DNA2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the DNA2/NAM7 helicase family. The encoded protein is a conserved helicase/nuclease involved in the maintenance of mitochondrial and nuclear DNA stability. Mutations in this gene are associated with autosomal dominant progressive external ophthalmoplegia-6 (PEOA6) and Seckel syndrome 8. Alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)5.48216770
2DNA replication initiation (GO:0006270)5.40699196
3* DNA strand elongation involved in DNA replication (GO:0006271)5.40698689
4* DNA strand elongation (GO:0022616)5.17709269
5* telomere maintenance via semi-conservative replication (GO:0032201)5.14452812
6regulation of DNA endoreduplication (GO:0032875)5.07380309
7protein localization to kinetochore (GO:0034501)4.81500566
8* telomere maintenance via recombination (GO:0000722)4.73759881
9* DNA replication checkpoint (GO:0000076)4.67228284
10* mitotic recombination (GO:0006312)4.59660486
11regulation of centriole replication (GO:0046599)4.24782186
12nuclear pore organization (GO:0006999)4.22439467
13IMP biosynthetic process (GO:0006188)4.21705117
14* DNA double-strand break processing (GO:0000729)4.20587949
15regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)4.18989363
16protein localization to chromosome, centromeric region (GO:0071459)4.17559108
17CENP-A containing nucleosome assembly (GO:0034080)4.17455088
18nucleobase biosynthetic process (GO:0046112)4.15654117
19chromatin remodeling at centromere (GO:0031055)4.15219280
20* telomere maintenance via telomere lengthening (GO:0010833)4.10119985
21nuclear pore complex assembly (GO:0051292)4.07190422
22kinetochore organization (GO:0051383)4.06487885
23nucleotide-excision repair, DNA gap filling (GO:0006297)4.01107211
24double-strand break repair via nonhomologous end joining (GO:0006303)3.98425794
25non-recombinational repair (GO:0000726)3.98425794
26DNA replication-dependent nucleosome organization (GO:0034723)3.97190579
27DNA replication-dependent nucleosome assembly (GO:0006335)3.97190579
28establishment of integrated proviral latency (GO:0075713)3.97185827
29mitotic metaphase plate congression (GO:0007080)3.96025316
30DNA ligation (GO:0006266)3.87751634
31folic acid-containing compound biosynthetic process (GO:0009396)3.87535159
32mitotic spindle checkpoint (GO:0071174)3.87504233
33DNA replication-independent nucleosome assembly (GO:0006336)3.82900585
34DNA replication-independent nucleosome organization (GO:0034724)3.82900585
35purine nucleobase biosynthetic process (GO:0009113)3.82604052
36mitotic nuclear envelope disassembly (GO:0007077)3.82159693
37regulation of nuclear cell cycle DNA replication (GO:0033262)3.76986146
38negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.75183784
39microtubule depolymerization (GO:0007019)3.73257272
40regulation of mitotic spindle checkpoint (GO:1903504)3.71251741
41regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.71251741
42kinetochore assembly (GO:0051382)3.71163123
43mitotic sister chromatid segregation (GO:0000070)3.67415689
44IMP metabolic process (GO:0046040)3.66408132
45mitotic chromosome condensation (GO:0007076)3.63846548
46* DNA duplex unwinding (GO:0032508)3.59022389
47* DNA geometric change (GO:0032392)3.58876655
48regulation of sister chromatid segregation (GO:0033045)3.58102285
49regulation of mitotic sister chromatid separation (GO:0010965)3.58102285
50regulation of mitotic sister chromatid segregation (GO:0033047)3.58102285
51metaphase plate congression (GO:0051310)3.56391496
52attachment of spindle microtubules to kinetochore (GO:0008608)3.56191580
53mitotic spindle assembly checkpoint (GO:0007094)3.53134611
54heterochromatin organization (GO:0070828)3.52006234
55membrane disassembly (GO:0030397)3.50229857
56nuclear envelope disassembly (GO:0051081)3.50229857
57maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.49535881
58synapsis (GO:0007129)3.42730167
59DNA deamination (GO:0045006)3.41124950
60translesion synthesis (GO:0019985)3.40136407
61sister chromatid segregation (GO:0000819)3.39452306
62mitotic G2/M transition checkpoint (GO:0044818)3.38695689
63histone exchange (GO:0043486)3.38609786
64regulation of double-strand break repair via homologous recombination (GO:0010569)3.38271994
65* telomere maintenance (GO:0000723)3.35512913
66meiotic chromosome segregation (GO:0045132)3.34506558
67formation of translation preinitiation complex (GO:0001731)3.33796655
68* telomere organization (GO:0032200)3.33599101
69mismatch repair (GO:0006298)3.32431838
70regulation of sister chromatid cohesion (GO:0007063)3.31323438
71establishment of chromosome localization (GO:0051303)3.28703671
72somatic hypermutation of immunoglobulin genes (GO:0016446)3.28688455
73somatic diversification of immune receptors via somatic mutation (GO:0002566)3.28688455
74pore complex assembly (GO:0046931)3.21651230
75chromosome condensation (GO:0030261)3.21609753
76negative regulation of mRNA processing (GO:0050686)3.20834627
77ribosomal small subunit assembly (GO:0000028)3.19797358
78regulation of centrosome duplication (GO:0010824)3.19691733
79DNA strand renaturation (GO:0000733)3.19629919
80DNA synthesis involved in DNA repair (GO:0000731)3.18738242
81chromatin assembly or disassembly (GO:0006333)3.17450763
82negative regulation of DNA recombination (GO:0045910)3.14238082
83protein K6-linked ubiquitination (GO:0085020)3.13424476
84* DNA catabolic process, exonucleolytic (GO:0000738)3.13030064
85* DNA replication (GO:0006260)3.06447573
86ribosome assembly (GO:0042255)3.05999443
87positive regulation of chromosome segregation (GO:0051984)3.04989254
88ribosome biogenesis (GO:0042254)3.04604142
89* DNA conformation change (GO:0071103)3.04189770
90mitotic sister chromatid cohesion (GO:0007064)3.04000518
91maturation of SSU-rRNA (GO:0030490)3.03696021
92negative regulation of DNA-dependent DNA replication (GO:2000104)3.03442570
93protein localization to chromosome (GO:0034502)3.03392237
94postreplication repair (GO:0006301)3.01709043
95replication fork processing (GO:0031297)3.01635128
96regulation of histone H3-K9 methylation (GO:0051570)3.00319412
97DNA topological change (GO:0006265)2.98465043
98regulation of spindle organization (GO:0090224)2.97103527
99chromosome segregation (GO:0007059)2.94373143
100negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.93913061
101deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.92637425
102* base-excision repair (GO:0006284)2.92286142
103regulation of helicase activity (GO:0051095)2.91063671
104transcription-coupled nucleotide-excision repair (GO:0006283)2.90831860
105negative regulation of chromosome segregation (GO:0051985)2.90638659
106spindle checkpoint (GO:0031577)2.90405692
107ATP-dependent chromatin remodeling (GO:0043044)2.90273482
108regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.90192821
109regulation of mitotic metaphase/anaphase transition (GO:0030071)2.88556895
110regulation of centrosome cycle (GO:0046605)2.88378968
111ribosomal large subunit biogenesis (GO:0042273)2.88326065
112ribonucleoprotein complex biogenesis (GO:0022613)2.87807873
113intra-S DNA damage checkpoint (GO:0031573)2.87661314
114regulation of chromosome segregation (GO:0051983)2.87432606
115dosage compensation (GO:0007549)2.86215434
116negative regulation of sister chromatid segregation (GO:0033046)2.85716824
117negative regulation of mitotic sister chromatid separation (GO:2000816)2.85716824
118negative regulation of mitotic sister chromatid segregation (GO:0033048)2.85716824
119negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.85716824
120spindle assembly checkpoint (GO:0071173)2.84254692
121regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.82806253
122regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.82054384
123maturation of 5.8S rRNA (GO:0000460)2.81033846
124regulation of DNA-dependent DNA replication (GO:0090329)2.80449858
125rRNA processing (GO:0006364)2.80417397

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human4.58217622
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.29077062
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.78242221
4* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.40430495
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.25111799
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.77654448
7MYC_19079543_ChIP-ChIP_MESCs_Mouse2.63232282
8MYC_19030024_ChIP-ChIP_MESCs_Mouse2.62394100
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.48653274
10MYC_18358816_ChIP-ChIP_MESCs_Mouse2.48263240
11E2F1_21310950_ChIP-Seq_MCF-7_Human2.28844065
12GABP_17652178_ChIP-ChIP_JURKAT_Human2.25885232
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.23153928
14NELFA_20434984_ChIP-Seq_ESCs_Mouse2.21096976
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.16831497
16AR_21909140_ChIP-Seq_LNCAP_Human2.14495896
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.11860483
18EGR1_19374776_ChIP-ChIP_THP-1_Human2.11356340
19XRN2_22483619_ChIP-Seq_HELA_Human2.01697825
20MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.00857661
21HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.00113442
22E2F7_22180533_ChIP-Seq_HELA_Human11.1154909
23VDR_23849224_ChIP-Seq_CD4+_Human1.93909873
24ELF1_17652178_ChIP-ChIP_JURKAT_Human1.93529453
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.92454469
26MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.90711506
27KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.84893976
28FOXP3_21729870_ChIP-Seq_TREG_Human1.84630325
29MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.81130205
30SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.80354886
31MYCN_18555785_ChIP-Seq_MESCs_Mouse1.77017925
32E2F1_18555785_ChIP-Seq_MESCs_Mouse1.75335012
33DCP1A_22483619_ChIP-Seq_HELA_Human1.69585305
34NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.64672831
35PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.63330963
36POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.62536589
37TTF2_22483619_ChIP-Seq_HELA_Human1.60800173
38NANOG_18555785_ChIP-Seq_MESCs_Mouse1.60324922
39TP63_19390658_ChIP-ChIP_HaCaT_Human1.58710644
40* GABP_19822575_ChIP-Seq_HepG2_Human1.57380618
41MYC_22102868_ChIP-Seq_BL_Human1.55920096
42ELK1_19687146_ChIP-ChIP_HELA_Human1.54616821
43TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.52567424
44CIITA_25753668_ChIP-Seq_RAJI_Human1.51280512
45HOXB4_20404135_ChIP-ChIP_EML_Mouse1.51169564
46YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.45650980
47FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.45294787
48POU5F1_16153702_ChIP-ChIP_HESCs_Human1.45253151
49EWS_26573619_Chip-Seq_HEK293_Human1.44037299
50THAP11_20581084_ChIP-Seq_MESCs_Mouse1.42608345
51HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.41969602
52SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.36893394
53ZFX_18555785_ChIP-Seq_MESCs_Mouse1.36271028
54ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.36070669
55* KDM5A_27292631_Chip-Seq_BREAST_Human1.35706941
56SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.32426966
57E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.30871727
58YY1_21170310_ChIP-Seq_MESCs_Mouse1.30425288
59FUS_26573619_Chip-Seq_HEK293_Human1.28004273
60NANOG_16153702_ChIP-ChIP_HESCs_Human1.27989850
61ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.27950008
62SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.25844986
63SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.23985197
64ERG_20887958_ChIP-Seq_HPC-7_Mouse1.23248850
65FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.21204096
66SOX2_16153702_ChIP-ChIP_HESCs_Human1.21178896
67* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.20369750
68SRF_21415370_ChIP-Seq_HL-1_Mouse1.18213041
69PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.17230001
70POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.15450022
71VDR_21846776_ChIP-Seq_THP-1_Human1.13457653
72SOX2_18555785_ChIP-Seq_MESCs_Mouse1.13410126
73PADI4_21655091_ChIP-ChIP_MCF-7_Human1.12561917
74POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.10074837
75STAT3_1855785_ChIP-Seq_MESCs_Mouse1.09646890
76SPI1_23547873_ChIP-Seq_NB4_Human1.08758435
77CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.08653319
78KLF4_18555785_ChIP-Seq_MESCs_Mouse1.07158093
79TFEB_21752829_ChIP-Seq_HELA_Human1.07000336
80NOTCH1_21737748_ChIP-Seq_TLL_Human1.05660755
81CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.03131530
82HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.01101487
83HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.97583374
84* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.97054739
85SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.96349528
86ZNF274_21170338_ChIP-Seq_K562_Hela0.94738407
87KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.94213800
88VDR_22108803_ChIP-Seq_LS180_Human0.94170112
89DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.93994393
90ESR1_15608294_ChIP-ChIP_MCF-7_Human0.93847931
91FLI1_27457419_Chip-Seq_LIVER_Mouse0.93474732
92MYC_18940864_ChIP-ChIP_HL60_Human0.93467933
93CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.91637771
94IRF1_19129219_ChIP-ChIP_H3396_Human0.90788740
95GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90553038
96SCL_19346495_ChIP-Seq_HPC-7_Human0.89495121
97IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.89361326
98ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.88255533
99IGF1R_20145208_ChIP-Seq_DFB_Human0.87312494
100MYB_21317192_ChIP-Seq_ERMYB_Mouse0.85927606
101MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.84218544
102FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.83181011
103KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.81953936
104KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.81953936
105KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.81953936
106POU3F2_20337985_ChIP-ChIP_501MEL_Human0.81524580
107BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.80047103
108SOX17_20123909_ChIP-Seq_XEN_Mouse0.79289839
109CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.77901050
110RBPJ_22232070_ChIP-Seq_NCS_Mouse0.77832896
111SALL1_21062744_ChIP-ChIP_HESCs_Human0.77211104
112CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.76061343
113KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.75191824
114NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.75164235
115CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.74623211
116TCF3_18692474_ChIP-Seq_MEFs_Mouse0.73984887
117CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.73892631
118NANOG_21062744_ChIP-ChIP_HESCs_Human0.73692333
119HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.73663050
120NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.70566961
121PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.69399464
122GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.69054320
123CHD1_26751641_Chip-Seq_LNCaP_Human0.65587167
124PCGF2_27294783_Chip-Seq_ESCs_Mouse0.64365855
125NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.61840767

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability5.08457353
2MP0003693_abnormal_embryo_hatching4.88862318
3MP0008057_abnormal_DNA_replication4.75576512
4MP0003111_abnormal_nucleus_morphology4.70583980
5MP0003077_abnormal_cell_cycle3.93833151
6MP0004957_abnormal_blastocyst_morpholog3.81671017
7MP0008058_abnormal_DNA_repair3.45092110
8MP0008007_abnormal_cellular_replicative2.67761485
9MP0002396_abnormal_hematopoietic_system2.60035382
10MP0008932_abnormal_embryonic_tissue2.46455571
11MP0000350_abnormal_cell_proliferation2.14108996
12MP0008877_abnormal_DNA_methylation2.10596685
13MP0010352_gastrointestinal_tract_polyps2.08735207
14MP0010307_abnormal_tumor_latency2.06489097
15MP0001730_embryonic_growth_arrest2.05877705
16MP0000490_abnormal_crypts_of1.98416593
17MP0003123_paternal_imprinting1.78808131
18MP0005380_embryogenesis_phenotype1.65188583
19MP0001672_abnormal_embryogenesis/_devel1.65188583
20MP0003786_premature_aging1.61108199
21MP0004808_abnormal_hematopoietic_stem1.60459563
22MP0002019_abnormal_tumor_incidence1.51990481
23MP0000313_abnormal_cell_death1.50512959
24MP0001697_abnormal_embryo_size1.47657018
25MP0003984_embryonic_growth_retardation1.46482498
26MP0002088_abnormal_embryonic_growth/wei1.42884617
27MP0006292_abnormal_olfactory_placode1.40227391
28MP0005397_hematopoietic_system_phenotyp1.39194704
29MP0001545_abnormal_hematopoietic_system1.39194704
30MP0002080_prenatal_lethality1.38781261
31MP0003121_genomic_imprinting1.35847360
32MP0002085_abnormal_embryonic_tissue1.33494445
33MP0003890_abnormal_embryonic-extraembry1.31839188
34MP0003806_abnormal_nucleotide_metabolis1.31795974
35MP0002086_abnormal_extraembryonic_tissu1.30805218
36MP0002398_abnormal_bone_marrow1.30761935
37MP0005076_abnormal_cell_differentiation1.28917734
38MP0009333_abnormal_splenocyte_physiolog1.27525144
39MP0003718_maternal_effect1.27287488
40MP0002938_white_spotting1.26882251
41MP0003763_abnormal_thymus_physiology1.21492223
42MP0004197_abnormal_fetal_growth/weight/1.20968041
43MP0002722_abnormal_immune_system1.20947167
44MP0000689_abnormal_spleen_morphology1.20417782
45MP0003567_abnormal_fetal_cardiomyocyte1.19169265
46MP0000703_abnormal_thymus_morphology1.18988553
47MP0002084_abnormal_developmental_patter1.16886067
48MP0001293_anophthalmia1.15533044
49MP0002697_abnormal_eye_size1.14359326
50MP0003119_abnormal_digestive_system1.13680924
51MP0002234_abnormal_pharynx_morphology1.12723141
52MP0001835_abnormal_antigen_presentation1.09313163
53MP0005174_abnormal_tail_pigmentation1.09185849
54MP0006035_abnormal_mitochondrial_morpho1.08792329
55MP0002210_abnormal_sex_determination1.07659141
56MP0005075_abnormal_melanosome_morpholog1.06755434
57MP0001529_abnormal_vocalization1.06578424
58MP0001188_hyperpigmentation1.03989060
59MP0002429_abnormal_blood_cell1.03206900
60MP0008789_abnormal_olfactory_epithelium1.01464843
61MP0002132_abnormal_respiratory_system1.00924367
62MP0006072_abnormal_retinal_apoptosis0.99025756
63MP0001145_abnormal_male_reproductive0.95760371
64MP0009278_abnormal_bone_marrow0.95076871
65MP0003195_calcinosis0.94672140
66MP0000428_abnormal_craniofacial_morphol0.93400703
67MP0002092_abnormal_eye_morphology0.91919573
68MP0000716_abnormal_immune_system0.91303820
69MP0001800_abnormal_humoral_immune0.90512818
70MP0001346_abnormal_lacrimal_gland0.90063454
71MP0003186_abnormal_redox_activity0.89527688
72MP0003436_decreased_susceptibility_to0.86705072
73MP0000858_altered_metastatic_potential0.86306584
74MP0001119_abnormal_female_reproductive0.85592858
75MP0001177_atelectasis0.84950657
76MP0001915_intracranial_hemorrhage0.84700923
77MP0002751_abnormal_autonomic_nervous0.84433775
78MP0003136_yellow_coat_color0.84052752
79MP0004147_increased_porphyrin_level0.84024263
80MP0001929_abnormal_gametogenesis0.83857875
81MP0002452_abnormal_antigen_presenting0.83321478
82MP0000631_abnormal_neuroendocrine_gland0.83076445
83MP0002102_abnormal_ear_morphology0.82867273
84MP0002254_reproductive_system_inflammat0.82479832
85MP0004264_abnormal_extraembryonic_tissu0.81790644
86MP0002163_abnormal_gland_morphology0.81687746
87MP0002095_abnormal_skin_pigmentation0.80921473
88MP0009697_abnormal_copulation0.80790750
89MP0005671_abnormal_response_to0.80582505
90MP0002090_abnormal_vision0.80559706
91MP0001853_heart_inflammation0.80449533
92MP0002420_abnormal_adaptive_immunity0.80433645
93MP0002233_abnormal_nose_morphology0.80419164
94MP0001819_abnormal_immune_cell0.79954905
95MP0000653_abnormal_sex_gland0.79526949
96MP0006054_spinal_hemorrhage0.79411772
97MP0003861_abnormal_nervous_system0.79198044
98MP0009672_abnormal_birth_weight0.78476617
99MP0000566_synostosis0.77695206
100MP0005395_other_phenotype0.77170951
101MP0005384_cellular_phenotype0.75521653
102MP0002075_abnormal_coat/hair_pigmentati0.75127038
103MP0009053_abnormal_anal_canal0.74671127
104MP0003698_abnormal_male_reproductive0.74173810
105MP0002405_respiratory_system_inflammati0.73801311
106MP0003941_abnormal_skin_development0.73195731
107MP0005621_abnormal_cell_physiology0.71409794
108MP0002160_abnormal_reproductive_system0.71260123
109MP0010030_abnormal_orbit_morphology0.70957872
110MP0005391_vision/eye_phenotype0.70936321
111MP0005499_abnormal_olfactory_system0.70550167
112MP0005394_taste/olfaction_phenotype0.70550167
113MP0000049_abnormal_middle_ear0.69602340
114MP0002723_abnormal_immune_serum0.68150722
115MP0000685_abnormal_immune_system0.68075029
116MP0005025_abnormal_response_to0.68026459
117MP0003755_abnormal_palate_morphology0.67456819
118MP0003938_abnormal_ear_development0.66765210
119MP0000477_abnormal_intestine_morphology0.66610259
120MP0003315_abnormal_perineum_morphology0.66567902
121MP0003937_abnormal_limbs/digits/tail_de0.65962593
122MP0003699_abnormal_female_reproductive0.65859123
123MP0000358_abnormal_cell_content/0.65593568
124MP0010234_abnormal_vibrissa_follicle0.65197784
125MP0000371_diluted_coat_color0.64638295
126MP0005464_abnormal_platelet_physiology0.64488319
127MP0003656_abnormal_erythrocyte_physiolo0.64413156
128MP0009785_altered_susceptibility_to0.63506598
129MP0001186_pigmentation_phenotype0.63081817
130MP0005389_reproductive_system_phenotype0.62538525
131MP0009703_decreased_birth_body0.62329035
132MP0003221_abnormal_cardiomyocyte_apopto0.62223510
133MP0002161_abnormal_fertility/fecundity0.62166652
134MP0002111_abnormal_tail_morphology0.61965935
135MP0001286_abnormal_eye_development0.61932011
136MP0000537_abnormal_urethra_morphology0.61721794
137MP0000647_abnormal_sebaceous_gland0.61449959
138MP0001727_abnormal_embryo_implantation0.60828245
139MP0000432_abnormal_head_morphology0.60013718
140MP0008995_early_reproductive_senescence0.56793457
141MP0004133_heterotaxia0.56409841
142MP0003935_abnormal_craniofacial_develop0.56159950
143MP0001299_abnormal_eye_distance/0.54455958
144MP0003787_abnormal_imprinting0.54404079
145MP0005501_abnormal_skin_physiology0.53950383

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)5.92247033
2Chromosomal breakage induced by crosslinking agents (HP:0003221)5.86394187
3Birth length less than 3rd percentile (HP:0003561)4.86727318
4Reticulocytopenia (HP:0001896)4.33295180
5Abnormality of chromosome stability (HP:0003220)4.30935938
6Meckel diverticulum (HP:0002245)3.93659925
7Abnormality of the preputium (HP:0100587)3.84049800
8Aplasia/Hypoplasia of the uvula (HP:0010293)3.83815139
9Abnormality of the ileum (HP:0001549)3.78025806
10Breast hypoplasia (HP:0003187)3.54339238
11Duplicated collecting system (HP:0000081)3.37040669
12Medulloblastoma (HP:0002885)3.24586677
13Agnosia (HP:0010524)3.23708233
14Myelodysplasia (HP:0002863)3.23530897
15Patellar aplasia (HP:0006443)3.18561893
16Small intestinal stenosis (HP:0012848)3.16605045
17Duodenal stenosis (HP:0100867)3.16605045
18Abnormality of pyrimidine metabolism (HP:0004353)3.12579919
19Selective tooth agenesis (HP:0001592)3.03175175
20Oral leukoplakia (HP:0002745)3.00813414
21Aplasia/Hypoplasia of the patella (HP:0006498)2.96232299
22Abnormality of the renal collecting system (HP:0004742)2.95978904
23Bone marrow hypocellularity (HP:0005528)2.95939492
24Ependymoma (HP:0002888)2.95871720
25Absent thumb (HP:0009777)2.92149408
26Abnormal number of incisors (HP:0011064)2.87860260
27Clubbing of toes (HP:0100760)2.87858319
28Aplastic anemia (HP:0001915)2.83983688
29Absent radius (HP:0003974)2.83938982
30Impulsivity (HP:0100710)2.82678278
31Abnormality of cells of the erythroid lineage (HP:0012130)2.80282031
32Abnormal number of erythroid precursors (HP:0012131)2.79460681
33Abnormality of the carotid arteries (HP:0005344)2.74606303
34Colon cancer (HP:0003003)2.72686341
35Abnormality of the duodenum (HP:0002246)2.68356604
36Cortical dysplasia (HP:0002539)2.66189257
37Rhabdomyosarcoma (HP:0002859)2.65761615
38Aplasia involving forearm bones (HP:0009822)2.62157156
39Absent forearm bone (HP:0003953)2.62157156
40Abnormality of the anterior horn cell (HP:0006802)2.53737854
41Degeneration of anterior horn cells (HP:0002398)2.53737854
42* Ectopic kidney (HP:0000086)2.52258233
43Abnormality of DNA repair (HP:0003254)2.51677141
44Tracheoesophageal fistula (HP:0002575)2.50388837
45Sloping forehead (HP:0000340)2.49697603
46Aplasia/Hypoplasia of the sternum (HP:0006714)2.46505114
47IgM deficiency (HP:0002850)2.45883722
48Triphalangeal thumb (HP:0001199)2.45738182
49Pancreatic islet-cell hyperplasia (HP:0004510)2.35745186
50Embryonal neoplasm (HP:0002898)2.30766884
51Multiple enchondromatosis (HP:0005701)2.28993000
52Premature graying of hair (HP:0002216)2.26585810
53Lymphoma (HP:0002665)2.21026887
54Horseshoe kidney (HP:0000085)2.20823902
55Neoplasm of the adrenal cortex (HP:0100641)2.20438832
56Short thumb (HP:0009778)2.20333470
57Pallor (HP:0000980)2.19219461
58Prominent metopic ridge (HP:0005487)2.19167170
59Biliary tract neoplasm (HP:0100574)2.19002356
60Abnormal lung lobation (HP:0002101)2.16463385
61Prominent nose (HP:0000448)2.16329011
62Abnormality of cochlea (HP:0000375)2.14485489
63Rough bone trabeculation (HP:0100670)2.14369509
64Increased nuchal translucency (HP:0010880)2.13432116
65Carpal bone hypoplasia (HP:0001498)2.13411126
66High pitched voice (HP:0001620)2.13193694
67Cafe-au-lait spot (HP:0000957)2.12630191
68Amaurosis fugax (HP:0100576)2.12189010
6911 pairs of ribs (HP:0000878)2.11641702
70Neoplasm of the adrenal gland (HP:0100631)2.09446555
71Neoplasm of the pancreas (HP:0002894)2.09386640
72Macrocytic anemia (HP:0001972)2.05907652
73Abnormality of reticulocytes (HP:0004312)2.05496990
74Breast carcinoma (HP:0003002)2.05376634
75Supernumerary spleens (HP:0009799)2.03966458
76Cellular immunodeficiency (HP:0005374)2.03817416
77Abnormality of the metopic suture (HP:0005556)2.02677785
78Nephroblastoma (Wilms tumor) (HP:0002667)2.01411083
79Abnormality of the labia minora (HP:0012880)1.99721946
80Basal cell carcinoma (HP:0002671)1.99593817
81Choanal atresia (HP:0000453)1.99476058
82Ovarian neoplasm (HP:0100615)1.98451649
83Microretrognathia (HP:0000308)1.97317258
84Leukopenia (HP:0001882)1.96519174
85Volvulus (HP:0002580)1.96366375
86Pancytopenia (HP:0001876)1.96345207
87Acute lymphatic leukemia (HP:0006721)1.94882639
88Malignant gastrointestinal tract tumors (HP:0006749)1.92983235
89Gastrointestinal carcinoma (HP:0002672)1.92983235
90Neoplasm of striated muscle (HP:0009728)1.92428594
91Thrombocytosis (HP:0001894)1.92413664
92Squamous cell carcinoma (HP:0002860)1.87289756
93Septo-optic dysplasia (HP:0100842)1.85613594
94Glioma (HP:0009733)1.85238276
95Uterine neoplasm (HP:0010784)1.84950672
96Neoplasm of the small intestine (HP:0100833)1.84281413
97Proximal placement of thumb (HP:0009623)1.83898471
98Embryonal renal neoplasm (HP:0011794)1.83418791
99High anterior hairline (HP:0009890)1.82725576
100Abnormality of methionine metabolism (HP:0010901)1.82516261
101Atresia of the external auditory canal (HP:0000413)1.82332082
102Hypoplasia of the capital femoral epiphysis (HP:0003090)1.81426981
103Hyperinsulinemic hypoglycemia (HP:0000825)1.79783483
104Cleft eyelid (HP:0000625)1.79622791
105Arteriovenous malformation (HP:0100026)1.78446868
106Neoplasm of the oral cavity (HP:0100649)1.77375289
107Ureteral duplication (HP:0000073)1.75066170
108Reduced antithrombin III activity (HP:0001976)1.74204154
109Abnormality of the septum pellucidum (HP:0007375)1.73825455
110Aplasia/Hypoplasia of the sacrum (HP:0008517)1.73365193
111Acute myeloid leukemia (HP:0004808)1.72678114
112Slender long bone (HP:0003100)1.72245700
113Neoplasm of the colon (HP:0100273)1.72050113
114Deviation of the thumb (HP:0009603)1.71330169
115Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.70024411
116Type I transferrin isoform profile (HP:0003642)1.69822459
117Small hand (HP:0200055)1.69636860
118Abnormality of abdominal situs (HP:0011620)1.69090746
119Abdominal situs inversus (HP:0003363)1.69090746
120Astrocytoma (HP:0009592)1.68474791
121Abnormality of the astrocytes (HP:0100707)1.68474791
122Abnormality of chromosome segregation (HP:0002916)1.66005047
123Intestinal polyposis (HP:0200008)1.65679560
124Microvesicular hepatic steatosis (HP:0001414)1.64088568
125Progressive external ophthalmoplegia (HP:0000590)1.62269907
126Irregular epiphyses (HP:0010582)1.61632796
127Aqueductal stenosis (HP:0002410)1.60679687
128Hypochromic anemia (HP:0001931)1.59978408
129Megaloblastic anemia (HP:0001889)1.59810137
130Asplenia (HP:0001746)1.59338744
131Abnormality of the fingertips (HP:0001211)1.58607317
132Morphological abnormality of the inner ear (HP:0011390)1.58368689
133Recurrent abscess formation (HP:0002722)1.58280233
134Abnormality of the prostate (HP:0008775)1.57605477
135Facial asymmetry (HP:0000324)1.56594151
136Limb hypertonia (HP:0002509)1.55298314
137Bilateral microphthalmos (HP:0007633)1.54771853
138Meningioma (HP:0002858)1.53326517
139Leiomyosarcoma (HP:0100243)1.52971283
140Uterine leiomyosarcoma (HP:0002891)1.52971283
141Intestinal polyp (HP:0005266)1.51786721
142Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.50806719

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC75.04120272
2WEE14.19381256
3BUB13.52979479
4EIF2AK12.98969858
5SRPK12.78170468
6NEK22.77422751
7TTK2.61459913
8PLK42.59059713
9TNIK2.49957763
10ACVR1B2.25518305
11CDK122.19296043
12PLK12.07885921
13ATR2.07540905
14BRSK22.06465485
15TRIM281.95226153
16TAF11.86191003
17ZAK1.79001883
18CDK71.78772788
19VRK11.76620989
20VRK21.76054344
21MKNK11.73758438
22STK161.72030869
23TLK11.68661726
24ERBB31.68592929
25NUAK11.65304071
26AURKB1.63790810
27TSSK61.63105407
28PNCK1.61183195
29DYRK31.56291538
30CDK41.53400324
31CHEK21.49607971
32EIF2AK31.47162831
33NEK11.46659860
34STK101.44734499
35IRAK41.43732530
36BMPR1B1.41104674
37RPS6KB21.40225055
38TESK21.39646235
39PASK1.37801850
40BRD41.37143344
41STK41.37077605
42NME21.35089870
43MKNK21.34281241
44MST41.33870078
45PLK31.30935411
46MAP3K81.27344782
47CHEK11.26559439
48IRAK31.24036089
49MAP4K11.22258162
50MAP3K101.21551070
51CCNB11.21066886
52PLK21.15765204
53LATS11.12434078
54RPS6KA41.11567134
55BRSK11.11434339
56PIM11.08968627
57AURKA1.08500741
58WNK31.05481572
59ATM1.04415095
60CLK11.01687152
61EEF2K0.98528079
62FLT30.97557599
63SCYL20.96376697
64TGFBR10.92201954
65FRK0.91722127
66SMG10.90037029
67CDK60.88987192
68CDK20.88893633
69PAK40.83868989
70BTK0.79167782
71EIF2AK20.78541120
72MAP2K30.76589060
73TEC0.76133404
74NEK90.73382433
75EPHA20.72565990
76CSF1R0.70850401
77NLK0.70820929
78STK30.70574700
79BLK0.70249999
80CDK80.68860469
81YES10.67331928
82BRAF0.66819821
83CDK10.65321582
84CAMK1G0.64130438
85BCR0.63485081
86FGFR10.62351385
87CSNK2A10.61288801
88ALK0.60310483
89MELK0.59666403
90CSNK2A20.57780417
91NME10.55679559
92FGFR20.55203210
93MAP3K40.54583475
94KIT0.54515565
95PKN20.50021351
96TAOK20.48156129
97EPHA40.47184736
98CSNK1G10.46651655
99JAK30.42096493
100CSNK1E0.41575088
101CAMK1D0.41007901
102DYRK20.40323246
103GRK60.40295244
104TYK20.39818631
105PIM20.39673787
106CDK30.39435541
107AKT20.39154826
108RPS6KA50.38175742
109LYN0.37733273
110STK38L0.36846970
111PBK0.36792528
112PAK10.35618148
113LRRK20.34982260
114PRKDC0.34516678
115ERBB40.33675135
116CDK90.33221648
117MAPK110.33200917
118BCKDK0.32054704
119MAP4K20.31513302
120MAP3K110.31477418
121KDR0.30651622
122CSNK1G30.30120162
123ZAP700.30039127
124MAPKAPK50.29509235
125MAPK140.29361617
126STK240.28927899
127AKT10.28796759
128CSNK1G20.27680952
129MATK0.27241012
130MAP3K50.26841082
131IKBKB0.26355243
132PRKCI0.24130263
133TESK10.24024256
134MTOR0.23872956
135GRK10.22493876
136GSK3B0.21620157
137CSNK1A1L0.21078085
138DAPK10.19347362
139AKT30.19096393

Predicted pathways (KEGG)

RankGene SetZ-score
1* DNA replication_Homo sapiens_hsa030305.58586594
2Mismatch repair_Homo sapiens_hsa034304.68222429
3Homologous recombination_Homo sapiens_hsa034403.56943003
4Base excision repair_Homo sapiens_hsa034103.37885212
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.16502215
6One carbon pool by folate_Homo sapiens_hsa006703.03778385
7Spliceosome_Homo sapiens_hsa030403.03697709
8Fanconi anemia pathway_Homo sapiens_hsa034602.97179099
9Cell cycle_Homo sapiens_hsa041102.89526656
10Nucleotide excision repair_Homo sapiens_hsa034202.87220862
11RNA transport_Homo sapiens_hsa030132.71542961
12RNA polymerase_Homo sapiens_hsa030202.64337177
13Ribosome_Homo sapiens_hsa030102.49977996
14Pyrimidine metabolism_Homo sapiens_hsa002402.43083829
15Non-homologous end-joining_Homo sapiens_hsa034502.33299923
16Proteasome_Homo sapiens_hsa030502.10564915
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.10466288
18RNA degradation_Homo sapiens_hsa030181.78182635
19Basal transcription factors_Homo sapiens_hsa030221.71586196
20p53 signaling pathway_Homo sapiens_hsa041151.69189363
21mRNA surveillance pathway_Homo sapiens_hsa030151.62409049
22Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.46109898
23Systemic lupus erythematosus_Homo sapiens_hsa053221.39353945
24Propanoate metabolism_Homo sapiens_hsa006401.35559213
25Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.33307775
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.23456753
27Purine metabolism_Homo sapiens_hsa002301.21236802
28Herpes simplex infection_Homo sapiens_hsa051681.17487617
29Pyruvate metabolism_Homo sapiens_hsa006201.16876122
302-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.12656363
31Fatty acid elongation_Homo sapiens_hsa000621.10687971
32Epstein-Barr virus infection_Homo sapiens_hsa051691.10611809
33Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.08181015
34Steroid biosynthesis_Homo sapiens_hsa001001.06443001
35Drug metabolism - other enzymes_Homo sapiens_hsa009831.05576118
36Viral carcinogenesis_Homo sapiens_hsa052030.95909222
37Pentose phosphate pathway_Homo sapiens_hsa000300.88459778
38Selenocompound metabolism_Homo sapiens_hsa004500.86430670
39Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.85438202
40Folate biosynthesis_Homo sapiens_hsa007900.85375042
41Antigen processing and presentation_Homo sapiens_hsa046120.85227733
42Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.82828818
43Cysteine and methionine metabolism_Homo sapiens_hsa002700.80860366
44Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.80529431
45Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.77519332
46Biosynthesis of amino acids_Homo sapiens_hsa012300.75525339
47HTLV-I infection_Homo sapiens_hsa051660.73397156
48Cyanoamino acid metabolism_Homo sapiens_hsa004600.72630361
49Transcriptional misregulation in cancer_Homo sapiens_hsa052020.71685867
50NF-kappa B signaling pathway_Homo sapiens_hsa040640.70590647
51Primary immunodeficiency_Homo sapiens_hsa053400.66838795
52Vitamin B6 metabolism_Homo sapiens_hsa007500.66587670
53Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.66449269
54Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.65429155
55Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.64001749
56Legionellosis_Homo sapiens_hsa051340.61620820
57Oocyte meiosis_Homo sapiens_hsa041140.61528697
58Measles_Homo sapiens_hsa051620.60543518
59MicroRNAs in cancer_Homo sapiens_hsa052060.58410827
60Apoptosis_Homo sapiens_hsa042100.52354094
61Small cell lung cancer_Homo sapiens_hsa052220.51513904
62Glutathione metabolism_Homo sapiens_hsa004800.50396992
63Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.49877909
64Huntingtons disease_Homo sapiens_hsa050160.49108363
65Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.48482086
66Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.48345419
67Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.47877563
68Wnt signaling pathway_Homo sapiens_hsa043100.47708694
69Sulfur relay system_Homo sapiens_hsa041220.46757931
70Hepatitis B_Homo sapiens_hsa051610.45443066
71Parkinsons disease_Homo sapiens_hsa050120.44636302
72Lysine degradation_Homo sapiens_hsa003100.44596373
73Intestinal immune network for IgA production_Homo sapiens_hsa046720.44527047
74Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.43536269
75Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.43059885
76Leishmaniasis_Homo sapiens_hsa051400.42545558
77Adherens junction_Homo sapiens_hsa045200.42394134
78RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.41365465
79Hedgehog signaling pathway_Homo sapiens_hsa043400.40596885
80Influenza A_Homo sapiens_hsa051640.38116926
81Thyroid cancer_Homo sapiens_hsa052160.37779912
82NOD-like receptor signaling pathway_Homo sapiens_hsa046210.37545205
83Hematopoietic cell lineage_Homo sapiens_hsa046400.36848344
84Oxidative phosphorylation_Homo sapiens_hsa001900.34977443
85Carbon metabolism_Homo sapiens_hsa012000.32793935
86Alcoholism_Homo sapiens_hsa050340.31862776
87Notch signaling pathway_Homo sapiens_hsa043300.31223612
88Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.31124233
89Fatty acid metabolism_Homo sapiens_hsa012120.31015192
90Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.29979381
91Pentose and glucuronate interconversions_Homo sapiens_hsa000400.29703426
92N-Glycan biosynthesis_Homo sapiens_hsa005100.29647604
93Basal cell carcinoma_Homo sapiens_hsa052170.29437986
94Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.29348062
95Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.29196396
96Colorectal cancer_Homo sapiens_hsa052100.27249379
97Galactose metabolism_Homo sapiens_hsa000520.25906938
98Chronic myeloid leukemia_Homo sapiens_hsa052200.25725285
99Fructose and mannose metabolism_Homo sapiens_hsa000510.24942030
100Shigellosis_Homo sapiens_hsa051310.24535834
101Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.24321433
102Central carbon metabolism in cancer_Homo sapiens_hsa052300.24182253
103Acute myeloid leukemia_Homo sapiens_hsa052210.23602965
104TGF-beta signaling pathway_Homo sapiens_hsa043500.20789301
105Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.20340511
106Vitamin digestion and absorption_Homo sapiens_hsa049770.20285833
107Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.19600363
108Tight junction_Homo sapiens_hsa045300.19151061
109Arachidonic acid metabolism_Homo sapiens_hsa005900.17985312
110Other glycan degradation_Homo sapiens_hsa005110.17391382
111Pathways in cancer_Homo sapiens_hsa052000.17087540
112Metabolic pathways_Homo sapiens_hsa011000.16960433
113Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.14870924
114Bladder cancer_Homo sapiens_hsa052190.14485023
115Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.14443159
116HIF-1 signaling pathway_Homo sapiens_hsa040660.13429828
117Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.13417210
118Viral myocarditis_Homo sapiens_hsa054160.13389165
119Arginine and proline metabolism_Homo sapiens_hsa003300.13210757
120Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.12922598
121Regulation of autophagy_Homo sapiens_hsa041400.12785943
122Melanoma_Homo sapiens_hsa052180.12571378
123Jak-STAT signaling pathway_Homo sapiens_hsa046300.12516810
124Renin-angiotensin system_Homo sapiens_hsa046140.12438236
125B cell receptor signaling pathway_Homo sapiens_hsa046620.12253687
126Butanoate metabolism_Homo sapiens_hsa006500.12219050
127Arginine biosynthesis_Homo sapiens_hsa002200.11788233
128Pancreatic cancer_Homo sapiens_hsa052120.11653508
129Protein export_Homo sapiens_hsa030600.11606248
130Hippo signaling pathway_Homo sapiens_hsa043900.11420574
131Asthma_Homo sapiens_hsa053100.10644667
132Peroxisome_Homo sapiens_hsa041460.10340262
133Prostate cancer_Homo sapiens_hsa052150.10038768
134Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.09019216
135Tryptophan metabolism_Homo sapiens_hsa003800.06781583
136Phototransduction_Homo sapiens_hsa047440.05993493
137Maturity onset diabetes of the young_Homo sapiens_hsa049500.05373963
138Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.05115273
139Fatty acid degradation_Homo sapiens_hsa000710.05104791
140Caffeine metabolism_Homo sapiens_hsa002320.04504957

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