ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA damage response, detection of DNA damage (GO:0042769)	5.19604376
2	DNA deamination (GO:0045006)	5.05399062
3	water-soluble vitamin biosynthetic process (GO:0042364)	4.65463371
4	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	4.58340789
5	proteasome assembly (GO:0043248)	4.39618682
6	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.23536360
7	protein neddylation (GO:0045116)	4.20800444
8	chaperone-mediated protein transport (GO:0072321)	4.15312601
9	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	4.10381946
10	respiratory chain complex IV assembly (GO:0008535)	4.02697656
11	rRNA modification (GO:0000154)	3.98054853
12	ATP synthesis coupled proton transport (GO:0015986)	3.97032330
13	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.97032330
14	regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)	3.95573523
15	otic vesicle formation (GO:0030916)	3.89521886
16	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.68767202
17	regulation of cellular amino acid metabolic process (GO:0006521)	3.68739634
18	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.67075169
19	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.67075169
20	regulation of regulatory T cell differentiation (GO:0045589)	3.59280339
21	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.58531444
22	rRNA methylation (GO:0031167)	3.55259120
23	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.54602532
24	termination of RNA polymerase III transcription (GO:0006386)	3.51743248
25	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.51743248
26	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.49331637
27	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	3.42556041
28	prenylation (GO:0097354)	3.35317679
29	protein prenylation (GO:0018342)	3.35317679
30	protein deneddylation (GO:0000338)	3.34081697
31	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	3.33203367
32	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	3.33203367
33	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	3.33203367
34	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	3.30760003
35	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	3.29193326
36	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	3.29193326
37	protein complex biogenesis (GO:0070271)	3.27476633
38	cytochrome complex assembly (GO:0017004)	3.26873010
39	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.25710923
40	pseudouridine synthesis (GO:0001522)	3.24736624
41	positive regulation of interleukin-17 production (GO:0032740)	3.24613016
42	regulation of immunoglobulin secretion (GO:0051023)	3.24540544
43	piRNA metabolic process (GO:0034587)	3.18201536
44	cullin deneddylation (GO:0010388)	3.17890010
45	mitochondrial respiratory chain complex assembly (GO:0033108)	3.16676061
46	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	3.16107765
47	negative regulation of ligase activity (GO:0051352)	3.16107765
48	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.13177181
49	signal transduction involved in DNA integrity checkpoint (GO:0072401)	3.12651568
50	signal transduction involved in DNA damage checkpoint (GO:0072422)	3.12651568
51	peptidyl-histidine modification (GO:0018202)	3.12491340
52	signal transduction involved in cell cycle checkpoint (GO:0072395)	3.11860106
53	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	3.09934535
54	iron-sulfur cluster assembly (GO:0016226)	3.08932586
55	metallo-sulfur cluster assembly (GO:0031163)	3.08932586
56	positive regulation of defense response to virus by host (GO:0002230)	3.08815147
57	organelle disassembly (GO:1903008)	3.02661920
58	signal peptide processing (GO:0006465)	3.00433160
59	ribonucleoprotein complex disassembly (GO:0032988)	3.00429993
60	protein polyglutamylation (GO:0018095)	3.00166148
61	limb bud formation (GO:0060174)	2.98728275
62	positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)	2.97956083
63	maturation of 5.8S rRNA (GO:0000460)	2.97244643
64	DNA double-strand break processing (GO:0000729)	2.93983402
65	tRNA processing (GO:0008033)	2.92357229
66	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.91132829
67	NADH dehydrogenase complex assembly (GO:0010257)	2.91132829
68	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.91132829
69	interferon-gamma production (GO:0032609)	2.88776443
70	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.84859215
71	behavioral response to nicotine (GO:0035095)	2.82829824
72	regulation of memory T cell differentiation (GO:0043380)	2.80359958
73	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	2.79692393
74	adenosine metabolic process (GO:0046085)	2.78426582
75	respiratory electron transport chain (GO:0022904)	2.78322077
76	electron transport chain (GO:0022900)	2.78073487
77	ribosomal large subunit biogenesis (GO:0042273)	2.77821114
78	regulation of isotype switching to IgG isotypes (GO:0048302)	2.73204498
79	ribosome assembly (GO:0042255)	2.72322350
80	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:	2.71768792
81	mitochondrial RNA metabolic process (GO:0000959)	2.71110699
82	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	2.70348953
83	positive regulation of ligase activity (GO:0051351)	2.70060635
84	negative regulation of B cell apoptotic process (GO:0002903)	2.65432048
85	intracellular protein transmembrane import (GO:0044743)	2.65410416
86	positive regulation of T-helper 1 type immune response (GO:0002827)	2.62701617
87	rRNA processing (GO:0006364)	2.61159907
88	tRNA metabolic process (GO:0006399)	2.60176587
89	rRNA metabolic process (GO:0016072)	2.59741771
90	regulation of immune response to tumor cell (GO:0002837)	2.56444945
91	regulation of response to tumor cell (GO:0002834)	2.56444945
92	positive regulation of response to tumor cell (GO:0002836)	2.56444945
93	positive regulation of immune response to tumor cell (GO:0002839)	2.56444945
94	tRNA modification (GO:0006400)	2.56338218
95	DNA catabolic process, exonucleolytic (GO:0000738)	2.54027365
96	kynurenine metabolic process (GO:0070189)	2.52915901
97	positive regulation of cell cycle arrest (GO:0071158)	2.51702252
98	antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)	2.50834994
99	protein localization to mitochondrion (GO:0070585)	2.50061889
100	positive regulation of prostaglandin secretion (GO:0032308)	2.49734375

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.44154929
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.40349125
3	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.56217139
4	ZNF274_21170338_ChIP-Seq_K562_Hela	3.17842141
5	VDR_22108803_ChIP-Seq_LS180_Human	3.12954921
6	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.92165645
7	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.83805766
8	VDR_23849224_ChIP-Seq_CD4+_Human	2.65214264
9	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.63582652
10	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.50387129
11	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.39613143
12	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.35611725
13	ELK1_19687146_ChIP-ChIP_HELA_Human	2.27771646
14	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.22462270
15	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.21116239
16	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.21009940
17	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.20854880
18	TAF15_26573619_Chip-Seq_HEK293_Human	2.11358702
19	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.06857112
20	EWS_26573619_Chip-Seq_HEK293_Human	2.04376047
21	FOXP3_21729870_ChIP-Seq_TREG_Human	2.01797624
22	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.00512648
23	IGF1R_20145208_ChIP-Seq_DFB_Human	1.88175338
24	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.87045340
25	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.82151072
26	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.79485311
27	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.77988195
28	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.77812288
29	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.75065835
30	FUS_26573619_Chip-Seq_HEK293_Human	1.62204000
31	P300_19829295_ChIP-Seq_ESCs_Human	1.60213449
32	MYC_18940864_ChIP-ChIP_HL60_Human	1.59971580
33	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.59736481
34	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.58242312
35	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.54613816
36	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.49656975
37	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.45616127
38	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.45146795
39	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.44785536
40	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.43619816
41	ER_23166858_ChIP-Seq_MCF-7_Human	1.41115239
42	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.39975093
43	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.39114925
44	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.38193111
45	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.36940053
46	TP53_22573176_ChIP-Seq_HFKS_Human	1.35692193
47	IRF1_19129219_ChIP-ChIP_H3396_Human	1.35199861
48	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.35177523
49	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.34440822
50	SOX2_19829295_ChIP-Seq_ESCs_Human	1.33913183
51	NANOG_19829295_ChIP-Seq_ESCs_Human	1.33913183
52	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.33672302
53	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.33541794
54	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.33341588
55	GBX2_23144817_ChIP-Seq_PC3_Human	1.31377380
56	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.30906046
57	DCP1A_22483619_ChIP-Seq_HELA_Human	1.29896822
58	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.28726121
59	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.25145733
60	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.22726310
61	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.22726310
62	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.21719821
63	AR_20517297_ChIP-Seq_VCAP_Human	1.20985981
64	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.19522613
65	GABP_19822575_ChIP-Seq_HepG2_Human	1.14831528
66	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.09700291
67	TTF2_22483619_ChIP-Seq_HELA_Human	1.08809820
68	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.07884496
69	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.06701872
70	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.06278091
71	GATA1_22025678_ChIP-Seq_K562_Human	1.05932019
72	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.05579913
73	CBP_20019798_ChIP-Seq_JUKART_Human	1.05579913
74	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.04823643
75	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.03565741
76	GATA3_26560356_Chip-Seq_TH2_Human	1.03507495
77	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.02159803
78	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.01876553
79	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.01048990
80	HOXB7_26014856_ChIP-Seq_BT474_Human	0.97826236
81	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.97589046
82	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.96846856
83	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.96541771
84	E2F4_17652178_ChIP-ChIP_JURKAT_Human	0.96081851
85	NCOR_22424771_ChIP-Seq_293T_Human	0.95875479
86	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	0.95129892
87	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.94846185
88	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.94265432
89	BCAT_22108803_ChIP-Seq_LS180_Human	0.94262162
90	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.90715627
91	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.90617845
92	RBPJ_21746931_ChIP-Seq_IB4_Human	0.90497076
93	CDX2_22108803_ChIP-Seq_LS180_Human	0.89587732
94	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.89088267
95	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.89063425
96	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.88215094
97	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.88206197
98	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.87497255
99	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.87044964
100	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.86983582

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003136_yellow_coat_color	3.44472721
2	MP0002102_abnormal_ear_morphology	2.70998927
3	MP0008877_abnormal_DNA_methylation	2.67850048
4	MP0005671_abnormal_response_to	2.60856901
5	MP0005379_endocrine/exocrine_gland_phen	2.52312167
6	MP0004147_increased_porphyrin_level	2.48981185
7	MP0001835_abnormal_antigen_presentation	2.42998883
8	MP0002163_abnormal_gland_morphology	2.39757019
9	MP0006072_abnormal_retinal_apoptosis	2.37652432
10	MP0006292_abnormal_olfactory_placode	2.25818432
11	MP0008875_abnormal_xenobiotic_pharmacok	2.24434879
12	MP0003195_calcinosis	2.22142242
13	MP0004142_abnormal_muscle_tone	2.21253408
14	MP0008872_abnormal_physiological_respon	2.08386426
15	MP0003786_premature_aging	2.07563115
16	MP0001986_abnormal_taste_sensitivity	2.07350368
17	MP0000566_synostosis	2.02462241
18	MP0005645_abnormal_hypothalamus_physiol	1.95372127
19	MP0008058_abnormal_DNA_repair	1.93898528
20	MP0009785_altered_susceptibility_to	1.90534478
21	MP0005670_abnormal_white_adipose	1.84414251
22	MP0005084_abnormal_gallbladder_morpholo	1.81067798
23	MP0002282_abnormal_trachea_morphology	1.77453731
24	MP0000372_irregular_coat_pigmentation	1.67464676
25	MP0005551_abnormal_eye_electrophysiolog	1.65108584
26	MP0000685_abnormal_immune_system	1.58720503
27	MP0002277_abnormal_respiratory_mucosa	1.56989463
28	MP0001529_abnormal_vocalization	1.55776548
29	MP0002837_dystrophic_cardiac_calcinosis	1.52108182
30	MP0002876_abnormal_thyroid_physiology	1.49854399
31	MP0004885_abnormal_endolymph	1.44842403
32	MP0001485_abnormal_pinna_reflex	1.44426332
33	MP0006036_abnormal_mitochondrial_physio	1.43357197
34	MP0002148_abnormal_hypersensitivity_rea	1.42588596
35	MP0001853_heart_inflammation	1.40828768
36	MP0001968_abnormal_touch/_nociception	1.38984089
37	MP0004145_abnormal_muscle_electrophysio	1.38936885
38	MP0002138_abnormal_hepatobiliary_system	1.38362641
39	MP0003718_maternal_effect	1.34685384
40	MP0005646_abnormal_pituitary_gland	1.33866975
41	MP0000465_gastrointestinal_hemorrhage	1.31281824
42	MP0001873_stomach_inflammation	1.29068217
43	MP0001790_abnormal_immune_system	1.28439721
44	MP0005387_immune_system_phenotype	1.28439721
45	MP0001501_abnormal_sleep_pattern	1.27467532
46	MP0005075_abnormal_melanosome_morpholog	1.23748060
47	MP0009764_decreased_sensitivity_to	1.21935727
48	MP0002736_abnormal_nociception_after	1.21563194
49	MP0005253_abnormal_eye_physiology	1.19307920
50	MP0006035_abnormal_mitochondrial_morpho	1.19166500
51	MP0001905_abnormal_dopamine_level	1.15640071
52	MP0001800_abnormal_humoral_immune	1.13309805
53	MP0005167_abnormal_blood-brain_barrier	1.11281405
54	MP0004957_abnormal_blastocyst_morpholog	1.07587049
55	MP0002272_abnormal_nervous_system	1.06349392
56	MP0001984_abnormal_olfaction	1.05945964
57	MP0002938_white_spotting	1.05164075
58	MP0005377_hearing/vestibular/ear_phenot	1.04248171
59	MP0003878_abnormal_ear_physiology	1.04248171
60	MP0000647_abnormal_sebaceous_gland	1.00724872
61	MP0003567_abnormal_fetal_cardiomyocyte	0.99505465
62	MP0003011_delayed_dark_adaptation	0.98627596
63	MP0003724_increased_susceptibility_to	0.98534582
64	MP0002006_tumorigenesis	0.98464733
65	MP0002733_abnormal_thermal_nociception	0.96527418
66	MP0002723_abnormal_immune_serum	0.95596131
67	MP0003787_abnormal_imprinting	0.94333714
68	MP0001293_anophthalmia	0.93571348
69	MP0000631_abnormal_neuroendocrine_gland	0.93065975
70	MP0003186_abnormal_redox_activity	0.92686564
71	MP0002166_altered_tumor_susceptibility	0.92163632
72	MP0003806_abnormal_nucleotide_metabolis	0.91962168
73	MP0008995_early_reproductive_senescence	0.89689405
74	MP0005389_reproductive_system_phenotype	0.88860477
75	MP0001919_abnormal_reproductive_system	0.88206621
76	MP0004782_abnormal_surfactant_physiolog	0.85885851
77	MP0005000_abnormal_immune_tolerance	0.85772791
78	MP0009745_abnormal_behavioral_response	0.85332339
79	MP0003880_abnormal_central_pattern	0.84266297
80	MP0002693_abnormal_pancreas_physiology	0.82661258
81	MP0008873_increased_physiological_sensi	0.81542605
82	MP0002405_respiratory_system_inflammati	0.79900178
83	MP0004215_abnormal_myocardial_fiber	0.79442912
84	MP0003763_abnormal_thymus_physiology	0.78673043
85	MP0009333_abnormal_splenocyte_physiolog	0.78078820
86	MP0002452_abnormal_antigen_presenting	0.78065443
87	MP0009046_muscle_twitch	0.77818110
88	MP0005332_abnormal_amino_acid	0.77565470
89	MP0000613_abnormal_salivary_gland	0.74194759
90	MP0001486_abnormal_startle_reflex	0.74156981
91	MP0010155_abnormal_intestine_physiology	0.73814131
92	MP0004134_abnormal_chest_morphology	0.73381652
93	MP0009780_abnormal_chondrocyte_physiolo	0.72614908
94	MP0001819_abnormal_immune_cell	0.71293264
95	MP0002420_abnormal_adaptive_immunity	0.70756308
96	MP0001970_abnormal_pain_threshold	0.70579779
97	MP0008007_abnormal_cellular_replicative	0.70521085
98	MP0001661_extended_life_span	0.68089091
99	MP0003866_abnormal_defecation	0.67945527
100	MP0009697_abnormal_copulation	0.67871527

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Increased hepatocellular lipid droplets (HP:0006565)	3.83820773
2	Lipid accumulation in hepatocytes (HP:0006561)	3.66977921
3	Congenital, generalized hypertrichosis (HP:0004540)	3.57898929
4	3-Methylglutaconic aciduria (HP:0003535)	3.34775297
5	Increased CSF lactate (HP:0002490)	3.30206782
6	Mitochondrial inheritance (HP:0001427)	3.25202830
7	Acute necrotizing encephalopathy (HP:0006965)	3.20893392
8	IgG deficiency (HP:0004315)	3.19876505
9	Abnormality of the labia minora (HP:0012880)	3.10575715
10	Conical tooth (HP:0000698)	3.01988071
11	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.87550508
12	Abnormality of alanine metabolism (HP:0010916)	2.87550508
13	Hyperalaninemia (HP:0003348)	2.87550508
14	Abolished electroretinogram (ERG) (HP:0000550)	2.83052520
15	Progressive macrocephaly (HP:0004481)	2.79614848
16	Increased serum lactate (HP:0002151)	2.77903553
17	Abnormal mitochondria in muscle tissue (HP:0008316)	2.76430136
18	Methylmalonic acidemia (HP:0002912)	2.75930659
19	Abnormality of the pons (HP:0007361)	2.72555457
20	Large for gestational age (HP:0001520)	2.70857375
21	Abnormality of the middle phalanges of the toes (HP:0010183)	2.70488622
22	Acute encephalopathy (HP:0006846)	2.67309423
23	Congenital stationary night blindness (HP:0007642)	2.64520320
24	Renal Fanconi syndrome (HP:0001994)	2.61456759
25	Stenosis of the external auditory canal (HP:0000402)	2.57969025
26	Stomatitis (HP:0010280)	2.51891843
27	Hepatocellular necrosis (HP:0001404)	2.50574826
28	Exertional dyspnea (HP:0002875)	2.49583779
29	Abnormality of midbrain morphology (HP:0002418)	2.48496140
30	Molar tooth sign on MRI (HP:0002419)	2.48496140
31	Stomach cancer (HP:0012126)	2.45987672
32	Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)	2.45478778
33	Abnormality of the phalanges of the 2nd finger (HP:0009541)	2.41380309
34	True hermaphroditism (HP:0010459)	2.39208786
35	Recurrent cutaneous fungal infections (HP:0011370)	2.39097541
36	Chronic mucocutaneous candidiasis (HP:0002728)	2.39097541
37	Increased intramyocellular lipid droplets (HP:0012240)	2.37586008
38	Constricted visual fields (HP:0001133)	2.32751025
39	Nephronophthisis (HP:0000090)	2.32647193
40	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.32046394
41	Aplasia/hypoplasia of the uterus (HP:0008684)	2.30997843
42	Hepatic necrosis (HP:0002605)	2.30407045
43	Megalencephaly (HP:0001355)	2.29916550
44	Type II lissencephaly (HP:0007260)	2.29844111
45	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.29663173
46	Gastrointestinal atresia (HP:0002589)	2.29157473
47	Elevated erythrocyte sedimentation rate (HP:0003565)	2.28025601
48	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.26700219
49	Optic disc pallor (HP:0000543)	2.25192652
50	Partial duplication of thumb phalanx (HP:0009944)	2.24777962
51	Bilateral microphthalmos (HP:0007633)	2.22973274
52	Pendular nystagmus (HP:0012043)	2.21058908
53	Methylmalonic aciduria (HP:0012120)	2.18413347
54	Hypoplasia of the pons (HP:0012110)	2.17250076
55	Abnormality of the anterior horn cell (HP:0006802)	2.16942020
56	Degeneration of anterior horn cells (HP:0002398)	2.16942020
57	Lactic acidosis (HP:0003128)	2.16853499
58	Severe combined immunodeficiency (HP:0004430)	2.12107590
59	Pancreatic cysts (HP:0001737)	2.11061854
60	Dyschromatopsia (HP:0007641)	2.09340741
61	Cerebral edema (HP:0002181)	2.05708788
62	Esophageal atresia (HP:0002032)	2.03334818
63	Abnormal rod and cone electroretinograms (HP:0008323)	2.03254122
64	Hypoplasia of the uterus (HP:0000013)	2.02021004
65	Abnormality of the renal medulla (HP:0100957)	1.98595622
66	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.98467648
67	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.98467648
68	Increased muscle lipid content (HP:0009058)	1.95271733
69	Abnormality of the renal cortex (HP:0011035)	1.94704572
70	Glycosuria (HP:0003076)	1.93427420
71	Abnormality of urine glucose concentration (HP:0011016)	1.93427420
72	Absent septum pellucidum (HP:0001331)	1.92830561
73	Aplasia involving bones of the extremities (HP:0009825)	1.92377411
74	Aplasia involving bones of the upper limbs (HP:0009823)	1.92377411
75	Aplasia of the phalanges of the hand (HP:0009802)	1.92377411
76	Type 2 muscle fiber atrophy (HP:0003554)	1.91924015
77	Lethargy (HP:0001254)	1.90871886
78	Attenuation of retinal blood vessels (HP:0007843)	1.90842694
79	Pancreatic fibrosis (HP:0100732)	1.89159695
80	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.87688633
81	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.87215525
82	Abnormality of the vitamin B12 metabolism (HP:0004341)	1.87151917
83	Abnormality of vitamin B metabolism (HP:0004340)	1.83861686
84	Thyroiditis (HP:0100646)	1.82829885
85	Split foot (HP:0001839)	1.80049826
86	Partial duplication of the phalanx of hand (HP:0009999)	1.79941925
87	Respiratory difficulties (HP:0002880)	1.79042773
88	Aplasia/Hypoplasia of the hallux (HP:0008362)	1.78798493
89	Medial flaring of the eyebrow (HP:0010747)	1.78396360
90	Increased serum pyruvate (HP:0003542)	1.77614186
91	Tongue fasciculations (HP:0001308)	1.75491703
92	Chronic otitis media (HP:0000389)	1.75085041
93	Retinal dysplasia (HP:0007973)	1.74109525
94	Inability to walk (HP:0002540)	1.73670355
95	Abnormality of serum amino acid levels (HP:0003112)	1.73650140
96	Brittle hair (HP:0002299)	1.72407747
97	Leukodystrophy (HP:0002415)	1.71195005
98	Supernumerary bones of the axial skeleton (HP:0009144)	1.70865067
99	Abnormality of T cell number (HP:0011839)	1.70571348
100	Renal cortical cysts (HP:0000803)	1.67637790

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TSSK6	3.78824512
2	TIE1	3.52793188
3	NUAK1	3.09807614
4	TXK	3.09147502
5	EIF2AK3	2.84664319
6	MST4	2.81521291
7	PINK1	2.80042931
8	MAP4K2	2.64020963
9	NEK1	2.27597298
10	FGFR2	2.20143196
11	ADRBK2	2.15929783
12	VRK2	2.10087832
13	ZAK	2.06314162
14	GRK1	2.05690537
15	BMPR1B	1.98564490
16	TLK1	1.89869571
17	TEC	1.88321677
18	EIF2AK1	1.87380251
19	STK16	1.71481287
20	VRK1	1.68526530
21	MAP3K12	1.68417298
22	TAOK3	1.67892331
23	FRK	1.58569308
24	NME1	1.50858585
25	PLK3	1.50824141
26	SRPK1	1.48348583
27	EIF2AK2	1.29202726
28	WNK4	1.27676424
29	BCKDK	1.27181718
30	CASK	1.23436312
31	CSNK1G2	1.19522909
32	WNK3	1.12622410
33	TAF1	1.10370649
34	LIMK1	1.08144436
35	KIT	1.05057366
36	MAP2K6	1.04238289
37	PLK2	1.03205554
38	CSNK1G3	1.02489280
39	CSNK1G1	1.01948648
40	IKBKB	1.01448245
41	MKNK1	1.00918124
42	IKBKE	1.00167586
43	TRIM28	0.99946926
44	FGFR1	0.98401078
45	PHKG2	0.97151317
46	PHKG1	0.97151317
47	PASK	0.95212762
48	BCR	0.94527185
49	MAP3K14	0.93972418
50	CSNK1A1L	0.89560536
51	INSRR	0.88124280
52	PLK4	0.86951049
53	TGFBR1	0.85341543
54	BUB1	0.84132201
55	OXSR1	0.83186092
56	KDR	0.78796958
57	MAPKAPK5	0.76999349
58	ITK	0.71797823
59	MKNK2	0.70621048
60	STK38L	0.64956812
61	CCNB1	0.64246742
62	RPS6KA5	0.63683615
63	CDK8	0.61218905
64	DYRK2	0.57744485
65	MYLK	0.56366735
66	ADRBK1	0.54187679
67	PRKCE	0.51578238
68	PAK4	0.51542128
69	FES	0.49568758
70	ACVR1B	0.49477749
71	GRK6	0.48086455
72	IGF1R	0.47604725
73	MUSK	0.45737228
74	PIK3CA	0.45081394
75	PRKCG	0.45023380
76	DAPK1	0.43322455
77	EPHA4	0.42518868
78	PAK3	0.42052284
79	PRKCQ	0.41886416
80	TESK2	0.41386089
81	MAP4K1	0.39673577
82	CSF1R	0.37120049
83	PNCK	0.34752366
84	SYK	0.34156407
85	CSNK2A1	0.33673555
86	PLK1	0.33318007
87	LCK	0.33102596
88	CSNK2A2	0.33043892
89	PRKG1	0.31772224
90	EGFR	0.31188948
91	FGFR3	0.30987824
92	LYN	0.29696390
93	MINK1	0.29569392
94	MAPK13	0.28406635
95	CAMKK2	0.27193995
96	TBK1	0.26797027
97	PRKCA	0.26587094
98	FER	0.26411464
99	CHUK	0.25420169
100	CSNK1A1	0.23976246

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	4.73091278
2	Protein export_Homo sapiens_hsa03060	3.10272218
3	Asthma_Homo sapiens_hsa05310	3.06080101
4	Oxidative phosphorylation_Homo sapiens_hsa00190	2.99080770
5	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.76050562
6	Type I diabetes mellitus_Homo sapiens_hsa04940	2.61031073
7	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	2.50252282
8	RNA polymerase_Homo sapiens_hsa03020	2.47564130
9	Parkinsons disease_Homo sapiens_hsa05012	2.47273709
10	Allograft rejection_Homo sapiens_hsa05330	2.44916051
11	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.36683149
12	Graft-versus-host disease_Homo sapiens_hsa05332	2.34366387
13	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.19510181
14	Basal transcription factors_Homo sapiens_hsa03022	1.97104462
15	Primary immunodeficiency_Homo sapiens_hsa05340	1.71052570
16	Ribosome_Homo sapiens_hsa03010	1.65269079
17	RNA degradation_Homo sapiens_hsa03018	1.62040909
18	Phototransduction_Homo sapiens_hsa04744	1.61924300
19	Antigen processing and presentation_Homo sapiens_hsa04612	1.61602158
20	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.58876598
21	Propanoate metabolism_Homo sapiens_hsa00640	1.54571220
22	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.47896061
23	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.47327339
24	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.47102597
25	Homologous recombination_Homo sapiens_hsa03440	1.43882821
26	Alzheimers disease_Homo sapiens_hsa05010	1.43876000
27	Spliceosome_Homo sapiens_hsa03040	1.41299724
28	Huntingtons disease_Homo sapiens_hsa05016	1.38997739
29	Caffeine metabolism_Homo sapiens_hsa00232	1.33400789
30	Rheumatoid arthritis_Homo sapiens_hsa05323	1.29812005
31	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.29472061
32	Regulation of autophagy_Homo sapiens_hsa04140	1.27542989
33	Non-homologous end-joining_Homo sapiens_hsa03450	1.27346770
34	Sulfur metabolism_Homo sapiens_hsa00920	1.24170906
35	One carbon pool by folate_Homo sapiens_hsa00670	1.22554016
36	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.21342698
37	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.20088513
38	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.15050582
39	Linoleic acid metabolism_Homo sapiens_hsa00591	1.14418528
40	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.11666441
41	Butanoate metabolism_Homo sapiens_hsa00650	1.10123910
42	Pyrimidine metabolism_Homo sapiens_hsa00240	1.08615929
43	Collecting duct acid secretion_Homo sapiens_hsa04966	1.04589330
44	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.03778499
45	Cardiac muscle contraction_Homo sapiens_hsa04260	1.02892096
46	RNA transport_Homo sapiens_hsa03013	1.01396195
47	Steroid biosynthesis_Homo sapiens_hsa00100	1.01056389
48	Purine metabolism_Homo sapiens_hsa00230	0.97129456
49	Nucleotide excision repair_Homo sapiens_hsa03420	0.96618157
50	Selenocompound metabolism_Homo sapiens_hsa00450	0.96417927
51	Tryptophan metabolism_Homo sapiens_hsa00380	0.91526677
52	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.90672065
53	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.90061882
54	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.89144058
55	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.88326013
56	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.86696637
57	Peroxisome_Homo sapiens_hsa04146	0.86336811
58	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.84571532
59	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.83018696
60	Base excision repair_Homo sapiens_hsa03410	0.82553888
61	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.80007359
62	Nitrogen metabolism_Homo sapiens_hsa00910	0.77682602
63	Ether lipid metabolism_Homo sapiens_hsa00565	0.72955182
64	Fanconi anemia pathway_Homo sapiens_hsa03460	0.72166890
65	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.69290174
66	Mismatch repair_Homo sapiens_hsa03430	0.66597173
67	Taste transduction_Homo sapiens_hsa04742	0.60045120
68	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.56788864
69	beta-Alanine metabolism_Homo sapiens_hsa00410	0.55579578
70	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.53832617
71	Legionellosis_Homo sapiens_hsa05134	0.53773827
72	Metabolic pathways_Homo sapiens_hsa01100	0.52342477
73	Chemical carcinogenesis_Homo sapiens_hsa05204	0.48349850
74	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.48047936
75	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.47321385
76	Folate biosynthesis_Homo sapiens_hsa00790	0.46272340
77	Pyruvate metabolism_Homo sapiens_hsa00620	0.45775959
78	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.43596057
79	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.42887131
80	Fatty acid elongation_Homo sapiens_hsa00062	0.42673282
81	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.41438655
82	Viral myocarditis_Homo sapiens_hsa05416	0.40624623
83	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.39375999
84	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.37130932
85	Retinol metabolism_Homo sapiens_hsa00830	0.36774952
86	Olfactory transduction_Homo sapiens_hsa04740	0.36750909
87	Nicotine addiction_Homo sapiens_hsa05033	0.36563600
88	Measles_Homo sapiens_hsa05162	0.36275404
89	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.32685195
90	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.32284529
91	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.31705519
92	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.31034480
93	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.30753366
94	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.30012407
95	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.25786805
96	Mineral absorption_Homo sapiens_hsa04978	0.24881731
97	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.22273359
98	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.22208512
99	Circadian rhythm_Homo sapiens_hsa04710	0.20767713
100	Sulfur relay system_Homo sapiens_hsa04122	0.20175194

DNAJA1P3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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