DNAAF2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a highly conserved protein involved in the preassembly of dynein arm complexes which power cilia. These complexes are found in some cilia and are assembled in the cytoplasm prior to transport for cilia formation. Mutations in this gene have been associated with primary ciliary dyskinesia. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hindbrain development (GO:0030902)5.47294330
2tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)5.13520636
3RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)5.13520636
4DNA strand elongation involved in DNA replication (GO:0006271)4.99943954
5DNA strand elongation (GO:0022616)4.80000507
6DNA replication initiation (GO:0006270)4.74781437
7telomere maintenance via semi-conservative replication (GO:0032201)4.74349598
8seminiferous tubule development (GO:0072520)4.70218073
9DNA replication checkpoint (GO:0000076)4.55827093
10CENP-A containing nucleosome assembly (GO:0034080)4.32972558
11single strand break repair (GO:0000012)4.31064340
12telomere maintenance via recombination (GO:0000722)4.30289571
13chromatin remodeling at centromere (GO:0031055)4.25492672
14somatic hypermutation of immunoglobulin genes (GO:0016446)4.20071649
15somatic diversification of immune receptors via somatic mutation (GO:0002566)4.20071649
16histone H4-K12 acetylation (GO:0043983)4.18253411
17ribosomal small subunit assembly (GO:0000028)4.18130568
18DNA unwinding involved in DNA replication (GO:0006268)4.17659249
19maturation of SSU-rRNA (GO:0030490)4.17517518
20DNA deamination (GO:0045006)4.12720105
21mitotic recombination (GO:0006312)4.08130833
22mitotic metaphase plate congression (GO:0007080)4.07221477
23nucleobase biosynthetic process (GO:0046112)4.07199869
24L-methionine biosynthetic process from methylthioadenosine (GO:0019509)4.03948966
25negative regulation of translation involved in gene silencing by miRNA (GO:0035278)4.02802145
26negative regulation of translation, ncRNA-mediated (GO:0040033)4.02802145
27regulation of translation, ncRNA-mediated (GO:0045974)4.02802145
28purine nucleobase biosynthetic process (GO:0009113)4.02401921
29kinetochore organization (GO:0051383)4.02338978
30DNA replication-independent nucleosome assembly (GO:0006336)3.96887101
31DNA replication-independent nucleosome organization (GO:0034724)3.96887101
32regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.95207276
33rRNA transcription (GO:0009303)3.94451877
34protein localization to kinetochore (GO:0034501)3.84455629
35nucleotide-excision repair, DNA gap filling (GO:0006297)3.82159249
36histone exchange (GO:0043486)3.81525019
37kinetochore assembly (GO:0051382)3.80818123
38telomere maintenance via telomere lengthening (GO:0010833)3.78856130
39DNA double-strand break processing (GO:0000729)3.73235373
40DNA replication-dependent nucleosome organization (GO:0034723)3.70495351
41DNA replication-dependent nucleosome assembly (GO:0006335)3.70495351
42ribosome biogenesis (GO:0042254)3.69565035
43ribosomal large subunit biogenesis (GO:0042273)3.68193749
44cellular response to ATP (GO:0071318)3.68019087
45mitotic nuclear envelope disassembly (GO:0007077)3.65426883
46protein localization to chromosome, centromeric region (GO:0071459)3.64503684
47uterus development (GO:0060065)3.62700155
48metaphase plate congression (GO:0051310)3.60828198
49ribonucleoprotein complex biogenesis (GO:0022613)3.59014706
50homocysteine metabolic process (GO:0050667)3.55960250
51formation of translation preinitiation complex (GO:0001731)3.55870896
52spliceosomal snRNP assembly (GO:0000387)3.54080176
53viral transcription (GO:0019083)3.49929647
54mitochondrial RNA metabolic process (GO:0000959)3.48286726
55translational termination (GO:0006415)3.47680195
56IMP biosynthetic process (GO:0006188)3.46947231
57ribosome assembly (GO:0042255)3.41147323
58nuclear pore organization (GO:0006999)3.40669115
59transcription elongation from RNA polymerase I promoter (GO:0006362)3.40219616
60L-serine metabolic process (GO:0006563)3.38558608
61membrane disassembly (GO:0030397)3.34126789
62nuclear envelope disassembly (GO:0051081)3.34126789
63ribosomal small subunit biogenesis (GO:0042274)3.32895882
64proteasome assembly (GO:0043248)3.32316087
65L-methionine salvage (GO:0071267)3.32087007
66L-methionine biosynthetic process (GO:0071265)3.32087007
67amino acid salvage (GO:0043102)3.32087007
68termination of RNA polymerase I transcription (GO:0006363)3.31680637
69regulation of double-strand break repair via homologous recombination (GO:0010569)3.31554382
70transcription-coupled nucleotide-excision repair (GO:0006283)3.30991182
71DNA ligation (GO:0006266)3.26552304
72rRNA processing (GO:0006364)3.25732644
73protein localization to synapse (GO:0035418)3.25534249
74translational initiation (GO:0006413)3.25069790
75deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.24137580
76regulation of spindle organization (GO:0090224)3.23891554
77replication fork processing (GO:0031297)3.21560401
78establishment of chromosome localization (GO:0051303)3.20101496
79cell fate commitment involved in formation of primary germ layer (GO:0060795)3.19901160
80nuclear pore complex assembly (GO:0051292)3.19063125
81translational elongation (GO:0006414)3.18616266
82mitotic sister chromatid segregation (GO:0000070)3.17568493
83rRNA metabolic process (GO:0016072)3.17455784
84regulation of nuclear cell cycle DNA replication (GO:0033262)3.16201543
85attachment of spindle microtubules to kinetochore (GO:0008608)3.15625793
86tongue development (GO:0043586)3.15426619
87positive regulation of inositol phosphate biosynthetic process (GO:0060732)3.14869494
88translesion synthesis (GO:0019985)3.14344347
89regulation of centrosome cycle (GO:0046605)3.11461023
90regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.11009401
91regulation of centriole replication (GO:0046599)3.09803622
92response to pheromone (GO:0019236)3.06122233
93anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.06030307
94telomere maintenance (GO:0000723)3.04404385
95telomere organization (GO:0032200)3.04289877
96termination of RNA polymerase III transcription (GO:0006386)3.02047420
97transcription elongation from RNA polymerase III promoter (GO:0006385)3.02047420
98nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.01942307
99mitochondrial respiratory chain complex I assembly (GO:0032981)3.01745772
100NADH dehydrogenase complex assembly (GO:0010257)3.01745772
101mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.01745772
102regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.01365250
103peptidyl-arginine omega-N-methylation (GO:0035247)3.01117948
104pseudouridine synthesis (GO:0001522)3.00406893
105galactose catabolic process (GO:0019388)2.99493741
106ATP-dependent chromatin remodeling (GO:0043044)2.98600059
107chromatin assembly or disassembly (GO:0006333)2.98556884
108G1/S transition of mitotic cell cycle (GO:0000082)2.98259411
109cell cycle G1/S phase transition (GO:0044843)2.98259411
110negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.97724049
111DNA damage response, detection of DNA damage (GO:0042769)2.97554774
112spindle checkpoint (GO:0031577)2.97550145
113intra-S DNA damage checkpoint (GO:0031573)2.97387023
114negative regulation of mitotic sister chromatid separation (GO:2000816)2.96642394
115negative regulation of mitotic sister chromatid segregation (GO:0033048)2.96642394
116negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.96642394
117negative regulation of sister chromatid segregation (GO:0033046)2.96642394
118regulation of bile acid biosynthetic process (GO:0070857)2.96336972
119deoxyribonucleotide biosynthetic process (GO:0009263)2.95936838
120folic acid-containing compound biosynthetic process (GO:0009396)2.95680498
121negative regulation of chromosome segregation (GO:0051985)2.95613992
122protein K6-linked ubiquitination (GO:0085020)2.95554086
123SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.95003546
124regulation of chromosome segregation (GO:0051983)2.94450268
125IMP metabolic process (GO:0046040)2.92880473
126DNA catabolic process, exonucleolytic (GO:0000738)2.92590629
127pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.92072151
128positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.91682676
129rRNA modification (GO:0000154)2.91416358
130mismatch repair (GO:0006298)2.90823827
131DNA duplex unwinding (GO:0032508)2.90220893
132microtubule depolymerization (GO:0007019)2.89229544
133DNA geometric change (GO:0032392)2.88885348
134sister chromatid segregation (GO:0000819)2.88780736
135establishment of integrated proviral latency (GO:0075713)2.88067852
136cotranslational protein targeting to membrane (GO:0006613)2.87437353
137histone H2A acetylation (GO:0043968)2.87165460
138negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.86707219
139inner mitochondrial membrane organization (GO:0007007)2.86137350
140regulation of mitotic metaphase/anaphase transition (GO:0030071)2.86054606
141protein targeting to ER (GO:0045047)2.85048705
142viral mRNA export from host cell nucleus (GO:0046784)2.83777648
143histone arginine methylation (GO:0034969)2.83590044
144inner ear receptor cell development (GO:0060119)2.82166773
145regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.81976189
146regulation of mitotic spindle checkpoint (GO:1903504)2.81976189
147exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.81300896
148sulfur amino acid biosynthetic process (GO:0000097)2.81244082
149peptidyl-arginine methylation (GO:0018216)2.81200479
150peptidyl-arginine N-methylation (GO:0035246)2.81200479
151chaperone-mediated protein transport (GO:0072321)2.79865128
152protein-cofactor linkage (GO:0018065)2.79025999
153maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.78967422
154pteridine-containing compound biosynthetic process (GO:0042559)2.78484286
155regulation of gene silencing by miRNA (GO:0060964)2.77538198
156regulation of gene silencing by RNA (GO:0060966)2.77538198
157regulation of posttranscriptional gene silencing (GO:0060147)2.77538198
158transcription initiation from RNA polymerase I promoter (GO:0006361)2.77213548
159histone H2B ubiquitination (GO:0033523)2.75983698
160tRNA processing (GO:0008033)2.75483887
161regulation of helicase activity (GO:0051095)2.72678814
162polyamine metabolic process (GO:0006595)2.71079037
163nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.70288606
164establishment of protein localization to mitochondrial membrane (GO:0090151)2.68822367
165cullin deneddylation (GO:0010388)2.66743477
166mitochondrial respiratory chain complex assembly (GO:0033108)2.66189364
167negative regulation of DNA recombination (GO:0045910)2.63999245
168ribonucleoprotein complex disassembly (GO:0032988)2.63915768
169regulation of DNA endoreduplication (GO:0032875)2.60919673
170establishment of viral latency (GO:0019043)2.59707519
171protein complex biogenesis (GO:0070271)2.58650748
172negative regulation of DNA-dependent DNA replication (GO:2000104)2.58613608
173auditory behavior (GO:0031223)2.57465957
174rRNA methylation (GO:0031167)2.57268949
175spinal cord development (GO:0021510)2.57182878
176centriole replication (GO:0007099)2.55267050
177tRNA metabolic process (GO:0006399)2.54334118

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.98769317
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.30661619
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.11833367
4E2F4_17652178_ChIP-ChIP_JURKAT_Human4.02094875
5MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.43853452
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.42608146
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.40228835
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.38479292
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.18446835
10EST1_17652178_ChIP-ChIP_JURKAT_Human3.16267163
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.99233554
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.96947735
13MYC_19079543_ChIP-ChIP_MESCs_Mouse2.91671471
14MYC_18358816_ChIP-ChIP_MESCs_Mouse2.90904637
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.86170628
16MYC_19030024_ChIP-ChIP_MESCs_Mouse2.82940780
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.71525265
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.38969223
19VDR_23849224_ChIP-Seq_CD4+_Human2.37346859
20XRN2_22483619_ChIP-Seq_HELA_Human2.36908949
21POU5F1_16153702_ChIP-ChIP_HESCs_Human2.34557007
22NELFA_20434984_ChIP-Seq_ESCs_Mouse2.31536756
23ZNF274_21170338_ChIP-Seq_K562_Hela2.31320959
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.27245051
25EWS_26573619_Chip-Seq_HEK293_Human2.24324573
26AR_21909140_ChIP-Seq_LNCAP_Human2.17005128
27FOXP3_21729870_ChIP-Seq_TREG_Human2.13776138
28CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.12410169
29ELF1_17652178_ChIP-ChIP_JURKAT_Human2.07886143
30DCP1A_22483619_ChIP-Seq_HELA_Human2.07853144
31E2F1_21310950_ChIP-Seq_MCF-7_Human2.06405101
32SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.03018348
33E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.00703703
34MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.00255300
35HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.99192856
36MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.98563284
37MYCN_18555785_ChIP-Seq_MESCs_Mouse1.93820865
38IGF1R_20145208_ChIP-Seq_DFB_Human1.93453421
39TTF2_22483619_ChIP-Seq_HELA_Human1.93324549
40NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.93230265
41GABP_19822575_ChIP-Seq_HepG2_Human1.92331227
42E2F1_18555785_ChIP-Seq_MESCs_Mouse1.88682733
43SOX2_16153702_ChIP-ChIP_HESCs_Human1.87287933
44TAF15_26573619_Chip-Seq_HEK293_Human1.83892256
45VDR_22108803_ChIP-Seq_LS180_Human1.78176893
46PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.77409484
47FUS_26573619_Chip-Seq_HEK293_Human1.77325813
48SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.75762478
49FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.71402649
50THAP11_20581084_ChIP-Seq_MESCs_Mouse1.71292645
51NANOG_16153702_ChIP-ChIP_HESCs_Human1.68119234
52ELK1_19687146_ChIP-ChIP_HELA_Human1.67193284
53KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.63102334
54POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.61675968
55YY1_21170310_ChIP-Seq_MESCs_Mouse1.59501003
56YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.59169375
57TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.58259294
58NOTCH1_21737748_ChIP-Seq_TLL_Human1.57458053
59ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.56001525
60CIITA_25753668_ChIP-Seq_RAJI_Human1.51614103
61HOXB4_20404135_ChIP-ChIP_EML_Mouse1.50404870
62CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.47932424
63NANOG_18555785_ChIP-Seq_MESCs_Mouse1.47721095
64EGR1_19374776_ChIP-ChIP_THP-1_Human1.45231934
65ZFX_18555785_ChIP-Seq_MESCs_Mouse1.44144663
66CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.43446773
67POU3F2_20337985_ChIP-ChIP_501MEL_Human1.43435339
68TP63_19390658_ChIP-ChIP_HaCaT_Human1.43085189
69SRF_21415370_ChIP-Seq_HL-1_Mouse1.41893370
70KDM5A_27292631_Chip-Seq_BREAST_Human1.37400426
71BMI1_23680149_ChIP-Seq_NPCS_Mouse1.32523102
72SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.29677361
73NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.28959047
74ERG_20887958_ChIP-Seq_HPC-7_Mouse1.28945748
75FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.28397285
76HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.27985288
77E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.25997933
78ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.25613060
79P300_19829295_ChIP-Seq_ESCs_Human1.23539399
80CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.23149391
81PADI4_21655091_ChIP-ChIP_MCF-7_Human1.22609583
82RBPJ_22232070_ChIP-Seq_NCS_Mouse1.20990149
83CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.17636090
84CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.17497045
85MYC_22102868_ChIP-Seq_BL_Human1.16871123
86CTBP1_25329375_ChIP-Seq_LNCAP_Human1.15320728
87POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.14240910
88MYC_18940864_ChIP-ChIP_HL60_Human1.14239664
89RNF2_27304074_Chip-Seq_NSC_Mouse1.12582557
90TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12301339
91SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.08598721
92MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.07295334
93ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.04212176
94KLF4_18555785_ChIP-Seq_MESCs_Mouse1.03942188
95DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.03372785
96GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.03312077
97PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.02696268
98CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.02235671
99KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.02007220
100KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.02007220
101KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.02007220
102KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.01585966
103SOX2_18555785_ChIP-Seq_MESCs_Mouse1.01154580
104TP53_22573176_ChIP-Seq_HFKS_Human0.98673676
105CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.96353677
106EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.94957187
107ZFP57_27257070_Chip-Seq_ESCs_Mouse0.94191995
108TFEB_21752829_ChIP-Seq_HELA_Human0.93387723
109GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.92183850
110SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.91495744
111PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.89007071
112SPI1_23547873_ChIP-Seq_NB4_Human0.88559818
113STAT3_1855785_ChIP-Seq_MESCs_Mouse0.88537921
114CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.88342415
115TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.87926673
116BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.87609046
117GATA1_26923725_Chip-Seq_HPCs_Mouse0.86698894
118CTBP2_25329375_ChIP-Seq_LNCAP_Human0.82003333
119CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.81768283
120ELK1_22589737_ChIP-Seq_MCF10A_Human0.80795423
121NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.80675756
122UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.79859522
123SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.77846027
124HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.76501070
125SALL1_21062744_ChIP-ChIP_HESCs_Human0.76463942
126CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.76373683
127SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.76102087
128CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.75840408
129POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.72669765
130KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.71696157
131DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.70201777
132FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.70105910
133CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.70094834
134IRF1_19129219_ChIP-ChIP_H3396_Human0.69224091
135NANOG_21062744_ChIP-ChIP_HESCs_Human0.67065735
136TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.66000425

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.34575678
2MP0010094_abnormal_chromosome_stability4.96281841
3MP0003111_abnormal_nucleus_morphology4.63323673
4MP0008057_abnormal_DNA_replication4.27142897
5MP0004957_abnormal_blastocyst_morpholog4.26116414
6MP0003077_abnormal_cell_cycle4.09396568
7MP0001986_abnormal_taste_sensitivity4.03747968
8MP0008058_abnormal_DNA_repair3.82029942
9MP0008007_abnormal_cellular_replicative3.21205842
10MP0008877_abnormal_DNA_methylation2.90436913
11MP0002735_abnormal_chemical_nociception2.70065746
12MP0008932_abnormal_embryonic_tissue2.69936401
13MP0005187_abnormal_penis_morphology2.55819938
14MP0001968_abnormal_touch/_nociception2.48752580
15MP0002396_abnormal_hematopoietic_system2.37296857
16MP0003787_abnormal_imprinting2.26311091
17MP0001730_embryonic_growth_arrest2.16597963
18MP0003786_premature_aging2.13777264
19MP0000350_abnormal_cell_proliferation2.10729274
20MP0005646_abnormal_pituitary_gland1.89946005
21MP0003123_paternal_imprinting1.85571299
22MP0000490_abnormal_crypts_of1.76332596
23MP0002234_abnormal_pharynx_morphology1.76055086
24MP0009697_abnormal_copulation1.72468038
25MP0002210_abnormal_sex_determination1.70607726
26MP0001672_abnormal_embryogenesis/_devel1.65891049
27MP0005380_embryogenesis_phenotype1.65891049
28MP0004808_abnormal_hematopoietic_stem1.64228921
29MP0001929_abnormal_gametogenesis1.64011158
30MP0001697_abnormal_embryo_size1.62357969
31MP0006072_abnormal_retinal_apoptosis1.61886434
32MP0003718_maternal_effect1.59783760
33MP0003868_abnormal_feces_composition1.57412182
34MP0010307_abnormal_tumor_latency1.54938041
35MP0000313_abnormal_cell_death1.54615283
36MP0010352_gastrointestinal_tract_polyps1.50920372
37MP0005410_abnormal_fertilization1.48960847
38MP0005499_abnormal_olfactory_system1.48218025
39MP0005394_taste/olfaction_phenotype1.48218025
40MP0002080_prenatal_lethality1.45968929
41MP0003984_embryonic_growth_retardation1.45926198
42MP0001145_abnormal_male_reproductive1.44954438
43MP0003122_maternal_imprinting1.43810401
44MP0002088_abnormal_embryonic_growth/wei1.41692639
45MP0002736_abnormal_nociception_after1.40510859
46MP0002019_abnormal_tumor_incidence1.35226842
47MP0009333_abnormal_splenocyte_physiolog1.35127650
48MP0001188_hyperpigmentation1.35111763
49MP0002085_abnormal_embryonic_tissue1.35107646
50MP0009703_decreased_birth_body1.31814131
51MP0006292_abnormal_olfactory_placode1.31743592
52MP0008872_abnormal_physiological_respon1.29816446
53MP0005397_hematopoietic_system_phenotyp1.28327265
54MP0001545_abnormal_hematopoietic_system1.28327265
55MP0003890_abnormal_embryonic-extraembry1.27881610
56MP0001666_abnormal_nutrient_absorption1.27692678
57MP0002132_abnormal_respiratory_system1.26868579
58MP0005220_abnormal_exocrine_pancreas1.26172100
59MP0000653_abnormal_sex_gland1.25060808
60MP0005645_abnormal_hypothalamus_physiol1.24687013
61MP0003763_abnormal_thymus_physiology1.24657035
62MP0002084_abnormal_developmental_patter1.21795642
63MP0001293_anophthalmia1.21217177
64MP0002160_abnormal_reproductive_system1.20289486
65MP0002102_abnormal_ear_morphology1.20106791
66MP0002653_abnormal_ependyma_morphology1.18005682
67MP0000631_abnormal_neuroendocrine_gland1.17546723
68MP0000703_abnormal_thymus_morphology1.17107473
69MP0002233_abnormal_nose_morphology1.16919817
70MP0003315_abnormal_perineum_morphology1.16427654
71MP0003698_abnormal_male_reproductive1.15993598
72MP0005253_abnormal_eye_physiology1.15756743
73MP0002086_abnormal_extraembryonic_tissu1.12417606
74MP0002734_abnormal_mechanical_nocicepti1.12328189
75MP0002398_abnormal_bone_marrow1.09677349
76MP0003121_genomic_imprinting1.07418264
77MP0006276_abnormal_autonomic_nervous1.06793225
78MP0003567_abnormal_fetal_cardiomyocyte1.06708662
79MP0010030_abnormal_orbit_morphology1.05717672
80MP0002722_abnormal_immune_system1.03078119
81MP0003880_abnormal_central_pattern1.02110409
82MP0005174_abnormal_tail_pigmentation1.01877238
83MP0004197_abnormal_fetal_growth/weight/1.00077004
84MP0000689_abnormal_spleen_morphology0.99991134
85MP0004147_increased_porphyrin_level0.99572296
86MP0000427_abnormal_hair_cycle0.99409872
87MP0002095_abnormal_skin_pigmentation0.97739678
88MP0005647_abnormal_sex_gland0.96800774
89MP0001764_abnormal_homeostasis0.96170488
90MP0002751_abnormal_autonomic_nervous0.95390827
91MP0006054_spinal_hemorrhage0.93770430
92MP0001529_abnormal_vocalization0.93198934
93MP0005389_reproductive_system_phenotype0.92547894
94MP0000358_abnormal_cell_content/0.92499424
95MP0001661_extended_life_span0.91924355
96MP0009379_abnormal_foot_pigmentation0.91439295
97MP0005075_abnormal_melanosome_morpholog0.90820569
98MP0000647_abnormal_sebaceous_gland0.90222384
99MP0002697_abnormal_eye_size0.89457962
100MP0001119_abnormal_female_reproductive0.89274572
101MP0000762_abnormal_tongue_morphology0.85990486
102MP0002429_abnormal_blood_cell0.85804319
103MP0003195_calcinosis0.85732520
104MP0008789_abnormal_olfactory_epithelium0.83821147
105MP0002733_abnormal_thermal_nociception0.82990097
106MP0003861_abnormal_nervous_system0.82984425
107MP0000015_abnormal_ear_pigmentation0.82751715
108MP0005386_behavior/neurological_phenoty0.82159089
109MP0004924_abnormal_behavior0.82159089
110MP0002822_catalepsy0.82077295
111MP0004145_abnormal_muscle_electrophysio0.81837546
112MP0003186_abnormal_redox_activity0.81657866
113MP0001324_abnormal_eye_pigmentation0.80546853
114MP0006036_abnormal_mitochondrial_physio0.77865834
115MP0003755_abnormal_palate_morphology0.77566217
116MP0002161_abnormal_fertility/fecundity0.77369769
117MP0000858_altered_metastatic_potential0.77333453
118MP0003937_abnormal_limbs/digits/tail_de0.76194491
119MP0005551_abnormal_eye_electrophysiolog0.75935280
120MP0005384_cellular_phenotype0.75909530
121MP0002163_abnormal_gland_morphology0.75511490
122MP0006035_abnormal_mitochondrial_morpho0.75165480
123MP0008995_early_reproductive_senescence0.74822108
124MP0005367_renal/urinary_system_phenotyp0.74733462
125MP0000516_abnormal_urinary_system0.74733462
126MP0003119_abnormal_digestive_system0.74005200
127MP0008260_abnormal_autophagy0.73988262
128MP0005391_vision/eye_phenotype0.72776032
129MP0000716_abnormal_immune_system0.72471052
130MP0002557_abnormal_social/conspecific_i0.72149136
131MP0002069_abnormal_eating/drinking_beha0.71270999
132MP0002938_white_spotting0.69818635
133MP0001299_abnormal_eye_distance/0.68367896
134MP0009053_abnormal_anal_canal0.67951912
135MP0005621_abnormal_cell_physiology0.64450365
136MP0003656_abnormal_erythrocyte_physiolo0.63546128
137MP0003941_abnormal_skin_development0.62391559
138MP0002111_abnormal_tail_morphology0.62079544
139MP0009672_abnormal_birth_weight0.61659604
140MP0001919_abnormal_reproductive_system0.61658673
141MP0002075_abnormal_coat/hair_pigmentati0.60274923
142MP0002092_abnormal_eye_morphology0.59391249
143MP0001286_abnormal_eye_development0.57029486
144MP0000049_abnormal_middle_ear0.56764268
145MP0005076_abnormal_cell_differentiation0.55609731
146MP0003221_abnormal_cardiomyocyte_apopto0.54597495
147MP0009278_abnormal_bone_marrow0.54511851
148MP0000432_abnormal_head_morphology0.52026742
149MP0001186_pigmentation_phenotype0.50938299
150MP0004133_heterotaxia0.50510553
151MP0000477_abnormal_intestine_morphology0.50175753
152MP0002420_abnormal_adaptive_immunity0.49579190

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of pyruvate family amino acid metabolism (HP:0010915)5.72274897
2Abnormality of alanine metabolism (HP:0010916)5.72274897
3Hyperalaninemia (HP:0003348)5.72274897
4Birth length less than 3rd percentile (HP:0003561)5.71649223
5Reticulocytopenia (HP:0001896)4.27014154
6Breast hypoplasia (HP:0003187)4.23099313
7Gonadotropin excess (HP:0000837)4.04870190
8Chromsome breakage (HP:0040012)3.93743314
9Chromosomal breakage induced by crosslinking agents (HP:0003221)3.91501253
10Protruding tongue (HP:0010808)3.76388094
11Abnormality of cells of the erythroid lineage (HP:0012130)3.71597282
12Abnormal number of erythroid precursors (HP:0012131)3.54797309
13Abnormality of the preputium (HP:0100587)3.39302229
14Meckel diverticulum (HP:0002245)3.33060284
15Patellar aplasia (HP:0006443)3.32075164
16Oral leukoplakia (HP:0002745)3.26587173
17Aplastic anemia (HP:0001915)3.25515345
18Abnormality of chromosome stability (HP:0003220)3.24238099
19Abnormality of the ileum (HP:0001549)3.18439515
20Degeneration of anterior horn cells (HP:0002398)3.13549183
21Abnormality of the anterior horn cell (HP:0006802)3.13549183
22Aplasia/Hypoplasia of the patella (HP:0006498)3.12750206
23Aplasia/Hypoplasia of the uvula (HP:0010293)3.11989710
24Abnormality of serum amino acid levels (HP:0003112)3.04829142
25Colon cancer (HP:0003003)3.03464006
26Impulsivity (HP:0100710)2.92709783
27Pallor (HP:0000980)2.92621938
28Absent thumb (HP:0009777)2.92261783
29Abnormality of the labia minora (HP:0012880)2.92035536
30Macrocytic anemia (HP:0001972)2.90466935
31Rough bone trabeculation (HP:0100670)2.90207113
32Cerebral hypomyelination (HP:0006808)2.85038677
33True hermaphroditism (HP:0010459)2.81491279
34Microretrognathia (HP:0000308)2.80197489
35Myelodysplasia (HP:0002863)2.79489590
36Carpal bone hypoplasia (HP:0001498)2.78035151
37Small intestinal stenosis (HP:0012848)2.73170241
38Duodenal stenosis (HP:0100867)2.73170241
39Volvulus (HP:0002580)2.71181295
40Increased serum pyruvate (HP:0003542)2.68705836
41Hyperglycinemia (HP:0002154)2.66441418
42Bone marrow hypocellularity (HP:0005528)2.65111179
43Broad-based gait (HP:0002136)2.63006894
44Medulloblastoma (HP:0002885)2.62834310
45Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.61353796
46Pancreatic fibrosis (HP:0100732)2.58542352
47Supernumerary spleens (HP:0009799)2.55172571
48Premature graying of hair (HP:0002216)2.51821234
49Enlarged penis (HP:0000040)2.51432433
50Selective tooth agenesis (HP:0001592)2.49878703
5111 pairs of ribs (HP:0000878)2.48079373
52Hypoplasia of the capital femoral epiphysis (HP:0003090)2.46807377
53Duplicated collecting system (HP:0000081)2.40832091
54Sloping forehead (HP:0000340)2.40613841
55Neoplasm of the pancreas (HP:0002894)2.39528428
56Ectopic kidney (HP:0000086)2.39156297
57Triphalangeal thumb (HP:0001199)2.37906702
58Abnormality of the heme biosynthetic pathway (HP:0010472)2.36649918
59Abnormal lung lobation (HP:0002101)2.34593592
60Abnormal spermatogenesis (HP:0008669)2.34077424
61Drooling (HP:0002307)2.32755726
62Congenital sensorineural hearing impairment (HP:0008527)2.32461321
63Absent radius (HP:0003974)2.31817200
64Cortical dysplasia (HP:0002539)2.27965272
65Abnormality of glycolysis (HP:0004366)2.24650515
66Abnormal umbilical cord blood vessels (HP:0011403)2.22516187
67Single umbilical artery (HP:0001195)2.22516187
68Abnormality of the fetal cardiovascular system (HP:0010948)2.22516187
69Pendular nystagmus (HP:0012043)2.22291866
70Abnormality of the duodenum (HP:0002246)2.21337847
71Aplasia/Hypoplasia of the sacrum (HP:0008517)2.19562946
72Secondary amenorrhea (HP:0000869)2.19497063
73Tracheoesophageal fistula (HP:0002575)2.18913587
74Pancytopenia (HP:0001876)2.18395554
75Abnormality of the carotid arteries (HP:0005344)2.17470682
76Abnormality of DNA repair (HP:0003254)2.17445438
77Cellular immunodeficiency (HP:0005374)2.14856386
78Absent forearm bone (HP:0003953)2.13348840
79Aplasia involving forearm bones (HP:0009822)2.13348840
80Aplasia/Hypoplasia of the tibia (HP:0005772)2.11598059
81Constricted visual fields (HP:0001133)2.10953603
82Abnormality of the renal collecting system (HP:0004742)2.09790510
83Cleft eyelid (HP:0000625)2.09265952
84Anencephaly (HP:0002323)2.08861589
85Atresia of the external auditory canal (HP:0000413)2.06633986
86Small hand (HP:0200055)2.05794837
87Excessive salivation (HP:0003781)2.05609491
88Abnormal trabecular bone morphology (HP:0100671)2.05489737
89Horseshoe kidney (HP:0000085)2.05478302
90Abnormality of serine family amino acid metabolism (HP:0010894)2.01584653
91Abnormality of glycine metabolism (HP:0010895)2.01584653
92Clubbing of toes (HP:0100760)2.01323273
93Decreased testicular size (HP:0008734)1.99280235
94Decreased electroretinogram (ERG) amplitude (HP:0000654)1.98254344
95Hyperventilation (HP:0002883)1.97715197
96Bilateral microphthalmos (HP:0007633)1.97428114
97Abnormality of homocysteine metabolism (HP:0010919)1.97193198
98Homocystinuria (HP:0002156)1.97193198
99Scrotal hypoplasia (HP:0000046)1.97149868
100Genital tract atresia (HP:0001827)1.96646878
101Acute encephalopathy (HP:0006846)1.95804202
102Vaginal atresia (HP:0000148)1.94302457
103Methylmalonic acidemia (HP:0002912)1.94265587
104Squamous cell carcinoma (HP:0002860)1.94261147
105Increased nuchal translucency (HP:0010880)1.94219735
106Slender long bone (HP:0003100)1.94124741
107Preaxial hand polydactyly (HP:0001177)1.92672003
108Microvesicular hepatic steatosis (HP:0001414)1.92642166
109Agnosia (HP:0010524)1.92440111
110Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.91707072
111Congenital primary aphakia (HP:0007707)1.91670586
112Acute necrotizing encephalopathy (HP:0006965)1.90899907
113Premature ovarian failure (HP:0008209)1.90003502
114Thrombocytosis (HP:0001894)1.89790584
115Chronic hepatic failure (HP:0100626)1.89676463
116Hyperglycinuria (HP:0003108)1.89245222
117Male pseudohermaphroditism (HP:0000037)1.89221373
118Aplasia/Hypoplasia of the sternum (HP:0006714)1.88870741
119Medial flaring of the eyebrow (HP:0010747)1.88760440
120Overlapping toe (HP:0001845)1.88692292
121Maternal diabetes (HP:0009800)1.88242026
122Anophthalmia (HP:0000528)1.87502459
123Absent epiphyses (HP:0010577)1.87053501
124Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.87053501
125Chronic bronchitis (HP:0004469)1.86407699
126Trismus (HP:0000211)1.86168667
127Short thumb (HP:0009778)1.84945098
128Asplenia (HP:0001746)1.83931708
129Neonatal onset (HP:0003623)1.83613542
130Rhinitis (HP:0012384)1.83516354
131Dynein arm defect of respiratory motile cilia (HP:0012255)1.83082251
132Absent/shortened dynein arms (HP:0200106)1.83082251
133Lymphoma (HP:0002665)1.82997734
134Nephrogenic diabetes insipidus (HP:0009806)1.82941293
135Clumsiness (HP:0002312)1.81666202
136Lipid accumulation in hepatocytes (HP:0006561)1.80077374
137Gait imbalance (HP:0002141)1.79999650
138Molar tooth sign on MRI (HP:0002419)1.79891181
139Abnormality of midbrain morphology (HP:0002418)1.79891181
140Nephroblastoma (Wilms tumor) (HP:0002667)1.79533001
141Exotropia (HP:0000577)1.78050968
142Rhabdomyosarcoma (HP:0002859)1.77626583
143Increased CSF lactate (HP:0002490)1.77197167
144Abnormal mitochondria in muscle tissue (HP:0008316)1.77005972
145Hypergonadotropic hypogonadism (HP:0000815)1.76939777
146Facial cleft (HP:0002006)1.75836519
147Hypoplasia of the radius (HP:0002984)1.74826652
148Intestinal atresia (HP:0011100)1.74635604
149Tubulointerstitial nephritis (HP:0001970)1.74443735
150Ureteral duplication (HP:0000073)1.73273995
151Abolished electroretinogram (ERG) (HP:0000550)1.72903196
152Hepatocellular necrosis (HP:0001404)1.72288929
153Median cleft lip (HP:0000161)1.71954821
154Lactic acidosis (HP:0003128)1.71730155
155Breast aplasia (HP:0100783)1.71004651
156Sclerocornea (HP:0000647)1.70321709
157Abnormal respiratory motile cilium physiology (HP:0012261)1.70149415
158Progressive microcephaly (HP:0000253)1.70134215
159Pancreatic cysts (HP:0001737)1.70098007
160Muscle fiber atrophy (HP:0100295)1.69568068
161Postnatal microcephaly (HP:0005484)1.68888418
162Abnormal number of incisors (HP:0011064)1.67622677
163Neoplasm of the colon (HP:0100273)1.67438584
164Type I transferrin isoform profile (HP:0003642)1.67313511
165Stenosis of the external auditory canal (HP:0000402)1.67183148
166Ependymoma (HP:0002888)1.66539714
167Septo-optic dysplasia (HP:0100842)1.66441886
168Petechiae (HP:0000967)1.66351434
169Acute lymphatic leukemia (HP:0006721)1.66332609
170Aplasia/Hypoplasia of the breasts (HP:0010311)1.65668701
171Short tibia (HP:0005736)1.65459707
172Sparse lateral eyebrow (HP:0005338)1.65258950
173Aplasia/Hypoplasia of the spleen (HP:0010451)1.65043275
174Mitochondrial inheritance (HP:0001427)1.64572816
175Increased serum lactate (HP:0002151)1.64272842

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK5.70523330
2BUB14.79184128
3WEE14.57721517
4CDC74.46462214
5INSRR3.84666197
6EIF2AK13.42726418
7PLK43.00254624
8NEK22.86758586
9SRPK12.80012119
10TRIM282.68530572
11NME22.68239872
12STK162.64239238
13BRSK22.43174820
14ACVR1B2.14043293
15WNK32.12920772
16VRK22.08555000
17MKNK12.05542717
18TLK12.05108264
19TTK2.04244011
20VRK12.02118818
21MAP4K22.00446554
22PLK11.99989338
23DYRK31.86365579
24RPS6KA41.82997625
25TSSK61.79183595
26MAP2K71.78950573
27MAP3K41.76871962
28MKNK21.67766307
29CDK71.67026710
30ATR1.62498673
31ZAK1.60777216
32AURKB1.60671353
33CCNB11.60651242
34EIF2AK31.60249707
35BRSK11.55857573
36PASK1.54154187
37PLK31.52982550
38CHEK21.47230008
39BCKDK1.39073193
40BMPR1B1.38135887
41NUAK11.37653284
42PDK41.35328198
43PDK31.35328198
44AURKA1.33657890
45PLK21.28507463
46BCR1.28212909
47TESK21.25469805
48TNIK1.16746253
49CHEK11.15127774
50CDK41.13169009
51TIE11.12121479
52GRK11.11292328
53CDK121.09412402
54ADRBK21.07001609
55CDK81.06375868
56MST41.04820637
57STK41.03143197
58RPS6KB21.02294618
59EIF2AK21.00972322
60MAP3K81.00704458
61STK100.98224399
62NEK10.90227358
63CSNK1G10.86855130
64CSNK1G30.86756636
65TGFBR10.86608628
66DAPK10.85125277
67CSNK1G20.84742208
68ATM0.84360546
69PBK0.83126590
70BRD40.79716842
71CDK90.79490540
72PINK10.78996564
73PDK20.77247193
74PAK40.76842998
75MAP4K10.75711275
76EPHA20.74367128
77CDK20.74006077
78CDK190.73118250
79CSNK2A10.71975461
80STK30.71948964
81FRK0.70944924
82PRKCE0.69920263
83PIM10.67606257
84YES10.67047808
85MAP3K50.66687481
86RPS6KA50.66306157
87MELK0.64674231
88CSNK2A20.63900435
89MAP3K100.62528762
90BLK0.62527629
91TEC0.61814005
92TESK10.60986331
93ERBB30.60957256
94TAF10.60333420
95FLT30.58904264
96PIM20.58874456
97FGR0.57862625
98CLK10.57725676
99CDK10.56689590
100MAPK150.56447364
101SGK4940.56334101
102SGK2230.56334101
103PAK10.56202094
104IRAK40.56086566
105KDR0.53041108
106SGK20.52379687
107CSNK1A1L0.51817936
108PNCK0.46204518
109MAP2K30.45719827
110EEF2K0.44452916
111SCYL20.44136409
112DYRK20.42807717
113IRAK30.42035192
114BTK0.38986872
115CSNK1A10.38971002
116MAP3K110.38296367
117STK38L0.38200992
118RPS6KB10.38171775
119PRKCG0.37577896
120CDK60.37348476
121CAMK2B0.37342422
122UHMK10.37264172
123MARK10.35638196
124PTK60.32932384
125NLK0.32857026
126ZAP700.32826662
127BRAF0.32659861
128TXK0.32590699
129CAMK2A0.32261277
130ADRBK10.30270482
131PRKCI0.30062200
132MAPK130.29807596
133ICK0.28338056
134OXSR10.28156619
135GRK60.28011826
136NEK90.27740610
137KIT0.27722739
138TAOK20.25631005
139AKT20.23612229
140CSNK1E0.20917918
141LRRK20.20662935
142PRKDC0.20643643
143NME10.20441940
144MARK30.20308142
145LYN0.19125902
146ALK0.17404929
147AKT30.17342050
148MAPKAPK20.16725288

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.14364872
2Mismatch repair_Homo sapiens_hsa034304.28693841
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.60430418
4RNA polymerase_Homo sapiens_hsa030203.45771968
5Ribosome_Homo sapiens_hsa030103.44900213
6Homologous recombination_Homo sapiens_hsa034403.35528251
7Proteasome_Homo sapiens_hsa030503.28577282
8Spliceosome_Homo sapiens_hsa030403.23245762
9RNA transport_Homo sapiens_hsa030133.06039919
10Base excision repair_Homo sapiens_hsa034103.01817950
11Nucleotide excision repair_Homo sapiens_hsa034202.97786015
12Cell cycle_Homo sapiens_hsa041102.78126637
13Pyrimidine metabolism_Homo sapiens_hsa002402.72026396
14Fanconi anemia pathway_Homo sapiens_hsa034602.63807798
15Maturity onset diabetes of the young_Homo sapiens_hsa049502.53974375
16One carbon pool by folate_Homo sapiens_hsa006702.39198625
17Non-homologous end-joining_Homo sapiens_hsa034502.27161207
18Basal transcription factors_Homo sapiens_hsa030222.20336501
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.17136368
20RNA degradation_Homo sapiens_hsa030181.83153264
212-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.75655625
22Steroid biosynthesis_Homo sapiens_hsa001001.71817861
23p53 signaling pathway_Homo sapiens_hsa041151.65114895
24mRNA surveillance pathway_Homo sapiens_hsa030151.62479643
25Propanoate metabolism_Homo sapiens_hsa006401.60535433
26Purine metabolism_Homo sapiens_hsa002301.54972246
27Fatty acid elongation_Homo sapiens_hsa000621.52383005
28Vitamin B6 metabolism_Homo sapiens_hsa007501.51451720
29Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.45219363
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.30850300
31Nicotine addiction_Homo sapiens_hsa050331.29293327
32Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.28583790
33Systemic lupus erythematosus_Homo sapiens_hsa053221.25997902
34Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.24901002
35Epstein-Barr virus infection_Homo sapiens_hsa051691.24556792
36Butanoate metabolism_Homo sapiens_hsa006501.16914580
37Pyruvate metabolism_Homo sapiens_hsa006201.04632088
38Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.04624279
39Peroxisome_Homo sapiens_hsa041461.04593200
40Folate biosynthesis_Homo sapiens_hsa007901.02958413
41Pentose phosphate pathway_Homo sapiens_hsa000300.95803112
42Herpes simplex infection_Homo sapiens_hsa051680.94830819
43Sulfur metabolism_Homo sapiens_hsa009200.93289661
44Oocyte meiosis_Homo sapiens_hsa041140.92010178
45Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.90178163
46Selenocompound metabolism_Homo sapiens_hsa004500.87876899
47Protein export_Homo sapiens_hsa030600.87070287
48Antigen processing and presentation_Homo sapiens_hsa046120.85820341
49Cysteine and methionine metabolism_Homo sapiens_hsa002700.83767389
50Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.83283586
51Viral carcinogenesis_Homo sapiens_hsa052030.83199961
52Taste transduction_Homo sapiens_hsa047420.79430532
53Phototransduction_Homo sapiens_hsa047440.79241535
54Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.75798476
55Sulfur relay system_Homo sapiens_hsa041220.71772786
56Huntingtons disease_Homo sapiens_hsa050160.71313168
57Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.70550489
58Alzheimers disease_Homo sapiens_hsa050100.70023968
59Fatty acid metabolism_Homo sapiens_hsa012120.68785925
60HTLV-I infection_Homo sapiens_hsa051660.67253596
61Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.67220630
62Arginine and proline metabolism_Homo sapiens_hsa003300.66573100
63Primary immunodeficiency_Homo sapiens_hsa053400.66440782
64Drug metabolism - other enzymes_Homo sapiens_hsa009830.64324942
65Collecting duct acid secretion_Homo sapiens_hsa049660.63038347
66Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.62846395
67Retinol metabolism_Homo sapiens_hsa008300.57974524
68Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.57962056
69alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.57284367
70beta-Alanine metabolism_Homo sapiens_hsa004100.56203737
71Starch and sucrose metabolism_Homo sapiens_hsa005000.55423296
72Glutathione metabolism_Homo sapiens_hsa004800.54241163
73Legionellosis_Homo sapiens_hsa051340.54054941
74Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.53864352
75Ether lipid metabolism_Homo sapiens_hsa005650.51682040
76Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.51380315
77Biosynthesis of amino acids_Homo sapiens_hsa012300.50688276
78Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.50448644
79Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.49388376
80Nitrogen metabolism_Homo sapiens_hsa009100.49135473
81Pentose and glucuronate interconversions_Homo sapiens_hsa000400.48729880
82Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.48118342
83Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.48079638
84Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.47332489
85Transcriptional misregulation in cancer_Homo sapiens_hsa052020.45932676
86Steroid hormone biosynthesis_Homo sapiens_hsa001400.45842617
87Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.44137829
88GABAergic synapse_Homo sapiens_hsa047270.43418195
89MicroRNAs in cancer_Homo sapiens_hsa052060.43410383
90Measles_Homo sapiens_hsa051620.42581553
91N-Glycan biosynthesis_Homo sapiens_hsa005100.42236369
92Small cell lung cancer_Homo sapiens_hsa052220.42128095
93Alcoholism_Homo sapiens_hsa050340.40860541
94Cardiac muscle contraction_Homo sapiens_hsa042600.39975602
95Primary bile acid biosynthesis_Homo sapiens_hsa001200.39811167
96Arginine biosynthesis_Homo sapiens_hsa002200.39165040
97NF-kappa B signaling pathway_Homo sapiens_hsa040640.35861863
98Parkinsons disease_Homo sapiens_hsa050120.34824913
99Cyanoamino acid metabolism_Homo sapiens_hsa004600.34721609
100Fatty acid degradation_Homo sapiens_hsa000710.34413405
101Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.34290404
102Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.33909910
103Intestinal immune network for IgA production_Homo sapiens_hsa046720.33815215
104Chemical carcinogenesis_Homo sapiens_hsa052040.33422959
105Thyroid cancer_Homo sapiens_hsa052160.32798582
106Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.32786447
107Caffeine metabolism_Homo sapiens_hsa002320.32476984
108Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.31765186
109Apoptosis_Homo sapiens_hsa042100.31158552
110Basal cell carcinoma_Homo sapiens_hsa052170.30857543
111Metabolic pathways_Homo sapiens_hsa011000.29100438
112Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.28870825
113Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.28282466
114Hematopoietic cell lineage_Homo sapiens_hsa046400.27968877
115Regulation of autophagy_Homo sapiens_hsa041400.27552502
116Hepatitis B_Homo sapiens_hsa051610.27526596
117Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.26986538
118Arachidonic acid metabolism_Homo sapiens_hsa005900.26760016
119Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.25018736
120Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.22648874
121Influenza A_Homo sapiens_hsa051640.22310394
122Hippo signaling pathway_Homo sapiens_hsa043900.21168619
123Carbon metabolism_Homo sapiens_hsa012000.20720734
124TGF-beta signaling pathway_Homo sapiens_hsa043500.19337636
125NOD-like receptor signaling pathway_Homo sapiens_hsa046210.18682244
126Shigellosis_Homo sapiens_hsa051310.18642176
127Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.17529481
128RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.16588108
129Notch signaling pathway_Homo sapiens_hsa043300.16370935
130Fructose and mannose metabolism_Homo sapiens_hsa000510.15787565
131Pathways in cancer_Homo sapiens_hsa052000.14239151
132Oxidative phosphorylation_Homo sapiens_hsa001900.13780353
133Colorectal cancer_Homo sapiens_hsa052100.13357469
134HIF-1 signaling pathway_Homo sapiens_hsa040660.11902032
135Hedgehog signaling pathway_Homo sapiens_hsa043400.10873885
136Renin-angiotensin system_Homo sapiens_hsa046140.09541184
137Linoleic acid metabolism_Homo sapiens_hsa005910.07024213
138Prostate cancer_Homo sapiens_hsa052150.06982185
139Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.06564713
140Chronic myeloid leukemia_Homo sapiens_hsa052200.06520651
141Allograft rejection_Homo sapiens_hsa053300.05203072
142Vitamin digestion and absorption_Homo sapiens_hsa049770.04173498
143Wnt signaling pathway_Homo sapiens_hsa043100.03754165
144Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.03724143
145Viral myocarditis_Homo sapiens_hsa054160.01735772
146Jak-STAT signaling pathway_Homo sapiens_hsa046300.01728223

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