DNAH2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Dyneins are microtubule-associated motor protein complexes composed of several heavy, light, and intermediate chains. The axonemal dyneins, found in cilia and flagella, are components of the outer and inner dynein arms attached to the peripheral microtubule doublets. DNAH2 is an axonemal inner arm dynein heavy chain (Chapelin et al., 1997 [PubMed 9256245]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1male meiosis (GO:0007140)9.53819230
2epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)9.53512734
3cell-cell recognition (GO:0009988)9.30849755
4binding of sperm to zona pellucida (GO:0007339)9.29130549
5plasma membrane fusion (GO:0045026)9.22495412
6motile cilium assembly (GO:0044458)9.02968521
7acrosome reaction (GO:0007340)8.95800810
8reproduction (GO:0000003)8.63417083
9synaptonemal complex organization (GO:0070193)8.45000264
10spermatid development (GO:0007286)8.39302339
11regulation of cilium movement (GO:0003352)8.19912035
12synaptonemal complex assembly (GO:0007130)8.19071247
13cell wall macromolecule metabolic process (GO:0044036)7.48302192
14cell wall macromolecule catabolic process (GO:0016998)7.48302192
15single fertilization (GO:0007338)7.12822262
16sperm capacitation (GO:0048240)7.06370524
17DNA methylation involved in gamete generation (GO:0043046)6.97470377
18male meiosis I (GO:0007141)6.56200690
19ventricular system development (GO:0021591)6.51355560
20fertilization (GO:0009566)6.11785005
21chromosome organization involved in meiosis (GO:0070192)5.71920203
22vitamin transmembrane transport (GO:0035461)5.65262752
23primary alcohol catabolic process (GO:0034310)5.52922016
24meiotic nuclear division (GO:0007126)5.51787497
25meiosis I (GO:0007127)5.35622467
26meiotic cell cycle (GO:0051321)5.29502914
27negative regulation of inclusion body assembly (GO:0090084)5.27957537
28spermatogenesis (GO:0007283)5.19434153
29male gamete generation (GO:0048232)5.17608351
30cellular process involved in reproduction in multicellular organism (GO:0022412)5.02073365
31germ cell development (GO:0007281)5.01993443
32regulation of microtubule-based movement (GO:0060632)5.00356204
33microtubule severing (GO:0051013)4.93362023
34protein localization to cilium (GO:0061512)4.85258624
35response to xenobiotic stimulus (GO:0009410)4.81221636
36ethanol metabolic process (GO:0006067)4.78154381
37gamete generation (GO:0007276)4.76127842
38seminiferous tubule development (GO:0072520)4.73787913
39gene silencing by RNA (GO:0031047)4.70905647
40diterpenoid biosynthetic process (GO:0016102)4.63193695
41one-carbon compound transport (GO:0019755)4.63120157
42cell recognition (GO:0008037)4.56323323
43intraciliary transport (GO:0042073)4.54207912
44axoneme assembly (GO:0035082)4.47813933
45negative regulation of T cell differentiation in thymus (GO:0033085)4.37631482
46left/right pattern formation (GO:0060972)4.36086919
47genitalia morphogenesis (GO:0035112)4.27146595
48monoubiquitinated protein deubiquitination (GO:0035520)4.26536896
49negative regulation of organelle assembly (GO:1902116)4.26110328
50protein polyglutamylation (GO:0018095)4.25647713
51cell projection assembly (GO:0030031)4.21129989
52regulation of inclusion body assembly (GO:0090083)4.20692089
53regulation of centriole replication (GO:0046599)4.19965187
54lung epithelium development (GO:0060428)4.19900885
55calcium ion-dependent exocytosis (GO:0017156)4.15724369
56pyrimidine-containing compound transmembrane transport (GO:0072531)4.11932020
57microtubule depolymerization (GO:0007019)4.01710922
58organic cation transport (GO:0015695)4.00054269
59* microtubule-based movement (GO:0007018)3.97085191
60tolerance induction (GO:0002507)3.82262671
61retinoic acid metabolic process (GO:0042573)3.77008984
62exogenous drug catabolic process (GO:0042738)3.76083674
63glomerular epithelial cell development (GO:0072310)3.75281154
64lateral ventricle development (GO:0021670)3.74148110
65multicellular organismal reproductive process (GO:0048609)3.73351158
66negative regulation of humoral immune response (GO:0002921)3.68443015
67regulation of germinal center formation (GO:0002634)3.64341103
68regulation of meiosis I (GO:0060631)3.62726179
69establishment of apical/basal cell polarity (GO:0035089)3.62035191
70regulation of interleukin-5 production (GO:0032674)3.59057601
71negative regulation of B cell mediated immunity (GO:0002713)3.55948574
72negative regulation of immunoglobulin mediated immune response (GO:0002890)3.55948574
73meiotic cell cycle process (GO:1903046)3.53624300
74photoreceptor cell maintenance (GO:0045494)3.53151520
75cilium organization (GO:0044782)3.52301660
76regulation of protein polyubiquitination (GO:1902914)3.48539780
77cytoplasmic microtubule organization (GO:0031122)3.47292941
78microtubule polymerization or depolymerization (GO:0031109)3.44488399
79nuclear pore complex assembly (GO:0051292)3.44479906
80ethanol oxidation (GO:0006069)3.41946616
81establishment or maintenance of monopolar cell polarity (GO:0061339)3.41761217
82establishment of monopolar cell polarity (GO:0061162)3.41761217
83centriole replication (GO:0007099)3.41376395
84terpenoid biosynthetic process (GO:0016114)3.37260238
85cilium assembly (GO:0042384)3.33146504
86regulation of interleukin-13 production (GO:0032656)3.29925133
87synapsis (GO:0007129)3.28806019
88drug catabolic process (GO:0042737)3.26772506
89carnitine transmembrane transport (GO:1902603)3.25160234
90spermatid nucleus differentiation (GO:0007289)3.19055642
91determination of left/right symmetry (GO:0007368)3.18284692
92amino-acid betaine transport (GO:0015838)3.17952405
93carnitine transport (GO:0015879)3.17952405
94cellular component assembly involved in morphogenesis (GO:0010927)3.14670282
95cilium morphogenesis (GO:0060271)3.13914092
96nonmotile primary cilium assembly (GO:0035058)3.11900665
97cornea development in camera-type eye (GO:0061303)3.10694202
98negative regulation of DNA repair (GO:0045738)3.10097639
99smoothened signaling pathway (GO:0007224)3.08979943
100chaperone-mediated protein complex assembly (GO:0051131)3.04905024
101centriole assembly (GO:0098534)3.03390733
102gene silencing (GO:0016458)3.02701901
103determination of bilateral symmetry (GO:0009855)3.00834308
104retinal cone cell development (GO:0046549)3.00133334
105multicellular organismal development (GO:0007275)2.98892789
106nucleoside diphosphate phosphorylation (GO:0006165)2.98756650
107glutathione derivative metabolic process (GO:1901685)2.98397724
108glutathione derivative biosynthetic process (GO:1901687)2.98397724
109retinol metabolic process (GO:0042572)2.97422472
110alditol metabolic process (GO:0019400)2.96590332
111left/right axis specification (GO:0070986)2.95496255
112specification of symmetry (GO:0009799)2.93827679
113lactate metabolic process (GO:0006089)2.90813974
114peptidyl-glutamic acid modification (GO:0018200)2.85815021
115positive regulation of tolerance induction (GO:0002645)2.84593876
116regulation of spindle checkpoint (GO:0090231)2.82464268
117rRNA catabolic process (GO:0016075)2.80644025
118O-glycan processing (GO:0016266)2.79164356
119thyroid hormone metabolic process (GO:0042403)2.76529694
120nuclear pore organization (GO:0006999)2.76331904
121pore complex assembly (GO:0046931)2.75315102
122primary alcohol metabolic process (GO:0034308)2.74600261
123DNA alkylation (GO:0006305)2.72589354
124DNA methylation (GO:0006306)2.72589354
125organelle assembly (GO:0070925)2.70416397
126glycerol metabolic process (GO:0006071)2.68764165
127retinal rod cell development (GO:0046548)2.68558116
128establishment of planar polarity (GO:0001736)2.67749051
129establishment of tissue polarity (GO:0007164)2.67749051
130carnitine metabolic process (GO:0009437)2.66643496
131positive regulation of smoothened signaling pathway (GO:0045880)2.64545590
132phosphatidylethanolamine biosynthetic process (GO:0006646)2.62889788
133phosphatidylcholine biosynthetic process (GO:0006656)2.59333508
134mitotic sister chromatid cohesion (GO:0007064)2.58894984
135thyroid hormone generation (GO:0006590)2.56586333
136regulation of chromatin binding (GO:0035561)2.52916144
137excretion (GO:0007588)2.52040978
138hydrogen peroxide biosynthetic process (GO:0050665)2.51134146
139benzene-containing compound metabolic process (GO:0042537)2.50851784
140microtubule bundle formation (GO:0001578)2.49874233
141sex differentiation (GO:0007548)2.49545413
142protein refolding (GO:0042026)2.49061305
143aldehyde catabolic process (GO:0046185)2.48927182
144phosphatidylethanolamine metabolic process (GO:0046337)2.47605434
145negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.47281131
146regulation of collateral sprouting (GO:0048670)2.45605128
147nucleus organization (GO:0006997)2.44726326
148protein K11-linked deubiquitination (GO:0035871)2.43869366
149regulation of histone H3-K9 methylation (GO:0051570)2.40048624
150regulation of cilium assembly (GO:1902017)2.38483733
151regulation of acrosome reaction (GO:0060046)2.37427551
152polyol catabolic process (GO:0046174)2.36511231
153* microtubule-based process (GO:0007017)2.36458723
154sialylation (GO:0097503)2.35906588
155reactive oxygen species biosynthetic process (GO:1903409)2.34793998
156protein O-linked glycosylation (GO:0006493)2.31008300
157androgen biosynthetic process (GO:0006702)2.30396041
158* cilium or flagellum-dependent cell motility (GO:0001539)18.4127321
159fusion of sperm to egg plasma membrane (GO:0007342)12.1099231
160piRNA metabolic process (GO:0034587)12.0058950
161axonemal dynein complex assembly (GO:0070286)11.9922948
162multicellular organism reproduction (GO:0032504)10.8923626
163sperm motility (GO:0030317)10.7426527
164sperm-egg recognition (GO:0035036)10.4267584
165acrosome assembly (GO:0001675)10.3704880
166epithelial cilium movement (GO:0003351)10.1293563
167cilium movement (GO:0003341)10.0541762

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.36397317
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse5.51032064
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.90898935
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.19555867
5DROSHA_22980978_ChIP-Seq_HELA_Human3.09579078
6ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.01599625
7CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.59667627
8FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.51514007
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.31507781
10PCGF2_27294783_Chip-Seq_ESCs_Mouse2.22516206
11GATA1_26923725_Chip-Seq_HPCs_Mouse2.08968966
12GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.07635477
13PIAS1_25552417_ChIP-Seq_VCAP_Human2.06443878
14CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.05230376
15MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse11.1537676
16ELK4_26923725_Chip-Seq_MESODERM_Mouse1.92869557
17ZNF274_21170338_ChIP-Seq_K562_Hela1.91505525
18PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.90903611
19EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.88541373
20GBX2_23144817_ChIP-Seq_PC3_Human1.84505795
21PCGF2_27294783_Chip-Seq_NPCs_Mouse1.82948554
22AHR_22903824_ChIP-Seq_MCF-7_Human1.77539837
23NR3C1_21868756_ChIP-Seq_MCF10A_Human1.75304778
24VDR_22108803_ChIP-Seq_LS180_Human1.71447147
25ARNT_22903824_ChIP-Seq_MCF-7_Human1.67502876
26ESR1_20079471_ChIP-ChIP_T-47D_Human1.66570554
27EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.62851340
28NFE2_27457419_Chip-Seq_LIVER_Mouse1.62019971
29KAP1_22055183_ChIP-Seq_ESCs_Mouse1.58896631
30ER_23166858_ChIP-Seq_MCF-7_Human1.57749773
31TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.57603937
32AR_21572438_ChIP-Seq_LNCaP_Human1.57154236
33SMAD4_21799915_ChIP-Seq_A2780_Human1.56864899
34SUZ12_27294783_Chip-Seq_NPCs_Mouse1.55963345
35CTBP1_25329375_ChIP-Seq_LNCAP_Human1.55838936
36NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.54476247
37KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.53364040
38WDR5_24793694_ChIP-Seq_LNCAP_Human1.52382718
39FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.48886419
40ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.48526240
41IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.48078638
42CBP_20019798_ChIP-Seq_JUKART_Human1.48078638
43* STAT3_23295773_ChIP-Seq_U87_Human1.46130517
44FOXM1_26456572_ChIP-Seq_MCF-7_Human1.44309348
45STAT1_17558387_ChIP-Seq_HELA_Human1.39755294
46GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.38357978
47AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.37737306
48TOP2B_26459242_ChIP-Seq_MCF-7_Human1.37556962
49AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.37263920
50TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.37007818
51REST_21632747_ChIP-Seq_MESCs_Mouse1.36303026
52SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.34879970
53ETV1_20927104_ChIP-Seq_GIST48_Human1.34651818
54FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.34089737
55POU3F2_20337985_ChIP-ChIP_501MEL_Human1.33529547
56CBX2_27304074_Chip-Seq_ESCs_Mouse1.32999734
57* STAT1_20625510_ChIP-Seq_HELA_Human1.32888101
58PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.32547105
59RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.32392594
60TP63_23658742_ChIP-Seq_EP156T_Human1.31935541
61SMRT_27268052_Chip-Seq_Bcells_Human1.30950792
62TAF15_26573619_Chip-Seq_HEK293_Human1.30144870
63TAL1_26923725_Chip-Seq_HPCs_Mouse1.29561144
64TCF4_22108803_ChIP-Seq_LS180_Human1.29537076
65GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29129886
66STAT6_21828071_ChIP-Seq_BEAS2B_Human1.28097132
67ZNF217_24962896_ChIP-Seq_MCF-7_Human1.27999468
68TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.27410937
69CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.25922980
70AR_25329375_ChIP-Seq_VCAP_Human1.25800375
71PHF8_20622853_ChIP-Seq_HELA_Human1.24442549
72TP53_16413492_ChIP-PET_HCT116_Human1.24067205
73PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.22767251
74FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.21907586
75FOXA1_25552417_ChIP-Seq_VCAP_Human1.20706284
76AR_20517297_ChIP-Seq_VCAP_Human1.20267609
77TP53_18474530_ChIP-ChIP_U2OS_Human1.19532246
78SMAD3_21741376_ChIP-Seq_EPCs_Human1.18751434
79RNF2_27304074_Chip-Seq_NSC_Mouse1.17358335
80FLI1_21867929_ChIP-Seq_TH2_Mouse1.17019169
81SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.16970562
82POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.16924842
83TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16924842
84TDRD3_21172665_ChIP-Seq_MCF-7_Human1.16569731
85KDM2B_26808549_Chip-Seq_REH_Human1.16544235
86OCT4_18555785_Chip-Seq_ESCs_Mouse1.16337471
87EZH2_27294783_Chip-Seq_NPCs_Mouse1.15866190
88MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.15538215
89HNFA_21074721_ChIP-Seq_CACO-2_Human1.14911142
90CRX_20693478_ChIP-Seq_RETINA_Mouse1.14410710
91SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.13698452
92FOXA1_21572438_ChIP-Seq_LNCaP_Human1.13347273
93EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.12283737
94RBPJ_21746931_ChIP-Seq_IB4_Human1.12110908
95NANOG_18555785_Chip-Seq_ESCs_Mouse1.12016078
96NCOR_22424771_ChIP-Seq_293T_Human1.10563737
97RUNX2_22187159_ChIP-Seq_PCA_Human1.10400031
98RUNX1_26923725_Chip-Seq_HPCs_Mouse1.09891246
99ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.09843650
100LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.09783330
101P300_19829295_ChIP-Seq_ESCs_Human1.09776646
102ZFP57_27257070_Chip-Seq_ESCs_Mouse1.09425158
103OCT4_21477851_ChIP-Seq_ESCs_Mouse1.09205737
104CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.08979874
105ESR1_21235772_ChIP-Seq_MCF-7_Human1.08814500
106FUS_26573619_Chip-Seq_HEK293_Human1.08042474
107PRDM14_20953172_ChIP-Seq_ESCs_Human1.08038555
108IGF1R_20145208_ChIP-Seq_DFB_Human1.07960184
109MYC_19829295_ChIP-Seq_ESCs_Human1.07890064
110GATA3_21867929_ChIP-Seq_CD8_Mouse1.07858705
111VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.07484122
112ESRRB_18555785_Chip-Seq_ESCs_Mouse1.07207682
113BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.07091494
114KLF4_18555785_Chip-Seq_ESCs_Mouse1.07001455
115GF1_26923725_Chip-Seq_HPCs_Mouse1.06497330
116CDX2_22108803_ChIP-Seq_LS180_Human1.06415669
117SMAD3_21741376_ChIP-Seq_HESCs_Human1.06332344
118NFYA_21822215_ChIP-Seq_K562_Human1.05912726
119P300_18555785_Chip-Seq_ESCs_Mouse1.05421736
120CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.05319213
121STAT3_18555785_Chip-Seq_ESCs_Mouse1.04825470
122CBX2_22325352_ChIP-Seq_293T-Rex_Human1.04760564
123CTBP2_25329375_ChIP-Seq_LNCAP_Human1.04284045
124* GATA3_21878914_ChIP-Seq_MCF-7_Human1.04063454
125TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.03712122
126HOXB7_26014856_ChIP-Seq_BT474_Human1.03508516
127P53_22387025_ChIP-Seq_ESCs_Mouse1.03386345
128EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.03378305
129EWS_26573619_Chip-Seq_HEK293_Human1.03217480
130STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.03032977
131MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.02528594
132SALL1_21062744_ChIP-ChIP_HESCs_Human1.02300671
133* EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.01269976
134CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.01268923
135TCF4_23295773_ChIP-Seq_U87_Human1.00922167
136GATA3_21867929_ChIP-Seq_TH1_Mouse1.00210645
137* CEBPB_22108803_ChIP-Seq_LS180_Human1.00188424
138OCT4_20526341_ChIP-Seq_ESCs_Human0.99342419
139CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.99123701
140GATA4_25053715_ChIP-Seq_YYC3_Human0.98532631
141RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.98143767
142SOX2_22085726_ChIP-Seq_NPCs_Mouse0.98108344
143GATA6_21074721_ChIP-Seq_CACO-2_Human0.97605425
144ERA_21632823_ChIP-Seq_H3396_Human0.97146564
145EZH2_27294783_Chip-Seq_ESCs_Mouse0.96924171
146TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96571375
147CTNNB1_20460455_ChIP-Seq_HCT116_Human0.95959879
148CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95141127
149RUNX1_27457419_Chip-Seq_LIVER_Mouse0.94487196
150RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.94067614
151SUZ12_18555785_Chip-Seq_ESCs_Mouse0.93909347
152PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.93250109
153CMYC_18555785_Chip-Seq_ESCs_Mouse0.92904265
154ZFX_18555785_Chip-Seq_ESCs_Mouse0.90108089
155BCAT_22108803_ChIP-Seq_LS180_Human0.89274774
156RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.89065332
157CTCF_18555785_Chip-Seq_ESCs_Mouse0.88456946
158RAD21_21589869_ChIP-Seq_MESCs_Mouse0.87630117
159MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.87490383
160PU1_27457419_Chip-Seq_LIVER_Mouse0.85796907
161FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.85397235
162E2F1_18555785_Chip-Seq_ESCs_Mouse0.84903998
163P53_21459846_ChIP-Seq_SAOS-2_Human0.84400954
164SPI1_26923725_Chip-Seq_HPCs_Mouse0.84353359
165PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.84141377
166SOX2_21211035_ChIP-Seq_LN229_Human0.83603538
167GF1B_26923725_Chip-Seq_HPCs_Mouse0.83166977
168TBL1_22424771_ChIP-Seq_293T_Human0.83094903
169NFYB_21822215_ChIP-Seq_K562_Human0.82427685
170FOXA1_27270436_Chip-Seq_PROSTATE_Human0.82043786
171FOXA1_25329375_ChIP-Seq_VCAP_Human0.82043786
172SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.81402059
173SMAD1_18555785_Chip-Seq_ESCs_Mouse0.81133160
174SMAD4_21741376_ChIP-Seq_EPCs_Human0.80912646
175SOX2_18555785_Chip-Seq_ESCs_Mouse0.80716496

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008875_abnormal_xenobiotic_pharmacok6.39738281
2MP0003698_abnormal_male_reproductive5.77037319
3MP0008877_abnormal_DNA_methylation5.50789415
4MP0002653_abnormal_ependyma_morphology5.49101901
5MP0001929_abnormal_gametogenesis5.31546897
6MP0004043_abnormal_pH_regulation4.15133092
7MP0002210_abnormal_sex_determination3.93571765
8MP0005623_abnormal_meninges_morphology3.87514991
9MP0002132_abnormal_respiratory_system3.80291104
10MP0001145_abnormal_male_reproductive3.32852833
11MP0009780_abnormal_chondrocyte_physiolo3.23187278
12MP0002161_abnormal_fertility/fecundity3.11888422
13MP0002277_abnormal_respiratory_mucosa3.05291110
14MP0000653_abnormal_sex_gland2.88376624
15MP0000383_abnormal_hair_follicle2.38135839
16MP0008057_abnormal_DNA_replication2.28657745
17MP0008789_abnormal_olfactory_epithelium2.28247155
18MP0009046_muscle_twitch2.12217023
19MP0003195_calcinosis2.04145668
20MP0002876_abnormal_thyroid_physiology2.00455542
21MP0005410_abnormal_fertilization13.7306461
22MP0005083_abnormal_biliary_tract1.99931096
23MP0002282_abnormal_trachea_morphology1.88817349
24MP0002160_abnormal_reproductive_system1.81732767
25MP0002168_other_aberrant_phenotype1.79704484
26MP0002735_abnormal_chemical_nociception1.67472929
27MP0010678_abnormal_skin_adnexa1.67087582
28MP0008058_abnormal_DNA_repair1.62516262
29MP0001485_abnormal_pinna_reflex1.59543190
30MP0002909_abnormal_adrenal_gland1.59399076
31MP0002638_abnormal_pupillary_reflex1.57500744
32MP0008872_abnormal_physiological_respon1.54659931
33MP0003646_muscle_fatigue1.52932674
34MP0000566_synostosis1.51180818
35MP0005394_taste/olfaction_phenotype1.48303283
36MP0005499_abnormal_olfactory_system1.48303283
37MP0010094_abnormal_chromosome_stability1.42015183
38MP0005646_abnormal_pituitary_gland1.41058649
39MP0005395_other_phenotype1.32696015
40MP0001501_abnormal_sleep_pattern1.21207069
41MP0002734_abnormal_mechanical_nocicepti1.21051774
42MP0005645_abnormal_hypothalamus_physiol1.19316045
43MP0003656_abnormal_erythrocyte_physiolo1.17007018
44MP0003136_yellow_coat_color1.16530834
45MP0009745_abnormal_behavioral_response1.14622348
46MP0001486_abnormal_startle_reflex1.13886584
47MP0005085_abnormal_gallbladder_physiolo1.13203426
48MP0005310_abnormal_salivary_gland1.11373512
49MP0005670_abnormal_white_adipose1.11371140
50MP0001970_abnormal_pain_threshold1.09609463
51MP0005647_abnormal_sex_gland1.08333801
52MP0001968_abnormal_touch/_nociception1.05013825
53MP0008007_abnormal_cellular_replicative1.02913831
54MP0000569_abnormal_digit_pigmentation1.02869152
55MP0008995_early_reproductive_senescence1.02589361
56MP0002229_neurodegeneration1.00047897
57MP0001502_abnormal_circadian_rhythm0.99160205
58MP0001984_abnormal_olfaction0.98467167
59MP0005389_reproductive_system_phenotype0.97745723
60MP0000631_abnormal_neuroendocrine_gland0.94910766
61MP0005220_abnormal_exocrine_pancreas0.93579670
62MP0003786_premature_aging0.92454736
63MP0001986_abnormal_taste_sensitivity0.92347544
64MP0005365_abnormal_bile_salt0.92141167
65MP0003718_maternal_effect0.89843194
66MP0004233_abnormal_muscle_weight0.88378297
67MP0003111_abnormal_nucleus_morphology0.85041196
68MP0000026_abnormal_inner_ear0.84748721
69MP0001765_abnormal_ion_homeostasis0.83004303
70MP0005195_abnormal_posterior_eye0.82525429
71MP0009643_abnormal_urine_homeostasis0.80691271
72MP0002272_abnormal_nervous_system0.79487019
73MP0002928_abnormal_bile_duct0.78943903
74MP0000358_abnormal_cell_content/0.78361153
75MP0003878_abnormal_ear_physiology0.77207756
76MP0005377_hearing/vestibular/ear_phenot0.77207756
77MP0000678_abnormal_parathyroid_gland0.76793570
78MP0001963_abnormal_hearing_physiology0.76696579
79MP0002557_abnormal_social/conspecific_i0.76274385
80MP0001664_abnormal_digestion0.76204801
81MP0002102_abnormal_ear_morphology0.75417652
82MP0006276_abnormal_autonomic_nervous0.75084272
83MP0003950_abnormal_plasma_membrane0.73500627
84MP0003252_abnormal_bile_duct0.71085713
85MP0000681_abnormal_thyroid_gland0.70773093
86MP0002136_abnormal_kidney_physiology0.70578314
87MP0005165_increased_susceptibility_to0.68365515
88MP0002249_abnormal_larynx_morphology0.66124189
89MP0004134_abnormal_chest_morphology0.66002259
90MP0004085_abnormal_heartbeat0.63535221
91MP0002733_abnormal_thermal_nociception0.63174016
92MP0010307_abnormal_tumor_latency0.62719378
93MP0002064_seizures0.62601462
94MP0001944_abnormal_pancreas_morphology0.61859221
95MP0004808_abnormal_hematopoietic_stem0.61600072
96MP0004142_abnormal_muscle_tone0.60782556
97MP0004885_abnormal_endolymph0.60655622
98MP0001293_anophthalmia0.60578320
99MP0002234_abnormal_pharynx_morphology0.60019625
100MP0001905_abnormal_dopamine_level0.59884632
101MP0001270_distended_abdomen0.59394075
102MP0010386_abnormal_urinary_bladder0.58675301
103MP0003115_abnormal_respiratory_system0.58312264
104MP0002067_abnormal_sensory_capabilities0.57684360
105MP0005164_abnormal_response_to0.57313230
106MP0003943_abnormal_hepatobiliary_system0.57175933
107MP0001545_abnormal_hematopoietic_system0.56576005
108MP0005397_hematopoietic_system_phenotyp0.56576005
109MP0002736_abnormal_nociception_after0.55244340
110MP0010155_abnormal_intestine_physiology0.55044846
111MP0001346_abnormal_lacrimal_gland0.54447903
112MP0009278_abnormal_bone_marrow0.54174886
113MP0003329_amyloid_beta_deposits0.52785723
114MP0001730_embryonic_growth_arrest0.51573477
115MP0003699_abnormal_female_reproductive0.51497776
116MP0003011_delayed_dark_adaptation0.51016310
117MP0005076_abnormal_cell_differentiation0.49400051
118MP0001119_abnormal_female_reproductive0.46541337
119MP0003861_abnormal_nervous_system0.44753871
120MP0000427_abnormal_hair_cycle0.42743321
121MP0002084_abnormal_developmental_patter0.40665370
122MP0002152_abnormal_brain_morphology0.40568316
123MP0006138_congestive_heart_failure0.40240888
124MP0003045_fibrosis0.39816669
125MP0005391_vision/eye_phenotype0.39296715
126MP0004133_heterotaxia0.38933850
127MP0001440_abnormal_grooming_behavior0.38084842
128MP0005253_abnormal_eye_physiology0.37676070
129MP0003077_abnormal_cell_cycle0.37314452
130MP0002092_abnormal_eye_morphology0.33648372
131MP0003879_abnormal_hair_cell0.33551832
132MP0000313_abnormal_cell_death0.32844959
133MP0003693_abnormal_embryo_hatching0.32304741
134MP0002971_abnormal_brown_adipose0.31468339
135MP0001851_eye_inflammation0.30441876
136MP0004019_abnormal_vitamin_homeostasis0.30325010
137MP0004264_abnormal_extraembryonic_tissu0.29703078
138MP0005551_abnormal_eye_electrophysiolog0.27891227
139MP0000432_abnormal_head_morphology0.27541204
140MP0002572_abnormal_emotion/affect_behav0.27375069
141MP0000647_abnormal_sebaceous_gland0.27138623
142MP0004811_abnormal_neuron_physiology0.26951025
143MP0001672_abnormal_embryogenesis/_devel0.26761627
144MP0005380_embryogenesis_phenotype0.26761627
145MP0005636_abnormal_mineral_homeostasis0.25795998
146MP0002108_abnormal_muscle_morphology0.25657782
147MP0006072_abnormal_retinal_apoptosis0.25244659
148MP0002133_abnormal_respiratory_system0.24681819
149MP0005388_respiratory_system_phenotype0.24681819
150MP0000955_abnormal_spinal_cord0.23855326
151MP0000778_abnormal_nervous_system0.23589354
152MP0002295_abnormal_pulmonary_circulatio0.23567445
153MP0009703_decreased_birth_body0.23157093
154MP0001324_abnormal_eye_pigmentation0.23069159
155MP0004036_abnormal_muscle_relaxation0.22856596
156MP0000604_amyloidosis0.22669676
157MP0004270_analgesia0.22667189
158MP0001697_abnormal_embryo_size0.22293940
159MP0003283_abnormal_digestive_organ0.22119823
160MP0002085_abnormal_embryonic_tissue0.21516393
161MP0003936_abnormal_reproductive_system0.21171449
162MP0005666_abnormal_adipose_tissue0.21150107
163MP0003634_abnormal_glial_cell0.21087956
164MP0002269_muscular_atrophy0.20744093
165MP0002116_abnormal_craniofacial_bone0.20674851
166MP0003633_abnormal_nervous_system0.20364414
167MP0004197_abnormal_fetal_growth/weight/0.19147297
168MP0003984_embryonic_growth_retardation0.18850658
169MP0003631_nervous_system_phenotype0.18065118

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.90210583
2Abnormal respiratory motile cilium morphology (HP:0005938)8.63457036
3Abnormal respiratory epithelium morphology (HP:0012253)8.63457036
4Abnormal ciliary motility (HP:0012262)8.53203065
5Rhinitis (HP:0012384)8.44896446
6Chronic bronchitis (HP:0004469)6.77883426
7Nasal polyposis (HP:0100582)6.60167394
8Infertility (HP:0000789)5.92723578
9Abnormality of the nasal mucosa (HP:0000433)5.44577193
10Bronchiectasis (HP:0002110)5.07603545
11Bronchitis (HP:0012387)4.50192960
12Nephronophthisis (HP:0000090)4.46682959
13Abnormality of the lower motor neuron (HP:0002366)3.88599155
14Pancreatic cysts (HP:0001737)3.83824264
15Abnormality of the renal medulla (HP:0100957)3.45320018
16Recurrent otitis media (HP:0000403)3.37717649
17Recurrent sinusitis (HP:0011108)3.36472875
18Chronic hepatic failure (HP:0100626)3.26317175
19Recurrent bronchitis (HP:0002837)2.98399316
20Amyotrophic lateral sclerosis (HP:0007354)2.97802584
21Fibular hypoplasia (HP:0003038)2.93179622
22Male infertility (HP:0003251)2.92240804
23Chronic otitis media (HP:0000389)2.89369113
24Gonadotropin excess (HP:0000837)2.81598443
25Tubulointerstitial nephritis (HP:0001970)2.76743060
26Hyperactive renin-angiotensin system (HP:0000841)2.69488258
27Molar tooth sign on MRI (HP:0002419)2.59029725
28Abnormality of midbrain morphology (HP:0002418)2.59029725
29Abnormal spermatogenesis (HP:0008669)2.52795011
30Medial flaring of the eyebrow (HP:0010747)2.45977407
31Atelectasis (HP:0100750)2.43651742
32Microglossia (HP:0000171)2.39997430
33Impulsivity (HP:0100710)2.36601072
34Decreased circulating renin level (HP:0003351)2.36378702
35Anencephaly (HP:0002323)2.34285631
36Tubular atrophy (HP:0000092)2.29229335
37Postaxial foot polydactyly (HP:0001830)2.28943924
38Tubulointerstitial abnormality (HP:0001969)2.28801295
39J-shaped sella turcica (HP:0002680)2.26887878
40Absent frontal sinuses (HP:0002688)2.25320370
41Male pseudohermaphroditism (HP:0000037)2.24986361
42Sclerocornea (HP:0000647)2.18948660
43Upper motor neuron abnormality (HP:0002127)2.16078025
44Azoospermia (HP:0000027)2.14994563
45Impaired proprioception (HP:0010831)2.10666973
46Congenital hepatic fibrosis (HP:0002612)2.10482362
47Supernumerary spleens (HP:0009799)2.07218413
48Aplasia/Hypoplasia of the spleen (HP:0010451)2.05609551
49Furrowed tongue (HP:0000221)2.05185382
50Hypoplasia of the capital femoral epiphysis (HP:0003090)2.05094920
51Chronic sinusitis (HP:0011109)2.02328525
52Facial cleft (HP:0002006)2.01172532
53Respiratory insufficiency due to defective ciliary clearance (HP:0200073)14.1499924
54Absent/shortened dynein arms (HP:0200106)11.6645377
55Dynein arm defect of respiratory motile cilia (HP:0012255)11.6645377
56Short ribs (HP:0000773)1.99374790
57Abnormality of the anterior horn cell (HP:0006802)1.99253816
58Degeneration of anterior horn cells (HP:0002398)1.99253816
59Median cleft lip (HP:0000161)1.98428217
60Asplenia (HP:0001746)1.98340625
61Stage 5 chronic kidney disease (HP:0003774)1.91884860
62Absent rod-and cone-mediated responses on ERG (HP:0007688)1.89186383
63Decreased central vision (HP:0007663)1.88532548
64Aplasia/Hypoplasia of the fibula (HP:0006492)1.86862013
65Abnormality of permanent molar morphology (HP:0011071)1.86395716
66Abnormality of the dental root (HP:0006486)1.86395716
67Taurodontia (HP:0000679)1.86395716
68Pancreatic fibrosis (HP:0100732)1.84356821
69Renal dysplasia (HP:0000110)1.84004756
70Spastic tetraparesis (HP:0001285)1.82172291
71Hyperkalemia (HP:0002153)1.80383781
72Tubulointerstitial fibrosis (HP:0005576)1.79673036
73Aplasia/Hypoplasia of the tongue (HP:0010295)1.79407299
74Oculomotor apraxia (HP:0000657)1.78534340
75Renal salt wasting (HP:0000127)1.78353656
7611 pairs of ribs (HP:0000878)1.76397616
77Abnormality of dentin (HP:0010299)1.75810161
78Abnormality of molar morphology (HP:0011070)1.75100981
79Abnormality of molar (HP:0011077)1.75100981
80Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.74595237
81Hyperaldosteronism (HP:0000859)1.70154443
82Abnormal rod and cone electroretinograms (HP:0008323)1.69089167
83Abnormality of the dental pulp (HP:0006479)1.67610111
84Postaxial hand polydactyly (HP:0001162)1.65714742
85Abnormality of renin-angiotensin system (HP:0000847)1.64619394
86Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.63968060
87Absent epiphyses (HP:0010577)1.63968060
88Abnormality of the renal cortex (HP:0011035)1.62987837
89Short thorax (HP:0010306)1.59005248
90Preaxial hand polydactyly (HP:0001177)1.58190956
91Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.58070767
92Cystic liver disease (HP:0006706)1.56728489
93Absent speech (HP:0001344)1.54090078
94Genital tract atresia (HP:0001827)1.53628160
95Deformed sella turcica (HP:0002681)1.52897484
96Gait imbalance (HP:0002141)1.52454088
97Bell-shaped thorax (HP:0001591)1.50338792
98Congenital primary aphakia (HP:0007707)1.50165450
99Polydipsia (HP:0001959)1.49896380
100Abnormal drinking behavior (HP:0030082)1.49896380
101Vaginal atresia (HP:0000148)1.49177519
102Heterotopia (HP:0002282)1.49095620
103Abnormal biliary tract physiology (HP:0012439)1.48067260
104Bile duct proliferation (HP:0001408)1.48067260
105Conjunctival telangiectasia (HP:0000524)1.46637392
106Abnormality of chloride homeostasis (HP:0011422)1.46516884
107Abnormality of ocular smooth pursuit (HP:0000617)1.45265093
108Hypokalemic alkalosis (HP:0001949)1.42597847
109Bony spicule pigmentary retinopathy (HP:0007737)1.40339474
110Retinitis pigmentosa (HP:0000510)1.40055254
111Breast carcinoma (HP:0003002)1.39625564
112Pachygyria (HP:0001302)1.38679402
113Nephropathy (HP:0000112)1.37124642
114Selective tooth agenesis (HP:0001592)1.36556425
115Broad distal phalanx of finger (HP:0009836)1.35872571
116True hermaphroditism (HP:0010459)1.34812423
117Cone-rod dystrophy (HP:0000548)1.34810577
118Abolished electroretinogram (ERG) (HP:0000550)1.34684118
119Congenital stationary night blindness (HP:0007642)1.31858255
120Abnormality of macular pigmentation (HP:0008002)1.29794264
121Type II lissencephaly (HP:0007260)1.29417027
122Polyuria (HP:0000103)1.28558425
123Decreased motor nerve conduction velocity (HP:0003431)1.26887990
124Hypoplasia of dental enamel (HP:0006297)1.25762963
125Nephrogenic diabetes insipidus (HP:0009806)1.25591224
126Abnormality of renal excretion (HP:0011036)1.24447383
127Gaze-evoked nystagmus (HP:0000640)1.23659615
128Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.22856391
129Nephroblastoma (Wilms tumor) (HP:0002667)1.20953994
130Occipital encephalocele (HP:0002085)1.19686175
131Poor coordination (HP:0002370)1.18184725
132Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.18111245
133Abnormality of the frontal sinuses (HP:0002687)1.17701564
134Prominent nasal bridge (HP:0000426)1.13782208
135Attenuation of retinal blood vessels (HP:0007843)1.11483996
136Multicystic kidney dysplasia (HP:0000003)1.09651726
137Narrow forehead (HP:0000341)1.09412684
138Aganglionic megacolon (HP:0002251)1.09215946
139Hyperventilation (HP:0002883)1.09136527
140Highly arched eyebrow (HP:0002553)1.08979526
141Central scotoma (HP:0000603)1.06744798
142Glucose intolerance (HP:0000833)1.06588167
143Disproportionate short-trunk short stature (HP:0003521)1.05307302
144Spinal muscular atrophy (HP:0007269)1.02827451
145Portal hypertension (HP:0001409)1.01601765

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK38.37169043
2PDK48.37169043
3PDK25.41132678
4MST44.91414849
5FRK4.81349598
6TESK13.76000042
7PNCK3.68491395
8PRKD33.63915711
9EPHA23.50719156
10WNK43.05852705
11ICK2.89878744
12STK392.83639437
13PTK2B2.71810937
14MAPKAPK32.52457684
15NME12.19767630
16INSRR2.17538222
17NEK22.15047273
18TLK12.06262645
19MAPK151.99809893
20MAP4K21.69514798
21ADRBK21.67292644
22GRK11.66442916
23WNK11.51011788
24STK381.50679270
25BCR1.48740622
26WEE11.44859711
27MST1R1.42404954
28OXSR11.25488714
29STK31.22943590
30TRPM71.18988467
31TYRO31.18644214
32BMPR1B1.12940387
33EPHA31.12514371
34CDC71.08735913
35MAP3K71.06943467
36CCNB11.05352580
37TTK1.04871551
38PASK1.00589620
39PRKCI0.98042727
40FER0.95734218
41TXK0.95237709
42MAPK130.90151800
43ADRBK10.89204496
44MAP3K20.88048525
45CAMK1G0.86526781
46STK240.86183618
47LMTK20.85189183
48MAPKAPK50.83689050
49CDK120.79940860
50DYRK30.79905830
51DYRK1B0.79724861
52ERBB30.75690166
53CHEK10.72028592
54PRKAA20.69120268
55PDK10.68889942
56CAMKK20.68672920
57TAOK30.67921494
58NTRK20.67815006
59ATR0.67294571
60CHEK20.66915382
61MET0.66901850
62ACVR1B0.65568435
63PLK40.64629860
64ZAK0.64595243
65ERBB20.63749066
66STK38L0.62504382
67EPHB10.61960259
68HIPK20.61270554
69PRKCE0.59881429
70NLK0.57831796
71NTRK30.54125401
72NUAK10.53732741
73PINK10.51677170
74ATM0.49862646
75STK160.49594163
76BRSK20.48685247
77SMG10.48470273
78CASK0.48359043
79PLK10.47956520
80MAP3K30.46002451
81MTOR0.45870814
82IRAK10.45120191
83CHUK0.40508972
84SGK10.38262517
85PRKCA0.37520261
86PRKACA0.37469434
87CAMK2A0.37342074
88PRKAA10.35146721
89CDK190.34061891
90PAK30.33019370
91TBK10.32964527
92CAMKK10.32923204
93MAP3K40.31917236
94DYRK20.29929785
95PRKCD0.29822815
96PHKG20.28955721
97PHKG10.28955721
98PRKCG0.28782969
99NEK60.27380864
100IKBKB0.27293029
101PAK10.27217709
102TIE10.26416740
103ABL10.26237280
104DYRK1A0.25839141
105BRAF0.25162634
106MARK10.24772689
107PAK60.23915181
108PAK20.23664307
109TEC0.23475142
110TGFBR10.23423171
111TNK20.22981458
112IGF1R0.22729177
113WNK30.21567711
114CAMK2G0.21019196
115BUB10.19748138
116PRKCH0.19481499
117SIK20.19123577
118CDK30.18996685
119RPS6KB10.18305196
120PDPK10.18068526
121MAP2K70.17947081
122STK110.17773148
123PRKDC0.16836356
124RIPK40.16598989
125CDK10.16172598
126RIPK10.15614073
127BRSK10.15532730
128PDGFRB0.14765599
129CDK20.14427091
130MAPK100.14303504
131TAOK10.13152493
132GSK3B0.12548375
133MAPK80.12454482
134CSNK1D0.10290383
135PRKACB0.09302693
136MARK20.08308406
137TESK20.08082169
138AKT30.06364619
139MARK30.06009387
140RPS6KA30.05668027
141PRKACG0.05277595
142DDR20.04862188
143EGFR0.04848489
144PRKG10.04538301
145PRKCZ0.04449574
146CSNK2A10.03882184
147MAP3K90.03237622
148CSNK1E0.02879776
149CSNK2A20.02605510
150LATS10.02232698
151RPS6KA10.02037256
152PRKCB0.01621678
153AURKA0.01453178
154MAPK10.01371561
155EPHA40.01228195
156MAPK140.01166796
157MAP2K60.01144089
158PRKCQ0.01085371
159EEF2K0.00491752
160ZAP70-0.0147197
161CSK-0.0146489
162SRPK1-0.0125119
163STK10-0.0105082
164CDK5-0.0086773
165MUSK-0.0073964

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007504.74715424
2Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009804.22961156
3Dorso-ventral axis formation_Homo sapiens_hsa043204.19486894
4Chemical carcinogenesis_Homo sapiens_hsa052043.66446657
5Histidine metabolism_Homo sapiens_hsa003403.50916953
6Pyruvate metabolism_Homo sapiens_hsa006203.32601081
7Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.22768594
8Fanconi anemia pathway_Homo sapiens_hsa034603.10525723
9Pentose phosphate pathway_Homo sapiens_hsa000303.04658562
10Phenylalanine metabolism_Homo sapiens_hsa003603.03976305
11Basal transcription factors_Homo sapiens_hsa030223.00682068
12Glucagon signaling pathway_Homo sapiens_hsa049222.71325137
13Caffeine metabolism_Homo sapiens_hsa002322.50004714
14Tyrosine metabolism_Homo sapiens_hsa003502.49935494
15Propanoate metabolism_Homo sapiens_hsa006402.47208716
16Oocyte meiosis_Homo sapiens_hsa041142.45764736
17beta-Alanine metabolism_Homo sapiens_hsa004102.44971284
18Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.38689072
19Fatty acid biosynthesis_Homo sapiens_hsa000612.28647047
20Huntingtons disease_Homo sapiens_hsa050162.23065672
21Retinol metabolism_Homo sapiens_hsa008302.17386156
22alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.14027523
23Selenocompound metabolism_Homo sapiens_hsa004502.12533253
24Linoleic acid metabolism_Homo sapiens_hsa005912.04564803
25Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.03756268
26Phototransduction_Homo sapiens_hsa047441.92990433
27Amphetamine addiction_Homo sapiens_hsa050311.84584542
28Steroid hormone biosynthesis_Homo sapiens_hsa001401.82838163
29RNA transport_Homo sapiens_hsa030131.73754516
30Glycerolipid metabolism_Homo sapiens_hsa005611.71351266
31mRNA surveillance pathway_Homo sapiens_hsa030151.71205583
32Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.71060298
33Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.64466694
34Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.57662084
35Carbohydrate digestion and absorption_Homo sapiens_hsa049731.56910246
36Glycerophospholipid metabolism_Homo sapiens_hsa005641.55894562
37Renin secretion_Homo sapiens_hsa049241.52651306
38Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.49460424
39Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.43070327
40Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.38262960
41PPAR signaling pathway_Homo sapiens_hsa033201.28318304
42Peroxisome_Homo sapiens_hsa041461.26409558
43Fructose and mannose metabolism_Homo sapiens_hsa000511.26284707
44Butanoate metabolism_Homo sapiens_hsa006501.25625598
45Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.24523277
46Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.23913823
47Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.22953047
48Glycosaminoglycan degradation_Homo sapiens_hsa005311.20474708
49Nitrogen metabolism_Homo sapiens_hsa009101.19293428
50Tryptophan metabolism_Homo sapiens_hsa003801.14516136
51Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.14135803
52Primary bile acid biosynthesis_Homo sapiens_hsa001201.12593090
53Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.11314531
54Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.10322434
55Cysteine and methionine metabolism_Homo sapiens_hsa002701.09514579
56Long-term potentiation_Homo sapiens_hsa047201.07658337
57Fat digestion and absorption_Homo sapiens_hsa049751.07040093
58Renin-angiotensin system_Homo sapiens_hsa046141.05493670
59Antigen processing and presentation_Homo sapiens_hsa046121.04012593
60Cardiac muscle contraction_Homo sapiens_hsa042601.01795218
61Intestinal immune network for IgA production_Homo sapiens_hsa046720.99991047
62Circadian rhythm_Homo sapiens_hsa047100.99185529
63Carbon metabolism_Homo sapiens_hsa012000.99180696
64ABC transporters_Homo sapiens_hsa020100.98899605
65Mineral absorption_Homo sapiens_hsa049780.98863382
66Estrogen signaling pathway_Homo sapiens_hsa049150.93701884
67Ether lipid metabolism_Homo sapiens_hsa005650.93665129
68Purine metabolism_Homo sapiens_hsa002300.93344106
69Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.89794602
70Serotonergic synapse_Homo sapiens_hsa047260.89368943
71Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.88246271
72Calcium signaling pathway_Homo sapiens_hsa040200.80937488
73Type I diabetes mellitus_Homo sapiens_hsa049400.78663882
74Tight junction_Homo sapiens_hsa045300.77394836
75Biosynthesis of amino acids_Homo sapiens_hsa012300.77112969
76Asthma_Homo sapiens_hsa053100.76960498
77Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.76277333
78Maturity onset diabetes of the young_Homo sapiens_hsa049500.75761191
79Insulin secretion_Homo sapiens_hsa049110.73237886
80Graft-versus-host disease_Homo sapiens_hsa053320.70478467
81Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.69368664
82Regulation of autophagy_Homo sapiens_hsa041400.65762855
83Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.65741434
84cGMP-PKG signaling pathway_Homo sapiens_hsa040220.65404129
85Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.64624936
86N-Glycan biosynthesis_Homo sapiens_hsa005100.64361992
87Phosphatidylinositol signaling system_Homo sapiens_hsa040700.64357489
88Homologous recombination_Homo sapiens_hsa034400.64264855
89Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.63644738
90Taste transduction_Homo sapiens_hsa047420.63361606
91AMPK signaling pathway_Homo sapiens_hsa041520.62218948
92Endocytosis_Homo sapiens_hsa041440.62118839
93Hedgehog signaling pathway_Homo sapiens_hsa043400.61861783
94Allograft rejection_Homo sapiens_hsa053300.61438083
95Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.60630020
96Starch and sucrose metabolism_Homo sapiens_hsa005000.60477572
97Pentose and glucuronate interconversions_Homo sapiens_hsa000400.59450453
98Circadian entrainment_Homo sapiens_hsa047130.58631689
99Cell cycle_Homo sapiens_hsa041100.58009877
100Autoimmune thyroid disease_Homo sapiens_hsa053200.57474672
101RNA degradation_Homo sapiens_hsa030180.57158010
102Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.57058850
103Cyanoamino acid metabolism_Homo sapiens_hsa004600.55354188
104Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.53335136
105Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.51343989
106Metabolic pathways_Homo sapiens_hsa011000.50495177
107Inositol phosphate metabolism_Homo sapiens_hsa005620.50047280
108VEGF signaling pathway_Homo sapiens_hsa043700.49537256
109Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.48779628
110Collecting duct acid secretion_Homo sapiens_hsa049660.47464590
111Fatty acid metabolism_Homo sapiens_hsa012120.47053545
112Adipocytokine signaling pathway_Homo sapiens_hsa049200.46943272
113Drug metabolism - other enzymes_Homo sapiens_hsa009830.44075741
114Central carbon metabolism in cancer_Homo sapiens_hsa052300.43474260
115Cocaine addiction_Homo sapiens_hsa050300.42875479
116Longevity regulating pathway - mammal_Homo sapiens_hsa042110.41370316
117Lysine degradation_Homo sapiens_hsa003100.41185466
118Olfactory transduction_Homo sapiens_hsa047400.40674487
119Sphingolipid metabolism_Homo sapiens_hsa006000.39367020
120SNARE interactions in vesicular transport_Homo sapiens_hsa041300.39315979
121Glutamatergic synapse_Homo sapiens_hsa047240.38731646
122Synaptic vesicle cycle_Homo sapiens_hsa047210.37543922
123Wnt signaling pathway_Homo sapiens_hsa043100.37532485
124Thyroid hormone synthesis_Homo sapiens_hsa049180.36649416
125cAMP signaling pathway_Homo sapiens_hsa040240.36044755
126Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.35209561
127Arachidonic acid metabolism_Homo sapiens_hsa005900.34543259
128Morphine addiction_Homo sapiens_hsa050320.33061689
129Choline metabolism in cancer_Homo sapiens_hsa052310.32742868
130Hematopoietic cell lineage_Homo sapiens_hsa046400.32199356
131Thyroid hormone signaling pathway_Homo sapiens_hsa049190.32123517
132Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.31643491
133Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.31173219
134Type II diabetes mellitus_Homo sapiens_hsa049300.30923145
135Vascular smooth muscle contraction_Homo sapiens_hsa042700.30805176
136Gastric acid secretion_Homo sapiens_hsa049710.30532478
137Salivary secretion_Homo sapiens_hsa049700.29992140
138Viral carcinogenesis_Homo sapiens_hsa052030.29580328
139Legionellosis_Homo sapiens_hsa051340.27339277
140Pancreatic secretion_Homo sapiens_hsa049720.27196614
141Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.27059602
142Protein digestion and absorption_Homo sapiens_hsa049740.26859190
143Fatty acid degradation_Homo sapiens_hsa000710.26147234
144Dopaminergic synapse_Homo sapiens_hsa047280.25670412
145Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.25538330
146Aldosterone synthesis and secretion_Homo sapiens_hsa049250.25080244
147Transcriptional misregulation in cancer_Homo sapiens_hsa052020.24891408
148Oxytocin signaling pathway_Homo sapiens_hsa049210.24259790
149Bile secretion_Homo sapiens_hsa049760.24241922
150Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.23672241
151Ovarian steroidogenesis_Homo sapiens_hsa049130.23632925
152Vitamin digestion and absorption_Homo sapiens_hsa049770.23188729
153Salmonella infection_Homo sapiens_hsa051320.23158353
154Nicotine addiction_Homo sapiens_hsa050330.22732350
155Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.21185972
156Epstein-Barr virus infection_Homo sapiens_hsa051690.20061507
157Jak-STAT signaling pathway_Homo sapiens_hsa046300.19960384
158Glutathione metabolism_Homo sapiens_hsa004800.19414071

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