DNAJA2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the evolutionarily conserved DNAJ/HSP40 family of proteins, which regulate molecular chaperone activity by stimulating ATPase activity. DNAJ proteins may have up to 3 distinct domains: a conserved 70-amino acid J domain, usually at the N terminus; a glycine/phenylalanine (G/F)-rich region; and a cysteine-rich domain containing 4 motifs resembling a zinc finger domain. The product of this gene works as a cochaperone of Hsp70s in protein folding and mitochondrial protein import in vitro. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)4.93138271
2purine nucleobase biosynthetic process (GO:0009113)4.86721781
3IMP biosynthetic process (GO:0006188)4.75905791
4regulation of translational termination (GO:0006449)4.74419287
5DNA double-strand break processing (GO:0000729)4.68947241
6nucleobase biosynthetic process (GO:0046112)4.67670218
7IMP metabolic process (GO:0046040)4.64325667
8mitotic metaphase plate congression (GO:0007080)4.52705678
9proteasome assembly (GO:0043248)4.41353062
10ribosome assembly (GO:0042255)4.40281662
11formation of translation preinitiation complex (GO:0001731)4.39964780
12nuclear pore organization (GO:0006999)4.33934238
13establishment of integrated proviral latency (GO:0075713)4.28606292
14mitotic nuclear envelope disassembly (GO:0007077)4.23879616
15folic acid-containing compound biosynthetic process (GO:0009396)4.18408587
16nuclear pore complex assembly (GO:0051292)4.17830324
17DNA replication initiation (GO:0006270)4.13763615
18nuclear envelope disassembly (GO:0051081)4.12311440
19membrane disassembly (GO:0030397)4.12311440
20cullin deneddylation (GO:0010388)4.04111703
21regulation of spindle organization (GO:0090224)4.00003169
22mitotic chromosome condensation (GO:0007076)3.99009320
23DNA replication checkpoint (GO:0000076)3.98012787
24ribosome biogenesis (GO:0042254)3.89378763
25DNA strand elongation involved in DNA replication (GO:0006271)3.88011175
26protein localization to kinetochore (GO:0034501)3.80305049
27regulation of helicase activity (GO:0051095)3.72126910
28non-recombinational repair (GO:0000726)3.68729402
29double-strand break repair via nonhomologous end joining (GO:0006303)3.68729402
30metaphase plate congression (GO:0051310)3.68020868
31protein deneddylation (GO:0000338)3.65789445
32somatic hypermutation of immunoglobulin genes (GO:0016446)3.63775328
33somatic diversification of immune receptors via somatic mutation (GO:0002566)3.63775328
34DNA strand elongation (GO:0022616)3.59199670
35folic acid metabolic process (GO:0046655)3.57423184
36negative regulation of DNA-dependent DNA replication (GO:2000104)3.54960667
37DNA damage response, detection of DNA damage (GO:0042769)3.52994928
38regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.50347831
39negative regulation of DNA recombination (GO:0045910)3.42757416
40DNA replication-dependent nucleosome assembly (GO:0006335)3.42739620
41DNA replication-dependent nucleosome organization (GO:0034723)3.42739620
42regulation of mitotic spindle organization (GO:0060236)3.41783856
43nuclear envelope organization (GO:0006998)3.32930907
44telomere maintenance via telomerase (GO:0007004)3.31084903
45rRNA methylation (GO:0031167)3.31019655
46somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.26559128
47somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.26559128
48isotype switching (GO:0045190)3.26559128
49regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.24474892
50regulation of mitotic spindle checkpoint (GO:1903504)3.24474892
51regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.24406272
52rRNA modification (GO:0000154)3.23731255
53establishment of chromosome localization (GO:0051303)3.22440974
54lactate metabolic process (GO:0006089)3.20301078
55maturation of 5.8S rRNA (GO:0000460)3.19556399
56transcription from mitochondrial promoter (GO:0006390)3.18994680
57tRNA aminoacylation for protein translation (GO:0006418)3.18868611
58mitotic spindle assembly checkpoint (GO:0007094)3.18749313
59regulation of chromosome segregation (GO:0051983)3.18076184
60protein localization to chromosome, centromeric region (GO:0071459)3.17607094
61establishment of viral latency (GO:0019043)3.17381312
62tRNA aminoacylation (GO:0043039)3.17217451
63amino acid activation (GO:0043038)3.17217451
64monoubiquitinated protein deubiquitination (GO:0035520)3.16771097
65histone mRNA metabolic process (GO:0008334)3.15418968
66RNA-dependent DNA replication (GO:0006278)3.14882439
67negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.14800941
68negative regulation of sister chromatid segregation (GO:0033046)3.14800941
69negative regulation of mitotic sister chromatid separation (GO:2000816)3.14800941
70negative regulation of mitotic sister chromatid segregation (GO:0033048)3.14800941
71DNA catabolic process, exonucleolytic (GO:0000738)3.14109513
72negative regulation of chromosome segregation (GO:0051985)3.14039590
73mitochondrial RNA metabolic process (GO:0000959)3.12877134
74chaperone-mediated protein complex assembly (GO:0051131)3.10827787
75tricarboxylic acid cycle (GO:0006099)3.08818341
76spindle assembly checkpoint (GO:0071173)3.08815218
77maturation of SSU-rRNA (GO:0030490)3.07808550
78regulation of mitotic metaphase/anaphase transition (GO:0030071)3.07696953
79heterochromatin organization (GO:0070828)3.07268559
80mitotic spindle checkpoint (GO:0071174)3.06650239
81positive regulation of chromosome segregation (GO:0051984)3.06283962
82postreplication repair (GO:0006301)3.05169539
83mitotic sister chromatid cohesion (GO:0007064)3.04995863
84negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.04835124
85histone H2A monoubiquitination (GO:0035518)3.03871299
86regulation of centriole replication (GO:0046599)3.03753988
87mitotic G1 DNA damage checkpoint (GO:0031571)3.03488048
88regulation of centrosome cycle (GO:0046605)3.03221551
89anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.03203015
90regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.03094680
91regulation of RNA export from nucleus (GO:0046831)3.02758007
92spindle checkpoint (GO:0031577)3.02455470
93regulation of coenzyme metabolic process (GO:0051196)3.01969621
94regulation of cofactor metabolic process (GO:0051193)3.01969621
95negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.01784404
96negative regulation of ligase activity (GO:0051352)3.01784404
97peptidyl-arginine omega-N-methylation (GO:0035247)3.01071323
98regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.00157549
99regulation of sister chromatid cohesion (GO:0007063)2.99055881
100DNA ligation (GO:0006266)2.99039006
101chromatin remodeling at centromere (GO:0031055)2.95371249
102DNA duplex unwinding (GO:0032508)2.95154588
103positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.94981315
104regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.94475224
105DNA geometric change (GO:0032392)2.92915331
106pore complex assembly (GO:0046931)2.92759479
107attachment of spindle microtubules to kinetochore (GO:0008608)2.91398660
108cell cycle G1/S phase transition (GO:0044843)2.89133829
109G1/S transition of mitotic cell cycle (GO:0000082)2.89133829
110telomere maintenance via semi-conservative replication (GO:0032201)2.88550731
111CENP-A containing nucleosome assembly (GO:0034080)2.86635491
112DNA replication-independent nucleosome assembly (GO:0006336)2.85494152
113DNA replication-independent nucleosome organization (GO:0034724)2.85494152
114RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.84972620
115regulation of sister chromatid segregation (GO:0033045)2.84637015
116regulation of mitotic sister chromatid separation (GO:0010965)2.84637015
117regulation of mitotic sister chromatid segregation (GO:0033047)2.84637015
118spliceosomal snRNP assembly (GO:0000387)2.83704928
119positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.83354773
120negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.83225907
121translesion synthesis (GO:0019985)2.82534441
122regulation of cellular amino acid metabolic process (GO:0006521)2.82489145
123somatic recombination of immunoglobulin gene segments (GO:0016447)2.82011406
124regulation of acyl-CoA biosynthetic process (GO:0050812)2.80729463
125water-soluble vitamin biosynthetic process (GO:0042364)2.79038754
126ribonucleoprotein complex biogenesis (GO:0022613)2.78912809
127regulation of translational initiation (GO:0006446)2.78642219
128regulation of meiosis I (GO:0060631)2.78149534
129mitotic sister chromatid segregation (GO:0000070)2.77698508
130response to X-ray (GO:0010165)2.76865349
131negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.76674081
132peptidyl-arginine N-methylation (GO:0035246)2.76420500
133peptidyl-arginine methylation (GO:0018216)2.76420500
134histone exchange (GO:0043486)2.76124929
135protein localization to chromosome (GO:0034502)2.73793434
136protein neddylation (GO:0045116)2.72700227
137telomere maintenance via recombination (GO:0000722)2.71783781
138protein complex localization (GO:0031503)2.71562325
139regulation of DNA endoreduplication (GO:0032875)2.71091969
140positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.70866180
141positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.70866180
142positive regulation of mitotic sister chromatid separation (GO:1901970)2.70866180
143replication fork processing (GO:0031297)2.70822653
144negative regulation of mRNA metabolic process (GO:1903312)2.69576695
145regulation of translational fidelity (GO:0006450)2.69562830
146histone-serine phosphorylation (GO:0035404)2.69523071
147synaptonemal complex assembly (GO:0007130)2.68096322
148G1 DNA damage checkpoint (GO:0044783)2.66965735
149sister chromatid segregation (GO:0000819)2.66679893
150mitotic recombination (GO:0006312)2.66384210

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.73393264
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.56692510
3* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.28108097
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.75380364
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.18678009
6AR_21909140_ChIP-Seq_LNCAP_Human3.03050723
7* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.86946697
8EGR1_19374776_ChIP-ChIP_THP-1_Human2.86173890
9* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.71832258
10FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.70787623
11MYC_18358816_ChIP-ChIP_MESCs_Mouse2.65175989
12* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.59229416
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.55725118
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.48285221
15MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.39527539
16* GABP_17652178_ChIP-ChIP_JURKAT_Human2.37791915
17PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.33708982
18KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.27578643
19EST1_17652178_ChIP-ChIP_JURKAT_Human2.27100994
20XRN2_22483619_ChIP-Seq_HELA_Human2.22824651
21JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.22462937
22NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.20412515
23* ZFX_18555785_ChIP-Seq_MESCs_Mouse2.17780910
24* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.17685776
25MYCN_18555785_ChIP-Seq_MESCs_Mouse2.13254962
26E2F1_21310950_ChIP-Seq_MCF-7_Human1.99378215
27RBPJ_22232070_ChIP-Seq_NCS_Mouse1.99081474
28GABP_19822575_ChIP-Seq_HepG2_Human1.98104500
29DCP1A_22483619_ChIP-Seq_HELA_Human1.98004982
30VDR_23849224_ChIP-Seq_CD4+_Human1.96906746
31MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.96670710
32E2F1_18555785_ChIP-Seq_MESCs_Mouse1.94086476
33* MYC_22102868_ChIP-Seq_BL_Human1.90513929
34ZNF263_19887448_ChIP-Seq_K562_Human1.90372069
35ZNF274_21170338_ChIP-Seq_K562_Hela1.85717356
36EWS_26573619_Chip-Seq_HEK293_Human1.83498916
37E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.80768140
38POU3F2_20337985_ChIP-ChIP_501MEL_Human1.78905173
39STAT3_1855785_ChIP-Seq_MESCs_Mouse1.75957122
40FLI1_27457419_Chip-Seq_LIVER_Mouse1.74728953
41TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.72899247
42* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.71532618
43HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.69033246
44TTF2_22483619_ChIP-Seq_HELA_Human1.64206939
45POU5F1_16153702_ChIP-ChIP_HESCs_Human1.64068295
46FUS_26573619_Chip-Seq_HEK293_Human1.62952157
47NOTCH1_21737748_ChIP-Seq_TLL_Human1.60457800
48* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.60321380
49FOXP3_21729870_ChIP-Seq_TREG_Human1.57279886
50TAF15_26573619_Chip-Seq_HEK293_Human1.56359832
51VDR_22108803_ChIP-Seq_LS180_Human1.53121230
52POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.52752927
53KDM5A_27292631_Chip-Seq_BREAST_Human1.51506969
54POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.49381876
55ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.48084851
56FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.46406169
57TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.45968496
58NANOG_18555785_ChIP-Seq_MESCs_Mouse1.45046676
59NANOG_16153702_ChIP-ChIP_HESCs_Human1.44609570
60YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.44355231
61* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.42125031
62SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.41313614
63ELK1_19687146_ChIP-ChIP_HELA_Human1.39469778
64P300_19829295_ChIP-Seq_ESCs_Human1.38156322
65GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.37665462
66IGF1R_20145208_ChIP-Seq_DFB_Human1.37641549
67CIITA_25753668_ChIP-Seq_RAJI_Human1.37095682
68SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.36628416
69* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.36592332
70MYC_18940864_ChIP-ChIP_HL60_Human1.36332024
71ELF1_17652178_ChIP-ChIP_JURKAT_Human1.35201827
72THAP11_20581084_ChIP-Seq_MESCs_Mouse1.34955416
73CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.34603352
74ATF3_27146783_Chip-Seq_COLON_Human1.32249524
75DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.30663873
76* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.30566944
77ESR1_15608294_ChIP-ChIP_MCF-7_Human1.30166090
78TFEB_21752829_ChIP-Seq_HELA_Human1.27588236
79PCGF2_27294783_Chip-Seq_ESCs_Mouse1.24742528
80CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.24104244
81* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.23712856
82* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.22492508
83SOX2_16153702_ChIP-ChIP_HESCs_Human1.21117502
84CLOCK_20551151_ChIP-Seq_293T_Human1.20988598
85ZFP57_27257070_Chip-Seq_ESCs_Mouse1.20684388
86ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.20295760
87CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.19461879
88CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.16153267
89SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.14998531
90FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.14989964
91RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.14123234
92NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.13850184
93PADI4_21655091_ChIP-ChIP_MCF-7_Human1.12332511
94HOXB4_20404135_ChIP-ChIP_EML_Mouse1.11493335
95DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.09170851
96CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.08393484
97* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.06689758
98TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.06347811
99NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.05565065
100SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04432652
101ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.04280785
102PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.03024877
103YY1_21170310_ChIP-Seq_MESCs_Mouse1.02907926
104CHD1_26751641_Chip-Seq_LNCaP_Human1.02442159
105NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.01819268
106BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.00267851
107GBX2_23144817_ChIP-Seq_PC3_Human0.99762910
108AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.99691632
109PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.98203397
110PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.98129052
111HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.97893877
112* SOX17_20123909_ChIP-Seq_XEN_Mouse0.97824108
113GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97729983
114* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.97717222
115SOX2_18555785_ChIP-Seq_MESCs_Mouse0.96639605
116CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.95746143
117HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.95404206
118HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.95152925
119CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.94751541
120HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.94698814
121* SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.94377907
122HIF1A_21447827_ChIP-Seq_MCF-7_Human0.93893397
123SRF_21415370_ChIP-Seq_HL-1_Mouse0.91771259
124ERG_20887958_ChIP-Seq_HPC-7_Mouse0.91112899
125OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.90711376
126EZH2_27294783_Chip-Seq_NPCs_Mouse0.89072335
127MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.88006613
128WT1_19549856_ChIP-ChIP_CCG9911_Human0.87738801
129ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.87590751
130GATA4_21415370_ChIP-Seq_HL-1_Mouse0.86764921
131KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.85670324
132TCF3_18692474_ChIP-Seq_MEFs_Mouse0.85200507
133NANOG_21062744_ChIP-ChIP_HESCs_Human0.84916865
134OCT4_18692474_ChIP-Seq_MEFs_Mouse0.83923530
135TBX5_21415370_ChIP-Seq_HL-1_Mouse0.83667406
136SUZ12_27294783_Chip-Seq_NPCs_Mouse0.83261346
137NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.83202340
138SALL4_22934838_ChIP-ChIP_CD34+_Human0.82035922
139ELK1_22589737_ChIP-Seq_MCF10A_Human0.81240974
140TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.80850837
141MYB_21317192_ChIP-Seq_ERMYB_Mouse0.80622986
142POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.80242957
143IRF1_19129219_ChIP-ChIP_H3396_Human0.80129908
144EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.79537619
145HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.79354722
146SALL1_21062744_ChIP-ChIP_HESCs_Human0.79179000
147NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.78528152

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.44674917
2MP0004957_abnormal_blastocyst_morpholog4.16933130
3MP0010094_abnormal_chromosome_stability3.49952475
4MP0010352_gastrointestinal_tract_polyps3.31813432
5MP0003111_abnormal_nucleus_morphology3.31357318
6MP0003123_paternal_imprinting3.29055538
7MP0003077_abnormal_cell_cycle3.01090000
8MP0003646_muscle_fatigue2.99548310
9MP0002102_abnormal_ear_morphology2.93412313
10MP0001730_embryonic_growth_arrest2.74597961
11MP0004084_abnormal_cardiac_muscle2.64130580
12MP0003221_abnormal_cardiomyocyte_apopto2.58063383
13MP0003705_abnormal_hypodermis_morpholog2.48738739
14MP0008007_abnormal_cellular_replicative2.30665680
15MP0004233_abnormal_muscle_weight2.16699499
16MP0010234_abnormal_vibrissa_follicle2.16150462
17MP0008877_abnormal_DNA_methylation2.12051518
18MP0000750_abnormal_muscle_regeneration2.05604951
19MP0000350_abnormal_cell_proliferation2.01353596
20MP0010307_abnormal_tumor_latency1.99006814
21MP0008932_abnormal_embryonic_tissue1.98180267
22MP0008058_abnormal_DNA_repair1.92223682
23MP0008057_abnormal_DNA_replication1.92136801
24MP0001697_abnormal_embryo_size1.89404844
25MP0003195_calcinosis1.86416231
26MP0000751_myopathy1.85384564
27MP0003787_abnormal_imprinting1.82962698
28MP0001672_abnormal_embryogenesis/_devel1.82030980
29MP0005380_embryogenesis_phenotype1.82030980
30MP0003984_embryonic_growth_retardation1.81255096
31MP0004215_abnormal_myocardial_fiber1.80617590
32MP0009697_abnormal_copulation1.78376788
33MP0002088_abnormal_embryonic_growth/wei1.76583032
34MP0003567_abnormal_fetal_cardiomyocyte1.72521361
35MP0002396_abnormal_hematopoietic_system1.72267506
36MP0001529_abnormal_vocalization1.66877689
37MP0002269_muscular_atrophy1.66712099
38MP0003806_abnormal_nucleotide_metabolis1.62025280
39MP0004036_abnormal_muscle_relaxation1.61666012
40MP0001984_abnormal_olfaction1.61594402
41MP0002080_prenatal_lethality1.60855122
42MP0004087_abnormal_muscle_fiber1.53982111
43MP0002084_abnormal_developmental_patter1.53917936
44MP0004808_abnormal_hematopoietic_stem1.53336634
45MP0005330_cardiomyopathy1.52847067
46MP0000747_muscle_weakness1.52496458
47MP0001293_anophthalmia1.49231857
48MP0002086_abnormal_extraembryonic_tissu1.45192372
49MP0010030_abnormal_orbit_morphology1.43435698
50MP0002090_abnormal_vision1.40388321
51MP0000372_irregular_coat_pigmentation1.38592955
52MP0004197_abnormal_fetal_growth/weight/1.38268825
53MP0002938_white_spotting1.37291113
54MP0002085_abnormal_embryonic_tissue1.36423525
55MP0002751_abnormal_autonomic_nervous1.35954553
56MP0005076_abnormal_cell_differentiation1.33575346
57MP0003119_abnormal_digestive_system1.31862947
58MP0001188_hyperpigmentation1.30279790
59MP0002106_abnormal_muscle_physiology1.30121139
60MP0000749_muscle_degeneration1.29622162
61MP0006072_abnormal_retinal_apoptosis1.29081210
62MP0003122_maternal_imprinting1.27900648
63MP0010630_abnormal_cardiac_muscle1.24559963
64MP0003566_abnormal_cell_adhesion1.24546587
65MP0000647_abnormal_sebaceous_gland1.22370911
66MP0002877_abnormal_melanocyte_morpholog1.22311654
67MP0000733_abnormal_muscle_development1.21690322
68MP0003937_abnormal_limbs/digits/tail_de1.21567685
69MP0003786_premature_aging1.20916758
70MP0006036_abnormal_mitochondrial_physio1.20385182
71MP0003880_abnormal_central_pattern1.19853776
72MP0000537_abnormal_urethra_morphology1.18880467
73MP0002019_abnormal_tumor_incidence1.15121476
74MP0009703_decreased_birth_body1.12227005
75MP0002254_reproductive_system_inflammat1.11209596
76MP0005379_endocrine/exocrine_gland_phen1.10747678
77MP0000358_abnormal_cell_content/1.10412224
78MP0000313_abnormal_cell_death1.10144680
79MP0002837_dystrophic_cardiac_calcinosis1.09410192
80MP0002210_abnormal_sex_determination1.09129783
81MP0008789_abnormal_olfactory_epithelium1.08044662
82MP0002736_abnormal_nociception_after1.07498656
83MP0002233_abnormal_nose_morphology1.07025537
84MP0003718_maternal_effect1.06980494
85MP0001545_abnormal_hematopoietic_system1.05456842
86MP0005397_hematopoietic_system_phenotyp1.05456842
87MP0005187_abnormal_penis_morphology1.04616233
88MP0001544_abnormal_cardiovascular_syste1.03599768
89MP0005385_cardiovascular_system_phenoty1.03599768
90MP0005266_abnormal_metabolism1.02897714
91MP0000759_abnormal_skeletal_muscle1.00694428
92MP0001286_abnormal_eye_development0.96740625
93MP0004145_abnormal_muscle_electrophysio0.96222352
94MP0000516_abnormal_urinary_system0.96219710
95MP0005367_renal/urinary_system_phenotyp0.96219710
96MP0008775_abnormal_heart_ventricle0.95748424
97MP0000490_abnormal_crypts_of0.95584033
98MP0001177_atelectasis0.95271461
99MP0001145_abnormal_male_reproductive0.94224986
100MP0002234_abnormal_pharynx_morphology0.93968128
101MP0004270_analgesia0.93631075
102MP0002163_abnormal_gland_morphology0.91705475
103MP0005394_taste/olfaction_phenotype0.90668018
104MP0005499_abnormal_olfactory_system0.90668018
105MP0005395_other_phenotype0.90666082
106MP0005620_abnormal_muscle_contractility0.90254434
107MP0010678_abnormal_skin_adnexa0.90207664
108MP0005023_abnormal_wound_healing0.88740192
109MP0003121_genomic_imprinting0.88543536
110MP0006138_congestive_heart_failure0.87889109
111MP0009672_abnormal_birth_weight0.87794166
112MP0002697_abnormal_eye_size0.86991401
113MP0003890_abnormal_embryonic-extraembry0.85924703
114MP0003315_abnormal_perineum_morphology0.85029890
115MP0005253_abnormal_eye_physiology0.84400927
116MP0006054_spinal_hemorrhage0.83850382
117MP0002332_abnormal_exercise_endurance0.83588467
118MP0005369_muscle_phenotype0.83447611
119MP0005621_abnormal_cell_physiology0.81888507
120MP0002972_abnormal_cardiac_muscle0.81758191
121MP0003941_abnormal_skin_development0.81750945
122MP0004185_abnormal_adipocyte_glucose0.80898454
123MP0005384_cellular_phenotype0.80023837
124MP0000653_abnormal_sex_gland0.78959517
125MP0000266_abnormal_heart_morphology0.78522390
126MP0004484_altered_response_of0.75850122
127MP0006035_abnormal_mitochondrial_morpho0.74639975
128MP0003186_abnormal_redox_activity0.71735154
129MP0003137_abnormal_impulse_conducting0.71697226
130MP0005623_abnormal_meninges_morphology0.71422963
131MP0009053_abnormal_anal_canal0.68237515
132MP0001915_intracranial_hemorrhage0.68154966
133MP0001661_extended_life_span0.67869532
134MP0001929_abnormal_gametogenesis0.67142550
135MP0002796_impaired_skin_barrier0.65468185
136MP0009333_abnormal_splenocyte_physiolog0.65307441
137MP0002160_abnormal_reproductive_system0.65184828
138MP0010368_abnormal_lymphatic_system0.63921948
139MP0001299_abnormal_eye_distance/0.63461384
140MP0006276_abnormal_autonomic_nervous0.63183260
141MP0003755_abnormal_palate_morphology0.62825595
142MP0004133_heterotaxia0.62742579
143MP0005332_abnormal_amino_acid0.62426806
144MP0000427_abnormal_hair_cycle0.59616605
145MP0000858_altered_metastatic_potential0.59569189
146MP0005084_abnormal_gallbladder_morpholo0.59165603
147MP0000343_altered_response_to0.55865256

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the labia minora (HP:0012880)4.23599211
2Pelvic girdle muscle weakness (HP:0003749)4.09323319
3Shoulder girdle muscle weakness (HP:0003547)4.01467310
4Exercise-induced muscle cramps (HP:0003710)3.87221441
5Abnormality of the musculature of the pelvis (HP:0001469)3.61631221
6Abnormality of the hip-girdle musculature (HP:0001445)3.61631221
7Birth length less than 3rd percentile (HP:0003561)3.57697351
8Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.56328737
9Abnormality of alanine metabolism (HP:0010916)3.56328737
10Hyperalaninemia (HP:0003348)3.56328737
11Difficulty climbing stairs (HP:0003551)3.53208920
12Multiple enchondromatosis (HP:0005701)3.34346997
13Abnormality of methionine metabolism (HP:0010901)3.31850100
14Oral leukoplakia (HP:0002745)3.17430861
15Limb-girdle muscle atrophy (HP:0003797)2.95122491
16Rhabdomyolysis (HP:0003201)2.92745044
17Calcaneovalgus deformity (HP:0001848)2.92386496
18Degeneration of anterior horn cells (HP:0002398)2.92121834
19Abnormality of the anterior horn cell (HP:0006802)2.92121834
20Muscle fiber splitting (HP:0003555)2.89424489
21Selective tooth agenesis (HP:0001592)2.88560981
22Neoplasm of the adrenal gland (HP:0100631)2.80862485
23Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.79962239
24Ankle contracture (HP:0006466)2.79128431
25Myoglobinuria (HP:0002913)2.79017369
26Abnormality of aspartate family amino acid metabolism (HP:0010899)2.79004056
27Increased connective tissue (HP:0009025)2.76898654
28Abnormality of the calcaneus (HP:0008364)2.74959975
29Muscle fiber inclusion bodies (HP:0100299)2.73779971
30Abnormal lung lobation (HP:0002101)2.72312050
31Nephroblastoma (Wilms tumor) (HP:0002667)2.72128804
32Hypoglycemic coma (HP:0001325)2.70972690
33Abnormality of chromosome stability (HP:0003220)2.68653459
34Microretrognathia (HP:0000308)2.68608781
35Breast hypoplasia (HP:0003187)2.66356808
36Abnormality of serum amino acid levels (HP:0003112)2.65496519
37Ependymoma (HP:0002888)2.62527101
38Embryonal renal neoplasm (HP:0011794)2.62032360
39Pancreatic islet-cell hyperplasia (HP:0004510)2.61943718
40Deformed tarsal bones (HP:0008119)2.61813212
41Meckel diverticulum (HP:0002245)2.57593827
42Biliary tract neoplasm (HP:0100574)2.57332197
43Chromosomal breakage induced by crosslinking agents (HP:0003221)2.56121507
44Abnormality of the ileum (HP:0001549)2.46135014
45Abnormality of the preputium (HP:0100587)2.44672593
46Increased hepatocellular lipid droplets (HP:0006565)2.44028458
47Ulnar deviation of the wrist (HP:0003049)2.44018584
48Glioma (HP:0009733)2.44004133
49Methylmalonic acidemia (HP:0002912)2.43964349
50Protrusio acetabuli (HP:0003179)2.42615991
51Hypoglycemic seizures (HP:0002173)2.42447829
52Chromsome breakage (HP:0040012)2.42229526
53Nemaline bodies (HP:0003798)2.41751804
54Colon cancer (HP:0003003)2.40479254
55Acute encephalopathy (HP:0006846)2.39478223
56Hyperglycinemia (HP:0002154)2.37371967
57Limb-girdle muscle weakness (HP:0003325)2.37053350
58Abnormality of the astrocytes (HP:0100707)2.36449045
59Astrocytoma (HP:0009592)2.36449045
60Postnatal microcephaly (HP:0005484)2.36061441
61Trismus (HP:0000211)2.34299120
62Progressive muscle weakness (HP:0003323)2.33742829
63Acute necrotizing encephalopathy (HP:0006965)2.32814398
64Atrophy/Degeneration involving motor neurons (HP:0007373)2.32696596
65Cutaneous melanoma (HP:0012056)2.32209564
66Adenoma sebaceum (HP:0009720)2.31120642
67Angiofibromas (HP:0010615)2.31120642
68Facial hemangioma (HP:0000329)2.30818863
69Neoplasm of the rectum (HP:0100743)2.29285060
70Aplasia/Hypoplasia of the uvula (HP:0010293)2.27303466
71Hyperinsulinemic hypoglycemia (HP:0000825)2.27003556
72Distal arthrogryposis (HP:0005684)2.24622903
73Carpal bone hypoplasia (HP:0001498)2.23359799
74Volvulus (HP:0002580)2.22723057
75Breast carcinoma (HP:0003002)2.22390194
76Progressive macrocephaly (HP:0004481)2.21631189
77Deviation of the thumb (HP:0009603)2.20105668
78Proximal placement of thumb (HP:0009623)2.19512535
79Myopathic facies (HP:0002058)2.19460655
80Sensory axonal neuropathy (HP:0003390)2.17841021
81Spastic diplegia (HP:0001264)2.15112825
82Neoplasm of the pancreas (HP:0002894)2.14934085
83Small intestinal stenosis (HP:0012848)2.13277519
84Duodenal stenosis (HP:0100867)2.13277519
85Increased CSF lactate (HP:0002490)2.12697348
86Abnormality of serine family amino acid metabolism (HP:0010894)2.12655537
87Abnormality of glycine metabolism (HP:0010895)2.12655537
88Exercise-induced myalgia (HP:0003738)2.12114160
89Lipid accumulation in hepatocytes (HP:0006561)2.11225759
90Slender long bone (HP:0003100)2.11175241
91Neoplasm of the adrenal cortex (HP:0100641)2.10781478
92Premature ovarian failure (HP:0008209)2.09001729
93Intestinal atresia (HP:0011100)2.08008875
94Gonadotropin excess (HP:0000837)2.07262895
95Ventricular tachycardia (HP:0004756)2.06655999
96Rimmed vacuoles (HP:0003805)2.04179292
97Rough bone trabeculation (HP:0100670)2.02269009
98Abnormality of the duodenum (HP:0002246)2.01590306
99Cerebral edema (HP:0002181)2.01350884
100Abnormality of the lower motor neuron (HP:0002366)2.00359253
101Achilles tendon contracture (HP:0001771)2.00238394
102Cerebral hypomyelination (HP:0006808)1.99907027
103Cortical dysplasia (HP:0002539)1.98255870
104Sudden death (HP:0001699)1.97526224
105Bundle branch block (HP:0011710)1.95664206
106Hyperglycinuria (HP:0003108)1.94813138
107Megaloblastic anemia (HP:0001889)1.94157716
108Increased serum lactate (HP:0002151)1.94052016
109Rhabdomyosarcoma (HP:0002859)1.93992916
110Glossoptosis (HP:0000162)1.93487083
111Basal cell carcinoma (HP:0002671)1.93189707
112Abnormal mitochondria in muscle tissue (HP:0008316)1.93056653
113Ragged-red muscle fibers (HP:0003200)1.92136255
114Stenosis of the external auditory canal (HP:0000402)1.90920653
115Supernumerary spleens (HP:0009799)1.90527373
116Metaphyseal cupping (HP:0003021)1.88843227
117Neoplasm of the small intestine (HP:0100833)1.88213686
118Uterine neoplasm (HP:0010784)1.87959537
119Right ventricular cardiomyopathy (HP:0011663)1.87657043
120Increased density of long bones (HP:0006392)1.87189778
121Abnormal biliary tract morphology (HP:0012440)1.86863122
122Unsteady gait (HP:0002317)1.86629347
123Microvesicular hepatic steatosis (HP:0001414)1.86301172
124Progressive external ophthalmoplegia (HP:0000590)1.85689834
125Papillary thyroid carcinoma (HP:0002895)1.85623211
126Symptomatic seizures (HP:0011145)1.84508228
127Aplastic anemia (HP:0001915)1.84221717
128Ovarian neoplasm (HP:0100615)1.83470675
129Abnormal hair whorl (HP:0010721)1.83347849
130EMG: myopathic abnormalities (HP:0003458)1.83034648
131Hypothermia (HP:0002045)1.82828037
132Sloping forehead (HP:0000340)1.82163216
133Abnormality of the vitamin B12 metabolism (HP:0004341)1.81948926
134Patellar aplasia (HP:0006443)1.81020649
135Palpitations (HP:0001962)1.80895963
136Abnormality of the Achilles tendon (HP:0005109)1.80807021
137Abnormality of the pancreatic islet cells (HP:0006476)1.79612148
138Abnormality of endocrine pancreas physiology (HP:0012093)1.79612148
139Bifid tongue (HP:0010297)1.79564444
140Muscle fibrillation (HP:0010546)1.78658615
141Agnosia (HP:0010524)1.78642255
142Abnormality of vitamin B metabolism (HP:0004340)1.78156536
143Medulloblastoma (HP:0002885)1.77878857
144Reduced subcutaneous adipose tissue (HP:0003758)1.77554938
145Thyroid carcinoma (HP:0002890)1.77520064
146Annular pancreas (HP:0001734)1.76739925
147Entropion (HP:0000621)1.76503193
148Abnormality of glycolysis (HP:0004366)1.76319889
149Increased serum pyruvate (HP:0003542)1.76319889
150Lipoatrophy (HP:0100578)1.75524589
151Abnormality of the clitoris (HP:0000056)1.75215794
152Areflexia of lower limbs (HP:0002522)1.75129528
153Abnormality of the motor neurons (HP:0002450)1.74952517
154Abnormal neuron morphology (HP:0012757)1.74952517
155Abnormality of the calf musculature (HP:0001430)1.73883744
156Overlapping toe (HP:0001845)1.73573486
157Type 1 muscle fiber predominance (HP:0003803)1.71921272
158Hand muscle atrophy (HP:0009130)1.71708346
159Neoplasm of the colon (HP:0100273)1.71648509
160Aplasia/Hypoplasia of the patella (HP:0006498)1.71642091
161Calf muscle hypertrophy (HP:0008981)1.71425166
162Abnormality of sulfur amino acid metabolism (HP:0004339)1.70880772
163Distal upper limb amyotrophy (HP:0007149)1.70638799
164Upper limb amyotrophy (HP:0009129)1.70638799
165Atrioventricular block (HP:0001678)1.70071353
166CNS hypomyelination (HP:0003429)1.69476742
167Mitochondrial inheritance (HP:0001427)1.69190377
168Abnormality of homocysteine metabolism (HP:0010919)1.66908975
169Homocystinuria (HP:0002156)1.66908975
170Horseshoe kidney (HP:0000085)1.66892176
171Lactic acidosis (HP:0003128)1.66120943
172Poor suck (HP:0002033)1.65262654
173Hypoplastic female external genitalia (HP:0012815)1.64063546

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIM283.93959099
2NEK13.89333003
3CDC73.73991589
4WEE13.55765698
5MST43.19996035
6MKNK23.07236161
7BUB12.94131684
8EIF2AK12.86303120
9SCYL22.78221871
10ACVR1B2.64396734
11NEK22.55829895
12PKN22.41398482
13PDK32.33699545
14PDK42.33699545
15BCR2.25290209
16ERBB32.12301883
17WNK32.07031794
18TNIK2.05497081
19TSSK61.97686018
20RPS6KA41.94815804
21EEF2K1.94066245
22TTN1.94064677
23TAF11.91566990
24NUAK11.81868022
25LATS21.80242953
26TRIB31.78498582
27ZAK1.76645211
28TTK1.70972160
29BRSK21.70143154
30KSR21.69931273
31PLK21.54240647
32TGFBR11.51035089
33MAPKAPK31.49702737
34PLK11.48273773
35RPS6KB21.42009577
36VRK11.38084387
37MAP3K91.38065150
38SIK31.33947391
39BMPR1B1.32033646
40CCNB11.27787147
41KSR11.26080721
42MAP3K111.25455969
43VRK21.25264692
44EIF2AK31.25094868
45PDK21.22751862
46MAP3K51.22628832
47FLT31.21734523
48MAP3K81.20433311
49AURKB1.18327054
50RAF11.18227842
51CDK41.17897049
52PLK41.17819057
53CSNK1G11.14194934
54FRK1.12239086
55PLK31.08943886
56MKNK11.06038512
57ARAF1.05736106
58LATS11.04842561
59BRSK11.04443166
60PAK41.02221191
61STK391.00646273
62EIF2AK20.98948803
63CSNK1G30.96952203
64CSNK1G20.96894516
65CDK70.96652339
66STK160.96157810
67TAOK10.95337139
68ATR0.95084294
69CSNK1A1L0.88612315
70MAP2K30.88156237
71STK100.86231632
72CASK0.85364321
73PASK0.85331056
74ALK0.84786334
75OXSR10.84140994
76MAP4K20.84043990
77NEK90.83783360
78CHEK10.82896544
79AURKA0.82721943
80STK38L0.81321354
81TESK20.80134955
82TESK10.79038146
83BRAF0.75877435
84MAP3K120.75655626
85PAK30.74872795
86STK30.73309188
87CDK120.73170587
88CDK80.72520080
89MAP3K100.72333771
90CHEK20.71942157
91MAP3K40.69154023
92MAP3K130.67664079
93LRRK20.67170031
94TBK10.65780893
95PBK0.64689784
96CDK60.64464018
97NME20.63157802
98EPHA40.58102833
99FGFR10.58054407
100SRPK10.56728567
101DYRK30.56576071
102KDR0.56420968
103LIMK10.54980719
104MELK0.54598467
105BRD40.52472735
106CDK20.51010362
107DAPK10.48575148
108PNCK0.48530717
109FGFR20.47834766
110PRKCE0.47451926
111ATM0.47256243
112BCKDK0.46876144
113ERBB40.46106874
114AKT20.45944845
115OBSCN0.45551443
116PDGFRA0.45401719
117PRKCI0.43733223
118MOS0.43343841
119MAPK110.43271007
120MAP2K40.42696753
121STK240.41752377
122ERN10.41157448
123DYRK20.40830272
124NLK0.40818121
125STK40.39655358
126PAK10.39617445
127CSNK2A20.39396625
128FER0.38979951
129JAK30.38728750
130CSNK2A10.38657617
131LMTK20.37824904
132MINK10.37063342
133CSNK1E0.36883854
134NME10.35129535
135CDK90.32469700
136ZAP700.32367700
137PHKG20.31774638
138PHKG10.31774638
139PAK60.31368034
140ILK0.31148490
141PRKDC0.30980070
142GRK10.30813012
143PRKCG0.30540345
144CDK10.29212807
145MAP2K70.29041223
146FGR0.27887438
147YES10.27606995
148NEK60.26591116
149CLK10.25196354

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.94962212
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.79215812
3RNA transport_Homo sapiens_hsa030133.51989818
4Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.26568599
5Proteasome_Homo sapiens_hsa030503.11203525
6Mismatch repair_Homo sapiens_hsa034302.98901893
7Cell cycle_Homo sapiens_hsa041102.92553622
82-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.70164661
9Protein export_Homo sapiens_hsa030602.69298282
10Spliceosome_Homo sapiens_hsa030402.59020626
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.40647770
12Base excision repair_Homo sapiens_hsa034102.22759157
13One carbon pool by folate_Homo sapiens_hsa006702.09933296
14Nucleotide excision repair_Homo sapiens_hsa034202.07817876
15Steroid biosynthesis_Homo sapiens_hsa001002.06743180
16Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.05856902
17Biosynthesis of amino acids_Homo sapiens_hsa012302.05355527
18RNA polymerase_Homo sapiens_hsa030202.02491044
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.00532934
20Carbon metabolism_Homo sapiens_hsa012001.86626526
21Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.83404058
22Cysteine and methionine metabolism_Homo sapiens_hsa002701.82291066
23mRNA surveillance pathway_Homo sapiens_hsa030151.81997878
24Fatty acid elongation_Homo sapiens_hsa000621.79953769
25RNA degradation_Homo sapiens_hsa030181.77725800
26Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.73178491
27Oocyte meiosis_Homo sapiens_hsa041141.68292109
28Pyrimidine metabolism_Homo sapiens_hsa002401.63887508
29p53 signaling pathway_Homo sapiens_hsa041151.60631756
30Homologous recombination_Homo sapiens_hsa034401.53025232
31Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.50578384
32Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.44004334
33Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.40777876
34Thyroid cancer_Homo sapiens_hsa052161.39677998
35Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.24674146
36Basal transcription factors_Homo sapiens_hsa030221.18379850
37Legionellosis_Homo sapiens_hsa051341.17033125
38Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.16704081
39Parkinsons disease_Homo sapiens_hsa050121.15096679
40Oxidative phosphorylation_Homo sapiens_hsa001901.14629229
41Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.13314495
42Epstein-Barr virus infection_Homo sapiens_hsa051691.11106579
43Pentose phosphate pathway_Homo sapiens_hsa000301.08595821
44Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.08447834
45Central carbon metabolism in cancer_Homo sapiens_hsa052301.06231772
46Pyruvate metabolism_Homo sapiens_hsa006201.05345814
47Antigen processing and presentation_Homo sapiens_hsa046121.04070768
48Glutathione metabolism_Homo sapiens_hsa004801.03204788
49Ribosome_Homo sapiens_hsa030101.00804314
50Butanoate metabolism_Homo sapiens_hsa006500.97900562
51Herpes simplex infection_Homo sapiens_hsa051680.96512288
52Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.95706998
53Purine metabolism_Homo sapiens_hsa002300.94287073
54Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.93405600
55Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.92291732
56Cyanoamino acid metabolism_Homo sapiens_hsa004600.86338986
57Selenocompound metabolism_Homo sapiens_hsa004500.85667538
58HIF-1 signaling pathway_Homo sapiens_hsa040660.85423680
59Huntingtons disease_Homo sapiens_hsa050160.85283803
60Viral carcinogenesis_Homo sapiens_hsa052030.85135273
61Shigellosis_Homo sapiens_hsa051310.82423942
62Sulfur relay system_Homo sapiens_hsa041220.82261982
63Fatty acid metabolism_Homo sapiens_hsa012120.82104365
64mTOR signaling pathway_Homo sapiens_hsa041500.80706846
65HTLV-I infection_Homo sapiens_hsa051660.78371223
66Folate biosynthesis_Homo sapiens_hsa007900.76314830
67Viral myocarditis_Homo sapiens_hsa054160.75436631
68Non-homologous end-joining_Homo sapiens_hsa034500.74474731
69Arginine and proline metabolism_Homo sapiens_hsa003300.73857893
70Vitamin B6 metabolism_Homo sapiens_hsa007500.73345035
71Sulfur metabolism_Homo sapiens_hsa009200.69125120
72beta-Alanine metabolism_Homo sapiens_hsa004100.68165530
73* Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.66974854
74Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.61990783
75Galactose metabolism_Homo sapiens_hsa000520.61899334
76TGF-beta signaling pathway_Homo sapiens_hsa043500.60308773
77Pentose and glucuronate interconversions_Homo sapiens_hsa000400.59507680
78Small cell lung cancer_Homo sapiens_hsa052220.59290633
79Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.59022465
80Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.58878861
81Metabolic pathways_Homo sapiens_hsa011000.58417722
82Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.57829081
83Influenza A_Homo sapiens_hsa051640.57153322
84Bladder cancer_Homo sapiens_hsa052190.56494859
85Peroxisome_Homo sapiens_hsa041460.55964865
86Regulation of autophagy_Homo sapiens_hsa041400.55645886
87Collecting duct acid secretion_Homo sapiens_hsa049660.55467048
88Hepatitis B_Homo sapiens_hsa051610.53978921
89Adherens junction_Homo sapiens_hsa045200.53764651
90Alzheimers disease_Homo sapiens_hsa050100.53482603
91Hippo signaling pathway_Homo sapiens_hsa043900.52745831
92Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.52517958
93VEGF signaling pathway_Homo sapiens_hsa043700.52050870
94Arginine biosynthesis_Homo sapiens_hsa002200.51705510
95Circadian rhythm_Homo sapiens_hsa047100.51147848
96Fructose and mannose metabolism_Homo sapiens_hsa000510.49730757
97MicroRNAs in cancer_Homo sapiens_hsa052060.47469734
98Fanconi anemia pathway_Homo sapiens_hsa034600.46272540
99Colorectal cancer_Homo sapiens_hsa052100.45485039
100Vibrio cholerae infection_Homo sapiens_hsa051100.43805049
101Tryptophan metabolism_Homo sapiens_hsa003800.42773219
102Nicotine addiction_Homo sapiens_hsa050330.40499686
103Salmonella infection_Homo sapiens_hsa051320.40380779
104Chronic myeloid leukemia_Homo sapiens_hsa052200.39901958
105Wnt signaling pathway_Homo sapiens_hsa043100.39369886
106Propanoate metabolism_Homo sapiens_hsa006400.39270298
107Dilated cardiomyopathy_Homo sapiens_hsa054140.38205834
108Glucagon signaling pathway_Homo sapiens_hsa049220.37767502
109Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.37358339
110Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.37344959
111Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.37069941
112N-Glycan biosynthesis_Homo sapiens_hsa005100.36309532
113Pancreatic cancer_Homo sapiens_hsa052120.35472991
114Proteoglycans in cancer_Homo sapiens_hsa052050.35108487
115Insulin signaling pathway_Homo sapiens_hsa049100.34567049
116NOD-like receptor signaling pathway_Homo sapiens_hsa046210.34526049
117Thyroid hormone signaling pathway_Homo sapiens_hsa049190.34097258
118Tight junction_Homo sapiens_hsa045300.32417486
119Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.31393076
120Cardiac muscle contraction_Homo sapiens_hsa042600.31330067
121RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.30343327
122AMPK signaling pathway_Homo sapiens_hsa041520.30022411
123Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.29298633
124Drug metabolism - other enzymes_Homo sapiens_hsa009830.28935363
125Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.28788448
126Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.28468669
127Apoptosis_Homo sapiens_hsa042100.28115815
128Maturity onset diabetes of the young_Homo sapiens_hsa049500.27609663
129Non-small cell lung cancer_Homo sapiens_hsa052230.26794595
130Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.26710195
131Caffeine metabolism_Homo sapiens_hsa002320.25424077
132Fatty acid degradation_Homo sapiens_hsa000710.25148113
133Hedgehog signaling pathway_Homo sapiens_hsa043400.23611058
134Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.22407193
135FoxO signaling pathway_Homo sapiens_hsa040680.22148966
136Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.22043850
137Insulin resistance_Homo sapiens_hsa049310.21813298
138Leukocyte transendothelial migration_Homo sapiens_hsa046700.21699466
139Measles_Homo sapiens_hsa051620.21329536
140Starch and sucrose metabolism_Homo sapiens_hsa005000.21312386
141Primary bile acid biosynthesis_Homo sapiens_hsa001200.20433868
142Adipocytokine signaling pathway_Homo sapiens_hsa049200.19162672
143TNF signaling pathway_Homo sapiens_hsa046680.18635306
144Nitrogen metabolism_Homo sapiens_hsa009100.18178835
145Alcoholism_Homo sapiens_hsa050340.16916704
146Vitamin digestion and absorption_Homo sapiens_hsa049770.16887166
147Retinol metabolism_Homo sapiens_hsa008300.15323690

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