DNAH10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Dyneins are microtubule-associated motor protein complexes composed of several heavy, light, and intermediate chains. The axonemal dyneins, found in cilia and flagella, are components of the outer and inner dynein arms attached to the peripheral microtubule doublets. DNAH10 is an inner arm dynein heavy chain (Maiti et al., 2000 [PubMed 11175280]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium movement (GO:0003341)9.97587732
2sperm-egg recognition (GO:0035036)9.29302941
3epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)9.10711291
4plasma membrane fusion (GO:0045026)9.04528959
5acrosome assembly (GO:0001675)8.73515645
6acrosome reaction (GO:0007340)8.62129147
7binding of sperm to zona pellucida (GO:0007339)8.41283106
8male meiosis (GO:0007140)8.35044920
9cell-cell recognition (GO:0009988)8.29557938
10reproduction (GO:0000003)8.21646674
11cell wall macromolecule catabolic process (GO:0016998)8.10703265
12cell wall macromolecule metabolic process (GO:0044036)8.10703265
13spermatid development (GO:0007286)7.83062427
14regulation of cilium movement (GO:0003352)7.29440606
15synaptonemal complex organization (GO:0070193)7.24048411
16synaptonemal complex assembly (GO:0007130)6.88602097
17single fertilization (GO:0007338)6.84332432
18DNA methylation involved in gamete generation (GO:0043046)6.61311257
19ventricular system development (GO:0021591)6.49769346
20fertilization (GO:0009566)5.97795599
21primary alcohol catabolic process (GO:0034310)5.95065188
22male meiosis I (GO:0007141)5.82353777
23vitamin transmembrane transport (GO:0035461)5.74589126
24negative regulation of inclusion body assembly (GO:0090084)5.64660254
25sperm capacitation (GO:0048240)5.59848506
26microtubule depolymerization (GO:0007019)5.30752899
27spermatogenesis (GO:0007283)5.21002017
28male gamete generation (GO:0048232)5.19371637
29meiotic cell cycle (GO:0051321)5.02661710
30ethanol metabolic process (GO:0006067)4.99849335
31chromosome organization involved in meiosis (GO:0070192)4.95283151
32meiotic nuclear division (GO:0007126)4.92065218
33gamete generation (GO:0007276)4.85899684
34microtubule severing (GO:0051013)4.80427994
35meiosis I (GO:0007127)4.76888540
36diterpenoid biosynthetic process (GO:0016102)4.75440942
37germ cell development (GO:0007281)4.72719193
38pyrimidine-containing compound transmembrane transport (GO:0072531)4.70696792
39cellular process involved in reproduction in multicellular organism (GO:0022412)4.67703025
40response to xenobiotic stimulus (GO:0009410)4.65956087
41intraciliary transport (GO:0042073)4.46533634
42axoneme assembly (GO:0035082)4.46419837
43left/right pattern formation (GO:0060972)4.46048163
44regulation of microtubule-based movement (GO:0060632)4.44227211
45protein localization to cilium (GO:0061512)4.40364005
46regulation of interleukin-5 production (GO:0032674)4.29213402
47cell recognition (GO:0008037)4.24048346
48one-carbon compound transport (GO:0019755)4.22389014
49lateral ventricle development (GO:0021670)4.21257388
50regulation of inclusion body assembly (GO:0090083)4.19374683
51calcium ion-dependent exocytosis (GO:0017156)4.13066898
52glomerular epithelial cell development (GO:0072310)4.11964402
53gene silencing by RNA (GO:0031047)3.98266280
54lung epithelium development (GO:0060428)3.94612918
55monoubiquitinated protein deubiquitination (GO:0035520)3.92550915
56regulation of interleukin-13 production (GO:0032656)3.92387582
57tolerance induction (GO:0002507)3.91616373
58seminiferous tubule development (GO:0072520)3.90593248
59cilium organization (GO:0044782)3.86780967
60* microtubule-based movement (GO:0007018)3.86691195
61negative regulation of immunoglobulin mediated immune response (GO:0002890)3.85575082
62negative regulation of B cell mediated immunity (GO:0002713)3.85575082
63multicellular organismal reproductive process (GO:0048609)3.81465729
64cytoplasmic microtubule organization (GO:0031122)3.81260708
65regulation of centriole replication (GO:0046599)3.80103315
66centriole assembly (GO:0098534)3.79872340
67centriole replication (GO:0007099)3.78187533
68negative regulation of humoral immune response (GO:0002921)3.76256401
69regulation of meiosis I (GO:0060631)3.75500254
70negative regulation of T cell differentiation in thymus (GO:0033085)3.73550107
71cilium assembly (GO:0042384)3.73004748
72retinal cone cell development (GO:0046549)3.71666033
73organic cation transport (GO:0015695)3.70988787
74establishment of apical/basal cell polarity (GO:0035089)3.66693933
75negative regulation of organelle assembly (GO:1902116)3.64988485
76left/right axis specification (GO:0070986)3.64724586
77regulation of germinal center formation (GO:0002634)3.61045692
78ethanol oxidation (GO:0006069)3.58457280
79protein polyglutamylation (GO:0018095)3.56800734
80regulation of protein polyubiquitination (GO:1902914)3.51663544
81cilium morphogenesis (GO:0060271)3.49965110
82genitalia morphogenesis (GO:0035112)3.48338212
83establishment or maintenance of monopolar cell polarity (GO:0061339)3.40282974
84establishment of monopolar cell polarity (GO:0061162)3.40282974
85negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.37865840
86cellular component assembly involved in morphogenesis (GO:0010927)3.36528376
87meiotic cell cycle process (GO:1903046)3.32471018
88determination of left/right symmetry (GO:0007368)3.26820514
89retinoic acid metabolic process (GO:0042573)3.26407750
90retinal rod cell development (GO:0046548)3.24452426
91positive regulation of tolerance induction (GO:0002645)3.21321553
92phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.18773870
93mitotic sister chromatid cohesion (GO:0007064)3.17414495
94microtubule polymerization or depolymerization (GO:0031109)3.14514723
95determination of bilateral symmetry (GO:0009855)3.13323059
96synapsis (GO:0007129)3.12317732
97specification of symmetry (GO:0009799)3.06103481
98establishment of tissue polarity (GO:0007164)3.05550997
99establishment of planar polarity (GO:0001736)3.05550997
100terpenoid biosynthetic process (GO:0016114)3.04587321
101nuclear pore complex assembly (GO:0051292)3.03241307
102regulation of microtubule depolymerization (GO:0031114)3.01210128
103multicellular organismal development (GO:0007275)2.97910993
104positive regulation of smoothened signaling pathway (GO:0045880)2.97052938
105spermatid nucleus differentiation (GO:0007289)2.95044561
106smoothened signaling pathway (GO:0007224)2.94811272
107exogenous drug catabolic process (GO:0042738)2.94121221
108O-glycan processing (GO:0016266)2.93558744
109microtubule bundle formation (GO:0001578)2.90147707
110nucleoside diphosphate phosphorylation (GO:0006165)2.88498082
111DNA alkylation (GO:0006305)2.85265529
112DNA methylation (GO:0006306)2.85265529
113regulation of spindle checkpoint (GO:0090231)2.84441087
114photoreceptor cell maintenance (GO:0045494)2.79834745
115gene silencing (GO:0016458)2.75276918
116glutathione derivative biosynthetic process (GO:1901687)2.69809057
117glutathione derivative metabolic process (GO:1901685)2.69809057
118sister chromatid cohesion (GO:0007062)2.67886622
119regulation of acrosome reaction (GO:0060046)2.67049687
120chaperone-mediated protein complex assembly (GO:0051131)2.66080963
121apical protein localization (GO:0045176)2.62279557
122chromosome condensation (GO:0030261)2.61829506
123lateral sprouting from an epithelium (GO:0060601)2.60959846
124DNA packaging (GO:0006323)2.58604967
125alditol metabolic process (GO:0019400)2.58149730
126single strand break repair (GO:0000012)2.55465263
127lactate metabolic process (GO:0006089)2.54201018
128glutathione metabolic process (GO:0006749)2.54088853
129protein refolding (GO:0042026)2.53174940
130carnitine metabolic process (GO:0009437)2.51265218
131primary alcohol metabolic process (GO:0034308)2.50640423
132GTP biosynthetic process (GO:0006183)2.50473472
133nucleus organization (GO:0006997)2.49714603
134amino-acid betaine transport (GO:0015838)2.49583236
135carnitine transport (GO:0015879)2.49583236
136* microtubule-based process (GO:0007017)2.47943720
137carnitine transmembrane transport (GO:1902603)2.46553762
138heart looping (GO:0001947)2.45984530
139negative regulation of microtubule depolymerization (GO:0007026)2.45762026
140regulation of histone H3-K9 methylation (GO:0051570)2.45590034
141cell projection assembly (GO:0030031)2.45536821
142regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.44101209
143phosphatidylcholine biosynthetic process (GO:0006656)2.42134421
144organelle assembly (GO:0070925)2.41617400
145embryonic camera-type eye development (GO:0031076)2.40191012
146retinol metabolic process (GO:0042572)2.40001559
147phosphatidylethanolamine biosynthetic process (GO:0006646)2.37614679
148excretion (GO:0007588)2.36990580
149drug catabolic process (GO:0042737)2.34359417
150leukotriene biosynthetic process (GO:0019370)2.31887391
151regulation of female gonad development (GO:2000194)2.31656103
152CDP-diacylglycerol biosynthetic process (GO:0016024)2.31577221
153multicellular organismal water homeostasis (GO:0050891)2.31104138
154hydrogen peroxide biosynthetic process (GO:0050665)2.30395313
155regulation of smoothened signaling pathway (GO:0008589)2.30316818
156hypotonic response (GO:0006971)2.28724049
157regulation of cilium assembly (GO:1902017)2.26904869
158regulation of response to osmotic stress (GO:0047484)2.23916149
159cilium or flagellum-dependent cell motility (GO:0001539)16.8138655
160fusion of sperm to egg plasma membrane (GO:0007342)11.7741188
161axonemal dynein complex assembly (GO:0070286)11.7056093
162piRNA metabolic process (GO:0034587)10.3175061
163multicellular organism reproduction (GO:0032504)10.2205426
164epithelial cilium movement (GO:0003351)10.1529960
165motile cilium assembly (GO:0044458)10.1464535
166sperm motility (GO:0030317)10.0913610

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse8.64703538
2EZH2_22144423_ChIP-Seq_EOC_Human5.73483301
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.26670595
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.73072653
5DROSHA_22980978_ChIP-Seq_HELA_Human3.39155920
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.29271980
7FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.70877820
8PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.32247800
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.28100591
10STAT6_21828071_ChIP-Seq_BEAS2B_Human2.24678010
11ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.19006932
12AHR_22903824_ChIP-Seq_MCF-7_Human2.15733990
13PIAS1_25552417_ChIP-Seq_VCAP_Human2.12457924
14PCGF2_27294783_Chip-Seq_ESCs_Mouse2.12059536
15GATA1_26923725_Chip-Seq_HPCs_Mouse2.01301210
16ARNT_22903824_ChIP-Seq_MCF-7_Human1.97028092
17TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.95120934
18ESR1_20079471_ChIP-ChIP_T-47D_Human1.94985394
19CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.87921506
20FOXM1_26456572_ChIP-Seq_MCF-7_Human1.82074500
21ZNF217_24962896_ChIP-Seq_MCF-7_Human1.80152495
22GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.78408644
23NR3C1_21868756_ChIP-Seq_MCF10A_Human1.75235332
24EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.75075816
25PCGF2_27294783_Chip-Seq_NPCs_Mouse1.74726258
26KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.70071946
27FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.69047057
28TOP2B_26459242_ChIP-Seq_MCF-7_Human1.68705994
29ZNF274_21170338_ChIP-Seq_K562_Hela1.68188949
30ELK4_26923725_Chip-Seq_MESODERM_Mouse1.67396869
31NFE2_27457419_Chip-Seq_LIVER_Mouse1.67026862
32CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.66842705
33SUZ12_27294783_Chip-Seq_NPCs_Mouse1.63904312
34TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.63411493
35GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.62818301
36KAP1_22055183_ChIP-Seq_ESCs_Mouse1.62506347
37PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.61994358
38WDR5_24793694_ChIP-Seq_LNCAP_Human1.61655211
39TP63_23658742_ChIP-Seq_EP156T_Human1.61591953
40MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.61050664
41CBX2_27304074_Chip-Seq_ESCs_Mouse1.59015999
42TP53_18474530_ChIP-ChIP_U2OS_Human1.57648570
43AR_21572438_ChIP-Seq_LNCaP_Human1.54984814
44GBX2_23144817_ChIP-Seq_PC3_Human1.54093323
45SALL1_21062744_ChIP-ChIP_HESCs_Human1.53912442
46VDR_22108803_ChIP-Seq_LS180_Human1.52258437
47ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.51485466
48TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.50149938
49TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.47972546
50TAL1_26923725_Chip-Seq_HPCs_Mouse1.47636496
51NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.46111142
52REST_21632747_ChIP-Seq_MESCs_Mouse1.45725073
53FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.43767361
54NANOG_18555785_Chip-Seq_ESCs_Mouse1.42341038
55ZFP57_27257070_Chip-Seq_ESCs_Mouse1.41192345
56TP53_16413492_ChIP-PET_HCT116_Human1.39796311
57* SMAD3_21741376_ChIP-Seq_EPCs_Human1.39391595
58CTBP2_25329375_ChIP-Seq_LNCAP_Human1.38414512
59SMRT_27268052_Chip-Seq_Bcells_Human1.37652154
60AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.37456575
61EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.36545806
62STAT1_17558387_ChIP-Seq_HELA_Human1.35919556
63* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.35607833
64ETV1_20927104_ChIP-Seq_GIST48_Human1.34456793
65IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.34434386
66CBP_20019798_ChIP-Seq_JUKART_Human1.34434386
67MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.34417290
68TRIM28_21343339_ChIP-Seq_HEK293_Human1.33927981
69KDM2B_26808549_Chip-Seq_REH_Human1.33878135
70POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.33419187
71TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33419187
72RNF2_27304074_Chip-Seq_NSC_Mouse1.32942990
73CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30585088
74EZH2_27294783_Chip-Seq_NPCs_Mouse1.30265713
75OCT4_18555785_Chip-Seq_ESCs_Mouse1.28886177
76TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27426651
77PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.26137098
78RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.26073865
79TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.25006674
80P53_22387025_ChIP-Seq_ESCs_Mouse1.23699546
81TCF4_23295773_ChIP-Seq_U87_Human1.23413694
82SMAD3_21741376_ChIP-Seq_HESCs_Human1.22519526
83CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.22052289
84CMYC_18555785_Chip-Seq_ESCs_Mouse1.21851535
85P300_18555785_Chip-Seq_ESCs_Mouse1.21678213
86STAT1_20625510_ChIP-Seq_HELA_Human1.21061003
87RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.20697802
88GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.20549736
89AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.19844588
90STAT3_18555785_Chip-Seq_ESCs_Mouse1.19111085
91KLF5_25053715_ChIP-Seq_YYC3_Human1.18837538
92SOX9_24532713_ChIP-Seq_HFSC_Mouse1.18772160
93SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.18526525
94KLF4_18555785_Chip-Seq_ESCs_Mouse1.18120680
95GF1_26923725_Chip-Seq_HPCs_Mouse1.17635342
96CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.17461717
97FUS_26573619_Chip-Seq_HEK293_Human1.17354444
98CRX_20693478_ChIP-Seq_RETINA_Mouse1.17341754
99EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.16901457
100SMAD4_21799915_ChIP-Seq_A2780_Human1.16841193
101ESRRB_18555785_Chip-Seq_ESCs_Mouse1.16513794
102ER_23166858_ChIP-Seq_MCF-7_Human1.15892321
103RUNX1_26923725_Chip-Seq_HPCs_Mouse1.15225831
104TBL1_22424771_ChIP-Seq_293T_Human1.15086372
105PHF8_20622853_ChIP-Seq_HELA_Human1.14303065
106FOXA1_25552417_ChIP-Seq_VCAP_Human1.13614548
107PRDM14_20953172_ChIP-Seq_ESCs_Human1.13610973
108E2F1_18555785_Chip-Seq_ESCs_Mouse1.13486019
109TCF4_22108803_ChIP-Seq_LS180_Human1.13311572
110SUZ12_18555785_Chip-Seq_ESCs_Mouse1.13217647
111AR_25329375_ChIP-Seq_VCAP_Human1.13169670
112PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.12141800
113FLI1_21867929_ChIP-Seq_TH2_Mouse1.11437396
114* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.10787332
115* RUNX2_22187159_ChIP-Seq_PCA_Human1.10519582
116TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.10081418
117HNFA_21074721_ChIP-Seq_CACO-2_Human1.09516668
118RUNX1_27514584_Chip-Seq_MCF-7_Human1.09024976
119STAT3_23295773_ChIP-Seq_U87_Human1.08923064
120CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.08552758
121OCT4_21477851_ChIP-Seq_ESCs_Mouse1.08547874
122MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.07952548
123CBX2_22325352_ChIP-Seq_293T-Rex_Human1.07950655
124CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.07364850
125SMAD4_21741376_ChIP-Seq_HESCs_Human1.07067157
126RBPJ_21746931_ChIP-Seq_IB4_Human1.05888261
127CTBP1_25329375_ChIP-Seq_LNCAP_Human1.05608952
128FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05226064
129NFYA_21822215_ChIP-Seq_K562_Human1.05184340
130NFYB_21822215_ChIP-Seq_K562_Human1.04163457
131CDX2_19796622_ChIP-Seq_MESCs_Mouse1.03997136
132CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.02831422
133ZFX_18555785_Chip-Seq_ESCs_Mouse1.02702688
134SOX2_18555785_Chip-Seq_ESCs_Mouse1.02192231
135SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.02147549
136PU1_27457419_Chip-Seq_LIVER_Mouse1.01797744
137BCAT_22108803_ChIP-Seq_LS180_Human1.01613750
138CTCF_18555785_Chip-Seq_ESCs_Mouse1.01546107
139GF1B_26923725_Chip-Seq_HPCs_Mouse1.00842160
140FOXO3_23340844_ChIP-Seq_DLD1_Human1.00446941
141RUNX1_27457419_Chip-Seq_LIVER_Mouse0.99807279
142SOX2_27498859_Chip-Seq_STOMACH_Mouse0.99611526
143ESR2_21235772_ChIP-Seq_MCF-7_Human0.99486592
144TAF15_26573619_Chip-Seq_HEK293_Human0.99002875
145NMYC_18555785_Chip-Seq_ESCs_Mouse0.98948499
146RXR_22108803_ChIP-Seq_LS180_Human0.97751578
147PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.97722114
148CDX2_22108803_ChIP-Seq_LS180_Human0.97537449
149POU3F2_20337985_ChIP-ChIP_501MEL_Human0.97147556
150SMC4_20622854_ChIP-Seq_HELA_Human0.96886745
151AR_19668381_ChIP-Seq_PC3_Human0.96725119
152* SMAD4_21741376_ChIP-Seq_EPCs_Human0.96533081
153RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.94617864
154EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.94086812
155P300_19829295_ChIP-Seq_ESCs_Human0.94031417
156ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.93956473
157TP63_22573176_ChIP-Seq_HFKS_Human0.93488488
158LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.93474942
159SOX2_22085726_ChIP-Seq_NPCs_Mouse0.93305168
160OCT1_27270436_Chip-Seq_PROSTATE_Human0.92312131
161EZH2_27294783_Chip-Seq_ESCs_Mouse0.92132820
162FOXA2_19822575_ChIP-Seq_HepG2_Human0.91818530
163SMAD1_18555785_Chip-Seq_ESCs_Mouse0.91580005
164SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.91499546
165TDRD3_21172665_ChIP-Seq_MCF-7_Human0.90758122
166GATA1_19941826_ChIP-Seq_K562_Human0.89511671
167TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.89065377
168ESR1_21235772_ChIP-Seq_MCF-7_Human0.88812081
169EP300_21415370_ChIP-Seq_HL-1_Mouse0.88006235

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008875_abnormal_xenobiotic_pharmacok5.85949932
2MP0008877_abnormal_DNA_methylation5.39003240
3MP0003698_abnormal_male_reproductive5.37066086
4MP0001929_abnormal_gametogenesis5.10176160
5MP0002132_abnormal_respiratory_system5.09261249
6MP0002653_abnormal_ependyma_morphology4.83001363
7MP0002210_abnormal_sex_determination3.75790311
8MP0005623_abnormal_meninges_morphology3.64799379
9MP0004043_abnormal_pH_regulation3.61816223
10MP0008789_abnormal_olfactory_epithelium3.42132700
11MP0002277_abnormal_respiratory_mucosa3.38000448
12MP0001145_abnormal_male_reproductive3.08396269
13MP0002161_abnormal_fertility/fecundity3.06209854
14MP0009780_abnormal_chondrocyte_physiolo2.99086182
15MP0000653_abnormal_sex_gland2.83468311
16MP0000383_abnormal_hair_follicle2.55158095
17MP0005394_taste/olfaction_phenotype2.46135288
18MP0005499_abnormal_olfactory_system2.46135288
19MP0000566_synostosis2.36065547
20MP0010678_abnormal_skin_adnexa2.23611426
21MP0003656_abnormal_erythrocyte_physiolo2.11149140
22MP0002160_abnormal_reproductive_system2.03355184
23MP0005410_abnormal_fertilization12.3516723
24MP0008995_early_reproductive_senescence1.76599371
25MP0008057_abnormal_DNA_replication1.72860488
26MP0002734_abnormal_mechanical_nocicepti1.65826730
27MP0002282_abnormal_trachea_morphology1.64678948
28MP0009046_muscle_twitch1.64071878
29MP0003950_abnormal_plasma_membrane1.63514673
30MP0002735_abnormal_chemical_nociception1.62051247
31MP0004019_abnormal_vitamin_homeostasis1.60285838
32MP0000678_abnormal_parathyroid_gland1.51376640
33MP0003646_muscle_fatigue1.49790884
34MP0005647_abnormal_sex_gland1.48779339
35MP0005670_abnormal_white_adipose1.46683966
36MP0008058_abnormal_DNA_repair1.45993753
37MP0010094_abnormal_chromosome_stability1.37145788
38MP0002102_abnormal_ear_morphology1.35328492
39MP0005377_hearing/vestibular/ear_phenot1.32487863
40MP0003878_abnormal_ear_physiology1.32487863
41MP0002249_abnormal_larynx_morphology1.25263067
42MP0002822_catalepsy1.17599500
43MP0002909_abnormal_adrenal_gland1.17326647
44MP0005389_reproductive_system_phenotype1.16814549
45MP0005083_abnormal_biliary_tract1.16794947
46MP0010234_abnormal_vibrissa_follicle1.12243312
47MP0000465_gastrointestinal_hemorrhage1.11294294
48MP0005248_abnormal_Harderian_gland1.07307105
49MP0003111_abnormal_nucleus_morphology1.05797488
50MP0005409_darkened_coat_color1.02037082
51MP0005220_abnormal_exocrine_pancreas0.97334960
52MP0003787_abnormal_imprinting0.95515827
53MP0003786_premature_aging0.92147443
54MP0000681_abnormal_thyroid_gland0.91122917
55MP0010030_abnormal_orbit_morphology0.90542284
56MP0002638_abnormal_pupillary_reflex0.90460670
57MP0003699_abnormal_female_reproductive0.88882231
58MP0005636_abnormal_mineral_homeostasis0.85716670
59MP0003183_abnormal_peptide_metabolism0.83157947
60MP0005085_abnormal_gallbladder_physiolo0.83105958
61MP0003136_yellow_coat_color0.82890629
62MP0000569_abnormal_digit_pigmentation0.82758445
63MP0001293_anophthalmia0.82577333
64MP0005503_abnormal_tendon_morphology0.82403610
65MP0008007_abnormal_cellular_replicative0.81357479
66MP0001485_abnormal_pinna_reflex0.80816594
67MP0001502_abnormal_circadian_rhythm0.78388020
68MP0001984_abnormal_olfaction0.78099812
69MP0004133_heterotaxia0.77781906
70MP0001119_abnormal_female_reproductive0.77388132
71MP0001879_abnormal_lymphatic_vessel0.76101190
72MP0005310_abnormal_salivary_gland0.74347784
73MP0001970_abnormal_pain_threshold0.73299267
74MP0008004_abnormal_stomach_pH0.73159504
75MP0001765_abnormal_ion_homeostasis0.72171689
76MP0003195_calcinosis0.71530315
77MP0003879_abnormal_hair_cell0.71459510
78MP0001664_abnormal_digestion0.71195222
79MP0010368_abnormal_lymphatic_system0.70110135
80MP0004742_abnormal_vestibular_system0.69251673
81MP0003718_maternal_effect0.68967475
82MP0005646_abnormal_pituitary_gland0.66564555
83MP0005187_abnormal_penis_morphology0.66475160
84MP0001324_abnormal_eye_pigmentation0.65930346
85MP0005164_abnormal_response_to0.65144887
86MP0000049_abnormal_middle_ear0.64825329
87MP0003861_abnormal_nervous_system0.63506754
88MP0005408_hypopigmentation0.62665106
89MP0003077_abnormal_cell_cycle0.62510597
90MP0001851_eye_inflammation0.62496872
91MP0003045_fibrosis0.62227875
92MP0002928_abnormal_bile_duct0.62226039
93MP0003315_abnormal_perineum_morphology0.61891041
94MP0004883_abnormal_blood_vessel0.61820111
95MP0001486_abnormal_startle_reflex0.61677472
96MP0005551_abnormal_eye_electrophysiolog0.61653400
97MP0003937_abnormal_limbs/digits/tail_de0.61529671
98MP0001963_abnormal_hearing_physiology0.59366249
99MP0002136_abnormal_kidney_physiology0.59131354
100MP0002084_abnormal_developmental_patter0.59073979
101MP0001727_abnormal_embryo_implantation0.58893417
102MP0005451_abnormal_body_composition0.58138795
103MP0009745_abnormal_behavioral_response0.55907975
104MP0005195_abnormal_posterior_eye0.55814831
105MP0003115_abnormal_respiratory_system0.55776175
106MP0004233_abnormal_muscle_weight0.55534370
107MP0001440_abnormal_grooming_behavior0.55425396
108MP0001270_distended_abdomen0.55376186
109MP0002139_abnormal_hepatobiliary_system0.55038425
110MP0002272_abnormal_nervous_system0.54320937
111MP0001968_abnormal_touch/_nociception0.53952107
112MP0009379_abnormal_foot_pigmentation0.53801711
113MP0005165_increased_susceptibility_to0.53517984
114MP0002152_abnormal_brain_morphology0.53245173
115MP0009643_abnormal_urine_homeostasis0.53042213
116MP0005253_abnormal_eye_physiology0.52111947
117MP0003252_abnormal_bile_duct0.52046037
118MP0000462_abnormal_digestive_system0.51528674
119MP0000613_abnormal_salivary_gland0.50958371
120MP0003890_abnormal_embryonic-extraembry0.50276763
121MP0005395_other_phenotype0.49320559
122MP0001730_embryonic_growth_arrest0.49101821
123MP0004134_abnormal_chest_morphology0.48901313
124MP0000647_abnormal_sebaceous_gland0.48722769
125MP0000026_abnormal_inner_ear0.48496729
126MP0000631_abnormal_neuroendocrine_gland0.47895008
127MP0002234_abnormal_pharynx_morphology0.47408420
128MP0000778_abnormal_nervous_system0.47034191
129MP0004270_analgesia0.46091799
130MP0003942_abnormal_urinary_system0.44167819
131MP0006072_abnormal_retinal_apoptosis0.42010714
132MP0009250_abnormal_appendicular_skeleto0.41930649
133MP0002168_other_aberrant_phenotype0.41675884
134MP0002085_abnormal_embryonic_tissue0.41663886
135MP0005666_abnormal_adipose_tissue0.41647241
136MP0001346_abnormal_lacrimal_gland0.41066955
137MP0000432_abnormal_head_morphology0.40880659
138MP0002876_abnormal_thyroid_physiology0.40276808
139MP0002233_abnormal_nose_morphology0.39944235
140MP0005423_abnormal_somatic_nervous0.39321142
141MP0000427_abnormal_hair_cycle0.39247345
142MP0002752_abnormal_somatic_nervous0.39021102
143MP0004859_abnormal_synaptic_plasticity0.39018383
144MP0002116_abnormal_craniofacial_bone0.37976502
145MP0005391_vision/eye_phenotype0.37329203
146MP0000955_abnormal_spinal_cord0.36686291
147MP0003936_abnormal_reproductive_system0.35914751
148MP0002229_neurodegeneration0.35832808
149MP0000358_abnormal_cell_content/0.35576329
150MP0005397_hematopoietic_system_phenotyp0.35538309
151MP0001545_abnormal_hematopoietic_system0.35538309
152MP0002572_abnormal_emotion/affect_behav0.35292307
153MP0010307_abnormal_tumor_latency0.34709736
154MP0001661_extended_life_span0.34511483
155MP0005388_respiratory_system_phenotype0.34263194
156MP0002133_abnormal_respiratory_system0.34263194
157MP0002882_abnormal_neuron_morphology0.33906406
158MP0002557_abnormal_social/conspecific_i0.33615577

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.72856735
2Abnormal respiratory motile cilium morphology (HP:0005938)8.63020272
3Abnormal respiratory epithelium morphology (HP:0012253)8.63020272
4Abnormal ciliary motility (HP:0012262)8.35520960
5Rhinitis (HP:0012384)8.09617136
6Chronic bronchitis (HP:0004469)6.89141014
7Nasal polyposis (HP:0100582)5.89339856
8Infertility (HP:0000789)5.85871669
9Abnormality of the nasal mucosa (HP:0000433)4.99844262
10Bronchiectasis (HP:0002110)4.82896460
11Male infertility (HP:0003251)4.28059284
12Nephronophthisis (HP:0000090)4.20749310
13Bronchitis (HP:0012387)4.06839315
14Tubulointerstitial nephritis (HP:0001970)3.40461942
15Abnormality of the renal medulla (HP:0100957)3.33301948
16Recurrent otitis media (HP:0000403)2.95820578
17Recurrent sinusitis (HP:0011108)2.88441296
18Chronic otitis media (HP:0000389)2.87591202
19Abnormality of the lower motor neuron (HP:0002366)2.80627590
20Hyperactive renin-angiotensin system (HP:0000841)2.77256247
21Medial flaring of the eyebrow (HP:0010747)2.72787372
22Atelectasis (HP:0100750)2.69902800
23Abnormality of midbrain morphology (HP:0002418)2.64110460
24Molar tooth sign on MRI (HP:0002419)2.64110460
25Impulsivity (HP:0100710)2.42497585
26Tubulointerstitial abnormality (HP:0001969)2.41744865
27Postaxial foot polydactyly (HP:0001830)2.38057159
28Supernumerary spleens (HP:0009799)2.37828121
29Amyotrophic lateral sclerosis (HP:0007354)2.35776859
30Abnormal spermatogenesis (HP:0008669)2.35609503
31Abnormality of dentin (HP:0010299)2.32073562
32Gonadotropin excess (HP:0000837)2.30374822
33Tubular atrophy (HP:0000092)2.23971120
34Fibular hypoplasia (HP:0003038)2.19656351
35Recurrent bronchitis (HP:0002837)2.18638183
36Stage 5 chronic kidney disease (HP:0003774)2.12055746
37Congenital hepatic fibrosis (HP:0002612)2.08844312
38Abnormality of the dental root (HP:0006486)2.06613139
39Taurodontia (HP:0000679)2.06613139
40Abnormality of permanent molar morphology (HP:0011071)2.06613139
41Anencephaly (HP:0002323)2.02192099
42Pancreatic fibrosis (HP:0100732)2.02126164
43Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.1214075
44Dynein arm defect of respiratory motile cilia (HP:0012255)11.3322047
45Absent/shortened dynein arms (HP:0200106)11.3322047
46Hypoplasia of the capital femoral epiphysis (HP:0003090)1.97883654
47Azoospermia (HP:0000027)1.96536011
48Abnormality of molar (HP:0011077)1.96450463
49Abnormality of molar morphology (HP:0011070)1.96450463
50Gait imbalance (HP:0002141)1.94758079
51Congenital primary aphakia (HP:0007707)1.93217170
52Chronic sinusitis (HP:0011109)1.92298877
53Abnormality of the dental pulp (HP:0006479)1.90840818
54Decreased circulating renin level (HP:0003351)1.87299738
55Short ribs (HP:0000773)1.80404026
56Cystic liver disease (HP:0006706)1.79795255
57Facial cleft (HP:0002006)1.78917454
58True hermaphroditism (HP:0010459)1.78910043
59Aplasia/Hypoplasia of the tongue (HP:0010295)1.78497580
60Microglossia (HP:0000171)1.78164075
61Median cleft lip (HP:0000161)1.75858163
62Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.73806895
63Absent epiphyses (HP:0010577)1.73806895
64Abnormal biliary tract physiology (HP:0012439)1.73565031
65Bile duct proliferation (HP:0001408)1.73565031
66Postaxial hand polydactyly (HP:0001162)1.72855067
67Nephrogenic diabetes insipidus (HP:0009806)1.68164753
68Hyperkalemia (HP:0002153)1.67848373
69Oculomotor apraxia (HP:0000657)1.67830561
70Broad distal phalanx of finger (HP:0009836)1.66380650
71Tubulointerstitial fibrosis (HP:0005576)1.66129242
72Heterotopia (HP:0002282)1.65402414
73Cone-rod dystrophy (HP:0000548)1.63779578
74Sclerocornea (HP:0000647)1.62532643
75Furrowed tongue (HP:0000221)1.61128980
76Renal dysplasia (HP:0000110)1.59968595
77Absent rod-and cone-mediated responses on ERG (HP:0007688)1.59410309
78Absent frontal sinuses (HP:0002688)1.59195500
79Occipital encephalocele (HP:0002085)1.59130631
80Poor coordination (HP:0002370)1.58100433
81Genital tract atresia (HP:0001827)1.57242925
82Short thorax (HP:0010306)1.56678544
83Abnormality of the renal cortex (HP:0011035)1.56260856
84Nephropathy (HP:0000112)1.55924894
85Vaginal atresia (HP:0000148)1.54959231
86Aplasia/Hypoplasia of the spleen (HP:0010451)1.53277729
87Asplenia (HP:0001746)1.53244017
88Renal salt wasting (HP:0000127)1.51176811
89Pancreatic cysts (HP:0001737)1.49301707
90Papillary thyroid carcinoma (HP:0002895)1.48712172
91Bell-shaped thorax (HP:0001591)1.48684039
92Impaired proprioception (HP:0010831)1.45648249
93Hyperaldosteronism (HP:0000859)1.44566786
94Short nail (HP:0001799)1.42988920
95Aplasia/Hypoplasia of the fibula (HP:0006492)1.42046733
96Degeneration of the lateral corticospinal tracts (HP:0002314)1.41835482
97Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.41835482
98Upper motor neuron abnormality (HP:0002127)1.41351681
99Preaxial hand polydactyly (HP:0001177)1.41002225
100Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.39840684
101Male pseudohermaphroditism (HP:0000037)1.39337344
102Abnormal drinking behavior (HP:0030082)1.38890227
103Polydipsia (HP:0001959)1.38890227
104Spastic tetraparesis (HP:0001285)1.38537564
105Decreased motor nerve conduction velocity (HP:0003431)1.38388748
106Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.38095226
107Aplasia/Hypoplasia of the lens (HP:0008063)1.36372538
108Short femoral neck (HP:0100864)1.34562668
109Ectopic kidney (HP:0000086)1.32354236
110J-shaped sella turcica (HP:0002680)1.28616648
111Gaze-evoked nystagmus (HP:0000640)1.27514751
112Chronic hepatic failure (HP:0100626)1.26491580
113Sloping forehead (HP:0000340)1.25433415
114Absent speech (HP:0001344)1.24725612
115Abnormality of renin-angiotensin system (HP:0000847)1.23476693
116Decreased central vision (HP:0007663)1.22531183
117Lip pit (HP:0100267)1.22247424
118Abnormality of chloride homeostasis (HP:0011422)1.18710484
119Sensory axonal neuropathy (HP:0003390)1.18594435
120Abnormality of ocular smooth pursuit (HP:0000617)1.18205790
121Nephroblastoma (Wilms tumor) (HP:0002667)1.17231577
122Chromosomal breakage induced by crosslinking agents (HP:0003221)1.17061839
123Hand muscle atrophy (HP:0009130)1.15140475
124Bifid scrotum (HP:0000048)1.13543471
125Glucose intolerance (HP:0000833)1.12572782
126Abnormality of macular pigmentation (HP:0008002)1.12201267
127Hypokalemic alkalosis (HP:0001949)1.10417668
128Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.09968011
129Abnormal rod and cone electroretinograms (HP:0008323)1.09300453
130Abnormality of the frontal sinuses (HP:0002687)1.09264446
131Carpal bone hypoplasia (HP:0001498)1.09221493
132Abnormality of abdominal situs (HP:0011620)1.08486159
133Abdominal situs inversus (HP:0003363)1.08486159
134Narrow forehead (HP:0000341)1.06956202
135Hip dysplasia (HP:0001385)1.05404051
136Retinitis pigmentosa (HP:0000510)1.04511040
137Hyponatremia (HP:0002902)1.02207656

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK47.80906945
2PDK37.80906945
3MST45.36914246
4PDK25.10162622
5TESK13.70885468
6PRKD33.67137278
7PNCK3.65034600
8ICK2.84753236
9MAP3K22.71249806
10STK392.37416584
11STK242.36560963
12PTK2B2.21376225
13NEK21.97753528
14WNK41.97555691
15FRK1.96056507
16LATS11.87531514
17STK381.86657432
18MAPK151.85072568
19NME11.77681928
20TYRO31.76475617
21MAPKAPK31.74639748
22STK31.54874833
23CDK121.44825420
24TTK1.43009728
25PLK41.42006158
26MAP3K71.37759738
27STK38L1.34962618
28EPHA31.33094490
29LATS21.24936216
30CDC71.17973194
31ACVR1B1.15676405
32MAP3K31.15249321
33CSK1.04901534
34WNK11.03882546
35CHEK20.98211459
36CAMK1G0.93746867
37TRPM70.92137948
38WEE10.88835842
39NTRK20.86264025
40CAMKK20.86215166
41PRKCI0.83954626
42IRAK10.82128549
43INSRR0.79077186
44EEF2K0.74708950
45LRRK20.74282049
46ERBB30.74091630
47MST1R0.74035706
48MET0.71901617
49TLK10.71856294
50PAK60.70475527
51CHEK10.69902239
52LMTK20.66820655
53PDK10.65569301
54DYRK1B0.64096601
55ERBB20.63804843
56MUSK0.62831893
57CASK0.61169357
58SGK10.59414214
59BRSK20.59196345
60ATM0.58624212
61MAP3K130.57522467
62SGK20.55313903
63PLK10.55148229
64RIPK40.54037542
65NEK60.52306500
66GRK10.51893870
67PASK0.51194636
68MAP2K70.50465780
69NEK90.49562830
70MAP3K40.47821472
71SMG10.46794377
72KSR20.45730817
73MARK10.43577053
74PRKCQ0.43544624
75TNIK0.43168511
76DYRK30.42249773
77NLK0.42010862
78FER0.41860938
79SGK4940.40629955
80SGK2230.40629955
81ATR0.40535029
82BRD40.40055594
83MAP2K40.39678516
84PRKAA20.38286980
85PRKCZ0.37480608
86CCNB10.36801725
87PRKAA10.36409011
88PINK10.36263008
89MTOR0.36001950
90BRSK10.35887560
91RET0.35718724
92ADRBK10.34917442
93MARK20.34873323
94CDC42BPA0.33225013
95CAMK2G0.33066158
96FGFR20.32720960
97PRKACA0.32261342
98OXSR10.31833946
99CSNK1D0.31362868
100TBK10.31287413
101IRAK20.30626635
102DYRK1A0.30460217
103MAP3K90.30412678
104YES10.29863829
105HIPK20.28658414
106ROCK10.28095273
107PDGFRB0.27917198
108PAK10.27655321
109PRKCG0.26319848
110ABL10.25928077
111MAPK130.25564827
112ERBB40.25532496
113AKT30.25289766
114CDK10.25279875
115STK100.23830370
116PAK20.23557200
117EPHB10.23537701
118EGFR0.23374544
119NTRK30.23140631
120PDPK10.22418181
121ADRBK20.22299438
122PKN10.22059695
123CDK60.21770696
124EPHA20.21483813
125ARAF0.21218571
126STK110.21184735
127TAOK10.20894343
128PRKCA0.20878279
129MAPK100.20809141
130PRKCD0.20688031
131MAP3K120.19861207
132MAPKAPK50.17832754
133BMPR20.17471457
134GSK3B0.17063329
135DDR20.16939258
136WNK30.16535603
137CSNK1E0.16391999
138BMPR1B0.15816465
139BRAF0.15268011
140CDK20.15206630
141CAMK2A0.14695856
142TIE10.14080734
143PLK20.13744918
144PRKDC0.13091314
145MELK0.12869441
146CAMKK10.12670708
147AURKA0.12369775
148PRKG10.12114817
149EPHA40.11565383
150RPS6KA30.11060443
151PTK20.08953427
152BUB10.08805236
153MAP3K60.07767023
154MAPK80.06803942
155BCR0.06112513
156MARK30.06025886

Predicted pathways (KEGG)

RankGene SetZ-score
1Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009804.74563641
2Vitamin B6 metabolism_Homo sapiens_hsa007504.56856356
3Histidine metabolism_Homo sapiens_hsa003404.01578410
4Chemical carcinogenesis_Homo sapiens_hsa052043.87158409
5Phenylalanine metabolism_Homo sapiens_hsa003603.84113777
6Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.73576265
7Dorso-ventral axis formation_Homo sapiens_hsa043203.55808111
8Fanconi anemia pathway_Homo sapiens_hsa034603.12001371
9Basal transcription factors_Homo sapiens_hsa030222.93001430
10Tyrosine metabolism_Homo sapiens_hsa003502.86800595
11Fatty acid biosynthesis_Homo sapiens_hsa000612.80019248
12alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.64935905
13beta-Alanine metabolism_Homo sapiens_hsa004102.62035186
14Caffeine metabolism_Homo sapiens_hsa002322.57886055
15Oocyte meiosis_Homo sapiens_hsa041142.51408907
16Linoleic acid metabolism_Homo sapiens_hsa005912.49193934
17Pyruvate metabolism_Homo sapiens_hsa006202.44860285
18Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.27367960
19Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.19038674
20Ether lipid metabolism_Homo sapiens_hsa005652.04112466
21Glucagon signaling pathway_Homo sapiens_hsa049222.00322401
22Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.99146321
23Ovarian steroidogenesis_Homo sapiens_hsa049131.93281755
24Retinol metabolism_Homo sapiens_hsa008301.90133204
25Propanoate metabolism_Homo sapiens_hsa006401.79407735
26Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.70749748
27Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.53751241
28Glycerophospholipid metabolism_Homo sapiens_hsa005641.52165430
29Amphetamine addiction_Homo sapiens_hsa050311.46521095
30mRNA surveillance pathway_Homo sapiens_hsa030151.43611169
31Huntingtons disease_Homo sapiens_hsa050161.41404225
32Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.36756140
33Pentose phosphate pathway_Homo sapiens_hsa000301.34860485
34Glycerolipid metabolism_Homo sapiens_hsa005611.32741627
35Selenocompound metabolism_Homo sapiens_hsa004501.31126738
36Steroid hormone biosynthesis_Homo sapiens_hsa001401.30239953
37RNA transport_Homo sapiens_hsa030131.28347716
38Carbohydrate digestion and absorption_Homo sapiens_hsa049731.28007302
39Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.26982359
40Renin secretion_Homo sapiens_hsa049241.24497648
41Phosphatidylinositol signaling system_Homo sapiens_hsa040701.12630157
42Estrogen signaling pathway_Homo sapiens_hsa049151.12155867
43Cyanoamino acid metabolism_Homo sapiens_hsa004601.11377987
44Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.08513734
45Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.07922930
46Taste transduction_Homo sapiens_hsa047421.07481497
47Nicotine addiction_Homo sapiens_hsa050331.02837899
48Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.02553503
49Mineral absorption_Homo sapiens_hsa049781.02311695
50Hedgehog signaling pathway_Homo sapiens_hsa043401.01709182
51Inositol phosphate metabolism_Homo sapiens_hsa005620.99535508
52Cell cycle_Homo sapiens_hsa041100.94393848
53Glutamatergic synapse_Homo sapiens_hsa047240.93446301
54Purine metabolism_Homo sapiens_hsa002300.89749811
55Circadian entrainment_Homo sapiens_hsa047130.86204484
56Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.86075810
57Fatty acid degradation_Homo sapiens_hsa000710.85711375
58Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.85064214
59Salivary secretion_Homo sapiens_hsa049700.80654375
60Long-term potentiation_Homo sapiens_hsa047200.80366380
61cGMP-PKG signaling pathway_Homo sapiens_hsa040220.80000681
62Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.78559590
63Calcium signaling pathway_Homo sapiens_hsa040200.77209126
64Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.76225819
65PPAR signaling pathway_Homo sapiens_hsa033200.75478346
66Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.75352427
67Tight junction_Homo sapiens_hsa045300.73929861
68Serotonergic synapse_Homo sapiens_hsa047260.72979594
69Starch and sucrose metabolism_Homo sapiens_hsa005000.72290569
70Vascular smooth muscle contraction_Homo sapiens_hsa042700.71201368
71Peroxisome_Homo sapiens_hsa041460.69963678
72VEGF signaling pathway_Homo sapiens_hsa043700.69852483
73Wnt signaling pathway_Homo sapiens_hsa043100.68977368
74Adherens junction_Homo sapiens_hsa045200.67949080
75Arachidonic acid metabolism_Homo sapiens_hsa005900.66500069
76cAMP signaling pathway_Homo sapiens_hsa040240.66137506
77Cocaine addiction_Homo sapiens_hsa050300.65149096
78Basal cell carcinoma_Homo sapiens_hsa052170.64368695
79Glycosaminoglycan degradation_Homo sapiens_hsa005310.64235695
80Thyroid hormone synthesis_Homo sapiens_hsa049180.62561776
81Cysteine and methionine metabolism_Homo sapiens_hsa002700.61600569
82Insulin secretion_Homo sapiens_hsa049110.60873567
83Notch signaling pathway_Homo sapiens_hsa043300.60089891
84Synaptic vesicle cycle_Homo sapiens_hsa047210.59921496
85Endocytosis_Homo sapiens_hsa041440.58520508
86Cardiac muscle contraction_Homo sapiens_hsa042600.57846149
87Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.56749030
88Autoimmune thyroid disease_Homo sapiens_hsa053200.56020064
89Oxytocin signaling pathway_Homo sapiens_hsa049210.55623149
90Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.55155607
91Hippo signaling pathway_Homo sapiens_hsa043900.54938974
92AMPK signaling pathway_Homo sapiens_hsa041520.54701939
93Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.54665418
94Type II diabetes mellitus_Homo sapiens_hsa049300.54368793
95Gap junction_Homo sapiens_hsa045400.53670945
96Protein digestion and absorption_Homo sapiens_hsa049740.52930539
97Antigen processing and presentation_Homo sapiens_hsa046120.52893461
98Gastric acid secretion_Homo sapiens_hsa049710.52651189
99Adipocytokine signaling pathway_Homo sapiens_hsa049200.52585135
100Axon guidance_Homo sapiens_hsa043600.51777787
101Morphine addiction_Homo sapiens_hsa050320.51741711
102Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.51717385
103Homologous recombination_Homo sapiens_hsa034400.51562861
104Transcriptional misregulation in cancer_Homo sapiens_hsa052020.51356112
105Drug metabolism - other enzymes_Homo sapiens_hsa009830.51048427
106ECM-receptor interaction_Homo sapiens_hsa045120.50440185
107GnRH signaling pathway_Homo sapiens_hsa049120.50125127
108Circadian rhythm_Homo sapiens_hsa047100.50026217
109Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.49954073
110Leukocyte transendothelial migration_Homo sapiens_hsa046700.48608775
111Sphingolipid metabolism_Homo sapiens_hsa006000.48359815
112RNA degradation_Homo sapiens_hsa030180.48062617
113Olfactory transduction_Homo sapiens_hsa047400.46121061
114ABC transporters_Homo sapiens_hsa020100.45674883
115Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.44280965
116Longevity regulating pathway - mammal_Homo sapiens_hsa042110.44138853
117Regulation of autophagy_Homo sapiens_hsa041400.43565935
118Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.42942182
119Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.41385689
120Collecting duct acid secretion_Homo sapiens_hsa049660.41064420
121Phototransduction_Homo sapiens_hsa047440.41020774
122Aldosterone synthesis and secretion_Homo sapiens_hsa049250.40218309
123Thyroid hormone signaling pathway_Homo sapiens_hsa049190.40096129
124Dopaminergic synapse_Homo sapiens_hsa047280.39982110
125Hepatitis C_Homo sapiens_hsa051600.39905597
126MAPK signaling pathway_Homo sapiens_hsa040100.39505922
127Sphingolipid signaling pathway_Homo sapiens_hsa040710.38044561
128Fatty acid metabolism_Homo sapiens_hsa012120.37475969
129p53 signaling pathway_Homo sapiens_hsa041150.35378488
130Choline metabolism in cancer_Homo sapiens_hsa052310.35344147
131Bile secretion_Homo sapiens_hsa049760.35076682
132Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.34362157
133Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.33939170
134Glutathione metabolism_Homo sapiens_hsa004800.33820818
135Pancreatic secretion_Homo sapiens_hsa049720.32476788
136Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.31689304
137Amoebiasis_Homo sapiens_hsa051460.31684684
138Hematopoietic cell lineage_Homo sapiens_hsa046400.31436437
139Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.31127406
140Pentose and glucuronate interconversions_Homo sapiens_hsa000400.29287409
141Primary bile acid biosynthesis_Homo sapiens_hsa001200.27888964
142Jak-STAT signaling pathway_Homo sapiens_hsa046300.26833294
143Complement and coagulation cascades_Homo sapiens_hsa046100.26541785
144Dilated cardiomyopathy_Homo sapiens_hsa054140.25825277
145GABAergic synapse_Homo sapiens_hsa047270.22209080
146Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.19814436
147mTOR signaling pathway_Homo sapiens_hsa041500.18998531
148Nitrogen metabolism_Homo sapiens_hsa009100.18041545
149Melanogenesis_Homo sapiens_hsa049160.17795329

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