DMWD

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)5.46053777
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.03280832
3locomotory exploration behavior (GO:0035641)5.02862849
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.89616247
5layer formation in cerebral cortex (GO:0021819)4.68786152
6positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.46150352
7vocalization behavior (GO:0071625)4.29812279
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.23759790
9synaptic vesicle exocytosis (GO:0016079)4.14571366
10glutamate secretion (GO:0014047)4.13314455
11synaptic vesicle docking involved in exocytosis (GO:0016081)4.06644972
12regulation of synaptic vesicle exocytosis (GO:2000300)4.03865106
13behavioral response to nicotine (GO:0035095)4.00086042
14regulation of synapse structural plasticity (GO:0051823)3.99394975
15regulation of glutamate receptor signaling pathway (GO:1900449)3.90013781
16dendritic spine morphogenesis (GO:0060997)3.88335710
17protein localization to synapse (GO:0035418)3.80652409
18regulation of neuronal synaptic plasticity (GO:0048168)3.73805160
19exploration behavior (GO:0035640)3.68299618
20regulation of long-term neuronal synaptic plasticity (GO:0048169)3.63683900
21cell migration in hindbrain (GO:0021535)3.58317599
22regulation of synaptic vesicle transport (GO:1902803)3.57582909
23neuron cell-cell adhesion (GO:0007158)3.52057866
24cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.49047233
25neuronal action potential propagation (GO:0019227)3.48024574
26cell communication by electrical coupling (GO:0010644)3.45379808
27positive regulation of synapse maturation (GO:0090129)3.39362720
28neurotransmitter secretion (GO:0007269)3.39354308
29negative regulation of synaptic transmission, GABAergic (GO:0032229)3.38737922
30regulation of dendritic spine morphogenesis (GO:0061001)3.33978656
31neuromuscular process controlling balance (GO:0050885)3.33565968
32ionotropic glutamate receptor signaling pathway (GO:0035235)3.24572467
33activation of protein kinase A activity (GO:0034199)3.21694954
34sodium ion export (GO:0071436)3.20772010
35synaptic transmission, glutamatergic (GO:0035249)3.16753547
36membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.16097323
37neuron recognition (GO:0008038)3.14103771
38cytoskeletal anchoring at plasma membrane (GO:0007016)3.13383203
39protein polyglutamylation (GO:0018095)3.09590931
40dendrite morphogenesis (GO:0048813)3.08622086
41proline transport (GO:0015824)3.08515864
42spinal cord development (GO:0021510)3.05946707
43establishment of nucleus localization (GO:0040023)3.05757843
44neurotransmitter-gated ion channel clustering (GO:0072578)3.05202912
45neuronal ion channel clustering (GO:0045161)3.05087338
46axonal fasciculation (GO:0007413)3.02873116
47gamma-aminobutyric acid transport (GO:0015812)3.01551723
48cerebellar Purkinje cell layer development (GO:0021680)2.99917009
49dermatan sulfate metabolic process (GO:0030205)2.99530719
50pharyngeal system development (GO:0060037)2.98033551
51plasma membrane repair (GO:0001778)2.95556079
52positive regulation of membrane potential (GO:0045838)2.92708027
53somite development (GO:0061053)2.92199102
54long-term memory (GO:0007616)2.91137252
55regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.87000164
56neuron-neuron synaptic transmission (GO:0007270)2.84323437
57ovulation cycle (GO:0042698)2.81788094
58kidney mesenchyme development (GO:0072074)2.80776159
59neuromuscular process controlling posture (GO:0050884)2.80758140
60regulation of excitatory postsynaptic membrane potential (GO:0060079)2.80618390
61positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.80471460
62regulation of synaptic plasticity (GO:0048167)2.80082075
63cellular potassium ion homeostasis (GO:0030007)2.80071844
64synaptic vesicle endocytosis (GO:0048488)2.79541809
65dendritic spine organization (GO:0097061)2.79116970
66outer ear morphogenesis (GO:0042473)2.78821531
67auditory behavior (GO:0031223)2.78561042
68cell proliferation in forebrain (GO:0021846)2.75800546
69negative regulation of potassium ion transmembrane transport (GO:1901380)2.75185396
70regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.74814447
71glutamate receptor signaling pathway (GO:0007215)2.74224706
72dermatan sulfate biosynthetic process (GO:0030208)2.73127279
73response to gravity (GO:0009629)2.73119114
74cranial nerve morphogenesis (GO:0021602)2.71727969
75regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.70605750
76innervation (GO:0060384)2.70396422
77lateral sprouting from an epithelium (GO:0060601)2.69714531
78axon ensheathment in central nervous system (GO:0032291)2.69538306
79central nervous system myelination (GO:0022010)2.69538306
80negative regulation of microtubule polymerization (GO:0031115)2.69443640
81positive regulation of dendritic spine development (GO:0060999)2.68624277
82positive regulation of synaptic transmission, GABAergic (GO:0032230)2.68095033
83cell communication involved in cardiac conduction (GO:0086065)2.67511484
84neuromuscular process (GO:0050905)2.67002973
85regulation of postsynaptic membrane potential (GO:0060078)2.66925645
86positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.66687262
87regulation of membrane repolarization (GO:0060306)2.66196750
88negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.65474267
89glycine transport (GO:0015816)2.65025367
90regulation of hippo signaling (GO:0035330)2.64931223
91regulation of mesoderm development (GO:2000380)2.64713485
92neurotransmitter transport (GO:0006836)2.64131434
93urinary tract smooth muscle contraction (GO:0014848)2.63930772
94postsynaptic membrane organization (GO:0001941)2.63849875
95regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.63720736
96regulation of dendritic spine development (GO:0060998)2.63443871
97organelle transport along microtubule (GO:0072384)2.62986252
98transmission of nerve impulse (GO:0019226)2.62460869
99regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.62129738
100vesicle transport along microtubule (GO:0047496)2.60584812
101establishment of mitochondrion localization (GO:0051654)2.60210780
102membrane depolarization during action potential (GO:0086010)2.60137478
103regulation of female receptivity (GO:0045924)2.60128410
104cerebellar granule cell differentiation (GO:0021707)2.57869084
105metanephric mesenchyme development (GO:0072075)2.57819600
106regulation of neurotransmitter secretion (GO:0046928)2.57710500
107positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.57385875
108synapse organization (GO:0050808)2.56479915
109G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.55271760
110presynaptic membrane assembly (GO:0097105)2.54984990
111establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.53636723
112mitochondrion transport along microtubule (GO:0047497)2.53636723
113prepulse inhibition (GO:0060134)2.53519537
114regulation of action potential (GO:0098900)2.53219201
115regulation of synapse maturation (GO:0090128)2.51900453
116regulation of respiratory system process (GO:0044065)2.51307576
117positive regulation of dendrite development (GO:1900006)2.50266021
118mating behavior (GO:0007617)2.49937202
119camera-type eye morphogenesis (GO:0048593)2.49407857
120nephron epithelium morphogenesis (GO:0072088)2.48746056
121nephron tubule morphogenesis (GO:0072078)2.48746056
122cerebellar Purkinje cell differentiation (GO:0021702)2.47674392
123regulation of neurotransmitter levels (GO:0001505)2.46236666
124regulation of vesicle fusion (GO:0031338)2.45033115
125positive regulation of fatty acid beta-oxidation (GO:0032000)2.43967458
126glycerophospholipid catabolic process (GO:0046475)2.43844407
127positive regulation of potassium ion transmembrane transport (GO:1901381)2.43325348
128lymphangiogenesis (GO:0001946)2.42784868
129membrane repolarization (GO:0086009)2.42386921
130negative regulation of astrocyte differentiation (GO:0048712)2.42243168
131negative regulation of catenin import into nucleus (GO:0035414)2.42112301
132neuromuscular synaptic transmission (GO:0007274)2.41756410
133primary amino compound metabolic process (GO:1901160)2.41460570
134appendage development (GO:0048736)2.40684353
135limb development (GO:0060173)2.40684353
136regulation of neurotransmitter transport (GO:0051588)2.40352375
137regulation of axon extension involved in axon guidance (GO:0048841)2.40264603
138positive regulation of protein kinase C signaling (GO:0090037)2.39686160
139central nervous system projection neuron axonogenesis (GO:0021952)2.39526877
140membrane depolarization (GO:0051899)2.37388111
141positive regulation of triglyceride biosynthetic process (GO:0010867)2.36536695
142protein heterotrimerization (GO:0070208)2.35619863
143cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.35112865
144presynaptic membrane organization (GO:0097090)2.34856308
145cornea development in camera-type eye (GO:0061303)2.33372463
146serotonin metabolic process (GO:0042428)2.32235266
147lung epithelium development (GO:0060428)2.32208786
148positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.31060962
149positive regulation of action potential (GO:0045760)2.28683505
150lung-associated mesenchyme development (GO:0060484)2.28347242
151calcium ion-dependent exocytosis (GO:0017156)2.27390179
152positive regulation of fatty acid oxidation (GO:0046321)2.26892019
153lung morphogenesis (GO:0060425)2.24297947
154negative regulation of axon extension involved in axon guidance (GO:0048843)2.23453215
155regulation of rhodopsin mediated signaling pathway (GO:0022400)2.23322612
156regulation of axon guidance (GO:1902667)2.22955107
157pattern specification involved in kidney development (GO:0061004)2.21200695
158phosphatidylethanolamine biosynthetic process (GO:0006646)2.20509724
159outflow tract septum morphogenesis (GO:0003148)2.19423913
160G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.18047503
161ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.16867144
162cochlea morphogenesis (GO:0090103)2.16835672
163thyroid gland development (GO:0030878)2.16692079

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.99528114
2RARB_27405468_Chip-Seq_BRAIN_Mouse2.81740050
3EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.81658592
4EZH2_18974828_ChIP-Seq_MESCs_Mouse2.61540260
5RNF2_18974828_ChIP-Seq_MESCs_Mouse2.61540260
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.60459844
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.59185841
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.57377961
9EZH2_27304074_Chip-Seq_ESCs_Mouse2.40873444
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.40214283
11DROSHA_22980978_ChIP-Seq_HELA_Human2.40051927
12ZFP281_18757296_ChIP-ChIP_E14_Mouse2.31984584
13TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.31511909
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.28970625
15REST_21632747_ChIP-Seq_MESCs_Mouse2.28521162
16NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.22090228
17SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.21400507
18MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.18333057
19* EZH2_27294783_Chip-Seq_ESCs_Mouse2.17044594
20SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.14592216
21SUZ12_27294783_Chip-Seq_ESCs_Mouse2.10855816
22RNF2_27304074_Chip-Seq_ESCs_Mouse2.10852673
23ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.10023831
24CBX2_27304074_Chip-Seq_ESCs_Mouse2.08638176
25ERG_21242973_ChIP-ChIP_JURKAT_Human2.07006377
26REST_18959480_ChIP-ChIP_MESCs_Mouse2.06296429
27SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.05644972
28SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.04413179
29WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.92947361
30CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.92903306
31EED_16625203_ChIP-ChIP_MESCs_Mouse1.92176620
32KDM2B_26808549_Chip-Seq_K562_Human1.89230012
33SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.81536589
34GBX2_23144817_ChIP-Seq_PC3_Human1.78420148
35ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.71078816
36ZFP281_27345836_Chip-Seq_ESCs_Mouse1.62741732
37* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.62085235
38DNAJC2_21179169_ChIP-ChIP_NT2_Human1.57903959
39RING1B_27294783_Chip-Seq_ESCs_Mouse1.55288774
40ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.54552459
41P68_20966046_ChIP-Seq_HELA_Human1.53497924
42TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.53142627
43BMI1_23680149_ChIP-Seq_NPCS_Mouse1.52133417
44EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.51253214
45STAT6_21828071_ChIP-Seq_BEAS2B_Human1.48963640
46RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.48735765
47TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.45025043
48RING1B_27294783_Chip-Seq_NPCs_Mouse1.43957624
49IKZF1_21737484_ChIP-ChIP_HCT116_Human1.41199443
50* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.39966906
51* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.36342023
52CTCF_27219007_Chip-Seq_Bcells_Human1.35475976
53DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.34181885
54RNF2_27304074_Chip-Seq_NSC_Mouse1.29579910
55TP53_22127205_ChIP-Seq_IMR90_Human1.29095980
56SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.27771055
57CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.26547987
58OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.25641899
59PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.24824082
60RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.22335820
61TET1_21490601_ChIP-Seq_MESCs_Mouse1.21557645
62KDM2B_26808549_Chip-Seq_DND41_Human1.21212436
63AR_21572438_ChIP-Seq_LNCaP_Human1.20200469
64CTCF_20526341_ChIP-Seq_ESCs_Human1.19494706
65* LXR_22292898_ChIP-Seq_THP-1_Human1.18930774
66ZNF263_19887448_ChIP-Seq_K562_Human1.18296982
67ZNF274_21170338_ChIP-Seq_K562_Hela1.17985080
68TP53_20018659_ChIP-ChIP_R1E_Mouse1.15808220
69TET1_21451524_ChIP-Seq_MESCs_Mouse1.14490332
70ERA_21632823_ChIP-Seq_H3396_Human1.12512699
71AR_19668381_ChIP-Seq_PC3_Human1.11276451
72EP300_21415370_ChIP-Seq_HL-1_Mouse1.10266232
73VDR_22108803_ChIP-Seq_LS180_Human1.09058264
74GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08902263
75* KDM2B_26808549_Chip-Seq_JURKAT_Human1.07043081
76CREB1_26743006_Chip-Seq_LNCaP_Human1.04629465
77GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.03492228
78TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.03222852
79SMC4_20622854_ChIP-Seq_HELA_Human1.03017163
80SOX2_21211035_ChIP-Seq_LN229_Gbm1.02139660
81RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.02018547
82BCL6_27268052_Chip-Seq_Bcells_Human1.01468566
83PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.00021374
84KLF4_19829295_ChIP-Seq_ESCs_Human0.98950445
85TP63_22573176_ChIP-Seq_HFKS_Human0.97898010
86* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.97556379
87E2F1_20622854_ChIP-Seq_HELA_Human0.97490587
88NR3C1_23031785_ChIP-Seq_PC12_Mouse0.97469883
89ESR2_21235772_ChIP-Seq_MCF-7_Human0.97187746
90SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.97025968
91TDRD3_21172665_ChIP-Seq_MCF-7_Human0.96686753
92RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.96257503
93* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.95912971
94CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.95595517
95SMC3_22415368_ChIP-Seq_MEFs_Mouse0.94915899
96RAD21_21589869_ChIP-Seq_MESCs_Mouse0.94842698
97* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.94583921
98EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.94395960
99CTBP2_25329375_ChIP-Seq_LNCAP_Human0.94295737
100TP63_19390658_ChIP-ChIP_HaCaT_Human0.93867007
101ISL1_27105846_Chip-Seq_CPCs_Mouse0.93462815
102SA1_27219007_Chip-Seq_ERYTHROID_Human0.93213231
103MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.92309197
104SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.91919107
105ELF1_20517297_ChIP-Seq_JURKAT_Human0.91333491
106SMAD4_21741376_ChIP-Seq_HESCs_Human0.90819843
107OCT4_19829295_ChIP-Seq_ESCs_Human0.90469698
108P300_27058665_Chip-Seq_ZR-75-30cells_Human0.90186373
109* MYC_27129775_Chip-Seq_CORNEA_Mouse0.89989842
110PHF8_20622854_ChIP-Seq_HELA_Human0.89500434
111YAP1_20516196_ChIP-Seq_MESCs_Mouse0.88566264
112* TP53_23651856_ChIP-Seq_MEFs_Mouse0.88070154
113GATA1_26923725_Chip-Seq_HPCs_Mouse0.86221614
114SMAD3_21741376_ChIP-Seq_ESCs_Human0.84888638
115* SA1_27219007_Chip-Seq_Bcells_Human0.84459156
116RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.84075565
117MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.83971698
118SMAD3_21741376_ChIP-Seq_HESCs_Human0.83824209
119CTBP1_25329375_ChIP-Seq_LNCAP_Human0.83202808
120UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.82673021
121ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.81500106
122ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.80533470
123SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.80480476
124GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.80231044
125OCT4_20526341_ChIP-Seq_ESCs_Human0.79702149
126PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.79494772
127P53_22127205_ChIP-Seq_FIBROBLAST_Human0.79034533
128NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.78118924
129SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.77617897
130SMAD4_21799915_ChIP-Seq_A2780_Human0.77418788
131THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.76160204
132AHR_22903824_ChIP-Seq_MCF-7_Human0.75708559

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.64393675
2MP0004270_analgesia3.37273579
3MP0003635_abnormal_synaptic_transmissio3.25507016
4MP0003880_abnormal_central_pattern3.17751620
5MP0002249_abnormal_larynx_morphology2.66218258
6MP0000751_myopathy2.59228399
7MP0002063_abnormal_learning/memory/cond2.54873841
8MP0009745_abnormal_behavioral_response2.35081230
9MP0002064_seizures2.31241063
10MP0000049_abnormal_middle_ear2.16175983
11MP0002822_catalepsy2.09035520
12MP0002734_abnormal_mechanical_nocicepti2.05102510
13MP0009046_muscle_twitch2.03701621
14MP0004858_abnormal_nervous_system2.03424147
15MP0005503_abnormal_tendon_morphology2.03209067
16MP0005423_abnormal_somatic_nervous2.00382859
17MP0002572_abnormal_emotion/affect_behav1.94169468
18MP0005670_abnormal_white_adipose1.93980548
19MP0000778_abnormal_nervous_system1.90614428
20MP0001968_abnormal_touch/_nociception1.90204309
21MP0002653_abnormal_ependyma_morphology1.89820176
22MP0002272_abnormal_nervous_system1.88107262
23MP0005623_abnormal_meninges_morphology1.86115305
24MP0009780_abnormal_chondrocyte_physiolo1.85296341
25MP0003283_abnormal_digestive_organ1.82573154
26MP0004885_abnormal_endolymph1.80519039
27MP0003329_amyloid_beta_deposits1.77524626
28MP0006292_abnormal_olfactory_placode1.76886198
29MP0002837_dystrophic_cardiac_calcinosis1.75655192
30MP0001486_abnormal_startle_reflex1.74589774
31MP0009384_cardiac_valve_regurgitation1.69652049
32MP0004145_abnormal_muscle_electrophysio1.66090946
33MP0000955_abnormal_spinal_cord1.65495871
34MP0004811_abnormal_neuron_physiology1.61955226
35MP0003122_maternal_imprinting1.61493664
36MP0002909_abnormal_adrenal_gland1.60681290
37MP0001440_abnormal_grooming_behavior1.51972708
38MP0002733_abnormal_thermal_nociception1.51817563
39MP0002184_abnormal_innervation1.51704189
40MP0000678_abnormal_parathyroid_gland1.50126878
41MP0004233_abnormal_muscle_weight1.48511914
42MP0001348_abnormal_lacrimal_gland1.47953524
43MP0000026_abnormal_inner_ear1.47854220
44MP0010030_abnormal_orbit_morphology1.46184828
45MP0008569_lethality_at_weaning1.42747918
46MP0001970_abnormal_pain_threshold1.39376620
47MP0002102_abnormal_ear_morphology1.37684106
48MP0003938_abnormal_ear_development1.34990036
49MP0002882_abnormal_neuron_morphology1.34955357
50MP0003646_muscle_fatigue1.34569886
51MP0009250_abnormal_appendicular_skeleto1.33458101
52MP0003137_abnormal_impulse_conducting1.32586297
53MP0004084_abnormal_cardiac_muscle1.32257587
54MP0002067_abnormal_sensory_capabilities1.30363352
55MP0000631_abnormal_neuroendocrine_gland1.28860814
56MP0002735_abnormal_chemical_nociception1.26330134
57MP0001188_hyperpigmentation1.26191873
58MP0002736_abnormal_nociception_after1.25916681
59MP0000566_synostosis1.25821988
60MP0009053_abnormal_anal_canal1.25675117
61MP0000747_muscle_weakness1.24802281
62MP0004215_abnormal_myocardial_fiber1.24564062
63MP0002066_abnormal_motor_capabilities/c1.23811746
64MP0002932_abnormal_joint_morphology1.23800557
65MP0005551_abnormal_eye_electrophysiolog1.23292949
66MP0002557_abnormal_social/conspecific_i1.22786179
67MP0005386_behavior/neurological_phenoty1.22650651
68MP0004924_abnormal_behavior1.22650651
69MP0002152_abnormal_brain_morphology1.22064579
70MP0008775_abnormal_heart_ventricle1.20605848
71MP0002876_abnormal_thyroid_physiology1.18303159
72MP0000534_abnormal_ureter_morphology1.15390796
73MP0004036_abnormal_muscle_relaxation1.14414879
74MP0001963_abnormal_hearing_physiology1.12862093
75MP0004085_abnormal_heartbeat1.11909967
76MP0001501_abnormal_sleep_pattern1.09637026
77MP0004087_abnormal_muscle_fiber1.07800571
78MP0003634_abnormal_glial_cell1.06945101
79MP0008961_abnormal_basal_metabolism1.05346444
80MP0003279_aneurysm1.05108490
81MP0001299_abnormal_eye_distance/1.02955578
82MP0003119_abnormal_digestive_system1.02945703
83MP0002234_abnormal_pharynx_morphology1.01570572
84MP0003861_abnormal_nervous_system1.01040747
85MP0003705_abnormal_hypodermis_morpholog0.98963399
86MP0002116_abnormal_craniofacial_bone0.98621519
87MP0003879_abnormal_hair_cell0.98606781
88MP0000749_muscle_degeneration0.97856335
89MP0001529_abnormal_vocalization0.97780477
90MP0001958_emphysema0.97293645
91MP0000681_abnormal_thyroid_gland0.96761881
92MP0002269_muscular_atrophy0.96558926
93MP0003937_abnormal_limbs/digits/tail_de0.96378569
94MP0001485_abnormal_pinna_reflex0.96226358
95MP0002638_abnormal_pupillary_reflex0.94879043
96MP0000013_abnormal_adipose_tissue0.91913413
97MP0000759_abnormal_skeletal_muscle0.91477307
98MP0000537_abnormal_urethra_morphology0.90824967
99MP0005171_absent_coat_pigmentation0.89737463
100MP0010368_abnormal_lymphatic_system0.89447247
101MP0004142_abnormal_muscle_tone0.89085643
102MP0005330_cardiomyopathy0.89022074
103MP0003633_abnormal_nervous_system0.88842882
104MP0005620_abnormal_muscle_contractility0.88657049
105MP0002108_abnormal_muscle_morphology0.88046527
106MP0008789_abnormal_olfactory_epithelium0.87982201
107MP0000920_abnormal_myelination0.87835967
108MP0003631_nervous_system_phenotype0.87285903
109MP0001270_distended_abdomen0.86574195
110MP0009379_abnormal_foot_pigmentation0.86264640
111MP0002282_abnormal_trachea_morphology0.86154214
112MP0005187_abnormal_penis_morphology0.85997784
113MP0003123_paternal_imprinting0.84808443
114MP0000467_abnormal_esophagus_morphology0.84300309
115MP0003632_abnormal_nervous_system0.84299032
116MP0002106_abnormal_muscle_physiology0.83937969
117MP0004133_heterotaxia0.83381959
118MP0003787_abnormal_imprinting0.83380432
119MP0004742_abnormal_vestibular_system0.82621770
120MP0002160_abnormal_reproductive_system0.82538270
121MP0003755_abnormal_palate_morphology0.81755998
122MP0003136_yellow_coat_color0.81259185
123MP0005167_abnormal_blood-brain_barrier0.81057728
124MP0003385_abnormal_body_wall0.80895138
125MP0004130_abnormal_muscle_cell0.80489703
126MP0005508_abnormal_skeleton_morphology0.80073541
127MP0000428_abnormal_craniofacial_morphol0.78766713
128MP0001984_abnormal_olfaction0.78582055
129MP0005369_muscle_phenotype0.78284772
130MP0002229_neurodegeneration0.77470964
131MP0002752_abnormal_somatic_nervous0.76818193
132MP0006138_congestive_heart_failure0.76760717
133MP0006276_abnormal_autonomic_nervous0.75644814
134MP0000003_abnormal_adipose_tissue0.72755939
135MP0002972_abnormal_cardiac_muscle0.72515616
136MP0005646_abnormal_pituitary_gland0.72469298
137MP0001177_atelectasis0.71817884
138MP0001502_abnormal_circadian_rhythm0.71457110
139MP0004484_altered_response_of0.71071123
140MP0001905_abnormal_dopamine_level0.68607209
141MP0004272_abnormal_basement_membrane0.68559927
142MP0005394_taste/olfaction_phenotype0.68458436
143MP0005499_abnormal_olfactory_system0.68458436
144MP0003942_abnormal_urinary_system0.67925783

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)5.40309905
2Morphological abnormality of the middle ear (HP:0008609)4.21135451
3Focal motor seizures (HP:0011153)3.87845237
4Focal seizures (HP:0007359)3.56942519
5Abnormality of the lower motor neuron (HP:0002366)3.27498811
6Visual hallucinations (HP:0002367)3.21395061
7Ankle clonus (HP:0011448)3.14122551
8Abnormality of the aortic arch (HP:0012303)2.99543229
9Congenital stationary night blindness (HP:0007642)2.90369909
10Supranuclear gaze palsy (HP:0000605)2.87941919
11Action tremor (HP:0002345)2.86650999
12Insomnia (HP:0100785)2.81359475
13Sudden death (HP:0001699)2.67288664
14Atonic seizures (HP:0010819)2.59376163
15Ventricular fibrillation (HP:0001663)2.58648474
16Depression (HP:0000716)2.52588889
17Nephronophthisis (HP:0000090)2.51820812
18Progressive cerebellar ataxia (HP:0002073)2.51491392
19Bundle branch block (HP:0011710)2.50940296
20Short 4th metacarpal (HP:0010044)2.50170507
21Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.50170507
22Epileptic encephalopathy (HP:0200134)2.50132083
23Termporal pattern (HP:0011008)2.48037256
24Insidious onset (HP:0003587)2.48037256
25Impaired vibration sensation in the lower limbs (HP:0002166)2.46983431
26Urinary urgency (HP:0000012)2.42508808
27Cerebral inclusion bodies (HP:0100314)2.41819409
28Urinary bladder sphincter dysfunction (HP:0002839)2.37532479
29Postural instability (HP:0002172)2.33929364
30Abnormality of the middle phalanges of the toes (HP:0010183)2.32567818
31Megalencephaly (HP:0001355)2.28837422
32Molar tooth sign on MRI (HP:0002419)2.28510447
33Abnormality of midbrain morphology (HP:0002418)2.28510447
34Poor eye contact (HP:0000817)2.27883308
35Bilateral microphthalmos (HP:0007633)2.27821660
36Difficulty running (HP:0009046)2.27727821
37Lymphangioma (HP:0100764)2.26919260
38Pointed chin (HP:0000307)2.25036702
39Amblyopia (HP:0000646)2.24469379
40Type II lissencephaly (HP:0007260)2.24274518
41Increased corneal curvature (HP:0100692)2.23188484
42Keratoconus (HP:0000563)2.23188484
43Abnormality of the 4th metacarpal (HP:0010012)2.22899961
44Generalized tonic-clonic seizures (HP:0002069)2.21230926
45Morphological abnormality of the inner ear (HP:0011390)2.21177623
46Exercise-induced myalgia (HP:0003738)2.18925989
47Absence seizures (HP:0002121)2.18653074
48Neurofibrillary tangles (HP:0002185)2.18601866
49Abnormal social behavior (HP:0012433)2.18255542
50Impaired social interactions (HP:0000735)2.18255542
51Abnormal number of incisors (HP:0011064)2.18174243
52Torticollis (HP:0000473)2.18105703
53Spastic gait (HP:0002064)2.17292076
54Cutaneous finger syndactyly (HP:0010554)2.16757132
55Dysdiadochokinesis (HP:0002075)2.15217658
56Dysmetria (HP:0001310)2.13967956
57Abnormality of cochlea (HP:0000375)2.13798150
58Aplasia/Hypoplasia of the patella (HP:0006498)2.13667072
59Abnormality of the corticospinal tract (HP:0002492)2.12599763
60Myotonia (HP:0002486)2.12548409
61Hyperthyroidism (HP:0000836)2.11812758
62Hyperacusis (HP:0010780)2.11540983
63Cystic liver disease (HP:0006706)2.11213341
64Bronchomalacia (HP:0002780)2.10852438
65Synostosis of carpal bones (HP:0005048)2.10614817
66Lower limb amyotrophy (HP:0007210)2.09487758
67Shallow orbits (HP:0000586)2.08277011
68Broad hallux (HP:0010055)2.08202525
69Mesangial abnormality (HP:0001966)2.08075471
70Genetic anticipation (HP:0003743)2.07289258
71Rib fusion (HP:0000902)2.07230157
72Upper limb amyotrophy (HP:0009129)2.06772091
73Distal upper limb amyotrophy (HP:0007149)2.06772091
74Abnormality of the nasal septum (HP:0000419)2.06540788
75Short hallux (HP:0010109)2.04490240
76Overriding aorta (HP:0002623)2.01340508
77Tubular atrophy (HP:0000092)2.01293750
78Muscle fiber splitting (HP:0003555)2.00432421
79Increased variability in muscle fiber diameter (HP:0003557)1.99837964
80Broad-based gait (HP:0002136)1.99721771
81Shawl scrotum (HP:0000049)1.99649657
82Rapidly progressive (HP:0003678)1.99570455
83Dialeptic seizures (HP:0011146)1.99470552
84Abnormality of the renal medulla (HP:0100957)1.99412451
85Neoplasm of the heart (HP:0100544)1.99283107
86Lower limb muscle weakness (HP:0007340)1.97128180
87Anxiety (HP:0000739)1.96361925
88Achilles tendon contracture (HP:0001771)1.96120205
89Annular pancreas (HP:0001734)1.95527498
90Difficulty climbing stairs (HP:0003551)1.95301903
91Aplasia of the phalanges of the hand (HP:0009802)1.94555956
92Aplasia involving bones of the extremities (HP:0009825)1.94555956
93Aplasia involving bones of the upper limbs (HP:0009823)1.94555956
94Pancreatic cysts (HP:0001737)1.94195423
95Prolonged QT interval (HP:0001657)1.93890975
96Short femoral neck (HP:0100864)1.93798691
97Patellar aplasia (HP:0006443)1.93652714
98Pheochromocytoma (HP:0002666)1.93118365
99Obstructive sleep apnea (HP:0002870)1.92660774
100Abnormality of the proximal phalanges of the hand (HP:0009834)1.92604942
101Renal dysplasia (HP:0000110)1.92062207
102Tented upper lip vermilion (HP:0010804)1.91968699
103Hyporeflexia of lower limbs (HP:0002600)1.91760354
104Coronal craniosynostosis (HP:0004440)1.91575631
105Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.91084077
106Renal duplication (HP:0000075)1.90809585
107Stridor (HP:0010307)1.89324309
108Bulbous nose (HP:0000414)1.89293983
109Focal dystonia (HP:0004373)1.88934974
110Hemiplegia (HP:0002301)1.88924875
111Elfin facies (HP:0004428)1.88596419
112Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.88306802
113Short 1st metacarpal (HP:0010034)1.88306802
114True hermaphroditism (HP:0010459)1.87501480
115Dysmetric saccades (HP:0000641)1.87257225
116Severe muscular hypotonia (HP:0006829)1.87110582
117Cutaneous syndactyly (HP:0012725)1.86831880
118Attenuation of retinal blood vessels (HP:0007843)1.86598386
119Hypoplastic ischia (HP:0003175)1.86251351
120Hemiparesis (HP:0001269)1.86218578
121Cutaneous melanoma (HP:0012056)1.85757000
122Pendular nystagmus (HP:0012043)1.85538611
123Neoplasm of the peripheral nervous system (HP:0100007)1.85340859
124Abnormality of the calf musculature (HP:0001430)1.85171997
125Clumsiness (HP:0002312)1.84677977
126Aplasia/Hypoplasia of the hallux (HP:0008362)1.83013977
127Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.82614516
128Cerebellar dysplasia (HP:0007033)1.81372022
129Aplasia/Hypoplasia of the spleen (HP:0010451)1.80878449
130Abnormality of the incisor (HP:0000676)1.79755482
131Broad toe (HP:0001837)1.78367466
132Aplasia/Hypoplasia of the sternum (HP:0006714)1.78260222
133Fetal akinesia sequence (HP:0001989)1.77794626
134Mutism (HP:0002300)1.75557232
135Vitreoretinal degeneration (HP:0000655)1.75147083
136Bowing of the arm (HP:0006488)1.74822962
137Bowed forearm bones (HP:0003956)1.74822962
138Abnormal EKG (HP:0003115)1.73973971
139Chorioretinal atrophy (HP:0000533)1.73971573
140Intention tremor (HP:0002080)1.73792020
141Buphthalmos (HP:0000557)1.73727826
142Abnormality of the Achilles tendon (HP:0005109)1.73628386
143Sleep apnea (HP:0010535)1.73446848
144EMG: myopathic abnormalities (HP:0003458)1.73392723
145Craniofacial dystonia (HP:0012179)1.73326547
146Turricephaly (HP:0000262)1.73044703
147Hypoplasia of the ulna (HP:0003022)1.72938398
148Primary atrial arrhythmia (HP:0001692)1.72542822
149Impaired smooth pursuit (HP:0007772)1.71720387
150Amyotrophic lateral sclerosis (HP:0007354)1.70206111
151Hypoventilation (HP:0002791)1.69913266
152Neonatal short-limb short stature (HP:0008921)1.69479421
153Astrocytoma (HP:0009592)1.68771540
154Abnormality of the astrocytes (HP:0100707)1.68771540
155Resting tremor (HP:0002322)1.68710638
156Clonus (HP:0002169)1.68141740
157Aplasia/Hypoplasia involving the pelvis (HP:0009103)1.67801966
158Atrial fibrillation (HP:0005110)1.67620372
159Flat cornea (HP:0007720)1.66616768
160Truncus arteriosus (HP:0001660)1.66556289
161Abnormal eating behavior (HP:0100738)1.65705726
162Shoulder girdle muscle weakness (HP:0003547)1.65696679
163Truncal ataxia (HP:0002078)1.65521227
164Limited hip movement (HP:0008800)1.65438082
165Pancreatic fibrosis (HP:0100732)1.65388067
166Broad metatarsal (HP:0001783)1.65381588
167Hammertoe (HP:0001765)1.65263899
168Bladder diverticulum (HP:0000015)1.64827005
169Abnormality of binocular vision (HP:0011514)1.64555251
170Diplopia (HP:0000651)1.64555251
171Bradykinesia (HP:0002067)1.64166630
172Supraventricular arrhythmia (HP:0005115)1.63495801
173Febrile seizures (HP:0002373)1.63201565
174Limb dystonia (HP:0002451)1.63122036
175Muscle hypertrophy of the lower extremities (HP:0008968)1.62877962
176Calf muscle hypertrophy (HP:0008981)1.62684962
177Infantile muscular hypotonia (HP:0008947)1.62108989
178Ventricular arrhythmia (HP:0004308)1.61930443
179Supraventricular tachycardia (HP:0004755)1.61823454
180Hip contracture (HP:0003273)1.61561626
181Abnormality of the 1st metacarpal (HP:0010009)1.60201067
182Abnormality of the renal collecting system (HP:0004742)1.59990366
183Polydipsia (HP:0001959)1.59374354
184Abnormal drinking behavior (HP:0030082)1.59374354

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRKD33.50978316
2MAP3K93.36030560
3EPHA43.34560294
4FRK3.26457170
5NTRK32.99622612
6MARK12.96065791
7PAK62.57631075
8LATS22.30512764
9MAP3K42.20145825
10TRIB32.13914611
11MINK12.12991681
12KSR22.12916159
13DAPK22.12148557
14SIK12.12136295
15MAPK152.11277927
16GRK12.03657134
17NTRK12.03606066
18ICK1.99036082
19TYRO31.97478881
20ADRBK21.86066941
21MUSK1.81664061
22PHKG21.67928188
23PHKG11.67928188
24NTRK21.63623970
25TLK11.60684851
26CAMKK11.50709080
27UHMK11.44029660
28MAP2K41.43903485
29TAOK11.38794612
30STK381.37512742
31PNCK1.36877702
32KSR11.36730673
33PKN21.31797833
34NEK11.31617096
35CDK51.25944579
36INSRR1.22748784
37CASK1.19880152
38BMPR1B1.18919034
39PDGFRA1.17916848
40ALK1.16214144
41MAP2K71.13681624
42LMTK21.13241855
43CAMK1D1.13238611
44RPS6KA61.13108216
45TIE11.12115376
46PRPF4B1.09806552
47PKN11.08343007
48MAPKAPK31.07799741
49RET1.07773911
50PAK31.07314537
51ADRBK11.04756194
52RIPK11.04479894
53CDK141.02971166
54CDK151.01385495
55CDK180.97380458
56PRKCH0.96863992
57RPS6KL10.93199861
58RPS6KC10.93199861
59PINK10.93148459
60DYRK20.90303685
61CDK190.89798567
62CDK11A0.89531271
63DAPK10.89105841
64DDR20.87848929
65GRK50.87827279
66STK110.87718798
67MAPK130.87681323
68LIMK10.87542147
69DMPK0.86525865
70BCKDK0.85274943
71ARAF0.84845810
72MARK20.84410663
73EEF2K0.83908369
74MAP3K20.83872934
75MAP2K20.83648602
76SGK20.83540364
77TTN0.83235411
78PRKCG0.81403071
79EPHB20.81331099
80TNIK0.80792063
81CDK80.79045597
82PTK2B0.77026048
83PLK20.76785929
84HIPK20.76506377
85CSNK1G20.73627070
86ERBB20.73337759
87SIK20.72511326
88MYLK0.70891260
89CDC42BPA0.69322641
90SGK30.69309862
91PRKAA10.69190559
92SGK2230.68260237
93SGK4940.68260237
94CAMK2A0.67190349
95ROCK20.66916637
96BMX0.64832551
97AKT30.64704458
98PRKCI0.63684757
99PRKG20.63326734
100MTOR0.63187593
101CAMK10.62618058
102STK390.61794841
103DAPK30.61332603
104PDK30.60398650
105PDK40.60398650
106WNK10.60305709
107CHUK0.59695751
108MAP2K60.58912595
109MAPK120.58212580
110WNK40.57967760
111ROCK10.57909405
112CAMK2B0.55199082
113FGFR20.54839244
114BRSK10.54150092
115SCYL20.54100472
116MAP3K70.53812691
117OXSR10.53223636
118PDPK10.52746980
119MAPKAPK50.52577745
120CAMK2D0.51752004
121CAMK2G0.51302704
122PRKD10.51256923
123MAPK100.50273348
124MAP4K20.49413091
125PRKD20.49404180
126FER0.49384326
127PRKCZ0.49275022
128RPS6KA30.49124228
129PRKCE0.48917584
130PTK20.47725191
131MAP3K60.46574002
132MAPK80.46570369
133RPS6KA20.46107067
134CAMK1G0.45485567
135MAP2K10.44571340
136STK38L0.44215295
137MOS0.43855935
138MAP3K10.43238865
139ILK0.43063138
140SGK10.42675746
141DYRK1A0.41287041
142CAMK40.40880108
143PAK20.40384944
144CDK30.39143319

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047212.69256109
2Sulfur relay system_Homo sapiens_hsa041222.42316927
3Nicotine addiction_Homo sapiens_hsa050332.35001421
4Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.30907249
5Olfactory transduction_Homo sapiens_hsa047402.28549400
6GABAergic synapse_Homo sapiens_hsa047272.23065051
7Circadian entrainment_Homo sapiens_hsa047132.21580557
8Long-term potentiation_Homo sapiens_hsa047202.17785087
9Glutamatergic synapse_Homo sapiens_hsa047242.07945928
10Amphetamine addiction_Homo sapiens_hsa050311.99682120
11Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.94926858
12Dopaminergic synapse_Homo sapiens_hsa047281.91756260
13Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.91524125
14Morphine addiction_Homo sapiens_hsa050321.88215354
15Nitrogen metabolism_Homo sapiens_hsa009101.85175551
16Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.78682363
17Insulin secretion_Homo sapiens_hsa049111.74238570
18Cholinergic synapse_Homo sapiens_hsa047251.70085200
19Aldosterone synthesis and secretion_Homo sapiens_hsa049251.64074620
20Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.63783254
21Salivary secretion_Homo sapiens_hsa049701.63335155
22Gastric acid secretion_Homo sapiens_hsa049711.61399170
23Oxytocin signaling pathway_Homo sapiens_hsa049211.55797300
24Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.53494919
25Gap junction_Homo sapiens_hsa045401.53338413
26Axon guidance_Homo sapiens_hsa043601.52022520
27Cocaine addiction_Homo sapiens_hsa050301.51128657
28Dilated cardiomyopathy_Homo sapiens_hsa054141.48281190
29Cardiac muscle contraction_Homo sapiens_hsa042601.46264904
30GnRH signaling pathway_Homo sapiens_hsa049121.43310516
31alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.42161274
32Glioma_Homo sapiens_hsa052141.39796053
33Linoleic acid metabolism_Homo sapiens_hsa005911.35475299
34Renin secretion_Homo sapiens_hsa049241.34873653
35Long-term depression_Homo sapiens_hsa047301.34342424
36Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.32942524
37Notch signaling pathway_Homo sapiens_hsa043301.32718453
38ECM-receptor interaction_Homo sapiens_hsa045121.31153274
39Estrogen signaling pathway_Homo sapiens_hsa049151.30703782
40Taste transduction_Homo sapiens_hsa047421.28169782
41Melanogenesis_Homo sapiens_hsa049161.27325805
42Calcium signaling pathway_Homo sapiens_hsa040201.23081948
43Oocyte meiosis_Homo sapiens_hsa041141.21979464
44Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.20017392
45ErbB signaling pathway_Homo sapiens_hsa040121.16100273
46Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.14199662
47cAMP signaling pathway_Homo sapiens_hsa040241.10497937
48Serotonergic synapse_Homo sapiens_hsa047261.10406505
49Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.09791905
50Dorso-ventral axis formation_Homo sapiens_hsa043201.09671213
51cGMP-PKG signaling pathway_Homo sapiens_hsa040221.07748237
52Type II diabetes mellitus_Homo sapiens_hsa049301.07183180
53Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.05441976
54Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.98800208
55Phospholipase D signaling pathway_Homo sapiens_hsa040720.98781082
56Hedgehog signaling pathway_Homo sapiens_hsa043400.97262150
57mTOR signaling pathway_Homo sapiens_hsa041500.95072424
58Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.92303861
59Tight junction_Homo sapiens_hsa045300.91929397
60Glycerolipid metabolism_Homo sapiens_hsa005610.91757954
61Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.91708375
62Hippo signaling pathway_Homo sapiens_hsa043900.91521727
63Vascular smooth muscle contraction_Homo sapiens_hsa042700.91042913
64Renal cell carcinoma_Homo sapiens_hsa052110.90269517
65VEGF signaling pathway_Homo sapiens_hsa043700.89718096
66Thyroid hormone signaling pathway_Homo sapiens_hsa049190.88226923
67Protein digestion and absorption_Homo sapiens_hsa049740.87625194
68Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.86704583
69Maturity onset diabetes of the young_Homo sapiens_hsa049500.85172273
702-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.83216483
71Glycerophospholipid metabolism_Homo sapiens_hsa005640.82587348
72Melanoma_Homo sapiens_hsa052180.82027061
73Wnt signaling pathway_Homo sapiens_hsa043100.81876207
74Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.81663889
75ABC transporters_Homo sapiens_hsa020100.81301968
76Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.80949843
77Endometrial cancer_Homo sapiens_hsa052130.80818021
78Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.80738144
79Ether lipid metabolism_Homo sapiens_hsa005650.79479337
80Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.79422606
81Glucagon signaling pathway_Homo sapiens_hsa049220.79150122
82Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.78295048
83MAPK signaling pathway_Homo sapiens_hsa040100.77364702
84Phosphatidylinositol signaling system_Homo sapiens_hsa040700.77314619
85Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.77098672
86Neurotrophin signaling pathway_Homo sapiens_hsa047220.76655638
87Insulin signaling pathway_Homo sapiens_hsa049100.75632328
88Longevity regulating pathway - mammal_Homo sapiens_hsa042110.74553513
89Basal cell carcinoma_Homo sapiens_hsa052170.74233830
90Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.73013779
91Fatty acid biosynthesis_Homo sapiens_hsa000610.72905737
92Rap1 signaling pathway_Homo sapiens_hsa040150.71173181
93Choline metabolism in cancer_Homo sapiens_hsa052310.69483086
94Endocytosis_Homo sapiens_hsa041440.68262128
95Central carbon metabolism in cancer_Homo sapiens_hsa052300.66576121
96Non-small cell lung cancer_Homo sapiens_hsa052230.65163760
97Ras signaling pathway_Homo sapiens_hsa040140.64549713
98Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.64120775
99Focal adhesion_Homo sapiens_hsa045100.62937308
100Thyroid hormone synthesis_Homo sapiens_hsa049180.62007697
101Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.60604106
102Bladder cancer_Homo sapiens_hsa052190.60441344
103Prion diseases_Homo sapiens_hsa050200.60062857
104Bile secretion_Homo sapiens_hsa049760.58130931
105AMPK signaling pathway_Homo sapiens_hsa041520.55223716
106Proteoglycans in cancer_Homo sapiens_hsa052050.53275269
107RNA polymerase_Homo sapiens_hsa030200.53014254
108Collecting duct acid secretion_Homo sapiens_hsa049660.52168224
109TGF-beta signaling pathway_Homo sapiens_hsa043500.51592425
110Pancreatic secretion_Homo sapiens_hsa049720.51538485
111Colorectal cancer_Homo sapiens_hsa052100.50097416
112Alcoholism_Homo sapiens_hsa050340.49887330
113Regulation of actin cytoskeleton_Homo sapiens_hsa048100.48152931
114Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.47411706
115Sphingolipid signaling pathway_Homo sapiens_hsa040710.46574964
116Cyanoamino acid metabolism_Homo sapiens_hsa004600.46100592
117Arginine biosynthesis_Homo sapiens_hsa002200.45531523
118Ovarian steroidogenesis_Homo sapiens_hsa049130.44512688
119Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.44162854
120Vibrio cholerae infection_Homo sapiens_hsa051100.43911196
121Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.41785986
122PI3K-Akt signaling pathway_Homo sapiens_hsa041510.41716426
123Insulin resistance_Homo sapiens_hsa049310.40651696
124Carbohydrate digestion and absorption_Homo sapiens_hsa049730.40094478
125Phototransduction_Homo sapiens_hsa047440.39565595

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