DMXL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the WD repeat superfamily of proteins, which have regulatory functions. This gene is expressed in many tissue types including several types of eye tissue, and it has been associated with ocular phenotypes. In addition, it is upregulated in cultured cells that overexpress growth factor independence 1B, a transcription factor that is essential for hematopoietic cell development. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1iron ion import (GO:0097286)5.13103590
2cellular response to ethanol (GO:0071361)4.77447447
3interkinetic nuclear migration (GO:0022027)4.54149309
4nuclear pore complex assembly (GO:0051292)4.51349512
5activated T cell proliferation (GO:0050798)4.38205546
6histone H3-K4 trimethylation (GO:0080182)4.11631903
7cytoplasmic mRNA processing body assembly (GO:0033962)4.10579124
8pre-miRNA processing (GO:0031054)4.10063254
9monoubiquitinated protein deubiquitination (GO:0035520)4.01480188
10negative regulation of translation involved in gene silencing by miRNA (GO:0035278)4.00136661
11negative regulation of translation, ncRNA-mediated (GO:0040033)4.00136661
12regulation of translation, ncRNA-mediated (GO:0045974)4.00136661
13negative regulation of fatty acid transport (GO:2000192)3.93895932
14antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.87241564
15lipid translocation (GO:0034204)3.85562363
16phospholipid translocation (GO:0045332)3.85562363
17mature B cell differentiation (GO:0002335)3.82689483
18nuclear pore organization (GO:0006999)3.67715594
19negative regulation of DNA repair (GO:0045738)3.63880945
20Golgi to endosome transport (GO:0006895)3.63512698
21import into cell (GO:0098657)3.60354538
22regulation of interleukin-12 biosynthetic process (GO:0045075)3.56410453
23histone H3-K36 demethylation (GO:0070544)3.50551487
24cellular response to zinc ion (GO:0071294)3.48981650
25regulation of interferon-beta biosynthetic process (GO:0045357)3.44548751
26retrograde transport, vesicle recycling within Golgi (GO:0000301)3.42494858
27germ cell migration (GO:0008354)3.42426839
28establishment of protein localization to Golgi (GO:0072600)3.37534074
29protein targeting to Golgi (GO:0000042)3.36059112
30positive regulation of gamma-delta T cell activation (GO:0046645)3.33150821
31regulation of pigment cell differentiation (GO:0050932)3.31229925
32positive regulation of fatty acid beta-oxidation (GO:0032000)3.29479993
33I-kappaB phosphorylation (GO:0007252)3.28018242
34protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)3.25097172
35regulation of B cell receptor signaling pathway (GO:0050855)3.24033326
36B cell receptor signaling pathway (GO:0050853)3.23867305
37nucleus localization (GO:0051647)3.23577874
38negative regulation of B cell proliferation (GO:0030889)3.22739171
39pore complex assembly (GO:0046931)3.22655683
40regulation of ARF protein signal transduction (GO:0032012)3.22405789
41positive regulation of developmental pigmentation (GO:0048087)3.21979483
42determination of adult lifespan (GO:0008340)3.20395922
43peptidyl-lysine trimethylation (GO:0018023)3.18863949
44mitochondrion distribution (GO:0048311)3.17122465
45glomerular visceral epithelial cell development (GO:0072015)3.15354442
46regulation of establishment of cell polarity (GO:2000114)3.13389081
47regulation of protein polyubiquitination (GO:1902914)3.13130864
48entry into other organism involved in symbiotic interaction (GO:0051828)3.11579534
49movement in host environment (GO:0052126)3.11579534
50entry into host cell (GO:0030260)3.11579534
51movement in environment of other organism involved in symbiotic interaction (GO:0052192)3.11579534
52entry into cell of other organism involved in symbiotic interaction (GO:0051806)3.11579534
53entry into host (GO:0044409)3.11579534
54negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.09835072
55negative regulation of cell killing (GO:0031342)3.09835072
56mitotic sister chromatid cohesion (GO:0007064)3.02243678
57regulation of fibroblast apoptotic process (GO:2000269)3.01225415
58locomotory exploration behavior (GO:0035641)2.98467868
59positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.96191048
60histone demethylation (GO:0016577)2.94941195
61nerve growth factor signaling pathway (GO:0038180)2.92752363
62negative regulation of neurotransmitter secretion (GO:0046929)2.85524620
63regulation of establishment or maintenance of cell polarity (GO:0032878)2.84595085
64protein K48-linked deubiquitination (GO:0071108)2.83540914
65regulation of RNA export from nucleus (GO:0046831)2.81891917
66phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.80423173
67peptidyl-lysine methylation (GO:0018022)2.79884426
68histone H3-K9 demethylation (GO:0033169)2.78903728
69negative regulation of histone methylation (GO:0031061)2.77911226
70definitive hemopoiesis (GO:0060216)2.76088964
71regulation of B cell apoptotic process (GO:0002902)2.74543165
72histone H3-K4 methylation (GO:0051568)2.73559407
73positive regulation of glycogen biosynthetic process (GO:0045725)2.71588493
74modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.71415053
75positive regulation by organism of defense response of other organism involved in symbiotic interact2.71415053
76modulation by symbiont of host immune response (GO:0052553)2.71415053
77positive regulation by symbiont of host defense response (GO:0052509)2.71415053
78modulation by symbiont of host defense response (GO:0052031)2.71415053
79modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.71415053
80regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.70813979
81branching involved in prostate gland morphogenesis (GO:0060442)2.70147224
82positive regulation of protein import into nucleus, translocation (GO:0033160)2.70040866
83regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.69554964
84positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.69554964
85myelin maintenance (GO:0043217)2.69406585
86phospholipid homeostasis (GO:0055091)2.69377470
87regulation of nucleobase-containing compound transport (GO:0032239)2.68558303
88negative regulation of toll-like receptor signaling pathway (GO:0034122)2.67638192
89insulin-like growth factor receptor signaling pathway (GO:0048009)2.67332304
90phosphatidylinositol dephosphorylation (GO:0046856)2.67011406
91histone mRNA catabolic process (GO:0071044)2.66254946
92positive thymic T cell selection (GO:0045059)2.66040877
93NLS-bearing protein import into nucleus (GO:0006607)2.65689596
94regulation of histone H3-K9 methylation (GO:0051570)2.63014847
95peptidyl-threonine phosphorylation (GO:0018107)2.62006600
96negative regulation of granulocyte differentiation (GO:0030853)2.60543784
97glomerular epithelial cell development (GO:0072310)2.60258130
98B cell proliferation (GO:0042100)2.59422089
99B cell homeostasis (GO:0001782)2.58955809
100T cell proliferation (GO:0042098)2.58887565
101peptidyl-lysine dimethylation (GO:0018027)2.56871139
102regulation of DNA endoreduplication (GO:0032875)2.56257757
103regulation of NFAT protein import into nucleus (GO:0051532)2.56243066
104regulation of gamma-delta T cell differentiation (GO:0045586)2.56145468
105regulation of B cell proliferation (GO:0030888)2.55098186
106peptidyl-threonine modification (GO:0018210)2.54577760
107epithelial cell differentiation involved in prostate gland development (GO:0060742)2.53650261
108phospholipid dephosphorylation (GO:0046839)2.53356684
109regulation of membrane lipid distribution (GO:0097035)2.52753529
110viral entry into host cell (GO:0046718)2.52645105
111positive regulation of DNA-templated transcription, initiation (GO:2000144)2.52444545
112JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.52114775
113response to lipoprotein particle (GO:0055094)2.51399240
114cytoskeletal anchoring at plasma membrane (GO:0007016)2.51055124
115establishment of nucleus localization (GO:0040023)2.50963870
116positive regulation of B cell differentiation (GO:0045579)2.50606342
117snRNA transcription (GO:0009301)2.49072282
118regulation of gamma-delta T cell activation (GO:0046643)2.48853844
119embryonic process involved in female pregnancy (GO:0060136)2.47648694
120histone lysine demethylation (GO:0070076)2.47631706
121protein targeting to lysosome (GO:0006622)2.47506667
122establishment of protein localization to vacuole (GO:0072666)2.47506667
123protein targeting to vacuole (GO:0006623)2.47506667
124regulation of histone H3-K27 methylation (GO:0061085)2.46968324
125early endosome to late endosome transport (GO:0045022)2.45907555
126protein localization to endosome (GO:0036010)2.45064254
127carnitine shuttle (GO:0006853)2.44622250
128positive regulation of cardiac muscle hypertrophy (GO:0010613)2.44575545
129positive regulation of muscle hypertrophy (GO:0014742)2.44575545
130COPII vesicle coating (GO:0048208)2.44531416
131positive regulation of oligodendrocyte differentiation (GO:0048714)2.43771206
132protein dealkylation (GO:0008214)2.43098886
133protein demethylation (GO:0006482)2.43098886
134lymphocyte proliferation (GO:0046651)2.41278333
135pinocytosis (GO:0006907)2.39960645
136Golgi to plasma membrane transport (GO:0006893)2.39043204
137cellular response to thyroid hormone stimulus (GO:0097067)2.38766173
138dosage compensation (GO:0007549)2.38730887
139mononuclear cell proliferation (GO:0032943)2.38436362
140positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.36825629
141regulation of transforming growth factor beta2 production (GO:0032909)2.36349592
142positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.34938986
143regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.34938986
144regulation of clathrin-mediated endocytosis (GO:2000369)2.34900726
145positive T cell selection (GO:0043368)2.34074376
146positive regulation of interleukin-2 production (GO:0032743)2.33108234
147positive regulation of macrophage cytokine production (GO:0060907)2.33099804
148intracellular lipid transport (GO:0032365)2.32835671
149regulation of Rac protein signal transduction (GO:0035020)2.32753399
150cerebellar Purkinje cell differentiation (GO:0021702)2.31762587
151Golgi organization (GO:0007030)2.29364217
152histone lysine methylation (GO:0034968)2.29227413
153regulation of germinal center formation (GO:0002634)2.28649177
154corticosteroid receptor signaling pathway (GO:0031958)2.28072209
155nucleus organization (GO:0006997)2.26755120
156dicarboxylic acid biosynthetic process (GO:0043650)2.26624618
157interleukin-6-mediated signaling pathway (GO:0070102)2.26288818
158embryonic camera-type eye morphogenesis (GO:0048596)2.25984680
159Rap protein signal transduction (GO:0032486)2.24566630
160platelet-derived growth factor receptor signaling pathway (GO:0048008)2.24380670
161microtubule anchoring (GO:0034453)2.24238524
162phosphatidylinositol phosphorylation (GO:0046854)2.23832771
163oligosaccharide catabolic process (GO:0009313)2.20153654
164genitalia morphogenesis (GO:0035112)2.19827476
165positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)2.19470099
166macroautophagy (GO:0016236)2.19083961
167fibroblast migration (GO:0010761)2.15210461
168positive regulation of cellular amide metabolic process (GO:0034250)2.14357027
169labyrinthine layer development (GO:0060711)2.14111902

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.72157810
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.47215108
3GATA1_22025678_ChIP-Seq_K562_Human3.33775965
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.06271434
5CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.86840903
6SALL1_21062744_ChIP-ChIP_HESCs_Human2.84916013
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.55810276
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.44472037
9SMAD_19615063_ChIP-ChIP_OVARY_Human2.19243197
10IRF8_22096565_ChIP-ChIP_GC-B_Human2.18436952
11TP53_16413492_ChIP-PET_HCT116_Human2.07425498
12EGR1_19374776_ChIP-ChIP_THP-1_Human2.05705728
13ZNF217_24962896_ChIP-Seq_MCF-7_Human1.97478791
14* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.93144234
15STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.84560251
16Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.83923572
17RUNX_20019798_ChIP-Seq_JUKART_Human1.80348888
18AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.75933433
19ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.75856670
20POU3F2_20337985_ChIP-ChIP_501MEL_Human1.73573183
21VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.70850733
22GBX2_23144817_ChIP-Seq_PC3_Human1.69789944
23FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.66821809
24ESR1_20079471_ChIP-ChIP_T-47D_Human1.65322756
25SCL_19346495_ChIP-Seq_HPC-7_Human1.64348212
26PIAS1_25552417_ChIP-Seq_VCAP_Human1.63987539
27SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.61140137
28CTNNB1_20460455_ChIP-Seq_HCT116_Human1.56857457
29IRF8_27001747_Chip-Seq_BMDM_Mouse1.56359064
30IGF1R_20145208_ChIP-Seq_DFB_Human1.49851327
31MYB_21317192_ChIP-Seq_ERMYB_Mouse1.49793923
32EZH2_22144423_ChIP-Seq_EOC_Human1.48081672
33* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.43559149
34AR_21909140_ChIP-Seq_LNCAP_Human1.42867471
35STAT3_23295773_ChIP-Seq_U87_Human1.40968327
36CDX2_19796622_ChIP-Seq_MESCs_Mouse1.40568965
37AHR_22903824_ChIP-Seq_MCF-7_Human1.40323325
38AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.39728677
39CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.38986144
40FOXO3_23340844_ChIP-Seq_DLD1_Human1.38473642
41ARNT_22903824_ChIP-Seq_MCF-7_Human1.38333542
42NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.37754517
43* POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.34185981
44* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34185981
45FUS_26573619_Chip-Seq_HEK293_Human1.32978168
46ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.32909911
47EP300_21415370_ChIP-Seq_HL-1_Mouse1.31813196
48AR_21572438_ChIP-Seq_LNCaP_Human1.31683313
49SMAD4_21799915_ChIP-Seq_A2780_Human1.31445756
50* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.30912971
51FOXM1_26456572_ChIP-Seq_MCF-7_Human1.30402434
52PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.30357477
53STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.29821284
54SALL4_18804426_ChIP-ChIP_XEN_Mouse1.28710905
55* P300_19829295_ChIP-Seq_ESCs_Human1.28688852
56NR3C1_21868756_ChIP-Seq_MCF10A_Human1.26868337
57PCGF2_27294783_Chip-Seq_NPCs_Mouse1.26318051
58* EWS_26573619_Chip-Seq_HEK293_Human1.25198145
59SMAD3_21741376_ChIP-Seq_EPCs_Human1.24946376
60* TCF4_23295773_ChIP-Seq_U87_Human1.23673455
61FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.23058418
62VDR_24787735_ChIP-Seq_THP-1_Human1.22746794
63TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.21747697
64GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20416053
65GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.20225225
66TCF4_18268006_ChIP-ChIP_LS174T_Human1.20125659
67PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.18647991
68ZFP57_27257070_Chip-Seq_ESCs_Mouse1.17723926
69FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.17719048
70OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17704832
71HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.17423772
72SOX2_21211035_ChIP-Seq_LN229_Gbm1.17215041
73FLI1_27457419_Chip-Seq_LIVER_Mouse1.16128085
74PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.14241707
75FOXA2_19822575_ChIP-Seq_HepG2_Human1.14175176
76SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.13531035
77BCAT_22108803_ChIP-Seq_LS180_Human1.13433517
78RXR_22108803_ChIP-Seq_LS180_Human1.13143812
79TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.12522985
80NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.12375580
81SOX9_24532713_ChIP-Seq_HFSC_Mouse1.10444860
82DROSHA_22980978_ChIP-Seq_HELA_Human1.09297958
83SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.09163247
84TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.08975442
85FOXM1_23109430_ChIP-Seq_U2OS_Human1.08022235
86NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.07815016
87PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07696348
88ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.06919079
89NANOG_18555785_Chip-Seq_ESCs_Mouse1.04719595
90FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.04455038
91* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.03253028
92RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.02370805
93TP53_18474530_ChIP-ChIP_U2OS_Human1.02362463
94PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.02269448
95FOXA1_25552417_ChIP-Seq_VCAP_Human1.02258115
96ESR1_21235772_ChIP-Seq_MCF-7_Human1.01922989
97TAF15_26573619_Chip-Seq_HEK293_Human1.01261719
98E2F7_22180533_ChIP-Seq_HELA_Human1.00355690
99* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.00231712
100SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99381338
101TP63_23658742_ChIP-Seq_EP156T_Human0.98978492
102SUZ12_27294783_Chip-Seq_NPCs_Mouse0.98337506
103DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.98044644
104GATA2_19941826_ChIP-Seq_K562_Human0.97909467
105SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.96014876
106SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.96014876
107WT1_19549856_ChIP-ChIP_CCG9911_Human0.95951299
108CTBP1_25329375_ChIP-Seq_LNCAP_Human0.95837983
109CMYC_18555785_Chip-Seq_ESCs_Mouse0.95775112
110NR3C1_23031785_ChIP-Seq_PC12_Mouse0.95001972
111AR_25329375_ChIP-Seq_VCAP_Human0.94588604
112GATA2_21666600_ChIP-Seq_HMVEC_Human0.93740563
113BRD4_25478319_ChIP-Seq_HGPS_Human0.92459947
114ER_23166858_ChIP-Seq_MCF-7_Human0.91592412
115MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.91545667
116E2F1_18555785_Chip-Seq_ESCs_Mouse0.91133869
117* AR_19668381_ChIP-Seq_PC3_Human0.90759717
118SPI1_23127762_ChIP-Seq_K562_Human0.88523582
119CTBP2_25329375_ChIP-Seq_LNCAP_Human0.87376521
120* RUNX2_22187159_ChIP-Seq_PCA_Human0.87135463
121CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.87121198
122SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86950787
123WT1_25993318_ChIP-Seq_PODOCYTE_Human0.86757035
124* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.86401275
125PPAR_26484153_Chip-Seq_NCI-H1993_Human0.86353678
126EZH2_27294783_Chip-Seq_NPCs_Mouse0.84667823
127TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.84534717
128NRF2_20460467_ChIP-Seq_MEFs_Mouse0.84506898
129NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.84506898

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation7.90710992
2MP0008057_abnormal_DNA_replication3.96420601
3MP0002166_altered_tumor_susceptibility3.65201722
4MP0003787_abnormal_imprinting3.42478720
5MP0003300_gastrointestinal_ulcer3.31220758
6MP0005076_abnormal_cell_differentiation2.82482368
7MP0002006_tumorigenesis2.70359590
8MP0010234_abnormal_vibrissa_follicle2.69432506
9MP0002009_preneoplasia2.53313051
10MP0003183_abnormal_peptide_metabolism2.52154640
11MP0003172_abnormal_lysosome_physiology2.18796852
12MP0010352_gastrointestinal_tract_polyps2.15773310
13MP0003045_fibrosis2.14851852
14MP0010307_abnormal_tumor_latency2.13533296
15MP0001800_abnormal_humoral_immune2.12476763
16MP0005451_abnormal_body_composition2.07286371
17MP0002877_abnormal_melanocyte_morpholog2.05672163
18MP0001835_abnormal_antigen_presentation1.96139576
19MP0005409_darkened_coat_color1.92949739
20MP0003091_abnormal_cell_migration1.92539812
21MP0002254_reproductive_system_inflammat1.85241692
22MP0003303_peritoneal_inflammation1.83455022
23MP0005174_abnormal_tail_pigmentation1.75043582
24MP0002138_abnormal_hepatobiliary_system1.74541540
25MP0001790_abnormal_immune_system1.73682135
26MP0005387_immune_system_phenotype1.73682135
27MP0000015_abnormal_ear_pigmentation1.73238525
28MP0003950_abnormal_plasma_membrane1.68009944
29MP0008961_abnormal_basal_metabolism1.64107004
30MP0002928_abnormal_bile_duct1.61867391
31MP0009780_abnormal_chondrocyte_physiolo1.61478508
32MP0002452_abnormal_antigen_presenting1.55911379
33MP0004043_abnormal_pH_regulation1.54154869
34MP0005647_abnormal_sex_gland1.52376189
35MP0003705_abnormal_hypodermis_morpholog1.51638404
36MP0000465_gastrointestinal_hemorrhage1.49790264
37MP0000371_diluted_coat_color1.45314244
38MP0003656_abnormal_erythrocyte_physiolo1.39991279
39MP0010678_abnormal_skin_adnexa1.38223010
40MP0004510_myositis1.36141804
41MP0001851_eye_inflammation1.35984763
42MP0004036_abnormal_muscle_relaxation1.35013761
43MP0005408_hypopigmentation1.34921483
44MP0003690_abnormal_glial_cell1.31946099
45MP0008877_abnormal_DNA_methylation1.31332131
46MP0000372_irregular_coat_pigmentation1.23626877
47MP0005000_abnormal_immune_tolerance1.21099201
48MP0004859_abnormal_synaptic_plasticity1.19170651
49MP0003121_genomic_imprinting1.18936201
50MP0005220_abnormal_exocrine_pancreas1.17747822
51MP0001177_atelectasis1.17350258
52MP0002723_abnormal_immune_serum1.17329093
53MP0000733_abnormal_muscle_development1.16832763
54MP0005275_abnormal_skin_tensile1.16821997
55MP0002075_abnormal_coat/hair_pigmentati1.16508202
56MP0009115_abnormal_fat_cell1.15658073
57MP0002420_abnormal_adaptive_immunity1.13343710
58MP0003868_abnormal_feces_composition1.10952908
59MP0001819_abnormal_immune_cell1.10291171
60MP0002168_other_aberrant_phenotype1.09965291
61MP0002398_abnormal_bone_marrow1.09511514
62MP0010386_abnormal_urinary_bladder1.08378872
63MP0000427_abnormal_hair_cycle1.06097501
64MP0000685_abnormal_immune_system1.06037887
65MP0001186_pigmentation_phenotype1.05933224
66MP0003566_abnormal_cell_adhesion1.05880750
67MP0003632_abnormal_nervous_system1.04519309
68MP0001545_abnormal_hematopoietic_system1.03903393
69MP0005397_hematopoietic_system_phenotyp1.03903393
70MP0005167_abnormal_blood-brain_barrier1.03610610
71MP0001879_abnormal_lymphatic_vessel1.02600847
72MP0001915_intracranial_hemorrhage1.02035197
73MP0000003_abnormal_adipose_tissue1.01352239
74MP0002090_abnormal_vision0.99812824
75MP0004233_abnormal_muscle_weight0.99597977
76MP0001661_extended_life_span0.98820018
77MP0009697_abnormal_copulation0.98784712
78MP0005171_absent_coat_pigmentation0.98050206
79MP0002909_abnormal_adrenal_gland0.95041322
80MP0001873_stomach_inflammation0.94588463
81MP0002088_abnormal_embryonic_growth/wei0.94401600
82MP0004883_abnormal_blood_vessel0.94209011
83MP0003984_embryonic_growth_retardation0.93341576
84MP0000604_amyloidosis0.92563700
85MP0000716_abnormal_immune_system0.92167320
86MP0003890_abnormal_embryonic-extraembry0.91734970
87MP0009703_decreased_birth_body0.91695770
88MP0004084_abnormal_cardiac_muscle0.90403199
89MP0002998_abnormal_bone_remodeling0.89771932
90MP0008569_lethality_at_weaning0.88011376
91MP0005621_abnormal_cell_physiology0.87666835
92MP0000689_abnormal_spleen_morphology0.87290088
93MP0003828_pulmonary_edema0.86743584
94MP0001299_abnormal_eye_distance/0.86092005
95MP0004197_abnormal_fetal_growth/weight/0.85754606
96MP0000703_abnormal_thymus_morphology0.85662632
97MP0000383_abnormal_hair_follicle0.83489168
98MP0003221_abnormal_cardiomyocyte_apopto0.82398598
99MP0002086_abnormal_extraembryonic_tissu0.80013303
100MP0003191_abnormal_cellular_cholesterol0.79872561
101MP0005671_abnormal_response_to0.79784117
102MP0004381_abnormal_hair_follicle0.79623971
103MP0003453_abnormal_keratinocyte_physiol0.78749086
104MP0003252_abnormal_bile_duct0.78348958
105MP0002133_abnormal_respiratory_system0.77767039
106MP0005388_respiratory_system_phenotype0.77767039
107MP0002419_abnormal_innate_immunity0.75240209
108MP0002136_abnormal_kidney_physiology0.75132888
109MP0003941_abnormal_skin_development0.74403433
110MP0004130_abnormal_muscle_cell0.74341663
111MP0006054_spinal_hemorrhage0.73821073
112MP0003763_abnormal_thymus_physiology0.73645139
113MP0000920_abnormal_myelination0.73086131
114MP0000537_abnormal_urethra_morphology0.72126042
115MP0004185_abnormal_adipocyte_glucose0.70973410
116MP0002396_abnormal_hematopoietic_system0.69627098
117MP0001672_abnormal_embryogenesis/_devel0.69480962
118MP0005380_embryogenesis_phenotype0.69480962
119MP0005384_cellular_phenotype0.69331540
120MP0004947_skin_inflammation0.68014894
121MP0008004_abnormal_stomach_pH0.67931984
122MP0004264_abnormal_extraembryonic_tissu0.67925736
123MP0005395_other_phenotype0.67418103
124MP0005310_abnormal_salivary_gland0.67354784
125MP0003631_nervous_system_phenotype0.66257717
126MP0004808_abnormal_hematopoietic_stem0.65655211
127MP0004134_abnormal_chest_morphology0.65298338
128MP0002722_abnormal_immune_system0.64908526
129MP0005375_adipose_tissue_phenotype0.64086996
130MP0003436_decreased_susceptibility_to0.63227966
131MP0004885_abnormal_endolymph0.63163847
132MP0005666_abnormal_adipose_tissue0.62923979
133MP0001958_emphysema0.60755451
134MP0000350_abnormal_cell_proliferation0.60690986
135MP0000377_abnormal_hair_follicle0.60417732
136MP0002095_abnormal_skin_pigmentation0.60343703
137MP0004742_abnormal_vestibular_system0.59793380
138MP0001784_abnormal_fluid_regulation0.59649031
139MP0001191_abnormal_skin_condition0.58663703
140MP0002429_abnormal_blood_cell0.58395809
141MP0003633_abnormal_nervous_system0.58304940
142MP0010630_abnormal_cardiac_muscle0.57552258
143MP0000428_abnormal_craniofacial_morphol0.57529679
144MP0005248_abnormal_Harderian_gland0.56957449
145MP0002925_abnormal_cardiovascular_devel0.56718062
146MP0005464_abnormal_platelet_physiology0.56666003

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the fingertips (HP:0001211)3.70964232
2Macroorchidism (HP:0000053)3.46346400
3Dysmetric saccades (HP:0000641)3.45130985
4Hematochezia (HP:0002573)3.45004895
5Absent frontal sinuses (HP:0002688)3.35385698
6Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.35280799
7Volvulus (HP:0002580)3.18193485
8Acute myeloid leukemia (HP:0004808)3.11378888
9Thyroiditis (HP:0100646)3.02075261
10Thyroid carcinoma (HP:0002890)2.95024002
11Aqueductal stenosis (HP:0002410)2.88534576
12Overgrowth (HP:0001548)2.86311621
13Resting tremor (HP:0002322)2.78193807
14Colitis (HP:0002583)2.70309661
15Abnormality of the axillary hair (HP:0100134)2.69244367
16Abnormality of secondary sexual hair (HP:0009888)2.69244367
17Transitional cell carcinoma of the bladder (HP:0006740)2.61258310
18Abnormality of the nasal septum (HP:0000419)2.58270236
19Generalized hypopigmentation of hair (HP:0011358)2.57861400
20Heterotopia (HP:0002282)2.55777564
21Scanning speech (HP:0002168)2.52620249
22Blue irides (HP:0000635)2.52516048
23Curly hair (HP:0002212)2.52457421
24Small epiphyses (HP:0010585)2.50961926
25Abnormality of the vasculature of the conjunctiva (HP:0008054)2.47774414
26Narrow palate (HP:0000189)2.47675401
27Fair hair (HP:0002286)2.45453347
28Bladder carcinoma (HP:0002862)2.44719687
29Bladder neoplasm (HP:0009725)2.44719687
30Spontaneous hematomas (HP:0007420)2.35807891
31Deep philtrum (HP:0002002)2.31102096
32Relative macrocephaly (HP:0004482)2.30235423
33Rhabdomyosarcoma (HP:0002859)2.27449316
34Medulloblastoma (HP:0002885)2.26498796
35Subacute progressive viral hepatitis (HP:0006572)2.25101189
36Excessive salivation (HP:0003781)2.22494343
37Drooling (HP:0002307)2.22494343
38Vertebral arch anomaly (HP:0008438)2.21924296
39Conjunctival telangiectasia (HP:0000524)2.21736879
40Cerebral aneurysm (HP:0004944)2.19804674
41Arterial tortuosity (HP:0005116)2.18639462
42Hyperventilation (HP:0002883)2.18517772
43Aortic aneurysm (HP:0004942)2.18003898
44Termporal pattern (HP:0011008)2.17506702
45Insidious onset (HP:0003587)2.17506702
46Truncal obesity (HP:0001956)2.16921657
47Hypopigmentation of the fundus (HP:0007894)2.16654561
48Papillary thyroid carcinoma (HP:0002895)2.15584160
49Febrile seizures (HP:0002373)2.15357941
50Myocardial infarction (HP:0001658)2.14808081
51Increased CSF protein (HP:0002922)2.12360631
52Recurrent viral infections (HP:0004429)2.11427825
53B lymphocytopenia (HP:0010976)2.10585055
54Abnormality of B cell number (HP:0010975)2.10585055
55Neonatal hypoglycemia (HP:0001998)2.09581200
56Hypochromic microcytic anemia (HP:0004840)2.07500107
57Postural instability (HP:0002172)2.06340629
58Osteolytic defects of the hand bones (HP:0009699)2.06143736
59Osteolytic defects of the phalanges of the hand (HP:0009771)2.06143736
60Short chin (HP:0000331)2.05854610
61Limited elbow extension (HP:0001377)2.04435453
62Agammaglobulinemia (HP:0004432)2.03154700
63Chronic diarrhea (HP:0002028)2.03073259
64Germ cell neoplasia (HP:0100728)2.02393279
65Cubitus valgus (HP:0002967)2.01923023
66Gaze-evoked nystagmus (HP:0000640)2.01621099
67Biliary tract neoplasm (HP:0100574)2.01131092
68Protruding tongue (HP:0010808)1.99359585
69Abnormality of the periventricular white matter (HP:0002518)1.99137218
70Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.98788882
71Urinary bladder sphincter dysfunction (HP:0002839)1.98370907
72Hypoplasia of the thymus (HP:0000778)1.98265489
73Submucous cleft hard palate (HP:0000176)1.98023181
74Hypoplastic ischia (HP:0003175)1.97954033
75Large earlobe (HP:0009748)1.97007894
76Inflammation of the large intestine (HP:0002037)1.96877048
77Lower limb amyotrophy (HP:0007210)1.94948877
78Widely spaced teeth (HP:0000687)1.94924591
79Flat acetabular roof (HP:0003180)1.94149859
80Spinal muscular atrophy (HP:0007269)1.93442808
81Verrucae (HP:0200043)1.92893274
82Papilloma (HP:0012740)1.92893274
83Recurrent bacterial skin infections (HP:0005406)1.92686159
84Gastrointestinal stroma tumor (HP:0100723)1.90821388
85Sparse lateral eyebrow (HP:0005338)1.89239862
86Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.87849300
87Periodontitis (HP:0000704)1.87831791
88Low anterior hairline (HP:0000294)1.85721649
89Neoplasm of striated muscle (HP:0009728)1.84284837
90Syringomyelia (HP:0003396)1.84086020
91Spinal cord lesions (HP:0100561)1.84086020
92Hypoplastic labia majora (HP:0000059)1.83534488
93Mitral valve prolapse (HP:0001634)1.82843410
94Viral hepatitis (HP:0006562)1.82448636
95Mediastinal lymphadenopathy (HP:0100721)1.82087740
96Vascular tortuosity (HP:0004948)1.81860652
97Persistence of primary teeth (HP:0006335)1.81684357
98Tapered finger (HP:0001182)1.81334724
99Abnormality of salivation (HP:0100755)1.81324322
100Abnormality of the frontal sinuses (HP:0002687)1.80960372
101Neoplasm of the heart (HP:0100544)1.80922883
102Abnormality of the epiphyses of the hand (HP:0005924)1.80846946
103Coarse hair (HP:0002208)1.80750088
104Sandal gap (HP:0001852)1.79804235
105Abnormality of the right ventricle (HP:0001707)1.79425139
106Ulnar bowing (HP:0003031)1.78887976
107Anal stenosis (HP:0002025)1.78829209
108Neoplasm of the tracheobronchial system (HP:0100552)1.77608965
109Lip pit (HP:0100267)1.77384656
110Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.77247153
111Mitral stenosis (HP:0001718)1.77244621
112Distal lower limb amyotrophy (HP:0008944)1.76323764
113Inappropriate behavior (HP:0000719)1.76098223
114Oligodactyly (hands) (HP:0001180)1.75025181
115Esophageal varix (HP:0002040)1.74575743
116Urinary urgency (HP:0000012)1.74235804
117Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.73606642
118Cystic hygroma (HP:0000476)1.72538338
119Urethral obstruction (HP:0000796)1.72503773
120Neoplasm of the adrenal cortex (HP:0100641)1.71919540
121Impaired vibratory sensation (HP:0002495)1.71289339
122Abnormality of the ischium (HP:0003174)1.71181147
123Slow saccadic eye movements (HP:0000514)1.70946835
124Chronic hepatic failure (HP:0100626)1.70154355
125IgA deficiency (HP:0002720)1.68257205
126Gastrointestinal inflammation (HP:0004386)1.67990604
127Malignant gastrointestinal tract tumors (HP:0006749)1.67886155
128Gastrointestinal carcinoma (HP:0002672)1.67886155
129Uterine leiomyosarcoma (HP:0002891)1.67734995
130Leiomyosarcoma (HP:0100243)1.67734995
131T lymphocytopenia (HP:0005403)1.67124049
132Hypoplasia of the iris (HP:0007676)1.66936225
133Abnormality of the distal phalanx of the thumb (HP:0009617)1.66324093
134Thick eyebrow (HP:0000574)1.66116335
135Pheochromocytoma (HP:0002666)1.65422484
136Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.65232827
137Prominent nose (HP:0000448)1.64678793
138Thoracolumbar scoliosis (HP:0002944)1.63955734
139Astrocytoma (HP:0009592)1.63785990
140Abnormality of the astrocytes (HP:0100707)1.63785990
141Gingivitis (HP:0000230)1.63566643
142Global brain atrophy (HP:0002283)1.62749470
143Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.62126094
144Arterial thrombosis (HP:0004420)1.61139828
145Genetic anticipation (HP:0003743)1.60622074
146Pulmonic stenosis (HP:0001642)1.60330427
147Long eyelashes (HP:0000527)1.59850967
148Disinhibition (HP:0000734)1.58585017
149Lower limb muscle weakness (HP:0007340)1.58509739
150Recurrent fungal infections (HP:0002841)1.58274617
151Abnormality of the labia majora (HP:0012881)1.56906500
152Abnormality of T cell number (HP:0011839)1.56332229
153Lower limb hyperreflexia (HP:0002395)1.55753015
154Osteomyelitis (HP:0002754)1.55103753
155Eczematoid dermatitis (HP:0000976)1.52943998
156Hemangiomatosis (HP:0007461)1.52900391
157Cellulitis (HP:0100658)1.52746153

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.49883003
2CDK123.44166731
3GRK63.22725061
4EEF2K2.58985466
5CAMK1D2.52852187
6SCYL22.41025005
7CAMK1G2.40324822
8RIPK42.26636237
9BRD42.24591527
10ACVR1B2.22305837
11MAP3K132.08779833
12FGFR22.03923204
13NEK91.88006315
14FGFR31.82129311
15LATS11.78957922
16PDGFRB1.74734978
17BMPR21.72940050
18WNK11.71793649
19SGK21.62900759
20SGK31.57215362
21MAP3K141.56523357
22PIK3CG1.55932152
23PKN21.53332071
24BLK1.51914156
25TRPM71.50660325
26JAK11.49681181
27NLK1.34543325
28MAP3K21.33680234
29INSRR1.31508987
30MELK1.31440638
31PDGFRA1.31302391
32SIK21.30771155
33EIF2AK31.29056787
34TTN1.27458547
35CDK91.26892173
36CHUK1.20840944
37MST41.19738677
38FER1.16887870
39PRPF4B1.12964703
40MAP3K71.09482106
41SIK11.09436893
42HCK1.08492491
43NUAK11.08117742
44MAPK71.06175834
45SGK2231.00940428
46SGK4941.00940428
47SGK10.97653224
48PTK60.97612144
49JAK20.96995719
50IKBKB0.96760923
51MAP3K40.95440876
52NTRK30.95085831
53STK100.94865809
54PIM10.94423116
55CSF1R0.93298853
56ZAK0.90682202
57MAP4K10.90180181
58STK390.89778037
59CDK60.89571709
60TYK20.89461727
61IRAK30.89442280
62MTOR0.89312778
63EPHA30.88966942
64LMTK20.88747149
65ERBB20.86964231
66LRRK20.86569441
67MAP3K100.85353229
68TGFBR20.82270244
69BTK0.81712299
70ITK0.81554336
71YES10.78475448
72GSK3A0.78352727
73CAMKK20.77482023
74TAOK30.76780140
75CSNK1A1L0.75088032
76CCNB10.74935134
77OBSCN0.74537355
78PRKCQ0.74056339
79CSK0.73746770
80PKN10.73515527
81PDK10.72619866
82STK38L0.72353834
83INSR0.70236892
84PRKAA20.70027196
85RIPK10.69360292
86KSR20.68519425
87MAPK100.67355872
88HIPK20.66629917
89IRAK10.65883160
90STK30.65476646
91CSNK1D0.65162227
92TRIB30.64763527
93PRKDC0.64201107
94FES0.64030328
95TEC0.62176804
96CSNK1G20.61651956
97CAMK40.60660886
98CDC42BPA0.60289872
99AKT30.60090098
100RPS6KB10.59770464
101STK240.59089600
102EGFR0.58463791
103BRSK20.57793951
104EPHB10.57414244
105RPS6KB20.56243647
106IRAK20.55360618
107GRK10.54860678
108TNIK0.54784026
109MARK20.54585805
110FGFR40.54404114
111STK110.53961466
112RPS6KA30.53518756
113ERBB30.52809774
114ATM0.51818198
115MAP3K90.51510348
116ROCK20.50900175
117ALK0.50852420
118MAP3K60.50674683
119BMPR1B0.49739613
120SYK0.49608944
121PDPK10.49517161
122PDK20.49141379
123MAPK110.48406751
124DMPK0.47502659
125MAPK120.47425650
126ATR0.46822233
127RAF10.46291988
128OXSR10.46061374
129JAK30.45980300
130PNCK0.45626390
131PIK3CA0.45468365
132TNK20.44933014
133MAPK80.44856661
134PRKAA10.44844011
135IKBKE0.44411452
136MAPK140.44132845
137FYN0.43882014
138ICK0.43349926
139RET0.43256344
140NEK60.42517909
141PRKCH0.42014744
142CHEK10.41143526
143CDK40.39170254
144MAPK10.34116140

Predicted pathways (KEGG)

RankGene SetZ-score
1B cell receptor signaling pathway_Homo sapiens_hsa046622.55927569
2Type II diabetes mellitus_Homo sapiens_hsa049302.23123275
3Phosphatidylinositol signaling system_Homo sapiens_hsa040701.86997398
4Dorso-ventral axis formation_Homo sapiens_hsa043201.83772708
5Lysine degradation_Homo sapiens_hsa003101.65427990
6Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.55186846
7Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.49011455
8Osteoclast differentiation_Homo sapiens_hsa043801.43278059
9MicroRNAs in cancer_Homo sapiens_hsa052061.37999904
10mTOR signaling pathway_Homo sapiens_hsa041501.37661485
11NF-kappa B signaling pathway_Homo sapiens_hsa040641.35361061
12Inositol phosphate metabolism_Homo sapiens_hsa005621.34927966
13Prolactin signaling pathway_Homo sapiens_hsa049171.31075051
14Long-term potentiation_Homo sapiens_hsa047201.28536630
15Fatty acid biosynthesis_Homo sapiens_hsa000611.27490992
16Insulin resistance_Homo sapiens_hsa049311.20224656
17Systemic lupus erythematosus_Homo sapiens_hsa053221.18023917
18T cell receptor signaling pathway_Homo sapiens_hsa046601.15084466
19FoxO signaling pathway_Homo sapiens_hsa040681.14113622
20Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.12781231
21Chronic myeloid leukemia_Homo sapiens_hsa052201.12236024
22Glioma_Homo sapiens_hsa052141.12135013
23Renin secretion_Homo sapiens_hsa049241.10334157
24Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.09710053
25Thyroid cancer_Homo sapiens_hsa052161.07507199
26Pancreatic cancer_Homo sapiens_hsa052121.06781511
27Thyroid hormone signaling pathway_Homo sapiens_hsa049191.04283291
28Intestinal immune network for IgA production_Homo sapiens_hsa046721.03739401
29Chemokine signaling pathway_Homo sapiens_hsa040621.03508236
30Choline metabolism in cancer_Homo sapiens_hsa052311.02980428
31Nitrogen metabolism_Homo sapiens_hsa009101.02321009
32Adipocytokine signaling pathway_Homo sapiens_hsa049201.01189874
33Transcriptional misregulation in cancer_Homo sapiens_hsa052021.01138954
34NOD-like receptor signaling pathway_Homo sapiens_hsa046211.00095667
35Carbohydrate digestion and absorption_Homo sapiens_hsa049730.99165330
36Jak-STAT signaling pathway_Homo sapiens_hsa046300.99059418
37Longevity regulating pathway - mammal_Homo sapiens_hsa042110.98936499
38cGMP-PKG signaling pathway_Homo sapiens_hsa040220.98021234
39Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.95530070
40Proteoglycans in cancer_Homo sapiens_hsa052050.95416745
41Small cell lung cancer_Homo sapiens_hsa052220.95382609
42Adherens junction_Homo sapiens_hsa045200.94824553
43Non-small cell lung cancer_Homo sapiens_hsa052230.94619917
44Morphine addiction_Homo sapiens_hsa050320.94565541
45Aldosterone synthesis and secretion_Homo sapiens_hsa049250.94550570
46ErbB signaling pathway_Homo sapiens_hsa040120.94323914
47Primary immunodeficiency_Homo sapiens_hsa053400.93184538
48Phospholipase D signaling pathway_Homo sapiens_hsa040720.90593912
49Prostate cancer_Homo sapiens_hsa052150.88988456
50Circadian entrainment_Homo sapiens_hsa047130.88844618
51Oxytocin signaling pathway_Homo sapiens_hsa049210.88052265
52Gastric acid secretion_Homo sapiens_hsa049710.87805635
53Salivary secretion_Homo sapiens_hsa049700.87286870
54Long-term depression_Homo sapiens_hsa047300.86743685
55Neurotrophin signaling pathway_Homo sapiens_hsa047220.86466728
56Leukocyte transendothelial migration_Homo sapiens_hsa046700.86448216
57Endometrial cancer_Homo sapiens_hsa052130.85068206
58Sphingolipid signaling pathway_Homo sapiens_hsa040710.84614811
59Cholinergic synapse_Homo sapiens_hsa047250.82885170
60Hepatitis B_Homo sapiens_hsa051610.82726274
61Toll-like receptor signaling pathway_Homo sapiens_hsa046200.81121439
62Estrogen signaling pathway_Homo sapiens_hsa049150.80500483
63Renal cell carcinoma_Homo sapiens_hsa052110.79671892
64Renin-angiotensin system_Homo sapiens_hsa046140.79371796
65cAMP signaling pathway_Homo sapiens_hsa040240.79336116
66Glutamatergic synapse_Homo sapiens_hsa047240.79004282
67MAPK signaling pathway_Homo sapiens_hsa040100.77634837
68Non-homologous end-joining_Homo sapiens_hsa034500.76958422
69Tuberculosis_Homo sapiens_hsa051520.76694016
70Platelet activation_Homo sapiens_hsa046110.76627447
71Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.75492495
72GnRH signaling pathway_Homo sapiens_hsa049120.75226975
73Toxoplasmosis_Homo sapiens_hsa051450.75049312
74AMPK signaling pathway_Homo sapiens_hsa041520.74132561
75Vascular smooth muscle contraction_Homo sapiens_hsa042700.74125817
76Viral carcinogenesis_Homo sapiens_hsa052030.73823241
77Staphylococcus aureus infection_Homo sapiens_hsa051500.73392103
78Lysosome_Homo sapiens_hsa041420.73229655
79Insulin signaling pathway_Homo sapiens_hsa049100.72539538
80Insulin secretion_Homo sapiens_hsa049110.72132762
81Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.72005247
82Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.71696440
83Nicotine addiction_Homo sapiens_hsa050330.71690829
84AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.71507628
85Other glycan degradation_Homo sapiens_hsa005110.71443822
86Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.70564587
87HIF-1 signaling pathway_Homo sapiens_hsa040660.70306143
88Glucagon signaling pathway_Homo sapiens_hsa049220.70025005
89Colorectal cancer_Homo sapiens_hsa052100.69819658
90Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.69309484
91Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.68893589
92Hematopoietic cell lineage_Homo sapiens_hsa046400.68650365
93Regulation of actin cytoskeleton_Homo sapiens_hsa048100.68179214
94Focal adhesion_Homo sapiens_hsa045100.67992206
95TGF-beta signaling pathway_Homo sapiens_hsa043500.67935275
96Acute myeloid leukemia_Homo sapiens_hsa052210.67669150
97Influenza A_Homo sapiens_hsa051640.67261052
98Alcoholism_Homo sapiens_hsa050340.66344469
99Hepatitis C_Homo sapiens_hsa051600.65983979
100VEGF signaling pathway_Homo sapiens_hsa043700.65867827
101Amoebiasis_Homo sapiens_hsa051460.64194012
102Pancreatic secretion_Homo sapiens_hsa049720.64032613
103Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.64014308
104Measles_Homo sapiens_hsa051620.63267132
105Amphetamine addiction_Homo sapiens_hsa050310.62940236
106Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.62697206
107GABAergic synapse_Homo sapiens_hsa047270.62138743
108Endocytosis_Homo sapiens_hsa041440.61972278
109Leishmaniasis_Homo sapiens_hsa051400.61608035
110Axon guidance_Homo sapiens_hsa043600.61551266
111Asthma_Homo sapiens_hsa053100.61402073
112ABC transporters_Homo sapiens_hsa020100.61217201
113Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.61073778
114TNF signaling pathway_Homo sapiens_hsa046680.60056084
115Thyroid hormone synthesis_Homo sapiens_hsa049180.58675045
116Circadian rhythm_Homo sapiens_hsa047100.57974617
117Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.57514122
118Dopaminergic synapse_Homo sapiens_hsa047280.57003956
119Calcium signaling pathway_Homo sapiens_hsa040200.56756035
120Melanoma_Homo sapiens_hsa052180.56662843
121ECM-receptor interaction_Homo sapiens_hsa045120.55970653
122Sphingolipid metabolism_Homo sapiens_hsa006000.55095498
123Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.54661583
124Gap junction_Homo sapiens_hsa045400.53667730
125RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.50952637
126Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.50804790
127Herpes simplex infection_Homo sapiens_hsa051680.50687548
128Primary bile acid biosynthesis_Homo sapiens_hsa001200.46027481

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »