DMTF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a transcription factor that contains a cyclin D-binding domain, three central Myb-like repeats, and two flanking acidic transactivation domains at the N- and C-termini. The encoded protein is induced by the oncogenic Ras signaling pathway and functions as a tumor suppressor by activating the transcription of ARF and thus the ARF-p53 pathway to arrest cell growth or induce apoptosis. It also activates the transcription of aminopeptidase N and may play a role in hematopoietic cell differentiation. The transcriptional activity of this protein is regulated by binding of D-cyclins. This gene is hemizygously deleted in approximately 40% of human non-small-cell lung cancer and is a potential prognostic and gene-therapy target for non-small-cell lung cancer. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cytoplasmic mRNA processing body assembly (GO:0033962)6.59671882
2synaptic vesicle endocytosis (GO:0048488)5.21922070
3positive regulation of DNA-dependent DNA replication (GO:2000105)4.94829224
4positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)4.62252167
5regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)4.62252167
6regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)4.22753961
7positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO4.22753961
8phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)4.08239417
9positive regulation of mRNA processing (GO:0050685)4.01352674
10centriole replication (GO:0007099)3.98639675
11microtubule anchoring (GO:0034453)3.97658381
12monoubiquitinated protein deubiquitination (GO:0035520)3.85781977
13positive regulation of mRNA 3-end processing (GO:0031442)3.76461679
14replicative senescence (GO:0090399)3.70929811
15positive regulation of developmental pigmentation (GO:0048087)3.69905857
16establishment of protein localization to Golgi (GO:0072600)3.68965285
17regulation of pigment cell differentiation (GO:0050932)3.67528801
18histone H3-K9 modification (GO:0061647)3.54307460
19neural tube formation (GO:0001841)3.52257624
20positive regulation of mRNA catabolic process (GO:0061014)3.48946686
21regulation of mRNA 3-end processing (GO:0031440)3.47673631
22positive regulation of mRNA metabolic process (GO:1903313)3.45353280
23nuclear pore complex assembly (GO:0051292)3.38414756
24histone H3-K4 trimethylation (GO:0080182)3.37109493
25negative regulation of DNA recombination (GO:0045910)3.30448338
26regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.29953622
27startle response (GO:0001964)3.24847466
28histone mRNA catabolic process (GO:0071044)3.22467447
29protein targeting to Golgi (GO:0000042)3.20390062
30mitotic sister chromatid cohesion (GO:0007064)3.17531025
31pre-miRNA processing (GO:0031054)3.14109963
32histone deubiquitination (GO:0016578)3.12165123
33histone H3-K36 demethylation (GO:0070544)3.09735304
34regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.08974514
35mRNA splice site selection (GO:0006376)3.08786049
36negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.08302402
37negative regulation of translation, ncRNA-mediated (GO:0040033)3.08302402
38regulation of translation, ncRNA-mediated (GO:0045974)3.08302402
39peptidyl-lysine methylation (GO:0018022)3.04341565
40synaptic transmission, glutamatergic (GO:0035249)3.04182074
41interkinetic nuclear migration (GO:0022027)3.02274925
42ionotropic glutamate receptor signaling pathway (GO:0035235)3.02004035
43negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.99940958
44DNA double-strand break processing (GO:0000729)2.99298079
45histone H2A acetylation (GO:0043968)2.99295575
46retrograde transport, vesicle recycling within Golgi (GO:0000301)2.98985148
47activated T cell proliferation (GO:0050798)2.98672890
48rRNA catabolic process (GO:0016075)2.96230515
49regulation of histone H3-K9 methylation (GO:0051570)2.92364061
50regulation of mRNA catabolic process (GO:0061013)2.91432232
51maintenance of protein location in nucleus (GO:0051457)2.89912404
52negative regulation of neurotransmitter secretion (GO:0046929)2.89349293
53N-terminal protein amino acid acetylation (GO:0006474)2.88820130
54cerebral cortex radially oriented cell migration (GO:0021799)2.88692536
55regulation of telomere maintenance (GO:0032204)2.85099078
56negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.84194840
57negative regulation of DNA-dependent DNA replication (GO:2000104)2.83309310
58nucleus localization (GO:0051647)2.81203612
59attachment of spindle microtubules to kinetochore (GO:0008608)2.81009189
60cellular response to ethanol (GO:0071361)2.80847435
61microtubule nucleation (GO:0007020)2.79888468
62protein targeting to lysosome (GO:0006622)2.77149930
63establishment of protein localization to vacuole (GO:0072666)2.77149930
64protein targeting to vacuole (GO:0006623)2.77149930
65stress granule assembly (GO:0034063)2.76935409
66mechanosensory behavior (GO:0007638)2.76874048
67regulation of helicase activity (GO:0051095)2.74157932
68regulation of short-term neuronal synaptic plasticity (GO:0048172)2.73849934
69histone H4-K16 acetylation (GO:0043984)2.69199781
70regulation of RNA export from nucleus (GO:0046831)2.68315779
71nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.67636004
72double-strand break repair via homologous recombination (GO:0000724)2.66884679
73replication fork processing (GO:0031297)2.66049081
74recombinational repair (GO:0000725)2.64190069
75RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.62335337
76regulation of mRNA processing (GO:0050684)2.60553107
77peptidyl-lysine trimethylation (GO:0018023)2.60340620
78microtubule organizing center organization (GO:0031023)2.58295854
79sister chromatid cohesion (GO:0007062)2.58222451
80protein K48-linked deubiquitination (GO:0071108)2.57909487
81regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.57280141
82regulation of DNA endoreduplication (GO:0032875)2.56580384
83nonmotile primary cilium assembly (GO:0035058)2.56119934
84negative regulation of neurotransmitter transport (GO:0051589)2.55713617
85dentate gyrus development (GO:0021542)2.55105665
86reciprocal meiotic recombination (GO:0007131)2.54710299
87reciprocal DNA recombination (GO:0035825)2.54710299
88protein localization to microtubule cytoskeleton (GO:0072698)2.53948323
89neuron-neuron synaptic transmission (GO:0007270)2.53616876
90DNA topological change (GO:0006265)2.52674478
91regulation of centriole replication (GO:0046599)2.52099950
92regulation of glutamate receptor signaling pathway (GO:1900449)2.49534733
93cerebellar Purkinje cell differentiation (GO:0021702)2.49279336
94regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.48937254
95regulation of mitotic spindle checkpoint (GO:1903504)2.48937254
96regulation of mRNA splicing, via spliceosome (GO:0048024)2.48900669
97positive regulation of granulocyte differentiation (GO:0030854)2.48491262
98limb development (GO:0060173)2.47597929
99appendage development (GO:0048736)2.47597929
100cellular response to gamma radiation (GO:0071480)2.47517683
101sister chromatid segregation (GO:0000819)2.47461062
102V(D)J recombination (GO:0033151)2.47300971
103central nervous system neuron axonogenesis (GO:0021955)2.47220622
104protein localization to Golgi apparatus (GO:0034067)2.47019004
105positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.46563171
106glutamate receptor signaling pathway (GO:0007215)2.46554033
107cilium or flagellum-dependent cell motility (GO:0001539)2.46414568
108DNA integration (GO:0015074)2.45956189
109epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.45537498
110histone lysine demethylation (GO:0070076)2.43926710
111centriole assembly (GO:0098534)2.43669638
112presynaptic membrane assembly (GO:0097105)2.43570681
113ncRNA catabolic process (GO:0034661)2.43338657
114regulation of histone H3-K27 methylation (GO:0061085)2.43039343
115neuron fate determination (GO:0048664)2.42360979
116protein prenylation (GO:0018342)2.42328805
117prenylation (GO:0097354)2.42328805
118histone H3-K4 methylation (GO:0051568)2.42251459
119regulation of nuclear cell cycle DNA replication (GO:0033262)2.41515787
120centrosome organization (GO:0051297)2.40824493
121regulation of synapse maturation (GO:0090128)2.39775217
122kinetochore organization (GO:0051383)2.39713743
123retinal ganglion cell axon guidance (GO:0031290)2.38762048
124histone H3-K9 methylation (GO:0051567)2.37523574
125N-terminal protein amino acid modification (GO:0031365)2.37415587
126histone H4 acetylation (GO:0043967)2.37408405
127positive regulation of dendritic spine morphogenesis (GO:0061003)2.36872781
128neuron cell-cell adhesion (GO:0007158)2.36871752
129establishment of nucleus localization (GO:0040023)2.36137219
130regulation of synaptic transmission, glutamatergic (GO:0051966)2.36014646
131tachykinin receptor signaling pathway (GO:0007217)2.35390084
132regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.35352752
133central nervous system projection neuron axonogenesis (GO:0021952)2.34237796
134regulation of DNA methylation (GO:0044030)2.33910506
135histone H3-K9 demethylation (GO:0033169)2.33019049
136regulation of mRNA metabolic process (GO:1903311)2.32996582
137snRNA transcription (GO:0009301)2.32561403
138head development (GO:0060322)2.31920661
139glycosphingolipid biosynthetic process (GO:0006688)2.31681478
140protein K11-linked deubiquitination (GO:0035871)2.31444726
141serotonin receptor signaling pathway (GO:0007210)2.30813950
142histone methylation (GO:0016571)2.30784191
143alternative mRNA splicing, via spliceosome (GO:0000380)2.30352770
144regulation of gene expression by genetic imprinting (GO:0006349)2.29777966
145pore complex assembly (GO:0046931)2.29749568
146regulation of DNA-dependent DNA replication (GO:0090329)2.29600896
147negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.28990305
148negative regulation of cell killing (GO:0031342)2.28990305
149neuron recognition (GO:0008038)2.27672551
150response to pheromone (GO:0019236)2.26837511
151telomere maintenance via telomerase (GO:0007004)2.24093092
152urinary tract smooth muscle contraction (GO:0014848)2.22718759
153olfactory bulb development (GO:0021772)2.20940084
154somatic diversification of immune receptors via somatic mutation (GO:0002566)2.18706545
155somatic hypermutation of immunoglobulin genes (GO:0016446)2.18706545
156kinetochore assembly (GO:0051382)2.14621213
157phosphorylated carbohydrate dephosphorylation (GO:0046838)2.14385815
158inositol phosphate dephosphorylation (GO:0046855)2.14385815
159microtubule depolymerization (GO:0007019)2.13958492
160presynaptic membrane organization (GO:0097090)2.13344839
161histone lysine methylation (GO:0034968)2.13072691
162regulation of meiosis I (GO:0060631)2.12062889
163positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.11645015
164positive regulation of cell cycle checkpoint (GO:1901978)2.11399540
165response to prostaglandin E (GO:0034695)2.11002379
166nuclear pore organization (GO:0006999)2.09905402
167protein localization to cytoskeleton (GO:0044380)2.09612568
168cellular response to interleukin-15 (GO:0071350)2.09437928

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.56767156
2SALL1_21062744_ChIP-ChIP_HESCs_Human3.24753839
3RBPJ_22232070_ChIP-Seq_NCS_Mouse3.14411199
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.09615284
5EZH2_22144423_ChIP-Seq_EOC_Human2.82388215
6ZNF274_21170338_ChIP-Seq_K562_Hela2.57569618
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.52500061
8* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.45758017
9EWS_26573619_Chip-Seq_HEK293_Human2.41581459
10CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.38823022
11TAF15_26573619_Chip-Seq_HEK293_Human2.37237813
12CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.33775991
13FUS_26573619_Chip-Seq_HEK293_Human2.32800459
14SMAD_19615063_ChIP-ChIP_OVARY_Human2.32787776
15SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.32172276
16TP63_19390658_ChIP-ChIP_HaCaT_Human2.23106413
17FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.18710245
18* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.15484714
19FLI1_27457419_Chip-Seq_LIVER_Mouse2.13456536
20PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.10751889
21ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.01000354
22P300_19829295_ChIP-Seq_ESCs_Human1.93764101
23BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.93556494
24HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.91244872
25OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.86017953
26* E2F4_17652178_ChIP-ChIP_JURKAT_Human1.77877759
27CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.75672804
28* ER_23166858_ChIP-Seq_MCF-7_Human1.68912476
29E2F7_22180533_ChIP-Seq_HELA_Human1.66891290
30VDR_22108803_ChIP-Seq_LS180_Human1.66538692
31IRF1_19129219_ChIP-ChIP_H3396_Human1.65686846
32TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.62469804
33PCGF2_27294783_Chip-Seq_ESCs_Mouse1.61465489
34NANOG_18555785_Chip-Seq_ESCs_Mouse1.58703332
35POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.56132413
36TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.56132413
37* STAT3_23295773_ChIP-Seq_U87_Human1.55221690
38SMAD4_21799915_ChIP-Seq_A2780_Human1.54957906
39AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.51960892
40PCGF2_27294783_Chip-Seq_NPCs_Mouse1.51934922
41PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.51505755
42TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.46191215
43E2F1_18555785_Chip-Seq_ESCs_Mouse1.45753123
44YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.44759781
45IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.43060198
46CBP_20019798_ChIP-Seq_JUKART_Human1.43060198
47VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.41338274
48AR_21572438_ChIP-Seq_LNCaP_Human1.40000507
49CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.39421565
50SMAD3_21741376_ChIP-Seq_EPCs_Human1.38704772
51POU5F1_16153702_ChIP-ChIP_HESCs_Human1.38429342
52TCF4_23295773_ChIP-Seq_U87_Human1.37816111
53EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.37724701
54IGF1R_20145208_ChIP-Seq_DFB_Human1.36487620
55SUZ12_27294783_Chip-Seq_NPCs_Mouse1.35205474
56CTBP2_25329375_ChIP-Seq_LNCAP_Human1.34561719
57STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.34189292
58CMYC_18555785_Chip-Seq_ESCs_Mouse1.34124676
59SUZ12_18555785_Chip-Seq_ESCs_Mouse1.33427653
60NFE2_27457419_Chip-Seq_LIVER_Mouse1.33271967
61CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31412235
62SOX9_26525672_Chip-Seq_HEART_Mouse1.30725888
63TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.29788840
64P53_22387025_ChIP-Seq_ESCs_Mouse1.29655748
65TOP2B_26459242_ChIP-Seq_MCF-7_Human1.29027766
66ARNT_22903824_ChIP-Seq_MCF-7_Human1.27916985
67MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.26648945
68BCAT_22108803_ChIP-Seq_LS180_Human1.26466064
69RNF2_27304074_Chip-Seq_NSC_Mouse1.25440757
70PIAS1_25552417_ChIP-Seq_VCAP_Human1.24320359
71EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.23476533
72CTBP1_25329375_ChIP-Seq_LNCAP_Human1.22896197
73SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22100519
74EZH2_27294783_Chip-Seq_NPCs_Mouse1.22025456
75FLI1_21867929_ChIP-Seq_TH2_Mouse1.18128860
76ZNF217_24962896_ChIP-Seq_MCF-7_Human1.17555594
77NMYC_18555785_Chip-Seq_ESCs_Mouse1.16864329
78STAT3_18555785_Chip-Seq_ESCs_Mouse1.16619880
79FOXM1_23109430_ChIP-Seq_U2OS_Human1.16237545
80CDX2_19796622_ChIP-Seq_MESCs_Mouse1.15979921
81GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15308957
82P300_18555785_Chip-Seq_ESCs_Mouse1.14421411
83LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14303938
84CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.14285968
85KLF5_20875108_ChIP-Seq_MESCs_Mouse1.13543027
86OCT4_21477851_ChIP-Seq_ESCs_Mouse1.10892785
87AR_25329375_ChIP-Seq_VCAP_Human1.10131128
88* RUNX2_22187159_ChIP-Seq_PCA_Human1.09608241
89JUN_21703547_ChIP-Seq_K562_Human1.09054504
90BMI1_23680149_ChIP-Seq_NPCS_Mouse1.08613794
91CRX_20693478_ChIP-Seq_RETINA_Mouse1.07411164
92WT1_19549856_ChIP-ChIP_CCG9911_Human1.06727578
93MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.06313707
94REST_21632747_ChIP-Seq_MESCs_Mouse1.06295949
95RUNX1_27457419_Chip-Seq_LIVER_Mouse1.06207757
96CBX2_27304074_Chip-Seq_ESCs_Mouse1.06093391
97PADI4_21655091_ChIP-ChIP_MCF-7_Human1.06003797
98AHR_22903824_ChIP-Seq_MCF-7_Human1.05624235
99TP53_16413492_ChIP-PET_HCT116_Human1.05336720
100TCF4_22108803_ChIP-Seq_LS180_Human1.04972556
101STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.04686079
102TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.04517331
103FOXM1_26456572_ChIP-Seq_MCF-7_Human1.04330361
104SOX2_18555785_Chip-Seq_ESCs_Mouse1.03840710
105DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.03387096
106* SOX2_21211035_ChIP-Seq_LN229_Gbm1.03025244
107TAL1_26923725_Chip-Seq_HPCs_Mouse1.02565736
108PRDM14_20953172_ChIP-Seq_ESCs_Human1.02511625
109* ELK1_19687146_ChIP-ChIP_HELA_Human1.02211454
110CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.01914840
111SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.01867353
112KDM2B_26808549_Chip-Seq_REH_Human1.01327164
113OCT4_18555785_Chip-Seq_ESCs_Mouse1.01296546
114NR3C1_21868756_ChIP-Seq_MCF10A_Human1.00918034
115KLF4_18555785_Chip-Seq_ESCs_Mouse1.00590529
116POU3F1_26484290_ChIP-Seq_ESCss_Mouse1.00508303
117MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.00488943
118YAP1_20516196_ChIP-Seq_MESCs_Mouse0.99524473
119NOTCH1_21737748_ChIP-Seq_TLL_Human0.99242677
120CTCF_18555785_Chip-Seq_ESCs_Mouse0.98017796
121* RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.97195245
122SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.97115387
123TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.97035326
124STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.96957933
125RUNX_20019798_ChIP-Seq_JUKART_Human0.96918992
126PU1_27457419_Chip-Seq_LIVER_Mouse0.96430197
127PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.95684526
128UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.94863779
129TBX3_20139965_ChIP-Seq_ESCs_Mouse0.93436538

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode3.71119813
2MP0008057_abnormal_DNA_replication3.16325900
3MP0004859_abnormal_synaptic_plasticity2.69636333
4MP0003880_abnormal_central_pattern2.48495476
5MP0001188_hyperpigmentation2.45881438
6MP0003787_abnormal_imprinting2.45222884
7MP0008877_abnormal_DNA_methylation2.44194577
8MP0002735_abnormal_chemical_nociception2.36561907
9MP0005499_abnormal_olfactory_system2.21567685
10MP0005394_taste/olfaction_phenotype2.21567685
11MP0008789_abnormal_olfactory_epithelium2.16877579
12MP0000778_abnormal_nervous_system2.15797818
13MP0003890_abnormal_embryonic-extraembry2.10755951
14MP0004885_abnormal_endolymph2.05006610
15MP0003635_abnormal_synaptic_transmissio1.98457306
16MP0003567_abnormal_fetal_cardiomyocyte1.95653337
17MP0002396_abnormal_hematopoietic_system1.88582713
18MP0000537_abnormal_urethra_morphology1.87897185
19MP0010386_abnormal_urinary_bladder1.85149832
20MP0006054_spinal_hemorrhage1.84863094
21MP0002938_white_spotting1.84621588
22MP0008007_abnormal_cellular_replicative1.82036563
23MP0002572_abnormal_emotion/affect_behav1.80700010
24MP0002063_abnormal_learning/memory/cond1.77401121
25MP0000383_abnormal_hair_follicle1.76378121
26MP0010094_abnormal_chromosome_stability1.71185712
27MP0008058_abnormal_DNA_repair1.68225216
28MP0003121_genomic_imprinting1.65595150
29MP0001486_abnormal_startle_reflex1.63924460
30MP0002736_abnormal_nociception_after1.62458937
31MP0009046_muscle_twitch1.60934655
32MP0005386_behavior/neurological_phenoty1.59540007
33MP0004924_abnormal_behavior1.59540007
34MP0009745_abnormal_behavioral_response1.59190921
35MP0002272_abnormal_nervous_system1.57764719
36MP0003111_abnormal_nucleus_morphology1.52555714
37MP0003183_abnormal_peptide_metabolism1.51730547
38MP0001968_abnormal_touch/_nociception1.49682610
39MP0000569_abnormal_digit_pigmentation1.46272113
40* MP0002064_seizures1.45706492
41MP0005645_abnormal_hypothalamus_physiol1.43522921
42MP0000427_abnormal_hair_cycle1.41987516
43MP0002184_abnormal_innervation1.35835766
44MP0005409_darkened_coat_color1.32425463
45MP0002234_abnormal_pharynx_morphology1.32308023
46MP0002557_abnormal_social/conspecific_i1.31684877
47MP0000631_abnormal_neuroendocrine_gland1.30610460
48MP0004197_abnormal_fetal_growth/weight/1.28389658
49MP0006072_abnormal_retinal_apoptosis1.26097963
50MP0002102_abnormal_ear_morphology1.25566500
51* MP0002067_abnormal_sensory_capabilities1.24347624
52MP0003763_abnormal_thymus_physiology1.23558982
53MP0002751_abnormal_autonomic_nervous1.23380818
54MP0003077_abnormal_cell_cycle1.22582541
55MP0003861_abnormal_nervous_system1.21892438
56MP0002009_preneoplasia1.20894957
57MP0005171_absent_coat_pigmentation1.20121150
58MP0009697_abnormal_copulation1.19514199
59MP0005174_abnormal_tail_pigmentation1.18472625
60MP0003221_abnormal_cardiomyocyte_apopto1.14292463
61MP0000015_abnormal_ear_pigmentation1.13350056
62MP0002734_abnormal_mechanical_nocicepti1.11976969
63MP0001177_atelectasis1.10516681
64MP0001984_abnormal_olfaction1.08912448
65MP0000428_abnormal_craniofacial_morphol1.08279862
66MP0001485_abnormal_pinna_reflex1.07857390
67* MP0000516_abnormal_urinary_system1.07792760
68* MP0005367_renal/urinary_system_phenotyp1.07792760
69MP0004133_heterotaxia1.07200852
70MP0010678_abnormal_skin_adnexa1.05633024
71MP0005423_abnormal_somatic_nervous1.04775762
72MP0002882_abnormal_neuron_morphology1.04370256
73MP0002152_abnormal_brain_morphology1.03543302
74MP0004270_analgesia1.02710315
75MP0002928_abnormal_bile_duct1.02556880
76* MP0000703_abnormal_thymus_morphology0.99570576
77MP0001529_abnormal_vocalization0.98520201
78MP0002084_abnormal_developmental_patter0.97780714
79MP0001986_abnormal_taste_sensitivity0.96954508
80MP0001501_abnormal_sleep_pattern0.96932881
81MP0003385_abnormal_body_wall0.95396445
82MP0004215_abnormal_myocardial_fiber0.95147159
83MP0004811_abnormal_neuron_physiology0.94587779
84MP0005646_abnormal_pituitary_gland0.94452259
85MP0004742_abnormal_vestibular_system0.93704307
86MP0002177_abnormal_outer_ear0.92806070
87MP0003122_maternal_imprinting0.92034751
88MP0004043_abnormal_pH_regulation0.90180629
89MP0001963_abnormal_hearing_physiology0.89319571
90MP0000566_synostosis0.89170897
91MP0004808_abnormal_hematopoietic_stem0.88696311
92MP0003937_abnormal_limbs/digits/tail_de0.88580848
93MP0002088_abnormal_embryonic_growth/wei0.87867727
94MP0005551_abnormal_eye_electrophysiolog0.87823914
95MP0003935_abnormal_craniofacial_develop0.87293495
96MP0006276_abnormal_autonomic_nervous0.87119360
97MP0000026_abnormal_inner_ear0.86468341
98MP0005671_abnormal_response_to0.86212060
99MP0001929_abnormal_gametogenesis0.85209190
100MP0001293_anophthalmia0.85150283
101MP0009703_decreased_birth_body0.84855871
102MP0003195_calcinosis0.84024895
103MP0002233_abnormal_nose_morphology0.83844459
104MP0003786_premature_aging0.83702759
105MP0001672_abnormal_embryogenesis/_devel0.83402941
106MP0005380_embryogenesis_phenotype0.83402941
107MP0001440_abnormal_grooming_behavior0.82831988
108MP0003984_embryonic_growth_retardation0.82023405
109MP0001800_abnormal_humoral_immune0.81828257
110MP0003755_abnormal_palate_morphology0.81127162
111MP0002752_abnormal_somatic_nervous0.81094788
112* MP0010307_abnormal_tumor_latency0.80610477
113MP0003868_abnormal_feces_composition0.80481515
114MP0003943_abnormal_hepatobiliary_system0.78969337
115MP0000955_abnormal_spinal_cord0.78548336
116MP0008995_early_reproductive_senescence0.78387454
117MP0004484_altered_response_of0.77361443
118MP0001502_abnormal_circadian_rhythm0.76715795
119MP0002168_other_aberrant_phenotype0.75153498
120MP0002095_abnormal_skin_pigmentation0.74808771
121MP0003941_abnormal_skin_development0.74640825
122MP0001286_abnormal_eye_development0.74143401
123MP0001697_abnormal_embryo_size0.74078208
124MP0000647_abnormal_sebaceous_gland0.73904650
125MP0008961_abnormal_basal_metabolism0.73756710
126MP0003938_abnormal_ear_development0.73532744
127MP0005220_abnormal_exocrine_pancreas0.73324204
128MP0005391_vision/eye_phenotype0.73044065
129MP0003123_paternal_imprinting0.72445143
130MP0003119_abnormal_digestive_system0.72152140
131MP0004142_abnormal_muscle_tone0.71337201
132MP0000432_abnormal_head_morphology0.71333181
133MP0001905_abnormal_dopamine_level0.70906281
134MP0001970_abnormal_pain_threshold0.69732542
135MP0005075_abnormal_melanosome_morpholog0.69172859
136MP0002081_perinatal_lethality0.69133518
137MP0005253_abnormal_eye_physiology0.68972526
138MP0000534_abnormal_ureter_morphology0.68846070
139MP0001299_abnormal_eye_distance/0.68487649
140MP0005195_abnormal_posterior_eye0.68320509
141MP0004134_abnormal_chest_morphology0.67350690
142* MP0010770_preweaning_lethality0.67170133
143* MP0002082_postnatal_lethality0.67170133
144MP0004147_increased_porphyrin_level0.66904843

Predicted human phenotypes

RankGene SetZ-score
1Long nose (HP:0003189)3.27369131
2Abnormal hair whorl (HP:0010721)3.08233233
3Chromosomal breakage induced by crosslinking agents (HP:0003221)3.06434790
4Febrile seizures (HP:0002373)3.03894759
5Protruding tongue (HP:0010808)3.02089508
6Focal motor seizures (HP:0011153)2.89138068
7Volvulus (HP:0002580)2.85111592
8Chromsome breakage (HP:0040012)2.84639409
9B lymphocytopenia (HP:0010976)2.77722141
10Stomach cancer (HP:0012126)2.77298623
11Abnormality of the labia minora (HP:0012880)2.73021240
12Abnormality of B cell number (HP:0010975)2.70530610
13Severe combined immunodeficiency (HP:0004430)2.57976257
14Pancreatic fibrosis (HP:0100732)2.56059709
15Papillary thyroid carcinoma (HP:0002895)2.55720853
16Gastroesophageal reflux (HP:0002020)2.54988233
17Absent speech (HP:0001344)2.51940651
18Hyperventilation (HP:0002883)2.47679958
19Acute myeloid leukemia (HP:0004808)2.47587835
20Renal cortical cysts (HP:0000803)2.46343485
21Nephroblastoma (Wilms tumor) (HP:0002667)2.46184548
22Panhypogammaglobulinemia (HP:0003139)2.42475519
23Molar tooth sign on MRI (HP:0002419)2.41550787
24Abnormality of midbrain morphology (HP:0002418)2.41550787
25Embryonal renal neoplasm (HP:0011794)2.40855063
26Abnormality of the fingertips (HP:0001211)2.39576458
27Drooling (HP:0002307)2.39440740
28Excessive salivation (HP:0003781)2.39440740
29Poor eye contact (HP:0000817)2.37452274
30Abnormality of the astrocytes (HP:0100707)2.36209302
31Astrocytoma (HP:0009592)2.36209302
32Tented upper lip vermilion (HP:0010804)2.35383671
33Scrotal hypoplasia (HP:0000046)2.33906758
34Abnormality of the renal cortex (HP:0011035)2.33508259
35Fair hair (HP:0002286)2.32526479
36Glioma (HP:0009733)2.32202552
37Broad-based gait (HP:0002136)2.31922596
38Cystic hygroma (HP:0000476)2.31413592
39Aqueductal stenosis (HP:0002410)2.28552716
40Genital tract atresia (HP:0001827)2.27323812
41Epileptic encephalopathy (HP:0200134)2.26149460
42True hermaphroditism (HP:0010459)2.25407134
43Vaginal atresia (HP:0000148)2.23353856
44Occipital encephalocele (HP:0002085)2.19033365
45Pancreatic cysts (HP:0001737)2.17586074
46Aplasia/Hypoplasia of the uvula (HP:0010293)2.16136410
47Abnormality of the ischium (HP:0003174)2.14957054
48Combined immunodeficiency (HP:0005387)2.14210260
49Widely spaced teeth (HP:0000687)2.13920723
50Tubulointerstitial nephritis (HP:0001970)2.13832990
51Nephronophthisis (HP:0000090)2.12583397
52Prominent nose (HP:0000448)2.09926535
53Papilledema (HP:0001085)2.09868528
54Poor coordination (HP:0002370)2.08650373
55Medulloblastoma (HP:0002885)2.08229027
56Gaze-evoked nystagmus (HP:0000640)2.07709310
57Thyroiditis (HP:0100646)2.07229470
58Meckel diverticulum (HP:0002245)2.04781039
59Clitoromegaly (HP:0000057)2.01849111
60Cupped ear (HP:0000378)2.01542092
61Ependymoma (HP:0002888)2.01521014
62Atonic seizures (HP:0010819)2.00387037
63Thin upper lip vermilion (HP:0000219)2.00286611
64Abnormality of the preputium (HP:0100587)1.99350905
65Aplasia/Hypoplasia of the sternum (HP:0006714)1.99000841
66Rhabdomyosarcoma (HP:0002859)1.95414741
67Renal hypoplasia (HP:0000089)1.93753360
68Blue irides (HP:0000635)1.92178352
69Abnormality of the ileum (HP:0001549)1.91920314
70Ectopic kidney (HP:0000086)1.91071315
71Midline defect of the nose (HP:0004122)1.90986420
72Abnormality of the metopic suture (HP:0005556)1.88704539
73Intestinal atresia (HP:0011100)1.88537930
74Abnormality of chromosome stability (HP:0003220)1.88015170
75Genetic anticipation (HP:0003743)1.87744286
76Hypoplastic ischia (HP:0003175)1.86556962
77Sandal gap (HP:0001852)1.86388211
78Neoplasm of the adrenal cortex (HP:0100641)1.85220092
79Chronic hepatic failure (HP:0100626)1.85179466
80Sloping forehead (HP:0000340)1.84908190
81Prominent metopic ridge (HP:0005487)1.84824753
82Absent eyebrow (HP:0002223)1.84313509
83Abnormality of salivation (HP:0100755)1.84226680
84Micropenis (HP:0000054)1.82353541
85Abnormality of the renal medulla (HP:0100957)1.82282142
86Clubbing of toes (HP:0100760)1.82225427
87Progressive cerebellar ataxia (HP:0002073)1.82213257
88Nephrogenic diabetes insipidus (HP:0009806)1.79484788
89Trigonocephaly (HP:0000243)1.78321436
90Abnormality of T cell number (HP:0011839)1.78204257
91Generalized hypopigmentation of hair (HP:0011358)1.77841158
92Neoplasm of striated muscle (HP:0009728)1.77217860
93Anophthalmia (HP:0000528)1.77166940
94Thyroid carcinoma (HP:0002890)1.76908932
95Prominent supraorbital ridges (HP:0000336)1.76407574
96Hypotelorism (HP:0000601)1.76360422
97Myelodysplasia (HP:0002863)1.75587362
98Preaxial hand polydactyly (HP:0001177)1.75225046
99Hepatoblastoma (HP:0002884)1.74979655
100Biliary tract neoplasm (HP:0100574)1.73915339
10111 pairs of ribs (HP:0000878)1.73544630
102Astigmatism (HP:0000483)1.73511257
103Hypoplasia of the thymus (HP:0000778)1.73475165
104Macrotia (HP:0000400)1.72830587
105Shoulder girdle muscle weakness (HP:0003547)1.72802178
106Abnormal social behavior (HP:0012433)1.71749935
107Impaired social interactions (HP:0000735)1.71749935
108Postural instability (HP:0002172)1.71360077
109Impaired smooth pursuit (HP:0007772)1.71074773
110Optic nerve coloboma (HP:0000588)1.70983612
111Medial flaring of the eyebrow (HP:0010747)1.70895547
112Abnormality of secondary sexual hair (HP:0009888)1.70893526
113Abnormality of the axillary hair (HP:0100134)1.70893526
114Gonadotropin excess (HP:0000837)1.70882345
115Cutis marmorata (HP:0000965)1.70271983
116Neoplasm of the small intestine (HP:0100833)1.69230896
117Acute lymphatic leukemia (HP:0006721)1.69123218
118Abnormality of the carotid arteries (HP:0005344)1.69019946
119Abnormality of the duodenum (HP:0002246)1.68263798
120Bifid tongue (HP:0010297)1.67485498
121Gastrointestinal atresia (HP:0002589)1.67006648
122Cutaneous finger syndactyly (HP:0010554)1.66686450
123Submucous cleft hard palate (HP:0000176)1.66210768
124Septo-optic dysplasia (HP:0100842)1.66075801
125Absent frontal sinuses (HP:0002688)1.65937082
126Truncal obesity (HP:0001956)1.65887528
127Short foot (HP:0001773)1.65681631
128Neoplasm of the tracheobronchial system (HP:0100552)1.65605664
129Supernumerary spleens (HP:0009799)1.65202584
130Absent radius (HP:0003974)1.64257470
131Hypoplasia of the maxilla (HP:0000327)1.64139316
132Heterotopia (HP:0002282)1.63557443
133Aganglionic megacolon (HP:0002251)1.63319125
1342-3 toe syndactyly (HP:0004691)1.63152060
135Aplasia/Hypoplasia of the tongue (HP:0010295)1.62997288
136Hip dysplasia (HP:0001385)1.62910931
137Colon cancer (HP:0003003)1.62387510
138Neoplasm of the oral cavity (HP:0100649)1.60712417
139Exotropia (HP:0000577)1.60377625
140Autism (HP:0000717)1.60310797
141Abnormality of the antihelix (HP:0009738)1.60209385
142Gait imbalance (HP:0002141)1.59411214
143Abnormality of the nasal septum (HP:0000419)1.59166491
144Deeply set eye (HP:0000490)1.58868796
145Narrow forehead (HP:0000341)1.55417572
146Oligodactyly (hands) (HP:0001180)1.54084025
147Congenital primary aphakia (HP:0007707)1.52717250
148T lymphocytopenia (HP:0005403)1.52191249
149Postaxial foot polydactyly (HP:0001830)1.51368532
150Bone marrow hypocellularity (HP:0005528)1.50658800
151Anal stenosis (HP:0002025)1.49086004

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BMPR1B3.38032944
2PNCK3.24523082
3SRPK12.60682581
4CASK2.50308271
5AKT32.49673218
6MAP2K72.43016351
7NTRK32.42693273
8CDK32.32306686
9MAP3K42.24129159
10STK162.13419141
11LATS12.12072465
12TSSK61.96239569
13YES11.95300798
14BRD41.87466236
15CAMK1G1.84171632
16SGK21.83875319
17ERBB31.75501712
18NUAK11.75043657
19WNK31.74569173
20EIF2AK31.72046418
21MAPK131.69798412
22TXK1.69523920
23MKNK21.62572915
24PLK31.62110907
25MAP4K11.61976588
26INSRR1.60060655
27PLK21.53055589
28NTRK21.52744716
29ADRBK21.52556011
30NLK1.46885578
31PRPF4B1.45727881
32CAMKK21.45179243
33MARK11.43907671
34TGFBR11.42949819
35MKNK11.42782702
36SIK31.39461831
37EPHA41.38143514
38TEC1.36974002
39ERBB41.32671164
40VRK11.25723789
41ACVR1B1.24961382
42BMPR21.24022347
43SGK2231.22630864
44SGK4941.22630864
45SGK31.22034450
46ZAK1.21733191
47PAK31.19682361
48CSNK1A1L1.15803592
49EIF2AK21.12227836
50WEE11.09224354
51MAP3K141.08161891
52FGFR21.07935466
53TRIM281.06362829
54MUSK1.01941351
55DYRK1A1.00153375
56RIPK40.97401731
57ATR0.97063953
58NEK60.94205322
59MAP3K100.93300554
60FLT30.87664091
61BCR0.84215197
62MELK0.84142822
63PLK40.83053219
64CCNB10.81449464
65DYRK20.81317885
66STK38L0.78786374
67CSNK1G30.77974644
68CSNK1G20.76666629
69NEK90.75215349
70FRK0.74627964
71SGK10.73185195
72ATM0.72339227
73FGFR10.72326549
74MAP3K70.71394017
75TAF10.70708958
76PBK0.69410718
77DYRK30.68449089
78TAOK30.68126271
79IRAK40.66330934
80MARK30.65347632
81CDK80.62566251
82FES0.61938281
83CHEK20.61619661
84CSNK1G10.61428155
85WNK10.61177730
86CAMK1D0.61100794
87ERBB20.59788059
88CHEK10.59103095
89RPS6KA40.58854248
90IRAK10.58402455
91BTK0.58016807
92CDK120.57217023
93NEK20.56830296
94IRAK20.56283315
95PIK3CA0.56020632
96MAPK70.53380448
97SYK0.52490190
98TTK0.52421337
99PKN10.51242963
100TNIK0.50898807
101STK390.49700563
102HCK0.48967204
103CDK10.48762240
104PRKCE0.48395576
105CDK60.48202563
106SIK20.47805540
107ITK0.46598698
108UHMK10.46574584
109CDK20.46544176
110MAPK140.44654622
111GSK3B0.44595323
112STK30.44379037
113GRK70.43449450
114MAP4K20.42629915
115PLK10.42508104
116MAPK100.42247338
117JAK10.41989467
118OXSR10.41901266
119CSNK1A10.40821197
120KSR10.40627442
121PDGFRB0.40339261
122CLK10.39906359
123EGFR0.39808443
124PRKDC0.39361118
125FGFR30.38791438
126PIK3CG0.38715306
127TYRO30.38218700
128TAOK20.37616024
129PRKCG0.36635528
130TIE10.35779886
131MAP2K40.34886956
132BRSK20.34532124
133PRKCB0.32594286
134PRKG10.32514945
135CSNK1D0.31946578
136CAMK10.29597298
137CDC70.29361716
138RPS6KA30.28922568
139MAPK80.28704610
140CDK50.27359366
141JAK30.27088471

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.80044812
2Lysine degradation_Homo sapiens_hsa003102.20470423
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.80421878
4Fanconi anemia pathway_Homo sapiens_hsa034601.77294823
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.75899108
6RNA degradation_Homo sapiens_hsa030181.73206263
7Non-homologous end-joining_Homo sapiens_hsa034501.72726721
8ABC transporters_Homo sapiens_hsa020101.69230763
9Basal transcription factors_Homo sapiens_hsa030221.65824779
10Taste transduction_Homo sapiens_hsa047421.63589222
11Glutamatergic synapse_Homo sapiens_hsa047241.61067085
12Long-term potentiation_Homo sapiens_hsa047201.58802451
13Morphine addiction_Homo sapiens_hsa050321.58028356
14mRNA surveillance pathway_Homo sapiens_hsa030151.57506385
15Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.43005007
16Selenocompound metabolism_Homo sapiens_hsa004501.40351839
17Circadian entrainment_Homo sapiens_hsa047131.39478696
18Spliceosome_Homo sapiens_hsa030401.38064383
19Amphetamine addiction_Homo sapiens_hsa050311.37515537
20Cell cycle_Homo sapiens_hsa041101.37284775
21Phototransduction_Homo sapiens_hsa047441.35937022
22Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.32989207
23Axon guidance_Homo sapiens_hsa043601.29144702
24Serotonergic synapse_Homo sapiens_hsa047261.29140540
25GABAergic synapse_Homo sapiens_hsa047271.29076728
26Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.26655991
27Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.25830646
28Olfactory transduction_Homo sapiens_hsa047401.23817349
29Dopaminergic synapse_Homo sapiens_hsa047281.22246844
30Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.19949614
31RNA polymerase_Homo sapiens_hsa030201.18407786
32RNA transport_Homo sapiens_hsa030131.18385338
33Primary immunodeficiency_Homo sapiens_hsa053401.16908730
34Mismatch repair_Homo sapiens_hsa034301.14721209
35Synaptic vesicle cycle_Homo sapiens_hsa047211.13397141
36Homologous recombination_Homo sapiens_hsa034401.12974508
37Autoimmune thyroid disease_Homo sapiens_hsa053201.07113273
38Base excision repair_Homo sapiens_hsa034101.06779280
39Colorectal cancer_Homo sapiens_hsa052101.06726373
40Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.06039182
41Long-term depression_Homo sapiens_hsa047301.05194691
42Graft-versus-host disease_Homo sapiens_hsa053321.04971905
43T cell receptor signaling pathway_Homo sapiens_hsa046601.02922305
44Type I diabetes mellitus_Homo sapiens_hsa049401.02349093
45Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.01612774
46Phosphatidylinositol signaling system_Homo sapiens_hsa040701.01290937
47Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.99563497
48Non-small cell lung cancer_Homo sapiens_hsa052230.99449534
49Nucleotide excision repair_Homo sapiens_hsa034200.97960140
50Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.97404916
51NF-kappa B signaling pathway_Homo sapiens_hsa040640.96773495
52Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.93069277
53Cocaine addiction_Homo sapiens_hsa050300.92199734
54Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.90857569
55NOD-like receptor signaling pathway_Homo sapiens_hsa046210.90796134
56MAPK signaling pathway_Homo sapiens_hsa040100.90255854
57Oocyte meiosis_Homo sapiens_hsa041140.90182264
58Cholinergic synapse_Homo sapiens_hsa047250.89878300
59Allograft rejection_Homo sapiens_hsa053300.89283684
60ErbB signaling pathway_Homo sapiens_hsa040120.88179970
61Jak-STAT signaling pathway_Homo sapiens_hsa046300.86151966
62Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.85974181
63Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.85373206
64Ether lipid metabolism_Homo sapiens_hsa005650.84559509
65Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.81205732
66Measles_Homo sapiens_hsa051620.80956609
67Transcriptional misregulation in cancer_Homo sapiens_hsa052020.80381234
68Herpes simplex infection_Homo sapiens_hsa051680.80119025
69Insulin secretion_Homo sapiens_hsa049110.79954050
70FoxO signaling pathway_Homo sapiens_hsa040680.79679970
71Epstein-Barr virus infection_Homo sapiens_hsa051690.79633264
72mTOR signaling pathway_Homo sapiens_hsa041500.78035687
73MicroRNAs in cancer_Homo sapiens_hsa052060.77992375
74Prolactin signaling pathway_Homo sapiens_hsa049170.77718118
75Propanoate metabolism_Homo sapiens_hsa006400.77029988
76Rheumatoid arthritis_Homo sapiens_hsa053230.76452756
77Alcoholism_Homo sapiens_hsa050340.76120365
78Calcium signaling pathway_Homo sapiens_hsa040200.76119584
79Chronic myeloid leukemia_Homo sapiens_hsa052200.75942402
80Intestinal immune network for IgA production_Homo sapiens_hsa046720.75844031
81Wnt signaling pathway_Homo sapiens_hsa043100.75686794
82Type II diabetes mellitus_Homo sapiens_hsa049300.74182697
83Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.73009394
84Longevity regulating pathway - mammal_Homo sapiens_hsa042110.72754764
85Renal cell carcinoma_Homo sapiens_hsa052110.71702889
86Pancreatic cancer_Homo sapiens_hsa052120.71117373
87Hematopoietic cell lineage_Homo sapiens_hsa046400.69392410
88Inositol phosphate metabolism_Homo sapiens_hsa005620.68599752
89Aldosterone synthesis and secretion_Homo sapiens_hsa049250.68598895
90DNA replication_Homo sapiens_hsa030300.67053526
91RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.66929852
92Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.66918769
93Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.65868208
94Circadian rhythm_Homo sapiens_hsa047100.65625832
95HTLV-I infection_Homo sapiens_hsa051660.65512428
96Platelet activation_Homo sapiens_hsa046110.65440011
97SNARE interactions in vesicular transport_Homo sapiens_hsa041300.63940658
98Phospholipase D signaling pathway_Homo sapiens_hsa040720.63417276
99GnRH signaling pathway_Homo sapiens_hsa049120.63075526
100Ras signaling pathway_Homo sapiens_hsa040140.62812384
101Endometrial cancer_Homo sapiens_hsa052130.62027776
102Thyroid hormone signaling pathway_Homo sapiens_hsa049190.60972028
103Choline metabolism in cancer_Homo sapiens_hsa052310.59656616
104TNF signaling pathway_Homo sapiens_hsa046680.59008859
105Neurotrophin signaling pathway_Homo sapiens_hsa047220.58879505
106Dorso-ventral axis formation_Homo sapiens_hsa043200.58407044
107Regulation of autophagy_Homo sapiens_hsa041400.57766654
108Butanoate metabolism_Homo sapiens_hsa006500.56468235
109p53 signaling pathway_Homo sapiens_hsa041150.55805826
110Prostate cancer_Homo sapiens_hsa052150.55497277
111Vibrio cholerae infection_Homo sapiens_hsa051100.54912078
112Nitrogen metabolism_Homo sapiens_hsa009100.54572522
113TGF-beta signaling pathway_Homo sapiens_hsa043500.54497299
114Melanoma_Homo sapiens_hsa052180.54359715
115Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.53515753
116Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.53343237
117cAMP signaling pathway_Homo sapiens_hsa040240.53037433
118Rap1 signaling pathway_Homo sapiens_hsa040150.52776041
119AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.52599924
120Chemokine signaling pathway_Homo sapiens_hsa040620.52431535
121Influenza A_Homo sapiens_hsa051640.52324747
122Adherens junction_Homo sapiens_hsa045200.52307227
123Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.51853841
124Oxytocin signaling pathway_Homo sapiens_hsa049210.51629493
125Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.50510738
126Viral carcinogenesis_Homo sapiens_hsa052030.49735597
127B cell receptor signaling pathway_Homo sapiens_hsa046620.49681814
128Estrogen signaling pathway_Homo sapiens_hsa049150.49030758
129Glioma_Homo sapiens_hsa052140.48692159
130Hepatitis B_Homo sapiens_hsa051610.48292909
131Pathways in cancer_Homo sapiens_hsa052000.47816289
132Hippo signaling pathway_Homo sapiens_hsa043900.47679561

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