DNAI2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the dynein intermediate chain family, and is part of the dynein complex of respiratory cilia and sperm flagella. Mutations in this gene are associated with primary ciliary dyskinesia type 9. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1left/right pattern formation (GO:0060972)9.24685648
2regulation of cilium movement (GO:0003352)8.01361805
3primary alcohol catabolic process (GO:0034310)7.73204580
4left/right axis specification (GO:0070986)7.03463814
5ventricular system development (GO:0021591)6.89310504
6vitamin transmembrane transport (GO:0035461)6.84752916
7ethanol metabolic process (GO:0006067)6.41285526
8microtubule bundle formation (GO:0001578)6.40680201
9diterpenoid biosynthetic process (GO:0016102)6.24739990
10intraciliary transport (GO:0042073)6.13209398
11* cilium organization (GO:0044782)5.63839593
12tolerance induction (GO:0002507)5.60545187
13centriole assembly (GO:0098534)5.45017878
14* cilium assembly (GO:0042384)5.44252478
15pyrimidine-containing compound transmembrane transport (GO:0072531)5.35245885
16response to xenobiotic stimulus (GO:0009410)5.21072649
17one-carbon compound transport (GO:0019755)5.10826260
18negative regulation of immunoglobulin mediated immune response (GO:0002890)5.10811288
19negative regulation of B cell mediated immunity (GO:0002713)5.10811288
20lung epithelium development (GO:0060428)4.98127074
21regulation of interleukin-5 production (GO:0032674)4.82243016
22ethanol oxidation (GO:0006069)4.80714022
23negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)4.80521904
24regulation of tolerance induction (GO:0002643)4.73684654
25protein localization to cilium (GO:0061512)4.69942439
26establishment of apical/basal cell polarity (GO:0035089)4.66759378
27negative regulation of T cell differentiation in thymus (GO:0033085)4.63286125
28microtubule-based movement (GO:0007018)4.63104863
29regulation of microtubule-based movement (GO:0060632)4.62534492
30glomerular epithelial cell development (GO:0072310)4.61730675
31negative regulation of humoral immune response (GO:0002921)4.54276386
32sperm capacitation (GO:0048240)4.51618294
33regulation of germinal center formation (GO:0002634)4.42963506
34regulation of interleukin-13 production (GO:0032656)4.42073008
35positive regulation of tolerance induction (GO:0002645)4.39134618
36* cellular component assembly involved in morphogenesis (GO:0010927)4.32030129
37terpenoid biosynthetic process (GO:0016114)4.31926713
38retinoic acid metabolic process (GO:0042573)4.18357398
39cilium morphogenesis (GO:0060271)4.07174203
40establishment of monopolar cell polarity (GO:0061162)4.02427558
41establishment or maintenance of monopolar cell polarity (GO:0061339)4.02427558
42* cell projection assembly (GO:0030031)4.01422277
43nucleoside diphosphate phosphorylation (GO:0006165)3.86449833
44cytoplasmic microtubule organization (GO:0031122)3.71427904
45microtubule depolymerization (GO:0007019)3.66335710
46negative regulation of inclusion body assembly (GO:0090084)3.64244037
47exogenous drug catabolic process (GO:0042738)3.59015469
48lateral ventricle development (GO:0021670)3.46392091
49microtubule polymerization or depolymerization (GO:0031109)3.42646341
50primary alcohol metabolic process (GO:0034308)3.37812927
51hydrogen peroxide biosynthetic process (GO:0050665)3.30577846
52O-glycan processing (GO:0016266)3.26432843
53establishment of planar polarity (GO:0001736)3.25050987
54establishment of tissue polarity (GO:0007164)3.25050987
55retinol metabolic process (GO:0042572)3.24771598
56regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.10492259
57centriole replication (GO:0007099)3.08072169
58positive regulation of smoothened signaling pathway (GO:0045880)3.03458040
59glutathione derivative biosynthetic process (GO:1901687)3.00275374
60glutathione derivative metabolic process (GO:1901685)3.00275374
61axonemal dynein complex assembly (GO:0070286)22.1059426
62aldehyde catabolic process (GO:0046185)2.96700904
63reactive oxygen species biosynthetic process (GO:1903409)2.95037170
64regulation of microtubule depolymerization (GO:0031114)2.92774297
65multicellular organismal water homeostasis (GO:0050891)2.86508846
66carnitine metabolic process (GO:0009437)2.84667354
67determination of left/right symmetry (GO:0007368)2.82744662
68phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.80719237
69sperm motility (GO:0030317)2.79476289
70drug catabolic process (GO:0042737)2.76212001
71progesterone metabolic process (GO:0042448)2.74213754
72hypotonic response (GO:0006971)2.72532117
73determination of bilateral symmetry (GO:0009855)2.71965009
74microtubule-based process (GO:0007017)2.71748586
75hydrogen peroxide catabolic process (GO:0042744)2.69140213
76lateral sprouting from an epithelium (GO:0060601)2.67324340
77specification of symmetry (GO:0009799)2.65687986
78apical protein localization (GO:0045176)2.63667916
79phosphatidylcholine biosynthetic process (GO:0006656)2.63229516
80smoothened signaling pathway (GO:0007224)2.58025199
81lipoxygenase pathway (GO:0019372)2.57334483
82excretion (GO:0007588)2.56695357
83regulation of autophagic vacuole assembly (GO:2000785)2.56297463
84intra-S DNA damage checkpoint (GO:0031573)2.55583916
85negative regulation of adaptive immune response (GO:0002820)2.54212873
86regulation of response to osmotic stress (GO:0047484)2.52613052
87CDP-diacylglycerol biosynthetic process (GO:0016024)2.51775392
88calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.50009330
89regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.48063707
90regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.44220583
91oligosaccharide biosynthetic process (GO:0009312)2.43983014
92regulation of apoptotic cell clearance (GO:2000425)2.43602741
93retinal rod cell development (GO:0046548)2.43468639
94water homeostasis (GO:0030104)2.42600347
95cilium or flagellum-dependent cell motility (GO:0001539)18.3800023
96cilium movement (GO:0003341)15.8725042
97motile cilium assembly (GO:0044458)15.2651375
98epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)14.3917372
99epithelial cilium movement (GO:0003351)13.5521576
100axoneme assembly (GO:0035082)10.1984755

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat6.06761734
2DROSHA_22980978_ChIP-Seq_HELA_Human3.52368013
3FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human3.47768197
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.40799424
5TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.27801073
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.11650450
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.08579453
8PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.92006643
9TRIM28_21343339_ChIP-Seq_HEK293_Human2.66837008
10ESR1_20079471_ChIP-ChIP_T-47D_Human2.21989820
11RUNX1_27514584_Chip-Seq_MCF-7_Human1.96907852
12SOX2_27498859_Chip-Seq_STOMACH_Mouse1.91602026
13ESR1_21235772_ChIP-Seq_MCF-7_Human1.88324876
14TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.86731515
15SMC4_20622854_ChIP-Seq_HELA_Human1.85413038
16ESR2_21235772_ChIP-Seq_MCF-7_Human1.84438095
17AHR_22903824_ChIP-Seq_MCF-7_Human1.82537193
18FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.79707855
19STAT1_20625510_ChIP-Seq_HELA_Human1.79039467
20PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.60713882
21AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.58881022
22ELF1_20517297_ChIP-Seq_JURKAT_Human1.53730367
23PIAS1_25552417_ChIP-Seq_VCAP_Human1.53258138
24SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.53051336
25ARNT_22903824_ChIP-Seq_MCF-7_Human1.51501674
26P63_26484246_Chip-Seq_KERATINOCYTES_Human1.51176276
27TP63_22573176_ChIP-Seq_HFKS_Human1.50505587
28KLF5_25053715_ChIP-Seq_YYC3_Human1.50450523
29FOXM1_26456572_ChIP-Seq_MCF-7_Human1.48899281
30* TP63_23658742_ChIP-Seq_EP156T_Human1.47888644
31CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.45906134
32CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.45706805
33RAD21_21589869_ChIP-Seq_MESCs_Mouse1.45241966
34ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.42937462
35TDRD3_21172665_ChIP-Seq_MCF-7_Human1.42184701
36KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.42010226
37ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.39099956
38SOX2_20726797_ChIP-Seq_SW620_Human1.38476072
39CTNNB1_20460455_ChIP-Seq_HCT116_Human1.37743559
40SOX9_24532713_ChIP-Seq_HFSC_Mouse1.37583733
41VDR_22108803_ChIP-Seq_LS180_Human1.35504052
42SMRT_27268052_Chip-Seq_Bcells_Human1.33479332
43ETV1_20927104_ChIP-Seq_GIST48_Human1.33070166
44ZNF217_24962896_ChIP-Seq_MCF-7_Human1.32697681
45STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.28786475
46FOXA1_25552417_ChIP-Seq_VCAP_Human1.27307261
47* GATA1_19941826_ChIP-Seq_K562_Human1.25850853
48NR3C1_21868756_ChIP-Seq_MCF10A_Human1.24774716
49P68_20966046_ChIP-Seq_HELA_Human1.23366318
50CTCF_20526341_ChIP-Seq_ESCs_Human1.21973205
51TP53_18474530_ChIP-ChIP_U2OS_Human1.21749808
52CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.21429788
53HNFA_21074721_ChIP-Seq_CACO-2_Human1.20509956
54PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.19787035
55FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.18771021
56PHF8_20622853_ChIP-Seq_HELA_Human1.18244796
57CDX2_20551321_ChIP-Seq_CACO-2_Human1.16282635
58PHF8_20622854_ChIP-Seq_HELA_Human1.13251021
59CREB1_26743006_Chip-Seq_LNCaP_Human1.12297964
60YY1_22570637_ChIP-Seq_MALME-3M_Human1.10736515
61RBPJ_21746931_ChIP-Seq_IB4_Human1.08869437
62CTCF_27219007_Chip-Seq_Bcells_Human1.07403471
63TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.07049232
64CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.06470637
65P300_27268052_Chip-Seq_Bcells_Human1.06061095
66GATA3_24758297_ChIP-Seq_MCF-7_Human1.03516668
67FOXO3_23340844_ChIP-Seq_DLD1_Human1.03242315
68SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.02458125
69GATA6_21074721_ChIP-Seq_CACO-2_Human1.02002237
70SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.01915534
71RACK7_27058665_Chip-Seq_MCF-7_Human1.01678500
72CBX2_22325352_ChIP-Seq_293T-Rex_Human1.00178617
73GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.99113839
74CEBPB_22108803_ChIP-Seq_LS180_Human0.98890778
75FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.98223138
76* GATA4_25053715_ChIP-Seq_YYC3_Human0.97659069
77WDR5_24793694_ChIP-Seq_LNCAP_Human0.95844701
78FOXA2_19822575_ChIP-Seq_HepG2_Human0.95779014
79NFYA_21822215_ChIP-Seq_K562_Human0.95397109
80LXR_22292898_ChIP-Seq_THP-1_Human0.93820602
81TOP2B_26459242_ChIP-Seq_MCF-7_Human0.93542482
82CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93213472
83KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.93076305
84FLI1_21867929_ChIP-Seq_CD8_Mouse0.92916855
85PPAR_26484153_Chip-Seq_NCI-H1993_Human0.92141528
86RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.91841092
87SMAD3_21741376_ChIP-Seq_HESCs_Human0.90833323
88SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.90811932
89TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.90289401
90STAT6_21828071_ChIP-Seq_BEAS2B_Human0.89933112
91VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.89781483
92* GATA2_19941826_ChIP-Seq_K562_Human0.89285470
93CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.85816798
94NFYB_21822215_ChIP-Seq_K562_Human0.85453064
95SRY_22984422_ChIP-ChIP_TESTIS_Rat0.85220787
96E2F1_20622854_ChIP-Seq_HELA_Human0.84528208
97BCOR_27268052_Chip-Seq_Bcells_Human0.83441636
98OCT4_20526341_ChIP-Seq_ESCs_Human0.82625783
99RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.82514893
100TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.81981932

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008875_abnormal_xenobiotic_pharmacok7.10108610
2MP0002653_abnormal_ependyma_morphology6.69390477
3MP0002132_abnormal_respiratory_system5.65588854
4MP0001984_abnormal_olfaction4.11111146
5MP0004043_abnormal_pH_regulation4.01086258
6MP0009780_abnormal_chondrocyte_physiolo3.82729074
7MP0002277_abnormal_respiratory_mucosa3.76138724
8MP0005623_abnormal_meninges_morphology3.68611682
9MP0004133_heterotaxia3.49571783
10MP0008789_abnormal_olfactory_epithelium3.26623633
11MP0000566_synostosis2.37761597
12MP0005083_abnormal_biliary_tract2.21119251
13MP0005394_taste/olfaction_phenotype2.15496805
14MP0005499_abnormal_olfactory_system2.15496805
15MP0000383_abnormal_hair_follicle2.13439690
16MP0004019_abnormal_vitamin_homeostasis2.08135765
17MP0005377_hearing/vestibular/ear_phenot1.99413200
18MP0003878_abnormal_ear_physiology1.99413200
19MP0002168_other_aberrant_phenotype1.97879592
20MP0003656_abnormal_erythrocyte_physiolo1.97449652
21MP0002282_abnormal_trachea_morphology1.96709498
22MP0010678_abnormal_skin_adnexa1.89431281
23MP0002735_abnormal_chemical_nociception1.84807249
24MP0002160_abnormal_reproductive_system1.79361408
25MP0001765_abnormal_ion_homeostasis1.75972800
26MP0000678_abnormal_parathyroid_gland1.58953447
27MP0000465_gastrointestinal_hemorrhage1.50569071
28MP0002909_abnormal_adrenal_gland1.48026491
29MP0001346_abnormal_lacrimal_gland1.37103652
30MP0002734_abnormal_mechanical_nocicepti1.35135110
31MP0010234_abnormal_vibrissa_follicle1.34634340
32MP0010155_abnormal_intestine_physiology1.33614655
33MP0005165_increased_susceptibility_to1.31134633
34MP0002249_abnormal_larynx_morphology1.29923048
35MP0005395_other_phenotype1.25608695
36MP0005248_abnormal_Harderian_gland1.21592551
37MP0005636_abnormal_mineral_homeostasis1.19806943
38MP0003303_peritoneal_inflammation1.15559763
39MP0004264_abnormal_extraembryonic_tissu1.05681294
40MP0005503_abnormal_tendon_morphology1.02634558
41MP0002876_abnormal_thyroid_physiology1.01944933
42MP0002405_respiratory_system_inflammati1.01512450
43MP0009379_abnormal_foot_pigmentation0.98128863
44MP0002233_abnormal_nose_morphology0.97023439
45MP0006082_CNS_inflammation0.92151898
46MP0009765_abnormal_xenobiotic_induced0.91325692
47MP0002136_abnormal_kidney_physiology0.90604000
48MP0009643_abnormal_urine_homeostasis0.90489279
49MP0001849_ear_inflammation0.90181795
50MP0002638_abnormal_pupillary_reflex0.87811924
51MP0001790_abnormal_immune_system0.87137119
52MP0005387_immune_system_phenotype0.87137119
53MP0000681_abnormal_thyroid_gland0.87057742
54MP0005310_abnormal_salivary_gland0.86106893
55MP0005164_abnormal_response_to0.83153316
56MP0010030_abnormal_orbit_morphology0.82893911
57MP0003136_yellow_coat_color0.82836758
58MP0005389_reproductive_system_phenotype0.82612349
59MP0004883_abnormal_blood_vessel0.79757008
60MP0005408_hypopigmentation0.78029190
61MP0001929_abnormal_gametogenesis0.77245218
62MP0005365_abnormal_bile_salt0.75894896
63MP0009763_increased_sensitivity_to0.75668980
64MP0003698_abnormal_male_reproductive0.75218673
65MP0003453_abnormal_keratinocyte_physiol0.74870803
66MP0001485_abnormal_pinna_reflex0.69370682
67MP0000858_altered_metastatic_potential0.67848299
68MP0005220_abnormal_exocrine_pancreas0.65820389
69MP0003075_altered_response_to0.63784988
70MP0009046_muscle_twitch0.60757187
71MP0005085_abnormal_gallbladder_physiolo0.60010664
72MP0002098_abnormal_vibrissa_morphology0.58267887
73MP0002139_abnormal_hepatobiliary_system0.58172338
74MP0003866_abnormal_defecation0.56982216
75MP0001663_abnormal_digestive_system0.55662025
76MP0001324_abnormal_eye_pigmentation0.54665327
77MP0003950_abnormal_plasma_membrane0.53292323
78MP0000467_abnormal_esophagus_morphology0.53271627
79MP0001970_abnormal_pain_threshold0.50204565
80MP0005388_respiratory_system_phenotype0.49837400
81MP0002133_abnormal_respiratory_system0.49837400
82MP0001270_distended_abdomen0.49667370
83MP0001502_abnormal_circadian_rhythm0.46932645
84MP0005166_decreased_susceptibility_to0.45558764
85MP0009703_decreased_birth_body0.44399338
86MP0000026_abnormal_inner_ear0.43835769
87MP0008961_abnormal_basal_metabolism0.42152266
88MP0001293_anophthalmia0.42092451
89MP0002116_abnormal_craniofacial_bone0.41971686
90MP0008872_abnormal_physiological_respon0.41475435
91MP0002928_abnormal_bile_duct0.40077562
92MP0002135_abnormal_kidney_morphology0.39717353
93MP0002896_abnormal_bone_mineralization0.39693477
94MP0006036_abnormal_mitochondrial_physio0.39409962
95MP0001664_abnormal_digestion0.38858102
96MP0008873_increased_physiological_sensi0.38851582
97MP0005253_abnormal_eye_physiology0.38381892
98MP0002796_impaired_skin_barrier0.36110942
99MP0001944_abnormal_pancreas_morphology0.36023942
100MP0003638_abnormal_response/metabolism_0.35619978

Predicted human phenotypes

RankGene SetZ-score
1* Rhinitis (HP:0012384)9.65389627
2Chronic bronchitis (HP:0004469)8.04815566
3* Bronchiectasis (HP:0002110)7.27361900
4Nasal polyposis (HP:0100582)7.06602131
5Abnormality of the nasal mucosa (HP:0000433)5.88721121
6Bronchitis (HP:0012387)4.53438871
7Chronic sinusitis (HP:0011109)4.21407259
8* Infertility (HP:0000789)3.84560906
9Occipital encephalocele (HP:0002085)3.61162272
10* Recurrent sinusitis (HP:0011108)3.61074947
11* Recurrent otitis media (HP:0000403)3.59618414
12Pancreatic fibrosis (HP:0100732)3.33474786
13True hermaphroditism (HP:0010459)3.29307289
14Chronic otitis media (HP:0000389)3.19985476
15Atelectasis (HP:0100750)3.11252615
16Hyperactive renin-angiotensin system (HP:0000841)3.09222203
17Cystic liver disease (HP:0006706)2.75700506
18Abnormality of midbrain morphology (HP:0002418)2.72155837
19Molar tooth sign on MRI (HP:0002419)2.72155837
20Pancreatic cysts (HP:0001737)2.67048046
21Nephronophthisis (HP:0000090)2.57600750
22Postaxial foot polydactyly (HP:0001830)2.39243934
23Chronic hepatic failure (HP:0100626)2.38914020
24* Male infertility (HP:0003251)2.17382721
25Recurrent bronchitis (HP:0002837)2.11867393
26Bell-shaped thorax (HP:0001591)2.08261528
27Tubulointerstitial nephritis (HP:0001970)2.01623459
28Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.8009198
29Abnormal respiratory motile cilium morphology (HP:0005938)11.5067214
30Abnormal respiratory epithelium morphology (HP:0012253)11.5067214
31Abnormal respiratory motile cilium physiology (HP:0012261)11.2693168
32Absent/shortened dynein arms (HP:0200106)11.2413599
33Dynein arm defect of respiratory motile cilia (HP:0012255)11.2413599
34Abnormal ciliary motility (HP:0012262)11.0783780
35Congenital hepatic fibrosis (HP:0002612)1.99280556
36Abnormality of the renal medulla (HP:0100957)1.97806620
37Absent frontal sinuses (HP:0002688)1.95029454
38Anencephaly (HP:0002323)1.91409249
39Renal salt wasting (HP:0000127)1.90120412
40Aplasia/Hypoplasia of the tongue (HP:0010295)1.85393998
41Asplenia (HP:0001746)1.84403194
42Decreased circulating renin level (HP:0003351)1.84313355
43Aplasia/Hypoplasia of the spleen (HP:0010451)1.82814766
44Male pseudohermaphroditism (HP:0000037)1.82804404
45Medial flaring of the eyebrow (HP:0010747)1.71386014
46Nephropathy (HP:0000112)1.67851548
47Hyperkalemia (HP:0002153)1.64887333
48Furrowed tongue (HP:0000221)1.63236634
49Congenital primary aphakia (HP:0007707)1.61018695
50Sclerocornea (HP:0000647)1.60230750
51Oculomotor apraxia (HP:0000657)1.59780753
52Tubular atrophy (HP:0000092)1.59733388
53Gait imbalance (HP:0002141)1.57593301
54Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.53021563
55Hyperaldosteronism (HP:0000859)1.52811545
56Nephrogenic diabetes insipidus (HP:0009806)1.44633024
57Postaxial hand polydactyly (HP:0001162)1.44158668
58Absent rod-and cone-mediated responses on ERG (HP:0007688)1.39562113
59Abnormality of renin-angiotensin system (HP:0000847)1.39064131
60Abnormality of chloride homeostasis (HP:0011422)1.37498337
61Hypokalemic alkalosis (HP:0001949)1.30011895
62Abnormality of the distal phalanges of the toes (HP:0010182)1.27496505
63Hyponatremia (HP:0002902)1.27439223
64Short thorax (HP:0010306)1.25617240
65Hand muscle atrophy (HP:0009130)1.25210269
66Median cleft lip (HP:0000161)1.23095821
67Preaxial hand polydactyly (HP:0001177)1.22105950
68Abnormality of the frontal sinuses (HP:0002687)1.21309876
69Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.21086588
70Glucose intolerance (HP:0000833)1.20425392
71Cone-rod dystrophy (HP:0000548)1.14204283
72Fetal akinesia sequence (HP:0001989)1.13950162
73Decreased central vision (HP:0007663)1.13271910
74Abnormality of the dental root (HP:0006486)1.12904053
75Taurodontia (HP:0000679)1.12904053
76Abnormality of permanent molar morphology (HP:0011071)1.12904053
77Obstructive sleep apnea (HP:0002870)1.11639751
78Bifid scrotum (HP:0000048)1.10905042
79Short nail (HP:0001799)1.10383594
80Tubulointerstitial abnormality (HP:0001969)1.10373503
81Stage 5 chronic kidney disease (HP:0003774)1.09712521
82Abnormality of monocarboxylic acid metabolism (HP:0010996)1.08283221
83Poor coordination (HP:0002370)1.07687092
84Short femoral neck (HP:0100864)1.07573628
85Vaginal atresia (HP:0000148)1.05470189
86Muscle fiber splitting (HP:0003555)1.05195865
87Abnormal drinking behavior (HP:0030082)1.05115169
88Polydipsia (HP:0001959)1.05115169
89Genital tract atresia (HP:0001827)1.04122893
90Abnormality of molar morphology (HP:0011070)1.03385048
91Abnormality of molar (HP:0011077)1.03385048
92Aplasia of the musculature (HP:0100854)1.00329740
93Abnormality of the dental pulp (HP:0006479)0.99756129
94Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)0.99618360
95Flat acetabular roof (HP:0003180)0.97953629
96Spinal muscular atrophy (HP:0007269)0.97373010
97Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)0.95919102
98Abnormality of sodium homeostasis (HP:0010931)0.95722088
99Popliteal pterygium (HP:0009756)0.94753344
100Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)0.94682919

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST45.60266735
2EPHA24.94600646
3SMG12.24115698
4MAPKAPK32.22516110
5NME12.20514275
6MAP3K22.16121587
7MAPK1511.8752284
8STK241.91664083
9EEF2K1.72200088
10CSK1.69234478
11MAP3K31.65808825
12TTK1.61962349
13BCR1.39699438
14PTK2B1.37908133
15EPHB11.34996707
16STK101.26615814
17PNCK1.20348648
18TRIM281.19827526
19RIPK41.17933246
20LRRK21.14581211
21NEK61.14283088
22TLK11.13708678
23MARK21.10847585
24TBK11.06087444
25TRPM71.04506371
26EPHA31.01033435
27MST1R1.00399393
28PRKCI0.93726165
29GRK60.92202976
30MAP3K70.90489164
31TESK10.88594292
32CAMKK10.87058182
33TAOK10.84938852
34STK380.83110568
35ERBB30.82473826
36TRIB30.73602669
37ICK0.68451680
38FER0.67794529
39ERBB20.65696161
40BRSK20.62114733
41RIPK10.59204548
42HIPK20.57788553
43DYRK1B0.53448711
44CAMK2G0.50394168
45MAP3K120.50282378
46PRKCD0.48936743
47PRKCQ0.46197136
48STK160.42766371
49TYK20.40386585
50PDPK10.40066725
51NLK0.37461078
52SGK10.36690082
53IRAK10.36427756
54MATK0.36348548
55AURKA0.36061319
56RPS6KB20.35028901
57CDK60.34014143
58PRKAA20.31515760
59ZAP700.31512283
60CDC42BPA0.28988215
61PRKD20.28940431
62MAP3K40.28603437
63BMPR20.24168061
64MAP2K20.23234931
65FGFR30.22867345
66AKT20.22032153
67PRKACA0.21795151
68ABL10.21051965
69PRKCA0.20524169
70GRK10.20400172
71PAK10.20323026
72ROCK20.19446360
73ADRBK10.18888219
74CAMKK20.18851825
75PTK60.18333866
76PASK0.17921248
77DYRK1A0.17900340
78PAK40.17521266
79FYN0.17426404
80SRC0.16987735
81EGFR0.16931590
82PLK10.14674612
83CHUK0.14514147
84PRKCZ0.14284951
85PDK10.14267263
86MAP2K40.13877966
87IKBKE0.13538608
88RPS6KA20.12726327
89ROCK10.12590193
90MAPKAPK50.11427316
91PBK0.11327786
92MAPK100.10437549
93STK38L0.10436940
94PRKCH0.10374200
95LMTK20.09696031
96MYLK0.09588478
97MAP2K70.09447347
98EPHA40.06812912
99CAMK2A0.06761641
100IGF1R0.06742877

Predicted pathways (KEGG)

RankGene SetZ-score
1Histidine metabolism_Homo sapiens_hsa003405.73585550
2Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009805.59063566
3Phenylalanine metabolism_Homo sapiens_hsa003605.18383456
4Chemical carcinogenesis_Homo sapiens_hsa052044.52648475
5Drug metabolism - cytochrome P450_Homo sapiens_hsa009824.23939243
6Tyrosine metabolism_Homo sapiens_hsa003503.90076652
7beta-Alanine metabolism_Homo sapiens_hsa004102.91681425
8Glutathione metabolism_Homo sapiens_hsa004802.48247426
9Caffeine metabolism_Homo sapiens_hsa002322.47519804
10Huntingtons disease_Homo sapiens_hsa050162.29234484
11Retinol metabolism_Homo sapiens_hsa008302.29020002
12Linoleic acid metabolism_Homo sapiens_hsa005911.72085932
13Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.68619070
14Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.67305604
15Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.64196769
16Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.63296778
17Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.48202605
18Sphingolipid metabolism_Homo sapiens_hsa006001.46973790
19Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.44724988
20Steroid hormone biosynthesis_Homo sapiens_hsa001401.41240126
21ABC transporters_Homo sapiens_hsa020101.32838989
22Tight junction_Homo sapiens_hsa045301.32234678
23Fatty acid degradation_Homo sapiens_hsa000711.21759279
24Peroxisome_Homo sapiens_hsa041461.14946452
25Asthma_Homo sapiens_hsa053101.08412806
26Arachidonic acid metabolism_Homo sapiens_hsa005901.06273953
27Starch and sucrose metabolism_Homo sapiens_hsa005001.04923010
28Salivary secretion_Homo sapiens_hsa049700.94640536
29Carbohydrate digestion and absorption_Homo sapiens_hsa049730.92189608
30Hepatitis C_Homo sapiens_hsa051600.86987581
31Hematopoietic cell lineage_Homo sapiens_hsa046400.83588130
32Leukocyte transendothelial migration_Homo sapiens_hsa046700.82455481
33Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.78571654
34Drug metabolism - other enzymes_Homo sapiens_hsa009830.75571750
35Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.73326414
36Glycerophospholipid metabolism_Homo sapiens_hsa005640.72120860
37Circadian rhythm_Homo sapiens_hsa047100.70045081
38Pentose and glucuronate interconversions_Homo sapiens_hsa000400.68727477
39Notch signaling pathway_Homo sapiens_hsa043300.67975685
40Choline metabolism in cancer_Homo sapiens_hsa052310.67090676
41Primary bile acid biosynthesis_Homo sapiens_hsa001200.57207021
42Olfactory transduction_Homo sapiens_hsa047400.56250393
43Taste transduction_Homo sapiens_hsa047420.54751956
44Adherens junction_Homo sapiens_hsa045200.51735238
45Allograft rejection_Homo sapiens_hsa053300.51568817
46Intestinal immune network for IgA production_Homo sapiens_hsa046720.49105557
47Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.48232564
48Autoimmune thyroid disease_Homo sapiens_hsa053200.47960934
49Complement and coagulation cascades_Homo sapiens_hsa046100.46937070
50Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.44705344
51Hedgehog signaling pathway_Homo sapiens_hsa043400.42812123
52Transcriptional misregulation in cancer_Homo sapiens_hsa052020.41531870
53Sphingolipid signaling pathway_Homo sapiens_hsa040710.40401525
54Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.40063095
55Lysosome_Homo sapiens_hsa041420.39255581
56Collecting duct acid secretion_Homo sapiens_hsa049660.38940886
57Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.38405296
58Type I diabetes mellitus_Homo sapiens_hsa049400.38236543
59Jak-STAT signaling pathway_Homo sapiens_hsa046300.36155513
60PPAR signaling pathway_Homo sapiens_hsa033200.34876447
61Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.31983433
62Pancreatic secretion_Homo sapiens_hsa049720.30574424
63Graft-versus-host disease_Homo sapiens_hsa053320.30008706
64Cocaine addiction_Homo sapiens_hsa050300.28343699
65Basal cell carcinoma_Homo sapiens_hsa052170.27757352
66RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.27248724
67Glycosaminoglycan degradation_Homo sapiens_hsa005310.27101235
68cAMP signaling pathway_Homo sapiens_hsa040240.26824972
69Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.26229191
70Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.26204681
71Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.25567647
72Metabolic pathways_Homo sapiens_hsa011000.25175928
73Insulin resistance_Homo sapiens_hsa049310.24148276
74Cyanoamino acid metabolism_Homo sapiens_hsa004600.23407919
75Amoebiasis_Homo sapiens_hsa051460.22640332
76Phototransduction_Homo sapiens_hsa047440.21198160
77Antigen processing and presentation_Homo sapiens_hsa046120.20675916
78Arginine and proline metabolism_Homo sapiens_hsa003300.20178150
79Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.18828885
80Vitamin digestion and absorption_Homo sapiens_hsa049770.16737905
81Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.15703589
82Phagosome_Homo sapiens_hsa041450.15298141
83Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.12413293
84Glycerolipid metabolism_Homo sapiens_hsa005610.11730795
85Dilated cardiomyopathy_Homo sapiens_hsa054140.11353518
86Amphetamine addiction_Homo sapiens_hsa050310.11096078
87Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.10903669
88Endocytosis_Homo sapiens_hsa041440.10762292
89Phosphatidylinositol signaling system_Homo sapiens_hsa040700.10611927
90Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.10012536
91Serotonergic synapse_Homo sapiens_hsa047260.09967812
92SNARE interactions in vesicular transport_Homo sapiens_hsa041300.09417427
93Nicotine addiction_Homo sapiens_hsa050330.09016086
94Hippo signaling pathway_Homo sapiens_hsa043900.08996184
95Calcium signaling pathway_Homo sapiens_hsa040200.08895338
96Bile secretion_Homo sapiens_hsa049760.08185053
97Staphylococcus aureus infection_Homo sapiens_hsa051500.07683901
98Ovarian steroidogenesis_Homo sapiens_hsa049130.06746536
99Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.06236837
100Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.05659942

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