_hsa050120.84277172
60Vibrio cholerae infection_Homo sapiens_hsa051100.82724710
61Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.82518447
62Pathways in cancer_Homo sapiens_hsa052000.81432546
63Proteoglycans in cancer_Homo sapiens_hsa052050.81388772
64Transcriptional misregulation in cancer_Homo sapiens_hsa052020.79843011
65Lysine degradation_Homo sapiens_hsa003100.79251002
66Small cell lung cancer_Homo sapiens_hsa052220.78639546
67Morphine addiction_Homo sapiens_hsa050320.77967721
68cAMP signaling pathway_Homo sapiens_hsa040240.77706865
69Oxytocin signaling pathway_Homo sapiens_hsa049210.76156904
70Dopaminergic synapse_Homo sapiens_hsa047280.74394463
71Circadian entrainment_Homo sapiens_hsa047130.73849481
72Fat digestion and absorption_Homo sapiens_hsa049750.73498489
73Ovarian steroidogenesis_Homo sapiens_hsa049130.73006096
74Fatty acid biosynthesis_Homo sapiens_hsa000610.72473764
75Huntingtons disease_Homo sapiens_hsa050160.70696819
76Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.69823165
77RNA degradation_Homo sapiens_hsa030180.68554873
78Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.66515104
79Serotonergic synapse_Homo sapiens_hsa047260.66176913
80Starch and sucrose metabolism_Homo sapiens_hsa005000.65350260
81Glycerolipid metabolism_Homo sapiens_hsa005610.65011430
82Nucleotide excision repair_Homo sapiens_hsa034200.63998673
83Mismatch repair_Homo sapiens_hsa034300.63096287
84Primary bile acid biosynthesis_Homo sapiens_hsa001200.62643081
85Tryptophan metabolism_Homo sapiens_hsa003800.62371844
86Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.61646347
87Dorso-ventral axis formation_Homo sapiens_hsa043200.61279348
88Amphetamine addiction_Homo sapiens_hsa050310.60675328
89Base excision repair_Homo sapiens_hsa034100.60529909
90Cholinergic synapse_Homo sapiens_hsa047250.60414237
91Vitamin digestion and absorption_Homo sapiens_hsa049770.59781066
92Adherens junction_Homo sapiens_hsa045200.58638822
93Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.58569567
94HTLV-I infection_Homo sapiens_hsa051660.57586518
95Melanoma_Homo sapiens_hsa052180.57371874
96Rap1 signaling pathway_Homo sapiens_hsa040150.56314204
97Sulfur relay system_Homo sapiens_hsa041220.55598453
98Arachidonic acid metabolism_Homo sapiens_hsa005900.54132677
99Phagosome_Homo sapiens_hsa041450.53703792
100Aldosterone synthesis and secretion_Homo sapiens_hsa049250.53454907
101Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.52756811
102Caffeine metabolism_Homo sapiens_hsa002320.49439203
103Selenocompound metabolism_Homo sapiens_hsa004500.49139906
104Renin secretion_Homo sapiens_hsa049240.48896799
105Salivary secretion_Homo sapiens_hsa049700.45357695
106Nitrogen metabolism_Homo sapiens_hsa009100.44039231
107Antigen processing and presentation_Homo sapiens_hsa046120.43995805
108Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.43962859
109Circadian rhythm_Homo sapiens_hsa047100.43126851
110Dilated cardiomyopathy_Homo sapiens_hsa054140.42974907
111Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.42844660
112ECM-receptor interaction_Homo sapiens_hsa045120.42818128
113Viral myocarditis_Homo sapiens_hsa054160.42546860
114Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.40215041
115Gap junction_Homo sapiens_hsa045400.37825396
116Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.37667108
117Olfactory transduction_Homo sapiens_hsa047400.37593436
118Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.37383859
119Glutathione metabolism_Homo sapiens_hsa004800.37167466
120Tyrosine metabolism_Homo sapiens_hsa003500.36885087
121Prion diseases_Homo sapiens_hsa050200.36472389
122Oocyte meiosis_Homo sapiens_hsa041140.35435585
123Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.34721526
124Thyroid hormone synthesis_Homo sapiens_hsa049180.34574960
125Long-term depression_Homo sapiens_hsa047300.34563784
126Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.33975940
127Synaptic vesicle cycle_Homo sapiens_hsa047210.33816621
128Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.33768047
129Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.33365848
130Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.33214552
131Histidine metabolism_Homo sapiens_hsa003400.33092440
132Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.31836912
133ABC transporters_Homo sapiens_hsa020100.31802566
134Ras signaling pathway_Homo sapiens_hsa040140.31329650
135Colorectal cancer_Homo sapiens_hsa052100.30051893
136Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.29961002
137FoxO signaling pathway_Homo sapiens_hsa040680.29805419
138Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.29796897
139Fatty acid metabolism_Homo sapiens_hsa012120.29732146
140Calcium signaling pathway_Homo sapiens_hsa040200.29091275

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