DNAH9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the heavy chain subunit of axonemal dynein, a large multi-subunit molecular motor. Axonemal dynein attaches to microtubules and hydrolyzes ATP to mediate the movement of cilia and flagella. The gene expresses at least two transcript variants; additional variants have been described, but their full length nature has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of cilium movement (GO:0003352)8.61282116
2cilium movement (GO:0003341)7.51933838
3primary alcohol catabolic process (GO:0034310)6.45618113
4axoneme assembly (GO:0035082)6.31044862
5vitamin transmembrane transport (GO:0035461)6.19193803
6axonemal dynein complex assembly (GO:0070286)5.83312690
7cilium or flagellum-dependent cell motility (GO:0001539)5.64815203
8ethanol metabolic process (GO:0006067)5.43904744
9epithelial cilium movement (GO:0003351)5.28199279
10regulation of microtubule-based movement (GO:0060632)5.24216741
11diterpenoid biosynthetic process (GO:0016102)5.21377578
12response to xenobiotic stimulus (GO:0009410)5.09675794
13epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.05414685
14centriole assembly (GO:0098534)4.83695410
15one-carbon compound transport (GO:0019755)4.71939522
16ventricular system development (GO:0021591)4.71163727
17pyrimidine-containing compound transmembrane transport (GO:0072531)4.68155144
18positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.44042212
19intraciliary transport (GO:0042073)4.43266622
20lung epithelium development (GO:0060428)4.43149406
21negative regulation of T cell differentiation in thymus (GO:0033085)4.40470673
22sperm capacitation (GO:0048240)4.38592477
23tolerance induction (GO:0002507)4.34987614
24glomerular epithelial cell development (GO:0072310)4.27494020
25regulation of interleukin-5 production (GO:0032674)4.27210202
26left/right axis specification (GO:0070986)4.19046779
27negative regulation of B cell mediated immunity (GO:0002713)4.14559889
28negative regulation of immunoglobulin mediated immune response (GO:0002890)4.14559889
29ethanol oxidation (GO:0006069)4.08869871
30lateral ventricle development (GO:0021670)4.07696425
31regulation of short-term neuronal synaptic plasticity (GO:0048172)3.98487449
32negative regulation of humoral immune response (GO:0002921)3.93091648
33establishment of apical/basal cell polarity (GO:0035089)3.85927369
34regulation of interleukin-13 production (GO:0032656)3.85903268
35synaptic transmission, glutamatergic (GO:0035249)3.81702297
36retinoic acid metabolic process (GO:0042573)3.78797036
37microtubule depolymerization (GO:0007019)3.77938552
38ionotropic glutamate receptor signaling pathway (GO:0035235)3.77120266
39regulation of germinal center formation (GO:0002634)3.73464561
40terpenoid biosynthetic process (GO:0016114)3.67726883
41detection of calcium ion (GO:0005513)3.67693024
42cilium organization (GO:0044782)3.65052616
43retinal rod cell development (GO:0046548)3.64839441
44cytoplasmic microtubule organization (GO:0031122)3.61583981
45microtubule polymerization or depolymerization (GO:0031109)3.60849443
46vocalization behavior (GO:0071625)3.60073107
47negative regulation of inclusion body assembly (GO:0090084)3.57392328
48sperm motility (GO:0030317)3.56075508
49negative regulation of hormone metabolic process (GO:0032351)3.55659532
50negative regulation of hormone biosynthetic process (GO:0032353)3.55659532
51negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.54839373
52cilium assembly (GO:0042384)3.52509373
53retinal cone cell development (GO:0046549)3.51663739
54establishment or maintenance of monopolar cell polarity (GO:0061339)3.49455228
55establishment of monopolar cell polarity (GO:0061162)3.49455228
56microtubule bundle formation (GO:0001578)3.48424446
57glutamate receptor signaling pathway (GO:0007215)3.48008157
58regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.44255190
59regulation of glutamate receptor signaling pathway (GO:1900449)3.43744371
60determination of left/right symmetry (GO:0007368)3.38243043
61exogenous drug catabolic process (GO:0042738)3.38171727
62regulation of calcium ion-dependent exocytosis (GO:0017158)3.36701678
63positive regulation of tolerance induction (GO:0002645)3.36100400
64regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.35399818
65axonal fasciculation (GO:0007413)3.30615809
66neuron recognition (GO:0008038)3.27798087
67determination of bilateral symmetry (GO:0009855)3.24266668
68synaptic vesicle maturation (GO:0016188)3.22929223
69motile cilium assembly (GO:0044458)3.21772904
70neuron cell-cell adhesion (GO:0007158)3.21413203
71neuron-neuron synaptic transmission (GO:0007270)3.18362917
72establishment of planar polarity (GO:0001736)3.16982651
73establishment of tissue polarity (GO:0007164)3.16982651
74specification of symmetry (GO:0009799)3.16766421
75membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.09940331
76membrane repolarization during action potential (GO:0086011)3.09039981
77centriole replication (GO:0007099)3.08581431
78locomotory exploration behavior (GO:0035641)3.06426629
79positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.06389741
80O-glycan processing (GO:0016266)3.05331731
81protein localization to cilium (GO:0061512)3.03810703
82photoreceptor cell maintenance (GO:0045494)3.03116508
83innervation (GO:0060384)3.03076257
84cilium morphogenesis (GO:0060271)3.02769718
85calcium ion import (GO:0070509)3.01983390
86nucleoside diphosphate phosphorylation (GO:0006165)3.00489912
87positive regulation of smoothened signaling pathway (GO:0045880)2.98374824
88cochlea development (GO:0090102)2.97616459
89regulation of synaptic vesicle exocytosis (GO:2000300)2.97047978
90endocrine pancreas development (GO:0031018)2.96918589
91chemosensory behavior (GO:0007635)2.96280870
92glutamate secretion (GO:0014047)2.96033739
93glutathione derivative biosynthetic process (GO:1901687)2.95753122
94glutathione derivative metabolic process (GO:1901685)2.95753122
95regulation of neuronal synaptic plasticity (GO:0048168)2.95383103
96primary alcohol metabolic process (GO:0034308)2.95002336
97long-term memory (GO:0007616)2.94924981
98retinol metabolic process (GO:0042572)2.94552797
99regulation of synaptic vesicle transport (GO:1902803)2.89658131
100startle response (GO:0001964)2.89321704
101positive regulation of vesicle fusion (GO:0031340)2.88464851
102membrane depolarization during action potential (GO:0086010)2.85760160
103* microtubule-based process (GO:0007017)2.83099215
104nonmotile primary cilium assembly (GO:0035058)2.82908529
105aldehyde catabolic process (GO:0046185)2.82646361
106lateral sprouting from an epithelium (GO:0060601)2.81336043
107transmission of nerve impulse (GO:0019226)2.81045442
108drug catabolic process (GO:0042737)2.78968922
109cellular component assembly involved in morphogenesis (GO:0010927)2.75665868
110G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.75592415
111synaptic vesicle exocytosis (GO:0016079)2.75021103
112protein localization to synapse (GO:0035418)2.73186907
113type B pancreatic cell development (GO:0003323)2.72533015
114regulation of vesicle fusion (GO:0031338)2.72512756
115dendritic spine morphogenesis (GO:0060997)2.72121683
116organelle assembly (GO:0070925)2.71585995
117hydrogen peroxide biosynthetic process (GO:0050665)2.70083816
118* microtubule-based movement (GO:0007018)2.69261140
119negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.66168877
120insulin secretion (GO:0030073)2.66055439
121central nervous system projection neuron axonogenesis (GO:0021952)2.65958515
122regulation of neuron projection regeneration (GO:0070570)2.64639553
123regulation of axon regeneration (GO:0048679)2.64639553
124regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.63931140
125carnitine metabolic process (GO:0009437)2.61522553
126cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.60266490
127inner ear receptor cell development (GO:0060119)2.60194711
128regulation of insulin secretion (GO:0050796)2.59678431
129eye photoreceptor cell differentiation (GO:0001754)2.59660872
130photoreceptor cell differentiation (GO:0046530)2.59660872
131regulation of type B pancreatic cell apoptotic process (GO:2000674)2.58496282
132GTP biosynthetic process (GO:0006183)2.58315197
133membrane repolarization (GO:0086009)2.57704712
134regulation of long-term neuronal synaptic plasticity (GO:0048169)2.56790449
135sensory perception of smell (GO:0007608)2.55842757
136phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.55566146
137exploration behavior (GO:0035640)2.54733848
138nerve growth factor signaling pathway (GO:0038180)2.54012233
139phosphorelay signal transduction system (GO:0000160)2.53699544
140cerebellar Purkinje cell differentiation (GO:0021702)2.51519390
141gamma-aminobutyric acid signaling pathway (GO:0007214)2.50466829
142excretion (GO:0007588)2.50302431
143negative regulation of adenylate cyclase activity (GO:0007194)2.49649053
144regulation of microtubule depolymerization (GO:0031114)2.49355330
145positive regulation of synapse maturation (GO:0090129)2.48921353
146positive regulation of meiosis (GO:0045836)2.48345435
147regulation of exocytosis (GO:0017157)2.48165418
148regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.47999206
149apical protein localization (GO:0045176)2.47918881
150dendritic spine organization (GO:0097061)2.46723225
151protein polyglutamylation (GO:0018095)2.46416506
152glandular epithelial cell development (GO:0002068)2.46263716
153left/right pattern formation (GO:0060972)2.45622198
154membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.45611720
155glandular epithelial cell differentiation (GO:0002067)2.44581312
156synaptic vesicle docking involved in exocytosis (GO:0016081)2.43995856
157cell communication by electrical coupling (GO:0010644)2.42683528
158gamma-aminobutyric acid transport (GO:0015812)2.41969198
159cell projection assembly (GO:0030031)2.41838010
160multicellular organismal water homeostasis (GO:0050891)2.41449328
161sodium ion homeostasis (GO:0055078)2.41175406
162reactive oxygen species biosynthetic process (GO:1903409)2.40679302
163neuronal action potential propagation (GO:0019227)2.40377665
164positive regulation of CREB transcription factor activity (GO:0032793)2.39865524
165smoothened signaling pathway (GO:0007224)2.39478485
166phosphatidylcholine biosynthetic process (GO:0006656)2.39215044
167microtubule severing (GO:0051013)2.39147459
168heart looping (GO:0001947)2.38147066
169regulation of tolerance induction (GO:0002643)2.35847144
170protein O-linked glycosylation (GO:0006493)2.32240549
171regulation of collateral sprouting (GO:0048670)2.27135769
172regulation of smoothened signaling pathway (GO:0008589)2.26714472
173regulation of cilium assembly (GO:1902017)2.26346536
174calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.24551408
175intra-S DNA damage checkpoint (GO:0031573)2.23722961
176progesterone metabolic process (GO:0042448)2.22815321

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.52430611
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.63989415
3GBX2_23144817_ChIP-Seq_PC3_Human3.35352012
4FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.95136970
5* DROSHA_22980978_ChIP-Seq_HELA_Human2.48167364
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.45827771
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.35975381
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.21290160
9SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.19990932
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.04735082
11SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.03885696
12SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.01832564
13BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.99885347
14REST_21632747_ChIP-Seq_MESCs_Mouse1.97920616
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.96802233
16EZH2_18974828_ChIP-Seq_MESCs_Mouse1.94974969
17RNF2_18974828_ChIP-Seq_MESCs_Mouse1.94974969
18MTF2_20144788_ChIP-Seq_MESCs_Mouse1.94956839
19EZH2_27304074_Chip-Seq_ESCs_Mouse1.93101493
20* SMAD4_21799915_ChIP-Seq_A2780_Human1.88954362
21SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.88594183
22EZH2_27294783_Chip-Seq_ESCs_Mouse1.87857221
23IKZF1_21737484_ChIP-ChIP_HCT116_Human1.87566570
24EED_16625203_ChIP-ChIP_MESCs_Mouse1.85458296
25TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.84993287
26* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.80983024
27CTBP1_25329375_ChIP-Seq_LNCAP_Human1.78116265
28SUZ12_27294783_Chip-Seq_ESCs_Mouse1.76814756
29PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.75820589
30RNF2_27304074_Chip-Seq_ESCs_Mouse1.74847422
31ESR1_20079471_ChIP-ChIP_T-47D_Human1.72526617
32PIAS1_25552417_ChIP-Seq_VCAP_Human1.71702158
33SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.70734736
34FOXM1_26456572_ChIP-Seq_MCF-7_Human1.70450956
35CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.69208556
36ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.67795603
37STAT3_23295773_ChIP-Seq_U87_Human1.64637488
38VDR_22108803_ChIP-Seq_LS180_Human1.63786181
39* P300_19829295_ChIP-Seq_ESCs_Human1.61480815
40FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.59707220
41GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.58977428
42BMI1_23680149_ChIP-Seq_NPCS_Mouse1.58465660
43TP63_23658742_ChIP-Seq_EP156T_Human1.56695974
44FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.54545975
45IGF1R_20145208_ChIP-Seq_DFB_Human1.54489676
46ZFP57_27257070_Chip-Seq_ESCs_Mouse1.53978094
47ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.50538021
48ZNF217_24962896_ChIP-Seq_MCF-7_Human1.47250505
49REST_18959480_ChIP-ChIP_MESCs_Mouse1.47197980
50AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.46880710
51TOP2B_26459242_ChIP-Seq_MCF-7_Human1.45980021
52STAT1_20625510_ChIP-Seq_HELA_Human1.45002773
53ZNF274_21170338_ChIP-Seq_K562_Hela1.43903421
54RARB_27405468_Chip-Seq_BRAIN_Mouse1.43887454
55AR_21572438_ChIP-Seq_LNCaP_Human1.43278860
56CBX2_27304074_Chip-Seq_ESCs_Mouse1.41898004
57SMRT_27268052_Chip-Seq_Bcells_Human1.41672752
58NR3C1_21868756_ChIP-Seq_MCF10A_Human1.38847941
59* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.38649824
60ETV1_20927104_ChIP-Seq_GIST48_Human1.37110707
61CTNNB1_20460455_ChIP-Seq_HCT116_Human1.35299756
62NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.33295387
63PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.32294576
64AR_25329375_ChIP-Seq_VCAP_Human1.31880176
65ARNT_22903824_ChIP-Seq_MCF-7_Human1.30361624
66MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.29676415
67AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.29274991
68TP53_16413492_ChIP-PET_HCT116_Human1.29082978
69* SMAD3_21741376_ChIP-Seq_EPCs_Human1.28368850
70TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.27990425
71PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.27685185
72AHR_22903824_ChIP-Seq_MCF-7_Human1.27378805
73ESR1_21235772_ChIP-Seq_MCF-7_Human1.27273811
74PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.27195167
75TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.26996563
76* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.26680010
77* TCF4_23295773_ChIP-Seq_U87_Human1.25299070
78TRIM28_21343339_ChIP-Seq_HEK293_Human1.24925521
79PHF8_20622853_ChIP-Seq_HELA_Human1.24625901
80NR3C1_23031785_ChIP-Seq_PC12_Mouse1.23393182
81FOXA1_25552417_ChIP-Seq_VCAP_Human1.22405621
82NANOG_18555785_Chip-Seq_ESCs_Mouse1.22000353
83EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.21170156
84* SOX2_21211035_ChIP-Seq_LN229_Gbm1.20533664
85TDRD3_21172665_ChIP-Seq_MCF-7_Human1.19278719
86GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.19189689
87RUNX1_27514584_Chip-Seq_MCF-7_Human1.19141118
88RNF2_27304074_Chip-Seq_NSC_Mouse1.18551027
89CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.18452171
90POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.17992859
91TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17992859
92CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.17832717
93YAP1_20516196_ChIP-Seq_MESCs_Mouse1.17827117
94SMC4_20622854_ChIP-Seq_HELA_Human1.17616238
95HNFA_21074721_ChIP-Seq_CACO-2_Human1.17157151
96SMAD_19615063_ChIP-ChIP_OVARY_Human1.16995904
97RUNX2_22187159_ChIP-Seq_PCA_Human1.16986000
98BCAT_22108803_ChIP-Seq_LS180_Human1.16825186
99TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.16820837
100IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.16057016
101CBP_20019798_ChIP-Seq_JUKART_Human1.16057016
102CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.15856366
103RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.14409036
104* AR_19668381_ChIP-Seq_PC3_Human1.13230530
105RBPJ_21746931_ChIP-Seq_IB4_Human1.12679784
106OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12450408
107RAD21_21589869_ChIP-Seq_MESCs_Mouse1.12107170
108ER_23166858_ChIP-Seq_MCF-7_Human1.11241476
109CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10932572
110LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10904546
111WT1_25993318_ChIP-Seq_PODOCYTE_Human1.10110234
112TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.09671012
113EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.09554475
114* TP63_22573176_ChIP-Seq_HFKS_Human1.09527665
115* SMAD4_21741376_ChIP-Seq_EPCs_Human1.09512018
116* TCF4_22108803_ChIP-Seq_LS180_Human1.09449956
117CDX2_19796622_ChIP-Seq_MESCs_Mouse1.09162602
118* KLF5_25053715_ChIP-Seq_YYC3_Human1.08798830
119SMAD4_21741376_ChIP-Seq_HESCs_Human1.07534837
120SOX2_27498859_Chip-Seq_STOMACH_Mouse1.07429730
121NFYA_21822215_ChIP-Seq_K562_Human1.07072486
122NFYB_21822215_ChIP-Seq_K562_Human1.06979264
123FUS_26573619_Chip-Seq_HEK293_Human1.06918367
124ESR2_21235772_ChIP-Seq_MCF-7_Human1.06708239
125SMAD3_21741376_ChIP-Seq_HESCs_Human1.06425313
126CBX2_22325352_ChIP-Seq_293T-Rex_Human1.05720085
127FOXA1_27270436_Chip-Seq_PROSTATE_Human1.05135561
128FOXA1_25329375_ChIP-Seq_VCAP_Human1.05135561
129TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03653028
130TP53_18474530_ChIP-ChIP_U2OS_Human1.03510446
131SMAD3_21741376_ChIP-Seq_ESCs_Human1.02155711
132RING1B_27294783_Chip-Seq_ESCs_Mouse1.01980774
133PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.01699821
134* PRDM14_20953172_ChIP-Seq_ESCs_Human1.01279390
135SOX9_24532713_ChIP-Seq_HFSC_Mouse1.00339345
136BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.00328024
137CEBPB_22108803_ChIP-Seq_LS180_Human1.00198583
138AR_20517297_ChIP-Seq_VCAP_Human0.99214700
139LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98909789
140GATA6_21074721_ChIP-Seq_CACO-2_Human0.98220524
141UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.97950275
142P53_22387025_ChIP-Seq_ESCs_Mouse0.97879678
143SUZ12_27294783_Chip-Seq_NPCs_Mouse0.97779649
144SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.97715353
145MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.96964853
146E2F1_18555785_Chip-Seq_ESCs_Mouse0.96215833
147GATA4_25053715_ChIP-Seq_YYC3_Human0.95603846
148P63_26484246_Chip-Seq_KERATINOCYTES_Human0.94591145
149* TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.94356954
150ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.94134172
151TBL1_22424771_ChIP-Seq_293T_Human0.93932268
152STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.93774496
153TAF15_26573619_Chip-Seq_HEK293_Human0.93694556
154CMYC_18555785_Chip-Seq_ESCs_Mouse0.93195707
155RBPJ_22232070_ChIP-Seq_NCS_Mouse0.92775251
156TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.92156600
157GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.91489094
158PCGF2_27294783_Chip-Seq_ESCs_Mouse0.91452043

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008875_abnormal_xenobiotic_pharmacok6.72195906
2MP0004859_abnormal_synaptic_plasticity5.00102117
3MP0002132_abnormal_respiratory_system4.89494966
4MP0003880_abnormal_central_pattern4.04834971
5MP0002277_abnormal_respiratory_mucosa3.45052063
6MP0005623_abnormal_meninges_morphology3.42149563
7MP0005646_abnormal_pituitary_gland3.21077076
8MP0003635_abnormal_synaptic_transmissio2.93127967
9MP0004270_analgesia2.80689549
10MP0003283_abnormal_digestive_organ2.73805561
11MP0000383_abnormal_hair_follicle2.53222781
12MP0002876_abnormal_thyroid_physiology2.44079048
13MP0002735_abnormal_chemical_nociception2.37259698
14MP0003878_abnormal_ear_physiology2.34934926
15MP0005377_hearing/vestibular/ear_phenot2.34934926
16MP0001968_abnormal_touch/_nociception2.32531175
17MP0002063_abnormal_learning/memory/cond2.32481980
18MP0002734_abnormal_mechanical_nocicepti2.29232073
19MP0002909_abnormal_adrenal_gland2.29153535
20MP0006292_abnormal_olfactory_placode2.28796319
21MP0009745_abnormal_behavioral_response2.28520953
22MP0000566_synostosis2.26867819
23MP0001501_abnormal_sleep_pattern2.26266912
24MP0005645_abnormal_hypothalamus_physiol2.19699803
25MP0002572_abnormal_emotion/affect_behav2.19044390
26MP0009780_abnormal_chondrocyte_physiolo2.16397795
27MP0003787_abnormal_imprinting2.15985239
28MP0002653_abnormal_ependyma_morphology2.09197587
29MP0002282_abnormal_trachea_morphology2.05715236
30MP0003879_abnormal_hair_cell2.04757572
31MP0010678_abnormal_skin_adnexa2.04569711
32MP0002693_abnormal_pancreas_physiology1.95090043
33MP0001944_abnormal_pancreas_morphology1.93988060
34MP0002272_abnormal_nervous_system1.93107789
35MP0004019_abnormal_vitamin_homeostasis1.92304049
36MP0010386_abnormal_urinary_bladder1.88672749
37MP0002877_abnormal_melanocyte_morpholog1.86184627
38MP0002638_abnormal_pupillary_reflex1.84985920
39MP0001984_abnormal_olfaction1.84484843
40MP0002064_seizures1.84248466
41MP0002168_other_aberrant_phenotype1.84174400
42MP0001440_abnormal_grooming_behavior1.81675234
43MP0008004_abnormal_stomach_pH1.76501024
44MP0005083_abnormal_biliary_tract1.76383589
45MP0002736_abnormal_nociception_after1.74968302
46MP0002160_abnormal_reproductive_system1.68456215
47MP0000678_abnormal_parathyroid_gland1.66371850
48MP0006072_abnormal_retinal_apoptosis1.66220994
49MP0003122_maternal_imprinting1.65979864
50MP0001486_abnormal_startle_reflex1.65465863
51MP0001502_abnormal_circadian_rhythm1.62621054
52MP0000778_abnormal_nervous_system1.59734918
53MP0006276_abnormal_autonomic_nervous1.59249497
54MP0005551_abnormal_eye_electrophysiolog1.57822999
55MP0003656_abnormal_erythrocyte_physiolo1.53429238
56MP0002733_abnormal_thermal_nociception1.52741307
57MP0003136_yellow_coat_color1.49776088
58MP0002184_abnormal_innervation1.47878528
59MP0002234_abnormal_pharynx_morphology1.45924877
60MP0001485_abnormal_pinna_reflex1.45476597
61MP0001970_abnormal_pain_threshold1.45371161
62MP0002557_abnormal_social/conspecific_i1.42602108
63MP0002837_dystrophic_cardiac_calcinosis1.41060219
64MP0002928_abnormal_bile_duct1.39100322
65MP0000631_abnormal_neuroendocrine_gland1.34131340
66MP0004133_heterotaxia1.34093892
67MP0001188_hyperpigmentation1.33419219
68MP0005395_other_phenotype1.33353428
69MP0009046_muscle_twitch1.28354483
70MP0002067_abnormal_sensory_capabilities1.27960220
71MP0004858_abnormal_nervous_system1.23918972
72MP0008877_abnormal_DNA_methylation1.23673638
73MP0002882_abnormal_neuron_morphology1.23565339
74MP0005636_abnormal_mineral_homeostasis1.16006814
75MP0002249_abnormal_larynx_morphology1.15727279
76MP0005379_endocrine/exocrine_gland_phen1.11878607
77MP0003698_abnormal_male_reproductive1.10249633
78MP0000955_abnormal_spinal_cord1.09819282
79MP0004043_abnormal_pH_regulation1.09324293
80MP0001929_abnormal_gametogenesis1.08715716
81MP0001765_abnormal_ion_homeostasis1.08273090
82MP0005253_abnormal_eye_physiology1.07152104
83MP0005423_abnormal_somatic_nervous1.06772830
84MP0002078_abnormal_glucose_homeostasis1.04697223
85MP0003123_paternal_imprinting0.99502620
86MP0003329_amyloid_beta_deposits0.97205818
87MP0000013_abnormal_adipose_tissue0.97179807
88MP0005248_abnormal_Harderian_gland0.95434078
89MP0000613_abnormal_salivary_gland0.94739783
90MP0004811_abnormal_neuron_physiology0.94459374
91MP0004885_abnormal_endolymph0.93978856
92MP0002233_abnormal_nose_morphology0.93444173
93MP0001905_abnormal_dopamine_level0.90745259
94MP0002752_abnormal_somatic_nervous0.89436899
95MP0003953_abnormal_hormone_level0.88248038
96MP0002152_abnormal_brain_morphology0.87924203
97MP0005389_reproductive_system_phenotype0.86963247
98MP0002066_abnormal_motor_capabilities/c0.86872752
99MP0003045_fibrosis0.86681160
100MP0004145_abnormal_muscle_electrophysio0.86625351
101MP0005499_abnormal_olfactory_system0.85970562
102MP0005394_taste/olfaction_phenotype0.85970562
103MP0005310_abnormal_salivary_gland0.84846379
104MP0005165_increased_susceptibility_to0.84422139
105MP0000462_abnormal_digestive_system0.83085929
106MP0000681_abnormal_thyroid_gland0.83013877
107MP0000026_abnormal_inner_ear0.82276986
108MP0008569_lethality_at_weaning0.81859703
109MP0001346_abnormal_lacrimal_gland0.81231680
110MP0005085_abnormal_gallbladder_physiolo0.81133510
111MP0003890_abnormal_embryonic-extraembry0.80755756
112MP0001963_abnormal_hearing_physiology0.80106311
113MP0002229_neurodegeneration0.79682074
114MP0005365_abnormal_bile_salt0.79322262
115MP0009643_abnormal_urine_homeostasis0.78803872
116MP0002069_abnormal_eating/drinking_beha0.78745944
117MP0000465_gastrointestinal_hemorrhage0.77906302
118MP0001177_atelectasis0.76494647
119MP0005187_abnormal_penis_morphology0.75438662
120MP0008872_abnormal_physiological_respon0.75389391
121MP0001293_anophthalmia0.75280686
122MP0005220_abnormal_exocrine_pancreas0.74670281
123MP0005503_abnormal_tendon_morphology0.74526187
124MP0010155_abnormal_intestine_physiology0.72870394
125MP0005195_abnormal_posterior_eye0.72863481
126MP0004924_abnormal_behavior0.71895263
127MP0005386_behavior/neurological_phenoty0.71895263
128MP0002136_abnormal_kidney_physiology0.71327408
129MP0004510_myositis0.71051681
130MP0001324_abnormal_eye_pigmentation0.70684175
131MP0001986_abnormal_taste_sensitivity0.70492971
132MP0005408_hypopigmentation0.68384925
133MP0004782_abnormal_surfactant_physiolog0.68026671
134MP0003718_maternal_effect0.67937354
135MP0002102_abnormal_ear_morphology0.66885171
136MP0001664_abnormal_digestion0.66654212
137MP0003633_abnormal_nervous_system0.66076155
138MP0004085_abnormal_heartbeat0.65765919
139MP0003195_calcinosis0.65603831
140MP0001270_distended_abdomen0.64832767
141MP0008789_abnormal_olfactory_epithelium0.64258087
142MP0005391_vision/eye_phenotype0.62705483
143MP0009765_abnormal_xenobiotic_induced0.60802069
144MP0010030_abnormal_orbit_morphology0.59137534
145MP0005164_abnormal_response_to0.58630617
146MP0002161_abnormal_fertility/fecundity0.53498565
147MP0005410_abnormal_fertilization0.52945795
148MP0002822_catalepsy0.52770614
149MP0008995_early_reproductive_senescence0.52584223
150MP0004883_abnormal_blood_vessel0.51611290
151MP0003950_abnormal_plasma_membrane0.51286920
152MP0003937_abnormal_limbs/digits/tail_de0.50980686
153MP0002405_respiratory_system_inflammati0.49543724
154MP0009703_decreased_birth_body0.47625325
155MP0002116_abnormal_craniofacial_bone0.47317512
156MP0002133_abnormal_respiratory_system0.46811654
157MP0005388_respiratory_system_phenotype0.46811654

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)8.15576727
2Abnormal respiratory motile cilium physiology (HP:0012261)7.82793857
3Abnormal ciliary motility (HP:0012262)7.37656534
4Rhinitis (HP:0012384)6.70933039
5Chronic bronchitis (HP:0004469)5.71247450
6Abnormal respiratory epithelium morphology (HP:0012253)5.47900705
7Abnormal respiratory motile cilium morphology (HP:0005938)5.47900705
8Abnormality of the nasal mucosa (HP:0000433)5.42304686
9Dynein arm defect of respiratory motile cilia (HP:0012255)4.50500072
10Absent/shortened dynein arms (HP:0200106)4.50500072
11Focal motor seizures (HP:0011153)4.48716369
12Recurrent sinusitis (HP:0011108)4.36106282
13Decreased circulating renin level (HP:0003351)4.10221735
14Pancreatic fibrosis (HP:0100732)3.97305690
15Hyperinsulinemic hypoglycemia (HP:0000825)3.86001140
16Recurrent otitis media (HP:0000403)3.74443358
17Bronchiectasis (HP:0002110)3.69558879
18True hermaphroditism (HP:0010459)3.55490151
19Hyperactive renin-angiotensin system (HP:0000841)3.26176169
20Visual hallucinations (HP:0002367)3.21884854
21Cystic liver disease (HP:0006706)3.19248014
22Tubulointerstitial nephritis (HP:0001970)3.14946994
23Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.04840618
24Hyperkalemia (HP:0002153)3.04533101
25Molar tooth sign on MRI (HP:0002419)3.02014650
26Abnormality of midbrain morphology (HP:0002418)3.02014650
27Nephronophthisis (HP:0000090)3.00470222
28Hypoglycemic seizures (HP:0002173)2.93680573
29Pancreatic cysts (HP:0001737)2.88025997
30Febrile seizures (HP:0002373)2.87611486
31Chronic otitis media (HP:0000389)2.87325396
32Gait imbalance (HP:0002141)2.80634325
33Genetic anticipation (HP:0003743)2.80078575
34Medial flaring of the eyebrow (HP:0010747)2.79920438
35Progressive cerebellar ataxia (HP:0002073)2.74599034
36Symptomatic seizures (HP:0011145)2.71165273
37Congenital primary aphakia (HP:0007707)2.67164359
38Occipital encephalocele (HP:0002085)2.60661240
39Abnormality of renin-angiotensin system (HP:0000847)2.57953707
40Median cleft lip (HP:0000161)2.51737903
41Focal seizures (HP:0007359)2.51231654
42Agitation (HP:0000713)2.48240975
43Insulin-resistant diabetes mellitus (HP:0000831)2.47850884
44Hyperglycemia (HP:0003074)2.45001765
45Abnormality of calcium-phosphate metabolism (HP:0100530)2.43933125
46Abnormality of the renal medulla (HP:0100957)2.43562715
47Congenital hepatic fibrosis (HP:0002612)2.40794899
48Bony spicule pigmentary retinopathy (HP:0007737)2.38702561
49Nephrogenic diabetes insipidus (HP:0009806)2.36666037
50Increased circulating renin level (HP:0000848)2.35911481
51Myokymia (HP:0002411)2.30422334
52Chronic sinusitis (HP:0011109)2.28617838
53Epileptic encephalopathy (HP:0200134)2.25486452
54Genital tract atresia (HP:0001827)2.24152209
55Epileptiform EEG discharges (HP:0011182)2.21556860
56Chronic hepatic failure (HP:0100626)2.20512041
57Recurrent bronchitis (HP:0002837)2.17415016
58Postaxial foot polydactyly (HP:0001830)2.15915443
59Bronchitis (HP:0012387)2.15867890
60Ketoacidosis (HP:0001993)2.15766212
61Abnormality of macular pigmentation (HP:0008002)2.12354594
62Vaginal atresia (HP:0000148)2.10899144
63Male infertility (HP:0003251)2.09320787
64Abnormality of dentin (HP:0010299)2.08752707
65Anencephaly (HP:0002323)2.07177398
66Absent rod-and cone-mediated responses on ERG (HP:0007688)2.01905247
67Hyperaldosteronism (HP:0000859)1.99377208
68EEG with generalized epileptiform discharges (HP:0011198)1.99222170
69Tubular atrophy (HP:0000092)1.98685020
70Tubulointerstitial abnormality (HP:0001969)1.98466659
71Aplasia/Hypoplasia of the tongue (HP:0010295)1.98187736
72Abnormality of potassium homeostasis (HP:0011042)1.98062707
73Bell-shaped thorax (HP:0001591)1.96689759
74Infertility (HP:0000789)1.95631994
75Aplasia/Hypoplasia of the lens (HP:0008063)1.93307499
76Poor coordination (HP:0002370)1.93272130
77Abnormality of the fovea (HP:0000493)1.91274578
78Generalized tonic-clonic seizures (HP:0002069)1.90938601
79Postaxial hand polydactyly (HP:0001162)1.89033754
80Hypsarrhythmia (HP:0002521)1.88165429
81Central scotoma (HP:0000603)1.87983297
82Hyperphosphatemia (HP:0002905)1.85513218
83Decreased central vision (HP:0007663)1.85503511
84Aplasia/Hypoplasia of the spleen (HP:0010451)1.83293590
85Sclerocornea (HP:0000647)1.82978198
86Polydipsia (HP:0001959)1.79959593
87Abnormal drinking behavior (HP:0030082)1.79959593
88Asplenia (HP:0001746)1.78619967
89Atelectasis (HP:0100750)1.77600004
90Bifid tongue (HP:0010297)1.76156071
91Bile duct proliferation (HP:0001408)1.75171659
92Abnormal biliary tract physiology (HP:0012439)1.75171659
93Furrowed tongue (HP:0000221)1.75124978
94Male pseudohermaphroditism (HP:0000037)1.74819550
95Nasal polyposis (HP:0100582)1.73273914
96Oculomotor apraxia (HP:0000657)1.72804936
97Preaxial hand polydactyly (HP:0001177)1.72242032
98Atonic seizures (HP:0010819)1.71976583
99Facial cleft (HP:0002006)1.71931524
100Renal salt wasting (HP:0000127)1.71720700
101Amblyopia (HP:0000646)1.71493281
102Abnormality of the dental root (HP:0006486)1.71258972
103Taurodontia (HP:0000679)1.71258972
104Abnormality of permanent molar morphology (HP:0011071)1.71258972
105Abnormal rod and cone electroretinograms (HP:0008323)1.71203171
106Hypoglycemic coma (HP:0001325)1.68603177
107Hemiparesis (HP:0001269)1.67300658
108Abnormality of the dental pulp (HP:0006479)1.67168246
109Absent frontal sinuses (HP:0002688)1.66748407
110Nephropathy (HP:0000112)1.66229141
111Supranuclear gaze palsy (HP:0000605)1.62416837
112Absence seizures (HP:0002121)1.61931597
113Stage 5 chronic kidney disease (HP:0003774)1.61903328
114Congenital glaucoma (HP:0001087)1.61672480
115Adrenal overactivity (HP:0002717)1.59259911
116Hypokalemia (HP:0002900)1.58813918
117Abnormality of molar (HP:0011077)1.58552714
118Cone-rod dystrophy (HP:0000548)1.42808557
119Abnormality of chloride homeostasis (HP:0011422)1.32229104
120Hypokalemic alkalosis (HP:0001949)1.32012192
121Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.28857554
122Abnormality of the renal cortex (HP:0011035)1.25810122
123Short thorax (HP:0010306)1.22100287
124Supernumerary spleens (HP:0009799)1.21437689
125Retinitis pigmentosa (HP:0000510)1.18107452
126Glucose intolerance (HP:0000833)1.08620850
127Tubulointerstitial fibrosis (HP:0005576)1.08466605
128Abnormality of the frontal sinuses (HP:0002687)1.05378049
129Absent speech (HP:0001344)1.04836411
130Narrow forehead (HP:0000341)1.02696938
131Bifid scrotum (HP:0000048)1.01643889
132Abnormality of molar morphology (HP:0011070)1.01426066
133Fetal akinesia sequence (HP:0001989)1.00310081
134Prominent nasal bridge (HP:0000426)0.99929152
135Hyponatremia (HP:0002902)0.98879918
136Aplasia/Hypoplasia involving the sinuses (HP:0009120)0.97903290
137Hand muscle atrophy (HP:0009130)0.97736053
138Aganglionic megacolon (HP:0002251)0.96639498
139Multicystic kidney dysplasia (HP:0000003)0.95826881

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK37.02006688
2MST45.90273749
3MAPK155.10408349
4EPHA44.39959629
5EPHA24.08737493
6INSRR2.88329054
7MAP2K72.63721313
8MAP3K42.55382041
9TNIK2.47017599
10MAPKAPK32.26666619
11PNCK2.15487376
12BCR1.96744165
13MAP3K21.79186162
14LATS11.69628635
15PRKD31.68149807
16FER1.67193178
17BMPR21.66772597
18FES1.60592011
19STK241.49971935
20GRK11.48551292
21MAP3K61.48034908
22NTRK21.44740799
23MAPK131.44492356
24MARK11.43059025
25TTK1.39922663
26DAPK21.39169256
27EPHA31.38595190
28HIPK21.37581092
29CDC42BPA1.28158994
30MAP3K91.25820208
31TLK11.25668822
32EPHB11.25013427
33CAMK2B1.19886654
34MAP4K21.19073064
35ADRBK21.14044703
36CSK1.12920302
37ARAF1.11490889
38GRK51.10768890
39STK381.10565818
40EEF2K1.09443471
41PAK61.09148488
42MAP3K31.07480154
43MAP2K41.06029886
44PINK11.04665784
45MAP3K71.01276226
46PASK1.01085820
47LATS20.98593365
48CAMK2A0.97188381
49DYRK1A0.97067111
50PAK30.95907188
51TRPM70.94710742
52PRKCG0.94693864
53PRPF4B0.92717407
54MINK10.91909728
55SMG10.88595085
56CDK50.87862936
57ERBB20.86837041
58CAMK2D0.86682903
59STK100.86430006
60KSR20.84772712
61PLK20.82629849
62KSR10.82098823
63SGK20.79629648
64PRKCE0.79041515
65DMPK0.78690728
66NTRK10.78553849
67LRRK20.77382012
68DAPK10.77230165
69WNK30.76477306
70IRAK10.76210962
71BRAF0.73857353
72FRK0.70411561
73CAMKK10.70240819
74OXSR10.68432428
75MARK20.67868278
76MST1R0.66921723
77CDK80.65417683
78SGK4940.63829165
79SGK2230.63829165
80RIPK40.63301172
81SGK10.63300268
82TAOK30.63267896
83NLK0.62350160
84BMPR1B0.61230732
85CASK0.60887442
86CDK30.60243014
87ADRBK10.59609795
88STK390.59516479
89RPS6KA20.58278380
90BRSK20.58100767
91PRKD20.57621900
92RIPK10.56952782
93CAMK1G0.56424203
94AKT30.55864473
95TBK10.53160120
96MAP3K10.53015388
97PTK20.50964837
98STK160.50401836
99RET0.50155954
100STK38L0.49647681
101PTK2B0.49009737
102TAOK10.48730601
103MUSK0.48272218
104PRKAA20.46169108
105CAMK2G0.45790940
106TESK10.45466200
107GRK70.45398949
108PRKCH0.44665854
109TSSK60.42332572
110CAMK10.41520057
111ERBB30.40870201
112NME10.40431472
113ACVR1B0.40004116
114PRKCI0.39947883
115CAMKK20.38109811
116PRKCD0.38004232
117PRKACA0.37177728
118PHKG10.37110345
119PHKG20.37110345
120AURKA0.36801169
121FGR0.36214283
122NEK60.35779066
123UHMK10.35759615
124MAPKAPK50.35598576
125CSNK1G20.33851613
126DYRK1B0.33468180
127PRKCA0.32668014
128ABL10.32444141
129WNK40.32216344
130RPS6KA30.31908241
131SGK30.31636439
132ERBB40.31381789
133PRKG10.31112951
134MAPK100.30664889
135ABL20.30313563
136CDK90.29786874
137TYRO30.29707418
138PRKCQ0.28150829
139PDPK10.27361797
140LMTK20.26197654
141MET0.24636351
142PRKCZ0.22948203
143MAP3K120.21821359
144CHUK0.21688271
145ROCK10.20784766
146AKT20.19700025
147MAP2K20.19618454
148EGFR0.17928503
149MAP2K10.17196313
150ROCK20.15971657
151PRKDC0.15751117
152PRKAA10.14719703
153SRC0.14071154
154IGF1R0.13831936

Predicted pathways (KEGG)

RankGene SetZ-score
1Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009805.11178016
2Histidine metabolism_Homo sapiens_hsa003404.37620210
3Chemical carcinogenesis_Homo sapiens_hsa052044.27793797
4Phenylalanine metabolism_Homo sapiens_hsa003604.18064100
5Drug metabolism - cytochrome P450_Homo sapiens_hsa009824.10192016
6Maturity onset diabetes of the young_Homo sapiens_hsa049503.58061324
7Tyrosine metabolism_Homo sapiens_hsa003503.30580972
8Nicotine addiction_Homo sapiens_hsa050333.22116571
9beta-Alanine metabolism_Homo sapiens_hsa004102.97137433
10Insulin secretion_Homo sapiens_hsa049112.78110734
11Circadian entrainment_Homo sapiens_hsa047132.69590967
12Amphetamine addiction_Homo sapiens_hsa050312.64315889
13Caffeine metabolism_Homo sapiens_hsa002322.58548645
14Huntingtons disease_Homo sapiens_hsa050162.51626223
15Glutamatergic synapse_Homo sapiens_hsa047242.43253190
16Taste transduction_Homo sapiens_hsa047422.37838700
17Long-term potentiation_Homo sapiens_hsa047202.35744622
18GABAergic synapse_Homo sapiens_hsa047272.33182700
19Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.32501557
20Phototransduction_Homo sapiens_hsa047442.30701974
21Linoleic acid metabolism_Homo sapiens_hsa005912.30631542
22Retinol metabolism_Homo sapiens_hsa008302.28318426
23Glutathione metabolism_Homo sapiens_hsa004802.25377398
24Olfactory transduction_Homo sapiens_hsa047402.14105481
25Synaptic vesicle cycle_Homo sapiens_hsa047212.11382304
26Type II diabetes mellitus_Homo sapiens_hsa049302.06654636
27Morphine addiction_Homo sapiens_hsa050321.99844460
28Dopaminergic synapse_Homo sapiens_hsa047281.98933293
29Cocaine addiction_Homo sapiens_hsa050301.97542798
30Serotonergic synapse_Homo sapiens_hsa047261.75228125
31Aldosterone synthesis and secretion_Homo sapiens_hsa049251.74791404
32Circadian rhythm_Homo sapiens_hsa047101.71567195
33Sphingolipid metabolism_Homo sapiens_hsa006001.67570232
34Cholinergic synapse_Homo sapiens_hsa047251.63627689
35Steroid hormone biosynthesis_Homo sapiens_hsa001401.61204883
36Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.54295044
37Salivary secretion_Homo sapiens_hsa049701.54032087
38Gastric acid secretion_Homo sapiens_hsa049711.50008540
39Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.44560579
40Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.39902724
41Calcium signaling pathway_Homo sapiens_hsa040201.38825903
42cAMP signaling pathway_Homo sapiens_hsa040241.38429002
43Long-term depression_Homo sapiens_hsa047301.38057248
44GnRH signaling pathway_Homo sapiens_hsa049121.32310134
45Peroxisome_Homo sapiens_hsa041461.29263202
46Estrogen signaling pathway_Homo sapiens_hsa049151.28917425
47Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.28310440
48Vibrio cholerae infection_Homo sapiens_hsa051101.27294483
49Collecting duct acid secretion_Homo sapiens_hsa049661.25306743
50Renin secretion_Homo sapiens_hsa049241.24990871
51Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.22994715
52Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.22804605
53Fatty acid degradation_Homo sapiens_hsa000711.22471863
54Pancreatic secretion_Homo sapiens_hsa049721.19574822
55Arachidonic acid metabolism_Homo sapiens_hsa005901.17404087
56Oxytocin signaling pathway_Homo sapiens_hsa049211.15754838
57Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.12721331
58Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.09627752
59Carbohydrate digestion and absorption_Homo sapiens_hsa049731.08244068
60Thyroid hormone synthesis_Homo sapiens_hsa049181.08053155
61Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.07047815
62Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.04635728
63Phosphatidylinositol signaling system_Homo sapiens_hsa040701.03336594
64cGMP-PKG signaling pathway_Homo sapiens_hsa040221.00520709
65Type I diabetes mellitus_Homo sapiens_hsa049400.99279532
66Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.97721854
67Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.95674924
68Protein export_Homo sapiens_hsa030600.90847517
69Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.90735790
70Ovarian steroidogenesis_Homo sapiens_hsa049130.90198779
71Vascular smooth muscle contraction_Homo sapiens_hsa042700.87925837
72Glucagon signaling pathway_Homo sapiens_hsa049220.86586408
73Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.86549115
74Choline metabolism in cancer_Homo sapiens_hsa052310.86053754
75Axon guidance_Homo sapiens_hsa043600.85810141
76Primary bile acid biosynthesis_Homo sapiens_hsa001200.85780974
77Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.83258887
78Melanogenesis_Homo sapiens_hsa049160.81036917
79Starch and sucrose metabolism_Homo sapiens_hsa005000.80755300
80Nitrogen metabolism_Homo sapiens_hsa009100.80050833
81ErbB signaling pathway_Homo sapiens_hsa040120.75407035
82Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.74733183
83Dorso-ventral axis formation_Homo sapiens_hsa043200.74321952
84Gap junction_Homo sapiens_hsa045400.74155006
85Pentose and glucuronate interconversions_Homo sapiens_hsa000400.68504991
86Tryptophan metabolism_Homo sapiens_hsa003800.66965573
87Butanoate metabolism_Homo sapiens_hsa006500.65464240
88Ras signaling pathway_Homo sapiens_hsa040140.64451518
89Wnt signaling pathway_Homo sapiens_hsa043100.63677780
90Prion diseases_Homo sapiens_hsa050200.63487143
91Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.61096446
92Drug metabolism - other enzymes_Homo sapiens_hsa009830.60394200
93Prolactin signaling pathway_Homo sapiens_hsa049170.59383595
94MAPK signaling pathway_Homo sapiens_hsa040100.58663659
95Phospholipase D signaling pathway_Homo sapiens_hsa040720.53948579
96Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.52816563
97Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.51362751
98Glioma_Homo sapiens_hsa052140.51221738
99Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.50283668
100Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.49821049
101Inositol phosphate metabolism_Homo sapiens_hsa005620.49120476
102Cyanoamino acid metabolism_Homo sapiens_hsa004600.46860301
103Dilated cardiomyopathy_Homo sapiens_hsa054140.45690198
104Glycerophospholipid metabolism_Homo sapiens_hsa005640.43152863
105Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.42186672
106Alcoholism_Homo sapiens_hsa050340.42023521
107Notch signaling pathway_Homo sapiens_hsa043300.41564120
108Endometrial cancer_Homo sapiens_hsa052130.40762289
109Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.40536111
110Arginine and proline metabolism_Homo sapiens_hsa003300.40489261
111Mineral absorption_Homo sapiens_hsa049780.40459863
112Sulfur metabolism_Homo sapiens_hsa009200.39868604
113Glycerolipid metabolism_Homo sapiens_hsa005610.39405806
114Longevity regulating pathway - mammal_Homo sapiens_hsa042110.38960758
115Metabolic pathways_Homo sapiens_hsa011000.38846283
116Ether lipid metabolism_Homo sapiens_hsa005650.38344493
117PPAR signaling pathway_Homo sapiens_hsa033200.38200089
118Hematopoietic cell lineage_Homo sapiens_hsa046400.37044850
119Insulin signaling pathway_Homo sapiens_hsa049100.36945942
120Thyroid hormone signaling pathway_Homo sapiens_hsa049190.36881695
121Basal cell carcinoma_Homo sapiens_hsa052170.36541714
122Oocyte meiosis_Homo sapiens_hsa041140.36404076
123VEGF signaling pathway_Homo sapiens_hsa043700.36145598
124Neurotrophin signaling pathway_Homo sapiens_hsa047220.35230534
125Transcriptional misregulation in cancer_Homo sapiens_hsa052020.34649533
126Complement and coagulation cascades_Homo sapiens_hsa046100.34424144
127Leukocyte transendothelial migration_Homo sapiens_hsa046700.33825353
128Hepatitis C_Homo sapiens_hsa051600.33745818
129Intestinal immune network for IgA production_Homo sapiens_hsa046720.32494760
130Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.31921266
131Vitamin digestion and absorption_Homo sapiens_hsa049770.31599065
132Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.31247991
133Fatty acid biosynthesis_Homo sapiens_hsa000610.30783188
134Bile secretion_Homo sapiens_hsa049760.30419659
135Rap1 signaling pathway_Homo sapiens_hsa040150.29936513
136Insulin resistance_Homo sapiens_hsa049310.29074856
137Regulation of autophagy_Homo sapiens_hsa041400.29025926
138Adherens junction_Homo sapiens_hsa045200.28758393
139mTOR signaling pathway_Homo sapiens_hsa041500.27896883
140Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.27562016
141Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.27545241
142Hedgehog signaling pathway_Homo sapiens_hsa043400.27284796
143Asthma_Homo sapiens_hsa053100.26143338
144ABC transporters_Homo sapiens_hsa020100.25591252
145Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.25559738
146Tight junction_Homo sapiens_hsa045300.24897361
147Rheumatoid arthritis_Homo sapiens_hsa053230.24041724
148Hippo signaling pathway_Homo sapiens_hsa043900.22274724
149alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.21634526
150Allograft rejection_Homo sapiens_hsa053300.20370719
151Jak-STAT signaling pathway_Homo sapiens_hsa046300.19569815
152Glycosaminoglycan degradation_Homo sapiens_hsa005310.19327578
153Propanoate metabolism_Homo sapiens_hsa006400.19210765
154Autoimmune thyroid disease_Homo sapiens_hsa053200.18181280

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