DNAJB11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a soluble glycoprotein of the endoplasmic reticulum (ER) lumen that functions as a co-chaperone of binding immunoglobulin protein, a 70 kilodalton heat shock protein chaperone required for the proper folding and assembly of proteins in the ER. The encoded protein contains a highly conserved J domain of about 70 amino acids with a characteristic His-Pro-Asp (HPD) motif and may regulate the activity of binding immunoglobulin protein by stimulating ATPase activity. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Golgi transport vesicle coating (GO:0048200)6.41503126
2COPI coating of Golgi vesicle (GO:0048205)6.41503126
3maintenance of protein localization in endoplasmic reticulum (GO:0035437)5.84969305
4protein retention in ER lumen (GO:0006621)5.06149877
5signal peptide processing (GO:0006465)4.67750693
6COPII vesicle coating (GO:0048208)4.55511022
7ribosome assembly (GO:0042255)4.38313123
8exocrine pancreas development (GO:0031017)4.24367396
9* activation of signaling protein activity involved in unfolded protein response (GO:0006987)4.17017414
10* positive regulation of nuclease activity (GO:0032075)4.11713426
11intestinal cholesterol absorption (GO:0030299)4.01505081
12nuclear pore complex assembly (GO:0051292)4.00152470
13* endoplasmic reticulum unfolded protein response (GO:0030968)3.90657118
14antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.88204922
15antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.88204922
16* regulation of nuclease activity (GO:0032069)3.79618181
17ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)3.79596390
18* cellular response to unfolded protein (GO:0034620)3.78934886
19establishment of integrated proviral latency (GO:0075713)3.73101471
20cysteine metabolic process (GO:0006534)3.68018241
21L-phenylalanine metabolic process (GO:0006558)3.66059451
22erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.66059451
234-hydroxyproline metabolic process (GO:0019471)3.65414539
24proteasome assembly (GO:0043248)3.63662405
25erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.61959271
26L-phenylalanine catabolic process (GO:0006559)3.61959271
27* cellular response to topologically incorrect protein (GO:0035967)3.58446569
28* ER-nucleus signaling pathway (GO:0006984)3.57325842
29valine metabolic process (GO:0006573)3.57108754
30sequestering of metal ion (GO:0051238)3.52695527
31establishment of viral latency (GO:0019043)3.45893922
32nuclear pore organization (GO:0006999)3.41607792
33protein maturation by protein folding (GO:0022417)3.40131420
34protein carboxylation (GO:0018214)3.37719286
35peptidyl-glutamic acid carboxylation (GO:0017187)3.37719286
36antigen processing and presentation of endogenous antigen (GO:0019883)3.35285792
37negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.33578100
38* response to endoplasmic reticulum stress (GO:0034976)3.29591572
39sulfur amino acid catabolic process (GO:0000098)3.26440692
40serine family amino acid biosynthetic process (GO:0009070)3.25538451
41mitotic chromosome condensation (GO:0007076)3.24750997
42cell adhesion mediated by integrin (GO:0033627)3.23865718
43retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.22488247
44formation of translation preinitiation complex (GO:0001731)3.21547212
45negative regulation of ligase activity (GO:0051352)3.20336637
46negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.20336637
47glycine metabolic process (GO:0006544)3.18047448
48regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.15724411
49protein N-linked glycosylation via asparagine (GO:0018279)3.14065267
50anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.12411753
51positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.11046205
52peptidyl-asparagine modification (GO:0018196)3.10972882
53UDP-N-acetylglucosamine metabolic process (GO:0006047)3.09233890
54folic acid-containing compound biosynthetic process (GO:0009396)3.09023260
55skin morphogenesis (GO:0043589)3.08616504
56regulation of vitamin D biosynthetic process (GO:0060556)3.08357696
57mitotic metaphase plate congression (GO:0007080)3.06539949
58pore complex assembly (GO:0046931)3.04553170
59aromatic amino acid family catabolic process (GO:0009074)3.02491793
60regulation of translational termination (GO:0006449)3.01405382
61negative regulation of fibrinolysis (GO:0051918)3.00897164
62nucleobase-containing small molecule interconversion (GO:0015949)2.96884919
63lysine metabolic process (GO:0006553)2.96865045
64lysine catabolic process (GO:0006554)2.96865045
65* response to unfolded protein (GO:0006986)2.96779216
66glyoxylate metabolic process (GO:0046487)2.91635760
67protein N-linked glycosylation (GO:0006487)2.89368923
68serine family amino acid metabolic process (GO:0009069)2.87928756
69antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.87224997
70* response to topologically incorrect protein (GO:0035966)2.86358059
71regulation of cellular amino acid metabolic process (GO:0006521)2.83802662
72regulation of vitamin metabolic process (GO:0030656)2.82458686
73homocysteine metabolic process (GO:0050667)2.80458114
74apoptotic cell clearance (GO:0043277)2.78685779
75pentose-phosphate shunt (GO:0006098)2.78014076
76ER overload response (GO:0006983)2.77603157
77regulation of protein activation cascade (GO:2000257)2.75049673
78vesicle coating (GO:0006901)2.74160290
79peptide catabolic process (GO:0043171)2.73338636
80regulation of translational fidelity (GO:0006450)2.71495705
81chaperone mediated protein folding requiring cofactor (GO:0051085)2.71385804
82mitotic sister chromatid segregation (GO:0000070)2.70598532
83antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.70505898
84peptidyl-proline hydroxylation (GO:0019511)2.70498868
85tetrahydrofolate metabolic process (GO:0046653)2.69456649
86L-serine metabolic process (GO:0006563)2.68605832
87alpha-linolenic acid metabolic process (GO:0036109)2.67403614
88signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.66388473
89intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.66388473
90tRNA aminoacylation for protein translation (GO:0006418)2.65323595
91regulation of complement activation (GO:0030449)2.64917046
92DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.64398805
93folic acid metabolic process (GO:0046655)2.64093620
94mitotic nuclear envelope disassembly (GO:0007077)2.63192092
95establishment of chromosome localization (GO:0051303)2.62786398
96de novo protein folding (GO:0006458)2.62724119
97positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.62684833
98metaphase plate congression (GO:0051310)2.62558266
99signal transduction involved in DNA integrity checkpoint (GO:0072401)2.62428658
100signal transduction involved in DNA damage checkpoint (GO:0072422)2.62428658
101complement activation, classical pathway (GO:0006958)2.61774451
102signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.60228618
103signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.60228618
104signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.60228618
105regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.59793738
106proline biosynthetic process (GO:0006561)2.59064075
107NADPH regeneration (GO:0006740)2.58010975
108DNA strand elongation involved in DNA replication (GO:0006271)2.56893861
109cellular modified amino acid catabolic process (GO:0042219)2.56163659
110tryptophan metabolic process (GO:0006568)2.55845328
111antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.55779727
112bile acid biosynthetic process (GO:0006699)2.55556407
113complement activation, alternative pathway (GO:0006957)2.55242687
114regulation of fibrinolysis (GO:0051917)2.55112098
115DNA strand elongation (GO:0022616)2.54637473
116regulation of RNA export from nucleus (GO:0046831)2.54324197
117protein localization to chromosome, centromeric region (GO:0071459)2.53860962
118intestinal absorption (GO:0050892)2.53855359
119signal transduction involved in cell cycle checkpoint (GO:0072395)2.53201251
120negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.52967936
121regulation of ubiquitin-protein transferase activity (GO:0051438)2.52281833
122amino acid activation (GO:0043038)2.51438591
123tRNA aminoacylation (GO:0043039)2.51438591
124de novo posttranslational protein folding (GO:0051084)2.51036321
125pinocytosis (GO:0006907)2.50385363
126one-carbon metabolic process (GO:0006730)2.50090770
127kynurenine metabolic process (GO:0070189)2.49676434
128cell redox homeostasis (GO:0045454)2.49620260
129glycosphingolipid catabolic process (GO:0046479)2.49094659
130protein autoprocessing (GO:0016540)2.49031247
131folic acid-containing compound metabolic process (GO:0006760)2.48736263
132fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.48711524
133positive regulation of ligase activity (GO:0051351)2.48498184
134membrane disassembly (GO:0030397)2.48002860
135nuclear envelope disassembly (GO:0051081)2.48002860
136Arp2/3 complex-mediated actin nucleation (GO:0034314)2.47782011
137triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.46847594
138ribosome biogenesis (GO:0042254)2.45675187
139tryptophan catabolic process (GO:0006569)2.45222287
140indole-containing compound catabolic process (GO:0042436)2.45222287
141indolalkylamine catabolic process (GO:0046218)2.45222287
142DNA unwinding involved in DNA replication (GO:0006268)2.44542568
143mitotic nuclear envelope reassembly (GO:0007084)2.44476831
144nuclear envelope reassembly (GO:0031468)2.44476831
145cellular copper ion homeostasis (GO:0006878)2.44452280
146tricarboxylic acid metabolic process (GO:0072350)2.43275241
147chaperone-mediated protein folding (GO:0061077)2.42094114
148protein localization to kinetochore (GO:0034501)2.41576934
149regulation of ligase activity (GO:0051340)2.40702674
150sister chromatid segregation (GO:0000819)2.40482645
151regulation of mitotic spindle organization (GO:0060236)2.40046713
152positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.39454971
153regulation of translation in response to stress (GO:0043555)2.39202814
154killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.38255033
155disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.38255033
156aromatic amino acid family metabolic process (GO:0009072)2.37114644
157cellular protein complex localization (GO:0034629)2.36442204
158complement activation (GO:0006956)2.35979843
159regulation of plasminogen activation (GO:0010755)2.35349892
160pteridine-containing compound biosynthetic process (GO:0042559)2.35273294
161glycolipid catabolic process (GO:0019377)2.35196661
162activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.33688295
163maternal placenta development (GO:0001893)2.33443781
164plasma lipoprotein particle clearance (GO:0034381)2.32390633
165urea cycle (GO:0000050)2.30509952
166urea metabolic process (GO:0019627)2.30509952
167GDP-mannose metabolic process (GO:0019673)2.30424073
168regulation of nucleobase-containing compound transport (GO:0032239)2.29882314
169telomere maintenance via semi-conservative replication (GO:0032201)2.29137433
170serine family amino acid catabolic process (GO:0009071)2.28623008
171transcytosis (GO:0045056)2.27788156
172fibrinolysis (GO:0042730)2.26942891
173nucleotide-sugar biosynthetic process (GO:0009226)2.26789658
174ER to Golgi vesicle-mediated transport (GO:0006888)2.23080139

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.79796568
2RXR_22158963_ChIP-Seq_LIVER_Mouse3.25638821
3PPARA_22158963_ChIP-Seq_LIVER_Mouse3.14606764
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.81943742
5IRF8_22096565_ChIP-ChIP_GC-B_Human2.65956218
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.65523409
7E2F7_22180533_ChIP-Seq_HELA_Human2.58904614
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.51432222
9HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.48578807
10MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.47238144
11LXR_22158963_ChIP-Seq_LIVER_Mouse2.44335907
12EGR1_19374776_ChIP-ChIP_THP-1_Human2.43932230
13ZNF263_19887448_ChIP-Seq_K562_Human2.38885894
14E2F4_17652178_ChIP-ChIP_JURKAT_Human2.20607794
15PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.20296700
16EGR1_23403033_ChIP-Seq_LIVER_Mouse2.13693365
17MYC_19079543_ChIP-ChIP_MESCs_Mouse2.13015109
18CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.08145468
19CLOCK_20551151_ChIP-Seq_293T_Human2.07071113
20GATA1_22025678_ChIP-Seq_K562_Human2.03034957
21SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.94437133
22GABP_17652178_ChIP-ChIP_JURKAT_Human1.91032034
23MYC_18555785_ChIP-Seq_MESCs_Mouse1.89153957
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.86071918
25NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.80560287
26NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.74098639
27CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.72982166
28PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.70390278
29KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.69650090
30* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.66693128
31* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.66573586
32TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.66069099
33DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.63494521
34SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.63331200
35HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.61509794
36FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.58901541
37MYC_22102868_ChIP-Seq_BL_Human1.58077569
38ELF1_17652178_ChIP-ChIP_JURKAT_Human1.55448427
39* CREB1_15753290_ChIP-ChIP_HEK293T_Human1.54780056
40RARG_19884340_ChIP-ChIP_MEFs_Mouse1.54453121
41CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.53924214
42FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.53728920
43STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.52878467
44AR_21909140_ChIP-Seq_LNCAP_Human1.50776655
45THAP11_20581084_ChIP-Seq_MESCs_Mouse1.50385951
46IRF8_21731497_ChIP-ChIP_J774_Mouse1.50207046
47MYB_21317192_ChIP-Seq_ERMYB_Mouse1.50039249
48POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.49857977
49NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.48078651
50NANOG_18555785_ChIP-Seq_MESCs_Mouse1.47923691
51STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.47532797
52* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.45843158
53KLF4_18555785_ChIP-Seq_MESCs_Mouse1.45444594
54* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.44475045
55MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.42029667
56BRD4_27068464_Chip-Seq_AML-cells_Mouse1.41363104
57IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.39534568
58ETS1_20019798_ChIP-Seq_JURKAT_Human1.39380737
59EST1_17652178_ChIP-ChIP_JURKAT_Human1.38609685
60TFEB_21752829_ChIP-Seq_HELA_Human1.38255068
61FOXM1_23109430_ChIP-Seq_U2OS_Human1.37746798
62TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.36212699
63SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.35587587
64RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.35388246
65* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.35047328
66MYC_18358816_ChIP-ChIP_MESCs_Mouse1.33398122
67VDR_21846776_ChIP-Seq_THP-1_Human1.33184493
68DCP1A_22483619_ChIP-Seq_HELA_Human1.32817871
69TP63_17297297_ChIP-ChIP_HaCaT_Human1.32026212
70* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.30719358
71ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.28625925
72TTF2_22483619_ChIP-Seq_HELA_Human1.28492999
73ERG_20887958_ChIP-Seq_HPC-7_Mouse1.26913089
74GABP_19822575_ChIP-Seq_HepG2_Human1.26543331
75* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.26364699
76* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.25794394
77NELFA_20434984_ChIP-Seq_ESCs_Mouse1.25048424
78ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.24985357
79ZFX_18555785_ChIP-Seq_MESCs_Mouse1.24407374
80IRF8_27001747_Chip-Seq_BMDM_Mouse1.23910826
81FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.23883821
82SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.23545666
83* SPI1_23547873_ChIP-Seq_NB4_Human1.23356703
84* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.22802223
85MYC_19030024_ChIP-ChIP_MESCs_Mouse1.22695658
86E2F1_18555785_ChIP-Seq_MESCs_Mouse1.22598542
87CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.22372001
88CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.22102478
89* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.21941576
90PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21200597
91VDR_23849224_ChIP-Seq_CD4+_Human1.20981851
92MYB_26560356_Chip-Seq_TH2_Human1.20063174
93KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.18018907
94TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16070804
95FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.14554897
96SOX2_27498859_Chip-Seq_STOMACH_Mouse1.13207865
97MYB_26560356_Chip-Seq_TH1_Human1.12195238
98XRN2_22483619_ChIP-Seq_HELA_Human1.11394309
99TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.11161247
100SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.10461025
101SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.10461025
102SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.10225807
103EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.09275078
104IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.07579246
105GATA4_25053715_ChIP-Seq_YYC3_Human1.07288250
106HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.06965103
107SRF_21415370_ChIP-Seq_HL-1_Mouse1.06958236
108TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.06899638
109SOX17_20123909_ChIP-Seq_XEN_Mouse1.06889518
110MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.06639784
111STAT4_19710469_ChIP-ChIP_TH1__Mouse1.06581923
112FOXP3_21729870_ChIP-Seq_TREG_Human1.06417824
113TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.05376654
114MAF_26560356_Chip-Seq_TH1_Human1.04122207
115* PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.04044131
116TRIM28_21343339_ChIP-Seq_HEK293_Human1.03997694
117E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.03540822
118KDM5A_27292631_Chip-Seq_BREAST_Human1.03462645
119POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.02645099
120ELK3_25401928_ChIP-Seq_HUVEC_Human1.02641885
121SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.02577326
122* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.02375118
123HIF1A_21447827_ChIP-Seq_MCF-7_Human1.02325127
124RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.01548038
125TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.00957855
126UTX_26944678_Chip-Seq_JUKART_Human1.00895010
127GATA6_25053715_ChIP-Seq_YYC3_Human1.00877311
128BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.00404019
129* ATF3_27146783_Chip-Seq_COLON_Human1.00088206
130* MYCN_18555785_ChIP-Seq_MESCs_Mouse0.98619668
131E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.98218672
132HOXB4_20404135_ChIP-ChIP_EML_Mouse0.98017613
133GATA1_22383799_ChIP-Seq_G1ME_Mouse0.97670364
134* VDR_24763502_ChIP-Seq_THP-1_Human0.97575409
135NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.97363352
136* STAT3_1855785_ChIP-Seq_MESCs_Mouse0.97324368
137E2F1_21310950_ChIP-Seq_MCF-7_Human0.97211360
138ELK1_19687146_ChIP-ChIP_HELA_Human0.97095316
139NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.96207300
140ELF5_23300383_ChIP-Seq_T47D_Human0.95326749
141CHD1_26751641_Chip-Seq_LNCaP_Human0.94151845

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system3.63870175
2MP0005360_urolithiasis3.29655073
3MP0005365_abnormal_bile_salt3.22911685
4MP0008438_abnormal_cutaneous_collagen2.78833219
5MP0001666_abnormal_nutrient_absorption2.68254439
6MP0005083_abnormal_biliary_tract2.61291818
7MP0005085_abnormal_gallbladder_physiolo2.53922599
8MP0003111_abnormal_nucleus_morphology2.53803464
9MP0003941_abnormal_skin_development2.47818250
10MP0009840_abnormal_foam_cell2.39266646
11MP0003806_abnormal_nucleotide_metabolis2.38082848
12MP0008007_abnormal_cellular_replicative2.37189549
13MP0005220_abnormal_exocrine_pancreas2.35027129
14MP0003705_abnormal_hypodermis_morpholog2.29859324
15MP0005058_abnormal_lysosome_morphology2.17620088
16MP0003077_abnormal_cell_cycle2.13922094
17MP0004272_abnormal_basement_membrane2.10959879
18MP0003252_abnormal_bile_duct2.08325015
19MP0006054_spinal_hemorrhage2.05685383
20MP0010094_abnormal_chromosome_stability2.03505106
21MP0003300_gastrointestinal_ulcer1.99041632
22MP0008932_abnormal_embryonic_tissue1.90169809
23MP0003693_abnormal_embryo_hatching1.82459578
24MP0001730_embryonic_growth_arrest1.78009690
25MP0005451_abnormal_body_composition1.73377219
26MP0008875_abnormal_xenobiotic_pharmacok1.70088409
27MP0009697_abnormal_copulation1.65751504
28MP0002796_impaired_skin_barrier1.59750646
29MP0009384_cardiac_valve_regurgitation1.59339425
30MP0004782_abnormal_surfactant_physiolog1.58661453
31MP0002138_abnormal_hepatobiliary_system1.55369567
32MP0005501_abnormal_skin_physiology1.52069444
33MP0003195_calcinosis1.51188725
34MP0000350_abnormal_cell_proliferation1.51102044
35MP0009643_abnormal_urine_homeostasis1.49734003
36MP0002877_abnormal_melanocyte_morpholog1.48386872
37MP0003186_abnormal_redox_activity1.46710569
38MP0004264_abnormal_extraembryonic_tissu1.45015021
39MP0003191_abnormal_cellular_cholesterol1.44904490
40MP0008058_abnormal_DNA_repair1.42941437
41MP0000609_abnormal_liver_physiology1.39764673
42MP0003868_abnormal_feces_composition1.39384574
43MP0005332_abnormal_amino_acid1.39382385
44MP0003453_abnormal_keratinocyte_physiol1.39076424
45MP0003566_abnormal_cell_adhesion1.38390381
46MP0003436_decreased_susceptibility_to1.38060608
47MP0010352_gastrointestinal_tract_polyps1.37350113
48MP0002254_reproductive_system_inflammat1.36011683
49MP0001727_abnormal_embryo_implantation1.34031140
50MP0001835_abnormal_antigen_presentation1.33601667
51MP0008260_abnormal_autophagy1.32977549
52MP0008057_abnormal_DNA_replication1.30196691
53MP0004233_abnormal_muscle_weight1.30038273
54MP0005023_abnormal_wound_healing1.27365654
55MP0003221_abnormal_cardiomyocyte_apopto1.27099308
56MP0010329_abnormal_lipoprotein_level1.24742974
57MP0003786_premature_aging1.23748481
58MP0003303_peritoneal_inflammation1.23114009
59MP0001216_abnormal_epidermal_layer1.22373985
60MP0005380_embryogenesis_phenotype1.22065811
61MP0001672_abnormal_embryogenesis/_devel1.22065811
62MP0002080_prenatal_lethality1.21562538
63MP0009333_abnormal_splenocyte_physiolog1.20805854
64MP0005319_abnormal_enzyme/_coenzyme1.20182901
65MP0006082_CNS_inflammation1.19773203
66MP0000685_abnormal_immune_system1.19441182
67MP0002693_abnormal_pancreas_physiology1.16248964
68MP0003984_embryonic_growth_retardation1.14680097
69MP0005621_abnormal_cell_physiology1.13490832
70MP0000598_abnormal_liver_morphology1.13205976
71MP0002086_abnormal_extraembryonic_tissu1.12789988
72MP0001697_abnormal_embryo_size1.12088305
73MP0001944_abnormal_pancreas_morphology1.10602154
74MP0003448_altered_tumor_morphology1.10506598
75MP0003172_abnormal_lysosome_physiology1.09379037
76MP0002088_abnormal_embryonic_growth/wei1.09047246
77MP0005275_abnormal_skin_tensile1.08591218
78MP0001845_abnormal_inflammatory_respons1.07723961
79MP0004947_skin_inflammation1.07006911
80MP0008469_abnormal_protein_level1.06483462
81MP0003950_abnormal_plasma_membrane1.05746371
82MP0005408_hypopigmentation1.00988375
83MP0001661_extended_life_span1.00481850
84MP0000313_abnormal_cell_death1.00281770
85MP0003091_abnormal_cell_migration0.99738353
86MP0001533_abnormal_skeleton_physiology0.99502430
87MP0005076_abnormal_cell_differentiation0.99382986
88MP0010234_abnormal_vibrissa_follicle0.98212426
89MP0005384_cellular_phenotype0.97214063
90MP0002166_altered_tumor_susceptibility0.96872177
91MP0010307_abnormal_tumor_latency0.96614996
92MP0009672_abnormal_birth_weight0.95017888
93MP0009785_altered_susceptibility_to0.94509043
94MP0005025_abnormal_response_to0.94450880
95MP0002419_abnormal_innate_immunity0.94231747
96MP0005464_abnormal_platelet_physiology0.94197569
97MP0001243_abnormal_dermal_layer0.93856816
98MP0010155_abnormal_intestine_physiology0.92776537
99MP0002118_abnormal_lipid_homeostasis0.92617268
100MP0001790_abnormal_immune_system0.92349051
101MP0005387_immune_system_phenotype0.92349051
102MP0004808_abnormal_hematopoietic_stem0.91383867
103MP0004957_abnormal_blastocyst_morpholog0.91149687
104MP0000627_abnormal_mammary_gland0.91007470
105MP0001881_abnormal_mammary_gland0.90334789
106MP0005623_abnormal_meninges_morphology0.89967135
107MP0000358_abnormal_cell_content/0.89956152
108MP0005000_abnormal_immune_tolerance0.88962805
109MP0001800_abnormal_humoral_immune0.87848177
110MP0000537_abnormal_urethra_morphology0.87523425
111MP0000858_altered_metastatic_potential0.86764750
112MP0002295_abnormal_pulmonary_circulatio0.86522222
113MP0003890_abnormal_embryonic-extraembry0.86153238
114MP0002452_abnormal_antigen_presenting0.84792301
115MP0002006_tumorigenesis0.84559797
116MP0002933_joint_inflammation0.84146759
117MP0005671_abnormal_response_to0.83599007
118MP0001849_ear_inflammation0.82650744
119MP0002405_respiratory_system_inflammati0.82442949
120MP0003656_abnormal_erythrocyte_physiolo0.82071714
121MP0003724_increased_susceptibility_to0.81418812
122MP0009763_increased_sensitivity_to0.81266320
123MP0000490_abnormal_crypts_of0.80590623
124MP0002396_abnormal_hematopoietic_system0.80361769
125MP0002148_abnormal_hypersensitivity_rea0.80210701
126MP0002723_abnormal_immune_serum0.80100440
127MP0001191_abnormal_skin_condition0.79971014
128MP0005636_abnormal_mineral_homeostasis0.79681184
129MP0005503_abnormal_tendon_morphology0.79673595
130MP0002060_abnormal_skin_morphology0.79458376
131MP0005197_abnormal_uvea_morphology0.78490360
132MP0001873_stomach_inflammation0.78360465
133MP0002084_abnormal_developmental_patter0.77952839
134MP0004185_abnormal_adipocyte_glucose0.77453412
135MP0002019_abnormal_tumor_incidence0.77388594
136MP0001756_abnormal_urination0.76324662
137MP0003795_abnormal_bone_structure0.76164362
138MP0000604_amyloidosis0.76116404
139MP0003718_maternal_effect0.75814983
140MP0002928_abnormal_bile_duct0.75747731
141MP0003279_aneurysm0.74641181
142MP0004197_abnormal_fetal_growth/weight/0.73524604
143MP0002136_abnormal_kidney_physiology0.73115181
144MP0005165_increased_susceptibility_to0.72845412
145MP0002420_abnormal_adaptive_immunity0.71639517
146MP0001764_abnormal_homeostasis0.71600195
147MP0005084_abnormal_gallbladder_morpholo0.71088901
148MP0001542_abnormal_bone_strength0.70800282
149MP0001819_abnormal_immune_cell0.70301019
150MP0002896_abnormal_bone_mineralization0.70066627
151MP0001958_emphysema0.70045973
152MP0000689_abnormal_spleen_morphology0.69449580
153MP0001915_intracranial_hemorrhage0.69039860
154MP0005257_abnormal_intraocular_pressure0.68789704
155MP0003763_abnormal_thymus_physiology0.67101369
156MP0001853_heart_inflammation0.66498150
157MP0009053_abnormal_anal_canal0.66374388

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the intrinsic pathway (HP:0010989)3.91461529
2Abnormality of aromatic amino acid family metabolism (HP:0004338)3.82458025
3Hypoglycemic coma (HP:0001325)3.78253473
4Abnormality of the common coagulation pathway (HP:0010990)3.68683952
5Deep venous thrombosis (HP:0002625)3.64262179
6Abnormality of monocarboxylic acid metabolism (HP:0010996)3.58033232
7Intrahepatic cholestasis (HP:0001406)3.41243021
8Vacuolated lymphocytes (HP:0001922)3.35433129
9Dysostosis multiplex (HP:0000943)3.30852132
10Tetraparesis (HP:0002273)3.21367753
11Fat malabsorption (HP:0002630)3.18356604
12Hypobetalipoproteinemia (HP:0003563)3.18044579
13Xanthomatosis (HP:0000991)3.06855746
14Urinary glycosaminoglycan excretion (HP:0003541)3.04594617
15Mucopolysacchariduria (HP:0008155)3.04594617
16Protrusio acetabuli (HP:0003179)3.04330942
17Premature rupture of membranes (HP:0001788)2.98750645
18Selective tooth agenesis (HP:0001592)2.87682711
19Steatorrhea (HP:0002570)2.82651314
20Multiple enchondromatosis (HP:0005701)2.82630766
21Cervical subluxation (HP:0003308)2.79657313
22Abnormality of glycolipid metabolism (HP:0010969)2.77941486
23Abnormality of liposaccharide metabolism (HP:0010968)2.77941486
24Abnormality of glycosphingolipid metabolism (HP:0004343)2.77941486
25Prolonged partial thromboplastin time (HP:0003645)2.70359800
26Trismus (HP:0000211)2.67553420
27Rough bone trabeculation (HP:0100670)2.65629372
28Abnormality of polysaccharide metabolism (HP:0011012)2.61816352
29Abnormality of glycosaminoglycan metabolism (HP:0004371)2.61816352
30Abnormality of mucopolysaccharide metabolism (HP:0011020)2.61816352
31Complement deficiency (HP:0004431)2.60526219
32Beaking of vertebral bodies (HP:0004568)2.57169823
33Atrophic scars (HP:0001075)2.56954281
34Ketosis (HP:0001946)2.56767460
35Increased serum pyruvate (HP:0003542)2.56737673
36Myocardial infarction (HP:0001658)2.55232363
37Microvesicular hepatic steatosis (HP:0001414)2.53955483
38Abnormality of glycolysis (HP:0004366)2.46955896
39Achilles tendon contracture (HP:0001771)2.46353025
40Abnormality of sulfur amino acid metabolism (HP:0004339)2.45648355
41Hypoglycemic seizures (HP:0002173)2.45581285
42Overlapping toe (HP:0001845)2.41577945
43Ketoacidosis (HP:0001993)2.39048633
44Deviation of the thumb (HP:0009603)2.36095337
45Abnormality of the Achilles tendon (HP:0005109)2.34729797
46Upper limb muscle weakness (HP:0003484)2.33997473
47Amniotic constriction ring (HP:0009775)2.32828226
48Abnormality of placental membranes (HP:0011409)2.32828226
49Hypolipoproteinemia (HP:0010981)2.32418596
50Progressive muscle weakness (HP:0003323)2.31170114
51Type I transferrin isoform profile (HP:0003642)2.31074191
52Peritonitis (HP:0002586)2.30548033
53Abnormal trabecular bone morphology (HP:0100671)2.29892891
54Cholecystitis (HP:0001082)2.27569009
55Abnormal gallbladder physiology (HP:0012438)2.27569009
56Sparse eyelashes (HP:0000653)2.26909901
57Abnormality of glutamine family amino acid metabolism (HP:0010902)2.25754358
58Hyperinsulinemic hypoglycemia (HP:0000825)2.24555890
59Abnormality of complement system (HP:0005339)2.22680464
60Recurrent gram-negative bacterial infections (HP:0005420)2.22676431
61Late onset (HP:0003584)2.22305732
62Abnormalities of placenta or umbilical cord (HP:0001194)2.21920649
63Orthostatic hypotension (HP:0001278)2.20744518
64Nonimmune hydrops fetalis (HP:0001790)2.19757358
65Generalized aminoaciduria (HP:0002909)2.17857776
66Aplastic anemia (HP:0001915)2.17456867
67Gout (HP:0001997)2.17094176
68Hyperammonemia (HP:0001987)2.16290300
69Proximal placement of thumb (HP:0009623)2.16276604
70Vertebral compression fractures (HP:0002953)2.16024532
71Abnormality of purine metabolism (HP:0004352)2.14826336
72Abnormality of transition element cation homeostasis (HP:0011030)2.14775114
73Secondary amenorrhea (HP:0000869)2.11223784
74Upper motor neuron abnormality (HP:0002127)2.10195450
75Insidious onset (HP:0003587)2.09037112
76Termporal pattern (HP:0011008)2.09037112
77Conjugated hyperbilirubinemia (HP:0002908)2.08251475
78Back pain (HP:0003418)2.06345501
79Joint hemorrhage (HP:0005261)2.06298577
80Joint stiffness (HP:0001387)2.06190393
81Abnormality of oral frenula (HP:0000190)2.05661839
82Eczematoid dermatitis (HP:0000976)2.03750653
83Interstitial pulmonary disease (HP:0006530)2.03743120
84Cardiovascular calcification (HP:0011915)2.02700970
85Systemic lupus erythematosus (HP:0002725)2.01242038
86Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.00763701
87Thrombocytosis (HP:0001894)2.00707691
88Abnormality of subcutaneous fat tissue (HP:0001001)1.99167239
89Menorrhagia (HP:0000132)1.98338756
90Hyperlipoproteinemia (HP:0010980)1.97603627
91Mitral stenosis (HP:0001718)1.97378327
92Abnormality of methionine metabolism (HP:0010901)1.97318758
93Entropion (HP:0000621)1.97033403
94Osteolytic defects of the phalanges of the hand (HP:0009771)1.96956744
95Osteolytic defects of the hand bones (HP:0009699)1.96956744
96Hyperglycinemia (HP:0002154)1.95582041
97Abnormality of the pancreatic islet cells (HP:0006476)1.94454219
98Abnormality of endocrine pancreas physiology (HP:0012093)1.94454219
99Abnormality of fatty-acid metabolism (HP:0004359)1.93284993
100Abnormality of dentin (HP:0010299)1.93270813
101Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.92101485
102Abnormality of the umbilical cord (HP:0010881)1.91982425
103Abnormality of aspartate family amino acid metabolism (HP:0010899)1.91518600
104Hepatocellular carcinoma (HP:0001402)1.89713342
105Abdominal distention (HP:0003270)1.88253715
106Vascular calcification (HP:0004934)1.87870571
107Abnormality of nucleobase metabolism (HP:0010932)1.87682828
108Esophageal varix (HP:0002040)1.87671256
109Impaired platelet aggregation (HP:0003540)1.86895747
110Abnormal platelet function (HP:0011869)1.86895747
111Protuberant abdomen (HP:0001538)1.86688593
112Spastic diplegia (HP:0001264)1.86075093
113Cortical dysplasia (HP:0002539)1.85798372
114Symptomatic seizures (HP:0011145)1.85746235
115Elbow flexion contracture (HP:0002987)1.85143514
116Abnormality of the distal phalanges of the toes (HP:0010182)1.84204193
117Abnormal cartilage morphology (HP:0002763)1.84108828
118Abnormal tarsal ossification (HP:0008369)1.83024795
119Hypoalphalipoproteinemia (HP:0003233)1.82187578
120Onycholysis (HP:0001806)1.81908681
121Abnormal foot bone ossification (HP:0010675)1.81836252
122Hypokinesia (HP:0002375)1.81659915
123Sensorimotor neuropathy (HP:0007141)1.80006702
124Skin nodule (HP:0200036)1.79848364
125Short nail (HP:0001799)1.78979866
126Abnormal protein glycosylation (HP:0012346)1.78336203
127Abnormal glycosylation (HP:0012345)1.78336203
128Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.78336203
129Abnormal protein N-linked glycosylation (HP:0012347)1.78336203
130Reduced antithrombin III activity (HP:0001976)1.78279534
131Biconcave vertebral bodies (HP:0004586)1.78190434
132Aortic aneurysm (HP:0004942)1.77724834
133Gingival bleeding (HP:0000225)1.77221366
134Lower limb hyperreflexia (HP:0002395)1.76916598
135Abnormal enzyme/coenzyme activity (HP:0012379)1.76626526
136Fragile skin (HP:0001030)1.74541770
137Degeneration of anterior horn cells (HP:0002398)1.74258030
138Abnormality of the anterior horn cell (HP:0006802)1.74258030
139Abnormality of iron homeostasis (HP:0011031)1.74216423
140Decreased subcutaneous fat (HP:0001002)1.72699091
141Spastic paraparesis (HP:0002313)1.72476784
142Abnormality of the acetabulum (HP:0003170)1.72315036
143Shoulder girdle muscle weakness (HP:0003547)1.71949843
144Pancreatitis (HP:0001733)1.71949835
145Progressive external ophthalmoplegia (HP:0000590)1.71613194
146Petechiae (HP:0000967)1.71257483
147Increased serum ferritin (HP:0003281)1.70480195
148Abnormality of glycine metabolism (HP:0010895)1.70211945
149Abnormality of serine family amino acid metabolism (HP:0010894)1.70211945
150Ankyloglossia (HP:0010296)1.70021175
151Small epiphyses (HP:0010585)1.69460256
152Oral leukoplakia (HP:0002745)1.67728116
153Congenital ichthyosiform erythroderma (HP:0007431)1.66829466
154Blepharitis (HP:0000498)1.66232469
155Blue sclerae (HP:0000592)1.64650476
156Fasciculations (HP:0002380)1.64395449
157Abnormal delivery (HP:0001787)1.62747761
158Hepatosplenomegaly (HP:0001433)1.62301298
159Ankle contracture (HP:0006466)1.61293721
160Bone pain (HP:0002653)1.61157441
161Progressive hearing impairment (HP:0001730)1.60510345
162Premature ovarian failure (HP:0008209)1.60298958
163Pelvic girdle muscle weakness (HP:0003749)1.60252544
164Abnormality of carpal bone ossification (HP:0006257)1.59434316
165Elevated alkaline phosphatase (HP:0003155)1.58464869
166Pseudobulbar signs (HP:0002200)1.57739077
167Flat acetabular roof (HP:0003180)1.56639678
168Increased nuchal translucency (HP:0010880)1.55904042
169Right ventricular cardiomyopathy (HP:0011663)1.55557767
170Loss of speech (HP:0002371)1.54775197
171Pterygium (HP:0001059)1.54743271

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN15.11420319
2EIF2AK13.01063074
3BCKDK2.87765688
4TRIB32.80361980
5EIF2AK32.60258006
6NME22.56328357
7TSSK62.51878370
8FLT32.39582805
9PKN22.19876620
10RPS6KA41.97587550
11NEK11.93241201
12PDK21.93002715
13TTK1.88144934
14KDR1.87109070
15TAOK31.85237422
16CDK121.80869462
17ZAP701.76612247
18MAP4K11.75226524
19SCYL21.71739338
20FGFR41.71697051
21JAK31.58656446
22STK101.53812362
23TESK21.52915057
24TBK11.52655982
25PTK61.50882349
26LATS21.49862006
27SIK11.47747610
28MAP3K31.46649549
29FRK1.45296743
30SIK31.42228861
31MAP3K121.40515112
32EPHB11.39988111
33SMG11.38300847
34PASK1.34165830
35TYK21.33900017
36VRK21.33456240
37LRRK21.31362495
38TESK11.29217174
39MAP3K101.28232819
40MET1.24628491
41NEK91.22097434
42BLK1.21327375
43PIM21.20581002
44IRAK41.16847240
45ARAF1.06788430
46BUB11.05159320
47PDGFRA1.04084217
48PAK41.02997392
49JAK11.01444242
50PLK31.00827244
51LIMK10.97507857
52MOS0.97306526
53STK160.97059033
54PRPF4B0.96150268
55MKNK10.95786005
56MAP3K80.95611021
57EPHA20.94645829
58IRAK30.94156007
59CSK0.91533836
60KIT0.90965648
61BCR0.90459637
62TAOK20.90048243
63BTK0.87404340
64MAP2K30.86712758
65CSF1R0.86504360
66INSRR0.86367201
67ALK0.84346875
68NEK20.84047132
69BRSK10.82829827
70EPHA30.82822177
71CLK10.81662643
72TTN0.80833889
73TAF10.80444562
74PTK20.79708591
75STK30.79494307
76MST1R0.78234715
77LATS10.77487782
78PLK10.77361297
79PAK20.77162511
80CHEK10.76837320
81PIK3CG0.76550395
82EEF2K0.76480943
83IKBKE0.75913588
84CDK90.75681465
85TGFBR20.74756478
86MST40.74631772
87WEE10.74088755
88ITK0.73685476
89BRSK20.72060790
90MAP2K20.70044491
91EIF2AK20.69330724
92MAP3K110.67904165
93CDC70.65855293
94JAK20.65505972
95MKNK20.64933282
96BRD40.64735612
97MAP3K140.61078369
98ATR0.61050734
99BRAF0.61010069
100NME10.60821441
101AURKA0.59600266
102PIM10.57169217
103DDR20.57067757
104RIPK10.55727454
105MAP3K50.54416159
106ILK0.54264958
107CHEK20.54096757
108CDK80.53842017
109STK240.53330859
110MTOR0.52620005
111DMPK0.51271535
112TRIM280.50462047
113LYN0.49808425
114ERBB30.49632398
115IKBKB0.49551215
116CDK40.48453515
117CDK60.48429069
118NUAK10.48308739
119PDGFRB0.48255120
120FGFR30.47674047
121YES10.47091878
122CHUK0.46941257
123ABL20.46899713
124CSNK2A20.46615910
125ICK0.46345666
126CSNK2A10.46088629
127PLK40.45691375
128MAPKAPK30.44534688
129LCK0.43512752
130DYRK1B0.43174018
131AURKB0.42962488
132TGFBR10.42589660
133MAPK150.42309357
134RPS6KB20.42289643
135SRPK10.42274113
136TEC0.41818592
137ERBB40.40721585
138HIPK20.39755756
139STK40.38613263
140PBK0.38370295
141IRAK10.38163315
142IRAK20.38028774
143SYK0.37638730
144CDK70.37080284
145MAPK110.36971093
146MELK0.36875075
147NTRK10.32681657
148MAPKAPK20.31118089

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030603.77579029
2* Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.95877214
3Maturity onset diabetes of the young_Homo sapiens_hsa049502.74380499
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.56021924
5Primary bile acid biosynthesis_Homo sapiens_hsa001202.48539084
6Spliceosome_Homo sapiens_hsa030402.34947529
7Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.22826603
8Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.17643740
9Folate biosynthesis_Homo sapiens_hsa007902.11381444
10Selenocompound metabolism_Homo sapiens_hsa004502.10729458
11Sulfur metabolism_Homo sapiens_hsa009202.01922473
12Mismatch repair_Homo sapiens_hsa034301.97837100
13Complement and coagulation cascades_Homo sapiens_hsa046101.77900595
14Tryptophan metabolism_Homo sapiens_hsa003801.77494903
15N-Glycan biosynthesis_Homo sapiens_hsa005101.72265282
16Pentose and glucuronate interconversions_Homo sapiens_hsa000401.71087077
17Fat digestion and absorption_Homo sapiens_hsa049751.69742358
18Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.69254518
19Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.68400452
20Non-homologous end-joining_Homo sapiens_hsa034501.65685367
21Base excision repair_Homo sapiens_hsa034101.65197380
22Cell cycle_Homo sapiens_hsa041101.60296032
23Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.58826589
24Other glycan degradation_Homo sapiens_hsa005111.57789358
25Antigen processing and presentation_Homo sapiens_hsa046121.55289611
26One carbon pool by folate_Homo sapiens_hsa006701.52991623
27Fatty acid degradation_Homo sapiens_hsa000711.51555002
28Staphylococcus aureus infection_Homo sapiens_hsa051501.42007560
29Nitrogen metabolism_Homo sapiens_hsa009101.41783873
30Glycosaminoglycan degradation_Homo sapiens_hsa005311.40538942
31Drug metabolism - other enzymes_Homo sapiens_hsa009831.38069165
32Nucleotide excision repair_Homo sapiens_hsa034201.33595571
33Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.27623015
34Proteasome_Homo sapiens_hsa030501.27492481
35Lysosome_Homo sapiens_hsa041421.27155169
36Histidine metabolism_Homo sapiens_hsa003401.26096793
37Vibrio cholerae infection_Homo sapiens_hsa051101.25016097
38Arginine biosynthesis_Homo sapiens_hsa002201.15784812
39Caffeine metabolism_Homo sapiens_hsa002321.15725548
40Peroxisome_Homo sapiens_hsa041461.13817686
41RNA polymerase_Homo sapiens_hsa030201.11772386
42Sulfur relay system_Homo sapiens_hsa041221.11644477
43Protein digestion and absorption_Homo sapiens_hsa049741.11569977
44mRNA surveillance pathway_Homo sapiens_hsa030151.10849205
45Starch and sucrose metabolism_Homo sapiens_hsa005001.08379700
46Fructose and mannose metabolism_Homo sapiens_hsa000511.07976042
47Biosynthesis of amino acids_Homo sapiens_hsa012301.07369454
48Cysteine and methionine metabolism_Homo sapiens_hsa002701.06164335
49Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.03808715
50Renin-angiotensin system_Homo sapiens_hsa046141.02185625
51Steroid biosynthesis_Homo sapiens_hsa001001.00792441
52Legionellosis_Homo sapiens_hsa051341.00379723
53Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.99921999
54Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.99890616
55Vitamin digestion and absorption_Homo sapiens_hsa049770.99249409
56Epstein-Barr virus infection_Homo sapiens_hsa051690.98356089
57Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.97749112
58Fatty acid elongation_Homo sapiens_hsa000620.96078345
59Arginine and proline metabolism_Homo sapiens_hsa003300.95288809
60Pentose phosphate pathway_Homo sapiens_hsa000300.94390968
61Thyroid cancer_Homo sapiens_hsa052160.92303895
62Propanoate metabolism_Homo sapiens_hsa006400.90300314
63Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.89750669
64Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.89227310
65Carbon metabolism_Homo sapiens_hsa012000.88735571
66Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.88008494
67Sphingolipid metabolism_Homo sapiens_hsa006000.87792790
68Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.86893071
692-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.84602349
70Glutathione metabolism_Homo sapiens_hsa004800.82335877
71Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.81040727
72Salmonella infection_Homo sapiens_hsa051320.81016506
73Chemical carcinogenesis_Homo sapiens_hsa052040.80476342
74beta-Alanine metabolism_Homo sapiens_hsa004100.79185838
75Vitamin B6 metabolism_Homo sapiens_hsa007500.78821003
76Herpes simplex infection_Homo sapiens_hsa051680.78319908
77Galactose metabolism_Homo sapiens_hsa000520.78312140
78Pancreatic secretion_Homo sapiens_hsa049720.76900380
79Cyanoamino acid metabolism_Homo sapiens_hsa004600.75996241
80Basal transcription factors_Homo sapiens_hsa030220.75660935
81Central carbon metabolism in cancer_Homo sapiens_hsa052300.74117236
82Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.73848153
83Fatty acid metabolism_Homo sapiens_hsa012120.71124822
84Pyruvate metabolism_Homo sapiens_hsa006200.70009138
85Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.68689989
86Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.66836042
87RNA degradation_Homo sapiens_hsa030180.65059012
88Chronic myeloid leukemia_Homo sapiens_hsa052200.64322607
89Hepatitis B_Homo sapiens_hsa051610.64244347
90Phenylalanine metabolism_Homo sapiens_hsa003600.62905462
91Pancreatic cancer_Homo sapiens_hsa052120.62244396
92PPAR signaling pathway_Homo sapiens_hsa033200.61590821
93Butanoate metabolism_Homo sapiens_hsa006500.58810022
94Leishmaniasis_Homo sapiens_hsa051400.57204838
95Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.55797604
96Homologous recombination_Homo sapiens_hsa034400.55331079
97Steroid hormone biosynthesis_Homo sapiens_hsa001400.54864638
98DNA replication_Homo sapiens_hsa030300.54667141
99Glycerolipid metabolism_Homo sapiens_hsa005610.54429221
100NF-kappa B signaling pathway_Homo sapiens_hsa040640.54179076
101Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.51232406
102Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.51202179
103Tyrosine metabolism_Homo sapiens_hsa003500.51161774
104Influenza A_Homo sapiens_hsa051640.50713199
105Apoptosis_Homo sapiens_hsa042100.50007514
106Rheumatoid arthritis_Homo sapiens_hsa053230.48853294
107Malaria_Homo sapiens_hsa051440.48680039
108p53 signaling pathway_Homo sapiens_hsa041150.48567846
109Retinol metabolism_Homo sapiens_hsa008300.48147616
110ABC transporters_Homo sapiens_hsa020100.47720878
111Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.47143587
112HTLV-I infection_Homo sapiens_hsa051660.45457565
113Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.45046905
114Leukocyte transendothelial migration_Homo sapiens_hsa046700.44602156
115TNF signaling pathway_Homo sapiens_hsa046680.44208904
116Shigellosis_Homo sapiens_hsa051310.43291073
117Pyrimidine metabolism_Homo sapiens_hsa002400.42124832
118Prostate cancer_Homo sapiens_hsa052150.41880405
119Proteoglycans in cancer_Homo sapiens_hsa052050.41687459
120Viral carcinogenesis_Homo sapiens_hsa052030.40974459
121Primary immunodeficiency_Homo sapiens_hsa053400.40396667
122Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.40216929
123Measles_Homo sapiens_hsa051620.40151107
124Prion diseases_Homo sapiens_hsa050200.40041664
125Lysine degradation_Homo sapiens_hsa003100.38574383
126Hepatitis C_Homo sapiens_hsa051600.38400704
127Toll-like receptor signaling pathway_Homo sapiens_hsa046200.38224849
128RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.37796171
129Metabolic pathways_Homo sapiens_hsa011000.37717035
130Bladder cancer_Homo sapiens_hsa052190.37676959
131MicroRNAs in cancer_Homo sapiens_hsa052060.37615870
132Small cell lung cancer_Homo sapiens_hsa052220.36751783
133Amoebiasis_Homo sapiens_hsa051460.36559217
134Bile secretion_Homo sapiens_hsa049760.35397099
135Phagosome_Homo sapiens_hsa041450.34770176
136TGF-beta signaling pathway_Homo sapiens_hsa043500.34445739
137Adherens junction_Homo sapiens_hsa045200.34293542
138RNA transport_Homo sapiens_hsa030130.34185716
139Pertussis_Homo sapiens_hsa051330.33299663
140Intestinal immune network for IgA production_Homo sapiens_hsa046720.32801021
141Insulin resistance_Homo sapiens_hsa049310.32641545
142Viral myocarditis_Homo sapiens_hsa054160.32259924
143Fanconi anemia pathway_Homo sapiens_hsa034600.30539340

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