DNAH11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a ciliary outer dynein arm protein and is a member of the dynein heavy chain family. It is a microtubule-dependent motor ATPase and has been reported to be involved in the movement of respiratory cilia. Mutations in this gene have been implicated in causing Kartagener Syndrome (a combination of situs inversus totalis and Primary Ciliary Dyskinesia (PCD), also called Immotile Cilia Syndrome 1 (ICS1)) and male sterility. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)9.20946291
2epithelial cilium movement (GO:0003351)8.35656213
3axoneme assembly (GO:0035082)8.27136470
4left/right pattern formation (GO:0060972)6.98375126
5epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.47681923
6left/right axis specification (GO:0070986)6.21552575
7ventricular system development (GO:0021591)6.02030535
8GTP biosynthetic process (GO:0006183)5.92731655
9intraciliary transport (GO:0042073)5.59222099
10UTP biosynthetic process (GO:0006228)5.28902219
11motile cilium assembly (GO:0044458)5.26042505
12intra-S DNA damage checkpoint (GO:0031573)5.22618554
13nucleoside diphosphate phosphorylation (GO:0006165)5.16768156
14multicellular organismal aging (GO:0010259)4.93488571
15retinal cone cell development (GO:0046549)4.82909292
16meiotic cell cycle (GO:0051321)4.80972908
17protein localization to cilium (GO:0061512)4.79144672
18UTP metabolic process (GO:0046051)4.76877476
19cilium organization (GO:0044782)4.66346607
20cilium assembly (GO:0042384)4.40104327
21piRNA metabolic process (GO:0034587)4.39184531
22male meiosis I (GO:0007141)4.36345992
23male meiosis (GO:0007140)4.20344178
24vitamin transmembrane transport (GO:0035461)4.14586631
25regulation of microtubule-based movement (GO:0060632)4.09951195
26primary alcohol catabolic process (GO:0034310)4.05776481
27centriole assembly (GO:0098534)4.00752749
28microtubule bundle formation (GO:0001578)3.96396347
29photoreceptor cell maintenance (GO:0045494)3.94643173
30negative regulation of hormone biosynthetic process (GO:0032353)3.91223174
31negative regulation of hormone metabolic process (GO:0032351)3.91223174
32meiosis I (GO:0007127)3.86901222
33spermatid nucleus differentiation (GO:0007289)3.86167216
34CTP biosynthetic process (GO:0006241)3.84486651
35CTP metabolic process (GO:0046036)3.84486651
36regulation of interleukin-5 production (GO:0032674)3.84229975
37otic vesicle formation (GO:0030916)3.83571374
38retinal rod cell development (GO:0046548)3.80941823
39cilium morphogenesis (GO:0060271)3.71885118
40DNA replication checkpoint (GO:0000076)3.70990923
41interkinetic nuclear migration (GO:0022027)3.69977566
42chromatin remodeling at centromere (GO:0031055)3.64935567
43guanosine-containing compound biosynthetic process (GO:1901070)3.64227128
44one-carbon compound transport (GO:0019755)3.60089128
45pyrimidine-containing compound transmembrane transport (GO:0072531)3.59622622
46microtubule polymerization or depolymerization (GO:0031109)3.58238010
47protein polyglutamylation (GO:0018095)3.55183338
48cellular component assembly involved in morphogenesis (GO:0010927)3.52912239
49pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.51561398
50diterpenoid biosynthetic process (GO:0016102)3.49681662
51microtubule severing (GO:0051013)3.49103981
52cytoplasmic microtubule organization (GO:0031122)3.48468973
53regulation of cilium movement (GO:0003352)3.47985246
54pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.47314700
55pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.45520051
56ethanol metabolic process (GO:0006067)3.43907555
57centriole replication (GO:0007099)3.40855430
58glomerular epithelial cell development (GO:0072310)3.40777897
59negative regulation of circadian rhythm (GO:0042754)3.37627321
60negative regulation of humoral immune response (GO:0002921)3.37381023
61response to xenobiotic stimulus (GO:0009410)3.36012924
62regulation of centriole replication (GO:0046599)3.32526067
63* microtubule-based movement (GO:0007018)3.31525272
64nucleus localization (GO:0051647)3.31040654
65peptidyl-lysine dimethylation (GO:0018027)3.30625671
66female gamete generation (GO:0007292)3.26813242
67pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)3.23626642
68mitotic metaphase plate congression (GO:0007080)3.22653661
69suckling behavior (GO:0001967)3.19983107
70microtubule depolymerization (GO:0007019)3.19574461
71smoothened signaling pathway (GO:0007224)3.17058353
72cell projection assembly (GO:0030031)3.11574252
73response to pheromone (GO:0019236)3.01831595
74regulation of meiosis (GO:0040020)3.01768346
75* determination of left/right symmetry (GO:0007368)3.01595978
76synaptonemal complex organization (GO:0070193)3.00647578
77nonmotile primary cilium assembly (GO:0035058)2.98743799
78CENP-A containing nucleosome assembly (GO:0034080)2.98125758
79metaphase plate congression (GO:0051310)2.97575856
80organelle assembly (GO:0070925)2.94303273
81histone exchange (GO:0043486)2.94032648
82regulation of interleukin-13 production (GO:0032656)2.93121423
83synaptonemal complex assembly (GO:0007130)2.91747682
84* determination of bilateral symmetry (GO:0009855)2.90817813
85DNA methylation involved in gamete generation (GO:0043046)2.90776303
86nucleotide phosphorylation (GO:0046939)2.90742213
87regulation of centrosome cycle (GO:0046605)2.90458600
88DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.89608205
89regulation of cell cycle G2/M phase transition (GO:1902749)2.88454429
90* microtubule-based process (GO:0007017)2.87513327
91meiotic nuclear division (GO:0007126)2.86354423
92regulation of sister chromatid cohesion (GO:0007063)2.84768615
93DNA damage response, signal transduction resulting in transcription (GO:0042772)2.84554501
94* specification of symmetry (GO:0009799)2.83424918
95negative regulation of B cell mediated immunity (GO:0002713)2.83339017
96negative regulation of immunoglobulin mediated immune response (GO:0002890)2.83339017
97sperm motility (GO:0030317)2.82663843
98neural tube formation (GO:0001841)2.81388160
99paraxial mesoderm development (GO:0048339)2.81379795
100regulation of female gonad development (GO:2000194)2.79684031
101negative regulation of inclusion body assembly (GO:0090084)2.78764722
102sperm capacitation (GO:0048240)2.77959424
103negative regulation of T cell differentiation in thymus (GO:0033085)2.75966135
104nuclear pore complex assembly (GO:0051292)2.74768726
105establishment of chromosome localization (GO:0051303)2.74358341
106lung epithelium development (GO:0060428)2.73367166
107negative regulation of glucose import (GO:0046325)2.72397062
108positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.71424779
109meiotic chromosome segregation (GO:0045132)2.70929775
110DNA replication-independent nucleosome organization (GO:0034724)2.68849434
111DNA replication-independent nucleosome assembly (GO:0006336)2.68849434
112acrosome assembly (GO:0001675)2.68648752
113meiotic cell cycle process (GO:1903046)2.68607625
114regulation of development, heterochronic (GO:0040034)2.67666629
115regulation of skeletal muscle contraction (GO:0014819)2.67561819
116notochord development (GO:0030903)2.67270265
117embryonic retina morphogenesis in camera-type eye (GO:0060059)2.66453766
118multicellular organism reproduction (GO:0032504)2.64231262
119establishment of spindle localization (GO:0051293)2.63736973
120pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.62368524
121negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.62337712
122lateral ventricle development (GO:0021670)2.62221179
123regulation of germinal center formation (GO:0002634)2.60993051
124myoblast migration (GO:0051451)2.60472839
125retinoic acid metabolic process (GO:0042573)2.59743643
126regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.59254837
127regulation of G2/M transition of mitotic cell cycle (GO:0010389)2.58815472
128protein complex localization (GO:0031503)2.57696597
129regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.57604430
130regulation of keratinocyte proliferation (GO:0010837)2.57237117
131retina layer formation (GO:0010842)2.54520049
132oogenesis (GO:0048477)2.54472077
133spermatid development (GO:0007286)2.53706601
134type B pancreatic cell development (GO:0003323)2.53037039
135positive regulation of smoothened signaling pathway (GO:0045880)2.51105510
136chromatin assembly or disassembly (GO:0006333)2.50832860
137exogenous drug catabolic process (GO:0042738)2.50004627
138embryonic camera-type eye development (GO:0031076)2.49537635
139oocyte maturation (GO:0001556)2.49195015
140mitotic chromosome condensation (GO:0007076)2.48815298
141regulation of smoothened signaling pathway (GO:0008589)2.48371099
142attachment of spindle microtubules to kinetochore (GO:0008608)2.47750072
143limb development (GO:0060173)2.47020076
144appendage development (GO:0048736)2.47020076
145glutathione derivative metabolic process (GO:1901685)2.45503426
146glutathione derivative biosynthetic process (GO:1901687)2.45503426
147regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.43706458
148drug catabolic process (GO:0042737)2.42618585
149establishment of tissue polarity (GO:0007164)2.42514059
150establishment of planar polarity (GO:0001736)2.42514059
151embryonic body morphogenesis (GO:0010172)2.36518734
152ethanol oxidation (GO:0006069)2.36342740
153hypotonic response (GO:0006971)2.35246258
154heart looping (GO:0001947)2.31365048
155regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.31008694
156regulation of acrosome reaction (GO:0060046)2.30707217
157O-glycan processing (GO:0016266)2.29360575
158lateral sprouting from an epithelium (GO:0060601)2.27324742
159regulation of meiosis I (GO:0060631)2.27132555
160positive regulation of cGMP biosynthetic process (GO:0030828)2.25679408
161single fertilization (GO:0007338)2.25370141
162urinary tract smooth muscle contraction (GO:0014848)2.24927094
163regulation of collateral sprouting (GO:0048670)2.24639434
164benzene-containing compound metabolic process (GO:0042537)2.23993255
165terpenoid biosynthetic process (GO:0016114)2.21236228
166regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.20152658
167* cilium movement (GO:0003341)11.2266916
168axonemal dynein complex assembly (GO:0070286)10.3419705

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human3.47440141
2GBX2_23144817_ChIP-Seq_PC3_Human3.07681464
3VDR_22108803_ChIP-Seq_LS180_Human2.98658272
4E2F7_22180533_ChIP-Seq_HELA_Human2.94508402
5AR_21909140_ChIP-Seq_LNCAP_Human2.63884956
6MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.58676747
7GATA1_26923725_Chip-Seq_HPCs_Mouse2.57242625
8EZH2_22144423_ChIP-Seq_EOC_Human2.50260861
9PCGF2_27294783_Chip-Seq_ESCs_Mouse2.47383513
10E2F4_17652178_ChIP-ChIP_JURKAT_Human2.41757324
11KAP1_22055183_ChIP-Seq_ESCs_Mouse2.37641350
12TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.36556020
13RNF2_27304074_Chip-Seq_NSC_Mouse2.35085098
14POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.34082557
15TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.34082557
16SUZ12_27294783_Chip-Seq_NPCs_Mouse2.27583468
17RBPJ_22232070_ChIP-Seq_NCS_Mouse2.27524316
18FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.26846121
19CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.21695008
20FLI1_27457419_Chip-Seq_LIVER_Mouse2.20546132
21NFE2_27457419_Chip-Seq_LIVER_Mouse2.13695308
22FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.09152310
23FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.09023085
24GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.05968480
25PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.03951448
26TAF15_26573619_Chip-Seq_HEK293_Human2.01304032
27BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.97169239
28TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.95340427
29PCGF2_27294783_Chip-Seq_NPCs_Mouse1.92827945
30AHR_22903824_ChIP-Seq_MCF-7_Human1.83731518
31TOP2B_26459242_ChIP-Seq_MCF-7_Human1.83056747
32LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.77663583
33ZFP57_27257070_Chip-Seq_ESCs_Mouse1.76136750
34ESR1_20079471_ChIP-ChIP_T-47D_Human1.74022995
35ARNT_22903824_ChIP-Seq_MCF-7_Human1.71952491
36SALL1_21062744_ChIP-ChIP_HESCs_Human1.69127247
37TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.68686510
38EZH2_27294783_Chip-Seq_NPCs_Mouse1.68111507
39FUS_26573619_Chip-Seq_HEK293_Human1.67662982
40BCAT_22108803_ChIP-Seq_LS180_Human1.66864411
41NANOG_18555785_Chip-Seq_ESCs_Mouse1.65810093
42AR_21572438_ChIP-Seq_LNCaP_Human1.64108781
43ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.63918705
44EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.63621921
45P300_19829295_ChIP-Seq_ESCs_Human1.62376661
46WDR5_24793694_ChIP-Seq_LNCAP_Human1.62251446
47TP53_18474530_ChIP-ChIP_U2OS_Human1.61874148
48CBX2_27304074_Chip-Seq_ESCs_Mouse1.61021659
49HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.60903627
50SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.59739404
51FOXM1_26456572_ChIP-Seq_MCF-7_Human1.59401379
52CTNNB1_20460455_ChIP-Seq_HCT116_Human1.57606130
53SMAD3_21741376_ChIP-Seq_EPCs_Human1.57016813
54* SMAD4_21799915_ChIP-Seq_A2780_Human1.51721465
55BMI1_23680149_ChIP-Seq_NPCS_Mouse1.51708376
56* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.50705804
57CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.50412508
58OCT4_18555785_Chip-Seq_ESCs_Mouse1.49416120
59CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.49112957
60* TP53_16413492_ChIP-PET_HCT116_Human1.49075293
61CBP_20019798_ChIP-Seq_JUKART_Human1.48982017
62IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.48982017
63P53_22387025_ChIP-Seq_ESCs_Mouse1.47817902
64AR_25329375_ChIP-Seq_VCAP_Human1.47231022
65MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.46358523
66ZNF274_21170338_ChIP-Seq_K562_Hela1.46265211
67EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.45945907
68ZFX_18555785_Chip-Seq_ESCs_Mouse1.44130595
69RUNX1_26923725_Chip-Seq_HPCs_Mouse1.43849848
70* STAT3_23295773_ChIP-Seq_U87_Human1.43308532
71ER_23166858_ChIP-Seq_MCF-7_Human1.42119216
72CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.41943308
73MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.41563693
74RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.41449487
75TCF4_22108803_ChIP-Seq_LS180_Human1.40888044
76SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.40551032
77CTBP2_25329375_ChIP-Seq_LNCAP_Human1.40004738
78NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.39415732
79TP63_23658742_ChIP-Seq_EP156T_Human1.39361861
80CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.39259097
81SMAD_19615063_ChIP-ChIP_OVARY_Human1.38930296
82CDX2_19796622_ChIP-Seq_MESCs_Mouse1.37179517
83NR3C1_21868756_ChIP-Seq_MCF10A_Human1.35639664
84SMAD4_21741376_ChIP-Seq_EPCs_Human1.35584155
85ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.35269176
86UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.34105327
87TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.33711309
88SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33002295
89STAT3_18555785_Chip-Seq_ESCs_Mouse1.32492387
90STAT1_17558387_ChIP-Seq_HELA_Human1.32115665
91SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.31722254
92MYC_18940864_ChIP-ChIP_HL60_Human1.31437144
93LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31427458
94ESRRB_18555785_Chip-Seq_ESCs_Mouse1.31215968
95POU3F2_20337985_ChIP-ChIP_501MEL_Human1.31135951
96TBL1_22424771_ChIP-Seq_293T_Human1.30774256
97TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30595092
98SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.28717704
99IGF1R_20145208_ChIP-Seq_DFB_Human1.27580021
100TP63_19390658_ChIP-ChIP_HaCaT_Human1.27191528
101LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.26612819
102OCT4_21477851_ChIP-Seq_ESCs_Mouse1.26089490
103AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.25852027
104PRDM14_20953172_ChIP-Seq_ESCs_Human1.25055454
105CRX_20693478_ChIP-Seq_RETINA_Mouse1.24920000
106ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.23927402
107SOX2_18555785_Chip-Seq_ESCs_Mouse1.23662648
108SMRT_27268052_Chip-Seq_Bcells_Human1.23641336
109CMYC_18555785_Chip-Seq_ESCs_Mouse1.23630519
110P300_18555785_Chip-Seq_ESCs_Mouse1.22668513
111MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.22539315
112TAL1_26923725_Chip-Seq_HPCs_Mouse1.22438839
113SMAD3_21741376_ChIP-Seq_HESCs_Human1.21978816
114SUZ12_18555785_Chip-Seq_ESCs_Mouse1.21741608
115NMYC_18555785_Chip-Seq_ESCs_Mouse1.21610562
116OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21281099
117DROSHA_22980978_ChIP-Seq_HELA_Human1.21007083
118* TCF4_23295773_ChIP-Seq_U87_Human1.19857482
119CTCF_18555785_Chip-Seq_ESCs_Mouse1.19605490
120NFYA_21822215_ChIP-Seq_K562_Human1.19387578
121TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.18853546
122KLF4_18555785_Chip-Seq_ESCs_Mouse1.18272308
123PIAS1_25552417_ChIP-Seq_VCAP_Human1.17630793
124* CDX2_22108803_ChIP-Seq_LS180_Human1.16645486
125EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.16126057
126ERG_20517297_ChIP-Seq_VCAP_Human1.15058966
127SOX2_21211035_ChIP-Seq_LN229_Gbm1.14479381
128E2F1_18555785_Chip-Seq_ESCs_Mouse1.14374500
129PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.14264214
130PU1_27457419_Chip-Seq_LIVER_Mouse1.13687626
131EP300_21415370_ChIP-Seq_HL-1_Mouse1.13539253
132E2F1_21310950_ChIP-Seq_MCF-7_Human1.12954206
133CJUN_26792858_Chip-Seq_BT549_Human1.11861642
134NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.11601030
135NRF2_20460467_ChIP-Seq_MEFs_Mouse1.11601030
136NFYB_21822215_ChIP-Seq_K562_Human1.11017113
137RUNX2_22187159_ChIP-Seq_PCA_Human1.10803415
138CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.10645668
139AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.10474125
140* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.09154657
141ETV1_20927104_ChIP-Seq_GIST48_Human1.08388721
142CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.07727625
143TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.07383618
144PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.07366386
145ZNF217_24962896_ChIP-Seq_MCF-7_Human1.06175825
146GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.06143119
147FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.06063502
148SMAD4_21741376_ChIP-Seq_HESCs_Human1.05500012
149PHF8_20622853_ChIP-Seq_HELA_Human1.04678642
150EWS_26573619_Chip-Seq_HEK293_Human1.00528245
151* AR_19668381_ChIP-Seq_PC3_Human0.99874876
152SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.97291315
153TBX3_20139965_ChIP-Seq_ESCs_Mouse0.97070953
154RXR_22108803_ChIP-Seq_LS180_Human0.96978716
155RUNX1_27457419_Chip-Seq_LIVER_Mouse0.96681371
156RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.95384634
157TBX3_20139965_ChIP-Seq_MESCs_Mouse0.95095084
158HNFA_21074721_ChIP-Seq_CACO-2_Human0.94597988

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002653_abnormal_ependyma_morphology6.35848350
2MP0003950_abnormal_plasma_membrane4.08625781
3MP0008875_abnormal_xenobiotic_pharmacok3.70345552
4MP0008789_abnormal_olfactory_epithelium3.32708913
5MP0004043_abnormal_pH_regulation2.89667772
6MP0000383_abnormal_hair_follicle2.84218245
7MP0005623_abnormal_meninges_morphology2.72796796
8MP0002168_other_aberrant_phenotype2.71058927
9MP0003787_abnormal_imprinting2.64579118
10MP0003693_abnormal_embryo_hatching2.62940139
11MP0002132_abnormal_respiratory_system2.57916397
12MP0002102_abnormal_ear_morphology2.52187467
13MP0008995_early_reproductive_senescence2.52045339
14MP0005394_taste/olfaction_phenotype2.43178945
15MP0005499_abnormal_olfactory_system2.43178945
16MP0008877_abnormal_DNA_methylation2.36625025
17MP0003136_yellow_coat_color2.36163129
18MP0001984_abnormal_olfaction2.34439826
19MP0004133_heterotaxia2.34408844
20MP0010678_abnormal_skin_adnexa2.25071609
21MP0001929_abnormal_gametogenesis2.19511834
22MP0000566_synostosis2.19238126
23MP0003195_calcinosis2.08274585
24MP0000613_abnormal_salivary_gland2.05728485
25MP0001919_abnormal_reproductive_system2.02257393
26MP0009780_abnormal_chondrocyte_physiolo2.00190825
27MP0001485_abnormal_pinna_reflex1.99281581
28MP0008057_abnormal_DNA_replication1.98768497
29MP0002163_abnormal_gland_morphology1.98291118
30MP0002210_abnormal_sex_determination1.89165054
31MP0003718_maternal_effect1.87598522
32MP0005248_abnormal_Harderian_gland1.84137664
33MP0005646_abnormal_pituitary_gland1.80933437
34MP0003121_genomic_imprinting1.80201323
35MP0005379_endocrine/exocrine_gland_phen1.79791916
36MP0002928_abnormal_bile_duct1.78674844
37MP0003077_abnormal_cell_cycle1.77741156
38MP0003045_fibrosis1.77331697
39MP0002638_abnormal_pupillary_reflex1.77321147
40MP0005551_abnormal_eye_electrophysiolog1.76184661
41MP0006292_abnormal_olfactory_placode1.75826516
42MP0003698_abnormal_male_reproductive1.74713133
43MP0008058_abnormal_DNA_repair1.74137911
44MP0002160_abnormal_reproductive_system1.72547800
45MP0006072_abnormal_retinal_apoptosis1.69749547
46MP0002735_abnormal_chemical_nociception1.69693218
47MP0001346_abnormal_lacrimal_gland1.69062695
48MP0000653_abnormal_sex_gland1.67970045
49MP0010094_abnormal_chromosome_stability1.67947830
50MP0003111_abnormal_nucleus_morphology1.67409522
51MP0005389_reproductive_system_phenotype1.62887548
52MP0005410_abnormal_fertilization1.62416624
53MP0002277_abnormal_respiratory_mucosa1.60490415
54MP0000462_abnormal_digestive_system1.59941761
55MP0003937_abnormal_limbs/digits/tail_de1.59136397
56MP0003890_abnormal_embryonic-extraembry1.57965517
57MP0003878_abnormal_ear_physiology1.57293701
58MP0005377_hearing/vestibular/ear_phenot1.57293701
59MP0001119_abnormal_female_reproductive1.56834337
60MP0005253_abnormal_eye_physiology1.52607046
61MP0010234_abnormal_vibrissa_follicle1.49677366
62MP0003123_paternal_imprinting1.47678181
63MP0004215_abnormal_myocardial_fiber1.45471036
64MP0000678_abnormal_parathyroid_gland1.43490547
65MP0001145_abnormal_male_reproductive1.42715853
66MP0003763_abnormal_thymus_physiology1.40149085
67MP0003252_abnormal_bile_duct1.39374521
68MP0004145_abnormal_muscle_electrophysio1.37373928
69MP0009046_muscle_twitch1.36992026
70MP0000631_abnormal_neuroendocrine_gland1.36302388
71MP0002938_white_spotting1.36194702
72MP0010030_abnormal_orbit_morphology1.31352875
73MP0000427_abnormal_hair_cycle1.28699626
74MP0003699_abnormal_female_reproductive1.27250891
75MP0005220_abnormal_exocrine_pancreas1.26322955
76MP0002161_abnormal_fertility/fecundity1.21522595
77MP0005451_abnormal_body_composition1.19883641
78MP0001944_abnormal_pancreas_morphology1.18917017
79MP0003119_abnormal_digestive_system1.16073551
80MP0000569_abnormal_digit_pigmentation1.15369405
81MP0003656_abnormal_erythrocyte_physiolo1.14212985
82MP0005085_abnormal_gallbladder_physiolo1.10982871
83MP0008932_abnormal_embryonic_tissue1.10670784
84MP0002089_abnormal_postnatal_growth/wei1.10069163
85MP0003942_abnormal_urinary_system1.08993765
86MP0004742_abnormal_vestibular_system1.08729953
87MP0004019_abnormal_vitamin_homeostasis1.07141591
88MP0002249_abnormal_larynx_morphology1.06959799
89MP0003300_gastrointestinal_ulcer1.06330147
90MP0002108_abnormal_muscle_morphology1.01863804
91MP0001664_abnormal_digestion1.01447303
92MP0009379_abnormal_foot_pigmentation1.00522840
93MP0002736_abnormal_nociception_after1.00156164
94MP0010386_abnormal_urinary_bladder0.98253806
95MP0001177_atelectasis0.97564367
96MP0002234_abnormal_pharynx_morphology0.97414019
97MP0002282_abnormal_trachea_morphology0.96933367
98MP0002116_abnormal_craniofacial_bone0.95404944
99MP0000579_abnormal_nail_morphology0.94964861
100MP0005395_other_phenotype0.94841636
101MP0004782_abnormal_surfactant_physiolog0.94126493
102MP0003938_abnormal_ear_development0.94037946
103MP0001324_abnormal_eye_pigmentation0.93954726
104MP0001765_abnormal_ion_homeostasis0.93922249
105MP0009384_cardiac_valve_regurgitation0.93684240
106MP0003283_abnormal_digestive_organ0.93408888
107MP0003183_abnormal_peptide_metabolism0.92744046
108MP0000026_abnormal_inner_ear0.92487634
109MP0002909_abnormal_adrenal_gland0.90385064
110MP0002734_abnormal_mechanical_nocicepti0.89405421
111MP0001879_abnormal_lymphatic_vessel0.89193701
112MP0003861_abnormal_nervous_system0.89047466
113MP0003315_abnormal_perineum_morphology0.88585898
114MP0000432_abnormal_head_morphology0.88397812
115MP0001502_abnormal_circadian_rhythm0.87865757
116MP0001188_hyperpigmentation0.87314496
117MP0005391_vision/eye_phenotype0.86998263
118MP0003115_abnormal_respiratory_system0.86812330
119MP0004957_abnormal_blastocyst_morpholog0.86430373
120MP0000490_abnormal_crypts_of0.85344242
121MP0005381_digestive/alimentary_phenotyp0.85008120
122MP0008004_abnormal_stomach_pH0.83424431
123MP0009250_abnormal_appendicular_skeleto0.82917498
124MP0005503_abnormal_tendon_morphology0.81603727
125MP0001963_abnormal_hearing_physiology0.81280137
126MP0001270_distended_abdomen0.81134083
127MP0002085_abnormal_embryonic_tissue0.81079075
128MP0005195_abnormal_posterior_eye0.80595997
129MP0001663_abnormal_digestive_system0.79993518
130MP0003646_muscle_fatigue0.79945835
131MP0001286_abnormal_eye_development0.79511947
132MP0005310_abnormal_salivary_gland0.77207761
133MP0002098_abnormal_vibrissa_morphology0.77191504
134MP0000428_abnormal_craniofacial_morphol0.77091561
135MP0005645_abnormal_hypothalamus_physiol0.76893849
136MP0001486_abnormal_startle_reflex0.76208652
137MP0002876_abnormal_thyroid_physiology0.76188823
138MP0000049_abnormal_middle_ear0.76040414
139MP0004885_abnormal_endolymph0.75862525
140MP0002184_abnormal_innervation0.75596565
141MP0003879_abnormal_hair_cell0.75126622
142MP0002557_abnormal_social/conspecific_i0.74632503
143MP0004142_abnormal_muscle_tone0.74168186
144MP0010368_abnormal_lymphatic_system0.73318363
145MP0001293_anophthalmia0.72816153
146MP0001756_abnormal_urination0.72710732
147MP0002233_abnormal_nose_morphology0.72054416
148MP0002084_abnormal_developmental_patter0.72034065
149MP0001968_abnormal_touch/_nociception0.66374562
150MP0002229_neurodegeneration0.63732305
151MP0006276_abnormal_autonomic_nervous0.61881355
152MP0002109_abnormal_limb_morphology0.60725949
153MP0001501_abnormal_sleep_pattern0.59480379
154MP0000230_abnormal_systemic_arterial0.58105047
155MP0004085_abnormal_heartbeat0.56864308
156MP0003941_abnormal_skin_development0.56054024
157MP0005620_abnormal_muscle_contractility0.53248106

Predicted human phenotypes

RankGene SetZ-score
1Rhinitis (HP:0012384)8.15867527
2Abnormal respiratory epithelium morphology (HP:0012253)6.82308592
3Abnormal respiratory motile cilium morphology (HP:0005938)6.82308592
4Chronic bronchitis (HP:0004469)6.48689346
5* Bronchiectasis (HP:0002110)5.58266108
6Dynein arm defect of respiratory motile cilia (HP:0012255)5.53366758
7Absent/shortened dynein arms (HP:0200106)5.53366758
8Pancreatic fibrosis (HP:0100732)4.56262275
9True hermaphroditism (HP:0010459)4.25409226
10Bronchitis (HP:0012387)3.61607635
11Abnormality of cochlea (HP:0000375)3.56316282
12Pancreatic cysts (HP:0001737)3.53350453
13Nasal polyposis (HP:0100582)3.48500900
14Male infertility (HP:0003251)3.32938806
15Recurrent sinusitis (HP:0011108)3.24523505
16Cystic liver disease (HP:0006706)3.22024879
17Abnormality of midbrain morphology (HP:0002418)3.21529383
18Molar tooth sign on MRI (HP:0002419)3.21529383
19Occipital encephalocele (HP:0002085)3.20166037
20Infertility (HP:0000789)3.17300160
21Nephronophthisis (HP:0000090)2.99163907
22Median cleft lip (HP:0000161)2.87910333
23Aplasia/Hypoplasia of the tongue (HP:0010295)2.87838957
24Supernumerary spleens (HP:0009799)2.87547107
25Abnormality of the nasal mucosa (HP:0000433)2.85191750
26Bifid tongue (HP:0010297)2.82151230
27Abnormality of the renal medulla (HP:0100957)2.70394466
28Chronic hepatic failure (HP:0100626)2.63338266
29Chronic sinusitis (HP:0011109)2.47180578
30Preaxial hand polydactyly (HP:0001177)2.46451537
31Morphological abnormality of the inner ear (HP:0011390)2.45558092
32Abnormal biliary tract physiology (HP:0012439)2.44603250
33Bile duct proliferation (HP:0001408)2.44603250
34Recurrent otitis media (HP:0000403)2.41782889
35Postaxial foot polydactyly (HP:0001830)2.41445501
36Congenital hepatic fibrosis (HP:0002612)2.40798263
37Chronic otitis media (HP:0000389)2.31996565
38Abnormality of the fingertips (HP:0001211)2.25401586
39Tubulointerstitial fibrosis (HP:0005576)2.25022642
40Anencephaly (HP:0002323)2.11446283
41Tubulointerstitial abnormality (HP:0001969)2.07755002
42Chromsome breakage (HP:0040012)2.04996216
43Bell-shaped thorax (HP:0001591)2.04227878
44Abnormality of chloride homeostasis (HP:0011422)2.01298123
45Respiratory insufficiency due to defective ciliary clearance (HP:0200073)10.2945136
46* Abnormal respiratory motile cilium physiology (HP:0012261)10.1770994
47* Abnormal ciliary motility (HP:0012262)10.1562420
48Male pseudohermaphroditism (HP:0000037)1.99203728
49Genital tract atresia (HP:0001827)1.94775627
50Absent rod-and cone-mediated responses on ERG (HP:0007688)1.94446722
51Medial flaring of the eyebrow (HP:0010747)1.94011900
52Tubulointerstitial nephritis (HP:0001970)1.93736116
53Chromosomal breakage induced by crosslinking agents (HP:0003221)1.92259410
54Facial cleft (HP:0002006)1.92018972
55Abnormality of macular pigmentation (HP:0008002)1.90932170
56Congenital primary aphakia (HP:0007707)1.90143724
57Atelectasis (HP:0100750)1.87023905
58Decreased circulating renin level (HP:0003351)1.86522783
59Abnormality of the renal cortex (HP:0011035)1.82602326
60Oligodactyly (HP:0012165)1.81006084
61Postaxial hand polydactyly (HP:0001162)1.80425630
62Gait imbalance (HP:0002141)1.79330803
63Papillary thyroid carcinoma (HP:0002895)1.78043529
64Shawl scrotum (HP:0000049)1.75271365
65Aplasia involving bones of the upper limbs (HP:0009823)1.75104327
66Aplasia of the phalanges of the hand (HP:0009802)1.75104327
67Aplasia involving bones of the extremities (HP:0009825)1.75104327
68Sclerocornea (HP:0000647)1.74041045
69Absent frontal sinuses (HP:0002688)1.70710610
70Vaginal atresia (HP:0000148)1.70475891
71Recurrent bronchitis (HP:0002837)1.70219828
72Nephrogenic diabetes insipidus (HP:0009806)1.66591961
73Midline defect of the nose (HP:0004122)1.62994792
74Oligodactyly (hands) (HP:0001180)1.60489037
75Abdominal situs inversus (HP:0003363)1.59660759
76Abnormality of abdominal situs (HP:0011620)1.59660759
77Abnormality of permanent molar morphology (HP:0011071)1.59263162
78Abnormality of the dental root (HP:0006486)1.59263162
79Taurodontia (HP:0000679)1.59263162
80Aplasia/Hypoplasia of the sternum (HP:0006714)1.57914047
81Oculomotor apraxia (HP:0000657)1.55116619
82Polydipsia (HP:0001959)1.53918895
83Abnormal drinking behavior (HP:0030082)1.53918895
84Ventricular fibrillation (HP:0001663)1.53576323
85Hyperactive renin-angiotensin system (HP:0000841)1.52104997
86Abnormality of the dental pulp (HP:0006479)1.51674305
87Portal hypertension (HP:0001409)1.50625828
88Hyperkalemia (HP:0002153)1.50500819
89Renal dysplasia (HP:0000110)1.49865843
90Decreased central vision (HP:0007663)1.49702804
91Polycystic kidney dysplasia (HP:0000113)1.47625887
92Microglossia (HP:0000171)1.46008862
93Asplenia (HP:0001746)1.45591100
94Abnormality of molar morphology (HP:0011070)1.44702295
95Abnormality of molar (HP:0011077)1.44702295
96Central scotoma (HP:0000603)1.43610680
97Abnormality of the hepatic vasculature (HP:0006707)1.42165790
98Cone-rod dystrophy (HP:0000548)1.41980025
99Aplasia/Hypoplasia of the spleen (HP:0010451)1.41941961
100Aplasia/Hypoplasia of the earlobes (HP:0009906)1.41576849
101Furrowed tongue (HP:0000221)1.41354908
102Fibular hypoplasia (HP:0003038)1.40567440
103Poor coordination (HP:0002370)1.40219203
104Stage 5 chronic kidney disease (HP:0003774)1.39889579
10511 pairs of ribs (HP:0000878)1.39670657
106Hyperaldosteronism (HP:0000859)1.39341637
107Absent septum pellucidum (HP:0001331)1.39000721
108Abnormality of the septum pellucidum (HP:0007375)1.37943243
109Highly arched eyebrow (HP:0002553)1.37910271
110Abolished electroretinogram (ERG) (HP:0000550)1.37591173
111Tubular atrophy (HP:0000092)1.37423064
112Nephropathy (HP:0000112)1.36783514
113Renal salt wasting (HP:0000127)1.36445460
114Oligohydramnios (HP:0001562)1.36391697
115Lip pit (HP:0100267)1.36344714
116Bony spicule pigmentary retinopathy (HP:0007737)1.35771808
117Intellectual disability, moderate (HP:0002342)1.35497663
118Retinitis pigmentosa (HP:0000510)1.33218746
119Abnormal rod and cone electroretinograms (HP:0008323)1.28602597
120Short thorax (HP:0010306)1.28314728
121Prominent nasal bridge (HP:0000426)1.26378381
122Absent speech (HP:0001344)1.25691096
123Aplasia/Hypoplasia of the lens (HP:0008063)1.24746709
124Gaze-evoked nystagmus (HP:0000640)1.24511741
125Aortic aneurysm (HP:0004942)1.24312808
126Aganglionic megacolon (HP:0002251)1.23528471
127Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.23431070
128Narrow forehead (HP:0000341)1.22776225
129Abnormality of renin-angiotensin system (HP:0000847)1.22700879
130Hypoplastic labia majora (HP:0000059)1.22281449
131Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.22040220
132Multicystic kidney dysplasia (HP:0000003)1.20034087
133Cutaneous finger syndactyly (HP:0010554)1.18771684

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK17.17356499
2MAPK154.91398804
3LATS14.18038847
4STK38L3.53275141
5MYLK3.15617308
6LATS23.03981878
7LMTK22.99880426
8TAOK32.84167123
9PLK42.75670299
10CDC72.44496736
11TTK2.19279555
12MAP3K92.07175042
13VRK12.05974466
14BMPR1B2.04152582
15ACVR1B1.98322544
16STK241.93086536
17PTK2B1.88903078
18PIK3CG1.83107866
19RPS6KA41.59858353
20MAP3K71.57800022
21BRSK21.57342013
22NTRK21.53700747
23STK101.48829087
24NUAK11.48624672
25INSRR1.47321168
26MET1.46581792
27NEK21.44946184
28STK381.39868157
29NLK1.37860538
30PNCK1.31954057
31MAP3K41.31235380
32TRPM71.31126350
33PLK11.21401765
34AURKB1.21261350
35HIPK21.18902300
36ERBB41.18143815
37MAPK131.14682705
38NEK91.10796436
39STK31.08124380
40CDK91.01841279
41MAP3K20.99926654
42MAP4K20.97530543
43BRAF0.97006322
44NME10.96864996
45MAP3K60.96688424
46PASK0.96550703
47CAMKK20.95876705
48PRKD30.95768197
49CHEK20.95614402
50DYRK30.94864353
51ERBB30.94354244
52ADRBK20.89914902
53MOS0.87449739
54MAP3K130.86640623
55ERBB20.86007677
56WEE10.85070227
57CDK80.81304261
58MST1R0.80922178
59EEF2K0.80919641
60ADRBK10.80857288
61EPHA20.79882590
62MUSK0.78353280
63RIPK10.77087515
64CAMK1D0.76203416
65GRK70.75192517
66FRK0.75022058
67FER0.74164822
68AURKA0.73031662
69BCR0.72974911
70ATM0.72166050
71GRK10.68713499
72WNK30.67628993
73STK390.66545358
74KDR0.65602541
75BUB10.63018605
76PBK0.62743359
77CAMK1G0.62658776
78IRAK10.60297535
79CDK30.59917215
80PRKCI0.59779891
81ATR0.58574495
82CAMK2A0.57167851
83MKNK20.56732136
84DAPK20.55534053
85PKN10.52351748
86MARK20.52015229
87PAK60.51691762
88MELK0.51625851
89TGFBR10.50891497
90CHEK10.50738397
91CAMKK10.50201054
92PRKCE0.50049601
93KSR20.49624566
94SRPK10.49130283
95MST40.48262881
96WNK10.48150785
97SGK20.47843914
98MAPKAPK30.47056640
99OXSR10.44230604
100PRKACA0.43336326
101PIK3CA0.43020199
102PRKAA20.43006634
103ROCK20.42972597
104MAP3K80.42969785
105PRKAA10.42601520
106TRIM280.41750631
107ROCK10.40278726
108RPS6KB20.40273242
109ZAK0.40031367
110CAMK2G0.39919478
111PRKDC0.39681608
112IKBKE0.39288143
113CDK120.38846155
114TNK20.38641923
115MAP3K100.38433949
116PRKACB0.38186466
117DMPK0.38184900
118CASK0.35566723
119CDK70.35458413
120CSNK1A1L0.35151020
121ABL10.33986413
122SIK10.33790341
123BRD40.33333843
124TEC0.32236067
125TNIK0.32199508
126NTRK30.31991510
127CDK20.31810392
128PRKCQ0.31664959
129RPS6KA10.31524406
130AKT20.31480872
131SGK10.29655304
132CAMK10.29414638
133EIF2AK20.29348477
134TAOK10.29254908
135RAF10.28964193
136EGFR0.28329293
137MAP2K10.27551836
138CSNK1G10.27255757
139CDK10.26944097
140TIE10.26887403
141PRKCA0.26835457
142NEK60.25392551
143WNK40.25321595
144MAP2K20.25224449
145EIF2AK30.25207086
146CDC42BPA0.25202963
147MAP3K30.25182102
148PRKG10.25113619
149CSNK1E0.24565616
150MAP2K70.24429728
151DYRK1A0.24397460
152MAPK100.23494900

Predicted pathways (KEGG)

RankGene SetZ-score
1Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009803.94613072
2Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.75658796
3Chemical carcinogenesis_Homo sapiens_hsa052043.39079081
4Histidine metabolism_Homo sapiens_hsa003403.24457018
5Basal transcription factors_Homo sapiens_hsa030222.92057520
6Homologous recombination_Homo sapiens_hsa034402.76769418
7Cell cycle_Homo sapiens_hsa041102.75375597
8Fanconi anemia pathway_Homo sapiens_hsa034602.67931574
9RNA degradation_Homo sapiens_hsa030182.58904158
10beta-Alanine metabolism_Homo sapiens_hsa004102.37376302
11Phenylalanine metabolism_Homo sapiens_hsa003602.34392350
12Caffeine metabolism_Homo sapiens_hsa002322.16682758
13Circadian rhythm_Homo sapiens_hsa047102.06674059
14Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.95723509
15Mismatch repair_Homo sapiens_hsa034301.91772899
16Tyrosine metabolism_Homo sapiens_hsa003501.91587315
17Nucleotide excision repair_Homo sapiens_hsa034201.90285122
18Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.88206356
19Steroid hormone biosynthesis_Homo sapiens_hsa001401.88192135
20Thyroid hormone synthesis_Homo sapiens_hsa049181.82357993
21Oocyte meiosis_Homo sapiens_hsa041141.77277328
22Maturity onset diabetes of the young_Homo sapiens_hsa049501.75444470
23Primary bile acid biosynthesis_Homo sapiens_hsa001201.72319531
24Olfactory transduction_Homo sapiens_hsa047401.67596122
25Spliceosome_Homo sapiens_hsa030401.62340990
26DNA replication_Homo sapiens_hsa030301.60400350
27Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.57628827
28Basal cell carcinoma_Homo sapiens_hsa052171.52078525
29RNA transport_Homo sapiens_hsa030131.51503360
30Insulin secretion_Homo sapiens_hsa049111.50523656
31Ovarian steroidogenesis_Homo sapiens_hsa049131.49820593
32Nicotine addiction_Homo sapiens_hsa050331.47527460
33Ribosome_Homo sapiens_hsa030101.45468406
34Glutathione metabolism_Homo sapiens_hsa004801.44512354
35Base excision repair_Homo sapiens_hsa034101.43390636
36alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.41197696
37Hippo signaling pathway_Homo sapiens_hsa043901.40840951
38Linoleic acid metabolism_Homo sapiens_hsa005911.38342471
39Vascular smooth muscle contraction_Homo sapiens_hsa042701.37090467
40Hedgehog signaling pathway_Homo sapiens_hsa043401.33846983
41Pyrimidine metabolism_Homo sapiens_hsa002401.32715013
42Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.30832609
43mRNA surveillance pathway_Homo sapiens_hsa030151.27575291
44Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.26344428
45Dorso-ventral axis formation_Homo sapiens_hsa043201.20571062
46Nitrogen metabolism_Homo sapiens_hsa009101.20100405
47cAMP signaling pathway_Homo sapiens_hsa040241.19302792
48RNA polymerase_Homo sapiens_hsa030201.15763213
49Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.15573780
50Taste transduction_Homo sapiens_hsa047421.14662513
51Estrogen signaling pathway_Homo sapiens_hsa049151.13544932
52Vitamin B6 metabolism_Homo sapiens_hsa007501.13109426
53Tryptophan metabolism_Homo sapiens_hsa003801.11287038
54Non-homologous end-joining_Homo sapiens_hsa034501.10352976
55TGF-beta signaling pathway_Homo sapiens_hsa043501.09517702
56Salivary secretion_Homo sapiens_hsa049701.07434918
57Lysine degradation_Homo sapiens_hsa003101.04801846
58Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.04042402
59Glutamatergic synapse_Homo sapiens_hsa047241.02662469
60Ether lipid metabolism_Homo sapiens_hsa005651.02379782
61Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.02346996
62Aldosterone synthesis and secretion_Homo sapiens_hsa049251.02336694
63Inositol phosphate metabolism_Homo sapiens_hsa005621.00571009
64Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.99936223
65ECM-receptor interaction_Homo sapiens_hsa045120.98523258
66Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.98099748
67Serotonergic synapse_Homo sapiens_hsa047260.97890751
68Wnt signaling pathway_Homo sapiens_hsa043100.97409582
69Pancreatic secretion_Homo sapiens_hsa049720.96957845
70Gastric acid secretion_Homo sapiens_hsa049710.96773984
71Pentose and glucuronate interconversions_Homo sapiens_hsa000400.95684985
72Phosphatidylinositol signaling system_Homo sapiens_hsa040700.95179182
73Starch and sucrose metabolism_Homo sapiens_hsa005000.95035639
74Peroxisome_Homo sapiens_hsa041460.94258268
75Purine metabolism_Homo sapiens_hsa002300.93496350
76p53 signaling pathway_Homo sapiens_hsa041150.91583725
77Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.90959394
78Melanogenesis_Homo sapiens_hsa049160.90897073
79Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.89668059
80Butanoate metabolism_Homo sapiens_hsa006500.89642734
81Amphetamine addiction_Homo sapiens_hsa050310.89345267
82Huntingtons disease_Homo sapiens_hsa050160.89298867
83Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.88639634
84Longevity regulating pathway - mammal_Homo sapiens_hsa042110.87702577
85Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.86992652
86Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.86242225
87Calcium signaling pathway_Homo sapiens_hsa040200.85631281
88Glycerophospholipid metabolism_Homo sapiens_hsa005640.80751852
89Dilated cardiomyopathy_Homo sapiens_hsa054140.80069088
90Notch signaling pathway_Homo sapiens_hsa043300.79162239
91Colorectal cancer_Homo sapiens_hsa052100.78801103
92Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.78323314
93Choline metabolism in cancer_Homo sapiens_hsa052310.77859816
94Arachidonic acid metabolism_Homo sapiens_hsa005900.77511333
95Pancreatic cancer_Homo sapiens_hsa052120.77472028
96HTLV-I infection_Homo sapiens_hsa051660.76890970
97Other glycan degradation_Homo sapiens_hsa005110.76219869
98Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.76085154
99Long-term depression_Homo sapiens_hsa047300.75765768
100Cocaine addiction_Homo sapiens_hsa050300.72891672
101Systemic lupus erythematosus_Homo sapiens_hsa053220.72361295
102Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.72157896
103Carbohydrate digestion and absorption_Homo sapiens_hsa049730.69856014
104Propanoate metabolism_Homo sapiens_hsa006400.68427785
105Fatty acid degradation_Homo sapiens_hsa000710.68221154
106Adherens junction_Homo sapiens_hsa045200.67430150
107Complement and coagulation cascades_Homo sapiens_hsa046100.67258585
108Glycerolipid metabolism_Homo sapiens_hsa005610.66859755
109Thyroid cancer_Homo sapiens_hsa052160.66628456
110Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.65994436
111GnRH signaling pathway_Homo sapiens_hsa049120.63744218
112Oxytocin signaling pathway_Homo sapiens_hsa049210.61215322
113Prostate cancer_Homo sapiens_hsa052150.58365530
114Circadian entrainment_Homo sapiens_hsa047130.57261136
115Transcriptional misregulation in cancer_Homo sapiens_hsa052020.56821478
116AMPK signaling pathway_Homo sapiens_hsa041520.56365338
117Bladder cancer_Homo sapiens_hsa052190.55673401
118cGMP-PKG signaling pathway_Homo sapiens_hsa040220.54394525
119Alcoholism_Homo sapiens_hsa050340.54190749
120Pathways in cancer_Homo sapiens_hsa052000.52700819
121Endometrial cancer_Homo sapiens_hsa052130.52370851
122Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.51911904
123Drug metabolism - other enzymes_Homo sapiens_hsa009830.51666305
124MicroRNAs in cancer_Homo sapiens_hsa052060.50919393
125Renin secretion_Homo sapiens_hsa049240.50452416
126ABC transporters_Homo sapiens_hsa020100.49231228
127Glucagon signaling pathway_Homo sapiens_hsa049220.47776894
128Morphine addiction_Homo sapiens_hsa050320.46867254
129Bile secretion_Homo sapiens_hsa049760.46600597
130Herpes simplex infection_Homo sapiens_hsa051680.46266327
131Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.45949948
132Tight junction_Homo sapiens_hsa045300.45858014
133Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.43487117
134Thyroid hormone signaling pathway_Homo sapiens_hsa049190.42195439
135Long-term potentiation_Homo sapiens_hsa047200.40817777
136Focal adhesion_Homo sapiens_hsa045100.40338410
137Pentose phosphate pathway_Homo sapiens_hsa000300.40056259
138Prolactin signaling pathway_Homo sapiens_hsa049170.39982250
139Mineral absorption_Homo sapiens_hsa049780.39459879
140Retinol metabolism_Homo sapiens_hsa008300.37614072
141Sphingolipid metabolism_Homo sapiens_hsa006000.37456964
142Phototransduction_Homo sapiens_hsa047440.36278007
143Protein digestion and absorption_Homo sapiens_hsa049740.34864082
144Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.34530482
145Gap junction_Homo sapiens_hsa045400.33477630
146GABAergic synapse_Homo sapiens_hsa047270.33023934
147Regulation of actin cytoskeleton_Homo sapiens_hsa048100.26868058
148Metabolic pathways_Homo sapiens_hsa011000.25594010
149Cysteine and methionine metabolism_Homo sapiens_hsa002700.23590576
150Vitamin digestion and absorption_Homo sapiens_hsa049770.22557606

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