DNAH1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an inner dynein arm heavy chain that provides structural support between the radial spokes and the outer doublet of the sperm tail. Naturally occurring mutations in this gene are associated with primary ciliary dyskinesia and multiple morphological anomalies of the flagella that result in asthenozoospermia and male infertility. Mice with a homozygous knockout of the orthologous gene are viable but have reduced sperm motility and are infertile. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)9.49985260
2motile cilium assembly (GO:0044458)9.22242010
3sperm-egg recognition (GO:0035036)8.68249565
4multicellular organism reproduction (GO:0032504)8.57923549
5male meiosis (GO:0007140)8.56592908
6acrosome reaction (GO:0007340)8.41533540
7acrosome assembly (GO:0001675)8.38185071
8plasma membrane fusion (GO:0045026)8.00735027
9binding of sperm to zona pellucida (GO:0007339)8.00567980
10spermatid development (GO:0007286)7.81771532
11synaptonemal complex organization (GO:0070193)7.77752561
12cell-cell recognition (GO:0009988)7.75895768
13regulation of cilium movement (GO:0003352)7.46107045
14ventricular system development (GO:0021591)7.32855331
15synaptonemal complex assembly (GO:0007130)7.12261913
16reproduction (GO:0000003)6.87213754
17DNA methylation involved in gamete generation (GO:0043046)6.70341839
18single fertilization (GO:0007338)6.20802100
19male meiosis I (GO:0007141)6.17499179
20cell wall macromolecule catabolic process (GO:0016998)5.86869315
21cell wall macromolecule metabolic process (GO:0044036)5.86869315
22axoneme assembly (GO:0035082)5.82500542
23sperm capacitation (GO:0048240)5.75150962
24negative regulation of inclusion body assembly (GO:0090084)5.50395793
25fertilization (GO:0009566)5.46561271
26protein localization to cilium (GO:0061512)5.37204127
27positive regulation of gamma-delta T cell activation (GO:0046645)5.28111258
28intraciliary transport (GO:0042073)5.15332816
29chromosome organization involved in meiosis (GO:0070192)4.94429746
30meiotic nuclear division (GO:0007126)4.92167080
31meiosis I (GO:0007127)4.90367367
32spermatogenesis (GO:0007283)4.89990203
33male gamete generation (GO:0048232)4.88043987
34negative regulation of cell killing (GO:0031342)4.86197812
35negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.86197812
36tolerance induction (GO:0002507)4.79747440
37germ cell development (GO:0007281)4.69053382
38antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.68125756
39regulation of microtubule-based movement (GO:0060632)4.67795281
40left/right pattern formation (GO:0060972)4.64775570
41microtubule severing (GO:0051013)4.63317586
42meiotic cell cycle (GO:0051321)4.57573021
43cellular process involved in reproduction in multicellular organism (GO:0022412)4.52552683
44gamete generation (GO:0007276)4.48544839
45calcium ion-dependent exocytosis (GO:0017156)4.44982729
46regulation of gamma-delta T cell activation (GO:0046643)4.41477782
47left/right axis specification (GO:0070986)4.36997061
48regulation of gamma-delta T cell differentiation (GO:0045586)4.35684096
49regulation of inclusion body assembly (GO:0090083)4.34742925
50cell recognition (GO:0008037)4.29435757
51antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.26350236
52seminiferous tubule development (GO:0072520)4.22755750
53* microtubule-based movement (GO:0007018)4.19572908
54positive thymic T cell selection (GO:0045059)4.19297169
55cilium organization (GO:0044782)4.19285105
56antigen processing and presentation of endogenous antigen (GO:0019883)4.16024834
57GTP biosynthetic process (GO:0006183)4.02448829
58negative thymic T cell selection (GO:0045060)4.00817899
59nucleoside diphosphate phosphorylation (GO:0006165)4.00030005
60positive regulation of tolerance induction (GO:0002645)3.95247592
61antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.94356949
62cilium assembly (GO:0042384)3.94282304
63regulation of B cell receptor signaling pathway (GO:0050855)3.91138647
64negative T cell selection (GO:0043383)3.90313206
65gene silencing by RNA (GO:0031047)3.87623554
66positive T cell selection (GO:0043368)3.81810071
67negative regulation of lymphocyte mediated immunity (GO:0002707)3.79468511
68protein polyglutamylation (GO:0018095)3.79277198
69regulation of tolerance induction (GO:0002643)3.78827168
70genitalia morphogenesis (GO:0035112)3.76050626
71negative regulation of organelle assembly (GO:1902116)3.73948051
72regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.70987721
73negative regulation of erythrocyte differentiation (GO:0045647)3.70768247
74thymic T cell selection (GO:0045061)3.66959371
75regulation of meiosis I (GO:0060631)3.65079712
76positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.62467224
77detection of other organism (GO:0098543)3.62269295
78T cell selection (GO:0045058)3.61188842
79negative regulation of B cell mediated immunity (GO:0002713)3.58909018
80negative regulation of immunoglobulin mediated immune response (GO:0002890)3.58909018
81organic cation transport (GO:0015695)3.58768753
82modulation by symbiont of host defense response (GO:0052031)3.57993447
83modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.57993447
84modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.57993447
85positive regulation by organism of defense response of other organism involved in symbiotic interact3.57993447
86modulation by symbiont of host immune response (GO:0052553)3.57993447
87positive regulation by symbiont of host defense response (GO:0052509)3.57993447
88detection of bacterium (GO:0016045)3.56180381
89UTP biosynthetic process (GO:0006228)3.54853884
90macrophage activation involved in immune response (GO:0002281)3.53733296
91cilium morphogenesis (GO:0060271)3.53114072
92multicellular organismal reproductive process (GO:0048609)3.53071462
93response to muramyl dipeptide (GO:0032495)3.48881414
94cellular component assembly involved in morphogenesis (GO:0010927)3.48876581
95B cell receptor signaling pathway (GO:0050853)3.44499755
96negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.42294396
97negative regulation of T-helper cell differentiation (GO:0045623)3.42294396
98microtubule depolymerization (GO:0007019)3.39275197
99negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.37753002
100histone H3-K36 demethylation (GO:0070544)3.37603732
101leukocyte aggregation (GO:0070486)3.36783479
102negative regulation of leukocyte mediated immunity (GO:0002704)3.34687396
103germinal center formation (GO:0002467)3.33280311
104cellular extravasation (GO:0045123)3.31836128
105regulation of germinal center formation (GO:0002634)3.23776224
106regulation of T-helper 2 cell differentiation (GO:0045628)3.23102116
107UTP metabolic process (GO:0046051)3.17591600
108regulation of centriole replication (GO:0046599)3.11693164
109monoubiquitinated protein deubiquitination (GO:0035520)3.09514864
110microtubule bundle formation (GO:0001578)3.08652529
111detection of external biotic stimulus (GO:0098581)3.05973142
112negative regulation of type 2 immune response (GO:0002829)3.04122575
113negative regulation of T cell mediated immunity (GO:0002710)3.02372952
114negative regulation of adaptive immune response (GO:0002820)3.01883226
115response to interleukin-15 (GO:0070672)3.01089987
116positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.99443122
117negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.99312964
118activated T cell proliferation (GO:0050798)2.99263658
119meiotic cell cycle process (GO:1903046)2.99151911
120positive regulation of granulocyte differentiation (GO:0030854)2.98900367
121response to peptidoglycan (GO:0032494)2.97705550
122spermatid nucleus differentiation (GO:0007289)2.97489692
123regulation of protein polyubiquitination (GO:1902914)2.96102115
124positive regulation of B cell differentiation (GO:0045579)2.91275515
125synapsis (GO:0007129)2.90345335
126T cell migration (GO:0072678)2.90187827
127regulation of B cell differentiation (GO:0045577)2.87801072
128negative regulation of DNA repair (GO:0045738)2.87610308
129negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.85525911
130multicellular organismal development (GO:0007275)2.84687206
131centriole replication (GO:0007099)2.82421114
132detection of molecule of bacterial origin (GO:0032490)2.78587461
133negative regulation of interleukin-12 production (GO:0032695)2.78534544
134lactate metabolic process (GO:0006089)2.76113921
135microglial cell activation (GO:0001774)2.75994296
136mannose metabolic process (GO:0006013)2.75565010
137neutrophil activation involved in immune response (GO:0002283)2.75042328
138negative regulation of humoral immune response (GO:0002921)2.73563578
139cellular response to ethanol (GO:0071361)2.73497267
140centriole assembly (GO:0098534)2.70424112
141negative regulation of interleukin-6 production (GO:0032715)2.69511935
142detection of biotic stimulus (GO:0009595)2.68848059
143macrophage activation (GO:0042116)2.68594279
144protein refolding (GO:0042026)2.67942758
145DNA alkylation (GO:0006305)2.66369926
146DNA methylation (GO:0006306)2.66369926
147regulation of T cell tolerance induction (GO:0002664)2.65687233
148positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.64136717
149sex differentiation (GO:0007548)2.63966100
150guanosine-containing compound biosynthetic process (GO:1901070)2.63655387
151chaperone-mediated protein complex assembly (GO:0051131)2.61704579
152regulation of ARF protein signal transduction (GO:0032012)2.61562663
153regulation of granulocyte differentiation (GO:0030852)2.60079266
154myeloid cell activation involved in immune response (GO:0002275)2.58063694
155regulation of myeloid leukocyte mediated immunity (GO:0002886)2.57592090
156CTP metabolic process (GO:0046036)2.54938786
157CTP biosynthetic process (GO:0006241)2.54938786
158cell projection assembly (GO:0030031)2.54185080
159response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.53548008
160response to host immune response (GO:0052572)2.53548008
161regulation of interferon-beta biosynthetic process (GO:0045357)2.53156007
162gene silencing (GO:0016458)2.52856500
163response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.52650183
164response to host (GO:0075136)2.52650183
165response to host defenses (GO:0052200)2.52650183
166response to type I interferon (GO:0034340)2.52577014
167regulation of protein kinase A signaling (GO:0010738)2.51873669
168cellular response to interleukin-15 (GO:0071350)2.49241068
169immunoglobulin mediated immune response (GO:0016064)2.48681988
170carnitine transmembrane transport (GO:1902603)2.48484735
171negative regulation of granulocyte differentiation (GO:0030853)2.47570206
172type I interferon signaling pathway (GO:0060337)2.46917473
173cellular response to type I interferon (GO:0071357)2.46917473
174regulation of alpha-beta T cell proliferation (GO:0046640)2.46593493
175regulation of mast cell degranulation (GO:0043304)2.46345823
176negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.46025739
177antigen processing and presentation via MHC class Ib (GO:0002475)2.46017138
178membrane depolarization during action potential (GO:0086010)2.43681138
179carnitine transport (GO:0015879)2.43105133
180amino-acid betaine transport (GO:0015838)2.43105133
181* microtubule-based process (GO:0007017)2.41818430
182peptidyl-glutamic acid modification (GO:0018200)2.38145167
183nuclear pore complex assembly (GO:0051292)2.36641505
184mitotic sister chromatid cohesion (GO:0007064)2.32944534
185regulation of acrosome reaction (GO:0060046)2.31553050
186* cilium or flagellum-dependent cell motility (GO:0001539)16.5094861
187axonemal dynein complex assembly (GO:0070286)11.7380200
188epithelial cilium movement (GO:0003351)10.6336252
189piRNA metabolic process (GO:0034587)10.5332616
190fusion of sperm to egg plasma membrane (GO:0007342)10.2985173
191* cilium movement (GO:0003341)10.1501187
192sperm motility (GO:0030317)10.0395544

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse8.10008147
2EZH2_22144423_ChIP-Seq_EOC_Human8.04816125
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.22033213
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.09369549
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.54606121
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.22114017
7BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.07416299
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.71003003
9RUNX_20019798_ChIP-Seq_JUKART_Human2.69751170
10ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.49174872
11MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.37505377
12VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.34480617
13NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.32395349
14ZNF274_21170338_ChIP-Seq_K562_Hela2.30418203
15VDR_21846776_ChIP-Seq_THP-1_Human2.28929152
16SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.28907607
17PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.27482183
18KDM2B_26808549_Chip-Seq_SUP-B15_Human2.26726331
19IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.23626335
20VDR_24763502_ChIP-Seq_THP-1_Human2.22338264
21SCL_19346495_ChIP-Seq_HPC-7_Human2.18718712
22BP1_19119308_ChIP-ChIP_Hs578T_Human2.17870010
23IRF8_27001747_Chip-Seq_BMDM_Mouse2.17838380
24FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.13162740
25MAF_26560356_Chip-Seq_TH1_Human2.06184494
26REST_21632747_ChIP-Seq_MESCs_Mouse2.03535456
27* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.03204262
28TCF7_22412390_ChIP-Seq_EML_Mouse2.00863814
29SPI1_23127762_ChIP-Seq_K562_Human1.97861523
30MYB_26560356_Chip-Seq_TH2_Human1.93493330
31CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.92173085
32STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.91937510
33NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.88046284
34GATA1_26923725_Chip-Seq_HPCs_Mouse1.86588563
35FLI1_27457419_Chip-Seq_LIVER_Mouse1.86383079
36KDM2B_26808549_Chip-Seq_DND41_Human1.78046846
37UTX_26944678_Chip-Seq_JUKART_Human1.77843477
38KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.77519291
39IRF8_21731497_ChIP-ChIP_J774_Mouse1.77262645
40RUNX1_22412390_ChIP-Seq_EML_Mouse1.75116144
41MYC_22102868_ChIP-Seq_BL_Human1.74753562
42GATA1_19941826_ChIP-Seq_K562_Human1.71123197
43RBPJ_22232070_ChIP-Seq_NCS_Mouse1.70759849
44ELK4_26923725_Chip-Seq_MESODERM_Mouse1.70665371
45CBX2_27304074_Chip-Seq_ESCs_Mouse1.68905958
46CTBP2_25329375_ChIP-Seq_LNCAP_Human1.68704499
47GATA1_19941827_ChIP-Seq_MEL_Mouse1.66807867
48PCGF2_27294783_Chip-Seq_ESCs_Mouse1.66598323
49MYB_26560356_Chip-Seq_TH1_Human1.64321656
50RNF2_27304074_Chip-Seq_NSC_Mouse1.62470627
51MYB_21317192_ChIP-Seq_ERMYB_Mouse1.61493972
52KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.60002268
53RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.58397392
54LXR_22292898_ChIP-Seq_THP-1_Human1.56458263
55VDR_24787735_ChIP-Seq_THP-1_Human1.54757826
56MAF_26560356_Chip-Seq_TH2_Human1.52176888
57VDR_22108803_ChIP-Seq_LS180_Human1.51600277
58TAF15_26573619_Chip-Seq_HEK293_Human1.51519087
59BRD4_27068464_Chip-Seq_AML-cells_Mouse1.51027931
60GATA3_27048872_Chip-Seq_THYMUS_Human1.50467394
61EGR1_19374776_ChIP-ChIP_THP-1_Human1.50179375
62GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.47944820
63THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.47028733
64WDR5_24793694_ChIP-Seq_LNCAP_Human1.45104889
65EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.43052271
66ZFP57_27257070_Chip-Seq_ESCs_Mouse1.42647935
67PCGF2_27294783_Chip-Seq_NPCs_Mouse1.41528435
68* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.41523005
69* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.41161582
70* CBP_20019798_ChIP-Seq_JUKART_Human1.41161582
71RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.39970819
72KDM2B_26808549_Chip-Seq_JURKAT_Human1.39649671
73CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.39422382
74TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.38159448
75POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.38159448
76GBX2_23144817_ChIP-Seq_PC3_Human1.37791537
77NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.37188556
78DROSHA_22980978_ChIP-Seq_HELA_Human1.37145885
79SMAD4_21799915_ChIP-Seq_A2780_Human1.36541624
80TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.35303380
81Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.34238733
82TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.33996691
83KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.32232730
84NFE2_27457419_Chip-Seq_LIVER_Mouse1.31775544
85CTBP1_25329375_ChIP-Seq_LNCAP_Human1.31255353
86* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.30992890
87MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.30721456
88TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.29248216
89SUZ12_27294783_Chip-Seq_NPCs_Mouse1.29185011
90SPI1_23547873_ChIP-Seq_NB4_Human1.26429879
91STAT4_19710469_ChIP-ChIP_TH1__Mouse1.26337247
92TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.25493033
93GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23144694
94SMC4_20622854_ChIP-Seq_HELA_Human1.22732614
95RUNX1_27514584_Chip-Seq_MCF-7_Human1.22324406
96GATA2_19941826_ChIP-Seq_K562_Human1.22001476
97* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.21162143
98TAL1_26923725_Chip-Seq_HPCs_Mouse1.21138105
99SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.20853057
100SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.20484274
101TCF4_23295773_ChIP-Seq_U87_Human1.20214754
102SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.19329010
103IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.18809685
104SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.18353218
105SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.17999480
106STAT6_21828071_ChIP-Seq_BEAS2B_Human1.17829440
107SUZ12_27294783_Chip-Seq_ESCs_Mouse1.17787989
108MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.17657388
109RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.16966032
110NANOG_18555785_Chip-Seq_ESCs_Mouse1.16253843
111CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.16242464
112GATA2_21666600_ChIP-Seq_HMVEC_Human1.16190976
113ESR2_21235772_ChIP-Seq_MCF-7_Human1.15856866
114ELK3_25401928_ChIP-Seq_HUVEC_Human1.15614855
115KDM2B_26808549_Chip-Seq_REH_Human1.15541955
116VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.15004462
117BCAT_22108803_ChIP-Seq_LS180_Human1.14295231
118TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14155101
119EZH2_27294783_Chip-Seq_ESCs_Mouse1.12826567
120REST_18959480_ChIP-ChIP_MESCs_Mouse1.12374005
121EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.11983150
122ER_23166858_ChIP-Seq_MCF-7_Human1.11962044
123SMAD_19615063_ChIP-ChIP_OVARY_Human1.11429824
124MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.10794261
125EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.10365544
126RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.09939137
127FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.08496626
128FUS_26573619_Chip-Seq_HEK293_Human1.08421104
129PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07706729
130KDM2B_26808549_Chip-Seq_K562_Human1.07597795
131BMI1_23680149_ChIP-Seq_NPCS_Mouse1.06977450
132FLI1_21867929_ChIP-Seq_TH2_Mouse1.06164178
133STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.05489197
134ELF1_20517297_ChIP-Seq_JURKAT_Human1.03596292
135SMAD4_21741376_ChIP-Seq_EPCs_Human1.03083397
136CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02286519
137P53_22387025_ChIP-Seq_ESCs_Mouse1.02158507
138SMAD3_21741376_ChIP-Seq_EPCs_Human1.02033360
139GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.01985916
140ESR1_20079471_ChIP-ChIP_T-47D_Human1.00906947
141PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.00874041
142P68_20966046_ChIP-Seq_HELA_Human1.00074209
143STAT1_17558387_ChIP-Seq_HELA_Human0.99936423
144PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99221840
145SMAD3_21741376_ChIP-Seq_ESCs_Human0.98943334
146P300_18555785_Chip-Seq_ESCs_Mouse0.98697641
147STAT3_23295773_ChIP-Seq_U87_Human0.98353855
148CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.98344277
149BCOR_27268052_Chip-Seq_Bcells_Human0.98056171
150GATA3_26560356_Chip-Seq_TH2_Human0.97510276
151OCT4_18555785_Chip-Seq_ESCs_Mouse0.97416107
152STAT3_18555785_Chip-Seq_ESCs_Mouse0.96595430
153BCL6_27268052_Chip-Seq_Bcells_Human0.96528908
154SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.95615932
155NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.95571402
156GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.95315617
157SOX9_26525672_Chip-Seq_HEART_Mouse0.94129944
158SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.94118526
159LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.93940042
160EZH2_27294783_Chip-Seq_NPCs_Mouse0.93679935
161EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.93623669
162* TP63_22573176_ChIP-Seq_HFKS_Human0.93312404
163RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.93229037
164CMYC_18555785_Chip-Seq_ESCs_Mouse0.93165732
165SMRT_27268052_Chip-Seq_Bcells_Human0.92341038
166CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91761477
167ESRRB_18555785_Chip-Seq_ESCs_Mouse0.91584631
168KLF4_18555785_Chip-Seq_ESCs_Mouse0.91397249
169E2F1_18555785_Chip-Seq_ESCs_Mouse0.91343705
170TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.90996925
171FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.90398442
172RNF2_27304074_Chip-Seq_ESCs_Mouse0.90333172
173TBL1_22424771_ChIP-Seq_293T_Human0.90211884
174CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.90019365
175AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.89844046
176SA1_27219007_Chip-Seq_ERYTHROID_Human0.89677051
177STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.89554862
178CRX_20693478_ChIP-Seq_RETINA_Mouse0.89521655
179MTF2_20144788_ChIP-Seq_MESCs_Mouse0.89363224
180SOX2_22085726_ChIP-Seq_NPCs_Mouse0.88882507
181MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.88851166
182TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.88836089
183CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.88620623
184FOXA2_19822575_ChIP-Seq_HepG2_Human0.88598298
185P300_19829295_ChIP-Seq_ESCs_Human0.87952822
186RUNX1_27457419_Chip-Seq_LIVER_Mouse0.87891880
187PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.87753170
188SUZ12_18555785_Chip-Seq_ESCs_Mouse0.87358361
189KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.87278919
190RACK7_27058665_Chip-Seq_MCF-7_Human0.87107907
191GATA1_22383799_ChIP-Seq_G1ME_Mouse0.87044612
192CTNNB1_20460455_ChIP-Seq_HCT116_Human0.86919238
193OCT4_21477851_ChIP-Seq_ESCs_Mouse0.86650569
194CTCF_27219007_Chip-Seq_ERYTHROID_Human0.86590406
195RUNX1_26923725_Chip-Seq_HPCs_Mouse0.86331987
196IKZF1_21737484_ChIP-ChIP_HCT116_Human0.86233305

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation5.31890862
2MP0003698_abnormal_male_reproductive4.75568124
3MP0001929_abnormal_gametogenesis4.23292523
4MP0002653_abnormal_ependyma_morphology4.13692936
5MP0003436_decreased_susceptibility_to3.66265825
6MP0003303_peritoneal_inflammation3.35218773
7MP0001835_abnormal_antigen_presentation3.26363840
8MP0003763_abnormal_thymus_physiology3.21145433
9MP0003724_increased_susceptibility_to3.17709393
10MP0002210_abnormal_sex_determination3.15666830
11MP0005623_abnormal_meninges_morphology2.88947587
12MP0001800_abnormal_humoral_immune2.77679451
13MP0005387_immune_system_phenotype2.69661367
14MP0001790_abnormal_immune_system2.69661367
15MP0002132_abnormal_respiratory_system2.69482652
16MP0009046_muscle_twitch2.63281629
17MP0001145_abnormal_male_reproductive2.58056067
18MP0002161_abnormal_fertility/fecundity2.53474663
19MP0002419_abnormal_innate_immunity2.53201666
20MP0000685_abnormal_immune_system2.41752644
21MP0005025_abnormal_response_to2.41638989
22MP0004859_abnormal_synaptic_plasticity2.41044567
23MP0005000_abnormal_immune_tolerance2.38203964
24MP0005671_abnormal_response_to2.34169703
25MP0002723_abnormal_immune_serum2.27217014
26MP0000653_abnormal_sex_gland2.24453751
27MP0002420_abnormal_adaptive_immunity2.21231137
28MP0003880_abnormal_central_pattern2.20523403
29MP0002452_abnormal_antigen_presenting2.19615159
30MP0002405_respiratory_system_inflammati2.18921298
31MP0001819_abnormal_immune_cell2.18775948
32MP0003172_abnormal_lysosome_physiology2.18301876
33MP0003300_gastrointestinal_ulcer2.16859904
34MP0010155_abnormal_intestine_physiology2.03961964
35MP0006082_CNS_inflammation2.00778521
36MP0005410_abnormal_fertilization10.9010419
37MP0003122_maternal_imprinting1.99871747
38MP0004947_skin_inflammation1.91607512
39MP0005464_abnormal_platelet_physiology1.84869245
40MP0005645_abnormal_hypothalamus_physiol1.84425691
41MP0009278_abnormal_bone_marrow1.82499213
42MP0002398_abnormal_bone_marrow1.80945629
43MP0009785_altered_susceptibility_to1.80242142
44MP0003866_abnormal_defecation1.79342062
45MP0002160_abnormal_reproductive_system1.75062256
46MP0000716_abnormal_immune_system1.74415611
47MP0003635_abnormal_synaptic_transmissio1.72590209
48MP0000465_gastrointestinal_hemorrhage1.71953447
49MP0001533_abnormal_skeleton_physiology1.71819806
50MP0008057_abnormal_DNA_replication1.71681742
51MP0003191_abnormal_cellular_cholesterol1.71191708
52MP0005423_abnormal_somatic_nervous1.68870830
53MP0001984_abnormal_olfaction1.66921158
54MP0001968_abnormal_touch/_nociception1.66565779
55MP0001440_abnormal_grooming_behavior1.64839150
56MP0005646_abnormal_pituitary_gland1.61354898
57MP0000703_abnormal_thymus_morphology1.54736622
58MP0003828_pulmonary_edema1.54505387
59MP0006276_abnormal_autonomic_nervous1.54165320
60MP0008875_abnormal_xenobiotic_pharmacok1.53555208
61MP0008260_abnormal_autophagy1.53028172
62MP0001851_eye_inflammation1.51984178
63MP0009745_abnormal_behavioral_response1.51648980
64MP0001845_abnormal_inflammatory_respons1.49705805
65MP0002396_abnormal_hematopoietic_system1.49596767
66MP0009333_abnormal_splenocyte_physiolog1.48639770
67MP0002722_abnormal_immune_system1.48184124
68MP0002282_abnormal_trachea_morphology1.47999745
69MP0002572_abnormal_emotion/affect_behav1.47148861
70MP0000689_abnormal_spleen_morphology1.46219000
71MP0005310_abnormal_salivary_gland1.45591213
72MP0002736_abnormal_nociception_after1.45342097
73MP0002148_abnormal_hypersensitivity_rea1.45099022
74MP0004381_abnormal_hair_follicle1.43725707
75MP0008995_early_reproductive_senescence1.42584305
76MP0005397_hematopoietic_system_phenotyp1.42021642
77MP0001545_abnormal_hematopoietic_system1.42021642
78MP0003656_abnormal_erythrocyte_physiolo1.41792266
79MP0002063_abnormal_learning/memory/cond1.41755558
80MP0002998_abnormal_bone_remodeling1.37692419
81MP0002064_seizures1.34302317
82MP0003690_abnormal_glial_cell1.34123988
83MP0002009_preneoplasia1.33488155
84MP0001873_stomach_inflammation1.33125386
85MP0002429_abnormal_blood_cell1.32316860
86MP0003123_paternal_imprinting1.31116886
87MP0004883_abnormal_blood_vessel1.30642712
88MP0002735_abnormal_chemical_nociception1.29837353
89MP0004130_abnormal_muscle_cell1.28645560
90MP0002933_joint_inflammation1.25310793
91MP0002166_altered_tumor_susceptibility1.23834957
92MP0001501_abnormal_sleep_pattern1.23040564
93MP0008469_abnormal_protein_level1.22042461
94MP0003787_abnormal_imprinting1.21986374
95MP0002277_abnormal_respiratory_mucosa1.21907220
96MP0002272_abnormal_nervous_system1.21775885
97MP0003121_genomic_imprinting1.17621748
98MP0000858_altered_metastatic_potential1.15026774
99MP0001986_abnormal_taste_sensitivity1.12924866
100MP0004270_analgesia1.12342832
101MP0005058_abnormal_lysosome_morphology1.12116477
102MP0003045_fibrosis1.11818707
103MP0003646_muscle_fatigue1.11621651
104MP0000778_abnormal_nervous_system1.09206080
105MP0002557_abnormal_social/conspecific_i1.07112314
106MP0005164_abnormal_response_to1.06889048
107MP0005451_abnormal_body_composition1.06687725
108MP0003091_abnormal_cell_migration1.04227126
109MP0001486_abnormal_startle_reflex1.02649246
110MP0004233_abnormal_muscle_weight1.01649691
111MP0001853_heart_inflammation1.00586567
112MP0000569_abnormal_digit_pigmentation1.00483318
113MP0002734_abnormal_mechanical_nocicepti0.99820463
114MP0009764_decreased_sensitivity_to0.99004164
115MP0008004_abnormal_stomach_pH0.98726357
116MP0002168_other_aberrant_phenotype0.96363082
117MP0005647_abnormal_sex_gland0.96298680
118MP0000249_abnormal_blood_vessel0.93462884
119MP0005166_decreased_susceptibility_to0.93356352
120MP0000604_amyloidosis0.93041757
121MP0004808_abnormal_hematopoietic_stem0.91673082
122MP0002067_abnormal_sensory_capabilities0.91428118
123MP0005409_darkened_coat_color0.90945860
124MP0004264_abnormal_extraembryonic_tissu0.90649689
125MP0001663_abnormal_digestive_system0.90474782
126MP0005670_abnormal_white_adipose0.88609220
127MP0004811_abnormal_neuron_physiology0.88556409
128MP0005076_abnormal_cell_differentiation0.87477442
129MP0003075_altered_response_to0.87318736
130MP0000955_abnormal_spinal_cord0.84635186
131MP0002152_abnormal_brain_morphology0.84488442
132MP0005389_reproductive_system_phenotype0.84139099
133MP0000631_abnormal_neuroendocrine_gland0.83874038
134MP0003183_abnormal_peptide_metabolism0.82552946
135MP0008058_abnormal_DNA_repair0.81454694
136MP0003252_abnormal_bile_duct0.81135674
137MP0004510_myositis0.80701896
138MP0004134_abnormal_chest_morphology0.80165440
139MP0002138_abnormal_hepatobiliary_system0.79807309
140MP0004133_heterotaxia0.76283418
141MP0009763_increased_sensitivity_to0.76219907
142MP0003879_abnormal_hair_cell0.75534861
143MP0002822_catalepsy0.74952765
144MP0005551_abnormal_eye_electrophysiolog0.74221886
145MP0002102_abnormal_ear_morphology0.73543225
146MP0009115_abnormal_fat_cell0.72638980
147MP0002184_abnormal_innervation0.72013143
148MP0000751_myopathy0.70800819
149MP0003861_abnormal_nervous_system0.70694587
150MP0006072_abnormal_retinal_apoptosis0.70083543
151MP0002882_abnormal_neuron_morphology0.69989568
152MP0005253_abnormal_eye_physiology0.68728691
153MP0008569_lethality_at_weaning0.68123378
154MP0005377_hearing/vestibular/ear_phenot0.67700524
155MP0003878_abnormal_ear_physiology0.67700524
156MP0001958_emphysema0.67137693
157MP0005390_skeleton_phenotype0.67088645
158MP0001529_abnormal_vocalization0.66740400
159MP0002136_abnormal_kidney_physiology0.66689777
160MP0003786_premature_aging0.65666637
161MP0002332_abnormal_exercise_endurance0.64877221
162MP0004043_abnormal_pH_regulation0.64862284
163MP0005365_abnormal_bile_salt0.64663733
164MP0009765_abnormal_xenobiotic_induced0.63964043
165MP0003942_abnormal_urinary_system0.63834919
166MP0001765_abnormal_ion_homeostasis0.63477121
167MP0003329_amyloid_beta_deposits0.63470389
168MP0002133_abnormal_respiratory_system0.62312162
169MP0010094_abnormal_chromosome_stability0.60279134
170MP0002066_abnormal_motor_capabilities/c0.60258188
171MP0002234_abnormal_pharynx_morphology0.59978032
172MP0001970_abnormal_pain_threshold0.59454951
173MP0002733_abnormal_thermal_nociception0.59138003
174MP0004924_abnormal_behavior0.58662244
175MP0005386_behavior/neurological_phenoty0.58662244
176MP0003633_abnormal_nervous_system0.58439971
177MP0003011_delayed_dark_adaptation0.54389673
178MP0001502_abnormal_circadian_rhythm0.53075990
179MP0002876_abnormal_thyroid_physiology0.52778733
180MP0003959_abnormal_lean_body0.52697088
181MP0004142_abnormal_muscle_tone0.52568740
182MP0002928_abnormal_bile_duct0.51590734
183MP0000534_abnormal_ureter_morphology0.48883845
184MP0008961_abnormal_basal_metabolism0.48646160
185MP0008007_abnormal_cellular_replicative0.48185182
186MP0002909_abnormal_adrenal_gland0.48174962
187MP0003115_abnormal_respiratory_system0.47681449
188MP0003631_nervous_system_phenotype0.47582105
189MP0002638_abnormal_pupillary_reflex0.46466967
190MP0001963_abnormal_hearing_physiology0.45146265
191MP0008872_abnormal_physiological_respon0.44982434
192MP0005391_vision/eye_phenotype0.44321312
193MP0002752_abnormal_somatic_nervous0.44023051
194MP0004742_abnormal_vestibular_system0.43082775

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.84853093
2Abnormal respiratory motile cilium morphology (HP:0005938)8.61631925
3Abnormal respiratory epithelium morphology (HP:0012253)8.61631925
4Abnormal ciliary motility (HP:0012262)8.50591870
5Rhinitis (HP:0012384)8.39775662
6Chronic bronchitis (HP:0004469)6.59002257
7Nasal polyposis (HP:0100582)5.36628980
8Infertility (HP:0000789)5.28514449
9Nephronophthisis (HP:0000090)4.78916409
10Bronchiectasis (HP:0002110)4.65205273
11Abnormality of the nasal mucosa (HP:0000433)4.36130645
12Eczematoid dermatitis (HP:0000976)4.01464331
13Bronchitis (HP:0012387)3.90605206
14Abnormality of the lower motor neuron (HP:0002366)3.74363425
15Abnormality of the renal medulla (HP:0100957)3.64235175
16Myositis (HP:0100614)3.45643837
17Recurrent bacterial skin infections (HP:0005406)3.38440425
18Recurrent abscess formation (HP:0002722)3.36810763
19Tubulointerstitial nephritis (HP:0001970)3.31237107
20Elevated erythrocyte sedimentation rate (HP:0003565)3.26385577
21Chronic otitis media (HP:0000389)3.17162759
22Recurrent gram-negative bacterial infections (HP:0005420)3.12364267
23Recurrent sinusitis (HP:0011108)3.08024646
24Molar tooth sign on MRI (HP:0002419)3.04882985
25Abnormality of midbrain morphology (HP:0002418)3.04882985
26Recurrent otitis media (HP:0000403)3.04179725
27Fibular hypoplasia (HP:0003038)2.99914747
28Medial flaring of the eyebrow (HP:0010747)2.86403582
29Abnormal delayed hypersensitivity skin test (HP:0002963)2.84485973
30Amyotrophic lateral sclerosis (HP:0007354)2.82282872
31Colitis (HP:0002583)2.79398200
32Abnormality of the fingertips (HP:0001211)2.77405452
33Recurrent fungal infections (HP:0002841)2.76822178
34Tubular atrophy (HP:0000092)2.74456790
35Orchitis (HP:0100796)2.70512782
36Optic neuritis (HP:0100653)2.66425666
37Retrobulbar optic neuritis (HP:0100654)2.66425666
38Obstructive sleep apnea (HP:0002870)2.60845772
39Postaxial foot polydactyly (HP:0001830)2.58939134
40Gonadotropin excess (HP:0000837)2.57791979
41Panhypogammaglobulinemia (HP:0003139)2.53669980
42Gingivitis (HP:0000230)2.53007683
43Tubulointerstitial abnormality (HP:0001969)2.49043390
44Chronic mucocutaneous candidiasis (HP:0002728)2.47479083
45Recurrent cutaneous fungal infections (HP:0011370)2.47479083
46Meningitis (HP:0001287)2.46092125
47Abnormality of macrophages (HP:0004311)2.40569187
48Prolonged bleeding time (HP:0003010)2.40433919
49Recurrent skin infections (HP:0001581)2.37765285
50Increased IgE level (HP:0003212)2.37296282
51Inflammation of the large intestine (HP:0002037)2.36712289
52Stomatitis (HP:0010280)2.34946843
53Supernumerary spleens (HP:0009799)2.32875683
54Male infertility (HP:0003251)2.32693925
55Gastrointestinal inflammation (HP:0004386)2.31781903
56Gastrointestinal infarctions (HP:0005244)2.31124919
57Mediastinal lymphadenopathy (HP:0100721)2.30645980
58Pancreatic fibrosis (HP:0100732)2.30010474
59Papilledema (HP:0001085)2.23609008
60Recurrent viral infections (HP:0004429)2.22360680
61Spontaneous hematomas (HP:0007420)2.22309773
62Congenital hepatic fibrosis (HP:0002612)2.22188468
63Median cleft lip (HP:0000161)2.21867953
64Stage 5 chronic kidney disease (HP:0003774)2.21062079
65Atelectasis (HP:0100750)2.21018085
66T lymphocytopenia (HP:0005403)2.19297055
67Pustule (HP:0200039)2.17159932
68Vasculitis (HP:0002633)2.15291509
69Chronic sinusitis (HP:0011109)2.13287511
70Recurrent bronchitis (HP:0002837)2.11673839
71True hermaphroditism (HP:0010459)2.10600426
72Oculomotor apraxia (HP:0000657)2.06680083
73Abnormality of dentin (HP:0010299)2.04012005
74Abnormality of T cell number (HP:0011839)2.03576855
75Epistaxis (HP:0000421)2.02376015
76Gait imbalance (HP:0002141)2.01358043
77Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.1290181
78Dynein arm defect of respiratory motile cilia (HP:0012255)11.2236710
79Absent/shortened dynein arms (HP:0200106)11.2236710
80Abnormal biliary tract physiology (HP:0012439)1.99709379
81Bile duct proliferation (HP:0001408)1.99709379
82Chronic obstructive pulmonary disease (HP:0006510)1.99664175
83Obstructive lung disease (HP:0006536)1.99664175
84Congenital primary aphakia (HP:0007707)1.98447571
85Encephalitis (HP:0002383)1.97435407
86Microglossia (HP:0000171)1.97110846
87Renal dysplasia (HP:0000110)1.93958056
88Abnormality of permanent molar morphology (HP:0011071)1.93369536
89Abnormality of the dental root (HP:0006486)1.93369536
90Taurodontia (HP:0000679)1.93369536
91Agammaglobulinemia (HP:0004432)1.92864130
92Postaxial hand polydactyly (HP:0001162)1.92456029
93Abnormal drinking behavior (HP:0030082)1.92265791
94Polydipsia (HP:0001959)1.92265791
95Abnormal spermatogenesis (HP:0008669)1.90949581
96Aplasia/Hypoplasia of the tongue (HP:0010295)1.90425749
97Cellulitis (HP:0100658)1.90317287
98Short ribs (HP:0000773)1.89496756
99Hemoptysis (HP:0002105)1.87685388
100Chest pain (HP:0100749)1.86536567
101Pulmonary infiltrates (HP:0002113)1.86204343
102Aplasia/Hypoplasia of the fibula (HP:0006492)1.85532905
103Cystic liver disease (HP:0006706)1.84318998
104Facial cleft (HP:0002006)1.84090635
105Keratoconjunctivitis sicca (HP:0001097)1.83747597
106Broad distal phalanx of finger (HP:0009836)1.83744629
107Pulmonary embolism (HP:0002204)1.81941009
10811 pairs of ribs (HP:0000878)1.81380341
109Gingival bleeding (HP:0000225)1.81204498
110Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.80954700
111Abnormality of molar (HP:0011077)1.80073703
112Abnormality of molar morphology (HP:0011070)1.80073703
113Hyperactive renin-angiotensin system (HP:0000841)1.78707832
114Interstitial pulmonary disease (HP:0006530)1.78545416
115Upper motor neuron abnormality (HP:0002127)1.77683800
116Impaired proprioception (HP:0010831)1.75234072
117Abnormality of T cells (HP:0002843)1.74684198
118Abnormality of the dental pulp (HP:0006479)1.74476286
119Tubulointerstitial fibrosis (HP:0005576)1.74430649
120Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.74429592
121Absent frontal sinuses (HP:0002688)1.73150967
122Arterial thrombosis (HP:0004420)1.72852980
123Autoimmune thrombocytopenia (HP:0001973)1.72744471
124Nephrogenic diabetes insipidus (HP:0009806)1.72017608
125Abnormality of the renal cortex (HP:0011035)1.71869651
126Leukocytosis (HP:0001974)1.71173664
127Granulocytopenia (HP:0001913)1.64959853
128Keratoconjunctivitis (HP:0001096)1.64651428
129Glucose intolerance (HP:0000833)1.63275408
130Azoospermia (HP:0000027)1.61156858
131Hypoplasia of the capital femoral epiphysis (HP:0003090)1.60267700
132Gaze-evoked nystagmus (HP:0000640)1.59711745
133J-shaped sella turcica (HP:0002680)1.59434201
134Abnormality of ocular smooth pursuit (HP:0000617)1.59279501
135Autoimmune hemolytic anemia (HP:0001890)1.58690472
136Hemorrhage of the eye (HP:0011885)1.58420489
137Chronic hepatic failure (HP:0100626)1.58279622
138Neoplasm of the tracheobronchial system (HP:0100552)1.58177268
139Alveolar cell carcinoma (HP:0006519)1.58091368
140Broad face (HP:0000283)1.56931835
141Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.56646137
142Systemic lupus erythematosus (HP:0002725)1.56444454
143Hyperkalemia (HP:0002153)1.56211683
144Slow saccadic eye movements (HP:0000514)1.54420140
145Purpura (HP:0000979)1.54402035
146Genital tract atresia (HP:0001827)1.54232161
147Bell-shaped thorax (HP:0001591)1.54073421
148Short thorax (HP:0010306)1.53871540
149Decreased circulating renin level (HP:0003351)1.53715098
150Amyloidosis (HP:0011034)1.51946005
151Viral hepatitis (HP:0006562)1.51774056
152Hypochromic anemia (HP:0001931)1.50966870
153Recurrent pneumonia (HP:0006532)1.49498065
154Nephropathy (HP:0000112)1.49148641
155Degeneration of anterior horn cells (HP:0002398)1.48119525
156Abnormality of the anterior horn cell (HP:0006802)1.48119525
157Gastrointestinal stroma tumor (HP:0100723)1.46748525
158Impulsivity (HP:0100710)1.46330268
159Increased CSF protein (HP:0002922)1.46046418
160Occipital encephalocele (HP:0002085)1.45784625
161Abnormality of monocarboxylic acid metabolism (HP:0010996)1.45601712
162Restrictive lung disease (HP:0002091)1.45475643
163Vaginal atresia (HP:0000148)1.44616225
164Pancreatic cysts (HP:0001737)1.43584592
165Focal motor seizures (HP:0011153)1.41604733
166Poor coordination (HP:0002370)1.40581514
167Preaxial hand polydactyly (HP:0001177)1.40085561
168Aplasia/Hypoplasia of the lens (HP:0008063)1.39670156
169Hemiparesis (HP:0001269)1.36474716
170Abnormality of renal excretion (HP:0011036)1.28628950
171Focal seizures (HP:0007359)1.27809930
172Absent epiphyses (HP:0010577)1.27771362
173Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.27771362
174Impaired vibratory sensation (HP:0002495)1.25074993
175Spastic tetraparesis (HP:0001285)1.25052926
176Pachygyria (HP:0001302)1.24920447
177Anencephaly (HP:0002323)1.23843717
178Impaired vibration sensation in the lower limbs (HP:0002166)1.22671254

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK37.97202874
2PDK47.97202874
3PDK25.01583750
4PNCK4.45763366
5PRKD33.75730084
6MAP4K13.68820615
7TESK13.17379167
8ICK2.71969488
9PRPF4B2.65711378
10BLK2.63812573
11PTK2B2.35566256
12TYK22.31519347
13MAPK152.22098176
14WNK42.02988003
15CSK1.98639236
16ZAP701.97635253
17NTRK31.88205336
18GRK61.85030367
19STK391.84650764
20TRIB31.84526513
21ERN11.84015064
22MAP2K31.77796336
23MAP3K131.74865735
24TXK1.67482903
25BTK1.67091272
26NTRK21.65563510
27JAK11.57204003
28EPHB11.56083691
29IKBKE1.55852426
30MAP3K141.53996655
31MAP3K71.43886646
32JAK31.42401692
33MAP3K41.42253049
34TAOK31.40564604
35TBK11.38447043
36NEK21.38424078
37TYRO31.35021095
38SYK1.34177517
39ITK1.33847927
40IRAK41.33042077
41MAP3K31.31460945
42HCK1.30569817
43STK381.28624333
44CCNB11.26823775
45FGFR31.24951960
46CAMK1G1.23480927
47FGFR41.22627085
48MAP3K91.18403234
49BMPR1B1.11099666
50WNK11.09739240
51LCK1.08870720
52TAOK11.07056979
53KIT1.06705519
54MAP2K71.06130311
55TEC1.05515154
56EPHA41.03420350
57EEF2K1.00797602
58SMG10.99981289
59HIPK20.99888871
60CDC70.99366022
61LMTK20.98155121
62LYN0.95267981
63NLK0.94412613
64JAK20.94136852
65MAP3K20.93999461
66MAPK120.92826859
67CSF1R0.90997933
68MAPK70.87828449
69WEE10.87083741
70BMPR20.87034580
71MAP3K10.86506154
72MARK10.84870984
73TRPM70.81539248
74STK100.80798934
75MAP3K100.80695205
76IKBKB0.80042723
77MARK30.79619302
78SGK30.79517362
79KSR20.79483435
80PASK0.77212476
81MAP3K60.76502953
82TNIK0.75348339
83PRKD20.75030232
84RET0.71926722
85DYRK30.71842864
86FGR0.70256988
87PDK10.70153485
88PINK10.69307971
89BRD40.69122306
90MAP2K40.68882896
91SIK10.68579647
92EPHA30.67261123
93MAP3K120.65851462
94PRKCQ0.64951221
95DYRK1B0.64630340
96CAMKK20.63114879
97MINK10.62805120
98PIK3CG0.62387286
99PAK60.62257432
100MAP3K110.62187990
101CDK60.59238851
102PRKCG0.59144411
103RIPK10.58853801
104MAPK110.57669383
105CAMKK10.57295687
106WNK30.56894469
107FYN0.56290262
108SIK30.55505865
109PTK60.54641793
110CHUK0.53367976
111RPS6KA20.52947242
112PRKCH0.52061508
113LRRK20.51653712
114RPS6KL10.50775970
115RPS6KC10.50775970
116PDGFRB0.50479444
117MELK0.49791341
118CDK190.49157290
119SGK4940.48018404
120SGK2230.48018404
121PRKAA20.47810682
122IRAK10.46841210
123MAPK130.46565879
124CHEK10.45808307
125ATR0.45371612
126MUSK0.42318474
127CAMK10.42296430
128CDK30.41619855
129RIPK40.39020587
130IRAK20.38654890
131CDK50.37804965
132CASK0.37666959
133NEK60.36996396
134MARK20.36298564
135PAK20.35477679
136CAMK2A0.34289127
137ATM0.30766954
138TNK20.30388772
139SIK20.29585464
140STK110.27314520
141STK30.26765288
142FGFR20.26212503
143FES0.25808204
144RPS6KB10.25707864
145CDK180.24035105
146CDK120.23579936
147CDK150.22896385
148UHMK10.22486042
149CHEK20.19988418
150RPS6KA30.18930709
151MAPK100.18913802
152MAPKAPK50.18879511
153MTOR0.18428044
154CDK140.18060167
155CDK11A0.17911656
156TTK0.17079414
157BRAF0.16124086
158PRKDC0.14586143
159GSK3B0.14552662
160MAP2K60.14309311
161PDPK10.14305932
162PRKAA10.13989351
163KSR10.13855895
164PLK20.12913955
165SGK10.12629809
166CDC42BPA0.12557479
167PRKACB0.12196889
168MAPK80.11925174
169ARAF0.11700841
170PLK10.11206988
171PRKG10.10919957
172PAK30.10822555
173CSNK1E0.10456974
174PRKACG0.10311835
175PRKCB0.09727938
176CDK10.09538751
177BCR0.08469932
178PRKACA0.08070166
179SGK20.07583527

Predicted pathways (KEGG)

RankGene SetZ-score
1Dorso-ventral axis formation_Homo sapiens_hsa043203.07098062
2Nicotine addiction_Homo sapiens_hsa050333.04949317
3Vitamin B6 metabolism_Homo sapiens_hsa007502.89710488
4Amphetamine addiction_Homo sapiens_hsa050312.88147878
5Pyruvate metabolism_Homo sapiens_hsa006202.83602939
6Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.44781307
7Glucagon signaling pathway_Homo sapiens_hsa049222.41645523
8Renin secretion_Homo sapiens_hsa049242.26811269
9Oocyte meiosis_Homo sapiens_hsa041142.23968973
10Long-term potentiation_Homo sapiens_hsa047202.14832279
11Osteoclast differentiation_Homo sapiens_hsa043802.10467117
12B cell receptor signaling pathway_Homo sapiens_hsa046622.10343562
13Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.09092804
14Circadian entrainment_Homo sapiens_hsa047132.08128592
15Staphylococcus aureus infection_Homo sapiens_hsa051502.07642564
16Leishmaniasis_Homo sapiens_hsa051402.02357827
17Synaptic vesicle cycle_Homo sapiens_hsa047211.98838974
18Huntingtons disease_Homo sapiens_hsa050161.96788792
19Fatty acid biosynthesis_Homo sapiens_hsa000611.96055373
20Graft-versus-host disease_Homo sapiens_hsa053321.86194448
21Morphine addiction_Homo sapiens_hsa050321.85942310
22Glutamatergic synapse_Homo sapiens_hsa047241.83819569
23Taste transduction_Homo sapiens_hsa047421.82400568
24Olfactory transduction_Homo sapiens_hsa047401.81103947
25Fanconi anemia pathway_Homo sapiens_hsa034601.79523489
26Allograft rejection_Homo sapiens_hsa053301.78699946
27Primary immunodeficiency_Homo sapiens_hsa053401.74719726
28Acute myeloid leukemia_Homo sapiens_hsa052211.72508301
29T cell receptor signaling pathway_Homo sapiens_hsa046601.72082217
30Autoimmune thyroid disease_Homo sapiens_hsa053201.69919855
31Propanoate metabolism_Homo sapiens_hsa006401.67452865
32GABAergic synapse_Homo sapiens_hsa047271.64092627
33Basal transcription factors_Homo sapiens_hsa030221.62410248
34Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.61638519
35Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.59487935
36Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.58088844
37Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.55413126
38Cocaine addiction_Homo sapiens_hsa050301.54893755
39Calcium signaling pathway_Homo sapiens_hsa040201.51438236
40Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.50115493
41Insulin secretion_Homo sapiens_hsa049111.49429193
42Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.48780765
43Estrogen signaling pathway_Homo sapiens_hsa049151.43090531
44Salivary secretion_Homo sapiens_hsa049701.42464160
45Other glycan degradation_Homo sapiens_hsa005111.41873824
46Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.41556031
47Dopaminergic synapse_Homo sapiens_hsa047281.40350861
48Toll-like receptor signaling pathway_Homo sapiens_hsa046201.37867084
49Tuberculosis_Homo sapiens_hsa051521.37687818
50NF-kappa B signaling pathway_Homo sapiens_hsa040641.37121995
51Hematopoietic cell lineage_Homo sapiens_hsa046401.37031109
52Cardiac muscle contraction_Homo sapiens_hsa042601.36378369
53Gastric acid secretion_Homo sapiens_hsa049711.35921501
54Jak-STAT signaling pathway_Homo sapiens_hsa046301.33190492
55Intestinal immune network for IgA production_Homo sapiens_hsa046721.29835881
56Type I diabetes mellitus_Homo sapiens_hsa049401.26475505
57Measles_Homo sapiens_hsa051621.26310043
58Non-small cell lung cancer_Homo sapiens_hsa052231.25871782
59Toxoplasmosis_Homo sapiens_hsa051451.25050213
60NOD-like receptor signaling pathway_Homo sapiens_hsa046211.24808676
61Glycerolipid metabolism_Homo sapiens_hsa005611.22310851
62Influenza A_Homo sapiens_hsa051641.22138418
63RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.22120287
64Collecting duct acid secretion_Homo sapiens_hsa049661.21736896
65Chemokine signaling pathway_Homo sapiens_hsa040621.20143891
66Platelet activation_Homo sapiens_hsa046111.17186790
67Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.16481517
68Aldosterone synthesis and secretion_Homo sapiens_hsa049251.16454546
69Carbohydrate digestion and absorption_Homo sapiens_hsa049731.15868218
70alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.15305005
71mRNA surveillance pathway_Homo sapiens_hsa030151.13041453
72TNF signaling pathway_Homo sapiens_hsa046681.12973968
73Leukocyte transendothelial migration_Homo sapiens_hsa046701.12944583
74Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.12580260
75Oxytocin signaling pathway_Homo sapiens_hsa049211.11487378
76Choline metabolism in cancer_Homo sapiens_hsa052311.11261310
77Notch signaling pathway_Homo sapiens_hsa043301.10769196
78Malaria_Homo sapiens_hsa051441.10387099
79Glycerophospholipid metabolism_Homo sapiens_hsa005641.07491400
80cAMP signaling pathway_Homo sapiens_hsa040241.07135144
81Pentose phosphate pathway_Homo sapiens_hsa000301.05058528
82Hepatitis C_Homo sapiens_hsa051601.04473749
83Asthma_Homo sapiens_hsa053101.02989219
84Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.01477948
85Linoleic acid metabolism_Homo sapiens_hsa005911.01468972
86Chronic myeloid leukemia_Homo sapiens_hsa052201.00316301
87Hedgehog signaling pathway_Homo sapiens_hsa043400.99522327
88Viral myocarditis_Homo sapiens_hsa054160.98747828
89Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.97727267
90cGMP-PKG signaling pathway_Homo sapiens_hsa040220.96952345
91Pancreatic cancer_Homo sapiens_hsa052120.95863722
92Histidine metabolism_Homo sapiens_hsa003400.95126631
93AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.92646959
94Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.91363286
95Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.91244726
96Herpes simplex infection_Homo sapiens_hsa051680.90580732
97Neurotrophin signaling pathway_Homo sapiens_hsa047220.90087741
98Hepatitis B_Homo sapiens_hsa051610.88339111
99Phosphatidylinositol signaling system_Homo sapiens_hsa040700.87484364
100Selenocompound metabolism_Homo sapiens_hsa004500.86518709
101Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.84894296
102Prolactin signaling pathway_Homo sapiens_hsa049170.84635178
103Alcoholism_Homo sapiens_hsa050340.83513825
104Insulin resistance_Homo sapiens_hsa049310.82491392
105mTOR signaling pathway_Homo sapiens_hsa041500.81605031
106Pertussis_Homo sapiens_hsa051330.79196733
107Complement and coagulation cascades_Homo sapiens_hsa046100.78993147
108Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.78849576
109Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.78312239
110Thyroid hormone synthesis_Homo sapiens_hsa049180.78298339
111Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.77652513
112Wnt signaling pathway_Homo sapiens_hsa043100.77112794
113Cholinergic synapse_Homo sapiens_hsa047250.75926806
114Serotonergic synapse_Homo sapiens_hsa047260.75117853
115Chemical carcinogenesis_Homo sapiens_hsa052040.74119726
116Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.73900396
117Melanogenesis_Homo sapiens_hsa049160.73856789
118Endometrial cancer_Homo sapiens_hsa052130.73083682
119Adipocytokine signaling pathway_Homo sapiens_hsa049200.72833251
120Glycosaminoglycan degradation_Homo sapiens_hsa005310.72571590
121Ether lipid metabolism_Homo sapiens_hsa005650.72171994
122Purine metabolism_Homo sapiens_hsa002300.71083271
123Axon guidance_Homo sapiens_hsa043600.71043094
124FoxO signaling pathway_Homo sapiens_hsa040680.70731541
125Cysteine and methionine metabolism_Homo sapiens_hsa002700.70344561
126African trypanosomiasis_Homo sapiens_hsa051430.69828841
127Sphingolipid signaling pathway_Homo sapiens_hsa040710.69483868
128Renal cell carcinoma_Homo sapiens_hsa052110.69005885
129Phenylalanine metabolism_Homo sapiens_hsa003600.68652538
130Vascular smooth muscle contraction_Homo sapiens_hsa042700.68436618
131Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.67078841
132Apoptosis_Homo sapiens_hsa042100.66385541
133PPAR signaling pathway_Homo sapiens_hsa033200.65871157
134Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.65316242
135Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.63404198
136Amoebiasis_Homo sapiens_hsa051460.62096986
137RNA transport_Homo sapiens_hsa030130.61840231
138Basal cell carcinoma_Homo sapiens_hsa052170.61605424
139Gap junction_Homo sapiens_hsa045400.61055184
140Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.59979307
141Fructose and mannose metabolism_Homo sapiens_hsa000510.59410015
142Transcriptional misregulation in cancer_Homo sapiens_hsa052020.59266303
143Colorectal cancer_Homo sapiens_hsa052100.58050051
144Long-term depression_Homo sapiens_hsa047300.57175929
145Legionellosis_Homo sapiens_hsa051340.56810574
146Type II diabetes mellitus_Homo sapiens_hsa049300.55797729
147Vibrio cholerae infection_Homo sapiens_hsa051100.53964505
148Phagosome_Homo sapiens_hsa041450.53393549
149Prostate cancer_Homo sapiens_hsa052150.52821345
150Rheumatoid arthritis_Homo sapiens_hsa053230.49431430
151Inositol phosphate metabolism_Homo sapiens_hsa005620.48614132
152HTLV-I infection_Homo sapiens_hsa051660.47500269
153Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.47413127
154GnRH signaling pathway_Homo sapiens_hsa049120.46789588
155MAPK signaling pathway_Homo sapiens_hsa040100.46280759
156Lysosome_Homo sapiens_hsa041420.45735672
157Central carbon metabolism in cancer_Homo sapiens_hsa052300.45148651
158VEGF signaling pathway_Homo sapiens_hsa043700.43557114
159Pancreatic secretion_Homo sapiens_hsa049720.42239534
160Phototransduction_Homo sapiens_hsa047440.41961242
161Antigen processing and presentation_Homo sapiens_hsa046120.41467055
162Mineral absorption_Homo sapiens_hsa049780.37003725
163Thyroid hormone signaling pathway_Homo sapiens_hsa049190.35994578
164Ovarian steroidogenesis_Homo sapiens_hsa049130.33400268
165N-Glycan biosynthesis_Homo sapiens_hsa005100.32990904
166ABC transporters_Homo sapiens_hsa020100.31784732
167Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.31520082
168ErbB signaling pathway_Homo sapiens_hsa040120.31184402
169Bile secretion_Homo sapiens_hsa049760.29168948
170Phospholipase D signaling pathway_Homo sapiens_hsa040720.28062344
171Carbon metabolism_Homo sapiens_hsa012000.27882196
172Longevity regulating pathway - mammal_Homo sapiens_hsa042110.26950424
173AMPK signaling pathway_Homo sapiens_hsa041520.26747556
174Endocytosis_Homo sapiens_hsa041440.26552818

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »