DNAJA1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the DnaJ family of proteins, which act as heat shock protein 70 cochaperones. Heat shock proteins facilitate protein folding, trafficking, prevention of aggregation, and proteolytic degradation. Members of this family are characterized by a highly conserved N-terminal J domain, a glycine/phenylalanine-rich region, four CxxCxGxG zinc finger repeats, and a C-terminal substrate-binding domain. The J domain mediates the interaction with heat shock protein 70 to recruit substrates and regulate ATP hydrolysis activity. In humans, this gene has been implicated in positive regulation of virus replication through co-option by the influenza A virus. Several pseudogenes of this gene are found on other chromosomes. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1dopamine biosynthetic process (GO:0042416)4.47820492
2nucleotide transmembrane transport (GO:1901679)4.45566715
3response to insecticide (GO:0017085)4.33142160
4protein neddylation (GO:0045116)4.32111103
5cullin deneddylation (GO:0010388)4.21676051
6pyrimidine-containing compound transmembrane transport (GO:0072531)4.15881912
7establishment of integrated proviral latency (GO:0075713)4.15373928
8protein refolding (GO:0042026)4.06405103
9negative regulation of inclusion body assembly (GO:0090084)4.05042914
10microtubule depolymerization (GO:0007019)4.01208504
11CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.98030445
12interleukin-6-mediated signaling pathway (GO:0070102)3.95321927
13purine nucleobase biosynthetic process (GO:0009113)3.84252797
14ribosome assembly (GO:0042255)3.78957043
15protein deneddylation (GO:0000338)3.76623196
16proteasome assembly (GO:0043248)3.75320130
17regulation of transmission of nerve impulse (GO:0051969)3.72808188
187-methylguanosine mRNA capping (GO:0006370)3.72685321
19RNA capping (GO:0036260)3.64154912
207-methylguanosine RNA capping (GO:0009452)3.64154912
21chromatin remodeling at centromere (GO:0031055)3.64027788
22mitotic metaphase plate congression (GO:0007080)3.58017967
23CENP-A containing nucleosome assembly (GO:0034080)3.56432471
24chaperone-mediated protein transport (GO:0072321)3.56359874
25transcription elongation from RNA polymerase I promoter (GO:0006362)3.51756441
26establishment of viral latency (GO:0019043)3.47697805
27regulation of dopamine metabolic process (GO:0042053)3.42398578
28regulation of catecholamine metabolic process (GO:0042069)3.42398578
29establishment of protein localization to mitochondrial membrane (GO:0090151)3.41189279
30metaphase plate congression (GO:0051310)3.37594158
31cellular glucuronidation (GO:0052695)3.32173070
32regulation of mitochondrial translation (GO:0070129)3.28046995
33neuron cell-cell adhesion (GO:0007158)3.27981985
34regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.25568185
35glucuronate metabolic process (GO:0019585)3.23349187
36uronic acid metabolic process (GO:0006063)3.23349187
37protein-cofactor linkage (GO:0018065)3.22648563
38regulation of helicase activity (GO:0051095)3.22340798
39keratinocyte development (GO:0003334)3.20739138
40DNA double-strand break processing (GO:0000729)3.16338289
41termination of RNA polymerase I transcription (GO:0006363)3.14360656
42DNA ligation (GO:0006266)3.11444091
43guanosine-containing compound biosynthetic process (GO:1901070)3.11055965
44positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.10770286
45chaperone mediated protein folding requiring cofactor (GO:0051085)3.10257859
46histone exchange (GO:0043486)3.10106234
47regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.09547658
48regulation of mitotic spindle checkpoint (GO:1903504)3.09547658
49negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.08787034
50termination of RNA polymerase III transcription (GO:0006386)3.08019453
51transcription elongation from RNA polymerase III promoter (GO:0006385)3.08019453
52DNA catabolic process, exonucleolytic (GO:0000738)3.06484817
53signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.06461168
54intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.06461168
55ER overload response (GO:0006983)3.04535045
56pyrimidine nucleobase catabolic process (GO:0006208)3.04152735
57dopamine transport (GO:0015872)3.03797011
58negative regulation of DNA-dependent DNA replication (GO:2000104)3.03488769
59microtubule polymerization or depolymerization (GO:0031109)3.01644231
60signal transduction involved in cell cycle checkpoint (GO:0072395)3.01436698
61negative regulation of DNA recombination (GO:0045910)2.98211282
62histone H2A acetylation (GO:0043968)2.98187721
63signal transduction involved in DNA damage checkpoint (GO:0072422)2.97629863
64signal transduction involved in DNA integrity checkpoint (GO:0072401)2.97629863
65nucleobase biosynthetic process (GO:0046112)2.97354929
66regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.97102403
67negative regulation of dendrite morphogenesis (GO:0050774)2.94463973
68protein localization to kinetochore (GO:0034501)2.92493076
69regulation of cellular amino acid metabolic process (GO:0006521)2.91064708
70positive regulation of neurological system process (GO:0031646)2.90322459
71transcription initiation from RNA polymerase I promoter (GO:0006361)2.90256043
72positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.88850586
73anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.87946082
74transcription from RNA polymerase I promoter (GO:0006360)2.87536937
75DNA replication-independent nucleosome organization (GO:0034724)2.87132007
76DNA replication-independent nucleosome assembly (GO:0006336)2.87132007
77non-recombinational repair (GO:0000726)2.86938582
78double-strand break repair via nonhomologous end joining (GO:0006303)2.86938582
79GMP metabolic process (GO:0046037)2.86182151
80positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)2.86094235
81ribonucleoprotein complex disassembly (GO:0032988)2.84597702
82catecholamine biosynthetic process (GO:0042423)2.84011298
83catechol-containing compound biosynthetic process (GO:0009713)2.84011298
84spliceosomal snRNP assembly (GO:0000387)2.84009778
85exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.82310688
86nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.79355795
87DNA replication checkpoint (GO:0000076)2.79054777
88postreplication repair (GO:0006301)2.78819557
89attachment of spindle microtubules to kinetochore (GO:0008608)2.77850075
90response to nitrosative stress (GO:0051409)2.77447748
91spindle checkpoint (GO:0031577)2.76935678
92regulation of ligase activity (GO:0051340)2.76893706
93regulation of centriole replication (GO:0046599)2.76507493
94IMP biosynthetic process (GO:0006188)2.76168934
95mitotic spindle checkpoint (GO:0071174)2.74164072
96histone mRNA metabolic process (GO:0008334)2.73087413
97negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.72622446
98negative regulation of ligase activity (GO:0051352)2.72622446
99somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.72248549
100isotype switching (GO:0045190)2.72248549
101somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.72248549
102mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.72248419
103mitochondrial respiratory chain complex I assembly (GO:0032981)2.72248419
104NADH dehydrogenase complex assembly (GO:0010257)2.72248419
105resolution of meiotic recombination intermediates (GO:0000712)2.71958567
106protein complex biogenesis (GO:0070271)2.71849533
107tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.71352695
108RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.71352695
109startle response (GO:0001964)2.70719802
110positive regulation of mitochondrial fission (GO:0090141)2.70280420
111T cell lineage commitment (GO:0002360)2.70132630
112tRNA aminoacylation for protein translation (GO:0006418)2.69766782
113establishment of chromosome localization (GO:0051303)2.69148946
114peripheral nervous system neuron development (GO:0048935)2.68955285
115regulation of inclusion body assembly (GO:0090083)2.68954872
116amino acid activation (GO:0043038)2.68898717
117tRNA aminoacylation (GO:0043039)2.68898717
118positive regulation of protein homodimerization activity (GO:0090073)2.68835879
119protein K11-linked ubiquitination (GO:0070979)2.68690465
120transferrin transport (GO:0033572)2.68078490
121positive regulation of protein import into nucleus, translocation (GO:0033160)2.67958453
122negative regulation of neurotransmitter transport (GO:0051589)2.67693942
123positive regulation of ligase activity (GO:0051351)2.66883769
124transcription elongation from RNA polymerase II promoter (GO:0006368)2.66828937
125spermatid nucleus differentiation (GO:0007289)2.66492427
126mitotic sister chromatid segregation (GO:0000070)2.65592818
127mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.65002365
128rRNA modification (GO:0000154)2.62870810
129regulation of respiratory gaseous exchange (GO:0043576)2.62815975
130* DNA damage response, detection of DNA damage (GO:0042769)2.61721273
131presynaptic membrane assembly (GO:0097105)2.61104534
132maturation of 5.8S rRNA (GO:0000460)2.60892645
133regulation of cellular amine metabolic process (GO:0033238)2.60279956
134respiratory chain complex IV assembly (GO:0008535)2.60036643
135RNA-dependent DNA replication (GO:0006278)2.58417470
136regulation of synaptic vesicle exocytosis (GO:2000300)2.57730063
137* negative regulation of protein ubiquitination (GO:0031397)2.56865491
138cholesterol biosynthetic process (GO:0006695)2.56840859
139de novo protein folding (GO:0006458)2.55747323
140negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.55316589
141negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.55316589
142negative regulation of mitotic sister chromatid segregation (GO:0033048)2.55316589
143negative regulation of mitotic sister chromatid separation (GO:2000816)2.55316589
144negative regulation of sister chromatid segregation (GO:0033046)2.55316589
145replication fork processing (GO:0031297)2.54972190
146mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.53881249
147synapsis (GO:0007129)2.53041844
148de novo posttranslational protein folding (GO:0051084)2.52945895
149ferric iron transport (GO:0015682)2.51861203
150trivalent inorganic cation transport (GO:0072512)2.51861203
151regulation of meiosis I (GO:0060631)2.51540115
152organelle disassembly (GO:1903008)2.51226325
153response to amphetamine (GO:0001975)2.50749551
154DNA-templated transcription, elongation (GO:0006354)2.49297029
155glutamate secretion (GO:0014047)2.49240083
156viral protein processing (GO:0019082)2.49035906
157signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.46627923
158signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.46627923
159signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.46627923
160long-chain fatty acid biosynthetic process (GO:0042759)2.46028272
161regulation of ubiquitin-protein transferase activity (GO:0051438)2.45242382
162negative regulation of synaptic transmission, GABAergic (GO:0032229)2.44695782
163dopamine metabolic process (GO:0042417)2.44509274
164negative regulation of chemokine production (GO:0032682)2.44480715
165DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.44095377
166folic acid transport (GO:0015884)2.43906499

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human3.62114173
2TAF15_26573619_Chip-Seq_HEK293_Human3.29392443
3VDR_22108803_ChIP-Seq_LS180_Human3.25862950
4RBPJ_22232070_ChIP-Seq_NCS_Mouse3.06568970
5E2F4_17652178_ChIP-ChIP_JURKAT_Human2.98800097
6GBX2_23144817_ChIP-Seq_PC3_Human2.86655718
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.85209391
8SALL1_21062744_ChIP-ChIP_HESCs_Human2.83023193
9E2F7_22180533_ChIP-Seq_HELA_Human2.77150359
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.47521063
11POU3F2_20337985_ChIP-ChIP_501MEL_Human2.35217989
12GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.29488559
13NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.25111383
14ZFP57_27257070_Chip-Seq_ESCs_Mouse2.24967088
15FUS_26573619_Chip-Seq_HEK293_Human2.22395685
16BMI1_23680149_ChIP-Seq_NPCS_Mouse2.20046422
17HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.09742201
18HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.04197444
19NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.03937811
20CREB1_15753290_ChIP-ChIP_HEK293T_Human2.02543615
21FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.02534414
22GABP_17652178_ChIP-ChIP_JURKAT_Human2.02236397
23EST1_17652178_ChIP-ChIP_JURKAT_Human2.02077584
24IRF1_19129219_ChIP-ChIP_H3396_Human1.99945794
25* EWS_26573619_Chip-Seq_HEK293_Human1.96969387
26POU5F1_16153702_ChIP-ChIP_HESCs_Human1.95697926
27JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.91421572
28PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.91339618
29P300_19829295_ChIP-Seq_ESCs_Human1.90514879
30FLI1_27457419_Chip-Seq_LIVER_Mouse1.89923493
31FOXM1_23109430_ChIP-Seq_U2OS_Human1.84197730
32CTBP2_25329375_ChIP-Seq_LNCAP_Human1.82480201
33* DCP1A_22483619_ChIP-Seq_HELA_Human1.79078946
34CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.73898921
35RNF2_27304074_Chip-Seq_NSC_Mouse1.71184334
36OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.69877467
37ETS1_20019798_ChIP-Seq_JURKAT_Human1.64491574
38CTBP1_25329375_ChIP-Seq_LNCAP_Human1.61452329
39FOXP3_21729870_ChIP-Seq_TREG_Human1.61338200
40* TTF2_22483619_ChIP-Seq_HELA_Human1.61009541
41ZNF274_21170338_ChIP-Seq_K562_Hela1.58268354
42CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.56992147
43* GABP_19822575_ChIP-Seq_HepG2_Human1.54503964
44MYC_18940864_ChIP-ChIP_HL60_Human1.53517634
45MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.53002711
46MYCN_18555785_ChIP-Seq_MESCs_Mouse1.52240858
47AR_21909140_ChIP-Seq_LNCAP_Human1.50899150
48NOTCH1_21737748_ChIP-Seq_TLL_Human1.50895847
49PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.49674691
50ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.49456285
51TOP2B_26459242_ChIP-Seq_MCF-7_Human1.49361662
52MYC_18358816_ChIP-ChIP_MESCs_Mouse1.48180726
53ELK1_19687146_ChIP-ChIP_HELA_Human1.46561380
54SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.46546437
55MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.46336075
56* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.45699189
57* MYC_19079543_ChIP-ChIP_MESCs_Mouse1.45181288
58UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.44719223
59GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44565316
60SMAD_19615063_ChIP-ChIP_OVARY_Human1.44406569
61* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.43597519
62PCGF2_27294783_Chip-Seq_ESCs_Mouse1.43444945
63CBX2_27304074_Chip-Seq_ESCs_Mouse1.42347707
64* VDR_23849224_ChIP-Seq_CD4+_Human1.36202430
65SMAD3_21741376_ChIP-Seq_EPCs_Human1.35920662
66YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.34338749
67IGF1R_20145208_ChIP-Seq_DFB_Human1.33814488
68TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.32212531
69SOX2_16153702_ChIP-ChIP_HESCs_Human1.31747431
70PIAS1_25552417_ChIP-Seq_VCAP_Human1.30583079
71SMAD4_21799915_ChIP-Seq_A2780_Human1.29372909
72ER_23166858_ChIP-Seq_MCF-7_Human1.29208655
73CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.28514734
74XRN2_22483619_ChIP-Seq_HELA_Human1.28315583
75FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.28152231
76SRF_21415370_ChIP-Seq_HL-1_Mouse1.26705454
77EZH2_27304074_Chip-Seq_ESCs_Mouse1.26601444
78CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25804196
79* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.21789937
80PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.21459010
81* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.21261014
82JUN_21703547_ChIP-Seq_K562_Human1.20544111
83PADI4_21655091_ChIP-ChIP_MCF-7_Human1.18896684
84SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.15725827
85REST_21632747_ChIP-Seq_MESCs_Mouse1.15635346
86SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.14741364
87HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.13872511
88SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.13809530
89AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.13705016
90NANOG_16153702_ChIP-ChIP_HESCs_Human1.13471959
91E2F1_21310950_ChIP-Seq_MCF-7_Human1.13006011
92EED_16625203_ChIP-ChIP_MESCs_Mouse1.12897180
93* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.10517295
94HTT_18923047_ChIP-ChIP_STHdh_Human1.09349188
95TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.09285912
96RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.09163004
97SOX9_26525672_Chip-Seq_HEART_Mouse1.08929293
98NR3C1_23031785_ChIP-Seq_PC12_Mouse1.07561669
99NANOG_18555785_Chip-Seq_ESCs_Mouse1.07111704
100EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.06516629
101MYC_18555785_ChIP-Seq_MESCs_Mouse1.06281824
102* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.06209182
103POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.05815364
104AR_25329375_ChIP-Seq_VCAP_Human1.05498319
105* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.05467694
106SOX2_18555785_ChIP-Seq_MESCs_Mouse1.04852065
107MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.04679294
108ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.04330974
109FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.04030566
110TP63_19390658_ChIP-ChIP_HaCaT_Human1.03968600
111E2F1_18555785_Chip-Seq_ESCs_Mouse1.02689300
112THAP11_20581084_ChIP-Seq_MESCs_Mouse1.01058934
113CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.00747078
114YY1_21170310_ChIP-Seq_MESCs_Mouse0.99173695
115KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.99074537
116EZH2_22144423_ChIP-Seq_EOC_Human0.98720174
117MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.97959130
118SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.97459891
119SUZ12_18555785_Chip-Seq_ESCs_Mouse0.96215569
120POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.95537532
121NR3C1_21868756_ChIP-Seq_MCF10A_Human0.95234189
122P53_22387025_ChIP-Seq_ESCs_Mouse0.94633898
123ZFX_18555785_ChIP-Seq_MESCs_Mouse0.93858825
124DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.93688811
125* MYC_19030024_ChIP-ChIP_MESCs_Mouse0.93665041
126WT1_19549856_ChIP-ChIP_CCG9911_Human0.93644183
127PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.93628881
128NFE2_27457419_Chip-Seq_LIVER_Mouse0.93300821
129STAT3_23295773_ChIP-Seq_U87_Human0.93151124
130ELK1_22589737_ChIP-Seq_MCF10A_Human0.92797045
131EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.92387228
132GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.91726407
133CBP_20019798_ChIP-Seq_JUKART_Human0.89037143
134IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.89037143
135TP53_22573176_ChIP-Seq_HFKS_Human0.88804142
136ELF1_17652178_ChIP-ChIP_JURKAT_Human0.88688532
137CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.85492125
138SUZ12_27294783_Chip-Seq_NPCs_Mouse0.85325283
139REST_19997604_ChIP-ChIP_NEURONS_Mouse0.83626088

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern3.76842564
2MP0001905_abnormal_dopamine_level3.03200997
3MP0008057_abnormal_DNA_replication2.88404068
4MP0001529_abnormal_vocalization2.58993530
5MP0001501_abnormal_sleep_pattern2.48727372
6MP0006292_abnormal_olfactory_placode2.43938873
7MP0001188_hyperpigmentation2.43667246
8MP0002734_abnormal_mechanical_nocicepti2.42483946
9MP0005646_abnormal_pituitary_gland2.37021087
10MP0008789_abnormal_olfactory_epithelium2.34644258
11MP0002102_abnormal_ear_morphology2.33732304
12MP0006276_abnormal_autonomic_nervous2.21852879
13MP0003122_maternal_imprinting2.21468151
14MP0008877_abnormal_DNA_methylation2.14847079
15MP0005394_taste/olfaction_phenotype2.12797426
16MP0005499_abnormal_olfactory_system2.12797426
17MP0002736_abnormal_nociception_after2.09613606
18MP0009745_abnormal_behavioral_response2.08160893
19MP0004270_analgesia2.03523537
20MP0003787_abnormal_imprinting2.01542714
21MP0001984_abnormal_olfaction2.00528300
22MP0001968_abnormal_touch/_nociception1.89318824
23MP0002735_abnormal_chemical_nociception1.87879445
24MP0006072_abnormal_retinal_apoptosis1.87438470
25MP0003786_premature_aging1.84809219
26MP0003121_genomic_imprinting1.80615106
27MP0003693_abnormal_embryo_hatching1.75648899
28MP0002132_abnormal_respiratory_system1.74543429
29MP0003635_abnormal_synaptic_transmissio1.74500989
30MP0003718_maternal_effect1.74132134
31MP0002063_abnormal_learning/memory/cond1.72701012
32MP0003123_paternal_imprinting1.69345966
33MP0004859_abnormal_synaptic_plasticity1.67301106
34MP0003878_abnormal_ear_physiology1.64638433
35MP0005377_hearing/vestibular/ear_phenot1.64638433
36MP0002572_abnormal_emotion/affect_behav1.64624891
37MP0002064_seizures1.63792058
38MP0002163_abnormal_gland_morphology1.60886068
39MP0000778_abnormal_nervous_system1.59111768
40MP0003221_abnormal_cardiomyocyte_apopto1.59039619
41MP0008260_abnormal_autophagy1.54604078
42MP0009697_abnormal_copulation1.54317531
43MP0002638_abnormal_pupillary_reflex1.51723639
44MP0001293_anophthalmia1.51523148
45MP0002272_abnormal_nervous_system1.50569830
46MP0004147_increased_porphyrin_level1.46678508
47MP0001486_abnormal_startle_reflex1.41959171
48MP0002653_abnormal_ependyma_morphology1.34300323
49MP0010030_abnormal_orbit_morphology1.33665746
50MP0005386_behavior/neurological_phenoty1.32666621
51MP0004924_abnormal_behavior1.32666621
52MP0003937_abnormal_limbs/digits/tail_de1.32630688
53MP0006035_abnormal_mitochondrial_morpho1.32529477
54MP0005084_abnormal_gallbladder_morpholo1.31132150
55MP0001177_atelectasis1.31063013
56MP0005253_abnormal_eye_physiology1.28300699
57MP0000647_abnormal_sebaceous_gland1.26838226
58MP0002233_abnormal_nose_morphology1.25370562
59MP0001764_abnormal_homeostasis1.25259406
60* MP0002210_abnormal_sex_determination1.25240986
61MP0009046_muscle_twitch1.25083247
62MP0003186_abnormal_redox_activity1.24193085
63MP0005379_endocrine/exocrine_gland_phen1.23705708
64MP0001970_abnormal_pain_threshold1.23088699
65MP0010094_abnormal_chromosome_stability1.22562442
66MP0008058_abnormal_DNA_repair1.22410768
67MP0001440_abnormal_grooming_behavior1.21649058
68MP0002067_abnormal_sensory_capabilities1.21133514
69* MP0001929_abnormal_gametogenesis1.19621978
70MP0002938_white_spotting1.17025799
71MP0002557_abnormal_social/conspecific_i1.15543583
72MP0002876_abnormal_thyroid_physiology1.15378222
73MP0002184_abnormal_innervation1.10439856
74MP0005408_hypopigmentation1.10401298
75MP0005171_absent_coat_pigmentation1.10218215
76MP0003119_abnormal_digestive_system1.10074600
77MP0004133_heterotaxia1.09978503
78MP0002751_abnormal_autonomic_nervous1.09564725
79MP0005187_abnormal_penis_morphology1.07820332
80MP0001730_embryonic_growth_arrest1.07774820
81MP0003567_abnormal_fetal_cardiomyocyte1.04472555
82MP0002090_abnormal_vision1.03030997
83MP0001542_abnormal_bone_strength1.01333799
84MP0002084_abnormal_developmental_patter1.00749021
85MP0002822_catalepsy1.00583576
86MP0001286_abnormal_eye_development1.00320897
87MP0001963_abnormal_hearing_physiology0.99466676
88MP0000955_abnormal_spinal_cord0.98420537
89MP0003861_abnormal_nervous_system0.98366302
90MP0004134_abnormal_chest_morphology0.97892950
91MP0005645_abnormal_hypothalamus_physiol0.97848724
92MP0000569_abnormal_digit_pigmentation0.96015185
93MP0000049_abnormal_middle_ear0.95801764
94MP0002234_abnormal_pharynx_morphology0.95653140
95MP0005551_abnormal_eye_electrophysiolog0.95307870
96MP0004957_abnormal_blastocyst_morpholog0.95120981
97* MP0000653_abnormal_sex_gland0.94388341
98MP0003315_abnormal_perineum_morphology0.93661216
99MP0006036_abnormal_mitochondrial_physio0.93341107
100MP0005391_vision/eye_phenotype0.92980246
101MP0008995_early_reproductive_senescence0.92885886
102MP0004811_abnormal_neuron_physiology0.92411650
103MP0004742_abnormal_vestibular_system0.92262217
104MP0001986_abnormal_taste_sensitivity0.92215577
105MP0003136_yellow_coat_color0.91701583
106MP0002160_abnormal_reproductive_system0.91589229
107* MP0001145_abnormal_male_reproductive0.91325679
108MP0003890_abnormal_embryonic-extraembry0.91031975
109MP0008007_abnormal_cellular_replicative0.90908396
110MP0000350_abnormal_cell_proliferation0.89925101
111MP0000358_abnormal_cell_content/0.89180540
112MP0000631_abnormal_neuroendocrine_gland0.88485162
113MP0001697_abnormal_embryo_size0.87889833
114MP0001502_abnormal_circadian_rhythm0.87847876
115MP0004142_abnormal_muscle_tone0.87344789
116MP0008932_abnormal_embryonic_tissue0.87267883
117MP0003941_abnormal_skin_development0.86810208
118MP0008872_abnormal_physiological_respon0.86354152
119MP0000372_irregular_coat_pigmentation0.85634467
120MP0002085_abnormal_embryonic_tissue0.84773480
121MP0005389_reproductive_system_phenotype0.84099660
122* MP0003698_abnormal_male_reproductive0.83890731
123MP0000026_abnormal_inner_ear0.83453548
124MP0003111_abnormal_nucleus_morphology0.82838518
125MP0004883_abnormal_blood_vessel0.82816206
126MP0000015_abnormal_ear_pigmentation0.82528087
127MP0001485_abnormal_pinna_reflex0.82439125
128MP0000566_synostosis0.81017488
129MP0003195_calcinosis0.80547839
130MP0000762_abnormal_tongue_morphology0.80138279
131MP0002697_abnormal_eye_size0.79302926
132MP0002152_abnormal_brain_morphology0.78702499
133MP0003077_abnormal_cell_cycle0.78038327
134MP0003938_abnormal_ear_development0.77600175
135MP0008875_abnormal_xenobiotic_pharmacok0.77197091
136MP0003755_abnormal_palate_morphology0.76363051
137MP0002733_abnormal_thermal_nociception0.75933719
138MP0002882_abnormal_neuron_morphology0.75109728
139MP0004782_abnormal_surfactant_physiolog0.74763634
140MP0005423_abnormal_somatic_nervous0.74449603
141MP0010368_abnormal_lymphatic_system0.74388168
142MP0005409_darkened_coat_color0.73078934

Predicted human phenotypes

RankGene SetZ-score
1Submucous cleft hard palate (HP:0000176)4.00514688
2Urethral obstruction (HP:0000796)3.91397526
3Focal motor seizures (HP:0011153)3.83339453
4Hydroureter (HP:0000072)3.81832643
5Abnormal hair whorl (HP:0010721)3.42078247
6Shoulder girdle muscle weakness (HP:0003547)3.29523964
7Atonic seizures (HP:0010819)3.28885949
8Cortical dysplasia (HP:0002539)3.25565244
9Abnormality of the labia minora (HP:0012880)3.15121936
10Acute necrotizing encephalopathy (HP:0006965)3.03838861
11Febrile seizures (HP:0002373)2.77807918
12Volvulus (HP:0002580)2.73134503
13Birth length less than 3rd percentile (HP:0003561)2.72507040
14Abnormality of glycolysis (HP:0004366)2.67757297
15Increased serum pyruvate (HP:0003542)2.67757297
16Cerebral hypomyelination (HP:0006808)2.66147563
17Hyperventilation (HP:0002883)2.61732898
18Medial flaring of the eyebrow (HP:0010747)2.59994786
19Abnormal mitochondria in muscle tissue (HP:0008316)2.57005702
20Meckel diverticulum (HP:0002245)2.55813853
21Mitochondrial inheritance (HP:0001427)2.54965188
22Adrenal hypoplasia (HP:0000835)2.54024186
23Progressive macrocephaly (HP:0004481)2.52773536
24Pelvic girdle muscle weakness (HP:0003749)2.50214501
25Hypothermia (HP:0002045)2.48577959
26Epileptic encephalopathy (HP:0200134)2.46726981
27Abnormal tarsal ossification (HP:0008369)2.45813778
28Stomach cancer (HP:0012126)2.45387983
29Abnormality of the ileum (HP:0001549)2.44495021
30Dysautonomia (HP:0002459)2.44310022
31Poor suck (HP:0002033)2.43848910
32Pancreatic fibrosis (HP:0100732)2.43695315
33Abnormal respiratory motile cilium morphology (HP:0005938)2.43450050
34Abnormal respiratory epithelium morphology (HP:0012253)2.43450050
35Gait imbalance (HP:0002141)2.43225221
36Progressive cerebellar ataxia (HP:0002073)2.42672769
37Degeneration of anterior horn cells (HP:0002398)2.42171426
38Abnormality of the anterior horn cell (HP:0006802)2.42171426
39Postnatal microcephaly (HP:0005484)2.41715409
40Aplasia/Hypoplasia of the uvula (HP:0010293)2.41123030
41Abnormality of midbrain morphology (HP:0002418)2.38775419
42Molar tooth sign on MRI (HP:0002419)2.38775419
43Abnormality of the hip-girdle musculature (HP:0001445)2.35667814
44Abnormality of the musculature of the pelvis (HP:0001469)2.35667814
45Abnormality of chromosome stability (HP:0003220)2.35503020
46Fair hair (HP:0002286)2.33442259
47Increased CSF lactate (HP:0002490)2.33343495
48Upper limb muscle weakness (HP:0003484)2.31786768
49Methylmalonic acidemia (HP:0002912)2.30314695
50Abnormal lung lobation (HP:0002101)2.28885941
51Increased hepatocellular lipid droplets (HP:0006565)2.27788474
52Congenital primary aphakia (HP:0007707)2.27278334
53CNS hypomyelination (HP:0003429)2.27056504
54Autoamputation (HP:0001218)2.25962922
55Intestinal atresia (HP:0011100)2.21243089
56Acute encephalopathy (HP:0006846)2.19843100
57Breast aplasia (HP:0100783)2.19668700
58Colon cancer (HP:0003003)2.18719224
59Poor coordination (HP:0002370)2.18693071
60Abnormal autonomic nervous system physiology (HP:0012332)2.15465408
61Nephrogenic diabetes insipidus (HP:0009806)2.14582166
62Oligodactyly (hands) (HP:0001180)2.13958727
63Stenosis of the external auditory canal (HP:0000402)2.13570204
64True hermaphroditism (HP:0010459)2.12116633
65Abnormality of the preputium (HP:0100587)2.10505884
66Abnormal ciliary motility (HP:0012262)2.09875365
67Breast hypoplasia (HP:0003187)2.08386454
68Medulloblastoma (HP:0002885)2.08320418
69Chromsome breakage (HP:0040012)2.08152599
70Atrophy/Degeneration involving motor neurons (HP:0007373)2.08101204
71Papillary thyroid carcinoma (HP:0002895)2.07856371
72Chromosomal breakage induced by crosslinking agents (HP:0003221)2.06937700
73Renal Fanconi syndrome (HP:0001994)2.06729198
74Hypoplastic pelvis (HP:0008839)2.06312225
75Congenital, generalized hypertrichosis (HP:0004540)2.04999928
76Absence seizures (HP:0002121)2.04861617
77Aplasia/Hypoplasia of the fovea (HP:0008060)2.04205901
78Hypoplasia of the fovea (HP:0007750)2.04205901
79Abnormality of the metopic suture (HP:0005556)2.03706072
80Entropion (HP:0000621)2.01786004
81Polyphagia (HP:0002591)2.01526128
82Aplasia/Hypoplasia of the breasts (HP:0010311)1.99134851
83Neoplasm of the tracheobronchial system (HP:0100552)1.98788984
84Cupped ear (HP:0000378)1.94777357
85Prominent metopic ridge (HP:0005487)1.94755974
86Supernumerary spleens (HP:0009799)1.93615034
87Focal seizures (HP:0007359)1.93516245
88Impulsivity (HP:0100710)1.93064646
89Increased serum lactate (HP:0002151)1.92668370
90Dialeptic seizures (HP:0011146)1.92609563
91Limb dystonia (HP:0002451)1.89997858
92Generalized hypopigmentation of hair (HP:0011358)1.89888538
93Genital tract atresia (HP:0001827)1.89851373
94Absent eyebrow (HP:0002223)1.89081643
95Progressive inability to walk (HP:0002505)1.87636288
96Muscular hypotonia of the trunk (HP:0008936)1.87573204
97Protruding tongue (HP:0010808)1.87288529
98Absent septum pellucidum (HP:0001331)1.86924026
99Nephronophthisis (HP:0000090)1.86308431
100Abnormality of the pons (HP:0007361)1.85507525
101Cerebral edema (HP:0002181)1.84617032
102Lissencephaly (HP:0001339)1.84611421
103Alveolar cell carcinoma (HP:0006519)1.84222611
1043-Methylglutaconic aciduria (HP:0003535)1.83786205
105Stillbirth (HP:0003826)1.83651065
106Vaginal atresia (HP:0000148)1.83177728
107Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.82974187
108Small intestinal stenosis (HP:0012848)1.82590914
109Duodenal stenosis (HP:0100867)1.82590914
110Delusions (HP:0000746)1.82210182
111Abnormality of the septum pellucidum (HP:0007375)1.81674753
112Gaze-evoked nystagmus (HP:0000640)1.81508401
113Nasolacrimal duct obstruction (HP:0000579)1.80397810
114Glioma (HP:0009733)1.80345761
115Lipid accumulation in hepatocytes (HP:0006561)1.79248681
116Septo-optic dysplasia (HP:0100842)1.78939067
117Horseshoe kidney (HP:0000085)1.78710277
118Abnormal large intestine physiology (HP:0012700)1.77128586
119Abnormality of the duodenum (HP:0002246)1.76376651
120Oligodactyly (HP:0012165)1.76219452
121Abnormal respiratory motile cilium physiology (HP:0012261)1.76098208
122Sloping forehead (HP:0000340)1.75897158
123Rimmed vacuoles (HP:0003805)1.75862675
124Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.75610508
125Abnormality of alanine metabolism (HP:0010916)1.75610508
126Hyperalaninemia (HP:0003348)1.75610508
127Retinal dysplasia (HP:0007973)1.75243819
128Tubulointerstitial nephritis (HP:0001970)1.74285881
129Abnormality of the clitoris (HP:0000056)1.73716285
130Myokymia (HP:0002411)1.73691143
131Aplasia involving bones of the upper limbs (HP:0009823)1.73179120
132Aplasia of the phalanges of the hand (HP:0009802)1.73179120
133Aplasia involving bones of the extremities (HP:0009825)1.73179120
134Thyroid carcinoma (HP:0002890)1.73111961
135Abnormality of the fovea (HP:0000493)1.72845055
136Hemivertebrae (HP:0002937)1.72536642
137Hepatic necrosis (HP:0002605)1.71902748
138Abnormal foot bone ossification (HP:0010675)1.71425006
139Rough bone trabeculation (HP:0100670)1.71363616
140Ependymoma (HP:0002888)1.71194467
141Hypoplastic female external genitalia (HP:0012815)1.70458908
142Bowel incontinence (HP:0002607)1.70303126
143Rhabdomyosarcoma (HP:0002859)1.70060898
144Narrow forehead (HP:0000341)1.69653092
145Capillary hemangiomas (HP:0005306)1.68807193
146Pancreatic cysts (HP:0001737)1.68397721
147Pendular nystagmus (HP:0012043)1.67894069
148Aplasia/Hypoplasia of the tibia (HP:0005772)1.67809140
149Microvesicular hepatic steatosis (HP:0001414)1.67677191
150Respiratory difficulties (HP:0002880)1.67608206
151Preaxial hand polydactyly (HP:0001177)1.67563813
152Generalized tonic-clonic seizures (HP:0002069)1.66615139
153Methylmalonic aciduria (HP:0012120)1.66144083
154Short tibia (HP:0005736)1.66127892
155Hepatocellular necrosis (HP:0001404)1.65619355
156Drooling (HP:0002307)1.64528412
157Abnormality of the corticospinal tract (HP:0002492)1.64336829
158Urinary urgency (HP:0000012)1.64212617
159Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.63784587
160Degeneration of the lateral corticospinal tracts (HP:0002314)1.63784587
161Labial hypoplasia (HP:0000066)1.63769345
162Rhinitis (HP:0012384)1.63054594
163Gonadotropin excess (HP:0000837)1.62443969
164Abnormality of the lacrimal duct (HP:0011481)1.61545321

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TSSK65.17972862
2AKT33.58715471
3TRIM283.49382449
4CASK3.21440125
5PNCK3.02459720
6NEK12.53426269
7BUB12.30939004
8STK162.27183578
9FRK2.18560943
10CDC71.97261130
11MAP3K121.96345592
12TTK1.91822503
13PLK31.88158401
14MKNK21.81592995
15MAP2K71.81317763
16NUAK11.80316698
17PLK21.79504425
18WEE11.73733078
19BCR1.65621289
20MAP4K21.61866806
21CSNK1G31.55141922
22CSNK1A1L1.52371930
23NEK61.45380478
24MARK11.45369457
25MKNK11.45210135
26NTRK31.44564441
27BMPR1B1.40247879
28MAPKAPK51.37902255
29VRK11.37679140
30CCNB11.37348160
31PLK41.35594017
32MAP3K41.34067350
33MAPK131.31210598
34ZAK1.28377945
35EIF2AK11.26046198
36OXSR11.25867622
37SRPK11.25154598
38ARAF1.24603712
39MAP2K41.21964849
40DYRK31.21675963
41SIK31.19498717
42BRAF1.19439190
43WNK31.19148642
44CDK81.18917257
45CSNK1G21.17911333
46CSNK1G11.17681070
47EPHA21.16261954
48PBK1.13430840
49GRK51.12067012
50NME11.09928140
51EIF2AK31.03737449
52PDK21.02886889
53VRK21.01595245
54MINK11.00743305
55EPHA40.97143448
56ACVR1B0.93961894
57BMPR20.90593694
58MST40.88665806
59SGK20.86832664
60RPS6KA40.85572023
61BRSK20.84715454
62ERBB30.84252808
63STK390.83184793
64TAF10.79889540
65SGK4940.79337359
66SGK2230.79337359
67DYRK20.79302300
68PRKCG0.78022601
69PASK0.73609187
70PRKCE0.72665587
71CDK30.70590062
72ATR0.70062853
73IRAK30.68887295
74ADRBK20.68466926
75DYRK1A0.68392090
76STK38L0.67730331
77LIMK10.67132991
78KSR10.66830573
79DAPK20.65099936
80PINK10.65060385
81INSRR0.65035979
82ERBB40.64481327
83AURKB0.62989301
84CAMK2B0.62412734
85PDK40.61277455
86PDK30.61277455
87BRD40.59565113
88CDK190.58277884
89ATM0.58071850
90TIE10.56738313
91PLK10.55570761
92MAP3K90.54902458
93BRSK10.54394502
94GRK70.53779877
95PIM20.53337540
96PAK30.52931676
97ALK0.52722430
98AURKA0.52721814
99PRKCI0.52030184
100CHEK10.51159431
101UHMK10.50629054
102EIF2AK20.50467743
103LATS20.50300688
104GRK10.48063212
105MAPK150.46401537
106CSNK1A10.45403379
107CAMK2A0.44130648
108PRPF4B0.43770653
109CHEK20.42659590
110CDK140.42578304
111CSNK1E0.41017619
112CSNK2A10.39045583
113TNIK0.38575428
114CDK180.38349424
115DAPK10.38256523
116STK240.36310962
117MAP3K50.35908045
118CSNK2A20.34402910
119NTRK20.34251597
120TGFBR10.34234060
121YES10.33752699
122CDK150.33477574
123CDK50.33360955
124TNK20.33111780
125CDK10.32930901
126STK30.32567901
127EPHB20.32045548
128CDK11A0.31020862
129BCKDK0.31006792
130FGFR10.28118419
131NEK20.27966665

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.15880462
2Vitamin B6 metabolism_Homo sapiens_hsa007503.47417901
3RNA polymerase_Homo sapiens_hsa030203.15761964
4Collecting duct acid secretion_Homo sapiens_hsa049662.99202658
5Oxidative phosphorylation_Homo sapiens_hsa001902.83973909
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.59768030
7Nicotine addiction_Homo sapiens_hsa050332.54751130
8Basal transcription factors_Homo sapiens_hsa030222.39848235
9Synaptic vesicle cycle_Homo sapiens_hsa047212.29240731
10Parkinsons disease_Homo sapiens_hsa050122.17086502
11Regulation of autophagy_Homo sapiens_hsa041402.02825574
12Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.97378499
13Protein export_Homo sapiens_hsa030601.95146498
14Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.84763283
15RNA transport_Homo sapiens_hsa030131.81451094
16Huntingtons disease_Homo sapiens_hsa050161.77862735
17Propanoate metabolism_Homo sapiens_hsa006401.70820783
18Spliceosome_Homo sapiens_hsa030401.64630093
19Rheumatoid arthritis_Homo sapiens_hsa053231.62266431
20Amphetamine addiction_Homo sapiens_hsa050311.53658941
21Nucleotide excision repair_Homo sapiens_hsa034201.52155523
22Vibrio cholerae infection_Homo sapiens_hsa051101.51897853
23Alzheimers disease_Homo sapiens_hsa050101.47604769
24Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.33808073
25Pyrimidine metabolism_Homo sapiens_hsa002401.30334805
26Graft-versus-host disease_Homo sapiens_hsa053321.26338028
27Pyruvate metabolism_Homo sapiens_hsa006201.24268638
28Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.24139109
29Taste transduction_Homo sapiens_hsa047421.24095054
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.20370081
31Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.20336665
32Steroid biosynthesis_Homo sapiens_hsa001001.18942914
33GABAergic synapse_Homo sapiens_hsa047271.18669110
34RNA degradation_Homo sapiens_hsa030181.18594511
35Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.17768697
36Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.15796615
37Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.15520330
38Cell cycle_Homo sapiens_hsa041101.14608487
39Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.14566963
40Purine metabolism_Homo sapiens_hsa002301.11588984
41Oocyte meiosis_Homo sapiens_hsa041141.11202799
42Selenocompound metabolism_Homo sapiens_hsa004501.10670464
43Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.10545046
44Serotonergic synapse_Homo sapiens_hsa047261.09886312
45Steroid hormone biosynthesis_Homo sapiens_hsa001401.08310809
46One carbon pool by folate_Homo sapiens_hsa006701.06634671
47Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.04180848
482-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.02422917
49Drug metabolism - other enzymes_Homo sapiens_hsa009831.01445888
50Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.99394912
51Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.99309644
52mRNA surveillance pathway_Homo sapiens_hsa030150.99169199
53Dopaminergic synapse_Homo sapiens_hsa047280.96529262
54African trypanosomiasis_Homo sapiens_hsa051430.93517948
55Homologous recombination_Homo sapiens_hsa034400.93498948
56Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.92582239
57Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.90114958
58Mismatch repair_Homo sapiens_hsa034300.89711868
59Morphine addiction_Homo sapiens_hsa050320.89416681
60Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.89236953
61Biosynthesis of amino acids_Homo sapiens_hsa012300.86938615
62Butanoate metabolism_Homo sapiens_hsa006500.85125337
63Prion diseases_Homo sapiens_hsa050200.84119197
64Olfactory transduction_Homo sapiens_hsa047400.83772536
65Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.82750864
66Long-term potentiation_Homo sapiens_hsa047200.82457387
67Epstein-Barr virus infection_Homo sapiens_hsa051690.82065815
68Carbon metabolism_Homo sapiens_hsa012000.79638095
69Vitamin digestion and absorption_Homo sapiens_hsa049770.75915958
70SNARE interactions in vesicular transport_Homo sapiens_hsa041300.75331207
71Glutamatergic synapse_Homo sapiens_hsa047240.75189788
72Circadian rhythm_Homo sapiens_hsa047100.74610600
73Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.74171918
74Circadian entrainment_Homo sapiens_hsa047130.73821253
75Caffeine metabolism_Homo sapiens_hsa002320.72760053
76Cocaine addiction_Homo sapiens_hsa050300.72113496
77Phototransduction_Homo sapiens_hsa047440.71942298
78Fanconi anemia pathway_Homo sapiens_hsa034600.71574193
79Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.70980926
80p53 signaling pathway_Homo sapiens_hsa041150.70940540
81Phagosome_Homo sapiens_hsa041450.68959087
82Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.68928092
83Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.68046036
84* Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.67617680
85Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.62460899
86Maturity onset diabetes of the young_Homo sapiens_hsa049500.62154678
87Axon guidance_Homo sapiens_hsa043600.61313929
88Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.59882734
89beta-Alanine metabolism_Homo sapiens_hsa004100.58614843
90Ribosome_Homo sapiens_hsa030100.58388810
91Cysteine and methionine metabolism_Homo sapiens_hsa002700.58071022
92Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.56884504
93Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.56083737
94Pentose and glucuronate interconversions_Homo sapiens_hsa000400.55682667
95Fatty acid metabolism_Homo sapiens_hsa012120.55354716
96Peroxisome_Homo sapiens_hsa041460.55079183
97Retinol metabolism_Homo sapiens_hsa008300.52406042
98Non-homologous end-joining_Homo sapiens_hsa034500.51700891
99Arginine and proline metabolism_Homo sapiens_hsa003300.51516856
100Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.50909466
101NOD-like receptor signaling pathway_Homo sapiens_hsa046210.49674464
102Intestinal immune network for IgA production_Homo sapiens_hsa046720.49613479
103Fatty acid elongation_Homo sapiens_hsa000620.48576773
104Ether lipid metabolism_Homo sapiens_hsa005650.47802341
105Primary bile acid biosynthesis_Homo sapiens_hsa001200.46681980
106Tryptophan metabolism_Homo sapiens_hsa003800.45011332
107ABC transporters_Homo sapiens_hsa020100.44939789
108Hippo signaling pathway_Homo sapiens_hsa043900.44833638
109Base excision repair_Homo sapiens_hsa034100.43721774
110Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.43531766
111Legionellosis_Homo sapiens_hsa051340.43435443
112Long-term depression_Homo sapiens_hsa047300.42798113
113Metabolic pathways_Homo sapiens_hsa011000.42144261
114DNA replication_Homo sapiens_hsa030300.41327366
115Cardiac muscle contraction_Homo sapiens_hsa042600.40731705
116Folate biosynthesis_Homo sapiens_hsa007900.39010569
117Type I diabetes mellitus_Homo sapiens_hsa049400.37947768
118Autoimmune thyroid disease_Homo sapiens_hsa053200.36870461
119Hedgehog signaling pathway_Homo sapiens_hsa043400.35147593
120FoxO signaling pathway_Homo sapiens_hsa040680.34847194
121TGF-beta signaling pathway_Homo sapiens_hsa043500.34095281
122Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.33681220
123Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.33507173
124Aldosterone synthesis and secretion_Homo sapiens_hsa049250.33365795
125Insulin secretion_Homo sapiens_hsa049110.33262302
126Sulfur metabolism_Homo sapiens_hsa009200.33188303
127Renin secretion_Homo sapiens_hsa049240.31871891
128Calcium signaling pathway_Homo sapiens_hsa040200.31351487
129Glutathione metabolism_Homo sapiens_hsa004800.30036992
130N-Glycan biosynthesis_Homo sapiens_hsa005100.24118295
131Fatty acid degradation_Homo sapiens_hsa000710.22005176
132Wnt signaling pathway_Homo sapiens_hsa043100.20455402
133Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.19107054

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