DNAH3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the dynein family, whose members encode large proteins that are constituents of the microtubule-associated motor protein complex. This complex is composed of dynein heavy, intermediate and light chains, which can be axonemal or cytoplasmic. This protein is an axonemal dynein heavy chain. It is involved in producing force for ciliary beating by using energy from ATP hydrolysis. Alternative splicing results in multiple transcript variants encoding distinct isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1reproduction (GO:0000003)9.93633315
2acrosome reaction (GO:0007340)9.42026074
3cell-cell recognition (GO:0009988)9.31822693
4epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)8.56870591
5binding of sperm to zona pellucida (GO:0007339)8.47335135
6spermatid development (GO:0007286)8.00116825
7single fertilization (GO:0007338)7.69611472
8regulation of cilium movement (GO:0003352)7.41348073
9piRNA metabolic process (GO:0034587)7.16374651
10male meiosis (GO:0007140)6.91386664
11ventricular system development (GO:0021591)6.88120656
12primary alcohol catabolic process (GO:0034310)6.60551819
13sperm capacitation (GO:0048240)6.46594183
14vitamin transmembrane transport (GO:0035461)6.27658581
15synaptonemal complex organization (GO:0070193)6.12713113
16fertilization (GO:0009566)6.12110144
17synaptonemal complex assembly (GO:0007130)5.74761874
18ethanol metabolic process (GO:0006067)5.62155625
19diterpenoid biosynthetic process (GO:0016102)5.60969247
20spermatogenesis (GO:0007283)5.19319367
21male gamete generation (GO:0048232)5.16981493
22microtubule depolymerization (GO:0007019)5.16800188
23axoneme assembly (GO:0035082)5.12066006
24response to xenobiotic stimulus (GO:0009410)5.09790500
25negative regulation of inclusion body assembly (GO:0090084)4.93518845
26pyrimidine-containing compound transmembrane transport (GO:0072531)4.89319467
27spermatid nucleus differentiation (GO:0007289)4.79901197
28gamete generation (GO:0007276)4.77505308
29calcium ion-dependent exocytosis (GO:0017156)4.76477310
30organic cation transport (GO:0015695)4.75372501
31one-carbon compound transport (GO:0019755)4.68368380
32cell recognition (GO:0008037)4.67172570
33regulation of interleukin-5 production (GO:0032674)4.66278278
34cellular process involved in reproduction in multicellular organism (GO:0022412)4.66165418
35male meiosis I (GO:0007141)4.61959032
36DNA methylation involved in gamete generation (GO:0043046)4.58706007
37tolerance induction (GO:0002507)4.49681225
38centriole assembly (GO:0098534)4.49600902
39germ cell development (GO:0007281)4.46978681
40negative regulation of T cell differentiation in thymus (GO:0033085)4.45593237
41lung epithelium development (GO:0060428)4.35752937
42regulation of interleukin-13 production (GO:0032656)4.27814971
43regulation of microtubule-based movement (GO:0060632)4.26507570
44glomerular epithelial cell development (GO:0072310)4.25419633
45cilium morphogenesis (GO:0060271)4.24240358
46microtubule severing (GO:0051013)4.24199991
47lateral ventricle development (GO:0021670)4.20690570
48negative regulation of immunoglobulin mediated immune response (GO:0002890)4.17566364
49negative regulation of B cell mediated immunity (GO:0002713)4.17566364
50protein localization to cilium (GO:0061512)4.14671705
51establishment of apical/basal cell polarity (GO:0035089)4.14276582
52negative regulation of humoral immune response (GO:0002921)4.09580816
53ethanol oxidation (GO:0006069)4.08109008
54nucleoside diphosphate phosphorylation (GO:0006165)4.04934051
55left/right axis specification (GO:0070986)4.03640573
56chromosome organization involved in meiosis (GO:0070192)4.03628284
57cilium organization (GO:0044782)3.99846032
58intraciliary transport (GO:0042073)3.99135709
59meiotic nuclear division (GO:0007126)3.93688570
60regulation of germinal center formation (GO:0002634)3.93510622
61cytoplasmic microtubule organization (GO:0031122)3.92104199
62regulation of inclusion body assembly (GO:0090083)3.90470696
63cilium assembly (GO:0042384)3.89171545
64terpenoid biosynthetic process (GO:0016114)3.89107945
65retinoic acid metabolic process (GO:0042573)3.88771646
66GTP biosynthetic process (GO:0006183)3.83644948
67left/right pattern formation (GO:0060972)3.78327992
68multicellular organismal reproductive process (GO:0048609)3.76185229
69establishment of monopolar cell polarity (GO:0061162)3.74297773
70establishment or maintenance of monopolar cell polarity (GO:0061339)3.74297773
71centriole replication (GO:0007099)3.70498900
72cellular component assembly involved in morphogenesis (GO:0010927)3.63600536
73negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.63402737
74meiosis I (GO:0007127)3.60339487
75positive regulation of tolerance induction (GO:0002645)3.51689150
76* microtubule-based movement (GO:0007018)3.50500194
77exogenous drug catabolic process (GO:0042738)3.39317197
78retinal cone cell development (GO:0046549)3.36850507
79UTP biosynthetic process (GO:0006228)3.31815843
80establishment of tissue polarity (GO:0007164)3.31512048
81establishment of planar polarity (GO:0001736)3.31512048
82determination of left/right symmetry (GO:0007368)3.30162069
83retinal rod cell development (GO:0046548)3.26886529
84determination of bilateral symmetry (GO:0009855)3.18373959
85meiotic cell cycle (GO:0051321)3.15919142
86O-glycan processing (GO:0016266)3.15867402
87specification of symmetry (GO:0009799)3.10955122
88alditol metabolic process (GO:0019400)3.06630987
89positive regulation of smoothened signaling pathway (GO:0045880)3.06093077
90multicellular organismal development (GO:0007275)3.01211994
91UTP metabolic process (GO:0046051)3.00386394
92primary alcohol metabolic process (GO:0034308)2.99826038
93monoubiquitinated protein deubiquitination (GO:0035520)2.99591548
94protein polyglutamylation (GO:0018095)2.99425808
95glycerol ether metabolic process (GO:0006662)2.97772686
96* microtubule-based process (GO:0007017)2.93640553
97glycerol metabolic process (GO:0006071)2.90445102
98retinol metabolic process (GO:0042572)2.90015645
99photoreceptor cell maintenance (GO:0045494)2.88777625
100genitalia morphogenesis (GO:0035112)2.84698482
101glutathione derivative metabolic process (GO:1901685)2.83391413
102glutathione derivative biosynthetic process (GO:1901687)2.83391413
103negative regulation of organelle assembly (GO:1902116)2.81812410
104regulation of microtubule depolymerization (GO:0031114)2.81247755
105seminiferous tubule development (GO:0072520)2.80313051
106carnitine transport (GO:0015879)2.79492274
107amino-acid betaine transport (GO:0015838)2.79492274
108hydrogen peroxide biosynthetic process (GO:0050665)2.78247441
109microtubule bundle formation (GO:0001578)2.75723281
110drug catabolic process (GO:0042737)2.74924696
111regulation of centriole replication (GO:0046599)2.74852994
112ether metabolic process (GO:0018904)2.73685380
113microtubule polymerization or depolymerization (GO:0031109)2.73216732
114carnitine metabolic process (GO:0009437)2.71500002
115chaperone-mediated protein complex assembly (GO:0051131)2.69830529
116carnitine transmembrane transport (GO:1902603)2.69703407
117phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.69060908
118lateral sprouting from an epithelium (GO:0060601)2.68714279
119aldehyde catabolic process (GO:0046185)2.67493751
120regulation of meiosis I (GO:0060631)2.58762668
121protein K11-linked deubiquitination (GO:0035871)2.57174393
122phosphatidylcholine biosynthetic process (GO:0006656)2.56614033
123phosphatidylethanolamine biosynthetic process (GO:0006646)2.55615972
124single strand break repair (GO:0000012)2.55207956
125macroautophagy (GO:0016236)2.54591344
126excretion (GO:0007588)2.54215012
127regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.53916126
128regulation of podosome assembly (GO:0071801)2.53443972
129single-organism membrane fusion (GO:0044801)2.52725406
130cell projection assembly (GO:0030031)2.52374133
131regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.52295538
132synapsis (GO:0007129)2.51297369
133regulation of tolerance induction (GO:0002643)2.50374236
134multicellular organismal water homeostasis (GO:0050891)2.49938555
135apical protein localization (GO:0045176)2.49920659
136polyol catabolic process (GO:0046174)2.49377041
137regulation of protein polyubiquitination (GO:1902914)2.45461055
138reactive oxygen species biosynthetic process (GO:1903409)2.45448840
139nonmotile primary cilium assembly (GO:0035058)2.44785757
140heart looping (GO:0001947)2.44418596
141pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.42116340
142organelle assembly (GO:0070925)2.41435596
143gene silencing by RNA (GO:0031047)2.41182120
144protein O-linked glycosylation (GO:0006493)2.39546417
145regulation of cilium assembly (GO:1902017)2.39144009
146iron ion import (GO:0097286)2.38456017
147smoothened signaling pathway (GO:0007224)2.35628694
148guanosine-containing compound biosynthetic process (GO:1901070)2.35151779
149peptidyl-threonine dephosphorylation (GO:0035970)2.34128452
150lactate metabolic process (GO:0006089)2.31076967
151fusion of sperm to egg plasma membrane (GO:0007342)15.1046856
152cell wall macromolecule metabolic process (GO:0044036)13.9837785
153cell wall macromolecule catabolic process (GO:0016998)13.9837785
154* cilium or flagellum-dependent cell motility (GO:0001539)13.6683410
155multicellular organism reproduction (GO:0032504)12.2693696
156axonemal dynein complex assembly (GO:0070286)12.1226631
157plasma membrane fusion (GO:0045026)11.6015998
158motile cilium assembly (GO:0044458)10.8062055
159cilium movement (GO:0003341)10.8017499
160acrosome assembly (GO:0001675)10.7906105
161epithelial cilium movement (GO:0003351)10.7496524
162sperm motility (GO:0030317)10.5610400
163sperm-egg recognition (GO:0035036)10.4096541

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse7.34945462
2BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.62388526
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.10864308
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.50363285
5DROSHA_22980978_ChIP-Seq_HELA_Human3.49583500
6FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human3.20282302
7EZH2_22144423_ChIP-Seq_EOC_Human3.09988795
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.75252396
9PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.60330170
10CBX2_27304074_Chip-Seq_ESCs_Mouse2.53235824
11FLI1_27457419_Chip-Seq_LIVER_Mouse2.49079358
12ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.37877279
13PCGF2_27294783_Chip-Seq_ESCs_Mouse2.34280943
14TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.32697977
15CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.27375615
16ZFP57_27257070_Chip-Seq_ESCs_Mouse2.07502951
17AHR_22903824_ChIP-Seq_MCF-7_Human2.05734152
18PIAS1_25552417_ChIP-Seq_VCAP_Human2.03266869
19EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.00360820
20ESR1_20079471_ChIP-ChIP_T-47D_Human1.99535620
21KAP1_22055183_ChIP-Seq_ESCs_Mouse1.94041181
22PCGF2_27294783_Chip-Seq_NPCs_Mouse1.91987374
23GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.88093426
24SUZ12_27294783_Chip-Seq_NPCs_Mouse1.87181270
25FOXM1_26456572_ChIP-Seq_MCF-7_Human1.83884193
26ARNT_22903824_ChIP-Seq_MCF-7_Human1.81867910
27STAT6_21828071_ChIP-Seq_BEAS2B_Human1.80217694
28NFE2_27457419_Chip-Seq_LIVER_Mouse1.79698398
29KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.77551726
30TAL1_26923725_Chip-Seq_HPCs_Mouse1.75900282
31NR3C1_21868756_ChIP-Seq_MCF10A_Human1.75333827
32TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.73797225
33KDM2B_26808549_Chip-Seq_REH_Human1.71026910
34FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.69839174
35TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.68293054
36TP63_23658742_ChIP-Seq_EP156T_Human1.66873218
37ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.64677558
38ZNF274_21170338_ChIP-Seq_K562_Hela1.63080461
39AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.61695127
40MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.60560942
41STAT1_20625510_ChIP-Seq_HELA_Human1.59777612
42FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.59401513
43RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.58744133
44VDR_22108803_ChIP-Seq_LS180_Human1.57949929
45WDR5_24793694_ChIP-Seq_LNCAP_Human1.57319784
46STAT1_17558387_ChIP-Seq_HELA_Human1.57173268
47ZNF217_24962896_ChIP-Seq_MCF-7_Human1.56504542
48ETV1_20927104_ChIP-Seq_GIST48_Human1.55472234
49EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.54303877
50NANOG_18555785_Chip-Seq_ESCs_Mouse1.53360133
51EZH2_27294783_Chip-Seq_NPCs_Mouse1.53162007
52SMRT_27268052_Chip-Seq_Bcells_Human1.52103815
53CRX_20693478_ChIP-Seq_RETINA_Mouse1.50246117
54ELK4_26923725_Chip-Seq_MESODERM_Mouse1.46095519
55TP53_18474530_ChIP-ChIP_U2OS_Human1.45849768
56CMYC_18555785_Chip-Seq_ESCs_Mouse1.43714991
57PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.43102893
58CTBP2_25329375_ChIP-Seq_LNCAP_Human1.42873748
59P53_22387025_ChIP-Seq_ESCs_Mouse1.42149967
60TDRD3_21172665_ChIP-Seq_MCF-7_Human1.41468953
61TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.41337921
62OCT4_18555785_Chip-Seq_ESCs_Mouse1.41219972
63P300_18555785_Chip-Seq_ESCs_Mouse1.39932418
64TRIM28_21343339_ChIP-Seq_HEK293_Human1.39585308
65PHF8_20622853_ChIP-Seq_HELA_Human1.38391816
66RNF2_27304074_Chip-Seq_NSC_Mouse1.38281053
67EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.38260394
68RUNX1_27514584_Chip-Seq_MCF-7_Human1.37832926
69CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.37702758
70SMC4_20622854_ChIP-Seq_HELA_Human1.37218915
71TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36687009
72GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.35156044
73GATA1_26923725_Chip-Seq_HPCs_Mouse1.34845095
74TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.34477006
75FLI1_21867929_ChIP-Seq_TH2_Mouse1.34386402
76SUZ12_18555785_Chip-Seq_ESCs_Mouse1.34207960
77HNFA_21074721_ChIP-Seq_CACO-2_Human1.34205342
78CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.33961480
79CBP_20019798_ChIP-Seq_JUKART_Human1.32985727
80IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.32985727
81MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.32148753
82AR_21572438_ChIP-Seq_LNCaP_Human1.32124053
83FOXA1_25552417_ChIP-Seq_VCAP_Human1.32123351
84ESRRB_18555785_Chip-Seq_ESCs_Mouse1.31524229
85STAT3_18555785_Chip-Seq_ESCs_Mouse1.30680445
86STAT3_23295773_ChIP-Seq_U87_Human1.30502304
87KLF5_25053715_ChIP-Seq_YYC3_Human1.30191651
88RBPJ_21746931_ChIP-Seq_IB4_Human1.30183786
89OCT4_21477851_ChIP-Seq_ESCs_Mouse1.29356096
90CTNNB1_20460455_ChIP-Seq_HCT116_Human1.29125412
91KLF4_18555785_Chip-Seq_ESCs_Mouse1.28374393
92SOX2_27498859_Chip-Seq_STOMACH_Mouse1.26954542
93E2F1_18555785_Chip-Seq_ESCs_Mouse1.26742539
94TAF15_26573619_Chip-Seq_HEK293_Human1.26431746
95SOX2_18555785_Chip-Seq_ESCs_Mouse1.25371344
96ESR1_21235772_ChIP-Seq_MCF-7_Human1.24580482
97GF1_26923725_Chip-Seq_HPCs_Mouse1.22633823
98* TP63_22573176_ChIP-Seq_HFKS_Human1.22500607
99CBX2_22325352_ChIP-Seq_293T-Rex_Human1.21718596
100CTCF_18555785_Chip-Seq_ESCs_Mouse1.21049800
101PU1_27457419_Chip-Seq_LIVER_Mouse1.20875752
102PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.18455340
103RAD21_21589869_ChIP-Seq_MESCs_Mouse1.18069913
104CDX2_19796622_ChIP-Seq_MESCs_Mouse1.17796122
105REST_21632747_ChIP-Seq_MESCs_Mouse1.16593312
106NFYA_21822215_ChIP-Seq_K562_Human1.16410654
107AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.16234204
108TP53_16413492_ChIP-PET_HCT116_Human1.16221878
109ZFX_18555785_Chip-Seq_ESCs_Mouse1.16029557
110TCF4_22108803_ChIP-Seq_LS180_Human1.15666999
111SMAD3_21741376_ChIP-Seq_EPCs_Human1.15517729
112CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.15392046
113RUNX1_27457419_Chip-Seq_LIVER_Mouse1.14024871
114CEBPB_22108803_ChIP-Seq_LS180_Human1.13801316
115GATA4_25053715_ChIP-Seq_YYC3_Human1.13587624
116ER_23166858_ChIP-Seq_MCF-7_Human1.13553276
117SMAD3_21741376_ChIP-Seq_HESCs_Human1.13476009
118SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.13218275
119CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.13132171
120GATA6_21074721_ChIP-Seq_CACO-2_Human1.11978806
121LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.11828890
122SOX9_24532713_ChIP-Seq_HFSC_Mouse1.11446794
123FOXA1_25329375_ChIP-Seq_VCAP_Human1.11286198
124FOXA1_27270436_Chip-Seq_PROSTATE_Human1.11286198
125PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.10919752
126SMAD4_21799915_ChIP-Seq_A2780_Human1.10828114
127SMAD1_18555785_Chip-Seq_ESCs_Mouse1.10310517
128ESR2_21235772_ChIP-Seq_MCF-7_Human1.09334664
129STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.08751430
130TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.08262303
131NMYC_18555785_Chip-Seq_ESCs_Mouse1.08165929
132GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.07001052
133AR_20517297_ChIP-Seq_VCAP_Human1.06904384
134UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.06896544
135SOX2_22085726_ChIP-Seq_NPCs_Mouse1.05665535
136SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.05519228
137GATA3_21867929_ChIP-Seq_CD8_Mouse1.05452105
138EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.04856045
139P63_26484246_Chip-Seq_KERATINOCYTES_Human1.04530688
140SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.04522432
141SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.04433390
142POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.04061490
143TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04061490
144ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.03852740
145GATA3_21867929_ChIP-Seq_TH1_Mouse1.02742169
146CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.02380834
147FUS_26573619_Chip-Seq_HEK293_Human1.02063473
148CTCF_20526341_ChIP-Seq_ESCs_Human1.01923007
149GF1B_26923725_Chip-Seq_HPCs_Mouse1.01886103
150EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.01767080
151FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.01738015
152CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.01681884
153PRDM14_20953172_ChIP-Seq_ESCs_Human1.01134165
154RUNX2_22187159_ChIP-Seq_PCA_Human1.00829914
155SMAD4_21741376_ChIP-Seq_EPCs_Human1.00626717
156YY1_22570637_ChIP-Seq_MALME-3M_Human0.99659581
157CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.99477191
158CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99310988
159* TCF4_23295773_ChIP-Seq_U87_Human0.99160430
160FOXO3_23340844_ChIP-Seq_DLD1_Human0.97490595
161OCT4_20526341_ChIP-Seq_ESCs_Human0.97354272
162SMAD4_21741376_ChIP-Seq_HESCs_Human0.97252177
163POU3F2_20337985_ChIP-ChIP_501MEL_Human0.96682765
164TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.96611501
165CDX2_22108803_ChIP-Seq_LS180_Human0.95948582
166NFYB_21822215_ChIP-Seq_K562_Human0.95791327
167BCAT_22108803_ChIP-Seq_LS180_Human0.95674390
168TOP2B_26459242_ChIP-Seq_MCF-7_Human0.92866298
169PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.92155822
170TBL1_22424771_ChIP-Seq_293T_Human0.91030732
171P53_21459846_ChIP-Seq_SAOS-2_Human0.90936778
172CTBP1_25329375_ChIP-Seq_LNCAP_Human0.88262963
173STAT3_18555785_ChIP-Seq_MESCs_Mouse0.88079009

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008875_abnormal_xenobiotic_pharmacok6.79346899
2MP0003698_abnormal_male_reproductive5.53667235
3MP0001929_abnormal_gametogenesis4.84820667
4MP0002653_abnormal_ependyma_morphology4.76038692
5MP0008877_abnormal_DNA_methylation3.99013835
6MP0004043_abnormal_pH_regulation3.93751642
7MP0005623_abnormal_meninges_morphology3.68724093
8MP0002277_abnormal_respiratory_mucosa3.66796353
9MP0008789_abnormal_olfactory_epithelium3.34636475
10MP0002210_abnormal_sex_determination3.22850666
11MP0002161_abnormal_fertility/fecundity2.96468299
12MP0001145_abnormal_male_reproductive2.70743253
13MP0005670_abnormal_white_adipose2.58867716
14MP0000653_abnormal_sex_gland2.40681767
15MP0010678_abnormal_skin_adnexa2.35715024
16MP0005394_taste/olfaction_phenotype2.22515821
17MP0005499_abnormal_olfactory_system2.22515821
18MP0002102_abnormal_ear_morphology2.20871749
19MP0000566_synostosis2.04331254
20MP0002160_abnormal_reproductive_system2.04310357
21MP0005410_abnormal_fertilization13.8996228
22MP0009046_muscle_twitch1.91512001
23MP0002928_abnormal_bile_duct1.87910087
24MP0000678_abnormal_parathyroid_gland1.73871133
25MP0005083_abnormal_biliary_tract1.70632281
26MP0005647_abnormal_sex_gland1.69778411
27MP0008995_early_reproductive_senescence1.67495674
28MP0003656_abnormal_erythrocyte_physiolo1.65896769
29MP0003045_fibrosis1.64907428
30MP0002282_abnormal_trachea_morphology1.54328704
31MP0003718_maternal_effect1.45962973
32MP0002876_abnormal_thyroid_physiology1.43709438
33MP0002909_abnormal_adrenal_gland1.41640417
34MP0001765_abnormal_ion_homeostasis1.34642545
35MP0001346_abnormal_lacrimal_gland1.27478747
36MP0008058_abnormal_DNA_repair1.25391907
37MP0004233_abnormal_muscle_weight1.23159096
38MP0001984_abnormal_olfaction1.20733817
39MP0003136_yellow_coat_color1.16359864
40MP0001485_abnormal_pinna_reflex1.15267045
41MP0002735_abnormal_chemical_nociception1.10271540
42MP0002734_abnormal_mechanical_nocicepti1.06114578
43MP0002234_abnormal_pharynx_morphology1.04318926
44MP0005423_abnormal_somatic_nervous1.04268715
45MP0005389_reproductive_system_phenotype1.01917145
46MP0005310_abnormal_salivary_gland1.01391204
47MP0010234_abnormal_vibrissa_follicle1.00998842
48MP0005167_abnormal_blood-brain_barrier0.99832933
49MP0003950_abnormal_plasma_membrane0.99309849
50MP0005248_abnormal_Harderian_gland0.98013709
51MP0002233_abnormal_nose_morphology0.97252025
52MP0002638_abnormal_pupillary_reflex0.94568541
53MP0002249_abnormal_larynx_morphology0.94144745
54MP0008004_abnormal_stomach_pH0.93930839
55MP0000681_abnormal_thyroid_gland0.93228836
56MP0000465_gastrointestinal_hemorrhage0.92992195
57MP0005551_abnormal_eye_electrophysiolog0.89201730
58MP0005646_abnormal_pituitary_gland0.85897942
59MP0010155_abnormal_intestine_physiology0.85197056
60MP0002168_other_aberrant_phenotype0.83635744
61MP0005085_abnormal_gallbladder_physiolo0.83412063
62MP0001986_abnormal_taste_sensitivity0.82846062
63MP0009643_abnormal_urine_homeostasis0.81838984
64MP0003195_calcinosis0.81521681
65MP0005165_increased_susceptibility_to0.78084333
66MP0005365_abnormal_bile_salt0.77392785
67MP0002136_abnormal_kidney_physiology0.77080445
68MP0005388_respiratory_system_phenotype0.74900385
69MP0002133_abnormal_respiratory_system0.74900385
70MP0003279_aneurysm0.74712781
71MP0001958_emphysema0.73930105
72MP0002229_neurodegeneration0.73388669
73MP0005408_hypopigmentation0.72523522
74MP0003890_abnormal_embryonic-extraembry0.72237245
75MP0001293_anophthalmia0.70395217
76MP0004133_heterotaxia0.69282018
77MP0001664_abnormal_digestion0.68636709
78MP0005220_abnormal_exocrine_pancreas0.67829035
79MP0010030_abnormal_orbit_morphology0.67610823
80MP0010368_abnormal_lymphatic_system0.67435326
81MP0004742_abnormal_vestibular_system0.65951787
82MP0000631_abnormal_neuroendocrine_gland0.64395434
83MP0005503_abnormal_tendon_morphology0.64017680
84MP0003690_abnormal_glial_cell0.61015409
85MP0004264_abnormal_extraembryonic_tissu0.60898631
86MP0005636_abnormal_mineral_homeostasis0.60116088
87MP0005253_abnormal_eye_physiology0.60111285
88MP0005377_hearing/vestibular/ear_phenot0.59133501
89MP0003878_abnormal_ear_physiology0.59133501
90MP0005409_darkened_coat_color0.59084403
91MP0005164_abnormal_response_to0.59075542
92MP0002098_abnormal_vibrissa_morphology0.58917314
93MP0009115_abnormal_fat_cell0.56791766
94MP0001270_distended_abdomen0.56354046
95MP0002557_abnormal_social/conspecific_i0.56161021
96MP0009379_abnormal_foot_pigmentation0.54446608
97MP0004782_abnormal_surfactant_physiolog0.54350473
98MP0001944_abnormal_pancreas_morphology0.53916191
99MP0003633_abnormal_nervous_system0.53879833
100MP0008872_abnormal_physiological_respon0.53698715
101MP0001970_abnormal_pain_threshold0.52910985
102MP0003937_abnormal_limbs/digits/tail_de0.52721125
103MP0003252_abnormal_bile_duct0.52057230
104MP0009765_abnormal_xenobiotic_induced0.51827797
105MP0003646_muscle_fatigue0.51158361
106MP0000427_abnormal_hair_cycle0.49684676
107MP0000383_abnormal_hair_follicle0.46807325
108MP0004883_abnormal_blood_vessel0.46695994
109MP0001661_extended_life_span0.45632688
110MP0001324_abnormal_eye_pigmentation0.45280587
111MP0003699_abnormal_female_reproductive0.45049345
112MP0000026_abnormal_inner_ear0.43446705
113MP0004272_abnormal_basement_membrane0.42951099
114MP0001119_abnormal_female_reproductive0.42230520
115MP0001963_abnormal_hearing_physiology0.41846238
116MP0002084_abnormal_developmental_patter0.41760868
117MP0009703_decreased_birth_body0.40770834
118MP0003786_premature_aging0.40481348
119MP0002116_abnormal_craniofacial_bone0.40012107
120MP0002269_muscular_atrophy0.39184186
121MP0004019_abnormal_vitamin_homeostasis0.39025387
122MP0002135_abnormal_kidney_morphology0.38936986
123MP0001188_hyperpigmentation0.38822943
124MP0001666_abnormal_nutrient_absorption0.38548950
125MP0001440_abnormal_grooming_behavior0.38531096
126MP0005666_abnormal_adipose_tissue0.38358591
127MP0001502_abnormal_circadian_rhythm0.38298572
128MP0002971_abnormal_brown_adipose0.38128992
129MP0003879_abnormal_hair_cell0.37928004
130MP0001177_atelectasis0.37334711
131MP0002752_abnormal_somatic_nervous0.37275753
132MP0001851_eye_inflammation0.36190379
133MP0001968_abnormal_touch/_nociception0.35930121
134MP0000432_abnormal_head_morphology0.35727846
135MP0002405_respiratory_system_inflammati0.33566207
136MP0003115_abnormal_respiratory_system0.33370478
137MP0009780_abnormal_chondrocyte_physiolo0.32592644
138MP0003631_nervous_system_phenotype0.32412308
139MP0000647_abnormal_sebaceous_gland0.31771320
140MP0002132_abnormal_respiratory_system0.31756609
141MP0001486_abnormal_startle_reflex0.31702493
142MP0002152_abnormal_brain_morphology0.31581399
143MP0003011_delayed_dark_adaptation0.31522233
144MP0009250_abnormal_appendicular_skeleto0.31125550
145MP0005391_vision/eye_phenotype0.31088795
146MP0008057_abnormal_DNA_replication0.30982704
147MP0009384_cardiac_valve_regurgitation0.29043660
148MP0001873_stomach_inflammation0.28843278
149MP0009745_abnormal_behavioral_response0.28271410
150MP0003283_abnormal_digestive_organ0.28254503
151MP0004134_abnormal_chest_morphology0.27992674
152MP0003942_abnormal_urinary_system0.27370726
153MP0005195_abnormal_posterior_eye0.26902965
154MP0002139_abnormal_hepatobiliary_system0.26455202
155MP0005395_other_phenotype0.26439408
156MP0003861_abnormal_nervous_system0.24287146
157MP0000579_abnormal_nail_morphology0.24127216

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium morphology (HP:0005938)9.32517353
2Abnormal respiratory epithelium morphology (HP:0012253)9.32517353
3Abnormal ciliary motility (HP:0012262)9.22483298
4Rhinitis (HP:0012384)8.34888516
5Chronic bronchitis (HP:0004469)6.99364681
6Nasal polyposis (HP:0100582)5.90719471
7Infertility (HP:0000789)5.11131378
8Abnormality of the nasal mucosa (HP:0000433)5.02586906
9Bronchiectasis (HP:0002110)5.02027282
10Bronchitis (HP:0012387)4.15857792
11Nephronophthisis (HP:0000090)3.83514339
12Medial flaring of the eyebrow (HP:0010747)3.75778887
13Recurrent sinusitis (HP:0011108)3.70674073
14Male infertility (HP:0003251)3.62387537
15Gait imbalance (HP:0002141)3.19227829
16Congenital primary aphakia (HP:0007707)3.18353013
17Tubulointerstitial nephritis (HP:0001970)3.09425323
18Abnormality of the renal medulla (HP:0100957)3.01999197
19Recurrent otitis media (HP:0000403)2.94169456
20Hyperactive renin-angiotensin system (HP:0000841)2.82813302
21Nephrogenic diabetes insipidus (HP:0009806)2.80569717
22Abnormality of midbrain morphology (HP:0002418)2.79067131
23Molar tooth sign on MRI (HP:0002419)2.79067131
24Atelectasis (HP:0100750)2.74889248
25Pancreatic fibrosis (HP:0100732)2.65773742
26Chronic sinusitis (HP:0011109)2.63640885
27True hermaphroditism (HP:0010459)2.59311742
28Cystic liver disease (HP:0006706)2.56764129
29Abnormal spermatogenesis (HP:0008669)2.41731505
30Genital tract atresia (HP:0001827)2.41071979
31Tubulointerstitial abnormality (HP:0001969)2.37951267
32Vaginal atresia (HP:0000148)2.36990513
33Poor coordination (HP:0002370)2.33837755
34Postaxial foot polydactyly (HP:0001830)2.30834984
35Recurrent bronchitis (HP:0002837)2.26853199
36Tubular atrophy (HP:0000092)2.22556533
37Congenital hepatic fibrosis (HP:0002612)2.20330055
38Abnormal biliary tract physiology (HP:0012439)2.17666350
39Bile duct proliferation (HP:0001408)2.17666350
40Azoospermia (HP:0000027)2.14067704
41Stage 5 chronic kidney disease (HP:0003774)2.12285053
42Aplasia/Hypoplasia of the lens (HP:0008063)2.09219113
43Supernumerary spleens (HP:0009799)2.03770242
44Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.9159376
45Absent/shortened dynein arms (HP:0200106)11.5667640
46Dynein arm defect of respiratory motile cilia (HP:0012255)11.5667640
47Abnormal respiratory motile cilium physiology (HP:0012261)10.2011058
48Abnormality of the renal cortex (HP:0011035)1.98168229
49Decreased circulating renin level (HP:0003351)1.95011847
50Aplasia/Hypoplasia of the tongue (HP:0010295)1.92337789
51Fibular hypoplasia (HP:0003038)1.88916158
52Pancreatic cysts (HP:0001737)1.88485709
53Postaxial hand polydactyly (HP:0001162)1.85569776
54Tubulointerstitial fibrosis (HP:0005576)1.83821073
55Median cleft lip (HP:0000161)1.81134550
56Absent frontal sinuses (HP:0002688)1.79049592
57Abnormality of the dental root (HP:0006486)1.78001161
58Taurodontia (HP:0000679)1.78001161
59Abnormality of permanent molar morphology (HP:0011071)1.78001161
60Aplasia/Hypoplasia of the spleen (HP:0010451)1.77608434
61Asplenia (HP:0001746)1.77337815
62Sclerocornea (HP:0000647)1.76996834
63Abnormality of molar morphology (HP:0011070)1.74857376
64Abnormality of molar (HP:0011077)1.74857376
65Absent rod-and cone-mediated responses on ERG (HP:0007688)1.74625123
66Hyperkalemia (HP:0002153)1.73637091
67Furrowed tongue (HP:0000221)1.70096075
68Facial cleft (HP:0002006)1.69675716
69Renal salt wasting (HP:0000127)1.65972176
70Male pseudohermaphroditism (HP:0000037)1.65682227
71Oculomotor apraxia (HP:0000657)1.65350728
72Tongue fasciculations (HP:0001308)1.64215636
73Occipital encephalocele (HP:0002085)1.62062322
74Impulsivity (HP:0100710)1.60553284
75Abnormality of the dental pulp (HP:0006479)1.60293486
76Muscle fibrillation (HP:0010546)1.55767113
77Chronic hepatic failure (HP:0100626)1.53519773
78Abnormality of dentin (HP:0010299)1.52317895
79Abnormality of saccadic eye movements (HP:0000570)1.50255273
80Hyperaldosteronism (HP:0000859)1.46831419
81Polydipsia (HP:0001959)1.45205227
82Abnormal drinking behavior (HP:0030082)1.45205227
83J-shaped sella turcica (HP:0002680)1.43415828
84Abnormality of renal excretion (HP:0011036)1.42318909
85Cone-rod dystrophy (HP:0000548)1.40891338
86Renal dysplasia (HP:0000110)1.38781834
87Abnormality of renin-angiotensin system (HP:0000847)1.38657365
88Hypodontia (HP:0000668)1.37904975
89Renovascular hypertension (HP:0100817)1.37684906
90Short ribs (HP:0000773)1.37043853
91Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.36444022
92Specific learning disability (HP:0001328)1.36266080
93Nephropathy (HP:0000112)1.32716373
94Gonadotropin excess (HP:0000837)1.32702909
95Anencephaly (HP:0002323)1.32406326
96Broad foot (HP:0001769)1.32226287
97Abnormality of chloride homeostasis (HP:0011422)1.29366121
98Abnormal rod and cone electroretinograms (HP:0008323)1.28834902
99Microglossia (HP:0000171)1.28827221
100Preaxial hand polydactyly (HP:0001177)1.28333821
101Chronic otitis media (HP:0000389)1.28274395
102Polycystic kidney dysplasia (HP:0000113)1.27785144
103Bell-shaped thorax (HP:0001591)1.26300160
104Decreased central vision (HP:0007663)1.25487142
105Hypoplasia of the capital femoral epiphysis (HP:0003090)1.25479661
106Abnormality of ocular smooth pursuit (HP:0000617)1.22567962
107Hypokalemic alkalosis (HP:0001949)1.20615359
108Slow saccadic eye movements (HP:0000514)1.19309836
109Dental crowding (HP:0000678)1.17697050
110Aplasia/Hypoplasia of the fibula (HP:0006492)1.17326455
111Impaired smooth pursuit (HP:0007772)1.16453492
112Breast carcinoma (HP:0003002)1.15964343
113Abnormality of macular pigmentation (HP:0008002)1.15673848
114Polycystic ovaries (HP:0000147)1.14529274
115Retinitis pigmentosa (HP:0000510)1.14250885
116Astigmatism (HP:0000483)1.14048333
117Short thorax (HP:0010306)1.13791358
118Lip pit (HP:0100267)1.13021396
119Glucose intolerance (HP:0000833)1.12064230
120Heterotopia (HP:0002282)1.11616243
121Amyotrophic lateral sclerosis (HP:0007354)1.11566397
122Abnormality of the frontal sinuses (HP:0002687)1.11144697
123Hand muscle atrophy (HP:0009130)1.07438456
124Hyponatremia (HP:0002902)1.06146138
125Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.05898819
126Fetal akinesia sequence (HP:0001989)1.05648335
127Bifid scrotum (HP:0000048)1.03563270
128Absent speech (HP:0001344)1.00250647
129Aplasia of the musculature (HP:0100854)0.97455570
130Bony spicule pigmentary retinopathy (HP:0007737)0.95298894
131Narrow forehead (HP:0000341)0.95234276

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK38.34820874
2PDK48.34820874
3MST45.98104518
4PDK25.40651155
5EPHA24.35207781
6TESK13.50851472
7PRKD33.31905390
8PNCK2.91570630
9STK392.56347332
10ICK2.56041845
11WNK42.50311413
12MAPKAPK32.46877602
13PTK2B2.34887487
14NME12.28042330
15ZAK2.20804495
16MAPK152.18594065
17FRK2.07584788
18STK241.94945578
19BCR1.91004179
20MAP3K21.88526043
21TTK1.54006028
22CAMK1G1.46672985
23LMTK21.44741384
24GRK11.32877504
25IRAK11.28900656
26PRKCI1.21468313
27TLK11.19730548
28MAP3K31.15906812
29WNK11.14903175
30STK381.10396275
31SMG11.09862508
32MST1R1.07165583
33MAP3K71.04286724
34CDK121.04199077
35TRPM71.01942518
36PLK40.98335571
37NEK20.97954426
38MAP3K40.92340493
39CHEK20.91736765
40INSRR0.88612831
41LATS10.86484533
42PDK10.85797901
43STK30.80380593
44DYRK1B0.79356171
45LRRK20.78371412
46EPHA30.77661648
47ADRBK20.72256336
48TYRO30.72076711
49PRKCH0.71534472
50TIE10.69909952
51ERBB30.67891486
52NLK0.67735401
53NEK60.66956631
54MET0.66242510
55ERBB20.63810723
56RIPK10.63771390
57PKN10.62706245
58CAMK1D0.59444418
59MAP4K20.59168359
60ACVR1B0.52837552
61AURKA0.52268947
62NTRK20.51045235
63SGK10.49318655
64MAP3K120.48038992
65IRAK20.47795295
66FER0.47670874
67MAPK130.47084914
68MUSK0.45403975
69PAK20.45207907
70STK160.44875091
71ADRBK10.42427440
72CAMKK20.41660328
73PINK10.41096547
74CDK190.40547610
75BMPR1B0.40544563
76MATK0.39805421
77STK38L0.38875426
78RIPK40.38528180
79WEE10.37691389
80CDK30.37569149
81PRKCD0.37234305
82CSK0.36392473
83ATM0.35864608
84PDPK10.35757192
85PRKCG0.35326288
86CHEK10.34862164
87BRSK20.34419408
88MAP2K60.32288887
89MAP2K20.30449481
90ATR0.29946098
91CAMKK10.29149058
92NEK90.28704827
93PRKG10.28518952
94PLK10.27083190
95YES10.26438912
96WNK30.26103265
97CDC42BPA0.25175579
98PRKCZ0.24980617
99GRK60.24680275
100DYRK30.24634729
101PRKAA20.24510462
102MAP2K40.23704395
103RPS6KB20.22757614
104ROCK10.22119175
105STK100.21954573
106MAP2K70.21730882
107PRKCE0.21571366
108AKT30.21317936
109MAPKAPK50.21213251
110MARK20.20946071
111EIF2AK20.20769377
112CAMK10.19954067
113MARK10.19833042
114HIPK20.19727739
115AKT20.19449677
116DYRK1A0.19264156
117SGK20.18103610
118CAMK2A0.17094430
119PRKACG0.16974892
120EPHB10.16653362
121PRKAA10.16524329
122PRKCQ0.16257371
123FGFR30.16200209
124EPHA40.15814009
125EEF2K0.15223787
126PAK10.15119775
127PRKG20.14929023
128CSNK1D0.14239030
129EGFR0.13815416
130TESK20.13417863
131PRKACA0.12878876
132CCNB10.12793520
133CASK0.12663444
134CSNK1E0.12609608
135DDR20.12223922
136GSK3A0.11987092
137MTOR0.11708800
138PRKCA0.11488243
139SRC0.11280382
140NTRK30.10980136
141STK110.10618290
142INSR0.10539149
143TBK10.10002957
144PRKDC0.09982115
145PASK0.08743024
146ABL10.08131613
147TGFBR20.07325684
148OXSR10.07319684
149OBSCN0.07221922
150CAMK2G0.06347994
151GSK3B0.06315137
152RPS6KA30.05703480

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007505.74653020
2Fatty acid biosynthesis_Homo sapiens_hsa000613.41622239
3Propanoate metabolism_Homo sapiens_hsa006403.09656474
4Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005123.00333451
5Caffeine metabolism_Homo sapiens_hsa002322.80231533
6Glycosaminoglycan degradation_Homo sapiens_hsa005312.66897599
7Pyruvate metabolism_Homo sapiens_hsa006202.61090116
8Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.60754024
9Fanconi anemia pathway_Homo sapiens_hsa034602.11220908
10Basal transcription factors_Homo sapiens_hsa030222.10988431
11Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.08068248
12Dorso-ventral axis formation_Homo sapiens_hsa043202.02463772
13PPAR signaling pathway_Homo sapiens_hsa033202.00034701
14Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.96254966
15Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.95058628
16Glucagon signaling pathway_Homo sapiens_hsa049221.88403625
17Glycerolipid metabolism_Homo sapiens_hsa005611.82179788
18Selenocompound metabolism_Homo sapiens_hsa004501.80162605
19Pentose phosphate pathway_Homo sapiens_hsa000301.68941722
20alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.67714675
21Mineral absorption_Homo sapiens_hsa049781.65204502
22Linoleic acid metabolism_Homo sapiens_hsa005911.59977147
23Taste transduction_Homo sapiens_hsa047421.54166797
24Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.47845918
25Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.46794156
26Renin secretion_Homo sapiens_hsa049241.40082933
27Carbohydrate digestion and absorption_Homo sapiens_hsa049731.37943748
28Huntingtons disease_Homo sapiens_hsa050161.31899387
29Glycerophospholipid metabolism_Homo sapiens_hsa005641.30782893
30Oocyte meiosis_Homo sapiens_hsa041141.26764132
31ABC transporters_Homo sapiens_hsa020101.26211764
32Ether lipid metabolism_Homo sapiens_hsa005651.19344955
33Phototransduction_Homo sapiens_hsa047441.18439274
34Peroxisome_Homo sapiens_hsa041461.18358204
35Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.17969426
36Amphetamine addiction_Homo sapiens_hsa050311.17589026
37Ovarian steroidogenesis_Homo sapiens_hsa049131.15260322
38Circadian rhythm_Homo sapiens_hsa047101.10148298
39Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.09815771
40Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.06156778
41Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.99548168
42Renin-angiotensin system_Homo sapiens_hsa046140.98199111
43Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.95819497
44Calcium signaling pathway_Homo sapiens_hsa040200.94995009
45Hedgehog signaling pathway_Homo sapiens_hsa043400.94653096
46Insulin secretion_Homo sapiens_hsa049110.94062601
47Glutathione metabolism_Homo sapiens_hsa004800.94044561
48Starch and sucrose metabolism_Homo sapiens_hsa005000.90270742
49Purine metabolism_Homo sapiens_hsa002300.90029406
50Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.89846313
51Fatty acid metabolism_Homo sapiens_hsa012120.88491576
52Primary bile acid biosynthesis_Homo sapiens_hsa001200.85208242
53Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.81542573
54Collecting duct acid secretion_Homo sapiens_hsa049660.81414115
55Salivary secretion_Homo sapiens_hsa049700.81130998
56Phosphatidylinositol signaling system_Homo sapiens_hsa040700.80396347
57Fatty acid degradation_Homo sapiens_hsa000710.79802327
58Protein digestion and absorption_Homo sapiens_hsa049740.79374317
59Chemical carcinogenesis_Homo sapiens_hsa052040.78823859
60Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.76698931
61Drug metabolism - other enzymes_Homo sapiens_hsa009830.75832303
62Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.73808533
63Cardiac muscle contraction_Homo sapiens_hsa042600.73757452
64Inositol phosphate metabolism_Homo sapiens_hsa005620.72494416
65Thyroid hormone synthesis_Homo sapiens_hsa049180.72073120
66Bile secretion_Homo sapiens_hsa049760.71568507
67Estrogen signaling pathway_Homo sapiens_hsa049150.70960637
68cAMP signaling pathway_Homo sapiens_hsa040240.70244081
69Tryptophan metabolism_Homo sapiens_hsa003800.68835222
70Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.68711974
71Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.68067817
72Butanoate metabolism_Homo sapiens_hsa006500.67176650
73Arachidonic acid metabolism_Homo sapiens_hsa005900.66271526
74Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.65437353
75Choline metabolism in cancer_Homo sapiens_hsa052310.64636751
76cGMP-PKG signaling pathway_Homo sapiens_hsa040220.64622866
77Circadian entrainment_Homo sapiens_hsa047130.64553543
78Pentose and glucuronate interconversions_Homo sapiens_hsa000400.64146766
79Retinol metabolism_Homo sapiens_hsa008300.63773909
80Steroid hormone biosynthesis_Homo sapiens_hsa001400.63138748
81Gastric acid secretion_Homo sapiens_hsa049710.62952002
82Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.62341645
83Basal cell carcinoma_Homo sapiens_hsa052170.62216206
84Vitamin digestion and absorption_Homo sapiens_hsa049770.59123514
85Carbon metabolism_Homo sapiens_hsa012000.58986061
86Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.57429784
87Nicotine addiction_Homo sapiens_hsa050330.51273585
88Serotonergic synapse_Homo sapiens_hsa047260.49142620
89Vascular smooth muscle contraction_Homo sapiens_hsa042700.46789586
90Adherens junction_Homo sapiens_hsa045200.46412320
91Phenylalanine metabolism_Homo sapiens_hsa003600.45819198
92Synaptic vesicle cycle_Homo sapiens_hsa047210.44466929
93Pancreatic secretion_Homo sapiens_hsa049720.44447477
94Hepatitis C_Homo sapiens_hsa051600.42888036
95Olfactory transduction_Homo sapiens_hsa047400.42280766
96Aldosterone synthesis and secretion_Homo sapiens_hsa049250.42045878
97Morphine addiction_Homo sapiens_hsa050320.41738318
98ECM-receptor interaction_Homo sapiens_hsa045120.41306620
99Regulation of autophagy_Homo sapiens_hsa041400.40988132
100Nitrogen metabolism_Homo sapiens_hsa009100.40336452
101Antigen processing and presentation_Homo sapiens_hsa046120.40015413
102Hematopoietic cell lineage_Homo sapiens_hsa046400.39247614
103Fructose and mannose metabolism_Homo sapiens_hsa000510.39095108
104Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.39045585
105Cocaine addiction_Homo sapiens_hsa050300.38781925
106Metabolic pathways_Homo sapiens_hsa011000.38689327
107Leukocyte transendothelial migration_Homo sapiens_hsa046700.38609581
108N-Glycan biosynthesis_Homo sapiens_hsa005100.37312968
109Cysteine and methionine metabolism_Homo sapiens_hsa002700.36824000
110beta-Alanine metabolism_Homo sapiens_hsa004100.36725724
111Histidine metabolism_Homo sapiens_hsa003400.36034639
112Adipocytokine signaling pathway_Homo sapiens_hsa049200.35810581
113Transcriptional misregulation in cancer_Homo sapiens_hsa052020.34936457
114Glutamatergic synapse_Homo sapiens_hsa047240.34685121
115Sphingolipid metabolism_Homo sapiens_hsa006000.34504613
116Wnt signaling pathway_Homo sapiens_hsa043100.34113427
117Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.33870078
118Long-term potentiation_Homo sapiens_hsa047200.33580896
119Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.32483410
120Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.32014167
121Tight junction_Homo sapiens_hsa045300.29677216
122Arginine and proline metabolism_Homo sapiens_hsa003300.29543587
123Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.28468493
124Notch signaling pathway_Homo sapiens_hsa043300.27937359
125Fat digestion and absorption_Homo sapiens_hsa049750.27887385
126Type I diabetes mellitus_Homo sapiens_hsa049400.26654862
127Intestinal immune network for IgA production_Homo sapiens_hsa046720.25508340
128Jak-STAT signaling pathway_Homo sapiens_hsa046300.25492590
129Tyrosine metabolism_Homo sapiens_hsa003500.25435322
130Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.24999549
131Complement and coagulation cascades_Homo sapiens_hsa046100.24455357
132mRNA surveillance pathway_Homo sapiens_hsa030150.24296721
133Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.23699301
134Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.23565232
135Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.22685503
136Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.21867290
137Cyanoamino acid metabolism_Homo sapiens_hsa004600.20823718
138Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.20592793
139Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.18869198
140Insulin resistance_Homo sapiens_hsa049310.17559297
141Graft-versus-host disease_Homo sapiens_hsa053320.16110736
142Allograft rejection_Homo sapiens_hsa053300.15904714
143Autoimmune thyroid disease_Homo sapiens_hsa053200.15242886
144Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.14162552
145Hippo signaling pathway_Homo sapiens_hsa043900.12149980
146Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.10888353
147Sphingolipid signaling pathway_Homo sapiens_hsa040710.10368795

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