DNAJA3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the DNAJ/Hsp40 protein family. DNAJ/Hsp40 proteins stimulate the ATPase activity of Hsp70 chaperones and play critical roles in protein folding, degradation, and multimeric complex assembly. The encoded protein is localized to mitochondria and mediates several cellular processes including proliferation, survival and apoptotic signal transduction. The encoded protein also plays a critical role in tumor suppression through interactions with oncogenic proteins including ErbB2 and the p53 tumor suppressor protein. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1lysine metabolic process (GO:0006553)6.11084637
2lysine catabolic process (GO:0006554)6.11084637
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.78062240
4L-phenylalanine metabolic process (GO:0006558)5.78062240
5L-phenylalanine catabolic process (GO:0006559)5.72507850
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.72507850
7glyoxylate metabolic process (GO:0046487)5.37356322
8aromatic amino acid family catabolic process (GO:0009074)5.22517765
9cysteine metabolic process (GO:0006534)5.13282256
10kynurenine metabolic process (GO:0070189)5.09914595
112-oxoglutarate metabolic process (GO:0006103)4.94632911
12triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.86351331
13tryptophan catabolic process (GO:0006569)4.82056909
14indole-containing compound catabolic process (GO:0042436)4.82056909
15indolalkylamine catabolic process (GO:0046218)4.82056909
16aspartate family amino acid catabolic process (GO:0009068)4.80758163
17amino-acid betaine metabolic process (GO:0006577)4.78764257
18regulation of translational fidelity (GO:0006450)4.75574998
19alpha-linolenic acid metabolic process (GO:0036109)4.75388886
20proline biosynthetic process (GO:0006561)4.74299200
21fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.73022582
22serine family amino acid catabolic process (GO:0009071)4.71626819
23DNA strand elongation involved in DNA replication (GO:0006271)4.69378816
24sulfur amino acid catabolic process (GO:0000098)4.68815084
25folic acid-containing compound biosynthetic process (GO:0009396)4.66670064
26fatty acid beta-oxidation (GO:0006635)4.63812302
27tricarboxylic acid cycle (GO:0006099)4.63024040
28DNA strand elongation (GO:0022616)4.54495520
29tryptophan metabolic process (GO:0006568)4.50746924
30bile acid biosynthetic process (GO:0006699)4.50481015
31valine metabolic process (GO:0006573)4.43011930
32cellular ketone body metabolic process (GO:0046950)4.41237295
33glycine metabolic process (GO:0006544)4.40640420
34DNA unwinding involved in DNA replication (GO:0006268)4.39557489
35fatty acid oxidation (GO:0019395)4.32625942
36acetyl-CoA metabolic process (GO:0006084)4.31686275
37homocysteine metabolic process (GO:0050667)4.31651511
38regulation of triglyceride catabolic process (GO:0010896)4.31431415
39branched-chain amino acid catabolic process (GO:0009083)4.31120837
40urea metabolic process (GO:0019627)4.30516529
41urea cycle (GO:0000050)4.30516529
42alpha-amino acid catabolic process (GO:1901606)4.29422110
43complement activation, alternative pathway (GO:0006957)4.27890018
44lipid oxidation (GO:0034440)4.23409434
45serine family amino acid metabolic process (GO:0009069)4.21190854
46carnitine metabolic process (GO:0009437)4.20405370
47fatty acid transmembrane transport (GO:1902001)4.16759048
48fatty acid catabolic process (GO:0009062)4.16674504
49regulation of protein activation cascade (GO:2000257)4.13806960
50negative regulation of fibrinolysis (GO:0051918)4.12602472
51carnitine shuttle (GO:0006853)4.11076117
52short-chain fatty acid metabolic process (GO:0046459)4.10946285
53cellular amino acid catabolic process (GO:0009063)4.08403674
54branched-chain amino acid metabolic process (GO:0009081)4.05587523
55DNA replication initiation (GO:0006270)4.04760673
56nitrogen cycle metabolic process (GO:0071941)3.99628288
57serine family amino acid biosynthetic process (GO:0009070)3.97193300
58oxaloacetate metabolic process (GO:0006107)3.96979176
59tricarboxylic acid metabolic process (GO:0072350)3.95227138
60monocarboxylic acid catabolic process (GO:0072329)3.94943301
61cellular modified amino acid catabolic process (GO:0042219)3.93223048
62high-density lipoprotein particle remodeling (GO:0034375)3.91200924
63regulation of complement activation (GO:0030449)3.88988049
64triglyceride homeostasis (GO:0070328)3.88104065
65acylglycerol homeostasis (GO:0055090)3.88104065
66aromatic amino acid family metabolic process (GO:0009072)3.86571935
67tetrahydrofolate metabolic process (GO:0046653)3.85252662
68telomere maintenance via semi-conservative replication (GO:0032201)3.85037333
69ethanol oxidation (GO:0006069)3.84725420
70L-serine metabolic process (GO:0006563)3.84543621
71organic acid catabolic process (GO:0016054)3.84070888
72carboxylic acid catabolic process (GO:0046395)3.84070888
73negative regulation of fatty acid biosynthetic process (GO:0045717)3.83618618
74positive regulation of fatty acid beta-oxidation (GO:0032000)3.81945338
75NADH metabolic process (GO:0006734)3.81287215
76ketone body metabolic process (GO:1902224)3.80103214
77regulation of sequestering of triglyceride (GO:0010889)3.80077257
78protein carboxylation (GO:0018214)3.80073444
79peptidyl-glutamic acid carboxylation (GO:0017187)3.80073444
80succinate metabolic process (GO:0006105)3.79040304
81coenzyme catabolic process (GO:0009109)3.77227577
82bile acid metabolic process (GO:0008206)3.76340440
83glutamate metabolic process (GO:0006536)3.76117479
84regulation of fibrinolysis (GO:0051917)3.75280606
85dicarboxylic acid biosynthetic process (GO:0043650)3.72454572
86DNA replication checkpoint (GO:0000076)3.66648323
87biotin metabolic process (GO:0006768)3.61912581
88regulation of fatty acid oxidation (GO:0046320)3.61364537
89folic acid metabolic process (GO:0046655)3.60657386
90cellular glucuronidation (GO:0052695)3.57702129
91positive regulation of fatty acid oxidation (GO:0046321)3.56391619
92proline metabolic process (GO:0006560)3.54330719
93peptidyl-arginine omega-N-methylation (GO:0035247)3.54212799
94regulation of fatty acid beta-oxidation (GO:0031998)3.48389892
95plasma lipoprotein particle clearance (GO:0034381)3.47091745
96dicarboxylic acid metabolic process (GO:0043648)3.46335605
97plasma lipoprotein particle remodeling (GO:0034369)3.45627254
98protein-lipid complex remodeling (GO:0034368)3.45627254
99macromolecular complex remodeling (GO:0034367)3.45627254
100reverse cholesterol transport (GO:0043691)3.45139491
101Golgi transport vesicle coating (GO:0048200)3.43781227
102COPI coating of Golgi vesicle (GO:0048205)3.43781227
103nuclear pore complex assembly (GO:0051292)3.43102906
104benzene-containing compound metabolic process (GO:0042537)3.42542977
105regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.39589329
106folic acid-containing compound metabolic process (GO:0006760)3.39503985
107phospholipid homeostasis (GO:0055091)3.39434444
108negative regulation of fatty acid metabolic process (GO:0045922)3.39336169
109regulation of cholesterol esterification (GO:0010872)3.39178413
110pteridine-containing compound biosynthetic process (GO:0042559)3.37950394
111spliceosomal tri-snRNP complex assembly (GO:0000244)3.37414075
112fatty acid homeostasis (GO:0055089)3.34163504
113positive regulation of lipid catabolic process (GO:0050996)3.33602120
114tyrosine metabolic process (GO:0006570)3.33031370
115regulation of cholesterol metabolic process (GO:0090181)3.31680795
116negative regulation of sterol transport (GO:0032372)3.31437896
117negative regulation of cholesterol transport (GO:0032375)3.31437896
118mitotic sister chromatid segregation (GO:0000070)3.31289758
119mitotic chromosome condensation (GO:0007076)3.28069549
120tRNA methylation (GO:0030488)3.28066783
121indolalkylamine metabolic process (GO:0006586)3.27704158
122tRNA aminoacylation for protein translation (GO:0006418)3.27693397
123IMP biosynthetic process (GO:0006188)3.27412701
124DNA synthesis involved in DNA repair (GO:0000731)3.26580522
125NAD metabolic process (GO:0019674)3.25949407
126formation of translation preinitiation complex (GO:0001731)3.25804574
127amino-acid betaine transport (GO:0015838)3.23663114
128negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)3.23149348
129telomere maintenance via recombination (GO:0000722)3.23087244
130tRNA aminoacylation (GO:0043039)3.19139631
131amino acid activation (GO:0043038)3.19139631
132ribosomal small subunit biogenesis (GO:0042274)3.18927557
133pseudouridine synthesis (GO:0001522)3.18043193
134maturation of 5.8S rRNA (GO:0000460)3.16241896
135IMP metabolic process (GO:0046040)3.15935606
136rRNA transcription (GO:0009303)3.13816114
137negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.13110987
138negative regulation of cell cycle G2/M phase transition (GO:1902750)3.12769718
139ribosome assembly (GO:0042255)3.12404998
140nucleobase biosynthetic process (GO:0046112)3.09543832
141somatic diversification of immune receptors via somatic mutation (GO:0002566)3.05880045
142somatic hypermutation of immunoglobulin genes (GO:0016446)3.05880045
143nuclear pore organization (GO:0006999)3.03357224
144nucleobase-containing small molecule interconversion (GO:0015949)3.00023565
145regulation of mitochondrial translation (GO:0070129)2.98395275
146regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.93863657
147peptidyl-histidine modification (GO:0018202)2.93762605
148sister chromatid segregation (GO:0000819)2.92296594
149positive regulation of chromosome segregation (GO:0051984)2.90265831
150ribonucleoprotein complex biogenesis (GO:0022613)2.88975932
151pteridine-containing compound metabolic process (GO:0042558)2.88863088
152regulation of translational termination (GO:0006449)2.88649964
153histone arginine methylation (GO:0034969)2.88114771
154mitotic nuclear envelope disassembly (GO:0007077)2.87525367
155rRNA modification (GO:0000154)2.86503592
156ribosome biogenesis (GO:0042254)2.85713144
157mitochondrial fusion (GO:0008053)2.82285669
158regulation of translational elongation (GO:0006448)2.82234024
159mitotic recombination (GO:0006312)2.81785769
160negative regulation of mRNA processing (GO:0050686)2.81592629
161viral mRNA export from host cell nucleus (GO:0046784)2.81111143
162mitochondrial RNA metabolic process (GO:0000959)2.80021816
163retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.77411670
164ribosomal large subunit biogenesis (GO:0042273)2.74914634
165DNA duplex unwinding (GO:0032508)2.72454094
166nucleotide-excision repair, DNA gap filling (GO:0006297)2.70065652
167peptidyl-arginine N-methylation (GO:0035246)2.67601048
168peptidyl-arginine methylation (GO:0018216)2.67601048
169protein complex localization (GO:0031503)2.66298295
170alpha-amino acid biosynthetic process (GO:1901607)2.66262243
171sulfur amino acid biosynthetic process (GO:0000097)2.66195642
172tRNA modification (GO:0006400)2.65570020
173aspartate family amino acid biosynthetic process (GO:0009067)2.65252918
174maturation of SSU-rRNA (GO:0030490)2.63219303
175membrane disassembly (GO:0030397)2.61135347
176nuclear envelope disassembly (GO:0051081)2.61135347
177telomere maintenance via telomere lengthening (GO:0010833)2.60832170
178DNA geometric change (GO:0032392)2.60326062
179protein localization to chromosome, centromeric region (GO:0071459)2.59433621
180mitotic metaphase plate congression (GO:0007080)2.59326918
181gluconeogenesis (GO:0006094)2.59218736
182protein K6-linked ubiquitination (GO:0085020)2.58923496
183rRNA processing (GO:0006364)2.55710787
184GDP-mannose metabolic process (GO:0019673)2.55126717
185pore complex assembly (GO:0046931)2.54979967
186monosaccharide biosynthetic process (GO:0046364)2.54289816
187mitotic G1 DNA damage checkpoint (GO:0031571)2.53506175
188glutamine metabolic process (GO:0006541)2.50774575
189hexose biosynthetic process (GO:0019319)2.49148271
190peptidyl-lysine dimethylation (GO:0018027)2.49096572
191nuclear envelope reassembly (GO:0031468)2.48813802
192mitotic nuclear envelope reassembly (GO:0007084)2.48813802
193chromosome condensation (GO:0030261)2.47795636
194purine nucleobase biosynthetic process (GO:0009113)2.47000848

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.58173753
2E2F7_22180533_ChIP-Seq_HELA_Human7.05876142
3* PPARG_19300518_ChIP-PET_3T3-L1_Mouse7.02564316
4* RXR_22158963_ChIP-Seq_LIVER_Mouse6.44483563
5PPARA_22158963_ChIP-Seq_LIVER_Mouse5.83402575
6LXR_22158963_ChIP-Seq_LIVER_Mouse4.83392882
7EGR1_23403033_ChIP-Seq_LIVER_Mouse4.59013591
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.00299913
9FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.83158210
10TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.78498225
11CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.19135967
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.18000077
13* NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.00493725
14FOXM1_23109430_ChIP-Seq_U2OS_Human2.73229201
15XRN2_22483619_ChIP-Seq_HELA_Human2.48934790
16FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.45581887
17ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.43948018
18EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.27888007
19THAP11_20581084_ChIP-Seq_MESCs_Mouse2.23574377
20HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.19149805
21CLOCK_20551151_ChIP-Seq_293T_Human2.18316029
22E2F4_17652178_ChIP-ChIP_JURKAT_Human2.18112043
23MYC_22102868_ChIP-Seq_BL_Human2.12872759
24ZNF263_19887448_ChIP-Seq_K562_Human2.02607245
25GATA1_22025678_ChIP-Seq_K562_Human1.94857657
26* MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.93861565
27DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.86128730
28E2F1_21310950_ChIP-Seq_MCF-7_Human1.80124363
29CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.79195611
30TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.77244079
31TTF2_22483619_ChIP-Seq_HELA_Human1.73682740
32* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.66886929
33* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.65503515
34* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.55361640
35* EST1_17652178_ChIP-ChIP_JURKAT_Human1.53290938
36NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.53226455
37* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.49829576
38CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.49554907
39YY1_21170310_ChIP-Seq_MESCs_Mouse1.49510689
40CIITA_25753668_ChIP-Seq_RAJI_Human1.42513440
41RARG_19884340_ChIP-ChIP_MEFs_Mouse1.42150600
42* MYC_18555785_ChIP-Seq_MESCs_Mouse1.35009040
43CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.33482795
44STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.32784591
45PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.31325171
46MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.30792120
47AR_21909140_ChIP-Seq_LNCAP_Human1.29186516
48* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.27744582
49VDR_21846776_ChIP-Seq_THP-1_Human1.25049644
50* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.23575224
51TP63_17297297_ChIP-ChIP_HaCaT_Human1.22358407
52POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.21132796
53SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.21058577
54HNF4A_19822575_ChIP-Seq_HepG2_Human1.17351524
55E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.17035715
56* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.16303987
57CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.14686857
58* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.13982337
59PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.13818660
60FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.13809774
61MYC_18358816_ChIP-ChIP_MESCs_Mouse1.13808240
62FOXP1_21924763_ChIP-Seq_HESCs_Human1.13270502
63* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.12845513
64TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.12164090
65SRF_21415370_ChIP-Seq_HL-1_Mouse1.11774829
66* VDR_23849224_ChIP-Seq_CD4+_Human1.11572501
67CREB1_15753290_ChIP-ChIP_HEK293T_Human1.11529449
68* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.09950782
69SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.09163189
70FOXA2_19822575_ChIP-Seq_HepG2_Human1.08595035
71* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.07361939
72STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.06619044
73BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.06353807
74PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.04115956
75ESR1_15608294_ChIP-ChIP_MCF-7_Human1.03062580
76* RXRA_24833708_ChIP-Seq_LIVER_Mouse1.02808092
77HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.02647577
78ZFX_18555785_ChIP-Seq_MESCs_Mouse1.02293386
79* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.02157733
80* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01175931
81MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.00877436
82ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.99970069
83* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98860157
84DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.97074919
85SRY_22984422_ChIP-ChIP_TESTIS_Rat0.96107673
86CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.95916183
87CHD1_26751641_Chip-Seq_LNCaP_Human0.95529615
88PADI4_21655091_ChIP-ChIP_MCF-7_Human0.94681615
89ELF1_20517297_ChIP-Seq_JURKAT_Human0.94545822
90CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.93558452
91PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.93486356
92SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.91321673
93SMC4_20622854_ChIP-Seq_HELA_Human0.90669877
94E2F1_20622854_ChIP-Seq_HELA_Human0.89617081
95PHF8_20622854_ChIP-Seq_HELA_Human0.89149432
96KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.88311004
97* ATF3_27146783_Chip-Seq_COLON_Human0.87726634
98* NELFA_20434984_ChIP-Seq_ESCs_Mouse0.87324181
99SOX2_27498859_Chip-Seq_STOMACH_Mouse0.86669818
100* MYC_19030024_ChIP-ChIP_MESCs_Mouse0.86176013
101GATA4_21415370_ChIP-Seq_HL-1_Mouse0.85415714
102TBX20_22328084_ChIP-Seq_HEART_Mouse0.84715465
103TBX20_22080862_ChIP-Seq_HEART_Mouse0.84715465
104* RARA_24833708_ChIP-Seq_LIVER_Mouse0.82927479
105SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.82645947
106NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.82110954
107THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.80562186
108* ETS1_20019798_ChIP-Seq_JURKAT_Human0.80543402
109FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.80497279
110* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.79159967
111* DCP1A_22483619_ChIP-Seq_HELA_Human0.77125269
112ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.75751883
113GABP_19822575_ChIP-Seq_HepG2_Human0.74885875
114TBX5_21415370_ChIP-Seq_HL-1_Mouse0.72718928
115* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.72566916
116PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.70242684
117KLF4_18555785_ChIP-Seq_MESCs_Mouse0.69725467
118GATA4_25053715_ChIP-Seq_YYC3_Human0.68758596
119NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.68632444
120HTT_18923047_ChIP-ChIP_STHdh_Human0.68266085
121GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.67638192
122SOX2_18692474_ChIP-Seq_MEFs_Mouse0.67340071
123OCT4_18692474_ChIP-Seq_MEFs_Mouse0.65827517
124TET1_21451524_ChIP-Seq_MESCs_Mouse0.65217183
125HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.65025098
126P68_20966046_ChIP-Seq_HELA_Human0.64770577
127* AUTS2_25519132_ChIP-Seq_293T-REX_Human0.64528309
128NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.64448440
129* MYCN_18555785_ChIP-Seq_MESCs_Mouse0.63729652
130BCOR_27268052_Chip-Seq_Bcells_Human0.63224088
131CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.63135703
132SALL4_18804426_ChIP-ChIP_XEN_Mouse0.62323908
133TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.62275722
134NANOG_18555785_ChIP-Seq_MESCs_Mouse0.62176585
135GATA6_25053715_ChIP-Seq_YYC3_Human0.60994194
136BCL6_27268052_Chip-Seq_Bcells_Human0.60464291
137NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.59452703
138KDM5A_27292631_Chip-Seq_BREAST_Human0.58830247
139RACK7_27058665_Chip-Seq_MCF-7_Human0.58384141
140* LXR_22292898_ChIP-Seq_THP-1_Human0.57470846
141GABP_17652178_ChIP-ChIP_JURKAT_Human0.56783408
142ESR2_21235772_ChIP-Seq_MCF-7_Human0.56721300
143MYC_19079543_ChIP-ChIP_MESCs_Mouse0.56275698
144RBPJ_22232070_ChIP-Seq_NCS_Mouse0.56034474
145FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.55969928
146* RARB_24833708_ChIP-Seq_LIVER_Mouse0.55962446
147HIF1A_21447827_ChIP-Seq_MCF-7_Human0.55282820
148POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.55103014
149KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.54742940
150FOXP3_21729870_ChIP-Seq_TREG_Human0.53483554

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.47741849
2MP0005360_urolithiasis5.96116920
3MP0005085_abnormal_gallbladder_physiolo5.25089463
4MP0005365_abnormal_bile_salt4.93803251
5MP0003806_abnormal_nucleotide_metabolis4.53959006
6MP0010094_abnormal_chromosome_stability4.26026753
7MP0003693_abnormal_embryo_hatching3.83011995
8MP0008875_abnormal_xenobiotic_pharmacok3.74412600
9MP0003111_abnormal_nucleus_morphology3.60279055
10MP0003252_abnormal_bile_duct3.28148282
11MP0002837_dystrophic_cardiac_calcinosis3.25987367
12MP0003646_muscle_fatigue3.01271965
13MP0010329_abnormal_lipoprotein_level2.95734086
14MP0009840_abnormal_foam_cell2.87215676
15MP0004957_abnormal_blastocyst_morpholog2.87093208
16MP0005332_abnormal_amino_acid2.84134498
17MP0008058_abnormal_DNA_repair2.82094904
18MP0003077_abnormal_cell_cycle2.81724994
19MP0003195_calcinosis2.63641838
20MP0008057_abnormal_DNA_replication2.63612589
21MP0005083_abnormal_biliary_tract2.39672469
22MP0005670_abnormal_white_adipose2.23166668
23MP0008932_abnormal_embryonic_tissue2.21604529
24* MP0006036_abnormal_mitochondrial_physio2.16778818
25MP0003191_abnormal_cellular_cholesterol2.16620575
26MP0004130_abnormal_muscle_cell2.05780321
27MP0001666_abnormal_nutrient_absorption2.00606675
28MP0000609_abnormal_liver_physiology1.95146124
29MP0002877_abnormal_melanocyte_morpholog1.94468358
30MP0005319_abnormal_enzyme/_coenzyme1.94299164
31MP0002118_abnormal_lipid_homeostasis1.93665165
32MP0004084_abnormal_cardiac_muscle1.89608532
33MP0002234_abnormal_pharynx_morphology1.89138878
34MP0001730_embryonic_growth_arrest1.87487622
35MP0005076_abnormal_cell_differentiation1.74038936
36MP0003186_abnormal_redox_activity1.65095744
37MP0005666_abnormal_adipose_tissue1.62386410
38MP0008007_abnormal_cellular_replicative1.61969727
39* MP0005330_cardiomyopathy1.61512946
40MP0005584_abnormal_enzyme/coenzyme_acti1.59486387
41MP0004215_abnormal_myocardial_fiber1.59259402
42MP0004036_abnormal_muscle_relaxation1.57084370
43MP0003705_abnormal_hypodermis_morpholog1.56940908
44MP0010234_abnormal_vibrissa_follicle1.56475968
45MP0004019_abnormal_vitamin_homeostasis1.56378290
46MP0001764_abnormal_homeostasis1.55088666
47MP0009643_abnormal_urine_homeostasis1.50473293
48MP0000751_myopathy1.49400333
49MP0000350_abnormal_cell_proliferation1.48653125
50* MP0001672_abnormal_embryogenesis/_devel1.45488875
51* MP0005380_embryogenesis_phenotype1.45488875
52MP0004145_abnormal_muscle_electrophysio1.45058371
53MP0002269_muscular_atrophy1.43517922
54MP0002138_abnormal_hepatobiliary_system1.40329569
55MP0003786_premature_aging1.39915393
56MP0001348_abnormal_lacrimal_gland1.39682464
57MP0000749_muscle_degeneration1.39318523
58* MP0003984_embryonic_growth_retardation1.36451608
59* MP0002080_prenatal_lethality1.33258268
60MP0001697_abnormal_embryo_size1.32654017
61MP0003868_abnormal_feces_composition1.31272902
62* MP0002088_abnormal_embryonic_growth/wei1.30830742
63MP0003283_abnormal_digestive_organ1.27795500
64MP0005266_abnormal_metabolism1.21442978
65MP0005501_abnormal_skin_physiology1.21408825
66MP0004043_abnormal_pH_regulation1.21168745
67* MP0006035_abnormal_mitochondrial_morpho1.15433479
68MP0002971_abnormal_brown_adipose1.14927785
69* MP0004087_abnormal_muscle_fiber1.14299186
70MP0002078_abnormal_glucose_homeostasis1.13636806
71MP0000598_abnormal_liver_morphology1.11924585
72MP0003656_abnormal_erythrocyte_physiolo1.11593697
73MP0001346_abnormal_lacrimal_gland1.11186440
74MP0000678_abnormal_parathyroid_gland1.10701905
75MP0008775_abnormal_heart_ventricle1.10265838
76MP0002098_abnormal_vibrissa_morphology1.09389379
77MP0000313_abnormal_cell_death1.07907721
78MP0010307_abnormal_tumor_latency1.07778767
79MP0002249_abnormal_larynx_morphology1.06749096
80MP0001873_stomach_inflammation1.06480974
81* MP0001544_abnormal_cardiovascular_syste1.05053748
82* MP0005385_cardiovascular_system_phenoty1.05053748
83MP0002160_abnormal_reproductive_system1.03257619
84MP0009697_abnormal_copulation1.03099855
85MP0000747_muscle_weakness1.02990519
86MP0005451_abnormal_body_composition1.02237875
87MP0004185_abnormal_adipocyte_glucose1.01288141
88MP0004197_abnormal_fetal_growth/weight/0.99816704
89MP0010030_abnormal_orbit_morphology0.98190207
90* MP0000358_abnormal_cell_content/0.96808241
91* MP0003221_abnormal_cardiomyocyte_apopto0.96736618
92MP0005636_abnormal_mineral_homeostasis0.96140823
93MP0000467_abnormal_esophagus_morphology0.96069477
94MP0004233_abnormal_muscle_weight0.95912397
95* MP0002972_abnormal_cardiac_muscle0.95473777
96MP0002019_abnormal_tumor_incidence0.94369352
97MP0000750_abnormal_muscle_regeneration0.92382927
98* MP0010630_abnormal_cardiac_muscle0.92308631
99MP0005376_homeostasis/metabolism_phenot0.92267919
100MP0005535_abnormal_body_temperature0.90885835
101MP0002085_abnormal_embryonic_tissue0.90768745
102MP0005375_adipose_tissue_phenotype0.90599620
103MP0002084_abnormal_developmental_patter0.90562398
104* MP0005620_abnormal_muscle_contractility0.90133420
105MP0004858_abnormal_nervous_system0.89641180
106MP0002086_abnormal_extraembryonic_tissu0.88234266
107MP0005408_hypopigmentation0.87718411
108MP0005334_abnormal_fat_pad0.85747849
109MP0002210_abnormal_sex_determination0.85198722
110MP0009642_abnormal_blood_homeostasis0.81351885
111MP0002396_abnormal_hematopoietic_system0.80600011
112MP0009763_increased_sensitivity_to0.80184625
113MP0001756_abnormal_urination0.80109167
114* MP0006138_congestive_heart_failure0.78763465
115MP0005647_abnormal_sex_gland0.78757934
116MP0010368_abnormal_lymphatic_system0.78559895
117MP0002332_abnormal_exercise_endurance0.77423706
118MP0000733_abnormal_muscle_development0.77242468
119MP0009780_abnormal_chondrocyte_physiolo0.75357193
120MP0002106_abnormal_muscle_physiology0.75323778
121MP0000579_abnormal_nail_morphology0.75051412
122MP0003137_abnormal_impulse_conducting0.74688693
123MP0001727_abnormal_embryo_implantation0.72832723
124MP0000537_abnormal_urethra_morphology0.71894958
125MP0001929_abnormal_gametogenesis0.71354885
126MP0004147_increased_porphyrin_level0.70254931
127MP0010352_gastrointestinal_tract_polyps0.68516017
128MP0002938_white_spotting0.67838487
129MP0002796_impaired_skin_barrier0.67765821
130MP0000230_abnormal_systemic_arterial0.67324056
131MP0001145_abnormal_male_reproductive0.66076672
132MP0002970_abnormal_white_adipose0.65949476
133MP0004782_abnormal_surfactant_physiolog0.65501867
134MP0008469_abnormal_protein_level0.65325922
135MP0001661_extended_life_span0.63148050
136MP0005220_abnormal_exocrine_pancreas0.62455678
137MP0009672_abnormal_birth_weight0.62378803
138MP0000604_amyloidosis0.61967635
139MP0000759_abnormal_skeletal_muscle0.60993065
140MP0003011_delayed_dark_adaptation0.59470702
141MP0005448_abnormal_energy_balance0.58385112
142MP0009115_abnormal_fat_cell0.55353663
143MP0005369_muscle_phenotype0.54296407
144MP0000013_abnormal_adipose_tissue0.54211348
145MP0004085_abnormal_heartbeat0.53664942
146MP0009764_decreased_sensitivity_to0.53282606
147MP0003953_abnormal_hormone_level0.52425710
148MP0003566_abnormal_cell_adhesion0.51546634
149MP0003567_abnormal_fetal_cardiomyocyte0.51135050
150MP0004484_altered_response_of0.51017631
151MP0003718_maternal_effect0.50668609
152MP0002136_abnormal_kidney_physiology0.48958277
153MP0005165_increased_susceptibility_to0.45478266
154MP0003329_amyloid_beta_deposits0.45193972
155MP0008961_abnormal_basal_metabolism0.44503394
156MP0005084_abnormal_gallbladder_morpholo0.44085619
157MP0000003_abnormal_adipose_tissue0.43012459

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)5.14976066
2Intrahepatic cholestasis (HP:0001406)5.10813116
3Hypoglycemic coma (HP:0001325)5.10675942
4Hyperglycinuria (HP:0003108)4.93570380
5Hyperammonemia (HP:0001987)4.81077062
6Ketosis (HP:0001946)4.77534154
7Xanthomatosis (HP:0000991)4.70619698
8Deep venous thrombosis (HP:0002625)4.67561111
9Abnormality of monocarboxylic acid metabolism (HP:0010996)4.65286406
10Abnormality of glycine metabolism (HP:0010895)4.49294878
11Abnormality of serine family amino acid metabolism (HP:0010894)4.49294878
12Abnormality of fatty-acid metabolism (HP:0004359)4.41581965
13Hypobetalipoproteinemia (HP:0003563)4.38847858
14Ketoacidosis (HP:0001993)4.37315996
15Hyperglycinemia (HP:0002154)4.26266027
16Myoglobinuria (HP:0002913)4.02382329
17Prolonged partial thromboplastin time (HP:0003645)3.98200660
18Dicarboxylic aciduria (HP:0003215)3.93735645
19Abnormality of dicarboxylic acid metabolism (HP:0010995)3.93735645
20Hyperlipoproteinemia (HP:0010980)3.90956916
21Progressive muscle weakness (HP:0003323)3.84946326
22Testicular atrophy (HP:0000029)3.83322442
23Hypolipoproteinemia (HP:0010981)3.77374595
24Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.74753535
25Hypoalphalipoproteinemia (HP:0003233)3.62370182
26Complement deficiency (HP:0004431)3.53115715
27Abnormality of glutamine family amino acid metabolism (HP:0010902)3.49136154
28Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.41120458
29Chromosomal breakage induced by crosslinking agents (HP:0003221)3.36502851
30Rhabdomyolysis (HP:0003201)3.34073644
31Generalized aminoaciduria (HP:0002909)3.31716834
32Cerebral edema (HP:0002181)3.30173796
33Abnormality of aspartate family amino acid metabolism (HP:0010899)3.26772940
34Abnormality of serum amino acid levels (HP:0003112)3.26673850
35Epidermoid cyst (HP:0200040)3.26353511
36Microvesicular hepatic steatosis (HP:0001414)3.25031481
37Abnormality of sulfur amino acid metabolism (HP:0004339)3.19201214
38Hepatic necrosis (HP:0002605)3.18927356
39Lethargy (HP:0001254)3.17298182
40Gout (HP:0001997)3.15392735
41Chromsome breakage (HP:0040012)3.13727716
42Abnormality of the intrinsic pathway (HP:0010989)3.08709347
43Metabolic acidosis (HP:0001942)3.04182928
44Abnormality of methionine metabolism (HP:0010901)3.00522864
45Myopathic facies (HP:0002058)3.00113657
46Muscle fiber inclusion bodies (HP:0100299)2.93029678
47Abnormality of the common coagulation pathway (HP:0010990)2.92858787
48Birth length less than 3rd percentile (HP:0003561)2.92780430
49Hyperacusis (HP:0010780)2.87555281
50Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.83516461
51Hyperinsulinemic hypoglycemia (HP:0000825)2.81135834
52Joint hemorrhage (HP:0005261)2.77627236
53Abnormality of purine metabolism (HP:0004352)2.75350680
54Abnormality of nucleobase metabolism (HP:0010932)2.73307283
55Nemaline bodies (HP:0003798)2.73283287
56Fat malabsorption (HP:0002630)2.73163149
57Exercise-induced muscle cramps (HP:0003710)2.73100144
58Hyperbilirubinemia (HP:0002904)2.72250621
59Abnormality of pyrimidine metabolism (HP:0004353)2.69220488
60Delayed CNS myelination (HP:0002188)2.69097176
61Proximal tubulopathy (HP:0000114)2.67866589
62Exercise-induced myalgia (HP:0003738)2.64230256
63Nausea (HP:0002018)2.64052499
64Squamous cell carcinoma (HP:0002860)2.62142695
65Hypoglycemic seizures (HP:0002173)2.61762721
66Late onset (HP:0003584)2.61303378
67Unilateral renal agenesis (HP:0000122)2.60403158
68Palpitations (HP:0001962)2.58471501
69Progressive external ophthalmoplegia (HP:0000590)2.57815008
70Abnormality of complement system (HP:0005339)2.52770142
71Vomiting (HP:0002013)2.50291569
72Poikiloderma (HP:0001029)2.45505875
73Acute encephalopathy (HP:0006846)2.45217735
74Ragged-red muscle fibers (HP:0003200)2.42870467
75Hypercholesterolemia (HP:0003124)2.40740949
76Sudden death (HP:0001699)2.39792082
77Cholelithiasis (HP:0001081)2.39475036
78Increased muscle lipid content (HP:0009058)2.39452216
79Skin nodule (HP:0200036)2.35514588
80Increased purine levels (HP:0004368)2.35299266
81Hyperuricemia (HP:0002149)2.35299266
82Abnormal gallbladder morphology (HP:0012437)2.34321579
83Neonatal onset (HP:0003623)2.33168858
84Reticulocytopenia (HP:0001896)2.33159757
85Breast hypoplasia (HP:0003187)2.30682999
86Hepatocellular necrosis (HP:0001404)2.30364483
87Achilles tendon contracture (HP:0001771)2.29917218
88Lactic acidosis (HP:0003128)2.28572327
89Hepatocellular carcinoma (HP:0001402)2.27731614
90Spastic diplegia (HP:0001264)2.25997303
91Renal cortical cysts (HP:0000803)2.25077864
92Hyperglycemia (HP:0003074)2.23290153
93Calcaneovalgus deformity (HP:0001848)2.20999173
94Dysmetric saccades (HP:0000641)2.20839185
95Ventricular tachycardia (HP:0004756)2.20283106
96Entropion (HP:0000621)2.20185530
97Abnormality of cells of the erythroid lineage (HP:0012130)2.18454043
98Abnormality of the Achilles tendon (HP:0005109)2.17909823
99Abnormality of reticulocytes (HP:0004312)2.15635212
100Abnormal number of erythroid precursors (HP:0012131)2.15513232
101Abnormality of glycolysis (HP:0004366)2.15374301
102Increased serum pyruvate (HP:0003542)2.15374301
103Abnormality of alanine metabolism (HP:0010916)2.14950127
104Hyperalaninemia (HP:0003348)2.14950127
105Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.14950127
106Abnormality of proline metabolism (HP:0010907)2.13698700
107Hydroxyprolinuria (HP:0003080)2.13698700
108Increased serum lactate (HP:0002151)2.12659961
109Insomnia (HP:0100785)2.11372611
110Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.10547952
111Decreased activity of mitochondrial respiratory chain (HP:0008972)2.10547952
112Right ventricular cardiomyopathy (HP:0011663)2.10296758
113Reticulocytosis (HP:0001923)2.07334112
114Septate vagina (HP:0001153)2.07024118
115Conjugated hyperbilirubinemia (HP:0002908)2.06178394
116Abnormal cartilage morphology (HP:0002763)2.05291970
117Hypoplasia of the capital femoral epiphysis (HP:0003090)2.05247722
118Abnormal mitochondria in muscle tissue (HP:0008316)2.01782341
119Cutaneous melanoma (HP:0012056)2.00873273
120Asymmetric septal hypertrophy (HP:0001670)1.98545732
121Abnormality of urine glucose concentration (HP:0011016)1.97757715
122Glycosuria (HP:0003076)1.97757715
123Type I transferrin isoform profile (HP:0003642)1.97575823
124Irritability (HP:0000737)1.97518016
125Methylmalonic aciduria (HP:0012120)1.96095095
126Microretrognathia (HP:0000308)1.95616065
127Steatorrhea (HP:0002570)1.94679242
128Pancreatitis (HP:0001733)1.94178795
129Muscle stiffness (HP:0003552)1.93587427
130Ependymoma (HP:0002888)1.93566674
131Sensorimotor neuropathy (HP:0007141)1.93190677
132Abnormal gallbladder physiology (HP:0012438)1.92242398
133Cholecystitis (HP:0001082)1.92242398
134Atrioventricular block (HP:0001678)1.92144477
135Centrally nucleated skeletal muscle fibers (HP:0003687)1.91948894
136Lipoatrophy (HP:0100578)1.91936266
137Patellar aplasia (HP:0006443)1.90916971
138Myocardial infarction (HP:0001658)1.90281382
139Sparse lateral eyebrow (HP:0005338)1.89507218
140Dilated cardiomyopathy (HP:0001644)1.89397608
141Abnormality of the calcaneus (HP:0008364)1.88190312
142Opisthotonus (HP:0002179)1.88127449
143Trismus (HP:0000211)1.86654284
144Multiple enchondromatosis (HP:0005701)1.86035199
145Exercise intolerance (HP:0003546)1.85760897
146Deformed tarsal bones (HP:0008119)1.84903550
147Increased intramyocellular lipid droplets (HP:0012240)1.81643888
148Aplasia/Hypoplasia of the patella (HP:0006498)1.81394403
149Abnormality of the preputium (HP:0100587)1.78445725
150Reduced antithrombin III activity (HP:0001976)1.76317255
151Abnormality of subcutaneous fat tissue (HP:0001001)1.70921358
152High pitched voice (HP:0001620)1.69297260
153Spastic paraparesis (HP:0002313)1.68438184
154Adducted thumb (HP:0001181)1.66528030
155Increased connective tissue (HP:0009025)1.65372397
156EMG: myopathic abnormalities (HP:0003458)1.64873000
157Abnormal protein glycosylation (HP:0012346)1.61734669
158Abnormal glycosylation (HP:0012345)1.61734669
159Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.61734669
160Abnormal protein N-linked glycosylation (HP:0012347)1.61734669
161Selective tooth agenesis (HP:0001592)1.61581561
162Abnormality of the gallbladder (HP:0005264)1.61522116
163Abnormality of DNA repair (HP:0003254)1.60558066
164Distal lower limb amyotrophy (HP:0008944)1.60531696
165Melanoma (HP:0002861)1.57852176
166Back pain (HP:0003418)1.57469678
167Neoplasm of the adrenal gland (HP:0100631)1.56087888
168Rough bone trabeculation (HP:0100670)1.55415088
169Self-mutilation (HP:0000742)1.55321752
170Increased nuchal translucency (HP:0010880)1.55314061
171Ulnar bowing (HP:0003031)1.54858791
172Abnormality of the carotid arteries (HP:0005344)1.52710814
173Type 1 muscle fiber predominance (HP:0003803)1.52538691
174Elfin facies (HP:0004428)1.52468575

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.87412060
2SMG14.04379327
3PDK43.65549802
4PDK33.65549802
5TRIB33.65545469
6PKN23.62726126
7NEK13.01980802
8PDK22.95252409
9ICK2.95045326
10STK38L2.91171075
11ERN12.83282573
12BUB12.63035797
13FLT32.61945237
14CDC72.54230625
15VRK22.49155326
16TTN2.44813705
17SIK12.22509779
18CDK122.14364466
19LMTK22.05852547
20OBSCN2.05107335
21NEK91.82721790
22FGFR41.79285753
23PBK1.78652104
24PINK11.73023828
25INSRR1.69444363
26CDK81.67223275
27SRPK11.55837193
28MAP3K71.54162094
29PHKG21.52584367
30PHKG11.52584367
31NME11.51871443
32CDK71.40759824
33ATR1.37861868
34MAPK111.36342271
35CHEK21.33174468
36MAP2K31.30972894
37PIK3CA1.29800926
38TESK21.29620697
39MAPKAPK51.27698492
40MUSK1.27406514
41MYLK1.23654720
42ERBB41.18517691
43MAPKAPK31.14728779
44AURKA1.13753317
45MAP3K31.12380341
46PIM21.04634116
47TIE10.96659605
48CHEK10.96513201
49PLK10.95861509
50PRKAA20.95240379
51KDR0.95156549
52AURKB0.94023680
53SCYL20.92204928
54TAF10.88666711
55STK380.87499987
56MAP2K40.85779462
57BRSK10.84688330
58NEK20.83546880
59CDK40.81991120
60PTK60.81139241
61PRKAA10.79181537
62LATS20.77448450
63TLK10.76358292
64DMPK0.76200266
65MAP3K110.75508357
66EEF2K0.74406171
67PIK3CG0.73997894
68TTK0.72942982
69LATS10.72829540
70STK40.71809484
71ARAF0.71418235
72ZAK0.71044398
73PDPK10.68293632
74MELK0.68171807
75CCNB10.68107725
76NME20.67862353
77MAPK120.67792056
78EIF2AK10.67661016
79MAP3K50.67109662
80TYK20.66067098
81WNK40.65040840
82PAK40.63954964
83PDK10.63396948
84WEE10.62999789
85ABL20.62961895
86MAP2K10.60670458
87PRKCI0.60595281
88JAK20.60057571
89CDK20.57323234
90CDK10.56694277
91RAF10.56472983
92ILK0.54669740
93TAOK30.53883524
94DAPK10.53164084
95SGK30.52005477
96STK240.51934058
97MAP3K90.51208570
98LRRK20.50886876
99IRAK30.50245133
100PRKACG0.50080561
101ATM0.49428163
102PASK0.49342197
103MAP2K60.49125592
104EPHA20.48276274
105CDK90.47229210
106TGFBR10.46762010
107MTOR0.46735964
108TAOK10.43783505
109ACVR1B0.42394329
110MAP3K80.41922617
111RPS6KA50.41869006
112AKT20.41721546
113PRKD30.40273298
114PAK30.39276971
115MST1R0.38003593
116RPS6KB10.36236360
117BRAF0.35555905
118SIK20.35287047
119VRK10.32446038
120SGK20.32406401
121FER0.31874593
122PRKACB0.31316772
123RPS6KB20.30658480
124RIPK10.30586584
125TAOK20.29955054
126MAP2K20.29811654
127RPS6KA10.29665918
128CAMK2G0.29618384
129PRKD10.29221736
130MAPK140.28088797
131PAK20.27943183
132CSNK1E0.27774530
133CSNK2A20.26974871
134TSSK60.26648765
135PLK40.26210277
136CLK10.25653304
137CDK60.25270226
138PRPF4B0.25164741
139TGFBR20.24404945
140NUAK10.24378200
141MAPK40.23313248
142KSR20.23271365
143EIF2AK30.22710450
144PRKG20.22553672
145JAK10.22199176
146MAP3K100.21037560
147BRSK20.20753857
148GSK3A0.20198437
149DAPK30.20035961
150MET0.19603910

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.40508612
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.23781683
3Fatty acid degradation_Homo sapiens_hsa000713.20729723
4Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.18537410
52-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.08812895
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.06679397
7Propanoate metabolism_Homo sapiens_hsa006403.00023193
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.99957629
9Nitrogen metabolism_Homo sapiens_hsa009102.77223933
10Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.73418708
11Arginine biosynthesis_Homo sapiens_hsa002202.51634685
12Tryptophan metabolism_Homo sapiens_hsa003802.48048103
13Base excision repair_Homo sapiens_hsa034102.43562133
14Fatty acid metabolism_Homo sapiens_hsa012122.35189276
15Butanoate metabolism_Homo sapiens_hsa006502.30480807
16Carbon metabolism_Homo sapiens_hsa012002.21642540
17Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.21411622
18Pyruvate metabolism_Homo sapiens_hsa006202.19815151
19Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.14825109
20Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.07819429
21Peroxisome_Homo sapiens_hsa041461.96862318
22PPAR signaling pathway_Homo sapiens_hsa033201.95675987
23Nucleotide excision repair_Homo sapiens_hsa034201.94432444
24Pentose and glucuronate interconversions_Homo sapiens_hsa000401.84766566
25Ribosome_Homo sapiens_hsa030101.84370699
26Homologous recombination_Homo sapiens_hsa034401.81689257
27beta-Alanine metabolism_Homo sapiens_hsa004101.79733859
28Biosynthesis of amino acids_Homo sapiens_hsa012301.78044307
29Non-homologous end-joining_Homo sapiens_hsa034501.74842990
30Complement and coagulation cascades_Homo sapiens_hsa046101.73631895
31RNA polymerase_Homo sapiens_hsa030201.70839020
32Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.66991021
33Spliceosome_Homo sapiens_hsa030401.65403992
34RNA transport_Homo sapiens_hsa030131.63713998
35Selenocompound metabolism_Homo sapiens_hsa004501.63269348
36Cysteine and methionine metabolism_Homo sapiens_hsa002701.55616591
37Cell cycle_Homo sapiens_hsa041101.49294513
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.47678914
39Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.46789709
40Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.46675609
41Drug metabolism - other enzymes_Homo sapiens_hsa009831.45617973
42Starch and sucrose metabolism_Homo sapiens_hsa005001.43452724
43Fanconi anemia pathway_Homo sapiens_hsa034601.38757194
44Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.38310635
45Fatty acid elongation_Homo sapiens_hsa000621.35153850
46Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.32717683
47Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.31405284
48Chemical carcinogenesis_Homo sapiens_hsa052041.31164246
49Phenylalanine metabolism_Homo sapiens_hsa003601.29597540
50Folate biosynthesis_Homo sapiens_hsa007901.27373567
51Sulfur metabolism_Homo sapiens_hsa009201.26512019
52Histidine metabolism_Homo sapiens_hsa003401.19986789
53Tyrosine metabolism_Homo sapiens_hsa003501.16158975
54One carbon pool by folate_Homo sapiens_hsa006701.14741719
55Caffeine metabolism_Homo sapiens_hsa002321.12573833
56Bile secretion_Homo sapiens_hsa049761.09156003
57Steroid hormone biosynthesis_Homo sapiens_hsa001401.08666686
58Cyanoamino acid metabolism_Homo sapiens_hsa004601.07602904
59Retinol metabolism_Homo sapiens_hsa008301.04842425
60Arginine and proline metabolism_Homo sapiens_hsa003301.04353178
61Fat digestion and absorption_Homo sapiens_hsa049751.04089353
62Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.02489498
63N-Glycan biosynthesis_Homo sapiens_hsa005101.00934719
64Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.98480952
65Maturity onset diabetes of the young_Homo sapiens_hsa049500.96427751
66Sulfur relay system_Homo sapiens_hsa041220.93678889
67Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.93661056
68Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.93645507
69mRNA surveillance pathway_Homo sapiens_hsa030150.93641141
70Pentose phosphate pathway_Homo sapiens_hsa000300.92939499
71Lysine degradation_Homo sapiens_hsa003100.87394569
72Staphylococcus aureus infection_Homo sapiens_hsa051500.86469208
73Bladder cancer_Homo sapiens_hsa052190.82280639
74Vitamin B6 metabolism_Homo sapiens_hsa007500.81351925
75Glutathione metabolism_Homo sapiens_hsa004800.78865575
76RNA degradation_Homo sapiens_hsa030180.77518438
77Fructose and mannose metabolism_Homo sapiens_hsa000510.72466025
78ABC transporters_Homo sapiens_hsa020100.71245257
79Glycerolipid metabolism_Homo sapiens_hsa005610.70216062
80Galactose metabolism_Homo sapiens_hsa000520.67068344
81Fatty acid biosynthesis_Homo sapiens_hsa000610.63664284
82Metabolic pathways_Homo sapiens_hsa011000.59643410
83Vitamin digestion and absorption_Homo sapiens_hsa049770.57600916
84Parkinsons disease_Homo sapiens_hsa050120.53187603
85Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.53092996
86Glucagon signaling pathway_Homo sapiens_hsa049220.51030145
87Insulin resistance_Homo sapiens_hsa049310.50207166
88Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.49393645
89Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.48691183
90Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.48428229
91Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.47968477
92Oxidative phosphorylation_Homo sapiens_hsa001900.47775893
93Adipocytokine signaling pathway_Homo sapiens_hsa049200.42618282
94Basal transcription factors_Homo sapiens_hsa030220.40985947
95p53 signaling pathway_Homo sapiens_hsa041150.39945072
96Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.39055212
97AMPK signaling pathway_Homo sapiens_hsa041520.35892755
98Cardiac muscle contraction_Homo sapiens_hsa042600.35548171
99Oocyte meiosis_Homo sapiens_hsa041140.34565771
100Thyroid cancer_Homo sapiens_hsa052160.34151794
101Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.29755531
102Systemic lupus erythematosus_Homo sapiens_hsa053220.28482179
103* Viral carcinogenesis_Homo sapiens_hsa052030.26998448
104Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.25818264
105Insulin signaling pathway_Homo sapiens_hsa049100.25324621
106Steroid biosynthesis_Homo sapiens_hsa001000.23155181
107Huntingtons disease_Homo sapiens_hsa050160.22196252
108Alzheimers disease_Homo sapiens_hsa050100.21644731
109Chronic myeloid leukemia_Homo sapiens_hsa052200.18981314
110Epstein-Barr virus infection_Homo sapiens_hsa051690.18836233
111Central carbon metabolism in cancer_Homo sapiens_hsa052300.17972016
112Non-small cell lung cancer_Homo sapiens_hsa052230.17819694
113Glycerophospholipid metabolism_Homo sapiens_hsa005640.13080126
114Prion diseases_Homo sapiens_hsa050200.07497984
115Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.06003647
116Pyrimidine metabolism_Homo sapiens_hsa002400.04842760
117Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.03774179
118alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.03093665
119Dilated cardiomyopathy_Homo sapiens_hsa054140.01119918
120Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412-0.1116325
121Purine metabolism_Homo sapiens_hsa00230-0.1035467
122DNA replication_Homo sapiens_hsa03030-0.0882665
123Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0749209
124Mismatch repair_Homo sapiens_hsa03430-0.0709264
125Proteasome_Homo sapiens_hsa03050-0.0677451
126Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.0671761
127Linoleic acid metabolism_Homo sapiens_hsa00591-0.0560438
128Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.0177270

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