ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	left/right pattern formation (GO:0060972)	9.29364311
2	regulation of cilium movement (GO:0003352)	8.32857049
3	left/right axis specification (GO:0070986)	7.35962462
4	ventricular system development (GO:0021591)	6.94134045
5	primary alcohol catabolic process (GO:0034310)	6.87956382
6	intraciliary transport (GO:0042073)	6.77368245
7	microtubule bundle formation (GO:0001578)	6.44202513
8	cilium organization (GO:0044782)	6.42640310
9	cilium assembly (GO:0042384)	6.25035725
10	vitamin transmembrane transport (GO:0035461)	6.17499267
11	ethanol metabolic process (GO:0006067)	5.79035756
12	protein localization to cilium (GO:0061512)	5.46558760
13	diterpenoid biosynthetic process (GO:0016102)	5.44691690
14	regulation of microtubule-based movement (GO:0060632)	5.01237040
15	centriole assembly (GO:0098534)	4.97387522
16	cellular component assembly involved in morphogenesis (GO:0010927)	4.94795268
17	cilium morphogenesis (GO:0060271)	4.82640781
18	one-carbon compound transport (GO:0019755)	4.78162892
19	lung epithelium development (GO:0060428)	4.76292245
20	response to xenobiotic stimulus (GO:0009410)	4.74066134
21	pyrimidine-containing compound transmembrane transport (GO:0072531)	4.73087155
22	* microtubule-based movement (GO:0007018)	4.72087802
23	tolerance induction (GO:0002507)	4.70475562
24	negative regulation of T cell differentiation in thymus (GO:0033085)	4.66298455
25	glomerular epithelial cell development (GO:0072310)	4.51506443
26	cell projection assembly (GO:0030031)	4.42323649
27	establishment of apical/basal cell polarity (GO:0035089)	4.36722064
28	ethanol oxidation (GO:0006069)	4.35103562
29	sperm capacitation (GO:0048240)	4.33616253
30	negative regulation of immunoglobulin mediated immune response (GO:0002890)	4.26155384
31	negative regulation of B cell mediated immunity (GO:0002713)	4.26155384
32	regulation of interleukin-5 production (GO:0032674)	4.18599351
33	negative regulation of humoral immune response (GO:0002921)	4.10001392
34	negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)	3.97619525
35	retinoic acid metabolic process (GO:0042573)	3.93576950
36	establishment of monopolar cell polarity (GO:0061162)	3.93035659
37	establishment or maintenance of monopolar cell polarity (GO:0061339)	3.93035659
38	terpenoid biosynthetic process (GO:0016114)	3.92661003
39	lateral ventricle development (GO:0021670)	3.91961704
40	cytoplasmic microtubule organization (GO:0031122)	3.88424364
41	nucleoside diphosphate phosphorylation (GO:0006165)	3.85774996
42	negative regulation of inclusion body assembly (GO:0090084)	3.75029749
43	regulation of interleukin-13 production (GO:0032656)	3.74040374
44	regulation of germinal center formation (GO:0002634)	3.65202221
45	microtubule depolymerization (GO:0007019)	3.61641921
46	positive regulation of tolerance induction (GO:0002645)	3.57739483
47	microtubule polymerization or depolymerization (GO:0031109)	3.46090949
48	establishment of planar polarity (GO:0001736)	3.38338632
49	establishment of tissue polarity (GO:0007164)	3.38338632
50	determination of left/right symmetry (GO:0007368)	3.36485718
51	exogenous drug catabolic process (GO:0042738)	3.27240764
52	determination of bilateral symmetry (GO:0009855)	3.24428744
53	retinol metabolic process (GO:0042572)	3.21568054
54	sperm motility (GO:0030317)	3.20585502
55	glutathione derivative biosynthetic process (GO:1901687)	3.17676635
56	glutathione derivative metabolic process (GO:1901685)	3.17676635
57	specification of symmetry (GO:0009799)	3.17379436
58	primary alcohol metabolic process (GO:0034308)	3.13826521
59	smoothened signaling pathway (GO:0007224)	3.11401935
60	hydrogen peroxide biosynthetic process (GO:0050665)	3.05830351
61	retinal rod cell development (GO:0046548)	3.02344009
62	positive regulation of smoothened signaling pathway (GO:0045880)	3.00896744
63	aldehyde catabolic process (GO:0046185)	3.00007445
64	axonemal dynein complex assembly (GO:0070286)	21.8111266
65	O-glycan processing (GO:0016266)	2.99193378
66	centriole replication (GO:0007099)	2.97227648
67	lateral sprouting from an epithelium (GO:0060601)	2.94146948
68	* microtubule-based process (GO:0007017)	2.84800610
69	organelle assembly (GO:0070925)	2.78794560
70	regulation of microtubule depolymerization (GO:0031114)	2.71795491
71	reactive oxygen species biosynthetic process (GO:1903409)	2.70018472
72	apical protein localization (GO:0045176)	2.69377025
73	carnitine metabolic process (GO:0009437)	2.64956712
74	nonmotile primary cilium assembly (GO:0035058)	2.62598453
75	heart looping (GO:0001947)	2.58973502
76	phosphatidylcholine biosynthetic process (GO:0006656)	2.57834633
77	regulation of tolerance induction (GO:0002643)	2.57040405
78	excretion (GO:0007588)	2.56920316
79	multicellular organismal water homeostasis (GO:0050891)	2.54231667
80	phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)	2.54009371
81	drug catabolic process (GO:0042737)	2.52540736
82	regulation of autophagic vacuole assembly (GO:2000785)	2.46632080
83	photoreceptor cell maintenance (GO:0045494)	2.44697525
84	embryonic camera-type eye development (GO:0031076)	2.39957041
85	regulation of smoothened signaling pathway (GO:0008589)	2.38656358
86	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)	2.37415952
87	regulation of inclusion body assembly (GO:0090083)	2.35864647
88	retinal cone cell development (GO:0046549)	2.35371143
89	embryonic heart tube morphogenesis (GO:0003143)	2.34911352
90	progesterone metabolic process (GO:0042448)	2.34466379
91	regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)	2.34220800
92	oligosaccharide biosynthetic process (GO:0009312)	2.33757319
93	CDP-diacylglycerol biosynthetic process (GO:0016024)	2.31695750
94	hydrogen peroxide catabolic process (GO:0042744)	2.31099035
95	cilium or flagellum-dependent cell motility (GO:0001539)	19.0476892
96	* cilium movement (GO:0003341)	15.6446687
97	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	15.3039836
98	motile cilium assembly (GO:0044458)	14.7782190
99	* epithelial cilium movement (GO:0003351)	13.0789460
100	axoneme assembly (GO:0035082)	10.3351962

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	4.91689640
2	DROSHA_22980978_ChIP-Seq_HELA_Human	3.45602904
3	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	3.26403198
4	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.13044924
5	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	2.62539050
6	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.59099028
7	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.56995511
8	PIAS1_25552417_ChIP-Seq_VCAP_Human	2.05646597
9	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.96342960
10	VDR_22108803_ChIP-Seq_LS180_Human	1.94125219
11	AHR_22903824_ChIP-Seq_MCF-7_Human	1.90612121
12	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.90485070
13	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.78032204
14	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.73690971
15	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.71211874
16	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	1.69371282
17	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.65908988
18	TP63_23658742_ChIP-Seq_EP156T_Human	1.54536584
19	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.54534962
20	RUNX1_27514584_Chip-Seq_MCF-7_Human	1.53346077
21	STAT1_20625510_ChIP-Seq_HELA_Human	1.52975925
22	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.49820372
23	SMC4_20622854_ChIP-Seq_HELA_Human	1.48716771
24	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	1.48688928
25	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	1.46709881
26	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.45873440
27	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.45606758
28	ETV1_20927104_ChIP-Seq_GIST48_Human	1.42475592
29	TP53_18474530_ChIP-ChIP_U2OS_Human	1.42389522
30	SOX2_27498859_Chip-Seq_STOMACH_Mouse	1.42302025
31	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.39337645
32	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.38885690
33	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.38133112
34	KLF5_25053715_ChIP-Seq_YYC3_Human	1.36922178
35	FOXA1_25552417_ChIP-Seq_VCAP_Human	1.35318213
36	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.35029923
37	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.34860072
38	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	1.34811331
39	PHF8_20622853_ChIP-Seq_HELA_Human	1.34394796
40	SMAD4_21799915_ChIP-Seq_A2780_Human	1.32665368
41	TP63_22573176_ChIP-Seq_HFKS_Human	1.31257024
42	RAD21_21589869_ChIP-Seq_MESCs_Mouse	1.30193745
43	CDX2_20551321_ChIP-Seq_CACO-2_Human	1.30113779
44	CTNNB1_20460455_ChIP-Seq_HCT116_Human	1.28716110
45	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.28187259
46	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.27975904
47	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.27907391
48	SMRT_27268052_Chip-Seq_Bcells_Human	1.25616631
49	SOX2_20726797_ChIP-Seq_SW620_Human	1.19791846
50	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.19116003
51	RBPJ_21746931_ChIP-Seq_IB4_Human	1.18194206
52	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.17944392
53	SOX9_24532713_ChIP-Seq_HFSC_Mouse	1.15855651
54	P63_26484246_Chip-Seq_KERATINOCYTES_Human	1.15219857
55	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.14444831
56	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.13734434
57	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.12322122
58	NFYA_21822215_ChIP-Seq_K562_Human	1.11584296
59	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.11504700
60	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.10200528
61	TBL1_22424771_ChIP-Seq_293T_Human	1.09081711
62	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.08767303
63	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.07555785
64	NFYB_21822215_ChIP-Seq_K562_Human	1.07104880
65	CBX2_22325352_ChIP-Seq_293T-Rex_Human	1.06883720
66	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.06676747
67	SMAD3_21741376_ChIP-Seq_HESCs_Human	1.06409769
68	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.06158054
69	AR_21572438_ChIP-Seq_LNCaP_Human	1.05512562
70	CTCF_27219007_Chip-Seq_Bcells_Human	1.05393188
71	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.05133272
72	GATA4_25053715_ChIP-Seq_YYC3_Human	1.04161811
73	BCAT_22108803_ChIP-Seq_LS180_Human	1.03760996
74	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.02911866
75	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	1.01222417
76	TCF4_22108803_ChIP-Seq_LS180_Human	1.00896674
77	AR_20517297_ChIP-Seq_VCAP_Human	1.00324960
78	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.00296927
79	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.99592848
80	ELF1_20517297_ChIP-Seq_JURKAT_Human	0.99271683
81	TP53_16413492_ChIP-PET_HCT116_Human	0.99102678
82	* STAT3_23295773_ChIP-Seq_U87_Human	0.98834136
83	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.98700935
84	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.98700935
85	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.97738034
86	WDR5_24793694_ChIP-Seq_LNCAP_Human	0.97596556
87	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.96644924
88	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	0.96117268
89	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.95199284
90	CEBPB_22108803_ChIP-Seq_LS180_Human	0.94514515
91	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.93787714
92	CTCF_20526341_ChIP-Seq_ESCs_Human	0.93570226
93	FOXA1_26743006_Chip-Seq_LNCaP-abl_Human	0.93122537
94	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.91997137
95	FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human	0.90935322
96	PHF8_20622854_ChIP-Seq_HELA_Human	0.90644045
97	MYC_19829295_ChIP-Seq_ESCs_Human	0.90269319
98	GATA1_19941826_ChIP-Seq_K562_Human	0.89839023
99	* FOXA2_19822575_ChIP-Seq_HepG2_Human	0.89779747
100	ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human	0.89664900

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002653_abnormal_ependyma_morphology	6.92535434
2	MP0008875_abnormal_xenobiotic_pharmacok	6.26161926
3	MP0002132_abnormal_respiratory_system	4.59302960
4	MP0001984_abnormal_olfaction	4.22504800
5	MP0004133_heterotaxia	3.86071105
6	MP0004043_abnormal_pH_regulation	3.54072631
7	MP0005623_abnormal_meninges_morphology	3.51781405
8	MP0008789_abnormal_olfactory_epithelium	3.44846647
9	MP0009780_abnormal_chondrocyte_physiolo	3.41382033
10	MP0002277_abnormal_respiratory_mucosa	3.22835004
11	MP0000566_synostosis	3.20822489
12	MP0003878_abnormal_ear_physiology	3.03559972
13	MP0005377_hearing/vestibular/ear_phenot	3.03559972
14	MP0005499_abnormal_olfactory_system	2.40691590
15	MP0005394_taste/olfaction_phenotype	2.40691590
16	MP0000383_abnormal_hair_follicle	2.37904697
17	MP0004019_abnormal_vitamin_homeostasis	2.22397542
18	MP0002282_abnormal_trachea_morphology	2.14835039
19	MP0010678_abnormal_skin_adnexa	2.04989903
20	MP0002160_abnormal_reproductive_system	1.96911489
21	MP0002909_abnormal_adrenal_gland	1.78609949
22	MP0005248_abnormal_Harderian_gland	1.76507581
23	MP0002168_other_aberrant_phenotype	1.68632499
24	MP0010030_abnormal_orbit_morphology	1.64666111
25	MP0003136_yellow_coat_color	1.64340930
26	MP0001765_abnormal_ion_homeostasis	1.63459577
27	MP0002638_abnormal_pupillary_reflex	1.61351014
28	MP0001346_abnormal_lacrimal_gland	1.52821724
29	MP0003656_abnormal_erythrocyte_physiolo	1.48709941
30	MP0001485_abnormal_pinna_reflex	1.45679623
31	MP0005083_abnormal_biliary_tract	1.38713379
32	MP0002249_abnormal_larynx_morphology	1.36560763
33	MP0002734_abnormal_mechanical_nocicepti	1.34367415
34	MP0000678_abnormal_parathyroid_gland	1.30956764
35	MP0009046_muscle_twitch	1.22477097
36	MP0002233_abnormal_nose_morphology	1.22192892
37	MP0009379_abnormal_foot_pigmentation	1.16821978
38	MP0005636_abnormal_mineral_homeostasis	1.14860235
39	MP0002876_abnormal_thyroid_physiology	1.12088299
40	MP0010234_abnormal_vibrissa_follicle	1.11735244
41	MP0005395_other_phenotype	1.09485931
42	MP0001293_anophthalmia	1.09087095
43	MP0000026_abnormal_inner_ear	1.06838573
44	MP0002928_abnormal_bile_duct	1.06487451
45	MP0005253_abnormal_eye_physiology	1.04390856
46	MP0005389_reproductive_system_phenotype	0.98535095
47	MP0001270_distended_abdomen	0.95240956
48	MP0003698_abnormal_male_reproductive	0.93143382
49	MP0005551_abnormal_eye_electrophysiolog	0.92069419
50	MP0005408_hypopigmentation	0.90186949
51	MP0001929_abnormal_gametogenesis	0.90046028
52	MP0005365_abnormal_bile_salt	0.87811860
53	MP0005220_abnormal_exocrine_pancreas	0.81904001
54	MP0000631_abnormal_neuroendocrine_gland	0.78643586
55	MP0005646_abnormal_pituitary_gland	0.77725296
56	MP0001324_abnormal_eye_pigmentation	0.77220936
57	MP0002735_abnormal_chemical_nociception	0.77128937
58	MP0005165_increased_susceptibility_to	0.75798492
59	MP0004264_abnormal_extraembryonic_tissu	0.74739064
60	MP0001944_abnormal_pancreas_morphology	0.73418404
61	MP0001963_abnormal_hearing_physiology	0.73045589
62	MP0000681_abnormal_thyroid_gland	0.72897268
63	MP0005391_vision/eye_phenotype	0.71262522
64	MP0003937_abnormal_limbs/digits/tail_de	0.68965428
65	MP0001502_abnormal_circadian_rhythm	0.68300706
66	MP0003890_abnormal_embryonic-extraembry	0.68275286
67	MP0005195_abnormal_posterior_eye	0.67488995
68	MP0009643_abnormal_urine_homeostasis	0.65253526
69	MP0002229_neurodegeneration	0.64974271
70	MP0000465_gastrointestinal_hemorrhage	0.64166454
71	MP0001299_abnormal_eye_distance/	0.62718671
72	MP0010155_abnormal_intestine_physiology	0.62105429
73	MP0003938_abnormal_ear_development	0.61818558
74	MP0002098_abnormal_vibrissa_morphology	0.60317894
75	MP0002136_abnormal_kidney_physiology	0.58819719
76	MP0002116_abnormal_craniofacial_bone	0.58550121
77	MP0009703_decreased_birth_body	0.57839236
78	MP0002139_abnormal_hepatobiliary_system	0.57205663
79	MP0003879_abnormal_hair_cell	0.57061511
80	MP0000049_abnormal_middle_ear	0.56702143
81	MP0001664_abnormal_digestion	0.55082948
82	MP0001486_abnormal_startle_reflex	0.54630269
83	MP0005187_abnormal_penis_morphology	0.54440833
84	MP0001970_abnormal_pain_threshold	0.54388804
85	MP0003861_abnormal_nervous_system	0.53308313
86	MP0004883_abnormal_blood_vessel	0.52735478
87	MP0005164_abnormal_response_to	0.52373024
88	MP0005085_abnormal_gallbladder_physiolo	0.51980910
89	MP0000955_abnormal_spinal_cord	0.50026307
90	MP0005409_darkened_coat_color	0.49447783
91	MP0006072_abnormal_retinal_apoptosis	0.49103106
92	MP0004885_abnormal_endolymph	0.49084034
93	MP0003283_abnormal_digestive_organ	0.47373817
94	MP0002092_abnormal_eye_morphology	0.45892565
95	MP0002161_abnormal_fertility/fecundity	0.45631925
96	MP0002557_abnormal_social/conspecific_i	0.44125979
97	MP0002572_abnormal_emotion/affect_behav	0.44054772
98	MP0004270_analgesia	0.43760790
99	MP0002752_abnormal_somatic_nervous	0.40614856
100	MP0008872_abnormal_physiological_respon	0.40576260

Predicted human phenotypes

Rank	Gene Set	Z-score
1	* Rhinitis (HP:0012384)	9.76732567
2	Chronic bronchitis (HP:0004469)	7.89091019
3	* Bronchiectasis (HP:0002110)	7.29562567
4	* Nasal polyposis (HP:0100582)	5.48633142
5	Recurrent sinusitis (HP:0011108)	4.45154135
6	* Abnormality of the nasal mucosa (HP:0000433)	4.44525733
7	Bronchitis (HP:0012387)	4.40152422
8	Occipital encephalocele (HP:0002085)	3.98754530
9	* Infertility (HP:0000789)	3.97276369
10	True hermaphroditism (HP:0010459)	3.94535781
11	Pancreatic fibrosis (HP:0100732)	3.93785948
12	Recurrent otitis media (HP:0000403)	3.90777365
13	Abnormality of midbrain morphology (HP:0002418)	3.32237358
14	Molar tooth sign on MRI (HP:0002419)	3.32237358
15	Pancreatic cysts (HP:0001737)	3.24828077
16	Cystic liver disease (HP:0006706)	3.20218921
17	Nephronophthisis (HP:0000090)	3.16608829
18	Atelectasis (HP:0100750)	3.11550901
19	* Chronic sinusitis (HP:0011109)	2.96195219
20	Chronic hepatic failure (HP:0100626)	2.92833268
21	Hyperactive renin-angiotensin system (HP:0000841)	2.82753235
22	Postaxial foot polydactyly (HP:0001830)	2.74073548
23	Abnormality of the renal medulla (HP:0100957)	2.47355294
24	Tubulointerstitial nephritis (HP:0001970)	2.41647492
25	Congenital hepatic fibrosis (HP:0002612)	2.32065187
26	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.29477528
27	Medial flaring of the eyebrow (HP:0010747)	2.26706361
28	Anencephaly (HP:0002323)	2.22195626
29	Bell-shaped thorax (HP:0001591)	2.21382069
30	* Male infertility (HP:0003251)	2.12805436
31	Congenital primary aphakia (HP:0007707)	2.12562581
32	Gait imbalance (HP:0002141)	2.10133321
33	Male pseudohermaphroditism (HP:0000037)	2.09466165
34	Tubular atrophy (HP:0000092)	2.02094933
35	Recurrent bronchitis (HP:0002837)	2.00257136
36	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	12.8380687
37	Dynein arm defect of respiratory motile cilia (HP:0012255)	11.4862201
38	Absent/shortened dynein arms (HP:0200106)	11.4862201
39	* Abnormal respiratory epithelium morphology (HP:0012253)	10.9681208
40	* Abnormal respiratory motile cilium morphology (HP:0005938)	10.9681208
41	* Abnormal respiratory motile cilium physiology (HP:0012261)	10.9500746
42	* Abnormal ciliary motility (HP:0012262)	10.6231785
43	Sclerocornea (HP:0000647)	1.90866328
44	Furrowed tongue (HP:0000221)	1.86238603
45	Postaxial hand polydactyly (HP:0001162)	1.85539040
46	Oculomotor apraxia (HP:0000657)	1.85243491
47	Nephrogenic diabetes insipidus (HP:0009806)	1.84783554
48	Decreased circulating renin level (HP:0003351)	1.80338257
49	Renal salt wasting (HP:0000127)	1.71462272
50	Nephropathy (HP:0000112)	1.69499108
51	Hyperkalemia (HP:0002153)	1.58334518
52	Preaxial hand polydactyly (HP:0001177)	1.54614781
53	Median cleft lip (HP:0000161)	1.52425028
54	Genital tract atresia (HP:0001827)	1.50696347
55	Vaginal atresia (HP:0000148)	1.49881009
56	Poor coordination (HP:0002370)	1.48802177
57	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.44760176
58	Tubulointerstitial abnormality (HP:0001969)	1.43795343
59	Hyperaldosteronism (HP:0000859)	1.38515674
60	Abnormality of renin-angiotensin system (HP:0000847)	1.34336006
61	Stage 5 chronic kidney disease (HP:0003774)	1.34209530
62	Bifid scrotum (HP:0000048)	1.32667447
63	Short thorax (HP:0010306)	1.30271617
64	Abnormality of the dental root (HP:0006486)	1.29948190
65	Taurodontia (HP:0000679)	1.29948190
66	Abnormality of permanent molar morphology (HP:0011071)	1.29948190
67	Abnormality of chloride homeostasis (HP:0011422)	1.29676551
68	Abnormal drinking behavior (HP:0030082)	1.24825832
69	Polydipsia (HP:0001959)	1.24825832
70	Supernumerary spleens (HP:0009799)	1.23022213
71	Decreased central vision (HP:0007663)	1.19795181
72	Bile duct proliferation (HP:0001408)	1.19525220
73	Abnormal biliary tract physiology (HP:0012439)	1.19525220
74	Abnormality of molar morphology (HP:0011070)	1.18363512
75	Abnormality of molar (HP:0011077)	1.18363512
76	Hand muscle atrophy (HP:0009130)	1.16742159
77	Abnormality of the dental pulp (HP:0006479)	1.15824626
78	Short nail (HP:0001799)	1.14030540
79	Fetal akinesia sequence (HP:0001989)	1.11477162
80	Abnormality of the renal cortex (HP:0011035)	1.11374404
81	Hypokalemic alkalosis (HP:0001949)	1.11317977
82	Retinitis pigmentosa (HP:0000510)	1.11260638
83	Cone-rod dystrophy (HP:0000548)	1.11143519
84	Absent speech (HP:0001344)	1.10547742
85	Glucose intolerance (HP:0000833)	1.09697134
86	Narrow forehead (HP:0000341)	1.07849504
87	Abnormality of the distal phalanges of the toes (HP:0010182)	1.07772744
88	Tubulointerstitial fibrosis (HP:0005576)	1.07587837
89	Prominent nasal bridge (HP:0000426)	1.03798010
90	Short femoral neck (HP:0100864)	1.02209521
91	Multicystic kidney dysplasia (HP:0000003)	1.01114548
92	Aganglionic megacolon (HP:0002251)	1.00922748
93	Abnormality of macular pigmentation (HP:0008002)	1.00730264
94	Aplasia/Hypoplasia of the lens (HP:0008063)	1.00484406
95	Abnormal rod and cone electroretinograms (HP:0008323)	1.00025019
96	Hyponatremia (HP:0002902)	0.99988650
97	Abnormality of dentin (HP:0010299)	0.99638206
98	Renal dysplasia (HP:0000110)	0.96573266
99	Abdominal situs inversus (HP:0003363)	0.95925155
100	Abnormality of abdominal situs (HP:0011620)	0.95925155

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MST4	5.25726945
2	EPHA2	4.33670103
3	MAPKAPK3	2.41691045
4	PNCK	2.11137332
5	NME1	2.01123815
6	MAPK15	12.1255923
7	PTK2B	1.93167455
8	STK24	1.79268209
9	MAP3K2	1.71845164
10	BCR	1.66749753
11	TTK	1.52586338
12	EEF2K	1.50870677
13	ERBB3	1.42812322
14	EPHB1	1.34756058
15	SMG1	1.25621294
16	CSK	1.23599184
17	EPHA3	1.15744558
18	NEK6	1.12165864
19	TSSK6	1.12085247
20	STK10	1.01814994
21	MAP3K3	1.00528280
22	TLK1	1.00066728
23	IRAK1	0.99854162
24	LRRK2	0.99242533
25	MAP3K4	0.97469347
26	MAP3K7	0.93516467
27	TRPM7	0.89413077
28	CAMKK1	0.87337528
29	MAP3K12	0.85232124
30	ERBB2	0.82531590
31	TESK1	0.82214293
32	PRKCI	0.79031636
33	MST1R	0.76852170
34	MARK2	0.76288078
35	STK16	0.67894757
36	CDK19	0.65038307
37	FRK	0.61306100
38	CAMKK2	0.60367206
39	BRSK2	0.59836205
40	MAP2K7	0.58130460
41	INSRR	0.55552898
42	LATS1	0.52926928
43	STK38	0.48321954
44	MAP2K4	0.48148012
45	PRKCQ	0.46380731
46	EPHA4	0.45942704
47	NLK	0.44082601
48	CAMK2G	0.43747147
49	DYRK1B	0.43645157
50	TBK1	0.42652216
51	PINK1	0.40255828
52	AURKA	0.39705046
53	MET	0.39539196
54	ADRBK1	0.39209029
55	GRK1	0.38836957
56	FER	0.38823781
57	MAPK13	0.38131591
58	SGK1	0.37733453
59	OXSR1	0.33025425
60	PRKAA2	0.32896068
61	PRKCD	0.31737758
62	STK38L	0.31346765
63	PRKACA	0.30927166
64	ROCK2	0.30836908
65	PDPK1	0.30755205
66	RIPK4	0.29022049
67	PLK1	0.28644784
68	NTRK3	0.28609794
69	MAPKAPK5	0.28600092
70	ADRBK2	0.27414747
71	ROCK1	0.26843966
72	MATK	0.25603614
73	ICK	0.25102457
74	AKT2	0.25020088
75	WEE1	0.24973921
76	PASK	0.24583344
77	PRKCA	0.24298310
78	PRKCH	0.23838182
79	CAMK2A	0.23449354
80	DYRK1A	0.23126597
81	MAP4K2	0.22724178
82	RPS6KB2	0.21562887
83	WNK3	0.21035307
84	ABL1	0.19966893
85	PRKD2	0.19654359
86	PAK3	0.18752911
87	GRK6	0.18418783
88	PTK6	0.18395419
89	WNK4	0.18352878
90	RET	0.18313559
91	SGK494	0.17914500
92	SGK223	0.17914500
93	YES1	0.17777673
94	PRKCE	0.17673126
95	PRKCZ	0.17618878
96	STK11	0.17095531
97	HIPK2	0.17066774
98	STK3	0.16024704
99	TAOK1	0.14907731
100	SRC	0.14828641

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	5.46094320
2	Phenylalanine metabolism_Homo sapiens_hsa00360	4.88579189
3	Histidine metabolism_Homo sapiens_hsa00340	4.65827818
4	Chemical carcinogenesis_Homo sapiens_hsa05204	4.43574889
5	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	4.26995925
6	Tyrosine metabolism_Homo sapiens_hsa00350	3.76139044
7	beta-Alanine metabolism_Homo sapiens_hsa00410	3.18709150
8	Huntingtons disease_Homo sapiens_hsa05016	2.63422856
9	Glutathione metabolism_Homo sapiens_hsa00480	2.49925966
10	Caffeine metabolism_Homo sapiens_hsa00232	2.31498985
11	Retinol metabolism_Homo sapiens_hsa00830	2.29355432
12	Linoleic acid metabolism_Homo sapiens_hsa00591	1.97256957
13	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	1.71860383
14	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.68800313
15	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.63657711
16	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.63648010
17	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.59794873
18	ABC transporters_Homo sapiens_hsa02010	1.54509789
19	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.45478336
20	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.44228977
21	Sphingolipid metabolism_Homo sapiens_hsa00600	1.43946497
22	Tight junction_Homo sapiens_hsa04530	1.40401894
23	Fatty acid degradation_Homo sapiens_hsa00071	1.33462641
24	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.24645658
25	Peroxisome_Homo sapiens_hsa04146	1.19388206
26	Salivary secretion_Homo sapiens_hsa04970	0.99779905
27	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.99198546
28	Notch signaling pathway_Homo sapiens_hsa04330	0.97878849
29	Circadian rhythm_Homo sapiens_hsa04710	0.96868398
30	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.96020196
31	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.93716210
32	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.85930375
33	Nicotine addiction_Homo sapiens_hsa05033	0.83802658
34	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.78257180
35	Phototransduction_Homo sapiens_hsa04744	0.77984292
36	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.77231036
37	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.75131682
38	Taste transduction_Homo sapiens_hsa04742	0.74675295
39	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.72102619
40	Olfactory transduction_Homo sapiens_hsa04740	0.71642705
41	Cocaine addiction_Homo sapiens_hsa05030	0.70018479
42	Collecting duct acid secretion_Homo sapiens_hsa04966	0.69471501
43	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.67056245
44	Choline metabolism in cancer_Homo sapiens_hsa05231	0.64922452
45	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.64094558
46	Basal cell carcinoma_Homo sapiens_hsa05217	0.63930952
47	Butanoate metabolism_Homo sapiens_hsa00650	0.62168259
48	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.58395602
49	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.58335996
50	Amphetamine addiction_Homo sapiens_hsa05031	0.56370193
51	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.54051989
52	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.51407971
53	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.50595124
54	PPAR signaling pathway_Homo sapiens_hsa03320	0.47835006
55	Serotonergic synapse_Homo sapiens_hsa04726	0.47561938
56	cAMP signaling pathway_Homo sapiens_hsa04024	0.46980677
57	Arginine and proline metabolism_Homo sapiens_hsa00330	0.45930112
58	Adherens junction_Homo sapiens_hsa04520	0.45549517
59	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.43866964
60	Axon guidance_Homo sapiens_hsa04360	0.43162165
61	Steroid biosynthesis_Homo sapiens_hsa00100	0.42699477
62	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.40424780
63	Tryptophan metabolism_Homo sapiens_hsa00380	0.39515770
64	Hepatitis C_Homo sapiens_hsa05160	0.39407558
65	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.37825237
66	Hippo signaling pathway_Homo sapiens_hsa04390	0.37789502
67	Metabolic pathways_Homo sapiens_hsa01100	0.36919151
68	Complement and coagulation cascades_Homo sapiens_hsa04610	0.35888813
69	Cardiac muscle contraction_Homo sapiens_hsa04260	0.34739127
70	Nitrogen metabolism_Homo sapiens_hsa00910	0.34375140
71	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.34232423
72	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.33904351
73	Regulation of autophagy_Homo sapiens_hsa04140	0.30392850
74	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.28668641
75	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.28331750
76	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.25726150
77	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.25455436
78	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.25312976
79	Calcium signaling pathway_Homo sapiens_hsa04020	0.25213307
80	Insulin secretion_Homo sapiens_hsa04911	0.24433573
81	Folate biosynthesis_Homo sapiens_hsa00790	0.21101478
82	Glycerolipid metabolism_Homo sapiens_hsa00561	0.20935045
83	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.20380977
84	Melanogenesis_Homo sapiens_hsa04916	0.20310394
85	Lysosome_Homo sapiens_hsa04142	0.19688219
86	Glutamatergic synapse_Homo sapiens_hsa04724	0.19626266
87	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.18956217
88	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.17251962
89	Bile secretion_Homo sapiens_hsa04976	0.16795897
90	Pancreatic secretion_Homo sapiens_hsa04972	0.16630500
91	Insulin resistance_Homo sapiens_hsa04931	0.14427868
92	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.13619988
93	Wnt signaling pathway_Homo sapiens_hsa04310	0.13463897
94	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.12987694
95	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.12724432
96	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.12113049
97	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.11388918
98	Gastric acid secretion_Homo sapiens_hsa04971	0.10500118
99	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.10139201
100	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.09238741

DNAI1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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