DNAH6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the dynein family, whose members encode large proteins that are constituents of the microtubule-associated motor protein complex. This complex is composed of dynein heavy, intermediate and light chains, which can be axonemal or cytoplasmic. This protein is an axonemal dynein heavy chain. It is involved in producing force for ciliary beating by using energy from ATP hydrolysis. Mutations in this gene may cause primary ciliary dyskinesia (PCD) as well as heterotaxy. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1motile cilium assembly (GO:0044458)9.89946850
2fusion of sperm to egg plasma membrane (GO:0007342)9.88907067
3sperm motility (GO:0030317)9.12931669
4piRNA metabolic process (GO:0034587)8.96370121
5multicellular organism reproduction (GO:0032504)8.37415163
6ventricular system development (GO:0021591)8.31662665
7acrosome assembly (GO:0001675)8.31585039
8axoneme assembly (GO:0035082)7.89769391
9sperm-egg recognition (GO:0035036)7.73927776
10plasma membrane fusion (GO:0045026)7.72528372
11male meiosis (GO:0007140)7.25671573
12acrosome reaction (GO:0007340)7.16465576
13regulation of cilium movement (GO:0003352)7.10860834
14binding of sperm to zona pellucida (GO:0007339)7.02287494
15spermatid development (GO:0007286)6.92640227
16cell-cell recognition (GO:0009988)6.88382417
17reproduction (GO:0000003)6.72054451
18negative regulation of inclusion body assembly (GO:0090084)6.51469807
19synaptonemal complex organization (GO:0070193)6.49252564
20single fertilization (GO:0007338)6.18339295
21cell wall macromolecule catabolic process (GO:0016998)6.07720297
22cell wall macromolecule metabolic process (GO:0044036)6.07720297
23synaptonemal complex assembly (GO:0007130)5.67883039
24nucleoside diphosphate phosphorylation (GO:0006165)5.63742576
25intraciliary transport (GO:0042073)5.55404332
26left/right axis specification (GO:0070986)5.50113503
27sperm capacitation (GO:0048240)5.45880762
28GTP biosynthetic process (GO:0006183)5.32532865
29DNA methylation involved in gamete generation (GO:0043046)5.27957191
30fertilization (GO:0009566)5.23833416
31male meiosis I (GO:0007141)5.17153687
32retinal rod cell development (GO:0046548)5.12361870
33cilium organization (GO:0044782)4.76392205
34left/right pattern formation (GO:0060972)4.72918831
35protein localization to cilium (GO:0061512)4.69755921
36primary alcohol catabolic process (GO:0034310)4.62703317
37UTP biosynthetic process (GO:0006228)4.62316636
38vitamin transmembrane transport (GO:0035461)4.62183556
39regulation of inclusion body assembly (GO:0090083)4.58601499
40* microtubule-based movement (GO:0007018)4.54134062
41cilium assembly (GO:0042384)4.48458513
42microtubule severing (GO:0051013)4.48034267
43meiotic cell cycle (GO:0051321)4.44150404
44spermatogenesis (GO:0007283)4.37852326
45regulation of microtubule-based movement (GO:0060632)4.36282962
46male gamete generation (GO:0048232)4.35754656
47retinal cone cell development (GO:0046549)4.28481385
48UTP metabolic process (GO:0046051)4.20415283
49ethanol metabolic process (GO:0006067)4.16426506
50lateral ventricle development (GO:0021670)4.13067695
51photoreceptor cell maintenance (GO:0045494)4.09695499
52cellular component assembly involved in morphogenesis (GO:0010927)4.05970993
53germ cell development (GO:0007281)4.02929976
54gamete generation (GO:0007276)4.02672730
55meiosis I (GO:0007127)3.98859679
56diterpenoid biosynthetic process (GO:0016102)3.98367181
57cellular process involved in reproduction in multicellular organism (GO:0022412)3.98008424
58cilium morphogenesis (GO:0060271)3.95624387
59microtubule bundle formation (GO:0001578)3.93188920
60microtubule polymerization or depolymerization (GO:0031109)3.92140463
61chromosome organization involved in meiosis (GO:0070192)3.90791591
62meiotic nuclear division (GO:0007126)3.84382150
63cell recognition (GO:0008037)3.75366143
64calcium ion-dependent exocytosis (GO:0017156)3.67174733
65protein polyglutamylation (GO:0018095)3.64897409
66regulation of interleukin-5 production (GO:0032674)3.62946466
67negative regulation of humoral immune response (GO:0002921)3.38506195
68glomerular epithelial cell development (GO:0072310)3.38471513
69exogenous drug catabolic process (GO:0042738)3.35884621
70nonmotile primary cilium assembly (GO:0035058)3.35320739
71cytoplasmic microtubule organization (GO:0031122)3.34119662
72lung epithelium development (GO:0060428)3.32101434
73CTP biosynthetic process (GO:0006241)3.29822025
74CTP metabolic process (GO:0046036)3.29822025
75spermatid nucleus differentiation (GO:0007289)3.28658376
76seminiferous tubule development (GO:0072520)3.28038193
77guanosine-containing compound biosynthetic process (GO:1901070)3.25369831
78regulation of centriole replication (GO:0046599)3.24198655
79ethanol oxidation (GO:0006069)3.22989041
80negative regulation of B cell mediated immunity (GO:0002713)3.22237161
81negative regulation of immunoglobulin mediated immune response (GO:0002890)3.22237161
82response to xenobiotic stimulus (GO:0009410)3.22065015
83multicellular organismal reproductive process (GO:0048609)3.20504350
84negative regulation of organelle assembly (GO:1902116)3.19986695
85cell projection assembly (GO:0030031)3.17003644
86organic cation transport (GO:0015695)3.15213398
87pyrimidine-containing compound transmembrane transport (GO:0072531)3.12783366
88regulation of protein polyubiquitination (GO:1902914)3.11561744
89protein refolding (GO:0042026)3.02992752
90centriole replication (GO:0007099)2.99506958
91nucleotide phosphorylation (GO:0046939)2.98056270
92drug catabolic process (GO:0042737)2.97204989
93centriole assembly (GO:0098534)2.96053128
94retinoic acid metabolic process (GO:0042573)2.96046071
95genitalia morphogenesis (GO:0035112)2.95183755
96pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.91844180
97regulation of meiosis I (GO:0060631)2.91811080
98establishment of planar polarity (GO:0001736)2.89877803
99establishment of tissue polarity (GO:0007164)2.89877803
100negative regulation of T cell differentiation in thymus (GO:0033085)2.87989277
101terpenoid biosynthetic process (GO:0016114)2.84506792
102gene silencing by RNA (GO:0031047)2.81172472
103lateral sprouting from an epithelium (GO:0060601)2.77214245
104regulation of interleukin-13 production (GO:0032656)2.75529382
105establishment of apical/basal cell polarity (GO:0035089)2.74873515
106microtubule depolymerization (GO:0007019)2.71851284
107pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.71072694
108tolerance induction (GO:0002507)2.69864756
109determination of left/right symmetry (GO:0007368)2.67755913
110pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.67713113
111establishment of monopolar cell polarity (GO:0061162)2.64920153
112establishment or maintenance of monopolar cell polarity (GO:0061339)2.64920153
113determination of bilateral symmetry (GO:0009855)2.64470393
114positive regulation of smoothened signaling pathway (GO:0045880)2.62420323
115nucleoside diphosphate metabolic process (GO:0009132)2.58697699
116specification of symmetry (GO:0009799)2.58038700
117monoubiquitinated protein deubiquitination (GO:0035520)2.52833415
118* microtubule-based process (GO:0007017)2.50056638
119brain morphogenesis (GO:0048854)2.44454432
120multicellular organismal development (GO:0007275)2.42789112
121establishment of nucleus localization (GO:0040023)2.42701057
122glutathione derivative metabolic process (GO:1901685)2.41354296
123glutathione derivative biosynthetic process (GO:1901687)2.41354296
124regulation of germinal center formation (GO:0002634)2.41230993
125limb development (GO:0060173)2.40575183
126appendage development (GO:0048736)2.40575183
127apical protein localization (GO:0045176)2.38214947
128smoothened signaling pathway (GO:0007224)2.37920622
129heart looping (GO:0001947)2.37582761
130O-glycan processing (GO:0016266)2.37291428
131regulation of microtubule depolymerization (GO:0031114)2.35355059
132organelle assembly (GO:0070925)2.34967163
133intra-S DNA damage checkpoint (GO:0031573)2.34238834
134regulation of smoothened signaling pathway (GO:0008589)2.33109121
135neural tube formation (GO:0001841)2.32235301
136spinal cord motor neuron differentiation (GO:0021522)2.31945895
137excretion (GO:0007588)2.30627262
138eye photoreceptor cell differentiation (GO:0001754)2.29933420
139photoreceptor cell differentiation (GO:0046530)2.29933420
140phosphatidylcholine biosynthetic process (GO:0006656)2.29873768
141regulation of collateral sprouting (GO:0048670)2.29591358
142regulation of podosome assembly (GO:0071801)2.29033572
143retinol metabolic process (GO:0042572)2.27134030
144positive regulation of tolerance induction (GO:0002645)2.25296295
145synapsis (GO:0007129)2.25230158
146carnitine metabolic process (GO:0009437)2.24837436
147regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.24635544
148primary alcohol metabolic process (GO:0034308)2.23385195
149pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.23196695
150photoreceptor cell development (GO:0042461)2.22113303
151lactate metabolic process (GO:0006089)2.21373549
152nucleus localization (GO:0051647)2.21167396
153regulation of cilium assembly (GO:1902017)2.20007404
154meiotic cell cycle process (GO:1903046)2.19918138
155cellular response to gamma radiation (GO:0071480)2.18629640
156carnitine transmembrane transport (GO:1902603)2.17742330
157one-carbon compound transport (GO:0019755)2.17157265
158* cilium or flagellum-dependent cell motility (GO:0001539)17.9731183
159axonemal dynein complex assembly (GO:0070286)13.9277434
160cilium movement (GO:0003341)13.3121728
161epithelial cilium movement (GO:0003351)11.5692834
162epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)10.1356529

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse5.92129240
2EZH2_22144423_ChIP-Seq_EOC_Human5.46459467
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.65306363
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.33886499
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.29811578
6FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.23417869
7CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.19853203
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.17401331
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.08202771
10ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.07716290
11AR_21572438_ChIP-Seq_LNCaP_Human2.02486821
12PCGF2_27294783_Chip-Seq_ESCs_Mouse1.97709576
13IGF1R_20145208_ChIP-Seq_DFB_Human1.91716434
14AHR_22903824_ChIP-Seq_MCF-7_Human1.83898046
15FUS_26573619_Chip-Seq_HEK293_Human1.83745792
16PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.81019527
17PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.79389614
18HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.79283912
19GATA1_26923725_Chip-Seq_HPCs_Mouse1.75158831
20CTBP2_25329375_ChIP-Seq_LNCAP_Human1.70735081
21FOXM1_26456572_ChIP-Seq_MCF-7_Human1.69169832
22EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.68166574
23PCGF2_27294783_Chip-Seq_NPCs_Mouse1.66899591
24CBX2_27304074_Chip-Seq_ESCs_Mouse1.66265940
25ZNF217_24962896_ChIP-Seq_MCF-7_Human1.64125612
26ZFP57_27257070_Chip-Seq_ESCs_Mouse1.62252838
27SUZ12_27294783_Chip-Seq_NPCs_Mouse1.61232756
28TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.60086339
29NFE2_27457419_Chip-Seq_LIVER_Mouse1.54533500
30GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.53762739
31SMAD4_21799915_ChIP-Seq_A2780_Human1.52942148
32REST_21632747_ChIP-Seq_MESCs_Mouse1.51947160
33TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.48246717
34CDX2_19796622_ChIP-Seq_MESCs_Mouse1.47485382
35ZNF274_21170338_ChIP-Seq_K562_Hela1.46210490
36TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.45676102
37TP53_18474530_ChIP-ChIP_U2OS_Human1.45573237
38WDR5_24793694_ChIP-Seq_LNCAP_Human1.42961763
39RNF2_27304074_Chip-Seq_NSC_Mouse1.42682670
40NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.41803502
41ELK4_26923725_Chip-Seq_MESODERM_Mouse1.41755198
42TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.41205665
43TP53_16413492_ChIP-PET_HCT116_Human1.39659026
44DROSHA_22980978_ChIP-Seq_HELA_Human1.39612585
45NANOG_18555785_Chip-Seq_ESCs_Mouse1.36677652
46ESR1_20079471_ChIP-ChIP_T-47D_Human1.36504484
47TAL1_26923725_Chip-Seq_HPCs_Mouse1.36426983
48EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.35054938
49MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.35040679
50SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.34991578
51AR_25329375_ChIP-Seq_VCAP_Human1.34241524
52* TCF4_22108803_ChIP-Seq_LS180_Human1.33582996
53KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.33356951
54IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.33211866
55CBP_20019798_ChIP-Seq_JUKART_Human1.33211866
56RUNX2_22187159_ChIP-Seq_PCA_Human1.32454386
57ER_23166858_ChIP-Seq_MCF-7_Human1.32400522
58RBPJ_22232070_ChIP-Seq_NCS_Mouse1.30321728
59MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.30067661
60TP63_23658742_ChIP-Seq_EP156T_Human1.29242546
61TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29057577
62POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.29057577
63CTNNB1_20460455_ChIP-Seq_HCT116_Human1.28841142
64EZH2_27294783_Chip-Seq_NPCs_Mouse1.28383748
65VDR_22108803_ChIP-Seq_LS180_Human1.28369379
66KDM2B_26808549_Chip-Seq_REH_Human1.26292448
67ETV1_20927104_ChIP-Seq_GIST48_Human1.24336129
68TCF4_23295773_ChIP-Seq_U87_Human1.24326333
69SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23756833
70CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23567396
71* BCAT_22108803_ChIP-Seq_LS180_Human1.22743981
72SALL1_21062744_ChIP-ChIP_HESCs_Human1.22466029
73GBX2_23144817_ChIP-Seq_PC3_Human1.22150388
74EWS_26573619_Chip-Seq_HEK293_Human1.22099505
75P53_22387025_ChIP-Seq_ESCs_Mouse1.21246834
76OCT4_18555785_Chip-Seq_ESCs_Mouse1.20314981
77STAT3_23295773_ChIP-Seq_U87_Human1.19319579
78EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.17864875
79* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.17589500
80FLI1_21867929_ChIP-Seq_TH2_Mouse1.17576987
81P300_18555785_Chip-Seq_ESCs_Mouse1.16992078
82TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.16708654
83SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.16678777
84SMRT_27268052_Chip-Seq_Bcells_Human1.16271462
85* PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.15255011
86PRDM14_20953172_ChIP-Seq_ESCs_Human1.14899220
87STAT1_17558387_ChIP-Seq_HELA_Human1.14730443
88SMAD4_21741376_ChIP-Seq_EPCs_Human1.14680316
89STAT3_18555785_Chip-Seq_ESCs_Mouse1.14487991
90PHF8_20622853_ChIP-Seq_HELA_Human1.14197790
91CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.13685135
92E2F1_18555785_Chip-Seq_ESCs_Mouse1.13379878
93SMAD3_21741376_ChIP-Seq_HESCs_Human1.13070893
94SOX2_21211035_ChIP-Seq_LN229_Gbm1.13002946
95CRX_20693478_ChIP-Seq_RETINA_Mouse1.12841234
96SMAD3_21741376_ChIP-Seq_EPCs_Human1.12624437
97EZH2_27294783_Chip-Seq_ESCs_Mouse1.12275540
98* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.12192196
99CMYC_18555785_Chip-Seq_ESCs_Mouse1.12002223
100POU3F2_20337985_ChIP-ChIP_501MEL_Human1.11838532
101NFYA_21822215_ChIP-Seq_K562_Human1.11572034
102EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.10947166
103NFYB_21822215_ChIP-Seq_K562_Human1.10857467
104OCT4_21477851_ChIP-Seq_ESCs_Mouse1.10853561
105CTBP1_25329375_ChIP-Seq_LNCAP_Human1.10702496
106* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.10692479
107SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.10538779
108OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10531474
109TOP2B_26459242_ChIP-Seq_MCF-7_Human1.09936136
110ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.08787606
111CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.08460488
112KAP1_22055183_ChIP-Seq_ESCs_Mouse1.08455755
113NR3C1_21868756_ChIP-Seq_MCF10A_Human1.08157797
114GF1_26923725_Chip-Seq_HPCs_Mouse1.06229218
115SUZ12_18555785_Chip-Seq_ESCs_Mouse1.05902713
116KLF5_20875108_ChIP-Seq_MESCs_Mouse1.05841029
117AR_19668381_ChIP-Seq_PC3_Human1.05564812
118CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.05391251
119HNFA_21074721_ChIP-Seq_CACO-2_Human1.04955822
120SUZ12_27294783_Chip-Seq_ESCs_Mouse1.04872053
121SOX2_18555785_Chip-Seq_ESCs_Mouse1.04162963
122TBL1_22424771_ChIP-Seq_293T_Human1.03980243
123RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.03545666
124GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.03272771
125SMAD4_21741376_ChIP-Seq_HESCs_Human1.03232572
126P300_19829295_ChIP-Seq_ESCs_Human1.03199039
127TAF15_26573619_Chip-Seq_HEK293_Human1.03160496
128PU1_27457419_Chip-Seq_LIVER_Mouse1.03024995
129ESRRB_18555785_Chip-Seq_ESCs_Mouse1.02565460
130KLF4_18555785_Chip-Seq_ESCs_Mouse1.02332209
131STAT6_21828071_ChIP-Seq_BEAS2B_Human1.01748777
132ZFX_18555785_Chip-Seq_ESCs_Mouse1.01702742
133FOXA1_25552417_ChIP-Seq_VCAP_Human1.01489777
134CBX2_22325352_ChIP-Seq_293T-Rex_Human0.99694683
135RUNX1_27457419_Chip-Seq_LIVER_Mouse0.99144450
136* CDX2_22108803_ChIP-Seq_LS180_Human0.98169064
137NANOG_19829295_ChIP-Seq_ESCs_Human0.98023582
138SOX2_19829295_ChIP-Seq_ESCs_Human0.98023582
139CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.97795369
140MTF2_20144788_ChIP-Seq_MESCs_Mouse0.96278791
141ARNT_22903824_ChIP-Seq_MCF-7_Human0.96099697
142PIAS1_25552417_ChIP-Seq_VCAP_Human0.95608694
143LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95401776
144SMAD3_21741376_ChIP-Seq_ESCs_Human0.94270509
145PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.94234167
146CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.94129913
147CTCF_18555785_Chip-Seq_ESCs_Mouse0.93192641
148UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.92798508

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002653_abnormal_ependyma_morphology4.91774516
2MP0005623_abnormal_meninges_morphology4.77574057
3MP0003698_abnormal_male_reproductive4.70747897
4MP0008875_abnormal_xenobiotic_pharmacok4.51520683
5MP0001929_abnormal_gametogenesis4.18993706
6MP0008877_abnormal_DNA_methylation3.98672779
7MP0004043_abnormal_pH_regulation3.29506062
8MP0002210_abnormal_sex_determination2.95385756
9MP0003136_yellow_coat_color2.77728422
10MP0009046_muscle_twitch2.71312375
11MP0000383_abnormal_hair_follicle2.66048200
12MP0009780_abnormal_chondrocyte_physiolo2.58035328
13MP0002161_abnormal_fertility/fecundity2.49934218
14MP0001145_abnormal_male_reproductive2.33933271
15MP0002277_abnormal_respiratory_mucosa2.25750109
16MP0005167_abnormal_blood-brain_barrier2.23856714
17MP0000566_synostosis2.16354010
18MP0001485_abnormal_pinna_reflex2.13734461
19MP0000653_abnormal_sex_gland2.11835873
20MP0008789_abnormal_olfactory_epithelium2.10549818
21MP0008004_abnormal_stomach_pH2.05279789
22MP0005410_abnormal_fertilization11.1574087
23MP0010678_abnormal_skin_adnexa1.96432405
24MP0002160_abnormal_reproductive_system1.90956263
25MP0002282_abnormal_trachea_morphology1.83805141
26MP0003950_abnormal_plasma_membrane1.76934160
27MP0008995_early_reproductive_senescence1.65086345
28MP0005083_abnormal_biliary_tract1.50763791
29MP0003880_abnormal_central_pattern1.49754866
30MP0004859_abnormal_synaptic_plasticity1.49494841
31MP0005499_abnormal_olfactory_system1.47606830
32MP0005394_taste/olfaction_phenotype1.47606830
33MP0001879_abnormal_lymphatic_vessel1.40058024
34MP0001440_abnormal_grooming_behavior1.39546510
35MP0001851_eye_inflammation1.39136614
36MP0010368_abnormal_lymphatic_system1.38102133
37MP0005085_abnormal_gallbladder_physiolo1.34919891
38MP0001984_abnormal_olfaction1.34005491
39MP0005248_abnormal_Harderian_gland1.33902301
40MP0010386_abnormal_urinary_bladder1.33465895
41MP0003724_increased_susceptibility_to1.33427069
42MP0004133_heterotaxia1.32663838
43MP0000026_abnormal_inner_ear1.31030910
44MP0002928_abnormal_bile_duct1.29900650
45MP0001346_abnormal_lacrimal_gland1.29459339
46MP0005647_abnormal_sex_gland1.27719640
47MP0005388_respiratory_system_phenotype1.26182304
48MP0002133_abnormal_respiratory_system1.26182304
49MP0005646_abnormal_pituitary_gland1.25877780
50MP0000631_abnormal_neuroendocrine_gland1.23159910
51MP0009745_abnormal_behavioral_response1.22768273
52MP0003635_abnormal_synaptic_transmissio1.18495418
53MP0005423_abnormal_somatic_nervous1.14789379
54MP0002876_abnormal_thyroid_physiology1.10509651
55MP0002233_abnormal_nose_morphology1.09607270
56MP0001958_emphysema1.08550604
57MP0003690_abnormal_glial_cell1.05316582
58MP0005195_abnormal_posterior_eye1.05129918
59MP0001324_abnormal_eye_pigmentation1.03953178
60MP0002229_neurodegeneration1.03619159
61MP0002572_abnormal_emotion/affect_behav1.03291805
62MP0001765_abnormal_ion_homeostasis1.02403383
63MP0000427_abnormal_hair_cycle1.01791896
64MP0003633_abnormal_nervous_system1.00069741
65MP0005395_other_phenotype0.99399609
66MP0000778_abnormal_nervous_system0.98147239
67MP0005391_vision/eye_phenotype0.96939114
68MP0001970_abnormal_pain_threshold0.96837222
69MP0002063_abnormal_learning/memory/cond0.96598249
70MP0008057_abnormal_DNA_replication0.96278796
71MP0001968_abnormal_touch/_nociception0.96085036
72MP0005389_reproductive_system_phenotype0.95015880
73MP0003195_calcinosis0.94187212
74MP0002064_seizures0.93922938
75MP0000569_abnormal_digit_pigmentation0.93723558
76MP0002249_abnormal_larynx_morphology0.93691457
77MP0004782_abnormal_surfactant_physiolog0.92904196
78MP0002132_abnormal_respiratory_system0.92143970
79MP0001299_abnormal_eye_distance/0.91332494
80MP0001501_abnormal_sleep_pattern0.88848470
81MP0001486_abnormal_startle_reflex0.87975886
82MP0004270_analgesia0.86222190
83MP0001177_atelectasis0.86161819
84MP0005645_abnormal_hypothalamus_physiol0.85513087
85MP0005551_abnormal_eye_electrophysiolog0.84641551
86MP0002736_abnormal_nociception_after0.84158754
87MP0003937_abnormal_limbs/digits/tail_de0.83396906
88MP0005365_abnormal_bile_salt0.83321682
89MP0003656_abnormal_erythrocyte_physiolo0.82230693
90MP0002272_abnormal_nervous_system0.80117571
91MP0001293_anophthalmia0.79670186
92MP0010030_abnormal_orbit_morphology0.78926729
93MP0005636_abnormal_mineral_homeostasis0.78644809
94MP0003890_abnormal_embryonic-extraembry0.77109451
95MP0005310_abnormal_salivary_gland0.75572487
96MP0003634_abnormal_glial_cell0.75487654
97MP0006072_abnormal_retinal_apoptosis0.75327512
98MP0002734_abnormal_mechanical_nocicepti0.74790837
99MP0003252_abnormal_bile_duct0.74762694
100MP0005187_abnormal_penis_morphology0.74732998
101MP0002557_abnormal_social/conspecific_i0.73969560
102MP0003631_nervous_system_phenotype0.71089758
103MP0002752_abnormal_somatic_nervous0.70798671
104MP0004885_abnormal_endolymph0.69815901
105MP0002822_catalepsy0.69815062
106MP0004142_abnormal_muscle_tone0.69434036
107MP0004858_abnormal_nervous_system0.68106159
108MP0004272_abnormal_basement_membrane0.67795762
109MP0003045_fibrosis0.66560756
110MP0003878_abnormal_ear_physiology0.66420602
111MP0005377_hearing/vestibular/ear_phenot0.66420602
112MP0002909_abnormal_adrenal_gland0.65131375
113MP0005595_abnormal_vascular_smooth0.64763292
114MP0002152_abnormal_brain_morphology0.64532204
115MP0005220_abnormal_exocrine_pancreas0.64227408
116MP0005670_abnormal_white_adipose0.63323410
117MP0008872_abnormal_physiological_respon0.63268238
118MP0002295_abnormal_pulmonary_circulatio0.61836660
119MP0001502_abnormal_circadian_rhythm0.60489000
120MP0006054_spinal_hemorrhage0.60084582
121MP0005409_darkened_coat_color0.59537099
122MP0005253_abnormal_eye_physiology0.58367125
123MP0002254_reproductive_system_inflammat0.57964993
124MP0003329_amyloid_beta_deposits0.56832389
125MP0004883_abnormal_blood_vessel0.56458742
126MP0002067_abnormal_sensory_capabilities0.54367193
127MP0004484_altered_response_of0.54062873
128MP0006276_abnormal_autonomic_nervous0.53893019
129MP0000013_abnormal_adipose_tissue0.51498968
130MP0003861_abnormal_nervous_system0.51285365
131MP0002735_abnormal_chemical_nociception0.51268840
132MP0006138_congestive_heart_failure0.51004371
133MP0002638_abnormal_pupillary_reflex0.50598086
134MP0003879_abnormal_hair_cell0.49569408
135MP0003115_abnormal_respiratory_system0.48748990
136MP0004742_abnormal_vestibular_system0.47114636
137MP0000955_abnormal_spinal_cord0.46701839
138MP0002168_other_aberrant_phenotype0.46198573
139MP0003646_muscle_fatigue0.46158449
140MP0008569_lethality_at_weaning0.45090737
141MP0003786_premature_aging0.42940326
142MP0002882_abnormal_neuron_morphology0.42633155
143MP0002102_abnormal_ear_morphology0.42465146
144MP0005164_abnormal_response_to0.42115854
145MP0004811_abnormal_neuron_physiology0.41696375
146MP0001963_abnormal_hearing_physiology0.39493518
147MP0004019_abnormal_vitamin_homeostasis0.39223424
148MP0004134_abnormal_chest_morphology0.39162410

Predicted human phenotypes

RankGene SetZ-score
1Rhinitis (HP:0012384)9.46246850
2Abnormal respiratory motile cilium morphology (HP:0005938)9.29745486
3Abnormal respiratory epithelium morphology (HP:0012253)9.29745486
4Chronic bronchitis (HP:0004469)7.50134721
5Nasal polyposis (HP:0100582)5.91274690
6Bronchiectasis (HP:0002110)5.70531441
7Abnormality of the nasal mucosa (HP:0000433)5.35401710
8Infertility (HP:0000789)4.96641867
9Bronchitis (HP:0012387)4.35481002
10Nephronophthisis (HP:0000090)4.11669696
11Recurrent sinusitis (HP:0011108)3.50934650
12Abnormality of the renal medulla (HP:0100957)3.21946497
13Tubulointerstitial nephritis (HP:0001970)3.15019280
14Recurrent otitis media (HP:0000403)3.00665781
15Chronic sinusitis (HP:0011109)2.99018097
16Medial flaring of the eyebrow (HP:0010747)2.77606593
17Molar tooth sign on MRI (HP:0002419)2.73382816
18Abnormality of midbrain morphology (HP:0002418)2.73382816
19Pancreatic fibrosis (HP:0100732)2.71175298
20Male infertility (HP:0003251)2.68607470
21Abnormality of the lower motor neuron (HP:0002366)2.66466001
22Chronic otitis media (HP:0000389)2.64938050
23Median cleft lip (HP:0000161)2.56381070
24Absent rod-and cone-mediated responses on ERG (HP:0007688)2.49711002
25Fibular hypoplasia (HP:0003038)2.48602668
26Postaxial foot polydactyly (HP:0001830)2.42276989
27Tubulointerstitial abnormality (HP:0001969)2.40271235
28Congenital hepatic fibrosis (HP:0002612)2.35107062
29True hermaphroditism (HP:0010459)2.34556567
30Tubular atrophy (HP:0000092)2.26074413
31Recurrent bronchitis (HP:0002837)2.25711856
32Amyotrophic lateral sclerosis (HP:0007354)2.25218057
33Hyperactive renin-angiotensin system (HP:0000841)2.24909546
34Supernumerary spleens (HP:0009799)2.16933919
35Abnormality of dentin (HP:0010299)2.14784790
36Gait imbalance (HP:0002141)2.11668366
37Stage 5 chronic kidney disease (HP:0003774)2.10905641
38Congenital primary aphakia (HP:0007707)2.08155959
39Abnormality of permanent molar morphology (HP:0011071)2.03264782
40Abnormality of the dental root (HP:0006486)2.03264782
41Taurodontia (HP:0000679)2.03264782
42Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.8237614
43Abnormal respiratory motile cilium physiology (HP:0012261)11.4027714
44Absent/shortened dynein arms (HP:0200106)10.5972688
45Dynein arm defect of respiratory motile cilia (HP:0012255)10.5972688
46Abnormal ciliary motility (HP:0012262)10.5193807
47Sclerocornea (HP:0000647)1.99436317
48Tubulointerstitial fibrosis (HP:0005576)1.93957325
49Abnormality of molar (HP:0011077)1.93326270
50Abnormality of molar morphology (HP:0011070)1.93326270
51Aplasia/Hypoplasia of the tongue (HP:0010295)1.93010410
52Furrowed tongue (HP:0000221)1.88414358
53Abnormal rod and cone electroretinograms (HP:0008323)1.87873323
54Cystic liver disease (HP:0006706)1.87245679
55Abnormality of the dental pulp (HP:0006479)1.86887857
56Postaxial hand polydactyly (HP:0001162)1.80039740
57Facial cleft (HP:0002006)1.79983422
58Oculomotor apraxia (HP:0000657)1.79170788
59Nephrogenic diabetes insipidus (HP:0009806)1.77466436
60Decreased circulating renin level (HP:0003351)1.74437750
61Genital tract atresia (HP:0001827)1.71598245
62Microglossia (HP:0000171)1.71007292
63Occipital encephalocele (HP:0002085)1.68657363
64Abnormal biliary tract physiology (HP:0012439)1.66774728
65Bile duct proliferation (HP:0001408)1.66774728
66J-shaped sella turcica (HP:0002680)1.66269743
67Cone-rod dystrophy (HP:0000548)1.64329239
68Impaired proprioception (HP:0010831)1.60873324
69Pancreatic cysts (HP:0001737)1.60337838
70Upper motor neuron abnormality (HP:0002127)1.58971386
71Aplasia/Hypoplasia of the fibula (HP:0006492)1.58956068
72Short ribs (HP:0000773)1.58077768
73Vaginal atresia (HP:0000148)1.54815189
74Abnormality of the renal cortex (HP:0011035)1.53722109
75Poor coordination (HP:0002370)1.51486960
76Bony spicule pigmentary retinopathy (HP:0007737)1.50842510
77Gonadotropin excess (HP:0000837)1.50443422
78Aplasia/Hypoplasia of the spleen (HP:0010451)1.47001145
79Asplenia (HP:0001746)1.45660536
80Gaze-evoked nystagmus (HP:0000640)1.44720421
81Decreased central vision (HP:0007663)1.44501478
82Nephropathy (HP:0000112)1.41137491
83Polydipsia (HP:0001959)1.41073800
84Abnormal drinking behavior (HP:0030082)1.41073800
85Absent frontal sinuses (HP:0002688)1.40311402
86Aplasia/Hypoplasia of the lens (HP:0008063)1.36208176
87Chronic hepatic failure (HP:0100626)1.36087306
88Renal salt wasting (HP:0000127)1.35825615
89Preaxial hand polydactyly (HP:0001177)1.35233632
90Conjunctival telangiectasia (HP:0000524)1.34805052
9111 pairs of ribs (HP:0000878)1.34671467
92Short thorax (HP:0010306)1.34342998
93Retinitis pigmentosa (HP:0000510)1.32661509
94Abnormality of ocular smooth pursuit (HP:0000617)1.31683035
95Bell-shaped thorax (HP:0001591)1.30635964
96Narrow forehead (HP:0000341)1.30413424
97Abnormal spermatogenesis (HP:0008669)1.29877671
98Broad distal phalanx of finger (HP:0009836)1.29738512
99Prominent nasal bridge (HP:0000426)1.27567386
100Abnormality of macular pigmentation (HP:0008002)1.27305521
101Portal hypertension (HP:0001409)1.27099054
102Atelectasis (HP:0100750)1.26346553
103Renal dysplasia (HP:0000110)1.25182528
104Hyperaldosteronism (HP:0000859)1.24560828
105Azoospermia (HP:0000027)1.21922827
106Male pseudohermaphroditism (HP:0000037)1.21900465
107Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.21877912
108Hypodontia (HP:0000668)1.20271148
109Decreased motor nerve conduction velocity (HP:0003431)1.19267152
110Abnormality of renal excretion (HP:0011036)1.18231448
111Broad foot (HP:0001769)1.18155329
112Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.17985656
113Polycystic kidney dysplasia (HP:0000113)1.17058632
114Abnormality of renin-angiotensin system (HP:0000847)1.16959854
115Narrow chest (HP:0000774)1.16876987
116Aganglionic megacolon (HP:0002251)1.15926346
117Hemiparesis (HP:0001269)1.14870076
118Abnormality of the hepatic vasculature (HP:0006707)1.14729897
119Multicystic kidney dysplasia (HP:0000003)1.14282341
120Anencephaly (HP:0002323)1.12746132
121Hypoplasia of the capital femoral epiphysis (HP:0003090)1.12386385
122Abnormality of chloride homeostasis (HP:0011422)1.12194219
123Bifid scrotum (HP:0000048)1.11807634
124Polyuria (HP:0000103)1.11469285
125Neurofibrillary tangles (HP:0002185)1.11361173
126Hyperkalemia (HP:0002153)1.10990077
127Progressive cerebellar ataxia (HP:0002073)1.09887011
128Constricted visual fields (HP:0001133)1.08416403
129Hypokalemic alkalosis (HP:0001949)1.07924880
130Specific learning disability (HP:0001328)1.07573584
131Hypoplasia of dental enamel (HP:0006297)1.07553547
132Intellectual disability, moderate (HP:0002342)1.06890303
133Highly arched eyebrow (HP:0002553)1.06834791

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK47.62627655
2PDK37.62627655
3PDK25.45860134
4PNCK4.80481333
5MAPK154.44220998
6FRK3.89168146
7PTK2B2.93650632
8PRKD32.74079985
9TESK12.55043728
10EPHA22.41508292
11STK392.26110736
12WNK42.16170290
13TIE12.15942473
14MAP4K21.95939547
15MAP3K21.76955154
16ICK1.69900956
17LMTK21.56366250
18MAPK131.51291572
19WNK31.50891401
20NTRK21.50219626
21ERBB31.43908132
22MAPKAPK31.42111838
23EPHA31.36084316
24CASK1.34673921
25WNK11.34006740
26INSRR1.21743131
27GRK11.18251870
28STK241.12458256
29ADRBK21.09210262
30STK381.05839723
31ERBB21.03201366
32STK31.02117366
33EPHA41.01461173
34MAP3K71.00760069
35NLK1.00151482
36NEK20.97443107
37NME10.95284572
38TLK10.94112350
39CAMK1G0.92091171
40RIPK40.88114555
41TSSK60.87450419
42PINK10.84638521
43TNIK0.81672371
44MAP3K40.81051040
45OXSR10.81009491
46TYRO30.78308391
47NTRK30.78088715
48MET0.74839578
49BRSK20.72861947
50TRPM70.72714016
51NEK60.70984737
52PDK10.68315961
53IRAK10.67797694
54DAPK20.64892466
55TGFBR20.63644057
56MAPKAPK50.62032402
57FER0.61019760
58CAMKK10.59742340
59BRD40.58304938
60ACVR1B0.55866870
61MAP2K70.54780809
62PRKCG0.53726231
63ADRBK10.53122453
64MARK20.51632833
65SGK10.50993273
66WEE10.49783242
67CAMKK20.49757352
68EEF2K0.49258213
69MAP3K120.48294538
70PAK30.47879944
71MARK10.46735462
72MST40.46068629
73PAK20.45325227
74STK160.44625052
75PAK60.44379661
76BMPR1B0.44132613
77MST1R0.43403299
78PRKAA20.40413807
79LATS20.38178016
80PLK40.36264772
81CAMK2A0.36054221
82MKNK20.35879091
83PRKCI0.35705481
84KDR0.35321641
85CSNK1G20.35319092
86EPHB20.35236851
87PKN10.33531617
88PRKG10.32725744
89MINK10.31955827
90GRK50.31708927
91STK110.31263423
92PRKCQ0.31215161
93CDK30.31210208
94CDK50.30512528
95AKT30.30087102
96DYRK1B0.29198987
97MAP3K30.29023404
98PTK60.27795680
99CSNK1A1L0.27101219
100PTK20.27084969
101DYRK30.26863890
102PDPK10.26470550
103PRKCA0.26297096
104LATS10.25611433
105CCNB10.25593354
106NEK90.25539806
107RIPK10.25447138
108SGK30.24476458
109BCR0.24370211
110FES0.23346635
111BMPR20.21006443
112EGFR0.20485529
113CSK0.20000364
114GSK3A0.19808886
115MAPK100.18586959
116STK100.18213462
117ROCK20.18174238
118TTK0.17906967
119SGK20.17784517
120NTRK10.17033321
121PRKCE0.17008789
122SGK2230.16871522
123SGK4940.16871522
124STK38L0.16670053
125ROCK10.16620403
126EPHB10.15237798
127PLK20.15143631
128MAP3K90.14628552
129SRC0.14110046
130FGFR20.14035449
131ATM0.13705796
132TEC0.13468681
133IRAK20.13418931
134PRKCZ0.13287540
135PRKCH0.12758635
136RPS6KA30.12186555
137MUSK0.12013413
138RPS6KA20.11591393
139PRKAA10.11561141
140PRKACG0.11515793
141PRKACA0.11334136
142FGR0.10574807
143ABL10.10280806
144DYRK1A0.09888737
145MAP2K40.09826023
146CDC42BPA0.09146017
147CAMK2B0.09001753

Predicted pathways (KEGG)

RankGene SetZ-score
1Chemical carcinogenesis_Homo sapiens_hsa052043.62128331
2Histidine metabolism_Homo sapiens_hsa003403.54805343
3Vitamin B6 metabolism_Homo sapiens_hsa007503.31004815
4Phenylalanine metabolism_Homo sapiens_hsa003602.97106980
5Dorso-ventral axis formation_Homo sapiens_hsa043202.89242288
6beta-Alanine metabolism_Homo sapiens_hsa004102.52986860
7Tyrosine metabolism_Homo sapiens_hsa003502.41225350
8Retinol metabolism_Homo sapiens_hsa008302.35524191
9Amphetamine addiction_Homo sapiens_hsa050312.31355293
10Renin secretion_Homo sapiens_hsa049242.29659969
11Primary bile acid biosynthesis_Homo sapiens_hsa001202.19794833
12Caffeine metabolism_Homo sapiens_hsa002322.16519724
13Nicotine addiction_Homo sapiens_hsa050331.95957617
14Huntingtons disease_Homo sapiens_hsa050161.94764611
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.86178820
16Steroid hormone biosynthesis_Homo sapiens_hsa001401.83608872
17Pyruvate metabolism_Homo sapiens_hsa006201.82726859
18Glucagon signaling pathway_Homo sapiens_hsa049221.80482402
19Long-term potentiation_Homo sapiens_hsa047201.76921007
20Taste transduction_Homo sapiens_hsa047421.75825147
21Glutamatergic synapse_Homo sapiens_hsa047241.70718839
22Olfactory transduction_Homo sapiens_hsa047401.69709724
23Salivary secretion_Homo sapiens_hsa049701.69690623
24Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.65081864
25Circadian entrainment_Homo sapiens_hsa047131.65034156
26Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.64158900
27Butanoate metabolism_Homo sapiens_hsa006501.56339892
28Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.54761513
29Propanoate metabolism_Homo sapiens_hsa006401.53397759
30Fatty acid biosynthesis_Homo sapiens_hsa000611.51613785
31Gastric acid secretion_Homo sapiens_hsa049711.51504611
32Estrogen signaling pathway_Homo sapiens_hsa049151.50519673
33Mineral absorption_Homo sapiens_hsa049781.49040333
34Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.47760638
35Morphine addiction_Homo sapiens_hsa050321.47436686
36Calcium signaling pathway_Homo sapiens_hsa040201.47232448
37Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.46928708
38Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.46238960
39Glutathione metabolism_Homo sapiens_hsa004801.44096815
40Oocyte meiosis_Homo sapiens_hsa041141.43641889
41Fatty acid degradation_Homo sapiens_hsa000711.39609232
42Fanconi anemia pathway_Homo sapiens_hsa034601.39015789
43Peroxisome_Homo sapiens_hsa041461.34780891
44Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.28405434
45Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.23096147
46Insulin secretion_Homo sapiens_hsa049111.21206333
47GABAergic synapse_Homo sapiens_hsa047271.20922810
48Glycerolipid metabolism_Homo sapiens_hsa005611.20751040
49Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.17528397
50Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.17399283
51cGMP-PKG signaling pathway_Homo sapiens_hsa040221.14213581
52cAMP signaling pathway_Homo sapiens_hsa040241.10742591
53Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.08529788
54alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.08116320
55Ether lipid metabolism_Homo sapiens_hsa005651.06179638
56Tryptophan metabolism_Homo sapiens_hsa003801.06175622
57Basal transcription factors_Homo sapiens_hsa030221.06025630
58Aldosterone synthesis and secretion_Homo sapiens_hsa049251.05601208
59Synaptic vesicle cycle_Homo sapiens_hsa047211.05497827
60Vascular smooth muscle contraction_Homo sapiens_hsa042701.05327630
61Phosphatidylinositol signaling system_Homo sapiens_hsa040701.04677124
62Cocaine addiction_Homo sapiens_hsa050301.04524204
63Carbohydrate digestion and absorption_Homo sapiens_hsa049731.03677078
64Cardiac muscle contraction_Homo sapiens_hsa042601.01905678
65Pentose phosphate pathway_Homo sapiens_hsa000301.01100723
66Ovarian steroidogenesis_Homo sapiens_hsa049131.00701534
67Pancreatic secretion_Homo sapiens_hsa049721.00687923
68Dopaminergic synapse_Homo sapiens_hsa047280.99654943
69Oxytocin signaling pathway_Homo sapiens_hsa049210.99636668
70Linoleic acid metabolism_Homo sapiens_hsa005910.96415071
71Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.96316049
72Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.95567188
73Glycerophospholipid metabolism_Homo sapiens_hsa005640.95201150
74Thyroid hormone synthesis_Homo sapiens_hsa049180.92871581
75Arachidonic acid metabolism_Homo sapiens_hsa005900.92551183
76Pentose and glucuronate interconversions_Homo sapiens_hsa000400.90584303
77Nitrogen metabolism_Homo sapiens_hsa009100.90143705
78Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.89453694
79Collecting duct acid secretion_Homo sapiens_hsa049660.86251499
80PPAR signaling pathway_Homo sapiens_hsa033200.79889649
81Starch and sucrose metabolism_Homo sapiens_hsa005000.78417793
82Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.78375043
83Glycosaminoglycan degradation_Homo sapiens_hsa005310.77039083
84Maturity onset diabetes of the young_Homo sapiens_hsa049500.76605789
85Axon guidance_Homo sapiens_hsa043600.76371619
86Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.75684613
87Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.75113879
88Melanogenesis_Homo sapiens_hsa049160.71354330
89Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.70213547
90Antigen processing and presentation_Homo sapiens_hsa046120.68455070
91Wnt signaling pathway_Homo sapiens_hsa043100.67647447
92Tight junction_Homo sapiens_hsa045300.67627231
93ABC transporters_Homo sapiens_hsa020100.67292113
94Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.67122431
95Inositol phosphate metabolism_Homo sapiens_hsa005620.66804185
96Hedgehog signaling pathway_Homo sapiens_hsa043400.66611480
97Bile secretion_Homo sapiens_hsa049760.65111997
98Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.62125880
99GnRH signaling pathway_Homo sapiens_hsa049120.59816167
100VEGF signaling pathway_Homo sapiens_hsa043700.58604251
101Serotonergic synapse_Homo sapiens_hsa047260.58027884
102Phototransduction_Homo sapiens_hsa047440.57617393
103Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.57168637
104Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.56900157
105Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.56287287
106Sphingolipid metabolism_Homo sapiens_hsa006000.55739663
107Salmonella infection_Homo sapiens_hsa051320.55335389
108Long-term depression_Homo sapiens_hsa047300.54427306
109MAPK signaling pathway_Homo sapiens_hsa040100.54287072
110Cholinergic synapse_Homo sapiens_hsa047250.53232052
111Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.53111405
112Complement and coagulation cascades_Homo sapiens_hsa046100.52689668
113Gap junction_Homo sapiens_hsa045400.52191176
114Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.48863933
115Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.48566532
116Hippo signaling pathway_Homo sapiens_hsa043900.48144520
117Purine metabolism_Homo sapiens_hsa002300.48054130
118Dilated cardiomyopathy_Homo sapiens_hsa054140.47007869
119Adherens junction_Homo sapiens_hsa045200.45921448
120Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.44946774
121Endocytosis_Homo sapiens_hsa041440.43021723
122African trypanosomiasis_Homo sapiens_hsa051430.42694936
123Phospholipase D signaling pathway_Homo sapiens_hsa040720.42640784
124Choline metabolism in cancer_Homo sapiens_hsa052310.42638581
125Rap1 signaling pathway_Homo sapiens_hsa040150.42290750
126Circadian rhythm_Homo sapiens_hsa047100.41840014
127Notch signaling pathway_Homo sapiens_hsa043300.41021654
128Basal cell carcinoma_Homo sapiens_hsa052170.40406708
129Drug metabolism - other enzymes_Homo sapiens_hsa009830.40392752
130ECM-receptor interaction_Homo sapiens_hsa045120.39266838
131Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.38018915
132Regulation of autophagy_Homo sapiens_hsa041400.37982471
133Metabolic pathways_Homo sapiens_hsa011000.36960939
134Phagosome_Homo sapiens_hsa041450.36807889
135Leukocyte transendothelial migration_Homo sapiens_hsa046700.36381799
136Arginine and proline metabolism_Homo sapiens_hsa003300.35115090
137Transcriptional misregulation in cancer_Homo sapiens_hsa052020.35049007
138Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.28887753
139Alcoholism_Homo sapiens_hsa050340.28779240
140Steroid biosynthesis_Homo sapiens_hsa001000.23710607
141Type II diabetes mellitus_Homo sapiens_hsa049300.22145487
142Vitamin digestion and absorption_Homo sapiens_hsa049770.22004502

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