ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	4.96833087
2	proteasome assembly (GO:0043248)	4.95863448
3	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	4.24903041
4	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	4.22882355
5	rRNA modification (GO:0000154)	4.21367955
6	water-soluble vitamin biosynthetic process (GO:0042364)	4.13452015
7	DNA double-strand break processing (GO:0000729)	4.08338804
8	respiratory chain complex IV assembly (GO:0008535)	4.01406067
9	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.90770014
10	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.90396431
11	DNA catabolic process, exonucleolytic (GO:0000738)	3.85515790
12	ATP synthesis coupled proton transport (GO:0015986)	3.83932942
13	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.83932942
14	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	3.70774076
15	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.66898029
16	negative regulation of thymocyte apoptotic process (GO:0070244)	3.64830097
17	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.62245805
18	purine nucleobase biosynthetic process (GO:0009113)	3.61044932
19	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	3.59361758
20	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	3.59361758
21	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	3.59361758
22	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	3.59262136
23	cytochrome complex assembly (GO:0017004)	3.58802393
24	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	3.57301071
25	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.56716726
26	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.56716726
27	nucleobase biosynthetic process (GO:0046112)	3.56372746
28	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	3.50312031
29	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	3.50312031
30	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	3.45072089
31	negative regulation of ligase activity (GO:0051352)	3.45072089
32	branched-chain amino acid catabolic process (GO:0009083)	3.43239069
33	ribosomal large subunit biogenesis (GO:0042273)	3.42206578
34	signal transduction involved in DNA damage checkpoint (GO:0072422)	3.41088174
35	signal transduction involved in DNA integrity checkpoint (GO:0072401)	3.41088174
36	regulation of cellular amino acid metabolic process (GO:0006521)	3.36251309
37	rRNA methylation (GO:0031167)	3.34544081
38	adenosine metabolic process (GO:0046085)	3.33547919
39	pseudouridine synthesis (GO:0001522)	3.33264254
40	signal transduction involved in cell cycle checkpoint (GO:0072395)	3.33024199
41	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	3.32418587
42	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.29610937
43	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.29340209
44	termination of RNA polymerase III transcription (GO:0006386)	3.29340209
45	protein neddylation (GO:0045116)	3.25435582
46	B cell mediated immunity (GO:0019724)	3.22056175
47	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	3.16507475
48	somatic hypermutation of immunoglobulin genes (GO:0016446)	3.15533785
49	somatic diversification of immune receptors via somatic mutation (GO:0002566)	3.15533785
50	spliceosomal snRNP assembly (GO:0000387)	3.10739105
51	positive regulation of ligase activity (GO:0051351)	3.06753280
52	viral mRNA export from host cell nucleus (GO:0046784)	3.04682648
53	CENP-A containing nucleosome assembly (GO:0034080)	3.02858120
54	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:	3.01006786
55	platelet dense granule organization (GO:0060155)	2.95010120
56	piRNA metabolic process (GO:0034587)	2.93395971
57	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.92584907
58	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	2.92584907
59	isotype switching (GO:0045190)	2.92584907
60	chaperone-mediated protein transport (GO:0072321)	2.92478165
61	protein complex biogenesis (GO:0070271)	2.92279527
62	amino acid salvage (GO:0043102)	2.88675500
63	L-methionine salvage (GO:0071267)	2.88675500
64	L-methionine biosynthetic process (GO:0071265)	2.88675500
65	DNA replication checkpoint (GO:0000076)	2.88515515
66	ribosome assembly (GO:0042255)	2.88330639
67	antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)	2.86750237
68	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO	2.86711580
69	negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)	2.86509877
70	DNA damage response, detection of DNA damage (GO:0042769)	2.86464377
71	mitochondrial respiratory chain complex assembly (GO:0033108)	2.86239047
72	chromatin remodeling at centromere (GO:0031055)	2.83649087
73	branched-chain amino acid metabolic process (GO:0009081)	2.82824088
74	IMP biosynthetic process (GO:0006188)	2.81264444
75	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.80881923
76	DNA ligation (GO:0006266)	2.80515050
77	positive regulation of cell cycle arrest (GO:0071158)	2.77107921
78	tRNA metabolic process (GO:0006399)	2.75258181
79	tRNA processing (GO:0008033)	2.75219887
80	intra-S DNA damage checkpoint (GO:0031573)	2.74561300
81	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.72646082
82	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.72646082
83	NADH dehydrogenase complex assembly (GO:0010257)	2.72646082
84	DNA replication-dependent nucleosome assembly (GO:0006335)	2.71846231
85	DNA replication-dependent nucleosome organization (GO:0034723)	2.71846231
86	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:0000288)	2.71140382
87	purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)	2.68895864
88	regulation of helicase activity (GO:0051095)	2.68666664
89	antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)	2.67899180
90	cullin deneddylation (GO:0010388)	2.67759046
91	protein deneddylation (GO:0000338)	2.67746350
92	purine deoxyribonucleotide catabolic process (GO:0009155)	2.67701952
93	histone mRNA metabolic process (GO:0008334)	2.67666538
94	regulation of mitotic spindle checkpoint (GO:1903504)	2.67564612
95	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.67564612
96	regulation of centriole replication (GO:0046599)	2.67210235
97	histone exchange (GO:0043486)	2.66889795
98	postreplication repair (GO:0006301)	2.65949906
99	negative regulation of protein ubiquitination (GO:0031397)	2.64783444
100	deoxyribose phosphate catabolic process (GO:0046386)	2.64263883

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	5.16452277
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.24608233
3	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.84941122
4	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.91159918
5	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.85242750
6	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.84873943
7	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.80924384
8	E2F7_22180533_ChIP-Seq_HELA_Human	2.76737237
9	VDR_23849224_ChIP-Seq_CD4+_Human	2.70103004
10	ELK1_19687146_ChIP-ChIP_HELA_Human	2.69832526
11	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.68970713
12	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.59083551
13	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.58104713
14	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.52744252
15	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.51389226
16	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	2.51208276
17	FOXP3_21729870_ChIP-Seq_TREG_Human	2.43851182
18	VDR_22108803_ChIP-Seq_LS180_Human	2.38385054
19	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.34197412
20	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.32536674
21	GATA1_22025678_ChIP-Seq_K562_Human	2.27079309
22	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.24470060
23	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.17115135
24	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.08531247
25	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	2.01071969
26	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.00109078
27	ZNF274_21170338_ChIP-Seq_K562_Hela	1.99185155
28	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.96664834
29	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.96489501
30	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.96454524
31	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.92986484
32	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.92128660
33	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.91784588
34	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.71116808
35	EWS_26573619_Chip-Seq_HEK293_Human	1.69958787
36	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.68733664
37	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.65659393
38	DCP1A_22483619_ChIP-Seq_HELA_Human	1.62367432
39	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.60901544
40	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.60253870
41	IGF1R_20145208_ChIP-Seq_DFB_Human	1.57893490
42	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.56710241
43	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.56257038
44	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.52586272
45	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.46813219
46	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.43471872
47	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.41688235
48	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.39337057
49	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.35277549
50	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.35172640
51	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.32927805
52	GABP_19822575_ChIP-Seq_HepG2_Human	1.31718149
53	TTF2_22483619_ChIP-Seq_HELA_Human	1.31258435
54	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.29437393
55	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.27944904
56	GATA3_26560356_Chip-Seq_TH2_Human	1.26517043
57	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.25168347
58	CIITA_25753668_ChIP-Seq_RAJI_Human	1.23169878
59	SPI1_23547873_ChIP-Seq_NB4_Human	1.21783141
60	TAF15_26573619_Chip-Seq_HEK293_Human	1.18881095
61	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.18166788
62	SOX2_19829295_ChIP-Seq_ESCs_Human	1.14852431
63	NANOG_19829295_ChIP-Seq_ESCs_Human	1.14852431
64	MYC_18940864_ChIP-ChIP_HL60_Human	1.14043356
65	ER_23166858_ChIP-Seq_MCF-7_Human	1.13858969
66	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.13208650
67	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	1.11646063
68	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.09568845
69	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.08241916
70	MYB_26560356_Chip-Seq_TH2_Human	1.07312431
71	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.07267480
72	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.05997694
73	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.05997694
74	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.05165347
75	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.04488141
76	AR_20517297_ChIP-Seq_VCAP_Human	1.04372309
77	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.00437082
78	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.00025547
79	TP53_22573176_ChIP-Seq_HFKS_Human	0.99632739
80	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.99202210
81	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.98833228
82	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	0.97963124
83	E2F1_21310950_ChIP-Seq_MCF-7_Human	0.97265691
84	ERG_20887958_ChIP-Seq_HPC-7_Mouse	0.96406656
85	P300_19829295_ChIP-Seq_ESCs_Human	0.95613695
86	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.94970870
87	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	0.94428420
88	POU3F2_20337985_ChIP-ChIP_501MEL_Human	0.94288615
89	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.92755023
90	FUS_26573619_Chip-Seq_HEK293_Human	0.92301525
91	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	0.91211522
92	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.90592718
93	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.90538519
94	BP1_19119308_ChIP-ChIP_Hs578T_Human	0.88821770
95	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.88299503
96	IRF1_19129219_ChIP-ChIP_H3396_Human	0.87696331
97	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.86145060
98	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.86083806
99	CDX2_22108803_ChIP-Seq_LS180_Human	0.85315391
100	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.83980525

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003724_increased_susceptibility_to	3.39216943
2	MP0001835_abnormal_antigen_presentation	3.36958162
3	MP0009697_abnormal_copulation	2.99517292
4	MP0004147_increased_porphyrin_level	2.94766231
5	MP0003806_abnormal_nucleotide_metabolis	2.83720439
6	MP0005671_abnormal_response_to	2.82192367
7	MP0008058_abnormal_DNA_repair	2.53560229
8	MP0002138_abnormal_hepatobiliary_system	2.53157304
9	MP0010094_abnormal_chromosome_stability	2.41522943
10	MP0006054_spinal_hemorrhage	2.36649648
11	MP0002148_abnormal_hypersensitivity_rea	2.29066602
12	MP0008872_abnormal_physiological_respon	2.28641735
13	MP0005646_abnormal_pituitary_gland	2.21933015
14	MP0006036_abnormal_mitochondrial_physio	1.99090542
15	MP0008877_abnormal_DNA_methylation	1.86939050
16	MP0009785_altered_susceptibility_to	1.85320713
17	MP0001800_abnormal_humoral_immune	1.85073395
18	MP0000685_abnormal_immune_system	1.83602046
19	MP0002736_abnormal_nociception_after	1.80322848
20	MP0005000_abnormal_immune_tolerance	1.77620464
21	MP0003786_premature_aging	1.76777854
22	MP0003718_maternal_effect	1.74036863
23	MP0004957_abnormal_blastocyst_morpholog	1.72720301
24	MP0003186_abnormal_redox_activity	1.71191506
25	MP0005645_abnormal_hypothalamus_physiol	1.70848100
26	MP0005075_abnormal_melanosome_morpholog	1.68317583
27	MP0002254_reproductive_system_inflammat	1.67431948
28	MP0005084_abnormal_gallbladder_morpholo	1.64088564
29	MP0003646_muscle_fatigue	1.61965860
30	MP0003303_peritoneal_inflammation	1.61535641
31	MP0003693_abnormal_embryo_hatching	1.60007847
32	MP0009333_abnormal_splenocyte_physiolog	1.59964855
33	MP0001764_abnormal_homeostasis	1.59870501
34	MP0001529_abnormal_vocalization	1.56966505
35	MP0002452_abnormal_antigen_presenting	1.50795930
36	MP0006035_abnormal_mitochondrial_morpho	1.47358548
37	MP0002102_abnormal_ear_morphology	1.45463029
38	MP0002006_tumorigenesis	1.43850991
39	MP0001968_abnormal_touch/_nociception	1.41187172
40	MP0002166_altered_tumor_susceptibility	1.39867428
41	MP0005379_endocrine/exocrine_gland_phen	1.39616334
42	MP0005167_abnormal_blood-brain_barrier	1.38901413
43	MP0002723_abnormal_immune_serum	1.38379430
44	MP0000372_irregular_coat_pigmentation	1.34738104
45	MP0001819_abnormal_immune_cell	1.33817113
46	MP0009764_decreased_sensitivity_to	1.32545598
47	MP0002420_abnormal_adaptive_immunity	1.30766074
48	MP0010368_abnormal_lymphatic_system	1.27779585
49	MP0002163_abnormal_gland_morphology	1.27120866
50	MP0001790_abnormal_immune_system	1.26008859
51	MP0005387_immune_system_phenotype	1.26008859
52	MP0003111_abnormal_nucleus_morphology	1.23222673
53	MP0006072_abnormal_retinal_apoptosis	1.20923606
54	MP0002398_abnormal_bone_marrow	1.19809798
55	MP0008007_abnormal_cellular_replicative	1.17524609
56	MP0010155_abnormal_intestine_physiology	1.16086931
57	MP0003763_abnormal_thymus_physiology	1.14554162
58	MP0000689_abnormal_spleen_morphology	1.12893997
59	MP0005025_abnormal_response_to	1.11184247
60	MP0004215_abnormal_myocardial_fiber	1.09109967
61	MP0002277_abnormal_respiratory_mucosa	1.08093459
62	MP0003077_abnormal_cell_cycle	1.05095064
63	MP0003787_abnormal_imprinting	1.03756314
64	MP0003890_abnormal_embryonic-extraembry	1.03499569
65	MP0003866_abnormal_defecation	1.00887962
66	MP0009278_abnormal_bone_marrow	0.99086488
67	MP0003195_calcinosis	0.98609548
68	MP0002405_respiratory_system_inflammati	0.97276799
69	MP0001845_abnormal_inflammatory_respons	0.95816679
70	MP0003075_altered_response_to	0.95443624
71	MP0001545_abnormal_hematopoietic_system	0.94956689
72	MP0005397_hematopoietic_system_phenotyp	0.94956689
73	MP0008873_increased_physiological_sensi	0.94368676
74	MP0000716_abnormal_immune_system	0.93741813
75	MP0008875_abnormal_xenobiotic_pharmacok	0.93068329
76	MP0000358_abnormal_cell_content/	0.92049600
77	MP0002429_abnormal_blood_cell	0.91823419
78	MP0003638_abnormal_response/metabolism_	0.90685383
79	MP0001986_abnormal_taste_sensitivity	0.85432444
80	MP0005636_abnormal_mineral_homeostasis	0.85211066
81	MP0000490_abnormal_crypts_of	0.84565567
82	MP0005464_abnormal_platelet_physiology	0.82835734
83	MP0001293_anophthalmia	0.82388643
84	MP0002837_dystrophic_cardiac_calcinosis	0.81987178
85	MP0002419_abnormal_innate_immunity	0.81214797
86	MP0002722_abnormal_immune_system	0.79713183
87	MP0001873_stomach_inflammation	0.79428953
88	MP0008004_abnormal_stomach_pH	0.78773229
89	MP0005389_reproductive_system_phenotype	0.78456806
90	MP0008469_abnormal_protein_level	0.78181933
91	MP0005332_abnormal_amino_acid	0.76986605
92	MP0001879_abnormal_lymphatic_vessel	0.76567582
93	MP0000639_abnormal_adrenal_gland	0.76497809
94	MP0005165_increased_susceptibility_to	0.76339419
95	MP0002396_abnormal_hematopoietic_system	0.75020288
96	MP0001929_abnormal_gametogenesis	0.71986547
97	MP0000465_gastrointestinal_hemorrhage	0.71838051
98	MP0004084_abnormal_cardiac_muscle	0.71655200
99	MP0002019_abnormal_tumor_incidence	0.70629614
100	MP0005085_abnormal_gallbladder_physiolo	0.68677017

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Type 2 muscle fiber atrophy (HP:0003554)	4.31279235
2	Methylmalonic acidemia (HP:0002912)	3.59087744
3	Muscle fiber atrophy (HP:0100295)	3.57156633
4	Acute necrotizing encephalopathy (HP:0006965)	3.56267971
5	Increased CSF lactate (HP:0002490)	3.56205958
6	Hepatocellular necrosis (HP:0001404)	3.51291125
7	Type I transferrin isoform profile (HP:0003642)	3.47848059
8	Hepatic necrosis (HP:0002605)	3.33919584
9	Mitochondrial inheritance (HP:0001427)	3.31973410
10	Acute encephalopathy (HP:0006846)	3.30961397
11	3-Methylglutaconic aciduria (HP:0003535)	3.23424944
12	Increased hepatocellular lipid droplets (HP:0006565)	3.20754886
13	Elevated erythrocyte sedimentation rate (HP:0003565)	3.14997532
14	Abnormal mitochondria in muscle tissue (HP:0008316)	3.11803152
15	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	3.11491665
16	Decreased activity of mitochondrial respiratory chain (HP:0008972)	3.11491665
17	Methylmalonic aciduria (HP:0012120)	3.05647001
18	Progressive macrocephaly (HP:0004481)	3.02827896
19	Lipid accumulation in hepatocytes (HP:0006561)	3.01026272
20	Reduced antithrombin III activity (HP:0001976)	2.99864241
21	Cerebral edema (HP:0002181)	2.96838475
22	IgG deficiency (HP:0004315)	2.95130147
23	Stomatitis (HP:0010280)	2.92894097
24	Increased serum lactate (HP:0002151)	2.91710228
25	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.86933797
26	Abnormality of alanine metabolism (HP:0010916)	2.86933797
27	Hyperalaninemia (HP:0003348)	2.86933797
28	Hyperglycinemia (HP:0002154)	2.79054858
29	Facial diplegia (HP:0001349)	2.67103037
30	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.65500491
31	Abnormal protein N-linked glycosylation (HP:0012347)	2.65500491
32	Abnormal protein glycosylation (HP:0012346)	2.65500491
33	Abnormal glycosylation (HP:0012345)	2.65500491
34	Degeneration of anterior horn cells (HP:0002398)	2.65355364
35	Abnormality of the anterior horn cell (HP:0006802)	2.65355364
36	Hypoproteinemia (HP:0003075)	2.63691935
37	Lethargy (HP:0001254)	2.56893188
38	IgM deficiency (HP:0002850)	2.55611883
39	Lactic acidosis (HP:0003128)	2.53765125
40	Panhypogammaglobulinemia (HP:0003139)	2.52612307
41	Abnormality of serum amino acid levels (HP:0003112)	2.51598825
42	Abnormality of methionine metabolism (HP:0010901)	2.48721070
43	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.48416855
44	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.47659798
45	Exertional dyspnea (HP:0002875)	2.47336230
46	Colon cancer (HP:0003003)	2.43481772
47	Abnormality of vitamin B metabolism (HP:0004340)	2.39855468
48	Abnormality of T cell physiology (HP:0011840)	2.36929453
49	Abnormality of serine family amino acid metabolism (HP:0010894)	2.32724053
50	Abnormality of glycine metabolism (HP:0010895)	2.32724053
51	Abnormality of B cell number (HP:0010975)	2.32723732
52	Pancreatic islet-cell hyperplasia (HP:0004510)	2.29087808
53	Hyperglycinuria (HP:0003108)	2.28178914
54	Respiratory failure (HP:0002878)	2.24014836
55	Abnormal delayed hypersensitivity skin test (HP:0002963)	2.19146158
56	Volvulus (HP:0002580)	2.17914978
57	Severe combined immunodeficiency (HP:0004430)	2.12057770
58	Increased intramyocellular lipid droplets (HP:0012240)	2.10200800
59	Ketosis (HP:0001946)	2.09823202
60	Renal Fanconi syndrome (HP:0001994)	2.09760445
61	Ketoacidosis (HP:0001993)	2.09619957
62	Spinal muscular atrophy (HP:0007269)	2.08503784
63	CNS demyelination (HP:0007305)	2.07925382
64	B lymphocytopenia (HP:0010976)	2.04528254
65	Pancreatic cysts (HP:0001737)	2.01188932
66	Congenital stationary night blindness (HP:0007642)	2.00786120
67	Abnormality of the prostate (HP:0008775)	1.99393300
68	Respiratory difficulties (HP:0002880)	1.98118679
69	Tongue fasciculations (HP:0001308)	1.97782168
70	Cerebral hypomyelination (HP:0006808)	1.96038401
71	Abnormality of the ileum (HP:0001549)	1.92288754
72	Intestinal atresia (HP:0011100)	1.89203837
73	Abolished electroretinogram (ERG) (HP:0000550)	1.88257715
74	Abnormality of the pancreatic islet cells (HP:0006476)	1.86294442
75	Abnormality of endocrine pancreas physiology (HP:0012093)	1.86294442
76	Meningioma (HP:0002858)	1.86278702
77	Hypothermia (HP:0002045)	1.84216439
78	Clubbing of toes (HP:0100760)	1.83482274
79	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.83322654
80	Dicarboxylic aciduria (HP:0003215)	1.83322654
81	Increased IgM level (HP:0003496)	1.82370344
82	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.81820579
83	Aplastic anemia (HP:0001915)	1.79942002
84	Albinism (HP:0001022)	1.79813181
85	Attenuation of retinal blood vessels (HP:0007843)	1.79765323
86	Abnormal spermatogenesis (HP:0008669)	1.78195701
87	Optic disc pallor (HP:0000543)	1.77521759
88	Prostate neoplasm (HP:0100787)	1.77434890
89	Stomach cancer (HP:0012126)	1.76552282
90	Palpitations (HP:0001962)	1.76036870
91	CNS hypomyelination (HP:0003429)	1.74738649
92	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.74618985
93	Microvesicular hepatic steatosis (HP:0001414)	1.74495842
94	Meckel diverticulum (HP:0002245)	1.74399636
95	Renal cortical cysts (HP:0000803)	1.73439231
96	Cerebral hemorrhage (HP:0001342)	1.72849585
97	Constricted visual fields (HP:0001133)	1.72696457
98	Pancytopenia (HP:0001876)	1.72225383
99	Combined immunodeficiency (HP:0005387)	1.71724082
100	Increased muscle lipid content (HP:0009058)	1.71065527

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TIE1	4.89978182
2	ZAK	3.40682667
3	EIF2AK3	3.32419543
4	PLK4	3.14007825
5	NUAK1	2.98194544
6	TAOK3	2.95695473
7	NEK1	2.77392002
8	VRK2	2.68799947
9	MKNK1	2.55727967
10	TLK1	2.32862007
11	MST4	2.12764420
12	MAP4K2	2.07694665
13	BCKDK	2.07250452
14	TSSK6	2.06781059
15	BMPR1B	1.99476620
16	VRK1	1.96814489
17	TEC	1.84967901
18	PLK3	1.82250883
19	MAP3K12	1.80845418
20	GRK1	1.74248315
21	TAF1	1.67900718
22	ADRBK2	1.67398215
23	WNK3	1.66249569
24	EIF2AK1	1.54545786
25	MKNK2	1.49288068
26	TRIM28	1.48592713
27	SRPK1	1.42691644
28	BUB1	1.38254636
29	KIT	1.37168828
30	BRSK2	1.26212508
31	SCYL2	1.16612630
32	WEE1	1.16139163
33	EIF2AK2	1.15830879
34	TTK	1.15359617
35	PBK	1.15342220
36	MYLK	1.15017495
37	ACVR1B	1.14773285
38	MAPKAPK5	1.14419360
39	FES	1.11745824
40	NME2	1.11161339
41	ERBB3	0.97530607
42	TXK	0.95671603
43	TGFBR1	0.92463611
44	STK16	0.92039770
45	CSNK1G3	0.89379031
46	PINK1	0.89332899
47	CDC7	0.89179844
48	IKBKB	0.88674257
49	BMPR2	0.87350868
50	MAP4K1	0.86680770
51	PDK2	0.86032422
52	TNIK	0.85893435
53	DAPK1	0.83438703
54	OXSR1	0.82499444
55	KDR	0.82396896
56	CSNK1G1	0.78711986
57	FRK	0.77265973
58	MAP3K14	0.72844544
59	IKBKE	0.70973744
60	PLK1	0.70680776
61	DYRK3	0.67212109
62	CSNK1G2	0.66828234
63	PRKCQ	0.61197261
64	CSNK1A1L	0.61193394
65	PASK	0.59675519
66	TNK2	0.59629000
67	BRAF	0.59295522
68	CCNB1	0.58492107
69	PIK3CG	0.58160900
70	SYK	0.56012956
71	RIPK4	0.55640835
72	MATK	0.52945714
73	RPS6KA5	0.52910737
74	TBK1	0.52680187
75	ITK	0.51507956
76	PLK2	0.49420002
77	AURKB	0.47121074
78	ALK	0.46142196
79	DAPK3	0.45832220
80	JAK3	0.45242892
81	LYN	0.44627980
82	GRK6	0.44113229
83	ATR	0.43310760
84	AKT3	0.43028040
85	PAK4	0.41040291
86	CHEK2	0.39003749
87	STK10	0.33659326
88	CSNK2A1	0.33439594
89	TESK2	0.32659855
90	INSRR	0.31108113
91	STK39	0.30368607
92	ADRBK1	0.24820842
93	CSNK2A2	0.24792235
94	IGF1R	0.24316086
95	RPS6KB2	0.24232474
96	MAP3K8	0.23756763
97	ILK	0.22226967
98	MAP3K13	0.21835139
99	CHUK	0.21025464
100	ATM	0.20855089

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	4.55823091
2	Asthma_Homo sapiens_hsa05310	2.99827071
3	Protein export_Homo sapiens_hsa03060	2.72097163
4	Allograft rejection_Homo sapiens_hsa05330	2.62833630
5	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.50900680
6	Mismatch repair_Homo sapiens_hsa03430	2.49504476
7	Oxidative phosphorylation_Homo sapiens_hsa00190	2.36509328
8	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.34727515
9	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.34333176
10	RNA polymerase_Homo sapiens_hsa03020	2.30947170
11	Homologous recombination_Homo sapiens_hsa03440	2.25852946
12	Type I diabetes mellitus_Homo sapiens_hsa04940	2.22750985
13	Graft-versus-host disease_Homo sapiens_hsa05332	2.15689584
14	Base excision repair_Homo sapiens_hsa03410	2.14502946
15	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	2.02289075
16	Parkinsons disease_Homo sapiens_hsa05012	2.00761117
17	One carbon pool by folate_Homo sapiens_hsa00670	1.95425600
18	Propanoate metabolism_Homo sapiens_hsa00640	1.94387090
19	RNA degradation_Homo sapiens_hsa03018	1.91154746
20	DNA replication_Homo sapiens_hsa03030	1.89482558
21	RNA transport_Homo sapiens_hsa03013	1.81970546
22	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.78533657
23	Basal transcription factors_Homo sapiens_hsa03022	1.76138686
24	Selenocompound metabolism_Homo sapiens_hsa00450	1.74398763
25	Ribosome_Homo sapiens_hsa03010	1.69836191
26	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.61560829
27	Non-homologous end-joining_Homo sapiens_hsa03450	1.57807645
28	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.57235831
29	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.48391874
30	Fanconi anemia pathway_Homo sapiens_hsa03460	1.48299240
31	Antigen processing and presentation_Homo sapiens_hsa04612	1.46828795
32	Spliceosome_Homo sapiens_hsa03040	1.37836292
33	Primary immunodeficiency_Homo sapiens_hsa05340	1.36953772
34	Nucleotide excision repair_Homo sapiens_hsa03420	1.33702021
35	Rheumatoid arthritis_Homo sapiens_hsa05323	1.25043645
36	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.20156812
37	Huntingtons disease_Homo sapiens_hsa05016	1.19927960
38	Sulfur metabolism_Homo sapiens_hsa00920	1.13102540
39	Pyrimidine metabolism_Homo sapiens_hsa00240	1.12511342
40	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.12451675
41	Fatty acid elongation_Homo sapiens_hsa00062	1.09166830
42	Regulation of autophagy_Homo sapiens_hsa04140	1.08893393
43	Viral myocarditis_Homo sapiens_hsa05416	1.07930512
44	Tryptophan metabolism_Homo sapiens_hsa00380	1.03939622
45	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.03688384
46	Alzheimers disease_Homo sapiens_hsa05010	1.01214832
47	Purine metabolism_Homo sapiens_hsa00230	1.00703750
48	Phototransduction_Homo sapiens_hsa04744	0.95625760
49	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.95081559
50	Linoleic acid metabolism_Homo sapiens_hsa00591	0.94153851
51	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.93990476
52	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.93944065
53	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.92703292
54	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.92684342
55	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.91287523
56	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.86872973
57	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.80985468
58	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.79629533
59	Herpes simplex infection_Homo sapiens_hsa05168	0.79618432
60	Legionellosis_Homo sapiens_hsa05134	0.78296488
61	Leishmaniasis_Homo sapiens_hsa05140	0.77039628
62	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.74455971
63	Glutathione metabolism_Homo sapiens_hsa00480	0.72754536
64	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.71698131
65	Peroxisome_Homo sapiens_hsa04146	0.66673372
66	Cell cycle_Homo sapiens_hsa04110	0.62591027
67	Collecting duct acid secretion_Homo sapiens_hsa04966	0.61036365
68	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.60090262
69	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.53903670
70	Butanoate metabolism_Homo sapiens_hsa00650	0.52618407
71	Caffeine metabolism_Homo sapiens_hsa00232	0.51029522
72	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.50168546
73	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.46470212
74	Fatty acid degradation_Homo sapiens_hsa00071	0.46342291
75	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.45120810
76	Ether lipid metabolism_Homo sapiens_hsa00565	0.44727943
77	Metabolic pathways_Homo sapiens_hsa01100	0.44608241
78	Influenza A_Homo sapiens_hsa05164	0.43819793
79	Pyruvate metabolism_Homo sapiens_hsa00620	0.43658282
80	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.43631243
81	mRNA surveillance pathway_Homo sapiens_hsa03015	0.39809355
82	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.39441182
83	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.38054781
84	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.37711937
85	Tuberculosis_Homo sapiens_hsa05152	0.36916211
86	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.36054373
87	Chemical carcinogenesis_Homo sapiens_hsa05204	0.35742338
88	p53 signaling pathway_Homo sapiens_hsa04115	0.33607559
89	Fatty acid metabolism_Homo sapiens_hsa01212	0.32809777
90	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.31783022
91	Toxoplasmosis_Homo sapiens_hsa05145	0.31160512
92	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.29590634
93	African trypanosomiasis_Homo sapiens_hsa05143	0.28498809
94	Measles_Homo sapiens_hsa05162	0.26825403
95	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.26728580
96	Retinol metabolism_Homo sapiens_hsa00830	0.26615783
97	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.26595537
98	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.23915293
99	Carbon metabolism_Homo sapiens_hsa01200	0.22331508
100	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.22294089

DNAJA1P2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »