DNAAF5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is essential for the preassembly or stability of axonemal dynein arms, and is found only in organisms with motile cilia and flagella. Mutations in this gene are associated with primary ciliary dyskinesia-18, a disorder characterized by abnormalities of motile cilia. Alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to kinetochore (GO:0034501)4.52874714
2mitotic nuclear envelope disassembly (GO:0007077)4.45983764
3nuclear pore complex assembly (GO:0051292)4.38931121
4nuclear pore organization (GO:0006999)4.34063289
5mitotic metaphase plate congression (GO:0007080)4.24381101
6folic acid-containing compound biosynthetic process (GO:0009396)4.24001425
7nuclear envelope disassembly (GO:0051081)4.15376773
8membrane disassembly (GO:0030397)4.15376773
9protein localization to chromosome, centromeric region (GO:0071459)4.09115860
10mitotic chromosome condensation (GO:0007076)3.95185328
11regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.94703661
12mitotic sister chromatid segregation (GO:0000070)3.87654856
13regulation of spindle organization (GO:0090224)3.83441543
14DNA unwinding involved in DNA replication (GO:0006268)3.79891046
15DNA replication-dependent nucleosome organization (GO:0034723)3.77591134
16DNA replication-dependent nucleosome assembly (GO:0006335)3.77591134
17proline biosynthetic process (GO:0006561)3.64991368
18positive regulation of chromosome segregation (GO:0051984)3.64338182
19metaphase plate congression (GO:0051310)3.63951278
20DNA replication initiation (GO:0006270)3.60846937
21L-serine metabolic process (GO:0006563)3.59870812
22formation of translation preinitiation complex (GO:0001731)3.54624883
23establishment of integrated proviral latency (GO:0075713)3.54133683
24sister chromatid segregation (GO:0000819)3.48972712
25nucleobase biosynthetic process (GO:0046112)3.47898622
26cellular protein complex localization (GO:0034629)3.47833657
27heterochromatin organization (GO:0070828)3.46122474
28regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.43763897
29nuclear envelope organization (GO:0006998)3.43588697
30DNA replication checkpoint (GO:0000076)3.42550324
31ribosome assembly (GO:0042255)3.41660202
32IMP biosynthetic process (GO:0006188)3.35111532
33folic acid metabolic process (GO:0046655)3.34022919
34regulation of mitotic spindle organization (GO:0060236)3.31706822
35DNA strand elongation involved in DNA replication (GO:0006271)3.29931303
36pore complex assembly (GO:0046931)3.29606965
37establishment of chromosome localization (GO:0051303)3.21375889
38negative regulation of histone methylation (GO:0031061)3.20838700
39regulation of chromosome segregation (GO:0051983)3.20288472
40pre-miRNA processing (GO:0031054)3.19368787
41mitotic recombination (GO:0006312)3.17310551
42ribosome biogenesis (GO:0042254)3.15360765
43protein K6-linked ubiquitination (GO:0085020)3.15192822
44DNA strand elongation (GO:0022616)3.15184281
45protein localization to chromosome (GO:0034502)3.10639268
46negative regulation of chromosome segregation (GO:0051985)3.10465219
47histone H2A monoubiquitination (GO:0035518)3.09507115
48purine nucleobase biosynthetic process (GO:0009113)3.09087983
49regulation of sister chromatid cohesion (GO:0007063)3.08954225
50peptidyl-arginine omega-N-methylation (GO:0035247)3.04693312
51attachment of spindle microtubules to kinetochore (GO:0008608)3.04545799
52negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.02928855
53IMP metabolic process (GO:0046040)3.02849628
54negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.02520565
55maturation of SSU-rRNA (GO:0030490)2.99305434
56chromatin assembly (GO:0031497)2.98536626
57regulation of translational fidelity (GO:0006450)2.98136852
58negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.97488621
59negative regulation of sister chromatid segregation (GO:0033046)2.97488621
60negative regulation of mitotic sister chromatid separation (GO:2000816)2.97488621
61negative regulation of mitotic sister chromatid segregation (GO:0033048)2.97488621
62ribosomal small subunit biogenesis (GO:0042274)2.97070636
63regulation of RNA export from nucleus (GO:0046831)2.96877450
64mitotic sister chromatid cohesion (GO:0007064)2.96687517
65positive regulation of mitotic sister chromatid separation (GO:1901970)2.96309242
66positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.96309242
67positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.96309242
68spindle checkpoint (GO:0031577)2.94855476
69chromatin assembly or disassembly (GO:0006333)2.93255962
70DNA duplex unwinding (GO:0032508)2.92563133
71regulation of posttranscriptional gene silencing (GO:0060147)2.92539785
72regulation of gene silencing by miRNA (GO:0060964)2.92539785
73regulation of gene silencing by RNA (GO:0060966)2.92539785
74dosage compensation (GO:0007549)2.92502325
75regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.92460877
76mitotic spindle assembly checkpoint (GO:0007094)2.92329381
77DNA geometric change (GO:0032392)2.91067902
78mitotic spindle checkpoint (GO:0071174)2.90178695
79spindle assembly checkpoint (GO:0071173)2.90168729
80regulation of mitotic metaphase/anaphase transition (GO:0030071)2.88365207
81viral mRNA export from host cell nucleus (GO:0046784)2.85244436
82regulation of histone H3-K9 methylation (GO:0051570)2.84915374
83DNA replication-independent nucleosome assembly (GO:0006336)2.84449947
84DNA replication-independent nucleosome organization (GO:0034724)2.84449947
85regulation of centrosome cycle (GO:0046605)2.83784913
86rRNA transcription (GO:0009303)2.83295493
87DNA packaging (GO:0006323)2.80631108
88nucleobase-containing small molecule interconversion (GO:0015949)2.77854261
89telomere maintenance via semi-conservative replication (GO:0032201)2.77460812
90regulation of mammary gland epithelial cell proliferation (GO:0033599)2.76982557
91regulation of translational termination (GO:0006449)2.74924729
92meiotic chromosome segregation (GO:0045132)2.74592301
93DNA damage response, signal transduction resulting in transcription (GO:0042772)2.73736674
94regulation of sister chromatid segregation (GO:0033045)2.73655902
95regulation of mitotic sister chromatid separation (GO:0010965)2.73655902
96regulation of mitotic sister chromatid segregation (GO:0033047)2.73655902
97pseudouridine synthesis (GO:0001522)2.73423706
98telomere maintenance via telomere lengthening (GO:0010833)2.72603602
99histone arginine methylation (GO:0034969)2.72439659
100negative regulation of mRNA processing (GO:0050686)2.72369812
101negative regulation of mRNA metabolic process (GO:1903312)2.71901733
102chromosome condensation (GO:0030261)2.71698800
103DNA topological change (GO:0006265)2.71176367
104ribosomal large subunit biogenesis (GO:0042273)2.70277216
105chromatin remodeling at centromere (GO:0031055)2.70205601
106mitochondrial RNA metabolic process (GO:0000959)2.69719082
107tetrahydrofolate metabolic process (GO:0046653)2.69460340
108DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.69284944
109chromosome segregation (GO:0007059)2.68709994
110gene silencing by RNA (GO:0031047)2.68538014
111kinetochore organization (GO:0051383)2.67599584
112histone H4-K12 acetylation (GO:0043983)2.66385544
113CENP-A containing nucleosome assembly (GO:0034080)2.63780301
114DNA conformation change (GO:0071103)2.62228377
115inner cell mass cell proliferation (GO:0001833)2.61764295
116positive regulation of DNA-dependent DNA replication (GO:2000105)2.61595660
117base-excision repair (GO:0006284)2.61446036
118protein complex localization (GO:0031503)2.60409211
119transcription from mitochondrial promoter (GO:0006390)2.60270033
120establishment of viral latency (GO:0019043)2.59803891
121peptidyl-arginine methylation (GO:0018216)2.58333804
122peptidyl-arginine N-methylation (GO:0035246)2.58333804
123ribonucleoprotein complex biogenesis (GO:0022613)2.57361797
124pteridine-containing compound biosynthetic process (GO:0042559)2.57357502
125proteasome assembly (GO:0043248)2.57262228
126nucleotide-excision repair, DNA gap filling (GO:0006297)2.55928502
127mRNA transport (GO:0051028)2.55616204
128ATP-dependent chromatin remodeling (GO:0043044)2.55241992
129telomere maintenance via recombination (GO:0000722)2.54739573
130somatic hypermutation of immunoglobulin genes (GO:0016446)2.54221833
131serine family amino acid biosynthetic process (GO:0009070)2.53685526
132establishment of apical/basal cell polarity (GO:0035089)2.53386306
133homocysteine metabolic process (GO:0050667)2.52880943
134planar cell polarity pathway involved in neural tube closure (GO:0090179)2.50631993
135desmosome organization (GO:0002934)2.50366162
136spliceosomal tri-snRNP complex assembly (GO:0000244)2.50231190
137negative regulation of RNA splicing (GO:0033119)2.48880699
138regulation of translational elongation (GO:0006448)2.48728111
139pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.47803932

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.31505015
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.76148870
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.55300950
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.20221704
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.13031408
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.12120460
7MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.73780239
8MYC_19079543_ChIP-ChIP_MESCs_Mouse2.61977803
9MYC_22102868_ChIP-Seq_BL_Human2.40660696
10EGR1_19374776_ChIP-ChIP_THP-1_Human2.39092162
11MYC_19030024_ChIP-ChIP_MESCs_Mouse2.38802420
12MYC_18358816_ChIP-ChIP_MESCs_Mouse2.27694451
13AR_21909140_ChIP-Seq_LNCAP_Human2.11937612
14NELFA_20434984_ChIP-Seq_ESCs_Mouse2.05739796
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.01662940
16EST1_17652178_ChIP-ChIP_JURKAT_Human1.97847348
17XRN2_22483619_ChIP-Seq_HELA_Human1.96215808
18JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.89709322
19E2F1_21310950_ChIP-Seq_MCF-7_Human1.86856455
20NANOG_18555785_ChIP-Seq_MESCs_Mouse1.85793964
21CREB1_15753290_ChIP-ChIP_HEK293T_Human1.83488254
22MYCN_18555785_ChIP-Seq_MESCs_Mouse1.83238065
23GABP_17652178_ChIP-ChIP_JURKAT_Human1.77094239
24TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.76485452
25KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.73458635
26KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.72272656
27SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.71775536
28VDR_23849224_ChIP-Seq_CD4+_Human1.68238678
29MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.67969109
30POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.66276985
31CIITA_25753668_ChIP-Seq_RAJI_Human1.62808996
32STAT3_1855785_ChIP-Seq_MESCs_Mouse1.62390901
33ESR1_15608294_ChIP-ChIP_MCF-7_Human1.61728596
34CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.61663238
35POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.61504507
36GABP_19822575_ChIP-Seq_HepG2_Human1.60898528
37E2F1_18555785_ChIP-Seq_MESCs_Mouse1.60541167
38TP63_17297297_ChIP-ChIP_HaCaT_Human1.55388581
39DCP1A_22483619_ChIP-Seq_HELA_Human1.54277045
40FOXP3_21729870_ChIP-Seq_TREG_Human1.51569830
41KLF4_18555785_ChIP-Seq_MESCs_Mouse1.50077728
42KDM5A_27292631_Chip-Seq_BREAST_Human1.49250975
43VDR_21846776_ChIP-Seq_THP-1_Human1.46594303
44ZFX_18555785_ChIP-Seq_MESCs_Mouse1.44815506
45NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.44718801
46HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.44390843
47PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.41849526
48DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.41160805
49TTF2_22483619_ChIP-Seq_HELA_Human1.37374867
50SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.36813891
51CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.35951504
52TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.35191926
53PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.31058122
54RACK7_27058665_Chip-Seq_MCF-7_Human1.30656963
55PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.28954505
56ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.28760688
57TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.26812030
58TP63_19390658_ChIP-ChIP_HaCaT_Human1.25631312
59CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.24296267
60KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.23077013
61E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.21714276
62YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.19187918
63TFEB_21752829_ChIP-Seq_HELA_Human1.18530916
64CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.18421021
65THAP11_20581084_ChIP-Seq_MESCs_Mouse1.17607343
66NANOG_21062744_ChIP-ChIP_HESCs_Human1.17325687
67NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.17309932
68KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.17175270
69ELF1_17652178_ChIP-ChIP_JURKAT_Human1.17088544
70NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.17068477
71HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.16745210
72ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.13967142
73PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.13782562
74SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.12938495
75SALL1_21062744_ChIP-ChIP_HESCs_Human1.09415859
76E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.09277504
77KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.07984458
78YY1_21170310_ChIP-Seq_MESCs_Mouse1.07668055
79TCF3_18692474_ChIP-Seq_MEFs_Mouse1.07609193
80SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.06860565
81CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.05163288
82SOX2_18555785_ChIP-Seq_MESCs_Mouse1.05154730
83CHD1_26751641_Chip-Seq_LNCaP_Human1.03798836
84TCF7_22412390_ChIP-Seq_EML_Mouse1.03764314
85ZNF263_19887448_ChIP-Seq_K562_Human1.03348968
86TBX5_21415370_ChIP-Seq_HL-1_Mouse1.00908424
87ATF3_27146783_Chip-Seq_COLON_Human1.00091601
88KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.99739464
89KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.99739464
90KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.99739464
91FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.99553156
92LXR_22292898_ChIP-Seq_THP-1_Human0.99154375
93POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.98844763
94HOXB4_20404135_ChIP-ChIP_EML_Mouse0.98768921
95ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.97208998
96TET1_21451524_ChIP-Seq_MESCs_Mouse0.97020396
97SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.97003819
98UTX_26944678_Chip-Seq_JUKART_Human0.94067029
99TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.94033327
100BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.93782531
101TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.93685113
102ELK1_19687146_ChIP-ChIP_HELA_Human0.91901979
103SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.91554963
104TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.91529798
105ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.91489388
106ERG_20887958_ChIP-Seq_HPC-7_Mouse0.91156891
107NOTCH1_21737748_ChIP-Seq_TLL_Human0.91139442
108ELK3_25401928_ChIP-Seq_HUVEC_Human0.89978519
109CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.89668867
110ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.89301568
111NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.89063384
112KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.88464455
113CLOCK_20551151_ChIP-Seq_293T_Human0.88420500
114TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.88388097
115MAF_26560356_Chip-Seq_TH1_Human0.87747865
116TCF3_18692474_ChIP-Seq_MESCs_Mouse0.87608619
117MYB_26560356_Chip-Seq_TH1_Human0.86475236
118SOX17_20123909_ChIP-Seq_XEN_Mouse0.86470473
119FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.85929500
120SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.85895690
121DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.85073088
122FOXP1_21924763_ChIP-Seq_HESCs_Human0.84495391
123RARG_19884340_ChIP-ChIP_MEFs_Mouse0.84451655
124KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.84303502
125PADI4_21655091_ChIP-ChIP_MCF-7_Human0.84199012
126STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.83797630
127NCOR1_26117541_ChIP-Seq_K562_Human0.82697525

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.53719807
2MP0003111_abnormal_nucleus_morphology3.74466639
3MP0004957_abnormal_blastocyst_morpholog3.73040128
4MP0010094_abnormal_chromosome_stability3.60988376
5MP0003077_abnormal_cell_cycle3.41021274
6MP0008057_abnormal_DNA_replication3.12487797
7MP0001730_embryonic_growth_arrest2.39274358
8MP0010352_gastrointestinal_tract_polyps2.34764375
9MP0010234_abnormal_vibrissa_follicle2.28591954
10MP0008007_abnormal_cellular_replicative2.26118667
11MP0008058_abnormal_DNA_repair2.14130318
12MP0000350_abnormal_cell_proliferation2.14103745
13MP0002653_abnormal_ependyma_morphology1.99376574
14MP0008932_abnormal_embryonic_tissue1.96887012
15MP0008877_abnormal_DNA_methylation1.93476870
16MP0010307_abnormal_tumor_latency1.93294177
17MP0001672_abnormal_embryogenesis/_devel1.92009288
18MP0005380_embryogenesis_phenotype1.92009288
19MP0002396_abnormal_hematopoietic_system1.89911785
20MP0003705_abnormal_hypodermis_morpholog1.87163294
21MP0003123_paternal_imprinting1.86631574
22MP0003941_abnormal_skin_development1.83850514
23MP0005076_abnormal_cell_differentiation1.81468845
24MP0001697_abnormal_embryo_size1.80434792
25MP0003984_embryonic_growth_retardation1.76752669
26MP0002088_abnormal_embryonic_growth/wei1.72549612
27MP0002084_abnormal_developmental_patter1.71654454
28MP0002085_abnormal_embryonic_tissue1.71634925
29MP0003718_maternal_effect1.64192949
30MP0002080_prenatal_lethality1.58499841
31MP0002086_abnormal_extraembryonic_tissu1.58015895
32MP0000678_abnormal_parathyroid_gland1.55629967
33MP0000490_abnormal_crypts_of1.54539539
34MP0004197_abnormal_fetal_growth/weight/1.53437640
35MP0003786_premature_aging1.53028982
36MP0004808_abnormal_hematopoietic_stem1.52121394
37MP0000566_synostosis1.48525194
38MP0001545_abnormal_hematopoietic_system1.43382039
39MP0005397_hematopoietic_system_phenotyp1.43382039
40MP0002249_abnormal_larynx_morphology1.42362881
41MP0009278_abnormal_bone_marrow1.38840294
42MP0000762_abnormal_tongue_morphology1.35974428
43MP0010030_abnormal_orbit_morphology1.34411411
44MP0005501_abnormal_skin_physiology1.33968480
45MP0003566_abnormal_cell_adhesion1.32577467
46MP0002697_abnormal_eye_size1.32523475
47MP0002019_abnormal_tumor_incidence1.32334543
48MP0003942_abnormal_urinary_system1.31764064
49MP0005451_abnormal_body_composition1.31579993
50MP0001661_extended_life_span1.31126835
51MP0002796_impaired_skin_barrier1.30037403
52MP0003567_abnormal_fetal_cardiomyocyte1.29618316
53MP0000313_abnormal_cell_death1.28822105
54MP0002210_abnormal_sex_determination1.28797264
55MP0001929_abnormal_gametogenesis1.21240351
56MP0009697_abnormal_copulation1.20805240
57MP0000579_abnormal_nail_morphology1.20411285
58MP0001849_ear_inflammation1.19281327
59MP0009333_abnormal_splenocyte_physiolog1.16509243
60MP0005023_abnormal_wound_healing1.15963869
61MP0004272_abnormal_basement_membrane1.14457475
62MP0009379_abnormal_foot_pigmentation1.14398209
63MP0003806_abnormal_nucleotide_metabolis1.14106346
64MP0000733_abnormal_muscle_development1.13128850
65MP0005623_abnormal_meninges_morphology1.11866082
66MP0005257_abnormal_intraocular_pressure1.10581923
67MP0001346_abnormal_lacrimal_gland1.10539621
68MP0001145_abnormal_male_reproductive1.10077188
69MP0000467_abnormal_esophagus_morphology1.09919422
70MP0000049_abnormal_middle_ear1.09730676
71MP0001293_anophthalmia1.09056584
72MP0004264_abnormal_extraembryonic_tissu1.05139357
73MP0003763_abnormal_thymus_physiology1.05087019
74MP0002060_abnormal_skin_morphology1.04788531
75MP0000703_abnormal_thymus_morphology1.04417762
76MP0005670_abnormal_white_adipose1.03749616
77MP0000534_abnormal_ureter_morphology1.03714286
78MP0004858_abnormal_nervous_system1.03461716
79MP0003890_abnormal_embryonic-extraembry1.02645954
80MP0001915_intracranial_hemorrhage1.01374931
81MP0003119_abnormal_digestive_system1.00459252
82MP0000653_abnormal_sex_gland0.99031676
83MP0000750_abnormal_muscle_regeneration0.97975837
84MP0009672_abnormal_birth_weight0.96106557
85MP0002877_abnormal_melanocyte_morpholog0.93318281
86MP0002098_abnormal_vibrissa_morphology0.92286751
87MP0002938_white_spotting0.91299986
88MP0004185_abnormal_adipocyte_glucose0.90130695
89MP0002398_abnormal_bone_marrow0.88364730
90MP0003121_genomic_imprinting0.87647509
91MP0000751_myopathy0.87613092
92MP0002722_abnormal_immune_system0.87046206
93MP0005621_abnormal_cell_physiology0.86294385
94MP0003221_abnormal_cardiomyocyte_apopto0.85831598
95MP0009703_decreased_birth_body0.84818948
96MP0003755_abnormal_palate_morphology0.84744238
97MP0001286_abnormal_eye_development0.84344355
98MP0000689_abnormal_spleen_morphology0.84191318
99MP0009840_abnormal_foam_cell0.83772209
100MP0002269_muscular_atrophy0.83097177
101MP0000537_abnormal_urethra_morphology0.79685958
102MP0003646_muscle_fatigue0.79592191
103MP0005384_cellular_phenotype0.79009112
104MP0002092_abnormal_eye_morphology0.78444350
105MP0000428_abnormal_craniofacial_morphol0.77738150
106MP0010678_abnormal_skin_adnexa0.77620878
107MP0002925_abnormal_cardiovascular_devel0.77310917
108MP0003861_abnormal_nervous_system0.76794879
109MP0001881_abnormal_mammary_gland0.76649791
110MP0002160_abnormal_reproductive_system0.76587810
111MP0000358_abnormal_cell_content/0.76394407
112MP0003385_abnormal_body_wall0.76297218
113MP0002116_abnormal_craniofacial_bone0.76195626
114MP0002111_abnormal_tail_morphology0.76041172
115MP0001119_abnormal_female_reproductive0.74678046
116MP0000627_abnormal_mammary_gland0.74430366
117MP0003937_abnormal_limbs/digits/tail_de0.73895324
118MP0000858_altered_metastatic_potential0.73201297
119MP0004233_abnormal_muscle_weight0.72769276
120MP0001340_abnormal_eyelid_morphology0.72391285
121MP0002233_abnormal_nose_morphology0.71673603
122MP0000747_muscle_weakness0.71394884
123MP0000749_muscle_degeneration0.71251399
124MP0009053_abnormal_anal_canal0.70401189
125MP0010630_abnormal_cardiac_muscle0.70039026
126MP0004133_heterotaxia0.68412161
127MP0002132_abnormal_respiratory_system0.68161901
128MP0005395_other_phenotype0.67031748
129MP0003699_abnormal_female_reproductive0.66749960
130MP0004084_abnormal_cardiac_muscle0.66497093
131MP0000266_abnormal_heart_morphology0.66077037
132MP0000477_abnormal_intestine_morphology0.65937045
133MP0000432_abnormal_head_morphology0.63880119
134MP0002429_abnormal_blood_cell0.63841918
135MP0003315_abnormal_perineum_morphology0.62344758
136MP0003935_abnormal_craniofacial_develop0.61959177
137MP0003453_abnormal_keratinocyte_physiol0.58642283
138MP0002970_abnormal_white_adipose0.58490458
139MP0002161_abnormal_fertility/fecundity0.58184559
140MP0008770_decreased_survivor_rate0.57325019
141MP0003115_abnormal_respiratory_system0.55236977

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)3.56461546
2Ependymoma (HP:0002888)3.38726379
3Selective tooth agenesis (HP:0001592)3.25004512
4Aplasia/Hypoplasia of the sacrum (HP:0008517)3.22481324
5Breast hypoplasia (HP:0003187)3.20061238
6Patellar aplasia (HP:0006443)3.15278362
7Hyperacusis (HP:0010780)3.10073670
8Degeneration of anterior horn cells (HP:0002398)3.08954495
9Abnormality of the anterior horn cell (HP:0006802)3.08954495
10Carpal bone hypoplasia (HP:0001498)2.99704128
11Abnormality of the umbilical cord (HP:0010881)2.92996018
12Aplasia/Hypoplasia of the patella (HP:0006498)2.91231187
13Abnormality of the fetal cardiovascular system (HP:0010948)2.86416018
14Abnormal umbilical cord blood vessels (HP:0011403)2.86416018
15Single umbilical artery (HP:0001195)2.86416018
16Chromsome breakage (HP:0040012)2.69731459
17Impulsivity (HP:0100710)2.67055854
18Oral leukoplakia (HP:0002745)2.64629079
19Broad distal phalanx of finger (HP:0009836)2.60260200
20Medulloblastoma (HP:0002885)2.58493022
21Basal cell carcinoma (HP:0002671)2.57219793
22Abnormality of glycolysis (HP:0004366)2.55717786
23Rough bone trabeculation (HP:0100670)2.49387574
24Rhabdomyosarcoma (HP:0002859)2.48404235
25Facial hemangioma (HP:0000329)2.47650742
26Abnormality of chromosome stability (HP:0003220)2.47203332
27Insomnia (HP:0100785)2.45594302
28Chromosomal breakage induced by crosslinking agents (HP:0003221)2.45541221
29Ectopic kidney (HP:0000086)2.44860908
30Prominent nose (HP:0000448)2.42214873
31Septate vagina (HP:0001153)2.42064579
32Premature ovarian failure (HP:0008209)2.37493692
33Meckel diverticulum (HP:0002245)2.36173241
34Abnormality of the fingertips (HP:0001211)2.35114811
35Aplasia/Hypoplasia of the uvula (HP:0010293)2.34277996
36Absent thumb (HP:0009777)2.33719364
37Nasal polyposis (HP:0100582)2.33356126
38Abnormality of the ileum (HP:0001549)2.32579829
39Abnormality of the preputium (HP:0100587)2.32230498
40Myelodysplasia (HP:0002863)2.31280623
41Missing ribs (HP:0000921)2.27704721
42Colon cancer (HP:0003003)2.27480112
43Duplication of thumb phalanx (HP:0009942)2.27469438
44Secondary amenorrhea (HP:0000869)2.26710486
45Trismus (HP:0000211)2.26134042
46Neoplasm of the oral cavity (HP:0100649)2.25858986
47Absent radius (HP:0003974)2.25503080
48Rib fusion (HP:0000902)2.25484884
49Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.25017259
50Squamous cell carcinoma (HP:0002860)2.24167085
51Progressive muscle weakness (HP:0003323)2.22462748
52Deviation of the thumb (HP:0009603)2.22178049
53Metaphyseal cupping (HP:0003021)2.20550040
54Abnormalities of placenta or umbilical cord (HP:0001194)2.19252072
55Proximal placement of thumb (HP:0009623)2.17860974
56Male infertility (HP:0003251)2.15327442
57Neoplasm of the pancreas (HP:0002894)2.15076603
58Sparse lateral eyebrow (HP:0005338)2.14055212
59Long eyelashes (HP:0000527)2.13994433
60Multiple enchondromatosis (HP:0005701)2.13243078
61Neoplasm of striated muscle (HP:0009728)2.12657699
62Abnormality of the astrocytes (HP:0100707)2.12479664
63Astrocytoma (HP:0009592)2.12479664
64Cafe-au-lait spot (HP:0000957)2.12250267
65Abnormality of the calcaneus (HP:0008364)2.12194439
66Reticulocytopenia (HP:0001896)2.09995575
67Increased serum pyruvate (HP:0003542)2.08303881
68Overriding aorta (HP:0002623)2.08088285
6911 pairs of ribs (HP:0000878)2.07990762
70Myopathic facies (HP:0002058)2.07850137
71Aplasia/hypoplasia of the humerus (HP:0006507)2.07152967
72Absent forearm bone (HP:0003953)2.06649304
73Aplasia involving forearm bones (HP:0009822)2.06649304
74Diaphragmatic weakness (HP:0009113)2.06622416
75Duodenal stenosis (HP:0100867)2.06547734
76Small intestinal stenosis (HP:0012848)2.06547734
77Entropion (HP:0000621)2.06291467
78Spinal muscular atrophy (HP:0007269)2.05749815
79Abnormality of the distal phalanges of the toes (HP:0010182)2.04527310
80Facial cleft (HP:0002006)2.01364090
81Sloping forehead (HP:0000340)2.00936183
82Overlapping toe (HP:0001845)2.00492049
83Hypoplasia of the capital femoral epiphysis (HP:0003090)2.00379531
84Abnormality of the labia minora (HP:0012880)1.95853172
85Short humerus (HP:0005792)1.95529627
86Bone marrow hypocellularity (HP:0005528)1.93309392
87Ureteral duplication (HP:0000073)1.92287262
88Aplastic anemia (HP:0001915)1.91095481
89Cerebral hypomyelination (HP:0006808)1.90584351
90Increased nuchal translucency (HP:0010880)1.89442794
91Renal duplication (HP:0000075)1.87911154
92Abnormal number of erythroid precursors (HP:0012131)1.87749954
93Abnormality of the nasal mucosa (HP:0000433)1.86863760
94Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.86301050
95Absent epiphyses (HP:0010577)1.86301050
96Microvesicular hepatic steatosis (HP:0001414)1.84604208
97Microretrognathia (HP:0000308)1.84467725
98Glioma (HP:0009733)1.84320589
99Abnormality of the phalanges of the hallux (HP:0010057)1.83995299
100Ulnar bowing (HP:0003031)1.83378937
101Abnormal lung lobation (HP:0002101)1.82570199
102Premature rupture of membranes (HP:0001788)1.82392414
103Biliary tract neoplasm (HP:0100574)1.81873363
104Agnosia (HP:0010524)1.81597776
105Abnormality of abdominal situs (HP:0011620)1.81523904
106Abdominal situs inversus (HP:0003363)1.81523904
107Urethral obstruction (HP:0000796)1.81366724
108Abnormal number of incisors (HP:0011064)1.80998746
109Poikiloderma (HP:0001029)1.80902611
110Abnormality of cells of the erythroid lineage (HP:0012130)1.80806075
111Microglossia (HP:0000171)1.80623826
112High pitched voice (HP:0001620)1.79725244
113Elfin facies (HP:0004428)1.79058625
114Atresia of the external auditory canal (HP:0000413)1.77433833
115Abnormal trabecular bone morphology (HP:0100671)1.76409510
116Abnormality of cochlea (HP:0000375)1.76172364
117Long palpebral fissure (HP:0000637)1.75569408
118Ankle contracture (HP:0006466)1.75524171
119Nephroblastoma (Wilms tumor) (HP:0002667)1.75329156
120Pterygium (HP:0001059)1.75177710
121Stridor (HP:0010307)1.75149917
122Supernumerary spleens (HP:0009799)1.73039461
123Abnormality of the carotid arteries (HP:0005344)1.72593705
124Abnormality of the duodenum (HP:0002246)1.70796978
125Short nail (HP:0001799)1.70430858
126Tracheoesophageal fistula (HP:0002575)1.69596035
127Atrophy/Degeneration involving motor neurons (HP:0007373)1.69582229
128Progressive external ophthalmoplegia (HP:0000590)1.66986406
129Ankyloglossia (HP:0010296)1.66853147
130Choanal atresia (HP:0000453)1.65704440
131Shallow orbits (HP:0000586)1.65658219
132Difficulty climbing stairs (HP:0003551)1.65205273
133Shawl scrotum (HP:0000049)1.64781603
134Abnormality of reticulocytes (HP:0004312)1.64146507
135Malignant gastrointestinal tract tumors (HP:0006749)1.63659178
136Gastrointestinal carcinoma (HP:0002672)1.63659178
137High anterior hairline (HP:0009890)1.63175739
138Horseshoe kidney (HP:0000085)1.62516511
139Short thumb (HP:0009778)1.61918179
140Premature graying of hair (HP:0002216)1.61272405
141Broad palm (HP:0001169)1.61152982
142Distal lower limb amyotrophy (HP:0008944)1.61149630
143Thin ribs (HP:0000883)1.60781991
144Patellar dislocation (HP:0002999)1.59850155
145Biconcave vertebral bodies (HP:0004586)1.59483215
146Abnormal gallbladder physiology (HP:0012438)1.59301469
147Cholecystitis (HP:0001082)1.59301469
148Embryonal renal neoplasm (HP:0011794)1.59080036
149Disproportionate tall stature (HP:0001519)1.58933402
150Duplicated collecting system (HP:0000081)1.58534144
151Abnormality of the tricuspid valve (HP:0001702)1.56969717
152Preauricular skin tag (HP:0000384)1.54935031
153Reduced subcutaneous adipose tissue (HP:0003758)1.54893465
154Asymmetry of the thorax (HP:0001555)1.54856955
155Arteriovenous malformation (HP:0100026)1.54708226
156Ragged-red muscle fibers (HP:0003200)1.53042093
157Increased connective tissue (HP:0009025)1.52037971
158Upper limb amyotrophy (HP:0009129)1.51955345
159Distal upper limb amyotrophy (HP:0007149)1.51955345
160Achilles tendon contracture (HP:0001771)1.51867466

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SMG13.63047090
2BUB13.57658357
3WEE13.47602140
4CDC73.38873396
5CDK123.36237142
6NEK23.18995321
7EEF2K2.94583085
8MST1R2.54869345
9VRK22.45234971
10MAP3K102.39127897
11TTK2.37574372
12STK102.25934692
13IRAK32.16799998
14PLK41.98226631
15TRIB31.93682583
16PBK1.89603816
17SIK11.88366726
18EPHA21.86580942
19LATS11.85409609
20PLK11.74047824
21RPS6KB21.72495033
22BRSK21.72458710
23CDK71.71298359
24MET1.63873449
25EIF2AK11.63305728
26PKN21.60911269
27CDK41.60139713
28RPS6KA41.59208106
29NEK11.55657834
30TSSK61.53421233
31MAP3K81.52584090
32DYRK31.50482863
33CHEK21.45729307
34AURKB1.43751364
35LATS21.40191744
36TAF11.37686434
37STK38L1.37417629
38NME11.36019956
39STK31.34653519
40TESK21.30934487
41ATR1.30571036
42CHEK11.28380763
43ICK1.26409663
44PAK41.18518462
45PASK1.13768997
46ERBB41.12067738
47MTOR1.11499016
48MAP4K11.10029614
49BRSK11.08270555
50PTK21.08263916
51MAPKAPK31.06613693
52PIM11.05067276
53SRPK11.03758691
54STK41.03560301
55BRD41.02322759
56FLT31.01848682
57AURKA1.01447323
58MELK1.01222863
59NME21.00746085
60ACVR1B0.95493699
61TAOK10.90714551
62TTN0.90220547
63PNCK0.90022146
64SCYL20.89866544
65CDK60.89129666
66LRRK20.88630077
67STK160.86807903
68CDK20.83997900
69ALK0.83173624
70LMTK20.82279750
71ATM0.79298775
72PLK30.78211424
73EIF2AK30.75591622
74PRKD30.74596599
75ERN10.70653556
76PDK40.70302830
77PDK30.70302830
78MOS0.67422683
79PDGFRA0.66965290
80PTK60.66428434
81TGFBR10.65910028
82PAK10.65210182
83MKNK10.64267939
84PIM20.62913052
85ILK0.62389476
86PAK20.62038213
87JAK30.60016105
88CDK90.59961488
89ARAF0.57734110
90TESK10.56652135
91VRK10.55587039
92CDK10.52568397
93MKNK20.51340992
94AKT20.51340030
95MST40.50332165
96MAPK110.48950801
97MAP3K110.48518753
98MAP3K60.48197417
99MAP3K30.47262905
100TLK10.47062055
101EIF2AK20.47002978
102LIMK10.45870543
103GRK60.45414199
104FGFR40.43910944
105MAP2K30.43747237
106FGFR10.41063647
107DAPK10.40898411
108RPS6KA50.40386988
109ZAP700.39897524
110PRKCI0.39516100
111CLK10.37837048
112ZAK0.37835301
113CSNK2A20.37289317
114DYRK1B0.36957148
115BMX0.36734721
116CAMK1D0.36722779
117BRAF0.36418328
118CAMK1G0.35879685
119CHUK0.35294357
120RPS6KA10.35253915
121CDK80.33335514
122TYRO30.33286649
123DMPK0.32895466
124CSNK2A10.32573566
125PDK20.32166743
126NLK0.31466926
127KDR0.31246362
128MAPK10.31054112
129BTK0.30462029
130PRPF4B0.30406991
131CSNK1E0.28320062

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.73264297
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.43321123
3RNA transport_Homo sapiens_hsa030133.25851647
4Mismatch repair_Homo sapiens_hsa034303.17578452
5Cell cycle_Homo sapiens_hsa041102.98786767
6Spliceosome_Homo sapiens_hsa030402.74858855
7Base excision repair_Homo sapiens_hsa034102.64372839
8One carbon pool by folate_Homo sapiens_hsa006702.53141420
9RNA polymerase_Homo sapiens_hsa030202.48196743
10Homologous recombination_Homo sapiens_hsa034402.35911593
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.22691291
12Nucleotide excision repair_Homo sapiens_hsa034202.21435707
13p53 signaling pathway_Homo sapiens_hsa041151.95015069
14Fanconi anemia pathway_Homo sapiens_hsa034601.94219541
15RNA degradation_Homo sapiens_hsa030181.87315250
16Non-homologous end-joining_Homo sapiens_hsa034501.86505080
17Pyrimidine metabolism_Homo sapiens_hsa002401.85888139
18mRNA surveillance pathway_Homo sapiens_hsa030151.81892236
19Basal transcription factors_Homo sapiens_hsa030221.79719504
20Ribosome_Homo sapiens_hsa030101.72621712
21Folate biosynthesis_Homo sapiens_hsa007901.50629129
22Proteasome_Homo sapiens_hsa030501.49657969
23Vitamin B6 metabolism_Homo sapiens_hsa007501.45236111
24Pyruvate metabolism_Homo sapiens_hsa006201.33112004
25Pentose phosphate pathway_Homo sapiens_hsa000301.31688010
26Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.31312334
27Biosynthesis of amino acids_Homo sapiens_hsa012301.26388315
28Selenocompound metabolism_Homo sapiens_hsa004501.20713018
29Epstein-Barr virus infection_Homo sapiens_hsa051691.20119388
30Cysteine and methionine metabolism_Homo sapiens_hsa002701.19622620
31Viral carcinogenesis_Homo sapiens_hsa052031.16951321
32Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.16543179
33Antigen processing and presentation_Homo sapiens_hsa046121.13232923
34Notch signaling pathway_Homo sapiens_hsa043301.11035013
35Herpes simplex infection_Homo sapiens_hsa051681.09116116
36Galactose metabolism_Homo sapiens_hsa000521.04688557
37MicroRNAs in cancer_Homo sapiens_hsa052061.04349515
38HTLV-I infection_Homo sapiens_hsa051661.02705516
39N-Glycan biosynthesis_Homo sapiens_hsa005101.02600292
40Small cell lung cancer_Homo sapiens_hsa052221.02555318
41Oocyte meiosis_Homo sapiens_hsa041140.98172380
42Thyroid cancer_Homo sapiens_hsa052160.98060491
43Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.94835759
44Purine metabolism_Homo sapiens_hsa002300.90121245
45Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.88931028
46Arginine biosynthesis_Homo sapiens_hsa002200.85925806
47Lysine degradation_Homo sapiens_hsa003100.84958181
48Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.83399451
49Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.82698755
50Sulfur relay system_Homo sapiens_hsa041220.81502138
51Chronic myeloid leukemia_Homo sapiens_hsa052200.81253979
52Steroid biosynthesis_Homo sapiens_hsa001000.79966320
53Systemic lupus erythematosus_Homo sapiens_hsa053220.78599464
54Hippo signaling pathway_Homo sapiens_hsa043900.77750714
55Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.77733386
56mTOR signaling pathway_Homo sapiens_hsa041500.77595196
57Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.76408398
582-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.73834651
59Cyanoamino acid metabolism_Homo sapiens_hsa004600.73440158
60Basal cell carcinoma_Homo sapiens_hsa052170.73173023
61Transcriptional misregulation in cancer_Homo sapiens_hsa052020.73139832
62Carbon metabolism_Homo sapiens_hsa012000.72428416
63TGF-beta signaling pathway_Homo sapiens_hsa043500.70750588
64Bladder cancer_Homo sapiens_hsa052190.70348500
65Colorectal cancer_Homo sapiens_hsa052100.69714274
66Primary immunodeficiency_Homo sapiens_hsa053400.69362575
67Adherens junction_Homo sapiens_hsa045200.69002931
68Acute myeloid leukemia_Homo sapiens_hsa052210.67834812
69Fatty acid elongation_Homo sapiens_hsa000620.63369535
70Arginine and proline metabolism_Homo sapiens_hsa003300.63310363
71Huntingtons disease_Homo sapiens_hsa050160.61625333
72Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.60374286
73Apoptosis_Homo sapiens_hsa042100.59574649
74Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.57392947
75Central carbon metabolism in cancer_Homo sapiens_hsa052300.56506433
76Hepatitis B_Homo sapiens_hsa051610.56390911
77Shigellosis_Homo sapiens_hsa051310.54033562
78Drug metabolism - other enzymes_Homo sapiens_hsa009830.53300368
79Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.53293843
80Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.52231459
81Pancreatic cancer_Homo sapiens_hsa052120.51504898
82Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.51367054
83Viral myocarditis_Homo sapiens_hsa054160.51317772
84Alcoholism_Homo sapiens_hsa050340.50223993
85Hedgehog signaling pathway_Homo sapiens_hsa043400.49676276
86Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.48515109
87Legionellosis_Homo sapiens_hsa051340.47283672
88Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.46667019
89HIF-1 signaling pathway_Homo sapiens_hsa040660.46641295
90Thyroid hormone signaling pathway_Homo sapiens_hsa049190.46094993
91Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.45633511
92Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.45457574
93Phenylalanine metabolism_Homo sapiens_hsa003600.45210614
94Pathways in cancer_Homo sapiens_hsa052000.44997156
95Melanoma_Homo sapiens_hsa052180.44272054
96Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.43925216
97Measles_Homo sapiens_hsa051620.43714256
98Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.42817877
99Prostate cancer_Homo sapiens_hsa052150.40350528
100Proteoglycans in cancer_Homo sapiens_hsa052050.40105634
101NF-kappa B signaling pathway_Homo sapiens_hsa040640.39852581
102Metabolic pathways_Homo sapiens_hsa011000.39741422
103Vitamin digestion and absorption_Homo sapiens_hsa049770.38953498
104Insulin signaling pathway_Homo sapiens_hsa049100.38770691
105Fructose and mannose metabolism_Homo sapiens_hsa000510.37902679
106FoxO signaling pathway_Homo sapiens_hsa040680.37774465
107Fatty acid metabolism_Homo sapiens_hsa012120.35840294
108Circadian rhythm_Homo sapiens_hsa047100.34993209
109Vibrio cholerae infection_Homo sapiens_hsa051100.34819737
110Influenza A_Homo sapiens_hsa051640.34374897
111Non-small cell lung cancer_Homo sapiens_hsa052230.34308726
112B cell receptor signaling pathway_Homo sapiens_hsa046620.33391621
113Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.33190680
114Renal cell carcinoma_Homo sapiens_hsa052110.32677486
115Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.32445752
116AMPK signaling pathway_Homo sapiens_hsa041520.31854832
117Leukocyte transendothelial migration_Homo sapiens_hsa046700.31251334
118Endometrial cancer_Homo sapiens_hsa052130.30857873
119Glutathione metabolism_Homo sapiens_hsa004800.30848053
120Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.28672189
121Wnt signaling pathway_Homo sapiens_hsa043100.28299621
122Tight junction_Homo sapiens_hsa045300.27404166
123Longevity regulating pathway - mammal_Homo sapiens_hsa042110.27372887
124Jak-STAT signaling pathway_Homo sapiens_hsa046300.27302298
125Propanoate metabolism_Homo sapiens_hsa006400.27225466
126VEGF signaling pathway_Homo sapiens_hsa043700.27141127
127Glioma_Homo sapiens_hsa052140.25492113

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