DNAH7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: DNAH7 is a component of the inner dynein arm of ciliary axonemes (Zhang et al., 2002 [PubMed 11877439]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1motile cilium assembly (GO:0044458)9.74298634
2axoneme assembly (GO:0035082)8.76636871
3regulation of cilium movement (GO:0003352)6.59514198
4ventricular system development (GO:0021591)6.06562668
5left/right axis specification (GO:0070986)5.92559436
6intraciliary transport (GO:0042073)5.86545549
7cilium organization (GO:0044782)5.83101440
8cilium assembly (GO:0042384)5.64260134
9left/right pattern formation (GO:0060972)5.39557723
10microtubule bundle formation (GO:0001578)4.97138933
11cilium morphogenesis (GO:0060271)4.82022333
12cellular component assembly involved in morphogenesis (GO:0010927)4.53874966
13protein localization to cilium (GO:0061512)4.49110794
14regulation of microtubule-based movement (GO:0060632)4.30433158
15retinal cone cell development (GO:0046549)4.12583291
16photoreceptor cell maintenance (GO:0045494)3.86594968
17* microtubule-based movement (GO:0007018)3.82563919
18cell projection assembly (GO:0030031)3.79941190
19lateral ventricle development (GO:0021670)3.62171413
20retinal rod cell development (GO:0046548)3.58906331
21one-carbon compound transport (GO:0019755)3.53368207
22nonmotile primary cilium assembly (GO:0035058)3.52637035
23determination of left/right symmetry (GO:0007368)3.47508917
24sperm motility (GO:0030317)3.45780923
25smoothened signaling pathway (GO:0007224)3.34648862
26determination of bilateral symmetry (GO:0009855)3.34045789
27centriole assembly (GO:0098534)3.32523347
28vitamin transmembrane transport (GO:0035461)3.25380966
29specification of symmetry (GO:0009799)3.25027858
30exogenous drug catabolic process (GO:0042738)3.22488366
31neural tube formation (GO:0001841)3.08279721
32protein polyglutamylation (GO:0018095)3.05739231
33negative regulation of T cell differentiation in thymus (GO:0033085)3.04468481
34diterpenoid biosynthetic process (GO:0016102)2.94992175
35primary alcohol catabolic process (GO:0034310)2.94717976
36drug catabolic process (GO:0042737)2.93709533
37centriole replication (GO:0007099)2.89569862
38response to xenobiotic stimulus (GO:0009410)2.89027228
39L-fucose catabolic process (GO:0042355)2.87157268
40fucose catabolic process (GO:0019317)2.87157268
41L-fucose metabolic process (GO:0042354)2.87157268
42spinal cord motor neuron differentiation (GO:0021522)2.78189705
43appendage development (GO:0048736)2.77195771
44limb development (GO:0060173)2.77195771
45microtubule polymerization or depolymerization (GO:0031109)2.71004014
46microtubule depolymerization (GO:0007019)2.69771487
47retinoic acid metabolic process (GO:0042573)2.67532585
48nucleoside diphosphate phosphorylation (GO:0006165)2.66012453
49behavioral response to nicotine (GO:0035095)2.65347687
50ethanol metabolic process (GO:0006067)2.64175959
51detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.63014729
52neurotransmitter metabolic process (GO:0042133)2.60003697
53photoreceptor cell development (GO:0042461)2.59919803
54organic cation transport (GO:0015695)2.59784937
55negative regulation of cytosolic calcium ion concentration (GO:0051481)2.58574402
56gamma-aminobutyric acid transport (GO:0015812)2.54731587
57cornea development in camera-type eye (GO:0061303)2.53972172
58sperm capacitation (GO:0048240)2.53657833
59cytoplasmic microtubule organization (GO:0031122)2.51066953
60lateral sprouting from an epithelium (GO:0060601)2.49645162
61glomerular epithelial cell development (GO:0072310)2.48381654
62cellular ketone body metabolic process (GO:0046950)2.47087835
63organelle assembly (GO:0070925)2.45994895
64pyrimidine-containing compound transmembrane transport (GO:0072531)2.42099139
65eye photoreceptor cell development (GO:0042462)2.41969098
66interkinetic nuclear migration (GO:0022027)2.40336148
67lung epithelium development (GO:0060428)2.38954211
68regulation of collateral sprouting (GO:0048670)2.37054932
69intra-S DNA damage checkpoint (GO:0031573)2.36909510
70piRNA metabolic process (GO:0034587)2.33773495
71inner ear receptor stereocilium organization (GO:0060122)2.31788541
72negative regulation of B cell mediated immunity (GO:0002713)2.29913568
73negative regulation of immunoglobulin mediated immune response (GO:0002890)2.29913568
74brain morphogenesis (GO:0048854)2.28322582
75neurotransmitter biosynthetic process (GO:0042136)2.28080789
76positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.27404605
77benzene-containing compound metabolic process (GO:0042537)2.26994161
78multicellular organism reproduction (GO:0032504)2.26797275
79* microtubule-based process (GO:0007017)2.26677659
80tryptophan catabolic process (GO:0006569)2.26269358
81indole-containing compound catabolic process (GO:0042436)2.26269358
82indolalkylamine catabolic process (GO:0046218)2.26269358
83regulation of interleukin-5 production (GO:0032674)2.25348305
84establishment of tissue polarity (GO:0007164)2.23213574
85establishment of planar polarity (GO:0001736)2.23213574
86negative regulation of humoral immune response (GO:0002921)2.20858242
87detection of light stimulus involved in sensory perception (GO:0050962)2.19337084
88detection of light stimulus involved in visual perception (GO:0050908)2.19337084
89positive regulation of smoothened signaling pathway (GO:0045880)2.18727756
90nucleus localization (GO:0051647)2.18523600
91neuronal action potential (GO:0019228)2.17734067
92ketone body metabolic process (GO:1902224)2.17597205
93terpenoid biosynthetic process (GO:0016114)2.16807128
94glutathione derivative biosynthetic process (GO:1901687)2.16717762
95glutathione derivative metabolic process (GO:1901685)2.16717762
96axonemal dynein complex assembly (GO:0070286)13.9511504
97* cilium or flagellum-dependent cell motility (GO:0001539)13.6930082
98* cilium movement (GO:0003341)12.3142458
99epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)12.0751051
100epithelial cilium movement (GO:0003351)10.7605213

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.19074562
2VDR_22108803_ChIP-Seq_LS180_Human2.66464870
3ZNF274_21170338_ChIP-Seq_K562_Hela2.48225348
4GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.42526550
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.38910716
6EZH2_22144423_ChIP-Seq_EOC_Human2.37448139
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.32678964
8* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.29449285
9CTBP2_25329375_ChIP-Seq_LNCAP_Human2.19537306
10PIAS1_25552417_ChIP-Seq_VCAP_Human2.19295398
11CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.08468649
12PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.04045270
13IGF1R_20145208_ChIP-Seq_DFB_Human2.01244357
14AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.98946381
15BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.98695378
16SMAD4_21799915_ChIP-Seq_A2780_Human1.96076923
17CTBP1_25329375_ChIP-Seq_LNCAP_Human1.94449946
18FLI1_27457419_Chip-Seq_LIVER_Mouse1.88212501
19TAF15_26573619_Chip-Seq_HEK293_Human1.88206185
20FUS_26573619_Chip-Seq_HEK293_Human1.88014139
21DROSHA_22980978_ChIP-Seq_HELA_Human1.87517083
22P300_19829295_ChIP-Seq_ESCs_Human1.87126677
23SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.84529054
24* STAT3_23295773_ChIP-Seq_U87_Human1.83993350
25TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.83936532
26NR3C1_21868756_ChIP-Seq_MCF10A_Human1.83891124
27PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.79458779
28TOP2B_26459242_ChIP-Seq_MCF-7_Human1.68174926
29BCAT_22108803_ChIP-Seq_LS180_Human1.67877807
30EWS_26573619_Chip-Seq_HEK293_Human1.67166702
31PCGF2_27294783_Chip-Seq_ESCs_Mouse1.65745357
32ER_23166858_ChIP-Seq_MCF-7_Human1.65672275
33AR_21572438_ChIP-Seq_LNCaP_Human1.64640692
34SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.63749830
35ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.62712230
36FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.62271756
37* TCF4_23295773_ChIP-Seq_U87_Human1.61957741
38FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.61732437
39SMAD3_21741376_ChIP-Seq_EPCs_Human1.60654615
40ARNT_22903824_ChIP-Seq_MCF-7_Human1.54922131
41AR_25329375_ChIP-Seq_VCAP_Human1.54844744
42AHR_22903824_ChIP-Seq_MCF-7_Human1.53177590
43MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.49436613
44CBP_20019798_ChIP-Seq_JUKART_Human1.46868462
45IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.46868462
46* TCF4_22108803_ChIP-Seq_LS180_Human1.45155579
47SALL1_21062744_ChIP-ChIP_HESCs_Human1.43736696
48UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.42703497
49HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.39478110
50TP53_16413492_ChIP-PET_HCT116_Human1.38877357
51TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.38655152
52POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.38655152
53FOXM1_26456572_ChIP-Seq_MCF-7_Human1.37672762
54RUNX2_22187159_ChIP-Seq_PCA_Human1.37631812
55ZNF217_24962896_ChIP-Seq_MCF-7_Human1.36640039
56SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35092900
57TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.32756865
58SMAD4_21741376_ChIP-Seq_EPCs_Human1.30271000
59* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.29313662
60OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27631734
61* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.24067085
62TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23516558
63NANOG_18555785_Chip-Seq_ESCs_Mouse1.22374942
64SUZ12_27294783_Chip-Seq_NPCs_Mouse1.22017566
65EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.20305186
66TP53_18474530_ChIP-ChIP_U2OS_Human1.19451747
67NFE2_27457419_Chip-Seq_LIVER_Mouse1.18327667
68KLF5_20875108_ChIP-Seq_MESCs_Mouse1.17195956
69BMI1_23680149_ChIP-Seq_NPCS_Mouse1.17103909
70RNF2_27304074_Chip-Seq_NSC_Mouse1.16403178
71* PRDM14_20953172_ChIP-Seq_ESCs_Human1.16144533
72CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15195979
73* SOX2_21211035_ChIP-Seq_LN229_Gbm1.14131872
74* NANOG_19829295_ChIP-Seq_ESCs_Human1.13661891
75* SOX2_19829295_ChIP-Seq_ESCs_Human1.13661891
76REST_21632747_ChIP-Seq_MESCs_Mouse1.13424514
77EZH2_27294783_Chip-Seq_NPCs_Mouse1.11699894
78SMAD3_21741376_ChIP-Seq_HESCs_Human1.11315684
79TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.08789880
80CDX2_19796622_ChIP-Seq_MESCs_Mouse1.08658212
81EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.08608477
82P53_22387025_ChIP-Seq_ESCs_Mouse1.08018672
83PCGF2_27294783_Chip-Seq_NPCs_Mouse1.07100013
84FOXA1_21572438_ChIP-Seq_LNCaP_Human1.06259434
85ETV1_20927104_ChIP-Seq_GIST48_Human1.03547946
86E2F1_18555785_Chip-Seq_ESCs_Mouse1.02841089
87TP53_22573176_ChIP-Seq_HFKS_Human1.02740751
88TAL1_26923725_Chip-Seq_HPCs_Mouse1.02533545
89* CDX2_22108803_ChIP-Seq_LS180_Human1.02403530
90FOXA1_25329375_ChIP-Seq_VCAP_Human1.02232233
91FOXA1_27270436_Chip-Seq_PROSTATE_Human1.02232233
92CBX2_27304074_Chip-Seq_ESCs_Mouse1.02132407
93MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.02022189
94TBL1_22424771_ChIP-Seq_293T_Human1.01688918
95TP63_23658742_ChIP-Seq_EP156T_Human1.00754963
96CTNNB1_20460455_ChIP-Seq_HCT116_Human1.00284432
97FLI1_21867929_ChIP-Seq_TH2_Mouse0.98945277
98STAT3_18555785_Chip-Seq_ESCs_Mouse0.98021927
99* SMAD4_21741376_ChIP-Seq_HESCs_Human0.97595276
100AR_20517297_ChIP-Seq_VCAP_Human0.96732982

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002653_abnormal_ependyma_morphology5.54907911
2MP0008875_abnormal_xenobiotic_pharmacok3.43711852
3MP0001984_abnormal_olfaction3.20967810
4MP0004043_abnormal_pH_regulation2.95498073
5MP0003136_yellow_coat_color2.49724030
6MP0000383_abnormal_hair_follicle2.40736880
7MP0000569_abnormal_digit_pigmentation2.38550580
8MP0005551_abnormal_eye_electrophysiolog2.37240941
9MP0004133_heterotaxia2.36295311
10MP0009046_muscle_twitch2.23688881
11MP0001485_abnormal_pinna_reflex2.21612412
12MP0003195_calcinosis2.05777119
13MP0005623_abnormal_meninges_morphology1.90613311
14MP0002638_abnormal_pupillary_reflex1.79986482
15MP0005253_abnormal_eye_physiology1.79077745
16MP0001486_abnormal_startle_reflex1.72833043
17MP0002876_abnormal_thyroid_physiology1.72353069
18MP0002282_abnormal_trachea_morphology1.71954341
19MP0008877_abnormal_DNA_methylation1.69553606
20MP0009745_abnormal_behavioral_response1.69423074
21MP0002102_abnormal_ear_morphology1.69394130
22MP0010678_abnormal_skin_adnexa1.65121953
23MP0002160_abnormal_reproductive_system1.63406847
24MP0002277_abnormal_respiratory_mucosa1.60054195
25MP0001501_abnormal_sleep_pattern1.51831020
26MP0002132_abnormal_respiratory_system1.50377665
27MP0002928_abnormal_bile_duct1.49150045
28MP0001968_abnormal_touch/_nociception1.48631259
29MP0009780_abnormal_chondrocyte_physiolo1.48585196
30MP0005646_abnormal_pituitary_gland1.48405164
31MP0002734_abnormal_mechanical_nocicepti1.47759091
32MP0002272_abnormal_nervous_system1.47056851
33MP0004885_abnormal_endolymph1.46870638
34MP0002735_abnormal_chemical_nociception1.45065375
35MP0008789_abnormal_olfactory_epithelium1.45055129
36MP0005645_abnormal_hypothalamus_physiol1.45044298
37MP0000631_abnormal_neuroendocrine_gland1.43956426
38MP0000427_abnormal_hair_cycle1.41268428
39MP0003880_abnormal_central_pattern1.40210797
40MP0002572_abnormal_emotion/affect_behav1.39113105
41MP0003878_abnormal_ear_physiology1.38542834
42MP0005377_hearing/vestibular/ear_phenot1.38542834
43MP0006276_abnormal_autonomic_nervous1.30987043
44MP0000566_synostosis1.30602424
45MP0008872_abnormal_physiological_respon1.28228470
46MP0001970_abnormal_pain_threshold1.28187843
47MP0004142_abnormal_muscle_tone1.28150026
48MP0002736_abnormal_nociception_after1.26257457
49MP0000026_abnormal_inner_ear1.26032859
50MP0002557_abnormal_social/conspecific_i1.20755488
51MP0001502_abnormal_circadian_rhythm1.18758334
52MP0004742_abnormal_vestibular_system1.16259598
53MP0010386_abnormal_urinary_bladder1.15859524
54MP0002168_other_aberrant_phenotype1.13501110
55MP0002064_seizures1.13143929
56MP0003698_abnormal_male_reproductive1.10313142
57MP0004019_abnormal_vitamin_homeostasis1.10150132
58MP0005195_abnormal_posterior_eye1.10021551
59MP0005389_reproductive_system_phenotype1.08252396
60MP0002229_neurodegeneration1.07384164
61MP0004147_increased_porphyrin_level1.07268331
62MP0002909_abnormal_adrenal_gland1.06946349
63MP0000778_abnormal_nervous_system1.06300704
64MP0002067_abnormal_sensory_capabilities1.05304992
65MP0001963_abnormal_hearing_physiology1.04612667
66MP0003283_abnormal_digestive_organ1.01515920
67MP0003635_abnormal_synaptic_transmissio1.00595146
68MP0002063_abnormal_learning/memory/cond1.00524732
69MP0000955_abnormal_spinal_cord0.99935338
70MP0005174_abnormal_tail_pigmentation0.97811386
71MP0006072_abnormal_retinal_apoptosis0.95622973
72MP0005167_abnormal_blood-brain_barrier0.94358771
73MP0005499_abnormal_olfactory_system0.94211506
74MP0005394_taste/olfaction_phenotype0.94211506
75MP0003937_abnormal_limbs/digits/tail_de0.94167625
76MP0001929_abnormal_gametogenesis0.93866611
77MP0003890_abnormal_embryonic-extraembry0.92220328
78MP0001293_anophthalmia0.90838355
79MP0002938_white_spotting0.89410743
80MP0001986_abnormal_taste_sensitivity0.89119463
81MP0004924_abnormal_behavior0.88787429
82MP0005386_behavior/neurological_phenoty0.88787429
83MP0001529_abnormal_vocalization0.88207641
84MP0001765_abnormal_ion_homeostasis0.87514040
85MP0002752_abnormal_somatic_nervous0.87121752
86MP0005248_abnormal_Harderian_gland0.87009169
87MP0002733_abnormal_thermal_nociception0.86888702
88MP0005391_vision/eye_phenotype0.85663430
89MP0003879_abnormal_hair_cell0.84995852
90MP0003633_abnormal_nervous_system0.84901826
91MP0003646_muscle_fatigue0.84123676
92MP0002234_abnormal_pharynx_morphology0.84075366
93MP0004859_abnormal_synaptic_plasticity0.83208832
94MP0001324_abnormal_eye_pigmentation0.82757021
95MP0005085_abnormal_gallbladder_physiolo0.81999006
96MP0003787_abnormal_imprinting0.81050663
97MP0002882_abnormal_neuron_morphology0.79360717
98MP0002837_dystrophic_cardiac_calcinosis0.78786341
99MP0005423_abnormal_somatic_nervous0.78371404
100MP0002233_abnormal_nose_morphology0.77171166

Predicted human phenotypes

RankGene SetZ-score
1Abnormal ciliary motility (HP:0012262)9.42002912
2Absent/shortened dynein arms (HP:0200106)9.20130198
3Dynein arm defect of respiratory motile cilia (HP:0012255)9.20130198
4Abnormal respiratory motile cilium physiology (HP:0012261)9.13710093
5Abnormal respiratory epithelium morphology (HP:0012253)8.74617694
6Abnormal respiratory motile cilium morphology (HP:0005938)8.74617694
7Rhinitis (HP:0012384)7.95061559
8Chronic bronchitis (HP:0004469)5.83335365
9Bronchiectasis (HP:0002110)5.68264104
10Pancreatic fibrosis (HP:0100732)4.86940801
11Nasal polyposis (HP:0100582)4.74162957
12True hermaphroditism (HP:0010459)4.72330281
13Pancreatic cysts (HP:0001737)4.51298035
14Abnormality of midbrain morphology (HP:0002418)4.32378098
15Molar tooth sign on MRI (HP:0002419)4.32378098
16Chronic hepatic failure (HP:0100626)4.12863235
17Nephronophthisis (HP:0000090)4.08096568
18Occipital encephalocele (HP:0002085)3.85294933
19Abnormality of the nasal mucosa (HP:0000433)3.81265241
20Recurrent sinusitis (HP:0011108)3.63472086
21Cystic liver disease (HP:0006706)3.63009144
22Abnormality of the renal medulla (HP:0100957)3.41821914
23Bronchitis (HP:0012387)3.39361080
24Medial flaring of the eyebrow (HP:0010747)3.23234983
25Tubular atrophy (HP:0000092)3.13716632
26Chronic sinusitis (HP:0011109)3.11048013
27Infertility (HP:0000789)2.94961484
28Postaxial foot polydactyly (HP:0001830)2.92986814
29Gait imbalance (HP:0002141)2.86066756
30Congenital hepatic fibrosis (HP:0002612)2.81666171
31Congenital primary aphakia (HP:0007707)2.80204709
32Aplasia/Hypoplasia of the tongue (HP:0010295)2.79783196
33Abnormality of the renal cortex (HP:0011035)2.64840690
34Nephrogenic diabetes insipidus (HP:0009806)2.62402533
35Anencephaly (HP:0002323)2.56639651
36Recurrent otitis media (HP:0000403)2.56248831
37Tubulointerstitial nephritis (HP:0001970)2.53234911
38Polydipsia (HP:0001959)2.51098022
39Abnormal drinking behavior (HP:0030082)2.51098022
40Sclerocornea (HP:0000647)2.41570404
41Furrowed tongue (HP:0000221)2.28231731
42Male pseudohermaphroditism (HP:0000037)2.27288166
43Genital tract atresia (HP:0001827)2.27044164
44Chronic otitis media (HP:0000389)2.24161104
45Bile duct proliferation (HP:0001408)2.23645510
46Abnormal biliary tract physiology (HP:0012439)2.23645510
47Vaginal atresia (HP:0000148)2.19540996
48Postaxial hand polydactyly (HP:0001162)2.19365520
49Poor coordination (HP:0002370)2.12375128
50Absent rod-and cone-mediated responses on ERG (HP:0007688)2.10785462
51Decreased circulating renin level (HP:0003351)2.07105320
52Male infertility (HP:0003251)2.05305978
53Oculomotor apraxia (HP:0000657)2.01643859
54Respiratory insufficiency due to defective ciliary clearance (HP:0200073)10.3578677
55Preaxial hand polydactyly (HP:0001177)1.96764481
56Abnormal rod and cone electroretinograms (HP:0008323)1.93823473
57Hyperactive renin-angiotensin system (HP:0000841)1.91026050
58Hyperventilation (HP:0002883)1.85376779
59Tubulointerstitial abnormality (HP:0001969)1.85229877
60Polyuria (HP:0000103)1.82134601
61Decreased central vision (HP:0007663)1.73600477
62Congenital stationary night blindness (HP:0007642)1.71961642
63Recurrent bronchitis (HP:0002837)1.71628759
64Median cleft lip (HP:0000161)1.71421523
65Type II lissencephaly (HP:0007260)1.71116398
66Stage 5 chronic kidney disease (HP:0003774)1.71089450
67Progressive cerebellar ataxia (HP:0002073)1.62466585
68Bony spicule pigmentary retinopathy (HP:0007737)1.62090945
69Aplasia/Hypoplasia of the spleen (HP:0010451)1.61530520
70Gaze-evoked nystagmus (HP:0000640)1.61291864
71Bell-shaped thorax (HP:0001591)1.60968208
72Nephropathy (HP:0000112)1.60491836
73Aplasia/Hypoplasia of the tibia (HP:0005772)1.59009952
74Narrow forehead (HP:0000341)1.56686742
75Asplenia (HP:0001746)1.56588991
76Absent speech (HP:0001344)1.53921276
77Supernumerary spleens (HP:0009799)1.51974518
78Prominent nasal bridge (HP:0000426)1.49661989
79Abnormality of renal excretion (HP:0011036)1.48247030
80Abnormality of renin-angiotensin system (HP:0000847)1.47917579
81Genetic anticipation (HP:0003743)1.47474020
82Retinitis pigmentosa (HP:0000510)1.47209582
83Abnormal urine output (HP:0012590)1.45335477
84Tubulointerstitial fibrosis (HP:0005576)1.44411614
85Atelectasis (HP:0100750)1.41998133
86Hyperaldosteronism (HP:0000859)1.40699163
87Aplasia/Hypoplasia of the lens (HP:0008063)1.40185686
88Hypokalemic alkalosis (HP:0001949)1.39788082
89Highly arched eyebrow (HP:0002553)1.38891819
90Aganglionic megacolon (HP:0002251)1.38486286
91Anophthalmia (HP:0000528)1.37039698
92Renal salt wasting (HP:0000127)1.35455396
93Multicystic kidney dysplasia (HP:0000003)1.35011431
94Broad foot (HP:0001769)1.33743271
95Specific learning disability (HP:0001328)1.33064330
96Broad-based gait (HP:0002136)1.31337167
97Abolished electroretinogram (ERG) (HP:0000550)1.31034040
98Hyperkalemia (HP:0002153)1.30975769
99Febrile seizures (HP:0002373)1.30847328
100Abnormality of macular pigmentation (HP:0008002)1.27823644

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK156.22217462
2FRK5.78417386
3ACVR1B2.69555286
4BMPR1B2.66585337
5PNCK2.65042773
6MST42.54115154
7ADRBK22.24243996
8WNK32.11325331
9CASK2.02326968
10PINK11.95002847
11MAP4K21.91825105
12GRK11.91406181
13PTK2B1.84610718
14MAPK131.82850346
15TLK11.80281838
16MAP3K41.75503432
17STK391.73189146
18BCR1.70752220
19INSRR1.69115196
20WNK41.52409636
21OXSR11.52009570
22TNIK1.45968901
23CAMKK21.41809760
24TAOK31.41272009
25NTRK31.35052098
26MAPKAPK31.30809926
27STK38L1.28421238
28EPHA41.15873194
29NUAK11.09144655
30MAP2K71.06736435
31ADRBK10.98419526
32EPHA30.94621184
33NTRK20.92017304
34DAPK20.91495489
35ERBB30.91143094
36MARK10.88422149
37IRAK10.88074833
38PRKCE0.86605060
39ZAK0.84632368
40ERBB20.84277373
41MAP3K70.83909472
42NLK0.82525072
43TGFBR10.81556935
44FER0.80905494
45PAK30.80490270
46EPHA20.79844339
47NME10.77438219
48BRSK20.75610048
49PIK3CA0.75320549
50FGFR20.73670527
51MKNK20.72148225
52TSSK60.68755712
53STK30.67673616
54CAMK2A0.67554089
55CAMK1G0.65942175
56PRKCG0.65276859
57STK110.64391313
58LATS10.63660964
59AKT30.63068061
60TIE10.62538177
61SGK20.61666107
62MET0.60306309
63PLK20.60201906
64MUSK0.58912285
65TRIM280.58841216
66STK240.58000591
67TRPM70.57267134
68MAPKAPK50.56270395
69CSNK1G20.53759806
70CAMKK10.52542464
71PRKCI0.52501731
72MAP3K20.52221718
73PRKCQ0.50155533
74CAMK10.49090609
75NEK60.48094519
76PRKAA20.47683285
77CSNK1G10.47392098
78CAMK40.46501255
79PRKACA0.45184772
80PKN10.45120908
81PHKG20.45025639
82PHKG10.45025639
83DYRK1A0.44526528
84DYRK20.43519238
85PRKCZ0.42894454
86CHUK0.42867838
87SGK2230.40165969
88SGK4940.40165969
89VRK10.39298749
90MAP2K40.39249036
91TEC0.37745168
92STK380.36932273
93PRKCA0.35582224
94SGK10.35355983
95WEE10.34352978
96PRKAA10.31738272
97PRKG10.31732471
98ROCK10.30288711
99ABL10.29563370
100MAP2K10.29465219

Predicted pathways (KEGG)

RankGene SetZ-score
1Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.86496308
2Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.81382981
3Linoleic acid metabolism_Homo sapiens_hsa005912.75164377
4Chemical carcinogenesis_Homo sapiens_hsa052042.64985343
5Nicotine addiction_Homo sapiens_hsa050332.56879786
6Histidine metabolism_Homo sapiens_hsa003402.55115041
7ABC transporters_Homo sapiens_hsa020102.34139204
8Phototransduction_Homo sapiens_hsa047442.33440240
9Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.16328695
10Nitrogen metabolism_Homo sapiens_hsa009102.04180941
11beta-Alanine metabolism_Homo sapiens_hsa004102.00676280
12alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.95466512
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.92439813
14Butanoate metabolism_Homo sapiens_hsa006501.89248798
15Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.88057170
16Caffeine metabolism_Homo sapiens_hsa002321.82535525
17Taste transduction_Homo sapiens_hsa047421.69711958
18Huntingtons disease_Homo sapiens_hsa050161.69103243
19Retinol metabolism_Homo sapiens_hsa008301.66311971
20Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.61685183
21Olfactory transduction_Homo sapiens_hsa047401.59802521
22Maturity onset diabetes of the young_Homo sapiens_hsa049501.56647894
23Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.55022903
24Salivary secretion_Homo sapiens_hsa049701.52001256
25Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.50212186
26Steroid hormone biosynthesis_Homo sapiens_hsa001401.47122669
27Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.46707223
28Primary bile acid biosynthesis_Homo sapiens_hsa001201.43822934
29Tryptophan metabolism_Homo sapiens_hsa003801.42062582
30Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.41807298
31Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.40815183
32Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.34395548
33Tyrosine metabolism_Homo sapiens_hsa003501.33388883
34Circadian rhythm_Homo sapiens_hsa047101.32353903
35Ether lipid metabolism_Homo sapiens_hsa005651.28830462
36Glutamatergic synapse_Homo sapiens_hsa047241.25448120
37Phenylalanine metabolism_Homo sapiens_hsa003601.25286714
38Peroxisome_Homo sapiens_hsa041461.24034705
39Insulin secretion_Homo sapiens_hsa049111.21326303
40Circadian entrainment_Homo sapiens_hsa047131.19571504
41Morphine addiction_Homo sapiens_hsa050321.19437877
42Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.14472489
43Arachidonic acid metabolism_Homo sapiens_hsa005901.13474759
44Serotonergic synapse_Homo sapiens_hsa047261.12969371
45Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.12324331
46Propanoate metabolism_Homo sapiens_hsa006401.10421857
47GABAergic synapse_Homo sapiens_hsa047271.08618864
48Selenocompound metabolism_Homo sapiens_hsa004501.04282791
49Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.99697168
50Sphingolipid metabolism_Homo sapiens_hsa006000.97337680
51Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.94157440
52Calcium signaling pathway_Homo sapiens_hsa040200.92899491
53Dorso-ventral axis formation_Homo sapiens_hsa043200.92458426
54Carbohydrate digestion and absorption_Homo sapiens_hsa049730.88530771
55Cocaine addiction_Homo sapiens_hsa050300.88524983
56Glutathione metabolism_Homo sapiens_hsa004800.88072713
57Ovarian steroidogenesis_Homo sapiens_hsa049130.84365198
58Glycerolipid metabolism_Homo sapiens_hsa005610.80546555
59Amphetamine addiction_Homo sapiens_hsa050310.78895223
60Hedgehog signaling pathway_Homo sapiens_hsa043400.78408267
61Regulation of autophagy_Homo sapiens_hsa041400.76579449
62Gastric acid secretion_Homo sapiens_hsa049710.74384584
63Pancreatic secretion_Homo sapiens_hsa049720.74370721
64Pentose and glucuronate interconversions_Homo sapiens_hsa000400.70493243
65Basal cell carcinoma_Homo sapiens_hsa052170.69565459
66cAMP signaling pathway_Homo sapiens_hsa040240.68971932
67Fatty acid degradation_Homo sapiens_hsa000710.68497175
68Fanconi anemia pathway_Homo sapiens_hsa034600.66017841
69Vascular smooth muscle contraction_Homo sapiens_hsa042700.64009585
70Tight junction_Homo sapiens_hsa045300.62952559
71Dopaminergic synapse_Homo sapiens_hsa047280.61826917
72Collecting duct acid secretion_Homo sapiens_hsa049660.60562087
73Glycerophospholipid metabolism_Homo sapiens_hsa005640.58667256
74Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.57071267
75Bile secretion_Homo sapiens_hsa049760.56722034
76Basal transcription factors_Homo sapiens_hsa030220.55761627
77Oxytocin signaling pathway_Homo sapiens_hsa049210.53060788
78Long-term depression_Homo sapiens_hsa047300.52592882
79Mineral absorption_Homo sapiens_hsa049780.52564730
80Fatty acid biosynthesis_Homo sapiens_hsa000610.51404159
81Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.48248336
82Aldosterone synthesis and secretion_Homo sapiens_hsa049250.48147286
83Hippo signaling pathway_Homo sapiens_hsa043900.46409208
84Renin secretion_Homo sapiens_hsa049240.46278387
85Cardiac muscle contraction_Homo sapiens_hsa042600.45833356
86Cholinergic synapse_Homo sapiens_hsa047250.40382849
87Axon guidance_Homo sapiens_hsa043600.40133692
88Metabolic pathways_Homo sapiens_hsa011000.37669345
89Arginine and proline metabolism_Homo sapiens_hsa003300.36806367
90Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.36234136
91Protein export_Homo sapiens_hsa030600.35024085
92Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.34920080
93Choline metabolism in cancer_Homo sapiens_hsa052310.34327645
94Thyroid hormone synthesis_Homo sapiens_hsa049180.34094921
95Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.32366554
96Starch and sucrose metabolism_Homo sapiens_hsa005000.32347840
97TGF-beta signaling pathway_Homo sapiens_hsa043500.31441706
98Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.31085609
99PPAR signaling pathway_Homo sapiens_hsa033200.29723300
100Oxidative phosphorylation_Homo sapiens_hsa001900.28898325

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