DNAH14

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Dyneins are microtubule-associated motor protein complexes composed of several heavy, light, and intermediate chains. Two major classes of dyneins, axonemal and cytoplasmic, have been identified. DNAH14 is an axonemal dynein heavy chain (DHC) (Vaughan et al., 1996 [PubMed 8812413]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1piRNA metabolic process (GO:0034587)8.63107918
2fusion of sperm to egg plasma membrane (GO:0007342)7.77045652
3axonemal dynein complex assembly (GO:0070286)7.50806852
4male meiosis (GO:0007140)6.80220889
5multicellular organism reproduction (GO:0032504)6.72526553
6epithelial cilium movement (GO:0003351)6.63336862
7motile cilium assembly (GO:0044458)6.56054183
8sperm motility (GO:0030317)6.52906072
9sperm-egg recognition (GO:0035036)6.49850651
10acrosome assembly (GO:0001675)6.29647961
11epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.07786853
12cilium movement (GO:0003341)6.07135866
13binding of sperm to zona pellucida (GO:0007339)6.05290375
14DNA methylation involved in gamete generation (GO:0043046)5.85046577
15cell-cell recognition (GO:0009988)5.84308411
16plasma membrane fusion (GO:0045026)5.70101440
17synaptonemal complex organization (GO:0070193)5.62758208
18spermatid development (GO:0007286)5.49376398
19synaptonemal complex assembly (GO:0007130)5.34678393
20male meiosis I (GO:0007141)5.33424286
21reproduction (GO:0000003)5.23090568
22acrosome reaction (GO:0007340)5.13660250
23chromosome organization involved in meiosis (GO:0070192)4.97968513
24meiotic cell cycle (GO:0051321)4.89487150
25single fertilization (GO:0007338)4.66624703
26kinetochore organization (GO:0051383)4.59995916
27regulation of cilium movement (GO:0003352)4.58025221
28meiotic nuclear division (GO:0007126)4.54692274
29meiosis I (GO:0007127)4.53008231
30microtubule depolymerization (GO:0007019)4.47322684
31centriole replication (GO:0007099)4.14263493
32cell wall macromolecule catabolic process (GO:0016998)4.07144639
33cell wall macromolecule metabolic process (GO:0044036)4.07144639
34centriole assembly (GO:0098534)4.04225771
35sperm capacitation (GO:0048240)4.01446780
36synapsis (GO:0007129)3.99638068
37meiotic chromosome segregation (GO:0045132)3.98730283
38kinetochore assembly (GO:0051382)3.97294156
39fertilization (GO:0009566)3.95131207
40histone exchange (GO:0043486)3.93128466
41chromatin remodeling at centromere (GO:0031055)3.77857971
42regulation of nuclear cell cycle DNA replication (GO:0033262)3.74821318
43CENP-A containing nucleosome assembly (GO:0034080)3.60707297
44nuclear pore complex assembly (GO:0051292)3.57774335
45regulation of centriole replication (GO:0046599)3.52990047
46ventricular system development (GO:0021591)3.51460010
47replication fork processing (GO:0031297)3.50732543
48spermatogenesis (GO:0007283)3.49797683
49male gamete generation (GO:0048232)3.49409705
50meiotic cell cycle process (GO:1903046)3.48254304
51intraciliary transport (GO:0042073)3.43758613
52germ cell development (GO:0007281)3.40633777
53DNA ligation (GO:0006266)3.28686774
54behavioral response to nicotine (GO:0035095)3.27821580
55protein localization to chromosome, centromeric region (GO:0071459)3.26766839
56gamete generation (GO:0007276)3.25391358
57cellular process involved in reproduction in multicellular organism (GO:0022412)3.25222718
58response to pheromone (GO:0019236)3.21229412
59GTP biosynthetic process (GO:0006183)3.16414918
60nuclear pore organization (GO:0006999)3.12645260
61double-strand break repair via homologous recombination (GO:0000724)3.11793524
62recombinational repair (GO:0000725)3.11422832
63gene silencing by RNA (GO:0031047)3.10845852
64mitotic sister chromatid segregation (GO:0000070)3.08573026
65DNA replication-independent nucleosome organization (GO:0034724)3.08566765
66DNA replication-independent nucleosome assembly (GO:0006336)3.08566765
67attachment of spindle microtubules to kinetochore (GO:0008608)3.08124818
68pore complex assembly (GO:0046931)3.06394829
69protein polyglutamylation (GO:0018095)3.06364227
70ribosomal small subunit assembly (GO:0000028)3.05094608
71monoubiquitinated protein deubiquitination (GO:0035520)3.05001589
72intra-S DNA damage checkpoint (GO:0031573)3.04058241
73DNA synthesis involved in DNA repair (GO:0000731)3.00731804
74resolution of meiotic recombination intermediates (GO:0000712)3.00119001
75rRNA methylation (GO:0031167)2.99885744
76regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.98966475
77regulation of mitotic spindle checkpoint (GO:1903504)2.98966475
78seminiferous tubule development (GO:0072520)2.98748140
79respiratory chain complex IV assembly (GO:0008535)2.98086329
80DNA double-strand break processing (GO:0000729)2.97511331
81mitotic metaphase plate congression (GO:0007080)2.97499952
82sister chromatid cohesion (GO:0007062)2.97296385
83rRNA modification (GO:0000154)2.97090161
84reciprocal DNA recombination (GO:0035825)2.96233119
85reciprocal meiotic recombination (GO:0007131)2.96233119
86metaphase plate congression (GO:0051310)2.95817849
87regulation of spindle checkpoint (GO:0090231)2.95321271
88regulation of meiosis I (GO:0060631)2.89941808
89DNA replication checkpoint (GO:0000076)2.89743045
90protein K6-linked ubiquitination (GO:0085020)2.88575646
91mitotic sister chromatid cohesion (GO:0007064)2.88472364
92negative regulation of inclusion body assembly (GO:0090084)2.87202032
93protein localization to cilium (GO:0061512)2.85848294
94axoneme assembly (GO:0035082)2.84747661
95establishment of chromosome localization (GO:0051303)2.81876974
96telomere maintenance via recombination (GO:0000722)2.78867949
97left/right pattern formation (GO:0060972)2.78016136
98maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.77603005
99cellular response to gamma radiation (GO:0071480)2.76307636
100establishment of protein localization to Golgi (GO:0072600)2.75889581
101telomere maintenance via semi-conservative replication (GO:0032201)2.73874190
102DNA packaging (GO:0006323)2.73321820
103regulation of mitochondrial translation (GO:0070129)2.73083141
104mitotic chromosome condensation (GO:0007076)2.70573906
105chromosome organization (GO:0051276)2.69458379
106negative regulation of DNA-dependent DNA replication (GO:2000104)2.69163363
107UTP biosynthetic process (GO:0006228)2.68521792
108ribosomal large subunit biogenesis (GO:0042273)2.68038903
109DNA deamination (GO:0045006)2.67680436
110microtubule polymerization or depolymerization (GO:0031109)2.67025859
111regulation of centrosome duplication (GO:0010824)2.66980420
112sister chromatid segregation (GO:0000819)2.65285177
113mitotic recombination (GO:0006312)2.64598296
114DNA replication-dependent nucleosome assembly (GO:0006335)2.63315243
115DNA replication-dependent nucleosome organization (GO:0034723)2.63315243
116pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.62615688
117regulation of centrosome cycle (GO:0046605)2.61677356
118protein targeting to Golgi (GO:0000042)2.57474275
119cellular ketone body metabolic process (GO:0046950)2.56946306
120centrosome organization (GO:0051297)2.56011843
121regulation of DNA endoreduplication (GO:0032875)2.54227750
122mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.52152212
123mitochondrial respiratory chain complex I assembly (GO:0032981)2.52152212
124NADH dehydrogenase complex assembly (GO:0010257)2.52152212
125mitochondrial respiratory chain complex assembly (GO:0033108)2.50662535
126pseudouridine synthesis (GO:0001522)2.49692867
127protein complex biogenesis (GO:0070271)2.49303612
128cytochrome complex assembly (GO:0017004)2.48632890
129microtubule organizing center organization (GO:0031023)2.45203850
130nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.43874617
131ketone body metabolic process (GO:1902224)2.43520927
132exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.43429892
133cilium organization (GO:0044782)2.42418918
134negative regulation of translation, ncRNA-mediated (GO:0040033)2.41704978
135regulation of translation, ncRNA-mediated (GO:0045974)2.41704978
136negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.41704978
137cilium assembly (GO:0042384)2.40466482
138spermatid nucleus differentiation (GO:0007289)2.38634976
139single strand break repair (GO:0000012)2.37454619
140somatic diversification of immune receptors via somatic mutation (GO:0002566)2.37027604
141somatic hypermutation of immunoglobulin genes (GO:0016446)2.37027604
142proteasome assembly (GO:0043248)2.35460847
143peptidyl-histidine modification (GO:0018202)2.35410441
144retrograde transport, vesicle recycling within Golgi (GO:0000301)2.35294524
145protein localization to Golgi apparatus (GO:0034067)2.33247493
146detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.32912481
147DNA integration (GO:0015074)2.31545131
148nonmotile primary cilium assembly (GO:0035058)2.31145505
149non-recombinational repair (GO:0000726)2.28931733
150double-strand break repair via nonhomologous end joining (GO:0006303)2.28931733
151regulation of hexokinase activity (GO:1903299)2.28176555
152regulation of glucokinase activity (GO:0033131)2.28176555
153protein-cofactor linkage (GO:0018065)2.27777875
154photoreceptor cell maintenance (GO:0045494)2.26825853
155ncRNA catabolic process (GO:0034661)2.26487955
156cilium or flagellum-dependent cell motility (GO:0001539)12.8212294

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse8.15028579
2E2F7_22180533_ChIP-Seq_HELA_Human5.51908083
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.66708090
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.38295830
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.33151865
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.22561089
7ZNF274_21170338_ChIP-Seq_K562_Hela3.12124173
8CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.97895129
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.96257544
10FLI1_27457419_Chip-Seq_LIVER_Mouse2.91933126
11PCGF2_27294783_Chip-Seq_ESCs_Mouse2.82055809
12SALL1_21062744_ChIP-ChIP_HESCs_Human2.81880826
13EWS_26573619_Chip-Seq_HEK293_Human2.53261393
14KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.51775575
15SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.42797645
16MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.35794464
17GBX2_23144817_ChIP-Seq_PC3_Human2.26651904
18TAF15_26573619_Chip-Seq_HEK293_Human2.25069504
19EZH2_22144423_ChIP-Seq_EOC_Human2.20446827
20* CTBP2_25329375_ChIP-Seq_LNCAP_Human2.19017343
21NFE2_27457419_Chip-Seq_LIVER_Mouse2.09669266
22PCGF2_27294783_Chip-Seq_NPCs_Mouse2.01025853
23E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.97180309
24P300_19829295_ChIP-Seq_ESCs_Human1.93380922
25SUZ12_27294783_Chip-Seq_NPCs_Mouse1.92149856
26EST1_17652178_ChIP-ChIP_JURKAT_Human1.87520922
27CTBP1_25329375_ChIP-Seq_LNCAP_Human1.83765012
28VDR_22108803_ChIP-Seq_LS180_Human1.74170261
29BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.72380198
30CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.69868160
31ER_23166858_ChIP-Seq_MCF-7_Human1.64818204
32KAP1_22055183_ChIP-Seq_ESCs_Mouse1.64749770
33GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.64526573
34EZH2_27294783_Chip-Seq_NPCs_Mouse1.60690258
35GABP_17652178_ChIP-ChIP_JURKAT_Human1.60647302
36MYC_18555785_ChIP-Seq_MESCs_Mouse1.60626315
37HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.60501536
38UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.59485153
39VDR_23849224_ChIP-Seq_CD4+_Human1.57595844
40JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.56567210
41* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.54195792
42CBP_20019798_ChIP-Seq_JUKART_Human1.51471547
43IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.51471547
44MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.45446117
45TP63_19390658_ChIP-ChIP_HaCaT_Human1.42882505
46CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.40388608
47HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.39722275
48SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.38419466
49FOXP3_21729870_ChIP-Seq_TREG_Human1.38072035
50PADI4_21655091_ChIP-ChIP_MCF-7_Human1.37945652
51MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.37873882
52PIAS1_25552417_ChIP-Seq_VCAP_Human1.37180499
53STAT3_18555785_Chip-Seq_ESCs_Mouse1.36343700
54CBX2_27304074_Chip-Seq_ESCs_Mouse1.35585674
55RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.34992748
56* STAT3_23295773_ChIP-Seq_U87_Human1.33569854
57* SMAD4_21799915_ChIP-Seq_A2780_Human1.33553979
58BMI1_23680149_ChIP-Seq_NPCS_Mouse1.33279910
59OCT4_18555785_Chip-Seq_ESCs_Mouse1.33171265
60IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.32668898
61CREB1_15753290_ChIP-ChIP_HEK293T_Human1.32179540
62ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.31454755
63MYC_18358816_ChIP-ChIP_MESCs_Mouse1.30896243
64ELF1_17652178_ChIP-ChIP_JURKAT_Human1.30337351
65HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.29349895
66SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.28321384
67SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.27747348
68AR_25329375_ChIP-Seq_VCAP_Human1.27177582
69CRX_20693478_ChIP-Seq_RETINA_Mouse1.26869866
70P300_18555785_Chip-Seq_ESCs_Mouse1.26850746
71ETS1_20019798_ChIP-Seq_JURKAT_Human1.26795723
72IRF8_21731497_ChIP-ChIP_J774_Mouse1.26327721
73EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.26259634
74TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25067467
75POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.25067467
76ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.24967464
77P53_22387025_ChIP-Seq_ESCs_Mouse1.24955504
78SUZ12_18555785_Chip-Seq_ESCs_Mouse1.24605026
79CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.24574634
80AR_21909140_ChIP-Seq_LNCAP_Human1.24569176
81EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.23761426
82RUNX1_27457419_Chip-Seq_LIVER_Mouse1.22992882
83SMAD3_21741376_ChIP-Seq_EPCs_Human1.22898411
84TOP2B_26459242_ChIP-Seq_MCF-7_Human1.22246098
85NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.20938004
86MYC_18940864_ChIP-ChIP_HL60_Human1.20540564
87FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.20469288
88MYC_19030024_ChIP-ChIP_MESCs_Mouse1.20252306
89ZFX_18555785_Chip-Seq_ESCs_Mouse1.18823731
90KLF4_18555785_Chip-Seq_ESCs_Mouse1.18544905
91SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.18485150
92NMYC_18555785_Chip-Seq_ESCs_Mouse1.16842326
93E2F1_21310950_ChIP-Seq_MCF-7_Human1.16413690
94PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16337002
95TP53_22573176_ChIP-Seq_HFKS_Human1.16330613
96SRF_21415370_ChIP-Seq_HL-1_Mouse1.16253664
97* TCF4_23295773_ChIP-Seq_U87_Human1.15733479
98DCP1A_22483619_ChIP-Seq_HELA_Human1.15596480
99STAT1_17558387_ChIP-Seq_HELA_Human1.14928927
100TTF2_22483619_ChIP-Seq_HELA_Human1.14521947
101ELK1_19687146_ChIP-ChIP_HELA_Human1.14012536
102TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.13370163
103ESRRB_18555785_Chip-Seq_ESCs_Mouse1.13341678
104* EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.12735151
105POU5F1_16153702_ChIP-ChIP_HESCs_Human1.11845254
106KLF5_20875108_ChIP-Seq_MESCs_Mouse1.11599640
107NR3C1_21868756_ChIP-Seq_MCF10A_Human1.10958270
108NANOG_18555785_Chip-Seq_ESCs_Mouse1.10834989
109RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.08628355
110RUNX2_22187159_ChIP-Seq_PCA_Human1.08397403
111PU1_27457419_Chip-Seq_LIVER_Mouse1.08357193
112CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.08227032
113* SOX2_19829295_ChIP-Seq_ESCs_Human1.07438980
114* NANOG_19829295_ChIP-Seq_ESCs_Human1.07438980
115OCT4_21477851_ChIP-Seq_ESCs_Mouse1.07365377
116GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.07361454
117TAL1_26923725_Chip-Seq_HPCs_Mouse1.07122543
118E2F1_18555785_Chip-Seq_ESCs_Mouse1.07083938
119* TCF4_22108803_ChIP-Seq_LS180_Human1.07035195
120RBPJ_22232070_ChIP-Seq_NCS_Mouse1.06741084
121GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06381261
122NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.05919404
123ZFP57_27257070_Chip-Seq_ESCs_Mouse1.04352958
124MYC_19079543_ChIP-ChIP_MESCs_Mouse1.03374111
125TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.03262634
126SOX2_18555785_Chip-Seq_ESCs_Mouse1.02418269
127SMAD1_18555785_Chip-Seq_ESCs_Mouse1.02275634
128AR_21572438_ChIP-Seq_LNCaP_Human1.01503065
129XRN2_22483619_ChIP-Seq_HELA_Human1.01444022
130CMYC_18555785_Chip-Seq_ESCs_Mouse1.00901780
131PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.00801264
132FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.00332159
133* SMAD4_21741376_ChIP-Seq_EPCs_Human1.00210494
134HOXB4_20404135_ChIP-ChIP_EML_Mouse0.99976922
135* PHF8_20622853_ChIP-Seq_HELA_Human0.99070685
136CTCF_18555785_Chip-Seq_ESCs_Mouse0.98425904
137* ETV1_20927104_ChIP-Seq_GIST48_Human0.97604593
138IRF1_19129219_ChIP-ChIP_H3396_Human0.97362470
139JUN_21703547_ChIP-Seq_K562_Human0.97089789
140* NFYB_21822215_ChIP-Seq_K562_Human0.97026347
141NOTCH1_21737748_ChIP-Seq_TLL_Human0.96545284
142FOXA1_25329375_ChIP-Seq_VCAP_Human0.95492306
143FOXA1_27270436_Chip-Seq_PROSTATE_Human0.95492306
144MYCN_18555785_ChIP-Seq_MESCs_Mouse0.92308660
145IGF1R_20145208_ChIP-Seq_DFB_Human0.89421739
146MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.89216767
147FUS_26573619_Chip-Seq_HEK293_Human0.89046030
148SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.88279712
149KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.86797419
150TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.86066785
151EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.85943718
152SPI1_23547873_ChIP-Seq_NB4_Human0.85479448
153ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.84816522
154RNF2_27304074_Chip-Seq_NSC_Mouse0.84786665
155STAT4_19710469_ChIP-ChIP_TH1__Mouse0.83737219
156POU3F2_20337985_ChIP-ChIP_501MEL_Human0.83282073

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization7.41814138
2MP0008877_abnormal_DNA_methylation4.72381396
3MP0008057_abnormal_DNA_replication3.82014950
4MP0003693_abnormal_embryo_hatching3.69565602
5MP0001929_abnormal_gametogenesis3.61867770
6MP0003698_abnormal_male_reproductive3.50864051
7MP0010094_abnormal_chromosome_stability3.46119557
8MP0002210_abnormal_sex_determination3.12203888
9MP0008058_abnormal_DNA_repair2.89825916
10MP0000569_abnormal_digit_pigmentation2.77795615
11MP0008007_abnormal_cellular_replicative2.72254036
12MP0002234_abnormal_pharynx_morphology2.57028884
13MP0003111_abnormal_nucleus_morphology2.51416075
14MP0001145_abnormal_male_reproductive2.45849467
15MP0005174_abnormal_tail_pigmentation2.44908026
16MP0000015_abnormal_ear_pigmentation2.40938029
17MP0000653_abnormal_sex_gland2.20539961
18MP0003786_premature_aging2.18103880
19MP0009379_abnormal_foot_pigmentation2.16421343
20MP0003077_abnormal_cell_cycle2.13582543
21MP0003136_yellow_coat_color2.08805983
22MP0002160_abnormal_reproductive_system2.01993827
23MP0003646_muscle_fatigue2.00036785
24MP0002161_abnormal_fertility/fecundity1.82837727
25MP0003890_abnormal_embryonic-extraembry1.79432369
26MP0003937_abnormal_limbs/digits/tail_de1.75570721
27MP0004957_abnormal_blastocyst_morpholog1.73987717
28MP0003763_abnormal_thymus_physiology1.70916334
29MP0005551_abnormal_eye_electrophysiolog1.67273953
30MP0002653_abnormal_ependyma_morphology1.66496531
31MP0006072_abnormal_retinal_apoptosis1.63933678
32MP0002132_abnormal_respiratory_system1.62587796
33MP0000631_abnormal_neuroendocrine_gland1.62502567
34MP0005645_abnormal_hypothalamus_physiol1.60340020
35MP0001293_anophthalmia1.56693135
36MP0004808_abnormal_hematopoietic_stem1.55245478
37MP0005253_abnormal_eye_physiology1.51546057
38MP0004381_abnormal_hair_follicle1.50665157
39MP0001835_abnormal_antigen_presentation1.49205967
40MP0006276_abnormal_autonomic_nervous1.44414213
41MP0005646_abnormal_pituitary_gland1.43883684
42MP0008995_early_reproductive_senescence1.39563385
43MP0008932_abnormal_embryonic_tissue1.39490056
44MP0003195_calcinosis1.39041564
45MP0002095_abnormal_skin_pigmentation1.37581369
46MP0004043_abnormal_pH_regulation1.37387169
47MP0000490_abnormal_crypts_of1.36874860
48MP0005389_reproductive_system_phenotype1.36227216
49MP0005075_abnormal_melanosome_morpholog1.35350561
50MP0006292_abnormal_olfactory_placode1.34707423
51MP0001188_hyperpigmentation1.33222733
52MP0004133_heterotaxia1.32590040
53MP0001529_abnormal_vocalization1.29512513
54MP0002396_abnormal_hematopoietic_system1.26960216
55MP0001485_abnormal_pinna_reflex1.26863114
56MP0003121_genomic_imprinting1.25998220
57MP0003283_abnormal_digestive_organ1.24551975
58MP0002638_abnormal_pupillary_reflex1.23040280
59MP0003119_abnormal_digestive_system1.22306219
60MP0005409_darkened_coat_color1.21762459
61MP0009697_abnormal_copulation1.20148269
62MP0002009_preneoplasia1.17775546
63MP0001286_abnormal_eye_development1.17682047
64MP0009046_muscle_twitch1.17498993
65MP0002736_abnormal_nociception_after1.17206449
66MP0000372_irregular_coat_pigmentation1.14952957
67MP0002837_dystrophic_cardiac_calcinosis1.13925922
68MP0002233_abnormal_nose_morphology1.12146943
69MP0000566_synostosis1.12100474
70MP0001119_abnormal_female_reproductive1.11551582
71MP0008872_abnormal_physiological_respon1.11193012
72MP0003878_abnormal_ear_physiology1.10912632
73MP0005377_hearing/vestibular/ear_phenot1.10912632
74MP0001986_abnormal_taste_sensitivity1.09875334
75MP0005187_abnormal_penis_morphology1.09103532
76MP0000427_abnormal_hair_cycle1.07504641
77MP0003315_abnormal_perineum_morphology1.04585429
78MP0003011_delayed_dark_adaptation1.04187994
79MP0000383_abnormal_hair_follicle1.04041551
80MP0005671_abnormal_response_to1.02530137
81MP0001545_abnormal_hematopoietic_system1.01984352
82MP0005397_hematopoietic_system_phenotyp1.01984352
83MP0005391_vision/eye_phenotype1.00133182
84MP0000778_abnormal_nervous_system0.99404543
85MP0001968_abnormal_touch/_nociception0.96915867
86MP0003880_abnormal_central_pattern0.95206664
87MP0010030_abnormal_orbit_morphology0.93845170
88MP0000313_abnormal_cell_death0.93321828
89MP0000647_abnormal_sebaceous_gland0.92623148
90MP0002928_abnormal_bile_duct0.91646789
91MP0005367_renal/urinary_system_phenotyp0.90828971
92MP0000516_abnormal_urinary_system0.90828971
93MP0002876_abnormal_thyroid_physiology0.90652545
94MP0002398_abnormal_bone_marrow0.90236642
95MP0003122_maternal_imprinting0.89265382
96MP0004142_abnormal_muscle_tone0.89062156
97MP0005623_abnormal_meninges_morphology0.88504120
98MP0002277_abnormal_respiratory_mucosa0.88142765
99MP0001324_abnormal_eye_pigmentation0.87302280
100MP0002184_abnormal_innervation0.86806601
101MP0005025_abnormal_response_to0.86437956
102MP0002148_abnormal_hypersensitivity_rea0.85806669
103MP0002557_abnormal_social/conspecific_i0.85662386
104MP0009333_abnormal_splenocyte_physiolog0.85450136
105MP0002751_abnormal_autonomic_nervous0.85393491
106MP0003787_abnormal_imprinting0.85068511
107MP0002084_abnormal_developmental_patter0.84482155
108MP0005195_abnormal_posterior_eye0.84223706
109MP0002697_abnormal_eye_size0.83854209
110MP0001486_abnormal_startle_reflex0.83708158
111MP0009785_altered_susceptibility_to0.82647491
112MP0002822_catalepsy0.81328946
113MP0001764_abnormal_homeostasis0.80927719
114MP0002938_white_spotting0.80622788
115MP0000049_abnormal_middle_ear0.80531612
116MP0009745_abnormal_behavioral_response0.80178318
117MP0002752_abnormal_somatic_nervous0.79845768
118MP0005084_abnormal_gallbladder_morpholo0.79408233
119MP0001919_abnormal_reproductive_system0.79247623
120MP0003567_abnormal_fetal_cardiomyocyte0.79151866
121MP0004134_abnormal_chest_morphology0.79145096
122MP0000955_abnormal_spinal_cord0.79140291
123MP0002019_abnormal_tumor_incidence0.77787036
124MP0001984_abnormal_olfaction0.77740650
125MP0002272_abnormal_nervous_system0.76503493
126MP0000703_abnormal_thymus_morphology0.75729750
127MP0004147_increased_porphyrin_level0.74618896
128MP0003718_maternal_effect0.73380572
129MP0002006_tumorigenesis0.73343192
130MP0002282_abnormal_trachea_morphology0.73182825
131MP0005647_abnormal_sex_gland0.72997053
132MP0002102_abnormal_ear_morphology0.72286636
133MP0002452_abnormal_antigen_presenting0.72268020
134MP0002405_respiratory_system_inflammati0.71379855
135MP0002420_abnormal_adaptive_immunity0.71099824
136MP0001819_abnormal_immune_cell0.70890417
137MP0000689_abnormal_spleen_morphology0.69769314
138MP0002723_abnormal_immune_serum0.67599208
139MP0000716_abnormal_immune_system0.67522755
140MP0001800_abnormal_humoral_immune0.66839144
141MP0001853_heart_inflammation0.66616394
142MP0002722_abnormal_immune_system0.65002975
143MP0002429_abnormal_blood_cell0.63984738
144MP0005408_hypopigmentation0.59379593
145MP0002163_abnormal_gland_morphology0.58826208
146MP0002166_altered_tumor_susceptibility0.58271436
147MP0010307_abnormal_tumor_latency0.57769301
148MP0005000_abnormal_immune_tolerance0.57503017
149MP0002419_abnormal_innate_immunity0.55711215
150MP0000350_abnormal_cell_proliferation0.54925546
151MP0010155_abnormal_intestine_physiology0.54305311
152MP0002177_abnormal_outer_ear0.53679753
153MP0003943_abnormal_hepatobiliary_system0.53396478
154MP0003724_increased_susceptibility_to0.53224944
155MP0003699_abnormal_female_reproductive0.49221012
156MP0005464_abnormal_platelet_physiology0.48340995
157MP0005171_absent_coat_pigmentation0.48175570
158MP0001186_pigmentation_phenotype0.46626370
159MP0003436_decreased_susceptibility_to0.45482883

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)9.93051257
2Absent/shortened dynein arms (HP:0200106)8.90429266
3Dynein arm defect of respiratory motile cilia (HP:0012255)8.90429266
4Abnormal respiratory motile cilium physiology (HP:0012261)7.00292218
5Abnormal respiratory epithelium morphology (HP:0012253)6.64023034
6Abnormal respiratory motile cilium morphology (HP:0005938)6.64023034
7Abnormal ciliary motility (HP:0012262)6.06151240
8Rhinitis (HP:0012384)5.73924682
9Chronic bronchitis (HP:0004469)4.63449320
10Nasal polyposis (HP:0100582)4.22125738
1111 pairs of ribs (HP:0000878)4.01476631
12Infertility (HP:0000789)3.98008062
13Pancreatic cysts (HP:0001737)3.96937759
14Bronchiectasis (HP:0002110)3.93704444
15Chromsome breakage (HP:0040012)3.74639883
16Chromosomal breakage induced by crosslinking agents (HP:0003221)3.67904456
17Nephronophthisis (HP:0000090)3.57055501
18Bronchitis (HP:0012387)3.43829888
19Abnormality of the nasal mucosa (HP:0000433)3.34656361
20Tubulointerstitial nephritis (HP:0001970)3.33955479
21Chronic hepatic failure (HP:0100626)3.26364665
22Recurrent sinusitis (HP:0011108)3.03731223
23Abnormality of the preputium (HP:0100587)2.96311713
24Abnormal spermatogenesis (HP:0008669)2.90692334
25Abnormality of the renal medulla (HP:0100957)2.89936150
26Meckel diverticulum (HP:0002245)2.83973079
27Aplasia/Hypoplasia of the uvula (HP:0010293)2.75926554
28Abnormality of the anterior horn cell (HP:0006802)2.75727409
29Degeneration of anterior horn cells (HP:0002398)2.75727409
30Abnormality of chromosome stability (HP:0003220)2.74757866
31Abnormality of the ileum (HP:0001549)2.68447544
32Impulsivity (HP:0100710)2.68186029
33Gonadotropin excess (HP:0000837)2.67641436
34Ectopic kidney (HP:0000086)2.64561309
35Recurrent bronchitis (HP:0002837)2.64083599
36Reticulocytopenia (HP:0001896)2.61893222
37Recurrent otitis media (HP:0000403)2.56841881
38Azoospermia (HP:0000027)2.54091376
39Nephroblastoma (Wilms tumor) (HP:0002667)2.50541820
40Postaxial foot polydactyly (HP:0001830)2.45201724
41Abnormality of alanine metabolism (HP:0010916)2.43243096
42Hyperalaninemia (HP:0003348)2.43243096
43Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.43243096
44J-shaped sella turcica (HP:0002680)2.40428090
45Supernumerary spleens (HP:0009799)2.40396370
46Impaired proprioception (HP:0010831)2.37860985
47Embryonal renal neoplasm (HP:0011794)2.34102224
48Clubbing of toes (HP:0100760)2.31337903
49Sclerocornea (HP:0000647)2.31288443
50Fibular hypoplasia (HP:0003038)2.26138764
51Cystic liver disease (HP:0006706)2.26032230
52Tubular atrophy (HP:0000092)2.25868072
53Birth length less than 3rd percentile (HP:0003561)2.24721466
54Duodenal stenosis (HP:0100867)2.23793188
55Small intestinal stenosis (HP:0012848)2.23793188
56Volvulus (HP:0002580)2.20757118
57Aplasia/Hypoplasia of the tibia (HP:0005772)2.17526726
58Sloping forehead (HP:0000340)2.16264008
59Median cleft lip (HP:0000161)2.11390889
60Molar tooth sign on MRI (HP:0002419)2.11330266
61Abnormality of midbrain morphology (HP:0002418)2.11330266
62Abnormality of the renal cortex (HP:0011035)2.07638243
63Attenuation of retinal blood vessels (HP:0007843)2.07202044
64Bony spicule pigmentary retinopathy (HP:0007737)2.06758774
65Acute necrotizing encephalopathy (HP:0006965)2.06498476
66Acute encephalopathy (HP:0006846)2.05981812
67Medial flaring of the eyebrow (HP:0010747)2.05079867
68Anencephaly (HP:0002323)2.02890302
69Polydipsia (HP:0001959)2.01788257
70Abnormal drinking behavior (HP:0030082)2.01788257
71Bone marrow hypocellularity (HP:0005528)1.99970458
72Congenital stationary night blindness (HP:0007642)1.97278278
73Hypoplasia of the pons (HP:0012110)1.96348422
74Abnormality of the pons (HP:0007361)1.94685026
75Concave nail (HP:0001598)1.94361570
76Type II lissencephaly (HP:0007260)1.93944457
77Hypoplasia of the radius (HP:0002984)1.93785229
78Abnormal biliary tract physiology (HP:0012439)1.93640165
79Bile duct proliferation (HP:0001408)1.93640165
80Microglossia (HP:0000171)1.93528770
81Triphalangeal thumb (HP:0001199)1.93356117
82Intestinal atresia (HP:0011100)1.92736691
83Genital tract atresia (HP:0001827)1.91910174
84Increased hepatocellular lipid droplets (HP:0006565)1.91701638
85Increased CSF lactate (HP:0002490)1.90745680
86Abnormal lung lobation (HP:0002101)1.90743359
87Selective tooth agenesis (HP:0001592)1.88132836
88Aplastic anemia (HP:0001915)1.86652329
89Duplicated collecting system (HP:0000081)1.85787838
90Abnormality of macular pigmentation (HP:0008002)1.84810485
91Tubulointerstitial abnormality (HP:0001969)1.84624407
92Facial cleft (HP:0002006)1.83527141
93Congenital primary aphakia (HP:0007707)1.83124355
94Hypoplasia of the capital femoral epiphysis (HP:0003090)1.83104564
95Gastrointestinal atresia (HP:0002589)1.82213130
96Pancytopenia (HP:0001876)1.82090463
97Missing ribs (HP:0000921)1.81358181
98Mitochondrial inheritance (HP:0001427)1.80582093
99Bifid tongue (HP:0010297)1.79927454
100Gait imbalance (HP:0002141)1.79511500
101Poor coordination (HP:0002370)1.79428052
102Male pseudohermaphroditism (HP:0000037)1.78865093
103Vaginal atresia (HP:0000148)1.78242208
104Type I transferrin isoform profile (HP:0003642)1.78183692
105Cerebellar dysplasia (HP:0007033)1.77912720
106Occipital encephalocele (HP:0002085)1.77671995
107Congenital hepatic fibrosis (HP:0002612)1.77314021
1083-Methylglutaconic aciduria (HP:0003535)1.76885878
109Abnormality of the labia minora (HP:0012880)1.76771834
110Short tibia (HP:0005736)1.76398380
111Severe visual impairment (HP:0001141)1.76342355
112Lipid accumulation in hepatocytes (HP:0006561)1.74536117
113Myelodysplasia (HP:0002863)1.74200529
114Absent thumb (HP:0009777)1.74105362
115Oligodactyly (hands) (HP:0001180)1.73728357
116Progressive macrocephaly (HP:0004481)1.73360373
117Anophthalmia (HP:0000528)1.73241888
118Abnormal mitochondria in muscle tissue (HP:0008316)1.73048376
119Polyuria (HP:0000103)1.72930699
120Pulmonary fibrosis (HP:0002206)1.72852010
121True hermaphroditism (HP:0010459)1.72064988
122Abnormality of DNA repair (HP:0003254)1.71998984
123Renal Fanconi syndrome (HP:0001994)1.71985590
124Abnormality of the renal collecting system (HP:0004742)1.71027106
125Esophageal atresia (HP:0002032)1.70612162
126Pendular nystagmus (HP:0012043)1.70461779
127Renal dysplasia (HP:0000110)1.69593637
128Optic nerve hypoplasia (HP:0000609)1.69126641
129Bilateral microphthalmos (HP:0007633)1.68886327
130Colon cancer (HP:0003003)1.68343563
131Dyschromatopsia (HP:0007641)1.68125742
132Thrombocytosis (HP:0001894)1.67194886
133Glioma (HP:0009733)1.67164606
134Postaxial hand polydactyly (HP:0001162)1.66527117
135Dandy-Walker malformation (HP:0001305)1.66310800
136Furrowed tongue (HP:0000221)1.65516577
137Nephrogenic diabetes insipidus (HP:0009806)1.64971983
138Abnormality of the duodenum (HP:0002246)1.64649014
139Renal cortical cysts (HP:0000803)1.64391900
140Abnormal number of erythroid precursors (HP:0012131)1.63087427
141Absent frontal sinuses (HP:0002688)1.63056042
142Absent rod-and cone-mediated responses on ERG (HP:0007688)1.60508371
143Pancreatic fibrosis (HP:0100732)1.59475874
144Abnormality of the prostate (HP:0008775)1.57712592
145Preaxial hand polydactyly (HP:0001177)1.57293936
146Aplasia/Hypoplasia of the sacrum (HP:0008517)1.56776472
147Abnormality of the dental root (HP:0006486)1.55909731
148Taurodontia (HP:0000679)1.55909731
149Abnormality of permanent molar morphology (HP:0011071)1.55909731
150Chronic sinusitis (HP:0011109)1.55892821
151Aplasia/Hypoplasia of the fibula (HP:0006492)1.55519602
152Prostate neoplasm (HP:0100787)1.55284719
153Abnormality of the carotid arteries (HP:0005344)1.54964078
154Abnormality of molar (HP:0011077)1.54332980
155Abnormality of molar morphology (HP:0011070)1.54332980
156Abnormality of renal resorption (HP:0011038)1.53850813
157Aplasia/Hypoplasia of the tongue (HP:0010295)1.53566730
158Stage 5 chronic kidney disease (HP:0003774)1.53201713
159Pallor (HP:0000980)1.50690586
160Abnormal glycosylation (HP:0012345)1.49494162
161Abnormal protein N-linked glycosylation (HP:0012347)1.49494162

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK35.34522878
2PDK45.34522878
3FRK3.93635841
4PDK23.41360522
5CDC73.21672525
6CLK12.70767046
7WEE12.51419547
8TLK12.45215489
9MAP4K22.21971216
10WNK32.21508166
11PLK42.16362261
12NEK22.13617925
13BUB12.12857957
14VRK11.99713737
15STK161.95464998
16SRPK11.95095397
17MAP3K41.89571892
18TTK1.81091696
19EIF2AK11.77204921
20INSRR1.76394953
21STK391.71771860
22ZAK1.65901992
23IRAK31.65806289
24IRAK41.60292286
25PNCK1.58236434
26BMPR1B1.56368652
27IRAK11.53522229
28MKNK21.48194781
29BRSK21.46571606
30WNK41.43917235
31TRIM281.43075860
32NME21.40074693
33PLK11.39754528
34CCNB11.38872673
35TESK11.37812473
36STK31.35623331
37ATR1.32462978
38NUAK11.31500365
39GRK11.30530231
40NLK1.29494547
41TXK1.27990917
42PLK21.27188535
43EIF2AK21.27028727
44MKNK11.21164416
45TEC1.18350963
46CAMK1G1.13161561
47DYRK31.12919622
48AKT31.12595772
49STK241.09014423
50PBK1.08373748
51PTK2B1.07064645
52AURKB1.03604006
53MAPK131.02330491
54PASK1.02136108
55CHEK21.01103865
56MUSK1.00921970
57LATS10.97463775
58TGFBR10.94305583
59BCR0.93926940
60CASK0.91326131
61TSSK60.91282117
62MAP3K140.90673421
63OXSR10.89890357
64BCKDK0.89375791
65CSNK1G10.86952664
66MAP2K70.83084546
67YES10.79708877
68CDK70.78961205
69MAPK150.78306009
70NTRK30.78146281
71EIF2AK30.77623507
72CHEK10.77042879
73ERBB30.75564772
74FGFR20.75333835
75NME10.75313899
76ATM0.74477071
77CDK30.72629948
78CSNK1G30.72587140
79STK40.72478699
80STK38L0.70776413
81CSNK1G20.69629314
82DYRK20.68411072
83BRSK10.67793934
84MAP3K20.67453694
85PIM10.67393819
86NEK10.66699101
87CSNK1A1L0.66667985
88NEK90.65269050
89RPS6KA50.64864575
90IRAK20.64106184
91BTK0.62482882
92WNK10.62277141
93MAP4K10.62176943
94PRKCG0.60001314
95STK380.59375502
96AURKA0.58380943
97KIT0.57887261
98BRAF0.57539583
99PLK30.57284987
100BMPR20.57121663
101PAK30.55761857
102BRD40.55408375
103PRKD30.55206568
104PRKCE0.53974099
105FLT30.53224484
106ACVR1B0.51612687
107TAF10.51469838
108CSNK2A10.50747717
109TNK20.48378790
110IKBKE0.48230330
111ADRBK10.47810546
112CAMK1D0.47215340
113CDK40.46669833
114CDK90.46218979
115IKBKB0.45968197
116TNIK0.45882319
117VRK20.45408756
118NEK60.45094713
119CSNK1E0.43952869
120CAMK10.41259389
121STK100.41144068
122PIM20.39424017
123ILK0.35988852
124MINK10.35006612
125ADRBK20.34423100
126LYN0.33887834
127RPS6KA40.33603901
128MARK10.33347295
129CDK10.33086028
130FGFR10.32419823
131PRKG20.32395399
132MAPKAPK50.32313605
133DYRK1B0.31925824
134EPHA30.31921087
135CSNK1D0.31514642
136CSNK2A20.30859253
137PRKACB0.30433709
138PINK10.29034641
139CDK80.27956696
140CDK20.26053168
141PRKD20.25909546
142PRPF4B0.20012125
143LCK0.19892447
144MST40.19693155
145MARK30.19298455

Predicted pathways (KEGG)

RankGene SetZ-score
1Fanconi anemia pathway_Homo sapiens_hsa034604.14148112
2Homologous recombination_Homo sapiens_hsa034403.81832919
3DNA replication_Homo sapiens_hsa030303.49738006
4Basal transcription factors_Homo sapiens_hsa030223.14299053
5Ribosome_Homo sapiens_hsa030102.96259296
6Mismatch repair_Homo sapiens_hsa034302.92247900
7Vitamin B6 metabolism_Homo sapiens_hsa007502.56492038
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.48658908
9Non-homologous end-joining_Homo sapiens_hsa034502.46453501
10Base excision repair_Homo sapiens_hsa034102.43194840
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.39352774
12Spliceosome_Homo sapiens_hsa030402.34615631
13RNA polymerase_Homo sapiens_hsa030202.24029528
14Nucleotide excision repair_Homo sapiens_hsa034202.22706615
15Pyrimidine metabolism_Homo sapiens_hsa002402.21345459
16Cell cycle_Homo sapiens_hsa041102.12202908
17RNA transport_Homo sapiens_hsa030132.04712548
18RNA degradation_Homo sapiens_hsa030181.98821218
19Proteasome_Homo sapiens_hsa030501.98550617
20Huntingtons disease_Homo sapiens_hsa050161.79361470
21Butanoate metabolism_Homo sapiens_hsa006501.77866192
22Nitrogen metabolism_Homo sapiens_hsa009101.69654903
23Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.68893508
24Phototransduction_Homo sapiens_hsa047441.65487096
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.64518737
26mRNA surveillance pathway_Homo sapiens_hsa030151.63127573
27Purine metabolism_Homo sapiens_hsa002301.51880007
28Protein export_Homo sapiens_hsa030601.44672305
29Systemic lupus erythematosus_Homo sapiens_hsa053221.36590204
30Steroid biosynthesis_Homo sapiens_hsa001001.34741205
31Primary immunodeficiency_Homo sapiens_hsa053401.33238793
32Olfactory transduction_Homo sapiens_hsa047401.30116745
33Antigen processing and presentation_Homo sapiens_hsa046121.28879654
34Nicotine addiction_Homo sapiens_hsa050331.28485788
35Linoleic acid metabolism_Homo sapiens_hsa005911.27886008
36Arachidonic acid metabolism_Homo sapiens_hsa005901.25129303
37p53 signaling pathway_Homo sapiens_hsa041151.23744753
38Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.21024145
39Intestinal immune network for IgA production_Homo sapiens_hsa046721.20223591
40Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.12756084
41Primary bile acid biosynthesis_Homo sapiens_hsa001201.12223474
42Herpes simplex infection_Homo sapiens_hsa051681.10177776
43Sulfur relay system_Homo sapiens_hsa041221.09755139
44alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.09350364
45Selenocompound metabolism_Homo sapiens_hsa004501.08454241
46Oocyte meiosis_Homo sapiens_hsa041141.07513877
47Tryptophan metabolism_Homo sapiens_hsa003801.05823040
48Glycosaminoglycan degradation_Homo sapiens_hsa005311.05262516
49Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.01657161
50Cysteine and methionine metabolism_Homo sapiens_hsa002701.01004231
51Pentose phosphate pathway_Homo sapiens_hsa000301.00734912
52Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.99948751
53One carbon pool by folate_Homo sapiens_hsa006700.99698846
54Taste transduction_Homo sapiens_hsa047420.98244459
55Ether lipid metabolism_Homo sapiens_hsa005650.98071769
56Lysine degradation_Homo sapiens_hsa003100.97872858
57Measles_Homo sapiens_hsa051620.94305241
58Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.94224232
59Fatty acid biosynthesis_Homo sapiens_hsa000610.89535787
60Epstein-Barr virus infection_Homo sapiens_hsa051690.88329337
61Graft-versus-host disease_Homo sapiens_hsa053320.86457194
62Hematopoietic cell lineage_Homo sapiens_hsa046400.86154479
63Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.84137115
64NF-kappa B signaling pathway_Homo sapiens_hsa040640.83884194
65Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.82308635
66Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.81971374
67Peroxisome_Homo sapiens_hsa041460.80617436
68Sphingolipid metabolism_Homo sapiens_hsa006000.78883455
69Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.77666199
70Chemical carcinogenesis_Homo sapiens_hsa052040.75418074
71Dorso-ventral axis formation_Homo sapiens_hsa043200.75406364
72Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.72985721
73Cardiac muscle contraction_Homo sapiens_hsa042600.72905729
74Oxidative phosphorylation_Homo sapiens_hsa001900.71880963
75Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.71800017
76Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.71421156
77Arginine biosynthesis_Homo sapiens_hsa002200.70814597
78NOD-like receptor signaling pathway_Homo sapiens_hsa046210.70445460
79Asthma_Homo sapiens_hsa053100.70359442
80Fatty acid elongation_Homo sapiens_hsa000620.69476591
81Caffeine metabolism_Homo sapiens_hsa002320.68932269
82Fatty acid metabolism_Homo sapiens_hsa012120.67749958
83TGF-beta signaling pathway_Homo sapiens_hsa043500.67622533
84Hedgehog signaling pathway_Homo sapiens_hsa043400.66657102
85Allograft rejection_Homo sapiens_hsa053300.65786258
86Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.65199767
87Autoimmune thyroid disease_Homo sapiens_hsa053200.65110168
88Parkinsons disease_Homo sapiens_hsa050120.63361758
89Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.62489932
90Basal cell carcinoma_Homo sapiens_hsa052170.57820033
91Influenza A_Homo sapiens_hsa051640.57666292
92Viral carcinogenesis_Homo sapiens_hsa052030.56474718
93beta-Alanine metabolism_Homo sapiens_hsa004100.56289731
94Arginine and proline metabolism_Homo sapiens_hsa003300.56279981
95Pyruvate metabolism_Homo sapiens_hsa006200.55851240
96Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.55411092
97Regulation of autophagy_Homo sapiens_hsa041400.55292239
98HTLV-I infection_Homo sapiens_hsa051660.54783859
99Fat digestion and absorption_Homo sapiens_hsa049750.53284297
100Folate biosynthesis_Homo sapiens_hsa007900.52778018
101Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.52382859
102Transcriptional misregulation in cancer_Homo sapiens_hsa052020.51529475
103Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.51189671
104Drug metabolism - other enzymes_Homo sapiens_hsa009830.49726626
105SNARE interactions in vesicular transport_Homo sapiens_hsa041300.49077898
106Legionellosis_Homo sapiens_hsa051340.48370916
107Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.47962043
108Fatty acid degradation_Homo sapiens_hsa000710.47907336
109Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.47783063
110Glycerolipid metabolism_Homo sapiens_hsa005610.47590786
111N-Glycan biosynthesis_Homo sapiens_hsa005100.46304908
112Vitamin digestion and absorption_Homo sapiens_hsa049770.45492130
113Hippo signaling pathway_Homo sapiens_hsa043900.44913207
114Sulfur metabolism_Homo sapiens_hsa009200.44793567
115Pentose and glucuronate interconversions_Homo sapiens_hsa000400.44600228
116Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.44581791
117Glutathione metabolism_Homo sapiens_hsa004800.44285345
118Alzheimers disease_Homo sapiens_hsa050100.43335070
119Retinol metabolism_Homo sapiens_hsa008300.40524875
120Jak-STAT signaling pathway_Homo sapiens_hsa046300.39210078
121Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.38297690
122Other glycan degradation_Homo sapiens_hsa005110.37781165
123Alcoholism_Homo sapiens_hsa050340.37571369
124Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.36792049
125Malaria_Homo sapiens_hsa051440.36345518
126Metabolic pathways_Homo sapiens_hsa011000.35782305
127RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.30507879
128Maturity onset diabetes of the young_Homo sapiens_hsa049500.30039030
129Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.29636527
130Propanoate metabolism_Homo sapiens_hsa006400.29352263
131T cell receptor signaling pathway_Homo sapiens_hsa046600.29319100
132Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.26896593
133Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.26662620
134Leishmaniasis_Homo sapiens_hsa051400.26639317
135Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.25301150
136Histidine metabolism_Homo sapiens_hsa003400.25165640
137Hepatitis B_Homo sapiens_hsa051610.24958496
138Glucagon signaling pathway_Homo sapiens_hsa049220.24887868
139Salmonella infection_Homo sapiens_hsa051320.23862496
140B cell receptor signaling pathway_Homo sapiens_hsa046620.22777878
141ABC transporters_Homo sapiens_hsa020100.21512856
142Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.20359339
143Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.19927154
144Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.19835055
145Steroid hormone biosynthesis_Homo sapiens_hsa001400.18095839
146Prostate cancer_Homo sapiens_hsa052150.17271485

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