DNAH17

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Dyneins are microtubule-associated motor protein complexes composed of several heavy, light, and intermediate chains. DNAH17 is a heavy chain associated with axonemal dynein (Milisav and Affara, 1998 [PubMed 9545504]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1acrosome assembly (GO:0001675)9.64538794
2plasma membrane fusion (GO:0045026)9.63226994
3motile cilium assembly (GO:0044458)9.62428461
4acrosome reaction (GO:0007340)9.58537790
5male meiosis (GO:0007140)9.53536008
6binding of sperm to zona pellucida (GO:0007339)9.52119467
7epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)9.38669397
8cell-cell recognition (GO:0009988)9.35231878
9cilium movement (GO:0003341)9.32654256
10spermatid development (GO:0007286)8.82500391
11reproduction (GO:0000003)8.56360321
12synaptonemal complex organization (GO:0070193)8.42405784
13regulation of cilium movement (GO:0003352)8.11107556
14synaptonemal complex assembly (GO:0007130)7.94235775
15cell wall macromolecule catabolic process (GO:0016998)7.48715015
16cell wall macromolecule metabolic process (GO:0044036)7.48715015
17single fertilization (GO:0007338)7.29691119
18DNA methylation involved in gamete generation (GO:0043046)7.22954494
19sperm capacitation (GO:0048240)6.90875027
20male meiosis I (GO:0007141)6.77449154
21fertilization (GO:0009566)6.30281393
22ventricular system development (GO:0021591)5.96765587
23chromosome organization involved in meiosis (GO:0070192)5.72973689
24negative regulation of inclusion body assembly (GO:0090084)5.66025105
25meiotic nuclear division (GO:0007126)5.58101922
26spermatogenesis (GO:0007283)5.48449184
27meiosis I (GO:0007127)5.47032888
28male gamete generation (GO:0048232)5.46592627
29meiotic cell cycle (GO:0051321)5.35429240
30germ cell development (GO:0007281)5.24983107
31cellular process involved in reproduction in multicellular organism (GO:0022412)5.15442384
32seminiferous tubule development (GO:0072520)5.04719708
33protein localization to cilium (GO:0061512)5.04180855
34gamete generation (GO:0007276)5.02117242
35gene silencing by RNA (GO:0031047)4.68235627
36microtubule depolymerization (GO:0007019)4.67024301
37regulation of microtubule-based movement (GO:0060632)4.64890183
38organic cation transport (GO:0015695)4.58693649
39left/right pattern formation (GO:0060972)4.49965800
40cell recognition (GO:0008037)4.43071624
41regulation of inclusion body assembly (GO:0090083)4.40785152
42antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.40634743
43monoubiquitinated protein deubiquitination (GO:0035520)4.39178591
44macrophage activation involved in immune response (GO:0002281)4.36852110
45negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.32973571
46negative regulation of cell killing (GO:0031342)4.32973571
47cellular response to ATP (GO:0071318)4.29423716
48intraciliary transport (GO:0042073)4.24458089
49genitalia morphogenesis (GO:0035112)4.22593087
50microtubule severing (GO:0051013)4.22197944
51response to peptidoglycan (GO:0032494)4.20658524
52calcium ion-dependent exocytosis (GO:0017156)4.14074498
53regulation of centriole replication (GO:0046599)4.02086087
54multicellular organismal reproductive process (GO:0048609)3.94353001
55axoneme assembly (GO:0035082)3.89627542
56negative regulation of organelle assembly (GO:1902116)3.87891699
57modulation by symbiont of host immune response (GO:0052553)3.83849972
58positive regulation by symbiont of host defense response (GO:0052509)3.83849972
59modulation by symbiont of host defense response (GO:0052031)3.83849972
60modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.83849972
61modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.83849972
62positive regulation by organism of defense response of other organism involved in symbiotic interact3.83849972
63regulation of interferon-beta biosynthetic process (GO:0045357)3.83361074
64regulation of meiosis I (GO:0060631)3.80413570
65nuclear pore complex assembly (GO:0051292)3.80065924
66protein polyglutamylation (GO:0018095)3.77304789
67regulation of protein polyubiquitination (GO:1902914)3.69799914
68* microtubule-based movement (GO:0007018)3.62337437
69meiotic cell cycle process (GO:1903046)3.59994631
70T-helper 1 type immune response (GO:0042088)3.53749546
71centriole replication (GO:0007099)3.51583090
72purinergic nucleotide receptor signaling pathway (GO:0035590)3.48724377
73synapsis (GO:0007129)3.48118368
74microglial cell activation (GO:0001774)3.45753137
75negative regulation of interleukin-12 production (GO:0032695)3.41313040
76detection of molecule of bacterial origin (GO:0032490)3.40601584
77positive regulation of gamma-delta T cell activation (GO:0046645)3.39351659
78centriole assembly (GO:0098534)3.39160844
79myeloid cell activation involved in immune response (GO:0002275)3.38528913
80detection of light stimulus involved in sensory perception (GO:0050962)3.35963385
81detection of light stimulus involved in visual perception (GO:0050908)3.35963385
82cilium organization (GO:0044782)3.35312306
83lactate metabolic process (GO:0006089)3.33493815
84meiotic chromosome segregation (GO:0045132)3.31533104
85response to interleukin-15 (GO:0070672)3.31356059
86RNA destabilization (GO:0050779)3.29185531
87regulation of B cell receptor signaling pathway (GO:0050855)3.24968890
88carnitine transmembrane transport (GO:1902603)3.24293757
89positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.23223602
90multicellular organismal development (GO:0007275)3.21987111
91phosphatidylethanolamine biosynthetic process (GO:0006646)3.21821040
92amino-acid betaine transport (GO:0015838)3.20883637
93carnitine transport (GO:0015879)3.20883637
94cilium assembly (GO:0042384)3.19253523
95negative regulation of DNA repair (GO:0045738)3.19135787
96negative regulation of interleukin-8 production (GO:0032717)3.18928631
97cellular response to interleukin-15 (GO:0071350)3.17328031
98positive regulation of heat generation (GO:0031652)3.13527447
99chaperone-mediated protein complex assembly (GO:0051131)3.12587794
100defense response to protozoan (GO:0042832)3.09223431
101mitotic cell cycle arrest (GO:0071850)3.08651762
102negative regulation of cAMP-mediated signaling (GO:0043951)3.07722984
103positive regulation of T cell mediated cytotoxicity (GO:0001916)3.07563072
104regulation of T cell mediated cytotoxicity (GO:0001914)3.04722201
105neutrophil mediated immunity (GO:0002446)3.04612559
106mitotic sister chromatid cohesion (GO:0007064)3.04136061
107gene silencing (GO:0016458)3.03240622
108germinal center formation (GO:0002467)3.03201865
109regulation of mast cell activation (GO:0033003)3.02992473
110macrophage activation (GO:0042116)3.02372245
111regulation of T-helper 2 cell differentiation (GO:0045628)3.01039475
112negative regulation of lymphocyte mediated immunity (GO:0002707)3.00100695
113regulation of spindle checkpoint (GO:0090231)3.00073288
114pore complex assembly (GO:0046931)3.00022497
115mast cell activation involved in immune response (GO:0002279)2.99997959
116mast cell degranulation (GO:0043303)2.99997959
117leukocyte degranulation (GO:0043299)2.99616455
118phosphatidylethanolamine metabolic process (GO:0046337)2.98274404
119cellular extravasation (GO:0045123)2.98197613
120cellular component assembly involved in morphogenesis (GO:0010927)2.95390262
121nuclear pore organization (GO:0006999)2.95084042
122alditol metabolic process (GO:0019400)2.94841904
123response to protozoan (GO:0001562)2.92548856
124detection of other organism (GO:0098543)2.91068545
125cilium morphogenesis (GO:0060271)2.90579064
126negative regulation of Rho protein signal transduction (GO:0035024)2.90119258
127G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.90072147
128immunoglobulin mediated immune response (GO:0016064)2.89945529
129response to type I interferon (GO:0034340)2.88980027
130regulation of cytokine production involved in inflammatory response (GO:1900015)2.88496879
131DNA alkylation (GO:0006305)2.86702667
132DNA methylation (GO:0006306)2.86702667
133detection of external biotic stimulus (GO:0098581)2.86409490
134positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.85255949
135mannose metabolic process (GO:0006013)2.85014247
136negative regulation of innate immune response (GO:0045824)2.84733526
137cellular response to type I interferon (GO:0071357)2.83371587
138type I interferon signaling pathway (GO:0060337)2.83371587
139regulation of gamma-delta T cell activation (GO:0046643)2.83332724
140neutrophil activation (GO:0042119)2.82852518
141regulation of mast cell degranulation (GO:0043304)2.82563270
142translesion synthesis (GO:0019985)2.82373811
143mast cell activation (GO:0045576)2.82046497
144regulation of interferon-beta production (GO:0032648)2.81833520
145adenosine receptor signaling pathway (GO:0001973)2.80589049
146purinergic receptor signaling pathway (GO:0035587)2.79778248
147negative regulation of toll-like receptor signaling pathway (GO:0034122)2.79168525
148spermatid nucleus differentiation (GO:0007289)2.78779990
149peptidyl-glutamic acid modification (GO:0018200)2.78615209
150regulation of histone H3-K9 methylation (GO:0051570)2.78288040
151rRNA methylation (GO:0031167)2.77383534
152protein refolding (GO:0042026)2.77173829
153regulation of interferon-alpha production (GO:0032647)2.77062618
154granulocyte activation (GO:0036230)2.76873490
155regulation of mast cell activation involved in immune response (GO:0033006)2.76866072
156positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.76490292
157protein import into peroxisome matrix (GO:0016558)2.74988642
158response to ATP (GO:0033198)2.73653262
159nucleotide transmembrane transport (GO:1901679)2.73132394
160positive regulation of interferon-alpha production (GO:0032727)2.72802043
161response to muramyl dipeptide (GO:0032495)2.72085669
162detection of bacterium (GO:0016045)2.71533253
163polyol catabolic process (GO:0046174)2.69181611
164negative regulation of protein oligomerization (GO:0032460)2.68838497
165neutrophil activation involved in immune response (GO:0002283)2.68585846
166DNA deamination (GO:0045006)2.67814842
167interferon-gamma production (GO:0032609)2.66830980
168regulation of memory T cell differentiation (GO:0043380)2.66513864
169antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.66307306
170positive regulation of interferon-beta production (GO:0032728)2.65896066
171regulation of toll-like receptor signaling pathway (GO:0034121)2.63819230
172left/right axis specification (GO:0070986)2.63319112
173glycerol metabolic process (GO:0006071)2.62981682
174nucleus organization (GO:0006997)2.62943566
175transepithelial transport (GO:0070633)2.62889424
176nucleoside diphosphate phosphorylation (GO:0006165)2.62575396
177regulation of T-helper cell differentiation (GO:0045622)2.62256882
178positive regulation of defense response to virus by host (GO:0002230)2.61765113
179positive regulation of mast cell activation (GO:0033005)2.61546288
180positive regulation of toll-like receptor signaling pathway (GO:0034123)2.60536296
181regulation of interleukin-6 biosynthetic process (GO:0045408)2.60191046
182regulation of chromatin binding (GO:0035561)2.59823568
183sister chromatid cohesion (GO:0007062)2.59423977
184response to host immune response (GO:0052572)2.59398880
185response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.59398880
186lens fiber cell differentiation (GO:0070306)2.59371062
187glycerol ether metabolic process (GO:0006662)2.47204422
188negative regulation of skeletal muscle tissue development (GO:0048642)2.46964212
189* cilium or flagellum-dependent cell motility (GO:0001539)17.5032241
190fusion of sperm to egg plasma membrane (GO:0007342)12.7064682
191piRNA metabolic process (GO:0034587)12.0338707
192axonemal dynein complex assembly (GO:0070286)11.6055860
193sperm motility (GO:0030317)11.5275216
194multicellular organism reproduction (GO:0032504)10.7388990
195sperm-egg recognition (GO:0035036)10.4312180
196epithelial cilium movement (GO:0003351)10.2062690

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.08664501
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.64690655
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.89224101
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.79953020
5VDR_21846776_ChIP-Seq_THP-1_Human3.11121268
6IRF8_21731497_ChIP-ChIP_J774_Mouse2.78580478
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.52626051
8FLI1_27457419_Chip-Seq_LIVER_Mouse2.40757310
9NOTCH1_21737748_ChIP-Seq_TLL_Human2.40414679
10P68_20966046_ChIP-Seq_HELA_Human2.40365629
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.33901177
12* BCL6_27268052_Chip-Seq_Bcells_Human2.33265352
13MAF_26560356_Chip-Seq_TH2_Human2.28838375
14E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.28368962
15* BCOR_27268052_Chip-Seq_Bcells_Human2.26029885
16VDR_24763502_ChIP-Seq_THP-1_Human2.25538606
17ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.21702406
18CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.19944589
19PCGF2_27294783_Chip-Seq_ESCs_Mouse2.19539467
20E2F1_20622854_ChIP-Seq_HELA_Human2.17698750
21BP1_19119308_ChIP-ChIP_Hs578T_Human2.09727806
22CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.07528440
23MAF_26560356_Chip-Seq_TH1_Human2.07155007
24SCL_19346495_ChIP-Seq_HPC-7_Human2.06485514
25EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.05909437
26SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.05718733
27MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.05480343
28PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.05248353
29CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.05180197
30VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.03407520
31IKZF1_21737484_ChIP-ChIP_HCT116_Human2.00287972
32MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse11.6252567
33ZNF274_21170338_ChIP-Seq_K562_Hela1.90543549
34ELK4_26923725_Chip-Seq_MESODERM_Mouse1.88293410
35EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.88247631
36ELF1_20517297_ChIP-Seq_JURKAT_Human1.85687588
37UTX_26944678_Chip-Seq_JUKART_Human1.82135528
38DROSHA_22980978_ChIP-Seq_HELA_Human1.81790908
39IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.80235794
40* PHF8_20622854_ChIP-Seq_HELA_Human1.79907650
41IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.79802911
42* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.75931643
43GATA1_26923725_Chip-Seq_HPCs_Mouse1.75882153
44EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.75713154
45PCGF2_27294783_Chip-Seq_NPCs_Mouse1.75143008
46LXR_22292898_ChIP-Seq_THP-1_Human1.72632870
47RUNX_20019798_ChIP-Seq_JUKART_Human1.71464656
48RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.70886038
49VDR_22108803_ChIP-Seq_LS180_Human1.70369490
50KDM2B_26808549_Chip-Seq_SUP-B15_Human1.67973725
51NFE2_27457419_Chip-Seq_LIVER_Mouse1.67070925
52TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.66481784
53ERA_21632823_ChIP-Seq_H3396_Human1.64186491
54* SMC4_20622854_ChIP-Seq_HELA_Human1.63700140
55MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.57656141
56SUZ12_27294783_Chip-Seq_NPCs_Mouse1.57137281
57RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.55731812
58IRF8_27001747_Chip-Seq_BMDM_Mouse1.55674098
59SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.54028657
60SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.53133530
61STAT1_17558387_ChIP-Seq_HELA_Human1.50364678
62CTCF_20526341_ChIP-Seq_ESCs_Human1.49959507
63TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.49449898
64P300_27268052_Chip-Seq_Bcells_Human1.49217051
65* NANOG_20526341_ChIP-Seq_ESCs_Human1.48996167
66TAF2_19829295_ChIP-Seq_ESCs_Human1.48423375
67* YY1_22570637_ChIP-Seq_MALME-3M_Human1.47167715
68OCT4_20526341_ChIP-Seq_ESCs_Human1.46721279
69IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.46275871
70CBP_20019798_ChIP-Seq_JUKART_Human1.46275871
71KAP1_22055183_ChIP-Seq_ESCs_Mouse1.45055115
72STAT4_19710469_ChIP-ChIP_TH1__Mouse1.43997216
73RAC3_21632823_ChIP-Seq_H3396_Human1.38972089
74KDM2B_26808549_Chip-Seq_DND41_Human1.38193978
75MYC_22102868_ChIP-Seq_BL_Human1.38060673
76* OCT4_19829295_ChIP-Seq_ESCs_Human1.37694459
77TAL1_26923725_Chip-Seq_HPCs_Mouse1.37480609
78BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human1.36775565
79GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36305787
80TCF7_22412390_ChIP-Seq_EML_Mouse1.35365432
81MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.34203891
82MYB_26560356_Chip-Seq_TH1_Human1.33363664
83TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.32412992
84FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.31880217
85GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.31515197
86SPI1_23127762_ChIP-Seq_K562_Human1.31311513
87RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.30926273
88* WDR5_24793694_ChIP-Seq_LNCAP_Human1.30329952
89KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.30211130
90RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.29619947
91MYB_26560356_Chip-Seq_TH2_Human1.28210360
92CTCF_27219007_Chip-Seq_ERYTHROID_Human1.28112111
93MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.27300928
94GATA3_27048872_Chip-Seq_THYMUS_Human1.26621954
95KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.25325133
96SA1_27219007_Chip-Seq_Bcells_Human1.25187909
97KDM2B_26808549_Chip-Seq_REH_Human1.24697739
98SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24035026
99MYC_19829295_ChIP-Seq_ESCs_Human1.23643620
100EZH2_27294783_Chip-Seq_NPCs_Mouse1.21689361
101SPI1_23547873_ChIP-Seq_NB4_Human1.20188500
102CRX_20693478_ChIP-Seq_RETINA_Mouse1.19954865
103PKCTHETA_26484144_Chip-Seq_BREAST_Human1.19892581
104CTCF_27219007_Chip-Seq_Bcells_Human1.18749440
105TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18448630
106POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.18448630
107MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.18174270
108OCT4_18555785_Chip-Seq_ESCs_Mouse1.17821661
109CTCF_21964334_ChIP-Seq_BJAB-B_Human1.17693684
110GATA3_26560356_Chip-Seq_TH2_Human1.17326206
111* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.16554680
112RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16470299
113SA1_27219007_Chip-Seq_ERYTHROID_Human1.15113683
114MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.15013015
115SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.14491636
116NANOG_18555785_Chip-Seq_ESCs_Mouse1.14482756
117PU.1_20513432_ChIP-Seq_Bcells_Mouse1.14262047
118RARB_24833708_ChIP-Seq_LIVER_Mouse1.14116000
119EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.12759072
120CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.11746506
121SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11743704
122CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10855635
123RUNX1_22412390_ChIP-Seq_EML_Mouse1.10771567
124OCT4_21477851_ChIP-Seq_ESCs_Mouse1.10634068
125PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.10222793
126SOX2_22085726_ChIP-Seq_NPCs_Mouse1.10083153
127ZFP57_27257070_Chip-Seq_ESCs_Mouse1.09930145
128P53_22387025_ChIP-Seq_ESCs_Mouse1.09109262
129REST_21632747_ChIP-Seq_MESCs_Mouse1.08901529
130PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.07942306
131RARA_24833708_ChIP-Seq_LIVER_Mouse1.07901779
132NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.07894005
133STAT3_18555785_Chip-Seq_ESCs_Mouse1.07514635
134GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.07345413
135TP63_22573176_ChIP-Seq_HFKS_Human1.07344247
136TCF4_23295773_ChIP-Seq_U87_Human1.07195077
137CTCF_21964334_Chip-Seq_Bcells_Human1.06642864
138RXRA_24833708_ChIP-Seq_LIVER_Mouse1.06473376
139P300_18555785_Chip-Seq_ESCs_Mouse1.06320777
140SPI1_20517297_ChIP-Seq_HL60_Human1.06311869
141EGR1_23403033_ChIP-Seq_LIVER_Mouse1.06246802
142MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.05854546
143FLI1_21867929_ChIP-Seq_TH2_Mouse1.05464752
144CBX2_27304074_Chip-Seq_ESCs_Mouse1.05280355
145EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.05067695
146KLF4_18555785_Chip-Seq_ESCs_Mouse1.05024371
147* TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.04742354
148CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.04107761
149GATA3_21867929_ChIP-Seq_CD8_Mouse1.04092717
150LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.03588351
151RUNX1_26923725_Chip-Seq_HPCs_Mouse1.03371123
152ESRRB_18555785_Chip-Seq_ESCs_Mouse1.02945636
153PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.02901393
154GF1_26923725_Chip-Seq_HPCs_Mouse1.02707246
155VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.02407434
156P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.01724066
157RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.01593094
158STAT6_21828071_ChIP-Seq_BEAS2B_Human1.01154007
159PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01060301
160CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.00869247
161GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00839149
162CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.00502728
163GATA3_21878914_ChIP-Seq_MCF-7_Human1.00366745
164ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.99645170
165GATA3_21867929_ChIP-Seq_TH1_Mouse0.98592876
166CMYC_18555785_Chip-Seq_ESCs_Mouse0.96996651
167SUZ12_18555785_Chip-Seq_ESCs_Mouse0.96482355
168CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95412320
169FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95273215
170PU1_27457419_Chip-Seq_LIVER_Mouse0.94627494
171BCAT_22108803_ChIP-Seq_LS180_Human0.93046505
172TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92714586
173SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.92566859
174RUNX1_27457419_Chip-Seq_LIVER_Mouse0.91927272
175ER_23166858_ChIP-Seq_MCF-7_Human0.90397381
176RAD21_21589869_ChIP-Seq_MESCs_Mouse0.89971579
177RNF2_27304074_Chip-Seq_NSC_Mouse0.89189541
178NFYB_21822215_ChIP-Seq_K562_Human0.89099702
179ZFX_18555785_Chip-Seq_ESCs_Mouse0.88592010
180GATA3_26560356_Chip-Seq_TH1_Human0.88314889
181P53_21459846_ChIP-Seq_SAOS-2_Human0.87174586
182RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.86766183
183E2F1_18555785_Chip-Seq_ESCs_Mouse0.86650912
184SMAD4_21741376_ChIP-Seq_EPCs_Human0.86339288
185SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.86061661
186CTCF_18555785_Chip-Seq_ESCs_Mouse0.85517124
187FOXA1_25329375_ChIP-Seq_VCAP_Human0.84723238
188FOXA1_27270436_Chip-Seq_PROSTATE_Human0.84723238
189PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.84645205
190EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.84388990
191TBL1_22424771_ChIP-Seq_293T_Human0.84235058
192EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.83147847
193TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.82658113
194CTBP2_25329375_ChIP-Seq_LNCAP_Human0.82286242

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.83698263
2MP0008877_abnormal_DNA_methylation5.58681855
3MP0001929_abnormal_gametogenesis5.38744576
4MP0002653_abnormal_ependyma_morphology4.19815618
5MP0002210_abnormal_sex_determination3.97659747
6MP0006082_CNS_inflammation3.68746006
7MP0003303_peritoneal_inflammation3.60786465
8MP0003724_increased_susceptibility_to3.47528035
9MP0001145_abnormal_male_reproductive3.27402544
10MP0002161_abnormal_fertility/fecundity3.15473726
11MP0000653_abnormal_sex_gland2.83753169
12MP0005623_abnormal_meninges_morphology2.82709511
13MP0003436_decreased_susceptibility_to2.76886850
14MP0008057_abnormal_DNA_replication2.61073473
15MP0005423_abnormal_somatic_nervous2.43256014
16MP0005671_abnormal_response_to2.36707618
17MP0002254_reproductive_system_inflammat2.35243202
18MP0001800_abnormal_humoral_immune2.25436204
19MP0005387_immune_system_phenotype2.11246650
20MP0001790_abnormal_immune_system2.11246650
21MP0002419_abnormal_innate_immunity2.09933643
22MP0005000_abnormal_immune_tolerance2.08566748
23MP0009785_altered_susceptibility_to2.08482027
24MP0002160_abnormal_reproductive_system2.01277888
25MP0005410_abnormal_fertilization14.3233498
26MP0005025_abnormal_response_to1.99897007
27MP0005171_absent_coat_pigmentation1.99388231
28MP0001968_abnormal_touch/_nociception1.96706857
29MP0003690_abnormal_glial_cell1.96029836
30MP0005167_abnormal_blood-brain_barrier1.94260616
31MP0000569_abnormal_digit_pigmentation1.90582539
32MP0003136_yellow_coat_color1.84143834
33MP0002452_abnormal_antigen_presenting1.82880642
34MP0005310_abnormal_salivary_gland1.80728327
35MP0002420_abnormal_adaptive_immunity1.74463799
36MP0010094_abnormal_chromosome_stability1.72569831
37MP0001819_abnormal_immune_cell1.71583353
38MP0008058_abnormal_DNA_repair1.69343216
39MP0002148_abnormal_hypersensitivity_rea1.67904356
40MP0002132_abnormal_respiratory_system1.66344301
41MP0002282_abnormal_trachea_morphology1.59472312
42MP0001873_stomach_inflammation1.53780853
43MP0009764_decreased_sensitivity_to1.51683246
44MP0004381_abnormal_hair_follicle1.50056346
45MP0005670_abnormal_white_adipose1.45599677
46MP0001348_abnormal_lacrimal_gland1.41636343
47MP0000716_abnormal_immune_system1.37035513
48MP0009046_muscle_twitch1.33299425
49MP0009333_abnormal_splenocyte_physiolog1.33195962
50MP0003172_abnormal_lysosome_physiology1.31487146
51MP0008007_abnormal_cellular_replicative1.29049687
52MP0005647_abnormal_sex_gland1.28687590
53MP0003646_muscle_fatigue1.28103936
54MP0008875_abnormal_xenobiotic_pharmacok1.24889250
55MP0008995_early_reproductive_senescence1.19556481
56MP0004130_abnormal_muscle_cell1.16305123
57MP0010155_abnormal_intestine_physiology1.14954386
58MP0001845_abnormal_inflammatory_respons1.14308621
59MP0001533_abnormal_skeleton_physiology1.14292181
60MP0003786_premature_aging1.12826903
61MP0002138_abnormal_hepatobiliary_system1.10707759
62MP0003300_gastrointestinal_ulcer1.08597622
63MP0001486_abnormal_startle_reflex1.07465884
64MP0008469_abnormal_protein_level1.06764378
65MP0009278_abnormal_bone_marrow1.06568784
66MP0002429_abnormal_blood_cell1.05568082
67MP0000689_abnormal_spleen_morphology1.05302556
68MP0003195_calcinosis1.04714746
69MP0002277_abnormal_respiratory_mucosa1.04559137
70MP0005389_reproductive_system_phenotype1.03030827
71MP0004808_abnormal_hematopoietic_stem1.02371917
72MP0001919_abnormal_reproductive_system1.01526026
73MP0002722_abnormal_immune_system1.00784306
74MP0004742_abnormal_vestibular_system0.98804447
75MP0001501_abnormal_sleep_pattern0.98451135
76MP0003111_abnormal_nucleus_morphology0.98214078
77MP0002876_abnormal_thyroid_physiology0.96569681
78MP0005397_hematopoietic_system_phenotyp0.95715336
79MP0001545_abnormal_hematopoietic_system0.95715336
80MP0004947_skin_inflammation0.93237555
81MP0001984_abnormal_olfaction0.91294163
82MP0002735_abnormal_chemical_nociception0.88440706
83MP0005083_abnormal_biliary_tract0.87643483
84MP0003011_delayed_dark_adaptation0.84762654
85MP0000920_abnormal_myelination0.83593366
86MP0001502_abnormal_circadian_rhythm0.83299443
87MP0003950_abnormal_plasma_membrane0.83056585
88MP0001188_hyperpigmentation0.83033126
89MP0001765_abnormal_ion_homeostasis0.82459055
90MP0000470_abnormal_stomach_morphology0.77783561
91MP0003453_abnormal_keratinocyte_physiol0.74235618
92MP0004233_abnormal_muscle_weight0.72896407
93MP0000358_abnormal_cell_content/0.72887949
94MP0002064_seizures0.72836227
95MP0003878_abnormal_ear_physiology0.72694726
96MP0005377_hearing/vestibular/ear_phenot0.72694726
97MP0009745_abnormal_behavioral_response0.71663862
98MP0002928_abnormal_bile_duct0.69873249
99MP0004134_abnormal_chest_morphology0.67828989
100MP0010307_abnormal_tumor_latency0.67486946
101MP0001346_abnormal_lacrimal_gland0.65334893
102MP0002736_abnormal_nociception_after0.60920428
103MP0003656_abnormal_erythrocyte_physiolo0.60739307
104MP0001756_abnormal_urination0.59645920
105MP0001119_abnormal_female_reproductive0.58188207
106MP0003632_abnormal_nervous_system0.57984272
107MP0001970_abnormal_pain_threshold0.57827182
108MP0002229_neurodegeneration0.57192479
109MP0001293_anophthalmia0.56323530
110MP0003077_abnormal_cell_cycle0.54716766
111MP0002405_respiratory_system_inflammati0.51037149
112MP0003699_abnormal_female_reproductive0.50285125
113MP0003115_abnormal_respiratory_system0.49278171
114MP0000427_abnormal_hair_cycle0.48762258
115MP0001851_eye_inflammation0.47475312
116MP0005174_abnormal_tail_pigmentation0.46671441
117MP0000015_abnormal_ear_pigmentation0.44796255
118MP0002102_abnormal_ear_morphology0.44347610
119MP0005076_abnormal_cell_differentiation0.43933385
120MP0003045_fibrosis0.42918225
121MP0000313_abnormal_cell_death0.41847287
122MP0005391_vision/eye_phenotype0.37126394
123MP0001324_abnormal_eye_pigmentation0.37041862
124MP0001730_embryonic_growth_arrest0.35041081
125MP0005636_abnormal_mineral_homeostasis0.34926024
126MP0005253_abnormal_eye_physiology0.34853954
127MP0003787_abnormal_imprinting0.34052627
128MP0002234_abnormal_pharynx_morphology0.32867133
129MP0003693_abnormal_embryo_hatching0.30158738
130MP0002092_abnormal_eye_morphology0.30152285
131MP0005551_abnormal_eye_electrophysiolog0.29879007
132MP0004264_abnormal_extraembryonic_tissu0.28418346
133MP0003763_abnormal_thymus_physiology0.27518805
134MP0009115_abnormal_fat_cell0.27338861
135MP0001835_abnormal_antigen_presentation0.26814186
136MP0004019_abnormal_vitamin_homeostasis0.26798630
137MP0002971_abnormal_brown_adipose0.26524955
138MP0005666_abnormal_adipose_tissue0.25770888
139MP0001764_abnormal_homeostasis0.25025440
140MP0003879_abnormal_hair_cell0.23654505
141MP0008961_abnormal_basal_metabolism0.22221180
142MP0001986_abnormal_taste_sensitivity0.21381937
143MP0001672_abnormal_embryogenesis/_devel0.20509819
144MP0005380_embryogenesis_phenotype0.20509819
145MP0003861_abnormal_nervous_system0.20336140
146MP0000703_abnormal_thymus_morphology0.19896477
147MP0003936_abnormal_reproductive_system0.19122008
148MP0000685_abnormal_immune_system0.18526861
149MP0002084_abnormal_developmental_patter0.18055101
150MP0002970_abnormal_white_adipose0.17794749
151MP0003183_abnormal_peptide_metabolism0.17664472
152MP0002398_abnormal_bone_marrow0.16186941
153MP0001727_abnormal_embryo_implantation0.15713058
154MP0002152_abnormal_brain_morphology0.15307223
155MP0002269_muscular_atrophy0.14269152
156MP0000432_abnormal_head_morphology0.14225936
157MP0004197_abnormal_fetal_growth/weight/0.13971947
158MP0002723_abnormal_immune_serum0.13501770
159MP0003984_embryonic_growth_retardation0.12927654
160MP0001784_abnormal_fluid_regulation0.12716068
161MP0001661_extended_life_span0.12606046
162MP0000647_abnormal_sebaceous_gland0.12344539
163MP0002108_abnormal_muscle_morphology0.11741585
164MP0003890_abnormal_embryonic-extraembry0.11385757
165MP0002019_abnormal_tumor_incidence0.11211043
166MP0001697_abnormal_embryo_size0.10953513
167MP0002088_abnormal_embryonic_growth/wei0.10914558

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.16534362
2Abnormal respiratory motile cilium morphology (HP:0005938)8.59461539
3Abnormal respiratory epithelium morphology (HP:0012253)8.59461539
4Rhinitis (HP:0012384)7.96900787
5Abnormal ciliary motility (HP:0012262)7.47213527
6Chronic bronchitis (HP:0004469)6.66257049
7Nasal polyposis (HP:0100582)6.55199774
8Infertility (HP:0000789)6.02856328
9Abnormality of the nasal mucosa (HP:0000433)5.35066641
10Attenuation of retinal blood vessels (HP:0007843)4.99994241
11Bronchiectasis (HP:0002110)4.85873878
12Nephronophthisis (HP:0000090)4.66199734
13Bronchitis (HP:0012387)4.61563529
14Stomatitis (HP:0010280)4.18552749
15Abnormality of the lower motor neuron (HP:0002366)4.09881887
16Optic neuritis (HP:0100653)3.88822955
17Retrobulbar optic neuritis (HP:0100654)3.88822955
18Orchitis (HP:0100796)3.70045044
19Abnormality of the renal medulla (HP:0100957)3.65473543
20Myositis (HP:0100614)3.59774558
21Dyschromatopsia (HP:0007641)3.56080605
22Keratoconjunctivitis (HP:0001096)3.55569045
23Chronic mucocutaneous candidiasis (HP:0002728)3.50126657
24Recurrent cutaneous fungal infections (HP:0011370)3.50126657
25Recurrent otitis media (HP:0000403)3.49318612
26Recurrent sinusitis (HP:0011108)3.44196178
27Bony spicule pigmentary retinopathy (HP:0007737)3.41812341
28Recurrent fungal infections (HP:0002841)3.40952141
29Decreased central vision (HP:0007663)3.31817474
30Gonadotropin excess (HP:0000837)3.29383134
31Recurrent bronchitis (HP:0002837)3.25101182
32Tubulointerstitial nephritis (HP:0001970)3.18772042
33Hypochromic anemia (HP:0001931)3.16944073
34Amyotrophic lateral sclerosis (HP:0007354)3.16028329
35Poikiloderma (HP:0001029)3.06868535
36Congenital stationary night blindness (HP:0007642)3.05067737
37Gastrointestinal infarctions (HP:0005244)3.01376581
38Mesangial abnormality (HP:0001966)3.01035085
39Rib fusion (HP:0000902)2.98948877
40Intestinal fistula (HP:0100819)2.96983185
41Rectal fistula (HP:0100590)2.92883944
42Rectovaginal fistula (HP:0000143)2.92883944
43Choroideremia (HP:0001139)2.92829662
44Flat occiput (HP:0005469)2.87398001
45Recurrent bacterial skin infections (HP:0005406)2.86663384
46Testicular atrophy (HP:0000029)2.85757729
47Fibular hypoplasia (HP:0003038)2.85097996
48Severe visual impairment (HP:0001141)2.84014730
49Decreased electroretinogram (ERG) amplitude (HP:0000654)2.83694791
50Pustule (HP:0200039)2.83613056
51Cheilitis (HP:0100825)2.82015517
52Keratoconjunctivitis sicca (HP:0001097)2.81607172
53Facial diplegia (HP:0001349)2.79610352
54Recurrent skin infections (HP:0001581)2.72111650
55Abnormal delayed hypersensitivity skin test (HP:0002963)2.70673593
56Vaginal fistula (HP:0004320)2.67645514
57Hemorrhage of the eye (HP:0011885)2.65839122
58Abnormal spermatogenesis (HP:0008669)2.65523823
59Eczematoid dermatitis (HP:0000976)2.63986571
60Male infertility (HP:0003251)2.63911696
61Impaired proprioception (HP:0010831)2.63544001
62Abnormality of macrophages (HP:0004311)2.63206542
63Recurrent abscess formation (HP:0002722)2.63043808
64Impulsivity (HP:0100710)2.60194353
65Upper motor neuron abnormality (HP:0002127)2.54904677
66Joint hemorrhage (HP:0005261)2.52761531
67Elevated erythrocyte sedimentation rate (HP:0003565)2.51905862
68Squamous cell carcinoma (HP:0002860)2.50465849
69Abnormal albumin level (HP:0012116)2.50151721
70Hypoalbuminemia (HP:0003073)2.50151721
71Annular pancreas (HP:0001734)2.47333517
72Autoimmune thrombocytopenia (HP:0001973)2.45444750
73Facial hemangioma (HP:0000329)2.44808188
74Degeneration of anterior horn cells (HP:0002398)2.43937770
75Abnormality of the anterior horn cell (HP:0006802)2.43937770
76Prolonged partial thromboplastin time (HP:0003645)2.42695786
77Tubulointerstitial abnormality (HP:0001969)2.42496777
78Tubular atrophy (HP:0000092)2.41025159
79Absent frontal sinuses (HP:0002688)2.40148954
80Abnormality of midbrain morphology (HP:0002418)2.38791760
81Molar tooth sign on MRI (HP:0002419)2.38791760
82Postaxial foot polydactyly (HP:0001830)2.36782169
83Encephalitis (HP:0002383)2.31548908
84Hypoplasia of the capital femoral epiphysis (HP:0003090)2.30919615
85Medial flaring of the eyebrow (HP:0010747)2.29157569
86Mediastinal lymphadenopathy (HP:0100721)2.28760582
87Anorexia (HP:0002039)2.27746158
88Genetic anticipation (HP:0003743)2.26676653
89Meningitis (HP:0001287)2.23945877
90Keratitis (HP:0000491)2.20734150
91Chronic hepatic failure (HP:0100626)2.19378762
92Vasculitis (HP:0002633)2.18054429
93Macular degeneration (HP:0000608)2.17470893
94Increased IgE level (HP:0003212)2.17452084
95Azoospermia (HP:0000027)2.16777114
96Abnormality of T cell number (HP:0011839)2.13111086
97Polyuria (HP:0000103)2.11643096
98Episodic fever (HP:0001954)2.11622635
99Akinesia (HP:0002304)2.10783571
100Congenital hepatic fibrosis (HP:0002612)2.07354566
101Abnormality of eosinophils (HP:0001879)2.06673962
102Hemoptysis (HP:0002105)2.06484717
103Abnormality of B cell number (HP:0010975)2.04309391
104Enlarged epiphyses (HP:0010580)2.04243565
105J-shaped sella turcica (HP:0002680)2.03732564
106Short ribs (HP:0000773)2.00317145
107Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.6504583
108Absent/shortened dynein arms (HP:0200106)12.1175132
109Dynein arm defect of respiratory motile cilia (HP:0012255)12.1175132
110Fetal akinesia sequence (HP:0001989)1.99737426
111Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.99685848
112Stage 5 chronic kidney disease (HP:0003774)1.99283727
113Stomach cancer (HP:0012126)1.98532710
114Abnormality of the costochondral junction (HP:0000919)1.97798190
115Supernumerary spleens (HP:0009799)1.97380394
116Recurrent gram-negative bacterial infections (HP:0005420)1.96241127
117Abnormality of the renal cortex (HP:0011035)1.95436049
118Short chin (HP:0000331)1.95387378
119Panhypogammaglobulinemia (HP:0003139)1.93194507
120Microglossia (HP:0000171)1.92606276
121Chronic sinusitis (HP:0011109)1.91952668
122Abnormality of T cells (HP:0002843)1.90421837
123Photophobia (HP:0000613)1.88708554
124Abnormality of the intrinsic pathway (HP:0010989)1.88511896
125Abnormal urine output (HP:0012590)1.88110814
126Renal dysplasia (HP:0000110)1.87938416
127Widely patent fontanelles and sutures (HP:0004492)1.87690762
128Chronic obstructive pulmonary disease (HP:0006510)1.87008080
129Obstructive lung disease (HP:0006536)1.87008080
130Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.86847819
131Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.86515316
132Abnormality of T cell physiology (HP:0011840)1.85569063
133Spastic tetraparesis (HP:0001285)1.85471405
134Abnormal rod and cone electroretinograms (HP:0008323)1.85388392
135Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.84797717
136Heterotopia (HP:0002282)1.84454886
137Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.83833854
138Absent epiphyses (HP:0010577)1.83833854
139Thin bony cortex (HP:0002753)1.83106467
140T lymphocytopenia (HP:0005403)1.80755194
141Facial cleft (HP:0002006)1.78818319
14211 pairs of ribs (HP:0000878)1.78194412
143Gangrene (HP:0100758)1.77804689
144Oculomotor apraxia (HP:0000657)1.76940879
145Abnormality of permanent molar morphology (HP:0011071)1.73924608
146Abnormality of the dental root (HP:0006486)1.73924608
147Taurodontia (HP:0000679)1.73924608
148Aplasia/Hypoplasia of the fibula (HP:0006492)1.71667824
149Inflammation of the large intestine (HP:0002037)1.71524390
150Conjunctival telangiectasia (HP:0000524)1.71250451
151Leukocytosis (HP:0001974)1.71238644
152Eosinophilia (HP:0001880)1.71137187
153Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.71099520
154Hypoplasia of the pons (HP:0012110)1.70784955
155Short thorax (HP:0010306)1.70767083
156Tubulointerstitial fibrosis (HP:0005576)1.70350188
157Pulmonary infiltrates (HP:0002113)1.69966468
158Abnormality of dentin (HP:0010299)1.69630484
159Bell-shaped thorax (HP:0001591)1.68062230
160Median cleft lip (HP:0000161)1.67354903
161Abnormality of molar morphology (HP:0011070)1.64795079
162Abnormality of molar (HP:0011077)1.64795079
163Postaxial hand polydactyly (HP:0001162)1.59939540
164Abnormal drinking behavior (HP:0030082)1.59917586
165Polydipsia (HP:0001959)1.59917586
166Deformed sella turcica (HP:0002681)1.58268114
167Abnormality of the dental pulp (HP:0006479)1.56375450
168Abnormal biliary tract physiology (HP:0012439)1.50011499
169Bile duct proliferation (HP:0001408)1.50011499
170Aplasia/Hypoplasia of the tongue (HP:0010295)1.48866728
171Ectopic kidney (HP:0000086)1.44432553
172Breast carcinoma (HP:0003002)1.43900132
173Decreased motor nerve conduction velocity (HP:0003431)1.42265262
174Nephropathy (HP:0000112)1.42238939
175Cholecystitis (HP:0001082)1.40377281
176Abnormal gallbladder physiology (HP:0012438)1.40377281
177Cystic liver disease (HP:0006706)1.37536432
178Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.36614006
179Abnormality of ocular smooth pursuit (HP:0000617)1.36275402
180Abnormality of the vasculature of the conjunctiva (HP:0008054)1.35764735
181Gaze-evoked nystagmus (HP:0000640)1.34641234
182Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.34497816
183Abnormality of renal excretion (HP:0011036)1.34374541
184Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.32755871
185Pachygyria (HP:0001302)1.32434201
186Sloping forehead (HP:0000340)1.32144390
187Hypoplasia of dental enamel (HP:0006297)1.32091042
188Abnormality of the frontal sinuses (HP:0002687)1.31314649
189Nephroblastoma (Wilms tumor) (HP:0002667)1.30507488
190Broad distal phalanx of finger (HP:0009836)1.29865771
191Large eyes (HP:0001090)1.29527121
192Pancreatic fibrosis (HP:0100732)1.27662311

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK48.84584796
2PDK38.84584796
3PDK25.70672288
4TESK14.31122855
5PRKD33.62888045
6PNCK3.20384403
7ICK2.97122575
8BLK2.79941938
9MAP3K132.61299889
10WNK42.55095008
11MAP3K142.54617418
12TAOK32.46056986
13PTK2B2.43550379
14IRAK42.37342296
15STK392.32738530
16NEK22.12818386
17MAP2K32.01840211
18FRK1.83784009
19TLK11.79730641
20IKBKB1.78397286
21GRK61.77776964
22SIK21.71956534
23ADRBK21.68771919
24TNK21.61125635
25MAP3K111.57933357
26ACVR1B1.54523937
27TYK21.47017405
28IKBKE1.45770418
29ZAK1.44331844
30IRAK31.42233757
31WNK11.39699756
32MAPK151.30969024
33CDC71.30944125
34FGR1.29687610
35SYK1.25093193
36DAPK21.23109208
37STK31.22669228
38STK381.21301033
39FES1.19731235
40CCNB11.17291451
41ERN11.13141894
42LYN1.05044050
43DYRK1B1.03617692
44OXSR11.02815406
45CAMK1G0.99106781
46PASK0.98719486
47HCK0.97887294
48JAK20.93178527
49MAP3K70.92082886
50ITK0.87422555
51KIT0.86192880
52BMPR1B0.83611857
53ATR0.82953230
54JAK10.82431177
55JAK30.82424432
56MATK0.82237253
57INSRR0.82115602
58CDK120.78608487
59TYRO30.78214967
60CHUK0.75628021
61WEE10.75114068
62TTK0.74393225
63PDK10.73540952
64BTK0.72891791
65MAP3K10.72778887
66DYRK30.72269997
67PLK40.70912547
68MAPK110.68969229
69ADRBK10.68567680
70CHEK10.67671172
71MAPK120.67525401
72PINK10.66007149
73PRKAA20.64395718
74PRKD20.63683742
75LCK0.63080184
76PRKCH0.60190978
77IRAK10.57210921
78RPS6KA60.57069888
79CHEK20.56194911
80MAP3K30.55952953
81MAPK70.54056236
82ATM0.52212980
83PRKCZ0.51632299
84SGK10.49657430
85RPS6KA50.49217792
86SGK4940.42529859
87SGK2230.42529859
88MTOR0.42519953
89EPHB10.42069135
90CAMKK20.40427783
91RPS6KC10.39657461
92RPS6KL10.39657461
93PLK10.39391148
94TRIB30.36484035
95RIPK40.36344810
96SGK30.35933266
97LMTK20.29213760
98STK38L0.28928488
99YES10.28096418
100PRKAA10.27355442
101RPS6KB10.22472719
102NEK60.22203095
103CDK30.21050858
104BRD40.20929675
105TXK0.19039131
106PAK10.18683919
107MARK30.18361219
108NTRK20.17873477
109MAP2K60.16226413
110EEF2K0.16089936
111PAK20.15705903
112TBK10.15626822
113MAP4K10.15087080
114CAMKK10.14064071
115ZAP700.13679844
116CDK10.13089550
117MARK20.11668643
118PRKCG0.11260049
119CSNK1D0.10876162
120MAP2K70.10673016
121CDK20.10492715
122PRKDC0.09503538
123GSK3B0.09389741
124PDPK10.08450030
125TESK20.08318939
126CSK0.08279180
127WNK30.07907819
128BRSK20.07666327
129MAPK80.06656037
130PRKCQ0.06035873
131PIM10.04760996
132CDK70.04756888
133CSNK2A10.04607245
134PRKACB0.04257969
135MAPK10.04082371
136EGFR0.03950031
137CDK40.03916014
138CSF1R0.03601763
139MAP3K40.03552109
140PRKG10.03465341
141IRAK20.03464387
142PDGFRB0.02886169
143MAPK100.01816139
144STK100.01642733
145PRKCB0.01636693
146CLK10.01151185
147MAPK140.00551604
148TAOK10.00405162
149PRKACG0.00145662
150STK110.00140819
151CDK6-0.0329519
152RPS6KA1-0.0299607
153LATS1-0.0289345
154AURKB-0.0225458
155MAP3K5-0.0157824
156PKN1-0.0131740
157MUSK-0.0103163
158RPS6KA3-0.0038266
159CSNK2A2-0.0018510

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007504.20413129
2Dorso-ventral axis formation_Homo sapiens_hsa043203.92816670
3Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.77130461
4Pyruvate metabolism_Homo sapiens_hsa006203.69308369
5Fanconi anemia pathway_Homo sapiens_hsa034603.58337953
6Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006043.07976325
7Basal transcription factors_Homo sapiens_hsa030223.00065174
8Glucagon signaling pathway_Homo sapiens_hsa049222.80279711
9Propanoate metabolism_Homo sapiens_hsa006402.76752338
10Selenocompound metabolism_Homo sapiens_hsa004502.76524832
11Fatty acid biosynthesis_Homo sapiens_hsa000612.62276530
12alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.54836054
13NOD-like receptor signaling pathway_Homo sapiens_hsa046212.42822464
14Linoleic acid metabolism_Homo sapiens_hsa005912.37745946
15Pentose phosphate pathway_Homo sapiens_hsa000302.26785415
16Primary immunodeficiency_Homo sapiens_hsa053402.25306322
17Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.05993848
18Oocyte meiosis_Homo sapiens_hsa041142.00764705
19Allograft rejection_Homo sapiens_hsa053301.90218123
20Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.87944183
21Glycerolipid metabolism_Homo sapiens_hsa005611.85686224
22Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.83794077
23Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.83167552
24RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.80258241
25Leishmaniasis_Homo sapiens_hsa051401.80121015
26mRNA surveillance pathway_Homo sapiens_hsa030151.77906554
27Carbohydrate digestion and absorption_Homo sapiens_hsa049731.76240731
28NF-kappa B signaling pathway_Homo sapiens_hsa040641.75987573
29Toll-like receptor signaling pathway_Homo sapiens_hsa046201.71144513
30Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.70386959
31Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.67697806
32Staphylococcus aureus infection_Homo sapiens_hsa051501.66844876
33Autoimmune thyroid disease_Homo sapiens_hsa053201.66229399
34Tuberculosis_Homo sapiens_hsa051521.65347510
35Huntingtons disease_Homo sapiens_hsa050161.62216394
36Antigen processing and presentation_Homo sapiens_hsa046121.59348081
37RNA transport_Homo sapiens_hsa030131.57579124
38Intestinal immune network for IgA production_Homo sapiens_hsa046721.55900885
39Sulfur relay system_Homo sapiens_hsa041221.54164530
40TNF signaling pathway_Homo sapiens_hsa046681.53181766
41Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.49421178
42Fructose and mannose metabolism_Homo sapiens_hsa000511.38876929
43ABC transporters_Homo sapiens_hsa020101.38854600
44Type I diabetes mellitus_Homo sapiens_hsa049401.36034227
45Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.35490163
46Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.31802825
47Amphetamine addiction_Homo sapiens_hsa050311.28615547
48Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.28461143
49Glycerophospholipid metabolism_Homo sapiens_hsa005641.27047013
50African trypanosomiasis_Homo sapiens_hsa051431.26631222
51Glycosaminoglycan degradation_Homo sapiens_hsa005311.26518355
52Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.25930279
53Renin secretion_Homo sapiens_hsa049241.23617599
54Hematopoietic cell lineage_Homo sapiens_hsa046401.22097695
55Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.22024308
56PPAR signaling pathway_Homo sapiens_hsa033201.20798648
57Malaria_Homo sapiens_hsa051441.19565008
58Legionellosis_Homo sapiens_hsa051341.18810300
59Cysteine and methionine metabolism_Homo sapiens_hsa002701.17287015
60Chemokine signaling pathway_Homo sapiens_hsa040621.15058109
61Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.08299311
62Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.01983201
63Homologous recombination_Homo sapiens_hsa034401.01539721
64Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.01293339
65Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.98177260
66Purine metabolism_Homo sapiens_hsa002300.97690873
67Ether lipid metabolism_Homo sapiens_hsa005650.95873526
68Phototransduction_Homo sapiens_hsa047440.92931284
69Ovarian steroidogenesis_Homo sapiens_hsa049130.90594516
70Olfactory transduction_Homo sapiens_hsa047400.90310087
71Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.89523567
72Morphine addiction_Homo sapiens_hsa050320.87682967
73Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.85399620
74N-Glycan biosynthesis_Homo sapiens_hsa005100.84673674
75Carbon metabolism_Homo sapiens_hsa012000.84413322
76Nitrogen metabolism_Homo sapiens_hsa009100.80611309
77Nicotine addiction_Homo sapiens_hsa050330.80207717
78MAPK signaling pathway_Homo sapiens_hsa040100.79021517
79Acute myeloid leukemia_Homo sapiens_hsa052210.79014905
80Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.75939675
81Rheumatoid arthritis_Homo sapiens_hsa053230.75682217
82mTOR signaling pathway_Homo sapiens_hsa041500.74960435
83FoxO signaling pathway_Homo sapiens_hsa040680.74473387
84RNA degradation_Homo sapiens_hsa030180.73797178
85Measles_Homo sapiens_hsa051620.72381599
86Pertussis_Homo sapiens_hsa051330.71830631
87Asthma_Homo sapiens_hsa053100.71407268
88Circadian rhythm_Homo sapiens_hsa047100.70983395
89Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.69970718
90Lysosome_Homo sapiens_hsa041420.69761352
91Apoptosis_Homo sapiens_hsa042100.69038953
92Hepatitis B_Homo sapiens_hsa051610.68921051
93Mineral absorption_Homo sapiens_hsa049780.68915555
94Hepatitis C_Homo sapiens_hsa051600.68043588
95Influenza A_Homo sapiens_hsa051640.64966489
96Phosphatidylinositol signaling system_Homo sapiens_hsa040700.63514438
97Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.63402917
98Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.62962252
99B cell receptor signaling pathway_Homo sapiens_hsa046620.62878672
100Estrogen signaling pathway_Homo sapiens_hsa049150.62791672
101Regulation of autophagy_Homo sapiens_hsa041400.62772768
102Cardiac muscle contraction_Homo sapiens_hsa042600.62727658
103Neurotrophin signaling pathway_Homo sapiens_hsa047220.59860603
104Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.59364118
105Central carbon metabolism in cancer_Homo sapiens_hsa052300.58538802
106Inositol phosphate metabolism_Homo sapiens_hsa005620.58474100
107Fat digestion and absorption_Homo sapiens_hsa049750.58267269
108Calcium signaling pathway_Homo sapiens_hsa040200.57729689
109Long-term potentiation_Homo sapiens_hsa047200.56586667
110Cell cycle_Homo sapiens_hsa041100.54646951
111Arachidonic acid metabolism_Homo sapiens_hsa005900.53734403
112Other glycan degradation_Homo sapiens_hsa005110.53114281
113Adipocytokine signaling pathway_Homo sapiens_hsa049200.50855062
114Fatty acid metabolism_Homo sapiens_hsa012120.49658528
115Phospholipase D signaling pathway_Homo sapiens_hsa040720.48559461
116cAMP signaling pathway_Homo sapiens_hsa040240.47691150
117Sphingolipid metabolism_Homo sapiens_hsa006000.47540315
118Biosynthesis of amino acids_Homo sapiens_hsa012300.47415171
119T cell receptor signaling pathway_Homo sapiens_hsa046600.47329916
120Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.47318435
121VEGF signaling pathway_Homo sapiens_hsa043700.46864685
122Insulin resistance_Homo sapiens_hsa049310.46158336
123Transcriptional misregulation in cancer_Homo sapiens_hsa052020.45812389
124Endocytosis_Homo sapiens_hsa041440.44049899
125cGMP-PKG signaling pathway_Homo sapiens_hsa040220.43544272
126Hedgehog signaling pathway_Homo sapiens_hsa043400.41799479
127Viral carcinogenesis_Homo sapiens_hsa052030.41736694
128Non-homologous end-joining_Homo sapiens_hsa034500.40946098
129Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.40130217
130AMPK signaling pathway_Homo sapiens_hsa041520.39905873
131Salmonella infection_Homo sapiens_hsa051320.39067299
132Toxoplasmosis_Homo sapiens_hsa051450.38672526
133Herpes simplex infection_Homo sapiens_hsa051680.38139043
134Taste transduction_Homo sapiens_hsa047420.37636865
135Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.36945003
136Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.36232971
137Osteoclast differentiation_Homo sapiens_hsa043800.36091301
138Sphingolipid signaling pathway_Homo sapiens_hsa040710.35763465
139Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.34829115
140Type II diabetes mellitus_Homo sapiens_hsa049300.33880595
141Fatty acid degradation_Homo sapiens_hsa000710.32120238
142Systemic lupus erythematosus_Homo sapiens_hsa053220.32113594
143Vitamin digestion and absorption_Homo sapiens_hsa049770.32038000
144Epstein-Barr virus infection_Homo sapiens_hsa051690.31915839
145Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.30271474
146HTLV-I infection_Homo sapiens_hsa051660.30218739
147Pyrimidine metabolism_Homo sapiens_hsa002400.29462548
148Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.29201214
149Insulin secretion_Homo sapiens_hsa049110.27712178
150Longevity regulating pathway - mammal_Homo sapiens_hsa042110.24731300
151Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.24111212
152p53 signaling pathway_Homo sapiens_hsa041150.23468298
153Thyroid hormone signaling pathway_Homo sapiens_hsa049190.22518019
154Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.21582838
155Chemical carcinogenesis_Homo sapiens_hsa052040.20038517
156Graft-versus-host disease_Homo sapiens_hsa053320.19421597
157Wnt signaling pathway_Homo sapiens_hsa043100.17759219
158Circadian entrainment_Homo sapiens_hsa047130.15292877
159Renin-angiotensin system_Homo sapiens_hsa046140.13463629
160Metabolic pathways_Homo sapiens_hsa011000.12999258
161Jak-STAT signaling pathway_Homo sapiens_hsa046300.12334059
162HIF-1 signaling pathway_Homo sapiens_hsa040660.11448544

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