DNAAF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is cilium-specific and is required for the stability of the ciliary architecture. It is involved in the regulation of microtubule-based cilia and actin-based brush border microvilli. Mutations in this gene are associated with primary ciliary dyskinesia-13. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1plasma membrane fusion (GO:0045026)9.93054251
2spermatid development (GO:0007286)9.73901325
3* axonemal dynein complex assembly (GO:0070286)9.61277387
4piRNA metabolic process (GO:0034587)9.51567705
5* epithelial cilium movement (GO:0003351)9.30363414
6reproduction (GO:0000003)8.97366346
7male meiosis (GO:0007140)8.30955081
8* cilium movement (GO:0003341)8.11497634
9synaptonemal complex organization (GO:0070193)8.02685124
10synaptonemal complex assembly (GO:0007130)7.66344375
11single fertilization (GO:0007338)7.43811465
12left/right axis specification (GO:0070986)7.38851556
13sperm capacitation (GO:0048240)7.30343173
14negative regulation of inclusion body assembly (GO:0090084)6.88402763
15* motile cilium assembly (GO:0044458)6.87167931
16microtubule bundle formation (GO:0001578)6.48168549
17spermatogenesis (GO:0007283)6.42490374
18male gamete generation (GO:0048232)6.40322347
19* regulation of cilium movement (GO:0003352)6.40292627
20fertilization (GO:0009566)6.39823373
21microtubule depolymerization (GO:0007019)6.25485812
22male meiosis I (GO:0007141)6.23880654
23DNA methylation involved in gamete generation (GO:0043046)5.96271110
24gamete generation (GO:0007276)5.88867802
25organic cation transport (GO:0015695)5.85430278
26primary alcohol catabolic process (GO:0034310)5.82134827
27* left/right pattern formation (GO:0060972)5.80641984
28regulation of inclusion body assembly (GO:0090083)5.67542913
29ventricular system development (GO:0021591)5.65692219
30vitamin transmembrane transport (GO:0035461)5.65327345
31germ cell development (GO:0007281)5.54232831
32cellular process involved in reproduction in multicellular organism (GO:0022412)5.42909163
33chromosome organization involved in meiosis (GO:0070192)5.41056006
34* epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.17667859
35meiosis I (GO:0007127)5.14684144
36meiotic nuclear division (GO:0007126)5.14253613
37response to xenobiotic stimulus (GO:0009410)5.12063031
38calcium ion-dependent exocytosis (GO:0017156)5.07229488
39seminiferous tubule development (GO:0072520)4.94092982
40diterpenoid biosynthetic process (GO:0016102)4.89520771
41microtubule severing (GO:0051013)4.87692570
42ethanol metabolic process (GO:0006067)4.78514904
43cell recognition (GO:0008037)4.78393483
44multicellular organismal reproductive process (GO:0048609)4.63617335
45negative regulation of T cell differentiation in thymus (GO:0033085)4.59240165
46tolerance induction (GO:0002507)4.57263212
47meiotic cell cycle (GO:0051321)4.53274370
48pyrimidine-containing compound transmembrane transport (GO:0072531)4.46490211
49* cell projection assembly (GO:0030031)4.25816635
50* cilium morphogenesis (GO:0060271)4.19528827
51chromosome condensation (GO:0030261)4.12948345
52regulation of germinal center formation (GO:0002634)4.09241851
53lung epithelium development (GO:0060428)4.09043205
54lateral ventricle development (GO:0021670)4.08647691
55protein localization to cilium (GO:0061512)4.06890767
56spermatid nucleus differentiation (GO:0007289)4.05157908
57DNA packaging (GO:0006323)4.02414484
58retinal rod cell development (GO:0046548)4.01193433
59one-carbon compound transport (GO:0019755)3.97847554
60chaperone-mediated protein complex assembly (GO:0051131)3.96065079
61glycerol ether metabolic process (GO:0006662)3.94671371
62protein polyglutamylation (GO:0018095)3.94002592
63regulation of interleukin-5 production (GO:0032674)3.91361362
64genitalia morphogenesis (GO:0035112)3.83092248
65monoubiquitinated protein deubiquitination (GO:0035520)3.81343014
66exogenous drug catabolic process (GO:0042738)3.70173533
67multicellular organismal development (GO:0007275)3.68860439
68retinal cone cell development (GO:0046549)3.67161296
69ether metabolic process (GO:0018904)3.64272407
70retinoic acid metabolic process (GO:0042573)3.60727328
71gene silencing by RNA (GO:0031047)3.58247526
72regulation of spindle checkpoint (GO:0090231)3.58178345
73negative regulation of B cell mediated immunity (GO:0002713)3.56090443
74negative regulation of immunoglobulin mediated immune response (GO:0002890)3.56090443
75terpenoid biosynthetic process (GO:0016114)3.51631298
76intraciliary transport (GO:0042073)3.51428324
77* regulation of microtubule-based movement (GO:0060632)3.50982811
78axoneme assembly (GO:0035082)3.49716283
79protein refolding (GO:0042026)3.46915549
80positive regulation of tolerance induction (GO:0002645)3.45156070
81meiotic cell cycle process (GO:1903046)3.44055992
82glomerular epithelial cell development (GO:0072310)3.39188883
83nucleoside diphosphate phosphorylation (GO:0006165)3.37476079
84ethanol oxidation (GO:0006069)3.34464887
85cytoplasmic microtubule organization (GO:0031122)3.32318723
86synapsis (GO:0007129)3.30265277
87single strand break repair (GO:0000012)3.30110498
88negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.29931206
89establishment of apical/basal cell polarity (GO:0035089)3.29744572
90negative regulation of humoral immune response (GO:0002921)3.26855171
91smoothened signaling pathway (GO:0007224)3.26205545
92hydrogen peroxide biosynthetic process (GO:0050665)3.23589609
93microtubule polymerization or depolymerization (GO:0031109)3.22940873
94photoreceptor cell maintenance (GO:0045494)3.20470505
95establishment or maintenance of monopolar cell polarity (GO:0061339)3.15970215
96establishment of monopolar cell polarity (GO:0061162)3.15970215
97carnitine transport (GO:0015879)3.14411489
98amino-acid betaine transport (GO:0015838)3.14411489
99mitotic sister chromatid cohesion (GO:0007064)3.12063318
100* microtubule-based movement (GO:0007018)3.11986873
101negative regulation of organelle assembly (GO:1902116)3.09471119
102nucleus organization (GO:0006997)3.09311259
103regulation of interleukin-13 production (GO:0032656)3.09159508
104regulation of meiosis I (GO:0060631)3.08933138
105GTP biosynthetic process (GO:0006183)3.06325957
106carnitine transmembrane transport (GO:1902603)3.04775151
107nonmotile primary cilium assembly (GO:0035058)3.04307549
108drug catabolic process (GO:0042737)3.01699792
109interferon-gamma secretion (GO:0072643)3.01113749
110alditol metabolic process (GO:0019400)3.00642337
111establishment of planar polarity (GO:0001736)2.99832552
112establishment of tissue polarity (GO:0007164)2.99832552
113glutathione derivative metabolic process (GO:1901685)2.98978064
114glutathione derivative biosynthetic process (GO:1901687)2.98978064
115regulation of centriole replication (GO:0046599)2.98583325
116polyol catabolic process (GO:0046174)2.96635663
117* cilium organization (GO:0044782)2.96033120
118lateral sprouting from an epithelium (GO:0060601)2.92833580
119centriole assembly (GO:0098534)2.92775747
120* determination of left/right symmetry (GO:0007368)2.85412410
121reactive oxygen species biosynthetic process (GO:1903409)2.85248028
122nuclear pore complex assembly (GO:0051292)2.84963506
123O-glycan processing (GO:0016266)2.81405359
124retinol metabolic process (GO:0042572)2.81233270
125* cilium assembly (GO:0042384)2.80530151
126aldehyde catabolic process (GO:0046185)2.79311468
127protein K11-linked deubiquitination (GO:0035871)2.77460290
128gene silencing (GO:0016458)2.75557052
129RNA localization (GO:0006403)2.74797530
130UTP biosynthetic process (GO:0006228)2.74063783
131glycolytic process (GO:0006096)2.73873164
132peptidyl-glutamic acid modification (GO:0018200)2.71273758
133primary alcohol metabolic process (GO:0034308)2.70426226
134* cellular component assembly involved in morphogenesis (GO:0010927)2.70337329
135* determination of bilateral symmetry (GO:0009855)2.69442280
136centriole replication (GO:0007099)2.68536938
137* microtubule-based process (GO:0007017)2.66330442
138cornea development in camera-type eye (GO:0061303)2.64094941
139* specification of symmetry (GO:0009799)2.61537519
140sexual reproduction (GO:0019953)2.60260498
141lactate metabolic process (GO:0006089)2.55856327
142RNA destabilization (GO:0050779)2.55475423
143regulation of tolerance induction (GO:0002643)2.53726542
144* organelle assembly (GO:0070925)2.52932184
145histone exchange (GO:0043486)2.52035294
146sex differentiation (GO:0007548)2.51014238
147regulation of autophagic vacuole assembly (GO:2000785)2.50834236
148regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.50002622
149positive regulation of smoothened signaling pathway (GO:0045880)2.48784481
150phosphatidylcholine biosynthetic process (GO:0006656)2.40553215
151intra-S DNA damage checkpoint (GO:0031573)2.38710306
152regulation of interleukin-6 biosynthetic process (GO:0045408)2.38033913
153benzene-containing compound metabolic process (GO:0042537)2.36813859
154excretion (GO:0007588)2.34775019
155regulation of collateral sprouting (GO:0048670)2.30992327
156rRNA catabolic process (GO:0016075)2.30579217
157apical protein localization (GO:0045176)2.29703656
158neurotransmitter metabolic process (GO:0042133)2.28968561
159protein O-linked glycosylation (GO:0006493)2.25239077
160phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.24732177
161spinal cord motor neuron differentiation (GO:0021522)2.24461566
162sialylation (GO:0097503)2.20596824
163regulation of cilium assembly (GO:1902017)2.19640905
164sperm motility (GO:0030317)13.2655019
165cilium or flagellum-dependent cell motility (GO:0001539)13.0873688
166fusion of sperm to egg plasma membrane (GO:0007342)13.0822164
167acrosome reaction (GO:0007340)11.5171237
168sperm-egg recognition (GO:0035036)11.2589626
169multicellular organism reproduction (GO:0032504)10.7939658
170acrosome assembly (GO:0001675)10.5015505
171cell wall macromolecule catabolic process (GO:0016998)10.3839383
172cell wall macromolecule metabolic process (GO:0044036)10.3839383
173binding of sperm to zona pellucida (GO:0007339)10.3112101
174cell-cell recognition (GO:0009988)10.0569424

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.79835887
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.29823436
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.32522376
4DROSHA_22980978_ChIP-Seq_HELA_Human3.09150024
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.07599060
6CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.76235628
7FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.61466007
8CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.50661487
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.43335132
10STAT6_21828071_ChIP-Seq_BEAS2B_Human2.40305095
11PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.35649512
12VDR_22108803_ChIP-Seq_LS180_Human2.16519261
13GATA1_26923725_Chip-Seq_HPCs_Mouse2.15622272
14MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse11.2298491
15EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.94843434
16FLI1_27457419_Chip-Seq_LIVER_Mouse1.94824804
17PIAS1_25552417_ChIP-Seq_VCAP_Human1.91324633
18ZNF274_21170338_ChIP-Seq_K562_Hela1.89259825
19NR3C1_21868756_ChIP-Seq_MCF10A_Human1.78816211
20PCGF2_27294783_Chip-Seq_ESCs_Mouse1.71936991
21ELK4_26923725_Chip-Seq_MESODERM_Mouse1.69473350
22FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.67514045
23AHR_22903824_ChIP-Seq_MCF-7_Human1.66704254
24STAT1_17558387_ChIP-Seq_HELA_Human1.66039111
25GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.64762235
26FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.64517537
27WDR5_24793694_ChIP-Seq_LNCAP_Human1.56270415
28CTBP1_25329375_ChIP-Seq_LNCAP_Human1.54249382
29AR_21572438_ChIP-Seq_LNCaP_Human1.53439269
30TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.52883986
31KAP1_22055183_ChIP-Seq_ESCs_Mouse1.52205079
32ARNT_22903824_ChIP-Seq_MCF-7_Human1.51238395
33KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.50711088
34SOX2_22085726_ChIP-Seq_NPCs_Mouse1.49713589
35ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.48422296
36STAT1_20625510_ChIP-Seq_HELA_Human1.47725071
37GATA3_21867929_ChIP-Seq_CD8_Mouse1.47360250
38ESR1_20079471_ChIP-ChIP_T-47D_Human1.46976902
39MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.45642867
40FOXM1_26456572_ChIP-Seq_MCF-7_Human1.43064535
41GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.41311796
42TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.41243312
43SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.41196460
44TOP2B_26459242_ChIP-Seq_MCF-7_Human1.41111055
45TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.39058943
46SMAD4_21799915_ChIP-Seq_A2780_Human1.38774024
47MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.37477997
48SMRT_27268052_Chip-Seq_Bcells_Human1.36901062
49IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.36266981
50CBP_20019798_ChIP-Seq_JUKART_Human1.36266981
51FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.35726232
52ETV1_20927104_ChIP-Seq_GIST48_Human1.35169054
53BCAT_22108803_ChIP-Seq_LS180_Human1.34615150
54RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.33944612
55SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.32572819
56NFE2_27457419_Chip-Seq_LIVER_Mouse1.31007362
57AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.30032078
58ER_23166858_ChIP-Seq_MCF-7_Human1.29280723
59TAL1_26923725_Chip-Seq_HPCs_Mouse1.28941887
60ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.28473653
61TDRD3_21172665_ChIP-Seq_MCF-7_Human1.28143028
62P53_21459846_ChIP-Seq_SAOS-2_Human1.27599977
63FOXA1_27270436_Chip-Seq_PROSTATE_Human1.27583915
64FOXA1_25329375_ChIP-Seq_VCAP_Human1.27583915
65STAT3_23295773_ChIP-Seq_U87_Human1.25991116
66TP63_23658742_ChIP-Seq_EP156T_Human1.25945105
67SMAD4_21741376_ChIP-Seq_EPCs_Human1.25137455
68GATA3_21867929_ChIP-Seq_TH1_Mouse1.24232288
69LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.23945623
70ESR1_21235772_ChIP-Seq_MCF-7_Human1.22972553
71CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.22787561
72PCGF2_27294783_Chip-Seq_NPCs_Mouse1.22646147
73PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.21979760
74CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.21610213
75FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.21048007
76PHF8_20622853_ChIP-Seq_HELA_Human1.20523008
77RBPJ_22232070_ChIP-Seq_NCS_Mouse1.20438436
78SMAD3_21741376_ChIP-Seq_EPCs_Human1.20120977
79PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.19020740
80RAD21_21589869_ChIP-Seq_MESCs_Mouse1.18650844
81YY1_22570637_ChIP-Seq_MALME-3M_Human1.18356990
82SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.18317765
83EZH2_27294783_Chip-Seq_ESCs_Mouse1.18083455
84PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.17000098
85PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.16849511
86KDM2B_26808549_Chip-Seq_REH_Human1.16738506
87TCF4_22108803_ChIP-Seq_LS180_Human1.16177061
88REST_21632747_ChIP-Seq_MESCs_Mouse1.15166997
89TP53_18474530_ChIP-ChIP_U2OS_Human1.14772354
90CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.14422612
91HNFA_21074721_ChIP-Seq_CACO-2_Human1.13687803
92AR_20517297_ChIP-Seq_VCAP_Human1.13462665
93SUZ12_27294783_Chip-Seq_NPCs_Mouse1.13043623
94AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.12170769
95RBPJ_21746931_ChIP-Seq_IB4_Human1.11174519
96VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.08447867
97GF1_26923725_Chip-Seq_HPCs_Mouse1.08239272
98GBX2_23144817_ChIP-Seq_PC3_Human1.08232736
99BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.08229453
100SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08216327
101TCF4_23295773_ChIP-Seq_U87_Human1.07610714
102TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.07405362
103RUNX1_26923725_Chip-Seq_HPCs_Mouse1.07037201
104GATA3_21878914_ChIP-Seq_MCF-7_Human1.06627145
105NCOR_22424771_ChIP-Seq_293T_Human1.06314776
106ZNF217_24962896_ChIP-Seq_MCF-7_Human1.06275704
107TP53_16413492_ChIP-PET_HCT116_Human1.05747566
108ERG_20517297_ChIP-Seq_VCAP_Human1.05654384
109PRDM14_20953172_ChIP-Seq_ESCs_Human1.05059161
110FOXA1_25552417_ChIP-Seq_VCAP_Human1.04862300
111POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.04776238
112TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04776238
113SPI1_26923725_Chip-Seq_HPCs_Mouse1.04436125
114TAF15_26573619_Chip-Seq_HEK293_Human1.04323035
115CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04183332
116EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.04096157
117NFYA_21822215_ChIP-Seq_K562_Human1.03793672
118RUNX2_22187159_ChIP-Seq_PCA_Human1.03741344
119CBX2_27304074_Chip-Seq_ESCs_Mouse1.03460703
120FLI1_21867929_ChIP-Seq_TH2_Mouse1.03411109
121POU3F2_20337985_ChIP-ChIP_501MEL_Human1.03298046
122CEBPB_22108803_ChIP-Seq_LS180_Human1.03231360
123CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03084531
124TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02969368
125EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.02398058
126CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.02358804
127CBX2_22325352_ChIP-Seq_293T-Rex_Human1.01963934
128SMC4_20622854_ChIP-Seq_HELA_Human1.01926461
129CRX_20693478_ChIP-Seq_RETINA_Mouse1.01028846
130EWS_26573619_Chip-Seq_HEK293_Human1.00880162
131RXRA_24833708_ChIP-Seq_LIVER_Mouse1.00804965
132PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.00784879
133RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.00275576
134TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.00203631
135GATA6_21074721_ChIP-Seq_CACO-2_Human1.00006600
136AR_25329375_ChIP-Seq_VCAP_Human0.99583096
137STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.99357261
138TBL1_22424771_ChIP-Seq_293T_Human0.98186214
139TP63_22573176_ChIP-Seq_HFKS_Human0.97975801
140RARA_24833708_ChIP-Seq_LIVER_Mouse0.97947021
141IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.97616719
142SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.97557955
143ZFP57_27257070_Chip-Seq_ESCs_Mouse0.97454290
144BMI1_23680149_ChIP-Seq_NPCS_Mouse0.97002054
145PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96872995
146OCT4_20526341_ChIP-Seq_ESCs_Human0.96634215
147GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.96363214
148ELF1_20517297_ChIP-Seq_JURKAT_Human0.96327283
149SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96158468
150RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.95986469
151CTCF_20526341_ChIP-Seq_ESCs_Human0.95424048
152NANOG_19829295_ChIP-Seq_ESCs_Human0.95391542
153SOX2_21211035_ChIP-Seq_LN229_Human0.94139828
154TET1_21451524_ChIP-Seq_MESCs_Mouse0.93493870
155MYC_27129775_Chip-Seq_CORNEA_Mouse0.93367835
156PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.92423532
157ESET_19884257_ChIP-Seq_ESCs_Mouse0.92177262
158NANOG_20526341_ChIP-Seq_ESCs_Human0.91872188
159ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.90787189
160OCT4_18555785_Chip-Seq_ESCs_Mouse0.90743737
161LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.90539803
162FLI1_21867929_ChIP-Seq_CD8_Mouse0.90258642
163CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.89962492
164TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89807839
165ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.89054260
166SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.87207841
167SOX11_22085726_ChIP-Seq_ESNs_Mouse0.86612537
168MYC_19829295_ChIP-Seq_ESCs_Human0.86226963
169CTBP2_25329375_ChIP-Seq_LNCAP_Human0.86122251
170OCT4_21477851_ChIP-Seq_ESCs_Mouse0.86091891
171RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.85922143
172NANOG_18555785_Chip-Seq_ESCs_Mouse0.84912184
173PHF8_20622854_ChIP-Seq_HELA_Human0.84835893
174NFYB_21822215_ChIP-Seq_K562_Human0.84114679
175KLF4_18555785_Chip-Seq_ESCs_Mouse0.82719612
176CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.82399911
177EZH2_27294783_Chip-Seq_NPCs_Mouse0.82149977
178P53_22387025_ChIP-Seq_ESCs_Mouse0.81453594
179GATA1_19941827_ChIP-Seq_MEL86_Mouse0.81208416

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008875_abnormal_xenobiotic_pharmacok6.14146181
2MP0003698_abnormal_male_reproductive6.03626892
3MP0001929_abnormal_gametogenesis5.56407385
4MP0008877_abnormal_DNA_methylation4.81281691
5MP0004043_abnormal_pH_regulation3.96436419
6MP0002210_abnormal_sex_determination3.73764759
7MP0002277_abnormal_respiratory_mucosa3.56244301
8MP0002161_abnormal_fertility/fecundity3.30542497
9MP0001145_abnormal_male_reproductive3.15161940
10MP0002653_abnormal_ependyma_morphology3.14867816
11MP0000653_abnormal_sex_gland2.72983950
12MP0005670_abnormal_white_adipose2.39760983
13MP0000383_abnormal_hair_follicle2.36158823
14MP0008789_abnormal_olfactory_epithelium2.33736691
15MP0009780_abnormal_chondrocyte_physiolo2.26451095
16MP0003136_yellow_coat_color2.07901692
17MP0003195_calcinosis2.05040963
18MP0005410_abnormal_fertilization15.5830798
19MP0002160_abnormal_reproductive_system1.91900581
20MP0005623_abnormal_meninges_morphology1.85627995
21MP0010678_abnormal_skin_adnexa1.68591815
22MP0003646_muscle_fatigue1.65364699
23MP0000566_synostosis1.58677787
24MP0005083_abnormal_biliary_tract1.54987256
25MP0003303_peritoneal_inflammation1.53200555
26MP0002282_abnormal_trachea_morphology1.49829664
27MP0002168_other_aberrant_phenotype1.49236894
28MP0002876_abnormal_thyroid_physiology1.48205667
29MP0002735_abnormal_chemical_nociception1.46145047
30MP0005394_taste/olfaction_phenotype1.43708665
31MP0005499_abnormal_olfactory_system1.43708665
32MP0008058_abnormal_DNA_repair1.41015933
33MP0002638_abnormal_pupillary_reflex1.40600313
34MP0001485_abnormal_pinna_reflex1.38506108
35MP0003656_abnormal_erythrocyte_physiolo1.33645708
36MP0002909_abnormal_adrenal_gland1.31030760
37MP0010094_abnormal_chromosome_stability1.26018812
38MP0002734_abnormal_mechanical_nocicepti1.21231996
39MP0008995_early_reproductive_senescence1.11255704
40MP0001346_abnormal_lacrimal_gland1.10826550
41MP0006082_CNS_inflammation1.08065907
42MP0001970_abnormal_pain_threshold1.05107656
43MP0008057_abnormal_DNA_replication1.05080359
44MP0004233_abnormal_muscle_weight1.04942105
45MP0009745_abnormal_behavioral_response1.04745204
46MP0005387_immune_system_phenotype1.03320233
47MP0001790_abnormal_immune_system1.03320233
48MP0001765_abnormal_ion_homeostasis1.02114835
49MP0003878_abnormal_ear_physiology1.01762076
50MP0005377_hearing/vestibular/ear_phenot1.01762076
51MP0005646_abnormal_pituitary_gland1.01252468
52MP0005389_reproductive_system_phenotype1.01172972
53MP0008872_abnormal_physiological_respon1.00446238
54MP0010155_abnormal_intestine_physiology0.98802197
55MP0003111_abnormal_nucleus_morphology0.98712034
56MP0000026_abnormal_inner_ear0.97131434
57MP0005395_other_phenotype0.96645687
58MP0009046_muscle_twitch0.94296069
59MP0005195_abnormal_posterior_eye0.94208519
60MP0001968_abnormal_touch/_nociception0.94119099
61MP0004885_abnormal_endolymph0.93786489
62MP0005365_abnormal_bile_salt0.92128365
63MP0001984_abnormal_olfaction0.91111082
64MP0005647_abnormal_sex_gland0.87693492
65MP0005165_increased_susceptibility_to0.85118856
66MP0009643_abnormal_urine_homeostasis0.84262127
67MP0003011_delayed_dark_adaptation0.82466743
68MP0002136_abnormal_kidney_physiology0.81722107
69MP0002148_abnormal_hypersensitivity_rea0.81147775
70MP0001486_abnormal_startle_reflex0.80902865
71MP0001502_abnormal_circadian_rhythm0.80615501
72MP0002139_abnormal_hepatobiliary_system0.80222514
73MP0003786_premature_aging0.79602914
74MP0009764_decreased_sensitivity_to0.78715371
75MP0003115_abnormal_respiratory_system0.78665835
76MP0002572_abnormal_emotion/affect_behav0.77899860
77MP0000631_abnormal_neuroendocrine_gland0.76853026
78MP0000358_abnormal_cell_content/0.76642251
79MP0002229_neurodegeneration0.75943019
80MP0005310_abnormal_salivary_gland0.75506682
81MP0001663_abnormal_digestive_system0.75100503
82MP0003693_abnormal_embryo_hatching0.74802363
83MP0001501_abnormal_sleep_pattern0.73912699
84MP0001963_abnormal_hearing_physiology0.72941295
85MP0005085_abnormal_gallbladder_physiolo0.72102393
86MP0005248_abnormal_Harderian_gland0.70258644
87MP0002557_abnormal_social/conspecific_i0.69592902
88MP0002272_abnormal_nervous_system0.68887434
89MP0008007_abnormal_cellular_replicative0.67794593
90MP0005397_hematopoietic_system_phenotyp0.66973769
91MP0001545_abnormal_hematopoietic_system0.66973769
92MP0009765_abnormal_xenobiotic_induced0.66328363
93MP0001944_abnormal_pancreas_morphology0.64671054
94MP0000678_abnormal_parathyroid_gland0.63844044
95MP0005167_abnormal_blood-brain_barrier0.60661472
96MP0002234_abnormal_pharynx_morphology0.60507569
97MP0000569_abnormal_digit_pigmentation0.59385282
98MP0005164_abnormal_response_to0.59247063
99MP0002233_abnormal_nose_morphology0.59064005
100MP0005220_abnormal_exocrine_pancreas0.58892040
101MP0005636_abnormal_mineral_homeostasis0.58850670
102MP0009785_altered_susceptibility_to0.58224605
103MP0004142_abnormal_muscle_tone0.58051092
104MP0001293_anophthalmia0.57782839
105MP0002332_abnormal_exercise_endurance0.57440012
106MP0009278_abnormal_bone_marrow0.57102341
107MP0002064_seizures0.56794638
108MP0003077_abnormal_cell_cycle0.55683858
109MP0003724_increased_susceptibility_to0.55230228
110MP0001664_abnormal_digestion0.55110215
111MP0003806_abnormal_nucleotide_metabolis0.54702550
112MP0001188_hyperpigmentation0.54411966
113MP0002249_abnormal_larynx_morphology0.53569832
114MP0000427_abnormal_hair_cycle0.53516129
115MP0003699_abnormal_female_reproductive0.53249214
116MP0003950_abnormal_plasma_membrane0.52605858
117MP0004808_abnormal_hematopoietic_stem0.49813342
118MP0001730_embryonic_growth_arrest0.48656985
119MP0001324_abnormal_eye_pigmentation0.47776861
120MP0001764_abnormal_homeostasis0.47515423
121MP0005666_abnormal_adipose_tissue0.46855962
122MP0003879_abnormal_hair_cell0.45873247
123MP0002102_abnormal_ear_morphology0.45216462
124MP0001119_abnormal_female_reproductive0.43367432
125MP0001986_abnormal_taste_sensitivity0.42951309
126MP0006036_abnormal_mitochondrial_physio0.40727860
127MP0000313_abnormal_cell_death0.39295904
128MP0002928_abnormal_bile_duct0.39046238
129MP0006035_abnormal_mitochondrial_morpho0.38617652
130MP0005253_abnormal_eye_physiology0.38469737
131MP0005391_vision/eye_phenotype0.37272297
132MP0004957_abnormal_blastocyst_morpholog0.35965703
133MP0005551_abnormal_eye_electrophysiolog0.33539018
134MP0009115_abnormal_fat_cell0.31954692
135MP0005174_abnormal_tail_pigmentation0.31661851
136MP0002132_abnormal_respiratory_system0.31174944
137MP0001661_extended_life_span0.31078101
138MP0010307_abnormal_tumor_latency0.31060510
139MP0000015_abnormal_ear_pigmentation0.29379960
140MP0002269_muscular_atrophy0.27807727
141MP0001727_abnormal_embryo_implantation0.27769915
142MP0002796_impaired_skin_barrier0.27300348
143MP0004019_abnormal_vitamin_homeostasis0.27254296
144MP0003861_abnormal_nervous_system0.27234184
145MP0004133_heterotaxia0.26919765
146MP0002092_abnormal_eye_morphology0.26889817
147MP0002971_abnormal_brown_adipose0.26871471
148MP0003329_amyloid_beta_deposits0.26547732
149MP0005380_embryogenesis_phenotype0.26085339
150MP0001672_abnormal_embryogenesis/_devel0.26085339
151MP0004036_abnormal_muscle_relaxation0.25473647
152MP0003942_abnormal_urinary_system0.25470567
153MP0001697_abnormal_embryo_size0.24258632
154MP0002084_abnormal_developmental_patter0.23705150
155MP0008932_abnormal_embryonic_tissue0.23585937
156MP0005423_abnormal_somatic_nervous0.23493694
157MP0004742_abnormal_vestibular_system0.23448753
158MP0003936_abnormal_reproductive_system0.21920044
159MP0002080_prenatal_lethality0.20589368
160MP0002169_no_abnormal_phenotype0.20238996
161MP0002405_respiratory_system_inflammati0.19940623
162MP0002873_normal_phenotype0.19844315
163MP0002152_abnormal_brain_morphology0.19122321
164MP0000534_abnormal_ureter_morphology0.18244164
165MP0003315_abnormal_perineum_morphology0.17781376
166MP0002736_abnormal_nociception_after0.17758776
167MP0003948_abnormal_gas_homeostasis0.17486320
168MP0003984_embryonic_growth_retardation0.16561930
169MP0004811_abnormal_neuron_physiology0.16066026
170MP0009672_abnormal_birth_weight0.15967926
171MP0000001_mammalian_phenotype0.15525752
172MP0002085_abnormal_embryonic_tissue0.14705750
173MP0002088_abnormal_embryonic_growth/wei0.14572020

Predicted human phenotypes

RankGene SetZ-score
1Rhinitis (HP:0012384)8.56735380
2Abnormal ciliary motility (HP:0012262)8.00491112
3* Abnormal respiratory motile cilium morphology (HP:0005938)7.73368602
4* Abnormal respiratory epithelium morphology (HP:0012253)7.73368602
5Chronic bronchitis (HP:0004469)7.61641627
6Nasal polyposis (HP:0100582)6.99421146
7* Infertility (HP:0000789)6.51721489
8Abnormality of the nasal mucosa (HP:0000433)5.72047364
9Nephronophthisis (HP:0000090)4.89105197
10Male infertility (HP:0003251)4.76067926
11* Bronchiectasis (HP:0002110)4.38838154
12Abnormal spermatogenesis (HP:0008669)3.89114157
13* Bronchitis (HP:0012387)3.83474201
14Abnormality of the renal medulla (HP:0100957)3.71870730
15Occipital encephalocele (HP:0002085)3.71312178
16Pancreatic cysts (HP:0001737)3.67008732
17Chronic hepatic failure (HP:0100626)3.51018716
18Recurrent sinusitis (HP:0011108)3.50683589
19Impulsivity (HP:0100710)3.45081522
20Tubulointerstitial nephritis (HP:0001970)3.29511896
21Gonadotropin excess (HP:0000837)3.23407542
22Chronic otitis media (HP:0000389)3.15198927
23* Recurrent otitis media (HP:0000403)2.83219340
24Molar tooth sign on MRI (HP:0002419)2.79702266
25Abnormality of midbrain morphology (HP:0002418)2.79702266
26Tubular atrophy (HP:0000092)2.77068964
27Azoospermia (HP:0000027)2.68510768
28Tubulointerstitial abnormality (HP:0001969)2.63721718
29Hyperactive renin-angiotensin system (HP:0000841)2.63373140
30Absent rod-and cone-mediated responses on ERG (HP:0007688)2.58813063
31Abnormality of the lower motor neuron (HP:0002366)2.57558032
32Atelectasis (HP:0100750)2.56866364
33Medial flaring of the eyebrow (HP:0010747)2.54378779
34Anencephaly (HP:0002323)2.31559350
35Hypoplasia of the capital femoral epiphysis (HP:0003090)2.26522778
36Decreased circulating renin level (HP:0003351)2.25871392
37Postaxial foot polydactyly (HP:0001830)2.23639946
38Spastic tetraparesis (HP:0001285)2.22466513
39Male pseudohermaphroditism (HP:0000037)2.20079175
40Abnormal gallbladder physiology (HP:0012438)2.14016586
41Cholecystitis (HP:0001082)2.14016586
42Amyotrophic lateral sclerosis (HP:0007354)2.12764707
43Stage 5 chronic kidney disease (HP:0003774)2.06422426
44Sclerocornea (HP:0000647)2.04311169
45Fibular hypoplasia (HP:0003038)2.03448120
46Furrowed tongue (HP:0000221)2.02056199
47Respiratory insufficiency due to defective ciliary clearance (HP:0200073)14.3214661
48* Dynein arm defect of respiratory motile cilia (HP:0012255)10.5802463
49* Absent/shortened dynein arms (HP:0200106)10.5802463
50Abnormal respiratory motile cilium physiology (HP:0012261)10.0368784
51Congenital hepatic fibrosis (HP:0002612)1.99184745
52Tubulointerstitial fibrosis (HP:0005576)1.98792774
53Abnormal rod and cone electroretinograms (HP:0008323)1.96315528
54Aplasia/Hypoplasia of the spleen (HP:0010451)1.96204541
55Short ribs (HP:0000773)1.94247696
56Asplenia (HP:0001746)1.93277617
57Dyschromatopsia (HP:0007641)1.92418764
58Polydipsia (HP:0001959)1.86976100
59Abnormal drinking behavior (HP:0030082)1.86976100
60Oculomotor apraxia (HP:0000657)1.86826657
61Nephrogenic diabetes insipidus (HP:0009806)1.86480109
62Heterotopia (HP:0002282)1.85615652
63Abnormality of the renal cortex (HP:0011035)1.84940147
64Abnormality of permanent molar morphology (HP:0011071)1.83168189
65Abnormality of the dental root (HP:0006486)1.83168189
66Taurodontia (HP:0000679)1.83168189
67Abnormal biliary tract physiology (HP:0012439)1.82236205
68Bile duct proliferation (HP:0001408)1.82236205
69Impaired proprioception (HP:0010831)1.82182586
70Facial cleft (HP:0002006)1.82114534
71Supernumerary spleens (HP:0009799)1.79174069
72Renal dysplasia (HP:0000110)1.78597218
73Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.78272559
74Absent epiphyses (HP:0010577)1.78272559
75Bell-shaped thorax (HP:0001591)1.77270012
76Renal salt wasting (HP:0000127)1.73706031
77Chronic sinusitis (HP:0011109)1.72953726
78Microglossia (HP:0000171)1.70273690
79Abnormality of molar (HP:0011077)1.69598816
80Abnormality of molar morphology (HP:0011070)1.69598816
81Abnormality of dentin (HP:0010299)1.68910610
82Choroideremia (HP:0001139)1.68864890
83Abnormality of the dental pulp (HP:0006479)1.67938561
84Decreased central vision (HP:0007663)1.67619694
85Abnormality of renal excretion (HP:0011036)1.64996861
86J-shaped sella turcica (HP:0002680)1.64599100
87Postaxial hand polydactyly (HP:0001162)1.61803723
88Absent frontal sinuses (HP:0002688)1.59867654
89Pancreatic fibrosis (HP:0100732)1.59508088
90Median cleft lip (HP:0000161)1.56140666
91Abnormality of renin-angiotensin system (HP:0000847)1.54716798
92Hyperkalemia (HP:0002153)1.51724224
93Cystic liver disease (HP:0006706)1.50833126
94Genital tract atresia (HP:0001827)1.50513903
95Deformed sella turcica (HP:0002681)1.50420733
96Hyperaldosteronism (HP:0000859)1.50254745
97Vaginal atresia (HP:0000148)1.50097224
98Broad distal phalanx of finger (HP:0009836)1.49238068
99Cone-rod dystrophy (HP:0000548)1.48746458
100Abnormality of the anterior horn cell (HP:0006802)1.48702720
101Degeneration of anterior horn cells (HP:0002398)1.48702720
102Preaxial hand polydactyly (HP:0001177)1.47151311
103Aplasia/Hypoplasia of the tongue (HP:0010295)1.45664225
104Short thorax (HP:0010306)1.45624801
105Poor coordination (HP:0002370)1.43634091
106Nephropathy (HP:0000112)1.42150175
107Short femoral neck (HP:0100864)1.36673017
108Hypokalemic alkalosis (HP:0001949)1.36416541
109Hemiparesis (HP:0001269)1.36333969
110Abnormal urine output (HP:0012590)1.35161189
111Aplasia/Hypoplasia of the lens (HP:0008063)1.34128466
112Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.34007954
113Retinitis pigmentosa (HP:0000510)1.33949209
114Cerebellar dysplasia (HP:0007033)1.33635689
115True hermaphroditism (HP:0010459)1.33255175
116Abnormality of chloride homeostasis (HP:0011422)1.32836710
117Bony spicule pigmentary retinopathy (HP:0007737)1.31353393
118Short nail (HP:0001799)1.30181110
119Bundle branch block (HP:0011710)1.28831108
120Congenital primary aphakia (HP:0007707)1.28746839
121Hemorrhage of the eye (HP:0011885)1.28434041
122Gait imbalance (HP:0002141)1.26769390
123Pachygyria (HP:0001302)1.25934504
124Sloping forehead (HP:0000340)1.25843724
125Polyuria (HP:0000103)1.24143114
126Aplasia/Hypoplasia of the fibula (HP:0006492)1.23194315
127Decreased electroretinogram (ERG) amplitude (HP:0000654)1.22745664
128Absent speech (HP:0001344)1.22550265
129Glucose intolerance (HP:0000833)1.22374864
130Type II lissencephaly (HP:0007260)1.21881007
131Lissencephaly (HP:0001339)1.20902618
132Abnormality of ocular smooth pursuit (HP:0000617)1.20250533
133Abnormality of macular pigmentation (HP:0008002)1.13635577
134Narrow forehead (HP:0000341)1.12792525
135Abolished electroretinogram (ERG) (HP:0000550)1.12413403
136Multicystic kidney dysplasia (HP:0000003)1.08258240
137Prominent nasal bridge (HP:0000426)1.07983600
138Aganglionic megacolon (HP:0002251)1.07745565
139Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.05677762
140Holoprosencephaly (HP:0001360)1.02027871
141Macular degeneration (HP:0000608)1.00723602
142Alveolar cell carcinoma (HP:0006519)0.99366285
143Portal hypertension (HP:0001409)0.98962386

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK38.14386104
2PDK48.14386104
3TESK15.93712827
4PDK25.23746619
5PRKD35.13662459
6MST44.77192210
7ICK4.01908131
8EPHA22.86356972
9PNCK2.80659899
10WNK42.26085714
11FRK2.24399026
12PTK2B2.21551701
13STK392.12739076
14ADRBK22.07135728
15NEK22.02006769
16MAPKAPK31.97641045
17NME11.83884023
18STK381.70417690
19BCR1.59284881
20DYRK1B1.48693210
21GRK11.35925722
22INSRR1.25927620
23MAP4K21.17598649
24ACVR1B1.17262773
25CSK1.16650795
26MAP3K21.15371887
27MAPK151.13847380
28MAP3K41.12989264
29STK241.12386528
30EPHA31.11793409
31DYRK31.07084174
32WEE11.06101497
33TBK11.04516901
34CAMKK21.00860815
35TXK0.97475773
36TTK0.93694309
37WNK10.92515239
38GRK70.89613673
39PDK10.87731735
40OXSR10.86179602
41MAP3K70.85402543
42CCNB10.84365374
43PASK0.82488697
44TYRO30.81856085
45PRKCI0.81723127
46TAOK30.80971179
47STK30.79182407
48ADRBK10.73890210
49MAPK130.71896293
50CHEK20.71516948
51IRAK10.70018811
52MAP3K30.69894183
53TRPM70.69702734
54MAP2K70.69070768
55ERBB20.67888394
56TESK20.67428107
57PLK40.63879014
58CHUK0.63170212
59CDC70.60347595
60IKBKE0.59840791
61ERBB30.57434196
62PINK10.57135122
63IKBKB0.57033135
64CHEK10.54847160
65BUB10.53656623
66MATK0.52852158
67CAMK1G0.51154944
68ATR0.48951574
69LMTK20.47665462
70PAK10.47533572
71ZAK0.46635904
72BRSK20.45227806
73MAP2K60.44903548
74PLK10.43463824
75MAP2K20.43113598
76PDPK10.42580214
77PRKCE0.41588642
78NLK0.40611129
79EPHB10.40609706
80HIPK20.39167276
81ATM0.38150290
82IRAK20.37882088
83PRKAA20.37820835
84PRKCD0.36571078
85PRKACA0.36495763
86RIPK40.35633504
87TYK20.35093994
88CASK0.34892208
89SGK10.34455975
90PKN10.33579181
91STK38L0.32980551
92ABL10.32602949
93EEF2K0.32203306
94CAMK2A0.31623836
95PRKCA0.31277779
96MTOR0.30786835
97DAPK20.30539911
98IRAK40.30146023
99PAK20.29338655
100NTRK30.29001449
101BMPR1B0.28992518
102MAP2K40.28832063
103GRK60.27779371
104PRKCG0.26969015
105TGFBR10.26677157
106MKNK20.26292988
107DYRK1A0.25826536
108MUSK0.25552349
109CDC42BPA0.25548329
110BRSK10.24584243
111LRRK20.24558186
112PAK30.24245751
113NTRK20.23120170
114MAPKAPK50.21870327
115PRKAA10.21168516
116DYRK20.19975995
117TSSK60.19690974
118FER0.19602147
119EGFR0.19394653
120BRAF0.19271697
121TLK10.19106160
122NEK60.18720189
123CAMK2G0.18713285
124MARK20.18345257
125SRPK10.17739109
126PAK40.17285666
127AURKA0.15464679
128MAP3K100.13979857
129CSNK2A10.13727985
130CAMKK10.13093199
131RPS6KB10.11362154
132STK160.10246914
133CDK20.10238443
134CSNK2A20.09259476
135TAOK10.08608030
136CDK10.08475476
137MARK30.07980986
138PRKCZ0.07497692
139CDK30.07476105
140PIM10.06916438
141CDK120.06895394
142AURKB0.06835869
143WNK30.06665145
144CDK40.06454057
145ZAP700.06000186
146GSK3B0.05414360
147RPS6KA10.05104462
148STK110.03997878
149EIF2AK10.03677750
150CDK150.03281853
151CSNK1D0.02560223
152CDK11A0.02371589
153STK100.02164660
154PRKDC0.01223370
155PRKCQ0.01027407
156CDK180.00918330
157YES10.00285971
158CLK10.00125657
159PRKCB-0.0301773
160CDK14-0.0300328
161PLK3-0.0292113
162PRKG1-0.0253058
163PRKACB-0.0247799
164PRKACG-0.0228286
165CDK6-0.0189947
166MAP3K5-0.0169540
167MAPK8-0.0011960

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007504.26182541
2Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.03418718
3Fatty acid biosynthesis_Homo sapiens_hsa000613.57277481
4Histidine metabolism_Homo sapiens_hsa003403.56465145
5Pyruvate metabolism_Homo sapiens_hsa006203.39924490
6Phenylalanine metabolism_Homo sapiens_hsa003603.25710761
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.98015542
8Basal transcription factors_Homo sapiens_hsa030222.96987979
9Linoleic acid metabolism_Homo sapiens_hsa005912.93942354
10Tyrosine metabolism_Homo sapiens_hsa003502.54698086
11Caffeine metabolism_Homo sapiens_hsa002322.53307345
12Fanconi anemia pathway_Homo sapiens_hsa034602.49181845
13Dorso-ventral axis formation_Homo sapiens_hsa043202.42332918
14Glucagon signaling pathway_Homo sapiens_hsa049222.41072782
15beta-Alanine metabolism_Homo sapiens_hsa004102.40574375
16Propanoate metabolism_Homo sapiens_hsa006402.39439085
17Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.39422581
18Selenocompound metabolism_Homo sapiens_hsa004502.34343994
19Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.26251931
20Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.22147793
21Oocyte meiosis_Homo sapiens_hsa041142.07293952
22Carbohydrate digestion and absorption_Homo sapiens_hsa049732.06871782
23Huntingtons disease_Homo sapiens_hsa050162.02720884
24Pentose phosphate pathway_Homo sapiens_hsa000302.01793379
25Retinol metabolism_Homo sapiens_hsa008301.96354917
26Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.96233296
27Glycerolipid metabolism_Homo sapiens_hsa005611.94227415
28RNA transport_Homo sapiens_hsa030131.94185655
29Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.89258629
30Glycerophospholipid metabolism_Homo sapiens_hsa005641.79510732
31Fructose and mannose metabolism_Homo sapiens_hsa000511.72463805
32mRNA surveillance pathway_Homo sapiens_hsa030151.62948334
33Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.60470523
34Antigen processing and presentation_Homo sapiens_hsa046121.49527962
35Steroid hormone biosynthesis_Homo sapiens_hsa001401.48302845
36Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.47875563
37Phototransduction_Homo sapiens_hsa047441.45107841
38PPAR signaling pathway_Homo sapiens_hsa033201.45066896
39Intestinal immune network for IgA production_Homo sapiens_hsa046721.44901969
40Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.44169477
41Purine metabolism_Homo sapiens_hsa002301.43070765
42Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.36755380
43Amphetamine addiction_Homo sapiens_hsa050311.35721380
44Cardiac muscle contraction_Homo sapiens_hsa042601.33655586
45Cysteine and methionine metabolism_Homo sapiens_hsa002701.32986761
46Ether lipid metabolism_Homo sapiens_hsa005651.32213003
47Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.27968995
48Peroxisome_Homo sapiens_hsa041461.27205433
49Nicotine addiction_Homo sapiens_hsa050331.27200492
50Asthma_Homo sapiens_hsa053101.25972390
51Carbon metabolism_Homo sapiens_hsa012001.23684596
52Mineral absorption_Homo sapiens_hsa049781.23029081
53Fat digestion and absorption_Homo sapiens_hsa049751.22405583
54Nitrogen metabolism_Homo sapiens_hsa009101.16903492
55Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.15401647
56Tryptophan metabolism_Homo sapiens_hsa003801.13755697
57Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.13385068
58Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.08023431
59Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.07785670
60Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.05992016
61Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.05957370
62Allograft rejection_Homo sapiens_hsa053301.05914541
63Primary bile acid biosynthesis_Homo sapiens_hsa001201.05328106
64Pyrimidine metabolism_Homo sapiens_hsa002401.05109093
65Glycosaminoglycan degradation_Homo sapiens_hsa005311.01262291
66Salivary secretion_Homo sapiens_hsa049700.98050578
67Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.98036812
68Olfactory transduction_Homo sapiens_hsa047400.97984623
69Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.96762400
70Arachidonic acid metabolism_Homo sapiens_hsa005900.95928509
71Graft-versus-host disease_Homo sapiens_hsa053320.95342472
72Homologous recombination_Homo sapiens_hsa034400.92591889
73Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.89534646
74Type I diabetes mellitus_Homo sapiens_hsa049400.89093446
75Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.88973211
76Renin secretion_Homo sapiens_hsa049240.87601702
77Circadian rhythm_Homo sapiens_hsa047100.86936008
78Rheumatoid arthritis_Homo sapiens_hsa053230.86493408
79Fatty acid metabolism_Homo sapiens_hsa012120.85709784
80Glutathione metabolism_Homo sapiens_hsa004800.85264827
81Fatty acid degradation_Homo sapiens_hsa000710.83935388
82Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.82202385
83Hedgehog signaling pathway_Homo sapiens_hsa043400.82174619
84Proteasome_Homo sapiens_hsa030500.81885715
85Hematopoietic cell lineage_Homo sapiens_hsa046400.81615756
86Butanoate metabolism_Homo sapiens_hsa006500.81396436
87Autoimmune thyroid disease_Homo sapiens_hsa053200.81361942
88Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.77768878
89RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.73817063
90Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.71371056
91Biosynthesis of amino acids_Homo sapiens_hsa012300.71337225
92Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.70635452
93Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.70287328
94Tight junction_Homo sapiens_hsa045300.70213013
95Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.68527978
96DNA replication_Homo sapiens_hsa030300.67917231
97Legionellosis_Homo sapiens_hsa051340.67640747
98Spliceosome_Homo sapiens_hsa030400.65286428
99RNA degradation_Homo sapiens_hsa030180.64438600
100Starch and sucrose metabolism_Homo sapiens_hsa005000.63743535
101NOD-like receptor signaling pathway_Homo sapiens_hsa046210.63691185
102Estrogen signaling pathway_Homo sapiens_hsa049150.62947925
103Systemic lupus erythematosus_Homo sapiens_hsa053220.61368920
104Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.58821460
105Maturity onset diabetes of the young_Homo sapiens_hsa049500.58539834
106Serotonergic synapse_Homo sapiens_hsa047260.57936769
107Cell cycle_Homo sapiens_hsa041100.57713620
108Renin-angiotensin system_Homo sapiens_hsa046140.55848142
109Collecting duct acid secretion_Homo sapiens_hsa049660.55752507
110Long-term potentiation_Homo sapiens_hsa047200.54907976
111Adipocytokine signaling pathway_Homo sapiens_hsa049200.53085266
112Jak-STAT signaling pathway_Homo sapiens_hsa046300.52690894
113Ovarian steroidogenesis_Homo sapiens_hsa049130.52684933
114Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.52563755
115Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.52507663
116ABC transporters_Homo sapiens_hsa020100.51046718
117Chemical carcinogenesis_Homo sapiens_hsa052040.47938979
118Lysosome_Homo sapiens_hsa041420.47323461
119Drug metabolism - other enzymes_Homo sapiens_hsa009830.46879933
120Central carbon metabolism in cancer_Homo sapiens_hsa052300.46558523
121Metabolic pathways_Homo sapiens_hsa011000.45876983
122Vitamin digestion and absorption_Homo sapiens_hsa049770.45501494
123Hepatitis C_Homo sapiens_hsa051600.45482519
124Oxidative phosphorylation_Homo sapiens_hsa001900.44084623
125Endocytosis_Homo sapiens_hsa041440.42157301
126Regulation of autophagy_Homo sapiens_hsa041400.42099876
127Base excision repair_Homo sapiens_hsa034100.41931738
128AMPK signaling pathway_Homo sapiens_hsa041520.41893034
129TNF signaling pathway_Homo sapiens_hsa046680.41277074
130Cocaine addiction_Homo sapiens_hsa050300.40518626
131cAMP signaling pathway_Homo sapiens_hsa040240.40478566
132cGMP-PKG signaling pathway_Homo sapiens_hsa040220.40234118
133Insulin secretion_Homo sapiens_hsa049110.39030374
134Thyroid hormone synthesis_Homo sapiens_hsa049180.38714267
135Calcium signaling pathway_Homo sapiens_hsa040200.37828444
136Nucleotide excision repair_Homo sapiens_hsa034200.37495511
137Inositol phosphate metabolism_Homo sapiens_hsa005620.36695113
138N-Glycan biosynthesis_Homo sapiens_hsa005100.35818601
139VEGF signaling pathway_Homo sapiens_hsa043700.33786636
140Epstein-Barr virus infection_Homo sapiens_hsa051690.33144152
141African trypanosomiasis_Homo sapiens_hsa051430.32878913
142Protein digestion and absorption_Homo sapiens_hsa049740.32680724
143Staphylococcus aureus infection_Homo sapiens_hsa051500.32463639
144Phosphatidylinositol signaling system_Homo sapiens_hsa040700.31701829
145Taste transduction_Homo sapiens_hsa047420.31360456
146Notch signaling pathway_Homo sapiens_hsa043300.30175412
147Transcriptional misregulation in cancer_Homo sapiens_hsa052020.28601877
148Sphingolipid metabolism_Homo sapiens_hsa006000.28096317
149Pancreatic secretion_Homo sapiens_hsa049720.27438762
150Toll-like receptor signaling pathway_Homo sapiens_hsa046200.27158890
151Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.26973184
152Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.26690145
153Alcoholism_Homo sapiens_hsa050340.24656104
154Glutamatergic synapse_Homo sapiens_hsa047240.24048068
155SNARE interactions in vesicular transport_Homo sapiens_hsa041300.23386258
156Pentose and glucuronate interconversions_Homo sapiens_hsa000400.22404983
157NF-kappa B signaling pathway_Homo sapiens_hsa040640.22141865
158Bile secretion_Homo sapiens_hsa049760.22003606
159Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.21421920
160Complement and coagulation cascades_Homo sapiens_hsa046100.20096091
161Thyroid hormone signaling pathway_Homo sapiens_hsa049190.18639436
162Viral carcinogenesis_Homo sapiens_hsa052030.18560760
163Basal cell carcinoma_Homo sapiens_hsa052170.18466491
164Vascular smooth muscle contraction_Homo sapiens_hsa042700.18419841
165Wnt signaling pathway_Homo sapiens_hsa043100.16649483
166Alzheimers disease_Homo sapiens_hsa050100.15333102
167Synaptic vesicle cycle_Homo sapiens_hsa047210.13544186

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