ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	pyrimidine nucleobase catabolic process (GO:0006208)	6.08347147
2	nucleobase catabolic process (GO:0046113)	5.08313386
3	postsynaptic membrane organization (GO:0001941)	4.44593339
4	behavioral response to nicotine (GO:0035095)	4.12264165
5	presynaptic membrane assembly (GO:0097105)	4.02852961
6	neuron cell-cell adhesion (GO:0007158)	3.96806596
7	neuronal action potential propagation (GO:0019227)	3.79542363
8	central nervous system projection neuron axonogenesis (GO:0021952)	3.66176966
9	response to pheromone (GO:0019236)	3.63995874
10	gamma-aminobutyric acid transport (GO:0015812)	3.61447222
11	presynaptic membrane organization (GO:0097090)	3.60535305
12	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	3.58520901
13	vocalization behavior (GO:0071625)	3.57705284
14	ionotropic glutamate receptor signaling pathway (GO:0035235)	3.53655885
15	retinal cone cell development (GO:0046549)	3.47319686
16	synaptic vesicle maturation (GO:0016188)	3.42902359
17	negative regulation of synaptic transmission, GABAergic (GO:0032229)	3.39919628
18	transmission of nerve impulse (GO:0019226)	3.38425981
19	glutamate receptor signaling pathway (GO:0007215)	3.37625311
20	positive regulation of action potential (GO:0045760)	3.36299863
21	protein polyglutamylation (GO:0018095)	3.34018575
22	central nervous system neuron axonogenesis (GO:0021955)	3.32848423
23	startle response (GO:0001964)	3.31985271
24	protein localization to synapse (GO:0035418)	3.28200751
25	regulation of action potential (GO:0098900)	3.27303931
26	proline transport (GO:0015824)	3.26647689
27	platelet dense granule organization (GO:0060155)	3.24168511
28	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	3.22812655
29	synaptic transmission, glutamatergic (GO:0035249)	3.22457068
30	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	3.22375444
31	sympathetic nervous system development (GO:0048485)	3.21935390
32	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.19619026
33	neuron recognition (GO:0008038)	3.18882126
34	negative regulation of synaptic transmission, glutamatergic (GO:0051967)	3.05702979
35	neural tube formation (GO:0001841)	3.05405740
36	dendritic spine morphogenesis (GO:0060997)	3.05349732
37	limb bud formation (GO:0060174)	3.04397893
38	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.04294563
39	C4-dicarboxylate transport (GO:0015740)	3.03223055
40	axonal fasciculation (GO:0007413)	3.00337367
41	tachykinin receptor signaling pathway (GO:0007217)	2.99246667
42	cerebral cortex radially oriented cell migration (GO:0021799)	2.99205651
43	establishment of mitochondrion localization (GO:0051654)	2.98000815
44	serotonin metabolic process (GO:0042428)	2.97698697
45	head development (GO:0060322)	2.97531921
46	retinal ganglion cell axon guidance (GO:0031290)	2.96439674
47	adaptation of signaling pathway (GO:0023058)	2.93810664
48	axoneme assembly (GO:0035082)	2.92522938
49	detection of light stimulus involved in visual perception (GO:0050908)	2.92508982
50	detection of light stimulus involved in sensory perception (GO:0050962)	2.92508982
51	regulation of short-term neuronal synaptic plasticity (GO:0048172)	2.91231891
52	positive regulation of excitatory postsynaptic membrane potential (GO:2000463)	2.90077062
53	regulation of neurotransmitter uptake (GO:0051580)	2.89746265
54	primary amino compound metabolic process (GO:1901160)	2.89558424
55	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.88379921
56	neuromuscular synaptic transmission (GO:0007274)	2.87955086
57	neuron-neuron synaptic transmission (GO:0007270)	2.87431379
58	cell migration in hindbrain (GO:0021535)	2.84415581
59	behavioral response to ethanol (GO:0048149)	2.83777762
60	nonmotile primary cilium assembly (GO:0035058)	2.79551567
61	fucose catabolic process (GO:0019317)	2.78142337
62	L-fucose metabolic process (GO:0042354)	2.78142337
63	L-fucose catabolic process (GO:0042355)	2.78142337
64	membrane depolarization during action potential (GO:0086010)	2.77404161
65	synapse assembly (GO:0007416)	2.76404320
66	neurotransmitter-gated ion channel clustering (GO:0072578)	2.75256876
67	neurotransmitter secretion (GO:0007269)	2.74406058
68	glycosphingolipid biosynthetic process (GO:0006688)	2.71696617
69	inner ear receptor stereocilium organization (GO:0060122)	2.71432745
70	cAMP catabolic process (GO:0006198)	2.70147827
71	neuronal action potential (GO:0019228)	2.69051808
72	cyclic nucleotide catabolic process (GO:0009214)	2.68125108
73	adult walking behavior (GO:0007628)	2.67324060
74	somite development (GO:0061053)	2.66041789
75	auditory behavior (GO:0031223)	2.65690197
76	synaptic transmission, cholinergic (GO:0007271)	2.63038265
77	protein localization to cilium (GO:0061512)	2.60296390
78	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)	2.59089279
79	glutamate secretion (GO:0014047)	2.58730099
80	dendrite morphogenesis (GO:0048813)	2.57795927
81	cilium morphogenesis (GO:0060271)	2.57390418
82	positive regulation of synaptic transmission, GABAergic (GO:0032230)	2.56729840
83	indolalkylamine metabolic process (GO:0006586)	2.56322480
84	anterograde axon cargo transport (GO:0008089)	2.54801212
85	epithelial cilium movement (GO:0003351)	2.53865729
86	regulation of collateral sprouting (GO:0048670)	2.53741674
87	positive regulation of synapse assembly (GO:0051965)	2.52495275
88	cornea development in camera-type eye (GO:0061303)	2.52253422
89	regulation of respiratory system process (GO:0044065)	2.51770672
90	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.51551284
91	detection of mechanical stimulus involved in sensory perception (GO:0050974)	2.51381725
92	regulation of synaptic transmission, GABAergic (GO:0032228)	2.51026646
93	synaptic vesicle exocytosis (GO:0016079)	2.49571336
94	alanine transport (GO:0032328)	2.49212845
95	reflex (GO:0060004)	2.49054388
96	anterograde synaptic vesicle transport (GO:0048490)	2.46339141
97	spinal cord development (GO:0021510)	2.45517883
98	behavioral response to cocaine (GO:0048148)	2.44907937
99	regulation of synaptic transmission, glutamatergic (GO:0051966)	2.44755602
100	negative regulation of heart rate (GO:0010459)	2.44653835

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	4.32494100
2	GBX2_23144817_ChIP-Seq_PC3_Human	3.89372809
3	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.35431650
4	ZNF274_21170338_ChIP-Seq_K562_Hela	3.11287852
5	IGF1R_20145208_ChIP-Seq_DFB_Human	2.76308899
6	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.71967370
7	TAF15_26573619_Chip-Seq_HEK293_Human	2.49431985
8	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.35451537
9	VDR_22108803_ChIP-Seq_LS180_Human	2.30996049
10	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.27647866
11	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.27234593
12	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.22253064
13	P300_19829295_ChIP-Seq_ESCs_Human	2.11551902
14	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.09140903
15	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.08509813
16	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.06590615
17	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.98274215
18	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.91564566
19	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.91191098
20	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.87085315
21	REST_21632747_ChIP-Seq_MESCs_Mouse	1.86411881
22	FUS_26573619_Chip-Seq_HEK293_Human	1.85213326
23	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.83479609
24	SMAD4_21799915_ChIP-Seq_A2780_Human	1.79296793
25	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.72943739
26	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.72928509
27	EWS_26573619_Chip-Seq_HEK293_Human	1.68932277
28	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.63644100
29	ER_23166858_ChIP-Seq_MCF-7_Human	1.61654604
30	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.60404118
31	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.60404118
32	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.59492617
33	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.59428185
34	STAT3_23295773_ChIP-Seq_U87_Human	1.58815418
35	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.58623517
36	DROSHA_22980978_ChIP-Seq_HELA_Human	1.57835692
37	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.57802047
38	AR_21572438_ChIP-Seq_LNCaP_Human	1.56952435
39	BCAT_22108803_ChIP-Seq_LS180_Human	1.55744815
40	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.54597891
41	AR_25329375_ChIP-Seq_VCAP_Human	1.54421242
42	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.53858613
43	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.52710881
44	CBP_20019798_ChIP-Seq_JUKART_Human	1.50498072
45	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.50498072
46	TCF4_23295773_ChIP-Seq_U87_Human	1.49498069
47	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.48617137
48	RNF2_27304074_Chip-Seq_NSC_Mouse	1.48346518
49	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.47525170
50	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.46180790
51	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.44305990
52	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.42211134
53	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.41087151
54	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.36617195
55	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.36478813
56	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.33467332
57	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.30140137
58	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.29260427
59	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.27938471
60	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.27686133
61	RUNX2_22187159_ChIP-Seq_PCA_Human	1.26629723
62	TCF4_22108803_ChIP-Seq_LS180_Human	1.23219897
63	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.20580350
64	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.19740280
65	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.19178553
66	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.18628315
67	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.18134570
68	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.17340646
69	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.16786826
70	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.16675950
71	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.16556366
72	TP53_22573176_ChIP-Seq_HFKS_Human	1.16288850
73	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.16077689
74	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.16039076
75	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.15320801
76	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.14509876
77	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.14289560
78	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.14133515
79	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.13205456
80	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.12732119
81	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.12254491
82	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.12214369
83	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.11027540
84	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.06833807
85	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.06260886
86	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.06226569
87	SOX2_19829295_ChIP-Seq_ESCs_Human	1.05420313
88	NANOG_19829295_ChIP-Seq_ESCs_Human	1.05420313
89	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.04834006
90	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.04223208
91	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.03920160
92	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.03920160
93	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.03599454
94	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.01940058
95	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.01231715
96	KDM2B_26808549_Chip-Seq_REH_Human	1.00876350
97	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.00562002
98	P53_22387025_ChIP-Seq_ESCs_Mouse	1.00352290
99	TP53_16413492_ChIP-PET_HCT116_Human	1.00064242
100	JUN_21703547_ChIP-Seq_K562_Human	0.99238913

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003880_abnormal_central_pattern	3.44070872
2	MP0004859_abnormal_synaptic_plasticity	3.21248245
3	MP0003787_abnormal_imprinting	3.01887196
4	MP0001968_abnormal_touch/_nociception	2.89142462
5	MP0002736_abnormal_nociception_after	2.75109143
6	MP0009745_abnormal_behavioral_response	2.56884566
7	MP0003635_abnormal_synaptic_transmissio	2.48708469
8	MP0000778_abnormal_nervous_system	2.28117006
9	MP0001486_abnormal_startle_reflex	2.28034455
10	MP0006276_abnormal_autonomic_nervous	2.26960677
11	MP0008877_abnormal_DNA_methylation	2.24882621
12	MP0002735_abnormal_chemical_nociception	2.23554994
13	MP0009046_muscle_twitch	2.20047804
14	MP0001501_abnormal_sleep_pattern	2.18541440
15	MP0001529_abnormal_vocalization	2.17659973
16	MP0002102_abnormal_ear_morphology	2.16633775
17	MP0002272_abnormal_nervous_system	2.15953331
18	MP0004270_analgesia	2.15692006
19	MP0002063_abnormal_learning/memory/cond	2.14155101
20	MP0002572_abnormal_emotion/affect_behav	2.13252081
21	MP0002064_seizures	2.04340908
22	MP0005551_abnormal_eye_electrophysiolog	2.00921234
23	MP0001984_abnormal_olfaction	1.92513312
24	MP0002734_abnormal_mechanical_nocicepti	1.83614985
25	MP0002638_abnormal_pupillary_reflex	1.82500177
26	MP0000569_abnormal_digit_pigmentation	1.81571767
27	MP0005423_abnormal_somatic_nervous	1.77694793
28	MP0003122_maternal_imprinting	1.75024406
29	MP0005646_abnormal_pituitary_gland	1.73843028
30	MP0002822_catalepsy	1.71364295
31	MP0002557_abnormal_social/conspecific_i	1.70485972
32	MP0003136_yellow_coat_color	1.68295202
33	MP0004147_increased_porphyrin_level	1.66495640
34	MP0001970_abnormal_pain_threshold	1.65560912
35	MP0004142_abnormal_muscle_tone	1.64544303
36	MP0002653_abnormal_ependyma_morphology	1.62545493
37	MP0004885_abnormal_endolymph	1.62053050
38	MP0002067_abnormal_sensory_capabilities	1.61675644
39	MP0004924_abnormal_behavior	1.55777259
40	MP0005386_behavior/neurological_phenoty	1.55777259
41	MP0003121_genomic_imprinting	1.55530988
42	MP0005253_abnormal_eye_physiology	1.55086591
43	MP0002184_abnormal_innervation	1.54239146
44	MP0008872_abnormal_physiological_respon	1.49031919
45	MP0002733_abnormal_thermal_nociception	1.44772072
46	MP0002751_abnormal_autonomic_nervous	1.40457171
47	MP0001986_abnormal_taste_sensitivity	1.40120393
48	MP0010386_abnormal_urinary_bladder	1.39882568
49	MP0005645_abnormal_hypothalamus_physiol	1.39338895
50	MP0003195_calcinosis	1.34974007
51	MP0006072_abnormal_retinal_apoptosis	1.33773757
52	MP0002882_abnormal_neuron_morphology	1.31440958
53	MP0003011_delayed_dark_adaptation	1.29587896
54	MP0009780_abnormal_chondrocyte_physiolo	1.26836462
55	MP0000955_abnormal_spinal_cord	1.26814971
56	MP0004742_abnormal_vestibular_system	1.25896459
57	MP0005499_abnormal_olfactory_system	1.22123187
58	MP0005394_taste/olfaction_phenotype	1.22123187
59	MP0000631_abnormal_neuroendocrine_gland	1.21262733
60	MP0008789_abnormal_olfactory_epithelium	1.19198465
61	MP0001905_abnormal_dopamine_level	1.18914179
62	MP0001502_abnormal_circadian_rhythm	1.18745201
63	MP0004811_abnormal_neuron_physiology	1.18625122
64	MP0002752_abnormal_somatic_nervous	1.17379102
65	MP0004133_heterotaxia	1.16350381
66	MP0002234_abnormal_pharynx_morphology	1.13064186
67	MP0002837_dystrophic_cardiac_calcinosis	1.08524236
68	MP0005187_abnormal_penis_morphology	1.06536467
69	MP0000427_abnormal_hair_cycle	1.06433748
70	MP0001485_abnormal_pinna_reflex	1.05667767
71	MP0000026_abnormal_inner_ear	1.01417994
72	MP0002066_abnormal_motor_capabilities/c	1.00907885
73	MP0002909_abnormal_adrenal_gland	0.96877131
74	MP0002152_abnormal_brain_morphology	0.95221521
75	MP0004043_abnormal_pH_regulation	0.95071787
76	MP0001963_abnormal_hearing_physiology	0.92982297
77	MP0002229_neurodegeneration	0.92201087
78	MP0005174_abnormal_tail_pigmentation	0.91959021
79	MP0001440_abnormal_grooming_behavior	0.91685393
80	MP0005195_abnormal_posterior_eye	0.91642934
81	MP0002876_abnormal_thyroid_physiology	0.89756085
82	MP0006292_abnormal_olfactory_placode	0.89142356
83	MP0000049_abnormal_middle_ear	0.88707018
84	MP0003119_abnormal_digestive_system	0.85935197
85	MP0005367_renal/urinary_system_phenotyp	0.85889619
86	MP0000516_abnormal_urinary_system	0.85889619
87	MP0003633_abnormal_nervous_system	0.84779293
88	MP0002928_abnormal_bile_duct	0.84570781
89	MP0002069_abnormal_eating/drinking_beha	0.84564025
90	MP0003698_abnormal_male_reproductive	0.83042810
91	MP0001188_hyperpigmentation	0.82724599
92	MP0003938_abnormal_ear_development	0.82579655
93	MP0008569_lethality_at_weaning	0.78720875
94	MP0001177_atelectasis	0.75967711
95	MP0008875_abnormal_xenobiotic_pharmacok	0.75301191
96	MP0000372_irregular_coat_pigmentation	0.75041118
97	MP0003861_abnormal_nervous_system	0.74793219
98	MP0005410_abnormal_fertilization	0.74751202
99	MP0004145_abnormal_muscle_electrophysio	0.74362005
100	MP0003631_nervous_system_phenotype	0.72371555

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hyperventilation (HP:0002883)	4.28582631
2	Focal motor seizures (HP:0011153)	4.11446888
3	Focal seizures (HP:0007359)	3.99354377
4	Type II lissencephaly (HP:0007260)	3.79363162
5	Febrile seizures (HP:0002373)	3.72648134
6	Pancreatic cysts (HP:0001737)	3.69123906
7	Abnormality of midbrain morphology (HP:0002418)	3.62468715
8	Molar tooth sign on MRI (HP:0002419)	3.62468715
9	True hermaphroditism (HP:0010459)	3.47934413
10	Pancreatic fibrosis (HP:0100732)	3.34256090
11	Lissencephaly (HP:0001339)	3.30040138
12	Congenital stationary night blindness (HP:0007642)	3.28303823
13	Nephronophthisis (HP:0000090)	3.24166060
14	Atonic seizures (HP:0010819)	3.13296371
15	Absent speech (HP:0001344)	3.12073348
16	Progressive cerebellar ataxia (HP:0002073)	3.08604475
17	Retinal dysplasia (HP:0007973)	2.97882419
18	Gait imbalance (HP:0002141)	2.95753508
19	Medial flaring of the eyebrow (HP:0010747)	2.89720271
20	Drooling (HP:0002307)	2.81538031
21	Abnormality of the renal medulla (HP:0100957)	2.80276795
22	Genetic anticipation (HP:0003743)	2.77572806
23	Gaze-evoked nystagmus (HP:0000640)	2.76345606
24	Pachygyria (HP:0001302)	2.67393953
25	Chronic hepatic failure (HP:0100626)	2.66949313
26	Limb dystonia (HP:0002451)	2.63647769
27	Abnormality of the labia minora (HP:0012880)	2.63579478
28	Dialeptic seizures (HP:0011146)	2.57067622
29	Broad-based gait (HP:0002136)	2.53401295
30	Excessive salivation (HP:0003781)	2.52931337
31	Congenital primary aphakia (HP:0007707)	2.52904057
32	Abnormality of the renal cortex (HP:0011035)	2.50869394
33	Nephrogenic diabetes insipidus (HP:0009806)	2.47042070
34	Keratoconus (HP:0000563)	2.46725794
35	Increased corneal curvature (HP:0100692)	2.46725794
36	Genital tract atresia (HP:0001827)	2.45363212
37	Cystic liver disease (HP:0006706)	2.43585903
38	Cerebellar dysplasia (HP:0007033)	2.43123464
39	Widely spaced teeth (HP:0000687)	2.41290299
40	Polyphagia (HP:0002591)	2.36216726
41	Attenuation of retinal blood vessels (HP:0007843)	2.36156202
42	Volvulus (HP:0002580)	2.35784764
43	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.35093537
44	Vaginal atresia (HP:0000148)	2.35011502
45	Hemiparesis (HP:0001269)	2.33977268
46	Protruding tongue (HP:0010808)	2.31787641
47	Intestinal atresia (HP:0011100)	2.27547111
48	Epileptic encephalopathy (HP:0200134)	2.21394545
49	Pendular nystagmus (HP:0012043)	2.18682627
50	Renal cortical cysts (HP:0000803)	2.14277564
51	Tubulointerstitial nephritis (HP:0001970)	2.13997531
52	Oligodactyly (hands) (HP:0001180)	2.07954924
53	Optic nerve hypoplasia (HP:0000609)	2.07067834
54	Hypsarrhythmia (HP:0002521)	2.07042739
55	Decreased central vision (HP:0007663)	2.06858022
56	Absence seizures (HP:0002121)	2.06177081
57	Epileptiform EEG discharges (HP:0011182)	2.05756676
58	EEG with generalized epileptiform discharges (HP:0011198)	2.03531431
59	Tented upper lip vermilion (HP:0010804)	2.02678854
60	Generalized tonic-clonic seizures (HP:0002069)	2.00316163
61	Short tibia (HP:0005736)	1.98484887
62	Myokymia (HP:0002411)	1.96723887
63	Poor coordination (HP:0002370)	1.96691662
64	Bifid tongue (HP:0010297)	1.95955766
65	Postaxial hand polydactyly (HP:0001162)	1.95303989
66	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	1.94895885
67	Inability to walk (HP:0002540)	1.94828643
68	Specific learning disability (HP:0001328)	1.94173650
69	Narrow forehead (HP:0000341)	1.93959330
70	Sclerocornea (HP:0000647)	1.93046455
71	Anencephaly (HP:0002323)	1.89233349
72	Abnormality of macular pigmentation (HP:0008002)	1.88641156
73	Aplasia/Hypoplasia of the brainstem (HP:0007362)	1.88161496
74	Hypoplasia of the brainstem (HP:0002365)	1.88161496
75	Severe muscular hypotonia (HP:0006829)	1.87908707
76	Chorioretinal atrophy (HP:0000533)	1.87445073
77	Absent/shortened dynein arms (HP:0200106)	1.87018732
78	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.87018732
79	Renal hypoplasia (HP:0000089)	1.84179597
80	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.83542294
81	Progressive inability to walk (HP:0002505)	1.82574560
82	Polymicrogyria (HP:0002126)	1.82351429
83	Hypoplastic ischia (HP:0003175)	1.81818954
84	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.81453312
85	Short foot (HP:0001773)	1.81418193
86	Exotropia (HP:0000577)	1.80463543
87	Urinary bladder sphincter dysfunction (HP:0002839)	1.80407615
88	Stomach cancer (HP:0012126)	1.78937405
89	Dyskinesia (HP:0100660)	1.75652889
90	Abnormality of the pubic bones (HP:0003172)	1.75647519
91	Aplasia/Hypoplasia of the patella (HP:0006498)	1.74519035
92	Methylmalonic acidemia (HP:0002912)	1.73455684
93	Patellar aplasia (HP:0006443)	1.72682425
94	Esotropia (HP:0000565)	1.72223370
95	Male pseudohermaphroditism (HP:0000037)	1.71816162
96	Adactyly (HP:0009776)	1.71691187
97	Abnormality of the ischium (HP:0003174)	1.71687604
98	Small hand (HP:0200055)	1.71448033
99	Agitation (HP:0000713)	1.71257725
100	Highly arched eyebrow (HP:0002553)	1.69757062

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MARK1	4.72052604
2	FRK	3.86874093
3	CASK	3.55767782
4	WNK3	3.54958913
5	MAPK13	2.95480624
6	MAP3K4	2.64092097
7	EPHA4	2.56484564
8	BMPR1B	2.38946736
9	ADRBK2	2.33700788
10	NTRK3	2.31558905
11	ACVR1B	2.19996947
12	MAP4K2	2.17090361
13	BCR	2.00736528
14	PINK1	1.94216934
15	TRIM28	1.89432023
16	NUAK1	1.69470803
17	PAK3	1.68123662
18	DYRK2	1.63975212
19	NTRK2	1.62195080
20	MAP2K7	1.60792157
21	TNIK	1.51670607
22	TAOK3	1.49624473
23	PLK2	1.49166438
24	PRKD3	1.48807194
25	GRK1	1.44911058
26	DAPK2	1.44106103
27	PAK6	1.35437304
28	CSNK1G2	1.34583185
29	SIK2	1.27229006
30	ERBB3	1.21870254
31	PRKCG	1.16639925
32	MINK1	1.15392094
33	PRKCE	1.12191978
34	CSNK1A1L	1.05702055
35	CSNK1G3	1.02233435
36	OXSR1	0.99373488
37	CSNK1G1	0.94832758
38	PHKG1	0.93091953
39	PHKG2	0.93091953
40	PNCK	0.91843710
41	ZAK	0.90443829
42	DYRK1A	0.86715999
43	MAP2K4	0.85661716
44	EPHB2	0.85316343
45	STK38L	0.84467184
46	PKN1	0.83679879
47	SIK3	0.80754197
48	ADRBK1	0.80090355
49	EPHA3	0.79844768
50	CAMK2A	0.79502567
51	CDK5	0.77822033
52	WNK4	0.76914076
53	INSRR	0.75793168
54	PRKCZ	0.74562579
55	STK39	0.73465935
56	KSR1	0.71928660
57	MAPK15	0.65820967
58	STK11	0.65692117
59	CAMKK2	0.65018273
60	MKNK2	0.63583621
61	SGK2	0.61884177
62	CSNK1D	0.61666712
63	SGK494	0.56689175
64	SGK223	0.56689175
65	LATS1	0.56485869
66	CAMK1	0.55941095
67	TXK	0.55317477
68	LIMK1	0.50651030
69	FER	0.46267917
70	NTRK1	0.45850944
71	PTK2B	0.44302251
72	PRKACA	0.43682485
73	CSNK1A1	0.43055860
74	MARK3	0.42601029
75	CAMK2B	0.42221685
76	ERBB2	0.40001117
77	AKT3	0.38688571
78	MAP2K1	0.38683545
79	CAMK1G	0.37653711
80	GRK5	0.37565625
81	PRKG1	0.37223147
82	TGFBR1	0.36971280
83	FGFR2	0.36943994
84	PRKCI	0.36893047
85	IRAK1	0.36085025
86	PRKAA1	0.35996527
87	PRKCH	0.33879709
88	CAMK4	0.33677258
89	UHMK1	0.32919205
90	BRD4	0.32162858
91	BCKDK	0.32062995
92	PIK3CA	0.31910353
93	CDK19	0.30306691
94	CDK3	0.29847076
95	PRKACB	0.28586519
96	TLK1	0.28436529
97	RPS6KA3	0.27867851
98	STK38	0.27603677
99	SGK1	0.27448302
100	PLK4	0.27051327

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nicotine addiction_Homo sapiens_hsa05033	4.11920422
2	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	3.01280339
3	Phototransduction_Homo sapiens_hsa04744	2.88892020
4	Morphine addiction_Homo sapiens_hsa05032	2.30983738
5	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.22066152
6	Taste transduction_Homo sapiens_hsa04742	2.20607041
7	Circadian entrainment_Homo sapiens_hsa04713	2.19727204
8	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	2.19240428
9	Glutamatergic synapse_Homo sapiens_hsa04724	2.19214744
10	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.17693656
11	GABAergic synapse_Homo sapiens_hsa04727	2.17516489
12	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.08013679
13	Synaptic vesicle cycle_Homo sapiens_hsa04721	2.03160566
14	Butanoate metabolism_Homo sapiens_hsa00650	1.96779669
15	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.86000339
16	Dopaminergic synapse_Homo sapiens_hsa04728	1.82249935
17	Olfactory transduction_Homo sapiens_hsa04740	1.76978359
18	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.76558320
19	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.72119996
20	Insulin secretion_Homo sapiens_hsa04911	1.70352152
21	Cocaine addiction_Homo sapiens_hsa05030	1.66124258
22	Amphetamine addiction_Homo sapiens_hsa05031	1.65840495
23	Linoleic acid metabolism_Homo sapiens_hsa00591	1.57514953
24	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.52184504
25	Selenocompound metabolism_Homo sapiens_hsa00450	1.47371325
26	Nitrogen metabolism_Homo sapiens_hsa00910	1.45727299
27	Serotonergic synapse_Homo sapiens_hsa04726	1.37436519
28	Ether lipid metabolism_Homo sapiens_hsa00565	1.37361008
29	Collecting duct acid secretion_Homo sapiens_hsa04966	1.35408764
30	Cholinergic synapse_Homo sapiens_hsa04725	1.34759482
31	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.33083011
32	Axon guidance_Homo sapiens_hsa04360	1.25155805
33	Protein export_Homo sapiens_hsa03060	1.24605451
34	Calcium signaling pathway_Homo sapiens_hsa04020	1.20586805
35	Fanconi anemia pathway_Homo sapiens_hsa03460	1.18351367
36	cAMP signaling pathway_Homo sapiens_hsa04024	1.17605426
37	Salivary secretion_Homo sapiens_hsa04970	1.17090915
38	ABC transporters_Homo sapiens_hsa02010	1.14016027
39	Propanoate metabolism_Homo sapiens_hsa00640	1.13185120
40	Long-term depression_Homo sapiens_hsa04730	1.05401929
41	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.04625789
42	Basal transcription factors_Homo sapiens_hsa03022	0.99605809
43	Circadian rhythm_Homo sapiens_hsa04710	0.98933528
44	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.97132024
45	Tryptophan metabolism_Homo sapiens_hsa00380	0.95083652
46	beta-Alanine metabolism_Homo sapiens_hsa00410	0.94052730
47	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.93858334
48	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.92843517
49	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.85815494
50	Gastric acid secretion_Homo sapiens_hsa04971	0.84526199
51	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.83938761
52	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.81892498
53	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.81168295
54	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.80381792
55	Regulation of autophagy_Homo sapiens_hsa04140	0.79180173
56	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.77727373
57	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.77681325
58	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.76200674
59	Renin secretion_Homo sapiens_hsa04924	0.76035713
60	Glycerolipid metabolism_Homo sapiens_hsa00561	0.75655819
61	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.74990209
62	Caffeine metabolism_Homo sapiens_hsa00232	0.73347943
63	Peroxisome_Homo sapiens_hsa04146	0.69659849
64	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.67019466
65	Hippo signaling pathway_Homo sapiens_hsa04390	0.64069475
66	Cardiac muscle contraction_Homo sapiens_hsa04260	0.63680020
67	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.63476472
68	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.62859165
69	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.62392203
70	Fatty acid metabolism_Homo sapiens_hsa01212	0.60323567
71	Oxidative phosphorylation_Homo sapiens_hsa00190	0.58374315
72	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.57133129
73	Non-homologous end-joining_Homo sapiens_hsa03450	0.56872161
74	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.53657085
75	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.49225132
76	Basal cell carcinoma_Homo sapiens_hsa05217	0.49039607
77	Long-term potentiation_Homo sapiens_hsa04720	0.48393282
78	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.46523217
79	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.45885524
80	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.43890768
81	RNA degradation_Homo sapiens_hsa03018	0.43294495
82	Chemical carcinogenesis_Homo sapiens_hsa05204	0.41494594
83	Wnt signaling pathway_Homo sapiens_hsa04310	0.40784397
84	Steroid biosynthesis_Homo sapiens_hsa00100	0.40704779
85	Type II diabetes mellitus_Homo sapiens_hsa04930	0.40268586
86	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.40081489
87	Ras signaling pathway_Homo sapiens_hsa04014	0.38943265
88	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.37351759
89	Gap junction_Homo sapiens_hsa04540	0.37328926
90	Melanogenesis_Homo sapiens_hsa04916	0.36991745
91	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.36966162
92	Oocyte meiosis_Homo sapiens_hsa04114	0.35719702
93	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.34883917
94	Parkinsons disease_Homo sapiens_hsa05012	0.34783525
95	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.33953985
96	Retinol metabolism_Homo sapiens_hsa00830	0.31872310
97	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.31586106
98	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.30535098
99	Pancreatic secretion_Homo sapiens_hsa04972	0.30453418
100	MAPK signaling pathway_Homo sapiens_hsa04010	0.29959635

DNAH10OS

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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