DNAH5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a dynein protein, which is part of a microtubule-associated motor protein complex consisting of heavy, light, and intermediate chains. This protein is an axonemal heavy chain dynein. It functions as a force-generating protein with ATPase activity, whereby the release of ADP is thought to produce the force-producing power stroke. Mutations in this gene cause primary ciliary dyskinesia type 3, as well as Kartagener syndrome, which are both diseases due to ciliary defects. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* cilium movement (GO:0003341)9.20762358
2cilium or flagellum-dependent cell motility (GO:0001539)8.74530995
3axonemal dynein complex assembly (GO:0070286)8.65597999
4regulation of cilium movement (GO:0003352)8.54039070
5axoneme assembly (GO:0035082)7.49634405
6epithelial cilium movement (GO:0003351)6.45028164
7ventricular system development (GO:0021591)6.11433491
8epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.01609528
9primary alcohol catabolic process (GO:0034310)5.88052420
10vitamin transmembrane transport (GO:0035461)5.77947047
11diterpenoid biosynthetic process (GO:0016102)5.19163885
12regulation of microtubule-based movement (GO:0060632)4.95331621
13surfactant homeostasis (GO:0043129)4.94790670
14protein localization to cilium (GO:0061512)4.93615485
15regulation of interleukin-5 production (GO:0032674)4.64077980
16motile cilium assembly (GO:0044458)4.47426944
17chemical homeostasis within a tissue (GO:0048875)4.42501944
18centriole assembly (GO:0098534)4.39610798
19* left/right axis specification (GO:0070986)4.30233141
20pyrimidine-containing compound transmembrane transport (GO:0072531)4.27157035
21GTP biosynthetic process (GO:0006183)4.16970582
22vocalization behavior (GO:0071625)4.10573333
23regulation of interleukin-13 production (GO:0032656)3.99002992
24intraciliary transport (GO:0042073)3.98541758
25microtubule bundle formation (GO:0001578)3.91987937
26one-carbon compound transport (GO:0019755)3.90984137
27negative regulation of T cell differentiation in thymus (GO:0033085)3.84124369
28nucleoside diphosphate phosphorylation (GO:0006165)3.83866758
29tolerance induction (GO:0002507)3.77156566
30retinal rod cell development (GO:0046548)3.73340360
31cilium organization (GO:0044782)3.68706911
32cytoplasmic microtubule organization (GO:0031122)3.63761203
33cilium assembly (GO:0042384)3.55128836
34gas transport (GO:0015669)3.53401334
35terpenoid biosynthetic process (GO:0016114)3.50197932
36cilium morphogenesis (GO:0060271)3.48932769
37retinoic acid metabolic process (GO:0042573)3.47788794
38sperm capacitation (GO:0048240)3.47342072
39UTP biosynthetic process (GO:0006228)3.47060985
40regulation of germinal center formation (GO:0002634)3.45228507
41response to nitric oxide (GO:0071731)3.44996673
42UTP metabolic process (GO:0046051)3.43461659
43positive regulation of smoothened signaling pathway (GO:0045880)3.42439360
44determination of left/right symmetry (GO:0007368)3.40654937
45synaptic vesicle maturation (GO:0016188)3.36717939
46response to xenobiotic stimulus (GO:0009410)3.30335480
47determination of bilateral symmetry (GO:0009855)3.29355996
48iron ion import (GO:0097286)3.28431857
49negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.25291900
50establishment of planar polarity (GO:0001736)3.23056087
51establishment of tissue polarity (GO:0007164)3.23056087
52specification of symmetry (GO:0009799)3.22377251
53O-glycan processing (GO:0016266)3.21605260
54exogenous drug catabolic process (GO:0042738)3.19046819
55retinal cone cell development (GO:0046549)3.16989110
56lung epithelium development (GO:0060428)3.14720338
57positive regulation of tolerance induction (GO:0002645)3.09578515
58brain morphogenesis (GO:0048854)3.07880387
59negative regulation of humoral immune response (GO:0002921)3.03919572
60glomerular epithelial cell development (GO:0072310)2.96649644
61cellular component assembly involved in morphogenesis (GO:0010927)2.94580833
62microtubule depolymerization (GO:0007019)2.90042924
63smoothened signaling pathway (GO:0007224)2.88729294
64microtubule polymerization or depolymerization (GO:0031109)2.88612148
65regulation of glomerular filtration (GO:0003093)2.85271352
66photoreceptor cell maintenance (GO:0045494)2.85210859
67* microtubule-based process (GO:0007017)2.81035942
68primary alcohol metabolic process (GO:0034308)2.80592713
69L-ascorbic acid metabolic process (GO:0019852)2.79771962
70establishment or maintenance of monopolar cell polarity (GO:0061339)2.79653750
71establishment of monopolar cell polarity (GO:0061162)2.79653750
72neuron cell-cell adhesion (GO:0007158)2.79522335
73sodium ion homeostasis (GO:0055078)2.75597538
74* microtubule-based movement (GO:0007018)2.75457388
75lateral sprouting from an epithelium (GO:0060601)2.72589694
76ethanol oxidation (GO:0006069)2.69812517
77retinol metabolic process (GO:0042572)2.68146237
78multicellular organismal water homeostasis (GO:0050891)2.67595647
79establishment of apical/basal cell polarity (GO:0035089)2.67229428
80synaptic vesicle docking involved in exocytosis (GO:0016081)2.66158178
81glutathione derivative biosynthetic process (GO:1901687)2.65542016
82glutathione derivative metabolic process (GO:1901685)2.65542016
83cell projection assembly (GO:0030031)2.65400301
84regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.62708685
85drug catabolic process (GO:0042737)2.62059156
86carnitine metabolic process (GO:0009437)2.61642431
87locomotory exploration behavior (GO:0035641)2.60542714
88organelle assembly (GO:0070925)2.60422384
89eye photoreceptor cell differentiation (GO:0001754)2.57877599
90photoreceptor cell differentiation (GO:0046530)2.57877599
91sperm motility (GO:0030317)2.57785376
92asymmetric protein localization (GO:0008105)2.56368345
93negative regulation of inclusion body assembly (GO:0090084)2.56237509
94ethanol metabolic process (GO:0006067)2.56151039
95regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.54835788
96cellular response to nitric oxide (GO:0071732)2.54459064
97camera-type eye morphogenesis (GO:0048593)2.54158399
98response to gravity (GO:0009629)2.53914772
99heart looping (GO:0001947)2.53849603
100renal system process involved in regulation of blood volume (GO:0001977)2.51552139
101axonal fasciculation (GO:0007413)2.49439594
102positive regulation of glycoprotein biosynthetic process (GO:0010560)2.48842256
103excretion (GO:0007588)2.48285588
104dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.48085070
105apical protein localization (GO:0045176)2.47335829
106collecting duct development (GO:0072044)2.46285845
107carnitine transmembrane transport (GO:1902603)2.46227747
108left/right pattern formation (GO:0060972)2.45911046
109response to auditory stimulus (GO:0010996)2.44950221
110regulation of dendritic cell antigen processing and presentation (GO:0002604)2.43080022
111phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.42678223
112calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.41198382
113hydrogen peroxide biosynthetic process (GO:0050665)2.41186780
114hypotonic response (GO:0006971)2.40011126
115regulation of microtubule depolymerization (GO:0031114)2.38421650
116retina layer formation (GO:0010842)2.37953475
117aldehyde catabolic process (GO:0046185)2.37704858
118CDP-diacylglycerol biosynthetic process (GO:0016024)2.36676815
119water homeostasis (GO:0030104)2.36540747
120protein O-linked glycosylation (GO:0006493)2.36420475
121neuron recognition (GO:0008038)2.35349337
122positive regulation of endothelial cell differentiation (GO:0045603)2.35086264
123sensory perception of smell (GO:0007608)2.34242139
124auditory behavior (GO:0031223)2.32292141
125regulation of steroid hormone biosynthetic process (GO:0090030)2.31763260
126embryonic heart tube morphogenesis (GO:0003143)2.31621099
127regulation of smoothened signaling pathway (GO:0008589)2.28903243
128phosphatidylcholine biosynthetic process (GO:0006656)2.28640827
129nonmotile primary cilium assembly (GO:0035058)2.28440609
130neurotransmitter-gated ion channel clustering (GO:0072578)2.28275084
131limb bud formation (GO:0060174)2.28092987
132quaternary ammonium group transport (GO:0015697)2.27451383
133postsynaptic membrane organization (GO:0001941)2.27399134
134imidazole-containing compound metabolic process (GO:0052803)2.26524504
135positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.24792756
136trivalent inorganic anion homeostasis (GO:0072506)2.24400716
137phosphate ion homeostasis (GO:0055062)2.24400716
138guanosine-containing compound biosynthetic process (GO:1901070)2.24376189
139nucleotide phosphorylation (GO:0046939)2.24002818
140regulation of beta-amyloid formation (GO:1902003)2.22719824
141establishment of nucleus localization (GO:0040023)2.21669037
142negative regulation of B cell mediated immunity (GO:0002713)2.21420635
143negative regulation of immunoglobulin mediated immune response (GO:0002890)2.21420635
144glutamate secretion (GO:0014047)2.19519483
145presynaptic membrane assembly (GO:0097105)2.18312593
146membrane assembly (GO:0071709)2.17811167
147regulation of macrophage chemotaxis (GO:0010758)2.17317442
148regulation of short-term neuronal synaptic plasticity (GO:0048172)2.17256645
149negative regulation of hormone metabolic process (GO:0032351)2.16858439
150negative regulation of hormone biosynthetic process (GO:0032353)2.16858439
151regulation of endothelial cell differentiation (GO:0045601)2.16325011
152mating behavior (GO:0007617)2.15411086
153otic vesicle formation (GO:0030916)2.15106439
154positive regulation of cellular response to insulin stimulus (GO:1900078)2.14660901
155layer formation in cerebral cortex (GO:0021819)2.14511780
156regulation of cAMP-dependent protein kinase activity (GO:2000479)2.14089289
157regulation of hippo signaling (GO:0035330)2.13809793
158regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.12721055
159CTP metabolic process (GO:0046036)2.11297093
160CTP biosynthetic process (GO:0006241)2.11297093
161oxygen transport (GO:0015671)2.08742372
162substrate-independent telencephalic tangential migration (GO:0021826)2.06573378
163substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.06573378
164nonribosomal peptide biosynthetic process (GO:0019184)2.04894591
165cerebral cortex neuron differentiation (GO:0021895)2.04311354

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human3.02316042
2EZH2_22144423_ChIP-Seq_EOC_Human2.74313750
3PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.62944977
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.52897159
5VDR_22108803_ChIP-Seq_LS180_Human2.32804725
6GBX2_23144817_ChIP-Seq_PC3_Human2.31824035
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.12605126
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.11884029
9AR_21572438_ChIP-Seq_LNCaP_Human2.06156101
10SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.98508415
11TRIM28_21343339_ChIP-Seq_HEK293_Human1.97698617
12DROSHA_22980978_ChIP-Seq_HELA_Human1.95947436
13JARID2_20064375_ChIP-Seq_MESCs_Mouse1.93668598
14* PIAS1_25552417_ChIP-Seq_VCAP_Human1.92985280
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.91534780
16FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.87243039
17EZH2_18974828_ChIP-Seq_MESCs_Mouse1.86150646
18RNF2_18974828_ChIP-Seq_MESCs_Mouse1.86150646
19* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.82377289
20SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.81980037
21ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.79218066
22GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.78735002
23* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.78235548
24MTF2_20144788_ChIP-Seq_MESCs_Mouse1.76663485
25EED_16625203_ChIP-ChIP_MESCs_Mouse1.76647488
26JARID2_20075857_ChIP-Seq_MESCs_Mouse1.75282247
27SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.72871591
28TP63_23658742_ChIP-Seq_EP156T_Human1.72233130
29* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.71377203
30ESR2_21235772_ChIP-Seq_MCF-7_Human1.65265408
31CTNNB1_20460455_ChIP-Seq_HCT116_Human1.65131706
32ESR1_21235772_ChIP-Seq_MCF-7_Human1.65024383
33* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.63516048
34TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.62668139
35* SMAD4_21799915_ChIP-Seq_A2780_Human1.62056330
36* ARNT_22903824_ChIP-Seq_MCF-7_Human1.61591857
37EZH2_27294783_Chip-Seq_ESCs_Mouse1.60123802
38EZH2_27304074_Chip-Seq_ESCs_Mouse1.59534294
39* AHR_22903824_ChIP-Seq_MCF-7_Human1.58430805
40SOX2_27498859_Chip-Seq_STOMACH_Mouse1.52538990
41SUZ12_27294783_Chip-Seq_ESCs_Mouse1.52442625
42* FOXA1_25552417_ChIP-Seq_VCAP_Human1.51348256
43ZFP57_27257070_Chip-Seq_ESCs_Mouse1.45766877
44SOX9_24532713_ChIP-Seq_HFSC_Mouse1.45472702
45P300_19829295_ChIP-Seq_ESCs_Human1.45348639
46TAF15_26573619_Chip-Seq_HEK293_Human1.45300835
47RNF2_27304074_Chip-Seq_ESCs_Mouse1.44739085
48CDX2_19796622_ChIP-Seq_MESCs_Mouse1.43225150
49TP53_16413492_ChIP-PET_HCT116_Human1.42405255
50PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.42302236
51RUNX1_27514584_Chip-Seq_MCF-7_Human1.40038319
52SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36162426
53SOX2_20726797_ChIP-Seq_SW620_Human1.35995665
54CTBP1_25329375_ChIP-Seq_LNCAP_Human1.35562246
55FOXO3_23340844_ChIP-Seq_DLD1_Human1.31375283
56* SMAD3_21741376_ChIP-Seq_EPCs_Human1.29422372
57NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.28934284
58TOP2B_26459242_ChIP-Seq_MCF-7_Human1.28332393
59CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.27523009
60SMRT_27268052_Chip-Seq_Bcells_Human1.26656138
61* TP53_18474530_ChIP-ChIP_U2OS_Human1.26342598
62STAT1_20625510_ChIP-Seq_HELA_Human1.25957492
63BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.25689602
64ETV1_20927104_ChIP-Seq_GIST48_Human1.24783985
65* STAT3_23295773_ChIP-Seq_U87_Human1.23749484
66NR3C1_21868756_ChIP-Seq_MCF10A_Human1.23485786
67* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.22638537
68FOXA2_19822575_ChIP-Seq_HepG2_Human1.21872749
69* KLF5_25053715_ChIP-Seq_YYC3_Human1.21391536
70PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.21356147
71BMI1_23680149_ChIP-Seq_NPCS_Mouse1.20607840
72TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.20515784
73STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.20315439
74SMAD_19615063_ChIP-ChIP_OVARY_Human1.20230720
75CBX2_27304074_Chip-Seq_ESCs_Mouse1.19610526
76* AR_25329375_ChIP-Seq_VCAP_Human1.19268038
77* BCAT_22108803_ChIP-Seq_LS180_Human1.17779367
78CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.17302842
79POU3F2_20337985_ChIP-ChIP_501MEL_Human1.17181478
80* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.16954052
81CDX2_20551321_ChIP-Seq_CACO-2_Human1.15005843
82RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.14737013
83SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.14679566
84OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14365769
85ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.13900632
86BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.13549493
87RUNX2_22187159_ChIP-Seq_PCA_Human1.13037975
88GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12679027
89PHF8_20622853_ChIP-Seq_HELA_Human1.11821813
90* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.11409453
91TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.10884896
92REST_21632747_ChIP-Seq_MESCs_Mouse1.10177654
93* GATA4_25053715_ChIP-Seq_YYC3_Human1.09472580
94EP300_21415370_ChIP-Seq_HL-1_Mouse1.09423595
95ESR1_20079471_ChIP-ChIP_T-47D_Human1.08730947
96SMAD4_21741376_ChIP-Seq_HESCs_Human1.08394777
97P63_26484246_Chip-Seq_KERATINOCYTES_Human1.07707067
98SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07700908
99SOX2_21211035_ChIP-Seq_LN229_Gbm1.07671472
100HNFA_21074721_ChIP-Seq_CACO-2_Human1.07648407
101SMAD4_21741376_ChIP-Seq_EPCs_Human1.07448013
102TCF4_23295773_ChIP-Seq_U87_Human1.07256428
103NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.07151988
104NRF2_20460467_ChIP-Seq_MEFs_Mouse1.07151988
105TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06931615
106FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.06498580
107TDRD3_21172665_ChIP-Seq_MCF-7_Human1.05951901
108* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.04833109
109GATA3_24758297_ChIP-Seq_MCF-7_Human1.04690984
110NANOG_18555785_Chip-Seq_ESCs_Mouse1.04551834
111TP63_22573176_ChIP-Seq_HFKS_Human1.04425545
112* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.04420100
113RNF2_27304074_Chip-Seq_NSC_Mouse1.03901231
114CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.03862017
115LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03697850
116SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.03007149
117EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.02952662
118PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.02641499
119SUZ12_27294783_Chip-Seq_NPCs_Mouse1.01677052
120PCGF2_27294783_Chip-Seq_NPCs_Mouse1.01659952
121TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.01461702
122TBL1_22424771_ChIP-Seq_293T_Human1.01095726
123ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.01021734
124* SMC4_20622854_ChIP-Seq_HELA_Human1.00779797
125TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.00540680
126PCGF2_27294783_Chip-Seq_ESCs_Mouse1.00337346
127ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.99423949
128SMAD3_21741376_ChIP-Seq_HESCs_Human0.99307859
129RING1B_27294783_Chip-Seq_ESCs_Mouse0.99125658
130CDX2_22108803_ChIP-Seq_LS180_Human0.98180618
131PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.97793176
132NFYA_21822215_ChIP-Seq_K562_Human0.97681213
133NFYB_21822215_ChIP-Seq_K562_Human0.97656703
134RBPJ_21746931_ChIP-Seq_IB4_Human0.97497429
135FLI1_27457419_Chip-Seq_LIVER_Mouse0.97287738
136MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.97172634
137CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96823270
138ER_23166858_ChIP-Seq_MCF-7_Human0.95197165
139E2F1_18555785_Chip-Seq_ESCs_Mouse0.95179144
140RAD21_21589869_ChIP-Seq_MESCs_Mouse0.94658697
141UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.93103483
142* CJUN_26792858_Chip-Seq_BT549_Human0.92351121
143CBP_20019798_ChIP-Seq_JUKART_Human0.92191898
144IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.92191898
145AR_19668381_ChIP-Seq_PC3_Human0.92141907
146NFE2_27457419_Chip-Seq_LIVER_Mouse0.91842192
147CBX2_22325352_ChIP-Seq_293T-Rex_Human0.91745078
148RXR_22108803_ChIP-Seq_LS180_Human0.91563453
149RBPJ_22232070_ChIP-Seq_NCS_Mouse0.91478737
150CMYC_18555785_Chip-Seq_ESCs_Mouse0.91425923
151P53_22387025_ChIP-Seq_ESCs_Mouse0.91056004
152TCF4_22108803_ChIP-Seq_LS180_Human0.90904735
153SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.89520727

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002138_abnormal_hepatobiliary_system4.46432971
2MP0004043_abnormal_pH_regulation3.90285218
3MP0008004_abnormal_stomach_pH3.27770587
4MP0004782_abnormal_surfactant_physiolog3.07810895
5MP0003136_yellow_coat_color3.02068778
6MP0001958_emphysema2.96091769
7MP0004859_abnormal_synaptic_plasticity2.69378092
8MP0008789_abnormal_olfactory_epithelium2.49612282
9MP0008875_abnormal_xenobiotic_pharmacok2.37272420
10MP0000566_synostosis2.16890214
11MP0005623_abnormal_meninges_morphology2.16204049
12MP0001440_abnormal_grooming_behavior2.15979043
13MP0002928_abnormal_bile_duct2.10220643
14MP0005647_abnormal_sex_gland2.09649999
15MP0002653_abnormal_ependyma_morphology2.00890020
16MP0002139_abnormal_hepatobiliary_system1.99606185
17MP0004270_analgesia1.88597214
18MP0003656_abnormal_erythrocyte_physiolo1.88366666
19MP0001765_abnormal_ion_homeostasis1.86885224
20MP0003880_abnormal_central_pattern1.85932063
21MP0002133_abnormal_respiratory_system1.85622556
22MP0005388_respiratory_system_phenotype1.85622556
23MP0000678_abnormal_parathyroid_gland1.84861943
24MP0005646_abnormal_pituitary_gland1.83725489
25MP0001485_abnormal_pinna_reflex1.80601035
26MP0009745_abnormal_behavioral_response1.79290043
27MP0004133_heterotaxia1.78613654
28MP0003635_abnormal_synaptic_transmissio1.77919671
29MP0002876_abnormal_thyroid_physiology1.77526354
30MP0010234_abnormal_vibrissa_follicle1.77512665
31MP0001968_abnormal_touch/_nociception1.73970268
32MP0008995_early_reproductive_senescence1.73624302
33MP0002734_abnormal_mechanical_nocicepti1.73189731
34MP0003878_abnormal_ear_physiology1.72023290
35MP0005377_hearing/vestibular/ear_phenot1.72023290
36MP0002909_abnormal_adrenal_gland1.71645475
37MP0003252_abnormal_bile_duct1.70074710
38MP0002254_reproductive_system_inflammat1.69873668
39MP0004858_abnormal_nervous_system1.69488387
40MP0001984_abnormal_olfaction1.67213987
41MP0001177_atelectasis1.66439665
42MP0003690_abnormal_glial_cell1.65449937
43MP0001486_abnormal_startle_reflex1.62452617
44MP0004019_abnormal_vitamin_homeostasis1.61818876
45MP0001348_abnormal_lacrimal_gland1.60185580
46MP0002736_abnormal_nociception_after1.59178283
47MP0003879_abnormal_hair_cell1.55592371
48MP0005167_abnormal_blood-brain_barrier1.52536218
49MP0002735_abnormal_chemical_nociception1.51362395
50MP0002572_abnormal_emotion/affect_behav1.50296510
51MP0005394_taste/olfaction_phenotype1.45310824
52MP0005499_abnormal_olfactory_system1.45310824
53MP0002160_abnormal_reproductive_system1.43893840
54MP0000778_abnormal_nervous_system1.42926734
55MP0002249_abnormal_larynx_morphology1.42611158
56MP0005395_other_phenotype1.40712324
57MP0009780_abnormal_chondrocyte_physiolo1.38652523
58MP0002277_abnormal_respiratory_mucosa1.38286283
59MP0002063_abnormal_learning/memory/cond1.36755771
60MP0002064_seizures1.36745454
61MP0001501_abnormal_sleep_pattern1.36615951
62MP0009046_muscle_twitch1.36461376
63MP0002557_abnormal_social/conspecific_i1.30804590
64MP0005220_abnormal_exocrine_pancreas1.30211597
65MP0005636_abnormal_mineral_homeostasis1.28344162
66MP0009384_cardiac_valve_regurgitation1.28326247
67MP0002168_other_aberrant_phenotype1.23098550
68MP0005645_abnormal_hypothalamus_physiol1.22294915
69MP0005248_abnormal_Harderian_gland1.21936206
70MP0002295_abnormal_pulmonary_circulatio1.17877864
71MP0010678_abnormal_skin_adnexa1.17839782
72MP0005310_abnormal_salivary_gland1.14607926
73MP0004272_abnormal_basement_membrane1.14446296
74MP0005503_abnormal_tendon_morphology1.13778077
75MP0002733_abnormal_thermal_nociception1.08116260
76MP0002272_abnormal_nervous_system1.07691998
77MP0002132_abnormal_respiratory_system1.07392022
78MP0003075_altered_response_to1.06988253
79MP0003045_fibrosis1.06861324
80MP0000026_abnormal_inner_ear1.06238493
81MP0000681_abnormal_thyroid_gland1.02876928
82MP0001970_abnormal_pain_threshold1.02414706
83MP0001502_abnormal_circadian_rhythm1.00352196
84MP0003195_calcinosis0.99074019
85MP0001346_abnormal_lacrimal_gland0.98205022
86MP0004742_abnormal_vestibular_system0.97987073
87MP0000613_abnormal_salivary_gland0.96551400
88MP0001944_abnormal_pancreas_morphology0.95959804
89MP0009643_abnormal_urine_homeostasis0.94478843
90MP0003634_abnormal_glial_cell0.93706268
91MP0000383_abnormal_hair_follicle0.93584652
92MP0005253_abnormal_eye_physiology0.90964273
93MP0005423_abnormal_somatic_nervous0.90928648
94MP0003942_abnormal_urinary_system0.90087527
95MP0002282_abnormal_trachea_morphology0.89295930
96MP0002184_abnormal_innervation0.88064978
97MP0010368_abnormal_lymphatic_system0.86958581
98MP0000467_abnormal_esophagus_morphology0.86878585
99MP0001943_abnormal_respiration0.85705760
100MP0000470_abnormal_stomach_morphology0.84672137
101MP0003329_amyloid_beta_deposits0.84219832
102MP0001299_abnormal_eye_distance/0.83275518
103MP0002136_abnormal_kidney_physiology0.82828174
104MP0005165_increased_susceptibility_to0.82673643
105MP0001270_distended_abdomen0.82639274
106MP0001963_abnormal_hearing_physiology0.81960920
107MP0005083_abnormal_biliary_tract0.80648819
108MP0002882_abnormal_neuron_morphology0.80628646
109MP0003724_increased_susceptibility_to0.80052453
110MP0003937_abnormal_limbs/digits/tail_de0.79324426
111MP0003633_abnormal_nervous_system0.79082440
112MP0002638_abnormal_pupillary_reflex0.79006876
113MP0005389_reproductive_system_phenotype0.78279258
114MP0005551_abnormal_eye_electrophysiolog0.77755707
115MP0002896_abnormal_bone_mineralization0.76397591
116MP0005164_abnormal_response_to0.74948047
117MP0002067_abnormal_sensory_capabilities0.74945476
118MP0010155_abnormal_intestine_physiology0.74626024
119MP0005408_hypopigmentation0.74147294
120MP0005365_abnormal_bile_salt0.74091495
121MP0001851_eye_inflammation0.73750373
122MP0006276_abnormal_autonomic_nervous0.73513206
123MP0001879_abnormal_lymphatic_vessel0.73460586
124MP0005085_abnormal_gallbladder_physiolo0.73437215
125MP0004885_abnormal_endolymph0.71952948
126MP0001873_stomach_inflammation0.71884460
127MP0002108_abnormal_muscle_morphology0.70139005
128MP0003283_abnormal_digestive_organ0.69609296
129MP0002752_abnormal_somatic_nervous0.69299700
130MP0001664_abnormal_digestion0.67935767
131MP0004883_abnormal_blood_vessel0.66901460
132MP0003950_abnormal_plasma_membrane0.66550595
133MP0002233_abnormal_nose_morphology0.66183209
134MP0010030_abnormal_orbit_morphology0.66077077
135MP0003890_abnormal_embryonic-extraembry0.63201271
136MP0009703_decreased_birth_body0.62298340
137MP0002229_neurodegeneration0.62264831
138MP0004264_abnormal_extraembryonic_tissu0.62232041
139MP0003698_abnormal_male_reproductive0.60200233
140MP0001929_abnormal_gametogenesis0.57455624
141MP0000465_gastrointestinal_hemorrhage0.57203342
142MP0001324_abnormal_eye_pigmentation0.56931682
143MP0002116_abnormal_craniofacial_bone0.55087002
144MP0003453_abnormal_keratinocyte_physiol0.53347018
145MP0000013_abnormal_adipose_tissue0.52548289
146MP0001756_abnormal_urination0.51971539
147MP0000631_abnormal_neuroendocrine_gland0.51394656
148MP0002135_abnormal_kidney_morphology0.50735095
149MP0002822_catalepsy0.49727519
150MP0003943_abnormal_hepatobiliary_system0.48536288
151MP0010352_gastrointestinal_tract_polyps0.48229963
152MP0005195_abnormal_posterior_eye0.48138021
153MP0002405_respiratory_system_inflammati0.47102272
154MP0005391_vision/eye_phenotype0.46863895
155MP0002098_abnormal_vibrissa_morphology0.45908857
156MP0005023_abnormal_wound_healing0.44552258

Predicted human phenotypes

RankGene SetZ-score
1Abnormal ciliary motility (HP:0012262)9.96094149
2Rhinitis (HP:0012384)8.13068777
3Chronic bronchitis (HP:0004469)8.02826924
4Abnormal respiratory epithelium morphology (HP:0012253)7.45984294
5Abnormal respiratory motile cilium morphology (HP:0005938)7.45984294
6Dynein arm defect of respiratory motile cilia (HP:0012255)7.05214284
7Absent/shortened dynein arms (HP:0200106)7.05214284
8Bronchiectasis (HP:0002110)5.04884018
9Tubulointerstitial nephritis (HP:0001970)3.87892135
10Abnormality of the nasal mucosa (HP:0000433)3.85252016
11Pancreatic fibrosis (HP:0100732)3.79248144
12Nasal polyposis (HP:0100582)3.76729493
13True hermaphroditism (HP:0010459)3.63858017
14Bronchitis (HP:0012387)3.47676208
15Abnormality of dentin (HP:0010299)3.30562386
16Chronic sinusitis (HP:0011109)3.02747011
17Cystic liver disease (HP:0006706)2.97651026
18Hyperactive renin-angiotensin system (HP:0000841)2.87920437
19Chronic otitis media (HP:0000389)2.87392576
20Tubulointerstitial abnormality (HP:0001969)2.76020700
21Nephronophthisis (HP:0000090)2.70122214
22Recurrent sinusitis (HP:0011108)2.69652004
23Medial flaring of the eyebrow (HP:0010747)2.67287843
24Occipital encephalocele (HP:0002085)2.62956874
25Pancreatic cysts (HP:0001737)2.59683621
26Gait imbalance (HP:0002141)2.54142891
27Tubulointerstitial fibrosis (HP:0005576)2.50334292
28Congenital hepatic fibrosis (HP:0002612)2.47765992
29Chronic hepatic failure (HP:0100626)2.44918451
30Abnormality of the dental pulp (HP:0006479)2.40969871
31Congenital primary aphakia (HP:0007707)2.38384457
32Interstitial pulmonary disease (HP:0006530)2.37596690
33Abnormality of the renal medulla (HP:0100957)2.33895423
34Recurrent bronchitis (HP:0002837)2.33634788
35Bile duct proliferation (HP:0001408)2.32526337
36Abnormal biliary tract physiology (HP:0012439)2.32526337
37Genital tract atresia (HP:0001827)2.27574882
38Abnormality of midbrain morphology (HP:0002418)2.25212236
39Molar tooth sign on MRI (HP:0002419)2.25212236
40Abnormality of the dental root (HP:0006486)2.23147115
41Taurodontia (HP:0000679)2.23147115
42Abnormality of permanent molar morphology (HP:0011071)2.23147115
43Infertility (HP:0000789)2.21156159
44Single umbilical artery (HP:0001195)2.18028600
45Abnormality of the fetal cardiovascular system (HP:0010948)2.18028600
46Abnormal umbilical cord blood vessels (HP:0011403)2.18028600
47Postaxial foot polydactyly (HP:0001830)2.17005414
48Abnormality of molar morphology (HP:0011070)2.16711916
49Abnormality of molar (HP:0011077)2.16711916
50Stage 5 chronic kidney disease (HP:0003774)2.16267618
51Vaginal atresia (HP:0000148)2.13625840
52Tubular atrophy (HP:0000092)2.12890816
53Nephrogenic diabetes insipidus (HP:0009806)2.09721054
54Median cleft lip (HP:0000161)2.09393896
55Back pain (HP:0003418)2.08460641
56Bell-shaped thorax (HP:0001591)2.05311544
57Recurrent otitis media (HP:0000403)2.04504998
58Male pseudohermaphroditism (HP:0000037)2.02934869
59Respiratory insufficiency due to defective ciliary clearance (HP:0200073)11.4060494
60Abnormal respiratory motile cilium physiology (HP:0012261)10.4335189
61Renal salt wasting (HP:0000127)1.99826387
62Focal motor seizures (HP:0011153)1.96987495
63Absent frontal sinuses (HP:0002688)1.95647193
64Supernumerary spleens (HP:0009799)1.95316565
65Aplasia/Hypoplasia of the tongue (HP:0010295)1.95104021
66Bronchomalacia (HP:0002780)1.90077319
67Aplasia involving bones of the extremities (HP:0009825)1.89929595
68Aplasia involving bones of the upper limbs (HP:0009823)1.89929595
69Aplasia of the phalanges of the hand (HP:0009802)1.89929595
70Anencephaly (HP:0002323)1.88615848
71Ankle clonus (HP:0011448)1.87487617
72Absent rod-and cone-mediated responses on ERG (HP:0007688)1.87286391
73Decreased circulating renin level (HP:0003351)1.84771577
74Neurofibrillary tangles (HP:0002185)1.82116731
75Hyperkalemia (HP:0002153)1.77174500
76Hyperaldosteronism (HP:0000859)1.77151311
77Facial shape deformation (HP:0011334)1.74942977
78Potter facies (HP:0002009)1.74942977
79Broad distal phalanx of finger (HP:0009836)1.74175162
80Atelectasis (HP:0100750)1.70308048
81Onycholysis (HP:0001806)1.68394449
82Postaxial hand polydactyly (HP:0001162)1.67506223
83Tachypnea (HP:0002789)1.67468649
84Poor coordination (HP:0002370)1.65631952
85Oculomotor apraxia (HP:0000657)1.62798319
86Abnormality of the renal cortex (HP:0011035)1.62322311
87Asplenia (HP:0001746)1.60565345
88Abnormality of renin-angiotensin system (HP:0000847)1.59965699
89Sclerocornea (HP:0000647)1.58695586
90Nephropathy (HP:0000112)1.58500667
91Preaxial hand polydactyly (HP:0001177)1.58392574
92Aplasia/Hypoplasia of the spleen (HP:0010451)1.58352802
93Furrowed tongue (HP:0000221)1.56525700
94Respiratory distress (HP:0002098)1.56408362
95Sex reversal (HP:0012245)1.55680997
96Abnormal sex determination (HP:0012244)1.55680997
97Male infertility (HP:0003251)1.55167817
98Supranuclear gaze palsy (HP:0000605)1.52012771
99Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.49273311
100Hypodontia (HP:0000668)1.49144787
101Genetic anticipation (HP:0003743)1.45893729
102Decreased central vision (HP:0007663)1.45535958
103Megalencephaly (HP:0001355)1.45516171
104Lower limb muscle weakness (HP:0007340)1.44428277
105Focal seizures (HP:0007359)1.44113904
106Polycystic kidney dysplasia (HP:0000113)1.43342652
107Glucose intolerance (HP:0000833)1.42903083
108Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.42472834
109Degeneration of the lateral corticospinal tracts (HP:0002314)1.42472834
110Polycythemia (HP:0001901)1.42346852
111Aplasia/Hypoplasia of the lens (HP:0008063)1.42131643
112Febrile seizures (HP:0002373)1.40694091
113Scanning speech (HP:0002168)1.40410708
114Cone-rod dystrophy (HP:0000548)1.39977404
115Short thorax (HP:0010306)1.38445685
116Short nail (HP:0001799)1.30224107
117Abnormality of chloride homeostasis (HP:0011422)1.23039931
118Abnormal rod and cone electroretinograms (HP:0008323)1.22933726
119Abnormality of the frontal sinuses (HP:0002687)1.20305190
120Polydipsia (HP:0001959)1.18458850
121Abnormal drinking behavior (HP:0030082)1.18458850
122Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.18133129
123Lip pit (HP:0100267)1.17265143
124Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.16854435
125Bifid scrotum (HP:0000048)1.15581906
126Abnormality of the distal phalanges of the toes (HP:0010182)1.08807885
127Hypokalemic alkalosis (HP:0001949)1.07200058
128Facial cleft (HP:0002006)1.04765542
129Vascular calcification (HP:0004934)1.00865458
130Retinitis pigmentosa (HP:0000510)1.00311657
131Hand muscle atrophy (HP:0009130)0.99713534
132Popliteal pterygium (HP:0009756)0.98040200
133Fetal akinesia sequence (HP:0001989)0.97842316
134Renal dysplasia (HP:0000110)0.96043656

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK156.02132212
2PNCK3.84323584
3CASK3.65285674
4FRK3.23965783
5GRK12.58588012
6DAPK22.43604007
7NTRK22.37096389
8MST42.08050072
9LMTK22.04068529
10TIE12.03984065
11MAPKAPK31.99800117
12LATS11.96796696
13MARK11.93562418
14EEF2K1.91115558
15ERBB31.80643317
16STK241.77890161
17NME11.71621920
18FER1.66478221
19SIK11.59754225
20NTRK31.57347690
21TTK1.42500302
22PHKG11.34375120
23PHKG21.34375120
24MAP3K31.30140603
25EPHA41.29563194
26MAP3K71.28253377
27SGK21.21571687
28MAP2K71.21001783
29MAP3K91.17304107
30NTRK11.16136691
31SGK4941.14774439
32SGK2231.14774439
33MAP3K21.14769817
34STK38L1.11492541
35DMPK1.11152591
36MAP3K41.09731853
37FGFR21.09454482
38NEK61.08616911
39MINK11.08308576
40MARK21.07789617
41TRPM71.07448182
42ROCK21.05935811
43SMG11.05193090
44MUSK1.04248850
45CSK1.03435366
46PAK61.03022419
47PRKCH0.97455461
48SGK30.97047210
49PAK30.96833671
50STK380.95943906
51BCR0.93491250
52PRKCG0.92406107
53RPS6KA20.91280360
54ROCK10.90136985
55MAP3K120.90125934
56LRRK20.89225522
57TGFBR20.88386509
58CDC42BPA0.86338829
59BRSK20.85769668
60PRKCI0.84825402
61DDR20.84360442
62LATS20.83701762
63PRKCE0.83578238
64MAPK130.83078951
65PLK20.81574719
66PINK10.81233535
67IRAK10.78006755
68TAOK10.76800747
69MAPKAPK50.75493399
70DYRK1A0.74917540
71CSNK1G10.74643408
72MAP2K40.74463877
73OXSR10.73509639
74ICK0.72308704
75EPHB20.71461239
76CAMK2A0.71143747
77MET0.70201428
78CDK50.68773686
79CAMK1G0.67411513
80BMPR1B0.67330254
81FGFR30.66940310
82GRK50.65772424
83DYRK1B0.65486290
84BMPR20.64545231
85CAMK2B0.63203773
86TLK10.61466845
87GSK3A0.58028318
88STK110.57871381
89MST1R0.55792294
90NLK0.55709794
91STK100.55691390
92KSR10.55678642
93TESK10.55158391
94PRKD10.54809971
95MAP2K10.54704265
96PTK20.54088399
97PRKCQ0.53078321
98PAK20.52808924
99EPHB10.52775692
100CAMK1D0.52700124
101INSRR0.52583757
102KSR20.52150639
103CAMKK20.51880618
104ERBB40.51230486
105NEK90.50963468
106PTK2B0.50716434
107ACVR1B0.50386371
108MAP3K60.49088981
109TNK20.48634253
110HIPK20.47892178
111DYRK30.46533651
112PKN10.46492881
113ADRBK10.45396499
114SRC0.44793321
115MYLK0.44766578
116FGR0.44653959
117ERBB20.43676175
118SGK10.43208632
119CDK30.42644833
120CAMKK10.41904338
121STK390.41787002
122TBK10.41498671
123PRKAA20.41043554
124CSNK1G20.40529535
125PRKACA0.39555933
126AKT30.38340784
127FYN0.38305638
128CAMK2G0.38025492
129PRKD20.37970483
130MAP3K10.37946961
131PRKG10.37504875
132EPHA20.36451933
133STK30.35453529
134PDPK10.34885855
135PTK60.34529072
136PRKCZ0.34214543
137EPHA30.32582737
138PASK0.30814276
139AURKA0.30052853
140STK160.28728162
141PRKCD0.28631793
142RPS6KB20.28481895
143TRIB30.27398348
144ABL10.25494374
145PRKAA10.25291962
146CHUK0.22760988
147CDK120.22612321
148ADRBK20.22329740
149PRKCA0.21552699
150AKT20.21017199
151TYK20.20743406
152PRKD30.20294073
153MELK0.19986657
154RET0.19585362
155EGFR0.18581677

Predicted pathways (KEGG)

RankGene SetZ-score
1Caffeine metabolism_Homo sapiens_hsa002322.51089689
2Histidine metabolism_Homo sapiens_hsa003402.43956418
3Huntingtons disease_Homo sapiens_hsa050162.43407325
4Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.38188855
5Nicotine addiction_Homo sapiens_hsa050332.35347851
6Olfactory transduction_Homo sapiens_hsa047402.17488347
7Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.14467573
8Sphingolipid metabolism_Homo sapiens_hsa006001.98837924
9GABAergic synapse_Homo sapiens_hsa047271.70209149
10Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.68653269
11Gastric acid secretion_Homo sapiens_hsa049711.67100321
12Salivary secretion_Homo sapiens_hsa049701.60553511
13Chemical carcinogenesis_Homo sapiens_hsa052041.59075790
14Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.56203944
15Fatty acid biosynthesis_Homo sapiens_hsa000611.54482014
16Morphine addiction_Homo sapiens_hsa050321.52286712
17Taste transduction_Homo sapiens_hsa047421.52096377
18Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.49663439
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.49530101
20Vitamin B6 metabolism_Homo sapiens_hsa007501.46830186
21Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.45654985
22Glutamatergic synapse_Homo sapiens_hsa047241.44036289
23Ovarian steroidogenesis_Homo sapiens_hsa049131.44014696
24Circadian entrainment_Homo sapiens_hsa047131.43033286
25Synaptic vesicle cycle_Homo sapiens_hsa047211.42539865
26Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.38762272
27Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.37327048
28Amphetamine addiction_Homo sapiens_hsa050311.33547621
29Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.25367952
30Nitrogen metabolism_Homo sapiens_hsa009101.25171664
31Insulin secretion_Homo sapiens_hsa049111.24734913
32Maturity onset diabetes of the young_Homo sapiens_hsa049501.23856336
33Starch and sucrose metabolism_Homo sapiens_hsa005001.22814714
34Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.22224814
35Retinol metabolism_Homo sapiens_hsa008301.20762105
36Axon guidance_Homo sapiens_hsa043601.20688667
37Carbohydrate digestion and absorption_Homo sapiens_hsa049731.20247109
38Phenylalanine metabolism_Homo sapiens_hsa003601.16127460
39Glutathione metabolism_Homo sapiens_hsa004801.15326829
40Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.14637804
41Peroxisome_Homo sapiens_hsa041461.13945864
42Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.07086101
43Renin secretion_Homo sapiens_hsa049241.06763489
44Collecting duct acid secretion_Homo sapiens_hsa049661.03758118
45Arachidonic acid metabolism_Homo sapiens_hsa005901.03166721
46Mineral absorption_Homo sapiens_hsa049781.02911362
47Phototransduction_Homo sapiens_hsa047441.00764978
48ECM-receptor interaction_Homo sapiens_hsa045121.00638505
49Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.99516356
50Calcium signaling pathway_Homo sapiens_hsa040200.97217896
51Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.97208281
52Cocaine addiction_Homo sapiens_hsa050300.96746022
53Pentose and glucuronate interconversions_Homo sapiens_hsa000400.95240479
54GnRH signaling pathway_Homo sapiens_hsa049120.94480058
55Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.94165046
56Adherens junction_Homo sapiens_hsa045200.93884571
57Vascular smooth muscle contraction_Homo sapiens_hsa042700.93090627
58Dorso-ventral axis formation_Homo sapiens_hsa043200.92803715
59Tight junction_Homo sapiens_hsa045300.91466459
60Thyroid hormone synthesis_Homo sapiens_hsa049180.90769048
61Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.90292502
62Melanogenesis_Homo sapiens_hsa049160.90280520
63Tyrosine metabolism_Homo sapiens_hsa003500.90233837
64Bile secretion_Homo sapiens_hsa049760.87506279
65Hippo signaling pathway_Homo sapiens_hsa043900.87033832
66Ether lipid metabolism_Homo sapiens_hsa005650.86887767
67cAMP signaling pathway_Homo sapiens_hsa040240.86744386
68Aldosterone synthesis and secretion_Homo sapiens_hsa049250.86561966
69Butanoate metabolism_Homo sapiens_hsa006500.85524294
70Estrogen signaling pathway_Homo sapiens_hsa049150.84970782
71Tryptophan metabolism_Homo sapiens_hsa003800.84958384
72PPAR signaling pathway_Homo sapiens_hsa033200.80957301
73Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.80680937
74Dopaminergic synapse_Homo sapiens_hsa047280.78998743
75Drug metabolism - other enzymes_Homo sapiens_hsa009830.74928672
76Basal cell carcinoma_Homo sapiens_hsa052170.74674723
77Serotonergic synapse_Homo sapiens_hsa047260.74579730
78Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.74050653
79Cholinergic synapse_Homo sapiens_hsa047250.73364999
80Choline metabolism in cancer_Homo sapiens_hsa052310.72171418
81Fatty acid degradation_Homo sapiens_hsa000710.71065484
82beta-Alanine metabolism_Homo sapiens_hsa004100.70547976
83Long-term potentiation_Homo sapiens_hsa047200.70507331
84Fatty acid elongation_Homo sapiens_hsa000620.70491365
85Long-term depression_Homo sapiens_hsa047300.70371842
86Circadian rhythm_Homo sapiens_hsa047100.70001971
87Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.69178223
88Vibrio cholerae infection_Homo sapiens_hsa051100.69005191
89Primary bile acid biosynthesis_Homo sapiens_hsa001200.68868822
90cGMP-PKG signaling pathway_Homo sapiens_hsa040220.67383417
91Oxytocin signaling pathway_Homo sapiens_hsa049210.66863321
92Gap junction_Homo sapiens_hsa045400.66426541
93Hedgehog signaling pathway_Homo sapiens_hsa043400.65863200
94ABC transporters_Homo sapiens_hsa020100.63839400
95Complement and coagulation cascades_Homo sapiens_hsa046100.62608792
96Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.62062327
97Glycerophospholipid metabolism_Homo sapiens_hsa005640.60421859
98Hepatitis C_Homo sapiens_hsa051600.59819703
99Fatty acid metabolism_Homo sapiens_hsa012120.59153311
100Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.57589052
101Ras signaling pathway_Homo sapiens_hsa040140.57286902
102Steroid hormone biosynthesis_Homo sapiens_hsa001400.56544915
103Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.55858323
104Notch signaling pathway_Homo sapiens_hsa043300.55587770
105Phosphatidylinositol signaling system_Homo sapiens_hsa040700.54954304
106Prion diseases_Homo sapiens_hsa050200.54441397
107Focal adhesion_Homo sapiens_hsa045100.53880567
108Dilated cardiomyopathy_Homo sapiens_hsa054140.52944320
109Pancreatic secretion_Homo sapiens_hsa049720.50952348
110alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.49303240
111Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.48892568
112Phagosome_Homo sapiens_hsa041450.48845340
113Wnt signaling pathway_Homo sapiens_hsa043100.47849655
114Rap1 signaling pathway_Homo sapiens_hsa040150.47762527
115Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.47599239
116Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.46666807
117Leukocyte transendothelial migration_Homo sapiens_hsa046700.45507462
118Transcriptional misregulation in cancer_Homo sapiens_hsa052020.45187933
119Rheumatoid arthritis_Homo sapiens_hsa053230.45032118
120Type II diabetes mellitus_Homo sapiens_hsa049300.43976641
121Insulin resistance_Homo sapiens_hsa049310.43647309
122ErbB signaling pathway_Homo sapiens_hsa040120.43120599
123Linoleic acid metabolism_Homo sapiens_hsa005910.42599096
124Amoebiasis_Homo sapiens_hsa051460.42472017
125Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.37665772
126Prostate cancer_Homo sapiens_hsa052150.34031502
127Glycosaminoglycan degradation_Homo sapiens_hsa005310.31265395
128Regulation of autophagy_Homo sapiens_hsa041400.31229518
129Type I diabetes mellitus_Homo sapiens_hsa049400.29450469
130Hematopoietic cell lineage_Homo sapiens_hsa046400.29119039
131Glycerolipid metabolism_Homo sapiens_hsa005610.29061319
132Jak-STAT signaling pathway_Homo sapiens_hsa046300.27376103
133Vitamin digestion and absorption_Homo sapiens_hsa049770.27189030
134Sphingolipid signaling pathway_Homo sapiens_hsa040710.24528468
135Metabolic pathways_Homo sapiens_hsa011000.21653541
136Lysosome_Homo sapiens_hsa041420.21436809
137mTOR signaling pathway_Homo sapiens_hsa041500.19506170
138Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.16478923
139Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.15890459
140Arginine and proline metabolism_Homo sapiens_hsa003300.14358555

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