DNAJB12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: DNAJB12 belongs to the evolutionarily conserved DNAJ/HSP40 family of proteins, which regulate molecular chaperone activity by stimulating ATPase activity. DNAJ proteins may have up to 3 distinct domains: a conserved 70-amino acid J domain, usually at the N terminus; a glycine/phenylalanine (G/F)-rich region; and a cysteine-rich domain containing 4 motifs resembling a zinc finger domain (Ohtsuka and Hata, 2000 [PubMed 11147971]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.13093053
2L-phenylalanine catabolic process (GO:0006559)6.13093053
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.94629934
4L-phenylalanine metabolic process (GO:0006558)5.94629934
5aromatic amino acid family catabolic process (GO:0009074)5.41520093
6glyoxylate metabolic process (GO:0046487)4.99846792
7sulfur amino acid catabolic process (GO:0000098)4.90477824
8cysteine metabolic process (GO:0006534)4.86094350
9alpha-linolenic acid metabolic process (GO:0036109)4.84397528
10triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.79757406
11fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.74477140
12bile acid biosynthetic process (GO:0006699)4.73128882
13tryptophan catabolic process (GO:0006569)4.69804095
14indole-containing compound catabolic process (GO:0042436)4.69804095
15indolalkylamine catabolic process (GO:0046218)4.69804095
16kynurenine metabolic process (GO:0070189)4.58340156
17response to peptidoglycan (GO:0032494)4.55662363
18lysine catabolic process (GO:0006554)4.52408464
19lysine metabolic process (GO:0006553)4.52408464
20peptidyl-glutamic acid carboxylation (GO:0017187)4.44837724
21protein carboxylation (GO:0018214)4.44837724
22tryptophan metabolic process (GO:0006568)4.41754870
23high-density lipoprotein particle remodeling (GO:0034375)4.41154102
24urea cycle (GO:0000050)4.31973604
25urea metabolic process (GO:0019627)4.31973604
26negative regulation of fibrinolysis (GO:0051918)4.30241390
27regulation of cholesterol esterification (GO:0010872)4.19129019
28serine family amino acid catabolic process (GO:0009071)4.17561638
29amino-acid betaine metabolic process (GO:0006577)4.12015205
30bile acid metabolic process (GO:0008206)4.08472632
31nitrogen cycle metabolic process (GO:0071941)3.96687203
32homocysteine metabolic process (GO:0050667)3.94663926
33serine family amino acid biosynthetic process (GO:0009070)3.91691707
34plasma lipoprotein particle clearance (GO:0034381)3.91042226
35cellular modified amino acid catabolic process (GO:0042219)3.89825722
36regulation of triglyceride catabolic process (GO:0010896)3.89768069
37reverse cholesterol transport (GO:0043691)3.89582151
38plasma lipoprotein particle remodeling (GO:0034369)3.87584501
39protein-lipid complex remodeling (GO:0034368)3.87584501
40macromolecular complex remodeling (GO:0034367)3.87584501
41serine family amino acid metabolic process (GO:0009069)3.83157858
42complement activation, alternative pathway (GO:0006957)3.81381683
43aromatic amino acid family metabolic process (GO:0009072)3.80925168
44regulation of fibrinolysis (GO:0051917)3.80100368
45alpha-amino acid catabolic process (GO:1901606)3.74481988
46phospholipid efflux (GO:0033700)3.72519043
47regulation of cholesterol homeostasis (GO:2000188)3.71624664
48positive regulation by symbiont of host defense response (GO:0052509)3.68886537
49modulation by symbiont of host defense response (GO:0052031)3.68886537
50modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.68886537
51modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.68886537
52positive regulation by organism of defense response of other organism involved in symbiotic interact3.68886537
53modulation by symbiont of host immune response (GO:0052553)3.68886537
54fatty acid beta-oxidation (GO:0006635)3.67513692
55barbed-end actin filament capping (GO:0051016)3.65867473
56glycine metabolic process (GO:0006544)3.64706436
57regulation of cholesterol metabolic process (GO:0090181)3.64251445
582-oxoglutarate metabolic process (GO:0006103)3.63579141
59cellular glucuronidation (GO:0052695)3.63468757
60negative regulation of erythrocyte differentiation (GO:0045647)3.61445295
61regulation of protein activation cascade (GO:2000257)3.61107281
62phospholipid homeostasis (GO:0055091)3.60060262
63cellular amino acid catabolic process (GO:0009063)3.59699977
64valine metabolic process (GO:0006573)3.59284271
65negative regulation of sterol transport (GO:0032372)3.58306160
66negative regulation of cholesterol transport (GO:0032375)3.58306160
67acylglycerol homeostasis (GO:0055090)3.52179605
68triglyceride homeostasis (GO:0070328)3.52179605
69low-density lipoprotein particle remodeling (GO:0034374)3.51167109
70fatty acid oxidation (GO:0019395)3.50121386
71drug transmembrane transport (GO:0006855)3.50081294
72cholesterol efflux (GO:0033344)3.50075826
73negative regulation of interleukin-12 production (GO:0032695)3.48584726
74regulation of cholesterol biosynthetic process (GO:0045540)3.48242181
75short-chain fatty acid metabolic process (GO:0046459)3.47629132
76aspartate family amino acid catabolic process (GO:0009068)3.45986047
77positive regulation of lipoprotein lipase activity (GO:0051006)3.45972826
78positive regulation of triglyceride lipase activity (GO:0061365)3.45972826
79lipid oxidation (GO:0034440)3.44646437
80tyrosine metabolic process (GO:0006570)3.44590958
81acetyl-CoA metabolic process (GO:0006084)3.40928048
82monocarboxylic acid catabolic process (GO:0072329)3.36111617
83regulation of complement activation (GO:0030449)3.36017729
84fatty acid catabolic process (GO:0009062)3.35573695
85carnitine metabolic process (GO:0009437)3.35192223
86very-low-density lipoprotein particle assembly (GO:0034379)3.33426592
87NIK/NF-kappaB signaling (GO:0038061)3.32704434
88cellular ketone body metabolic process (GO:0046950)3.32495068
89negative regulation of cell killing (GO:0031342)3.32166599
90negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.32166599
91organic acid catabolic process (GO:0016054)3.31315607
92carboxylic acid catabolic process (GO:0046395)3.31315607
93cholesterol homeostasis (GO:0042632)3.31037337
94plasma lipoprotein particle assembly (GO:0034377)3.29451881
95response to mercury ion (GO:0046689)3.28877774
96uronic acid metabolic process (GO:0006063)3.28625643
97glucuronate metabolic process (GO:0019585)3.28625643
98lipopolysaccharide-mediated signaling pathway (GO:0031663)3.27813666
99macrophage activation involved in immune response (GO:0002281)3.27774763
100sterol homeostasis (GO:0055092)3.27460592
101coenzyme catabolic process (GO:0009109)3.27361169
102urate metabolic process (GO:0046415)3.26581340
103protein-lipid complex assembly (GO:0065005)3.25288502
104amine catabolic process (GO:0009310)3.25174869
105cellular biogenic amine catabolic process (GO:0042402)3.25174869
106glutamate metabolic process (GO:0006536)3.25071544
107bile acid and bile salt transport (GO:0015721)3.24302346
108ethanol oxidation (GO:0006069)3.24240152
109neutrophil activation involved in immune response (GO:0002283)3.23792649
110intestinal cholesterol absorption (GO:0030299)3.22709392
111drug catabolic process (GO:0042737)3.21514983
112lipoprotein metabolic process (GO:0042157)3.20941455
113response to nitrosative stress (GO:0051409)3.20004149
114positive regulation of lipid catabolic process (GO:0050996)3.19209538
115positive regulation of fatty acid beta-oxidation (GO:0032000)3.18137174
116immunoglobulin mediated immune response (GO:0016064)3.14855311
117benzene-containing compound metabolic process (GO:0042537)3.14011808
118pyrimidine-containing compound salvage (GO:0008655)3.12253401
119pyrimidine nucleoside salvage (GO:0043097)3.12253401
120response to muramyl dipeptide (GO:0032495)3.08732649
121negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.07468915
122detection of molecule of bacterial origin (GO:0032490)3.07128805
123positive regulation of Cdc42 GTPase activity (GO:0043089)3.05162433
124detection of other organism (GO:0098543)3.04596306
125antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.00426971
126pinocytosis (GO:0006907)2.98175399
127cellular extravasation (GO:0045123)2.96705932
128glycosphingolipid catabolic process (GO:0046479)2.95453106
129protein localization to endosome (GO:0036010)2.94551411
130mannose metabolic process (GO:0006013)2.93154876
131antigen processing and presentation of endogenous antigen (GO:0019883)2.91741337
132detection of bacterium (GO:0016045)2.88979440
133regulation of T-helper 2 cell differentiation (GO:0045628)2.87403633
134detection of external biotic stimulus (GO:0098581)2.86074572
135positive regulation of gamma-delta T cell activation (GO:0046645)2.81368108
136positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.80779573
137regulation of leukocyte degranulation (GO:0043300)2.79755946
138response to type I interferon (GO:0034340)2.79428132
139positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.78481762
140type I interferon signaling pathway (GO:0060337)2.77311734
141cellular response to type I interferon (GO:0071357)2.77311734
142antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.77014768
143glycolipid catabolic process (GO:0019377)2.74814348
144antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.71081300
145regulation of interferon-beta biosynthetic process (GO:0045357)2.69538753
146stress fiber assembly (GO:0043149)2.69288734
147regulation of mast cell degranulation (GO:0043304)2.68642598
148germinal center formation (GO:0002467)2.67734722
149low-density lipoprotein particle clearance (GO:0034383)2.66263616
150regulation of vitamin D biosynthetic process (GO:0060556)2.65237338
151COPI coating of Golgi vesicle (GO:0048205)2.64053671
152Golgi transport vesicle coating (GO:0048200)2.64053671
153oligosaccharide catabolic process (GO:0009313)2.63022103
154regulation of myeloid leukocyte mediated immunity (GO:0002886)2.61750988
155regulation of dendritic cell antigen processing and presentation (GO:0002604)2.60837244
156regulation of necrotic cell death (GO:0010939)2.60096559
157positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.58548072
158regulation of apoptotic process involved in morphogenesis (GO:1902337)2.57757144
159regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.57421233
160regulation of type I interferon-mediated signaling pathway (GO:0060338)2.57273740
161regulation of necroptotic process (GO:0060544)2.56274447
162amino sugar catabolic process (GO:0046348)2.55060742
163modulation by symbiont of host cellular process (GO:0044068)2.54135446
164response to host (GO:0075136)2.53868160
165response to host defenses (GO:0052200)2.53868160
166response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.53868160
167response to laminar fluid shear stress (GO:0034616)2.52355343
168macrophage activation (GO:0042116)2.52158026
169negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.49012968
170regulation of superoxide anion generation (GO:0032928)2.48716058
171response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.48660502
172response to host immune response (GO:0052572)2.48660502
173N-acetylneuraminate metabolic process (GO:0006054)2.46355050
174positive regulation of tumor necrosis factor production (GO:0032760)2.44585500
175cellular response to arsenic-containing substance (GO:0071243)2.44335004
176positive regulation of macrophage differentiation (GO:0045651)2.44129806
177granulocyte activation (GO:0036230)2.42481068
178detection of biotic stimulus (GO:0009595)2.42323411
179positive regulation of cellular amide metabolic process (GO:0034250)2.42205044
180regulation of tumor necrosis factor superfamily cytokine production (GO:1903555)2.41756507
181negative regulation of innate immune response (GO:0045824)2.40784050
182cellular response to thyroid hormone stimulus (GO:0097067)2.40391943
183response to progesterone (GO:0032570)2.39541174
184interferon-gamma secretion (GO:0072643)2.38613122
185regulation of chemokine biosynthetic process (GO:0045073)2.38576301
186positive regulation of chemokine biosynthetic process (GO:0045080)2.37321629
187myeloid cell activation involved in immune response (GO:0002275)2.36464017
188positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.36435521
189regulation of membrane protein ectodomain proteolysis (GO:0051043)2.36063176
190mature B cell differentiation involved in immune response (GO:0002313)2.35725201
191myeloid dendritic cell differentiation (GO:0043011)2.35247931
192response to thyroid hormone (GO:0097066)2.34626751
193positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.34236416
194pentose-phosphate shunt (GO:0006098)2.34176785
195GDP-mannose metabolic process (GO:0019673)2.34099583
196regulation of tumor necrosis factor production (GO:0032680)2.33341751
197hyaluronan catabolic process (GO:0030214)2.33023532
198interferon-gamma-mediated signaling pathway (GO:0060333)2.32808641
199regulation of vitamin metabolic process (GO:0030656)2.32307166
200positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.31773425

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.72374637
2* RXR_22158963_ChIP-Seq_LIVER_Mouse6.29917966
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse5.71761841
4LXR_22158963_ChIP-Seq_LIVER_Mouse5.10193092
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.34202173
6EGR1_23403033_ChIP-Seq_LIVER_Mouse4.31369058
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.13311033
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.76995988
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.13007811
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.96714768
11* VDR_21846776_ChIP-Seq_THP-1_Human2.96292403
12TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.58662812
13RARG_19884340_ChIP-ChIP_MEFs_Mouse2.22583136
14* VDR_24763502_ChIP-Seq_THP-1_Human2.20153163
15BP1_19119308_ChIP-ChIP_Hs578T_Human2.05355078
16EGR1_19374776_ChIP-ChIP_THP-1_Human1.98855380
17IRF8_22096565_ChIP-ChIP_GC-B_Human1.95600687
18* MYC_22102868_ChIP-Seq_BL_Human1.94537864
19CLOCK_20551151_ChIP-Seq_293T_Human1.94437226
20* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.92020149
21MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.88355660
22STAT6_21828071_ChIP-Seq_BEAS2B_Human1.82122788
23THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.77722399
24FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.76408665
25* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.73432809
26* KDM2B_26808549_Chip-Seq_DND41_Human1.67339254
27STAT4_19710469_ChIP-ChIP_TH1__Mouse1.65690174
28SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.63508330
29RUNX1_22412390_ChIP-Seq_EML_Mouse1.62026499
30SOX2_27498859_Chip-Seq_STOMACH_Mouse1.59407633
31STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.56484397
32RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.52449968
33HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.51232905
34STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.49201911
35NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.49120627
36UTX_26944678_Chip-Seq_JUKART_Human1.46878780
37SPI1_23127762_ChIP-Seq_K562_Human1.43697970
38DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.43677392
39MAF_26560356_Chip-Seq_TH2_Human1.41408318
40FOXA2_19822575_ChIP-Seq_HepG2_Human1.41368194
41EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.40303297
42SPI1_23547873_ChIP-Seq_NB4_Human1.38790922
43TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.37902516
44PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.33839911
45GATA1_22025678_ChIP-Seq_K562_Human1.32653408
46CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.31374295
47MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.30884609
48* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.29840752
49ESR2_21235772_ChIP-Seq_MCF-7_Human1.29693158
50GATA1_19941826_ChIP-Seq_K562_Human1.28507518
51ZNF263_19887448_ChIP-Seq_K562_Human1.27778337
52IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.26925050
53TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.26487979
54LXR_22292898_ChIP-Seq_THP-1_Human1.26445353
55SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.23261413
56CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.22606035
57IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.22178285
58TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21846789
59ELF1_20517297_ChIP-Seq_JURKAT_Human1.21692139
60* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.19158048
61* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.18996488
62* HNF4A_19822575_ChIP-Seq_HepG2_Human1.18899635
63KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.18500891
64TRIM28_21343339_ChIP-Seq_HEK293_Human1.17631173
65* SA1_27219007_Chip-Seq_ERYTHROID_Human1.17250182
66RACK7_27058665_Chip-Seq_MCF-7_Human1.17143228
67P68_20966046_ChIP-Seq_HELA_Human1.16951434
68HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.15895334
69GATA4_25053715_ChIP-Seq_YYC3_Human1.13296862
70TP63_17297297_ChIP-ChIP_HaCaT_Human1.13259299
71GATA2_21666600_ChIP-Seq_HMVEC_Human1.12488629
72* TFEB_21752829_ChIP-Seq_HELA_Human1.12153822
73NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.11889336
74PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.09421925
75PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.08903689
76UBF1/2_26484160_Chip-Seq_HMECs_Human1.07812393
77* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.07772404
78* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.06859838
79Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.06612264
80ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.06355318
81TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.06220918
82* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.05455577
83PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.03787804
84CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.03218311
85RXRA_24833708_ChIP-Seq_LIVER_Mouse1.03126848
86GATA2_22383799_ChIP-Seq_G1ME_Mouse1.02120856
87TBX20_22080862_ChIP-Seq_HEART_Mouse1.01906389
88TBX20_22328084_ChIP-Seq_HEART_Mouse1.01906389
89SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.01782046
90ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01666518
91GATA2_19941826_ChIP-Seq_K562_Human1.01518677
92SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01422708
93TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.00843302
94* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.00130900
95SRY_22984422_ChIP-ChIP_TESTIS_Rat0.99731276
96STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.98824850
97TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.98619481
98GATA1_19941827_ChIP-Seq_MEL_Mouse0.97677189
99NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.96797888
100SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.96340070
101SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.96278125
102* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.96066710
103* BCOR_27268052_Chip-Seq_Bcells_Human0.96023807
104* ELK3_25401928_ChIP-Seq_HUVEC_Human0.95669038
105ESR1_21235772_ChIP-Seq_MCF-7_Human0.94148606
106RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.92184001
107ATF3_27146783_Chip-Seq_COLON_Human0.92110336
108FOXO3_23340844_ChIP-Seq_DLD1_Human0.91243159
109GATA6_25053715_ChIP-Seq_YYC3_Human0.89727583
110STAT3_1855785_ChIP-Seq_MESCs_Mouse0.89340829
111SCL_19346495_ChIP-Seq_HPC-7_Human0.88203725
112* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.87764002
113* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.87138123
114ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.85716108
115IRF8_21731497_ChIP-ChIP_J774_Mouse0.84721967
116GATA1_22383799_ChIP-Seq_G1ME_Mouse0.84399520
117RARA_24833708_ChIP-Seq_LIVER_Mouse0.80286923
118* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.79384901
119NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.79287126
120CDX2_20551321_ChIP-Seq_CACO-2_Human0.79101964
121FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.78710561
122TCF7_22412390_ChIP-Seq_EML_Mouse0.77446654
123GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.77326283
124* IRF8_27001747_Chip-Seq_BMDM_Mouse0.77199047
125NCOR1_26117541_ChIP-Seq_K562_Human0.76195138
126* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.76020913
127RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.75660504
128P63_26484246_Chip-Seq_KERATINOCYTES_Human0.75492206
129AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.75386758
130* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.75076105
131BCL6_27268052_Chip-Seq_Bcells_Human0.74790235
132SALL4_18804426_ChIP-ChIP_XEN_Mouse0.74304374
133FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.73571087
134SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.72055743
135TET1_21451524_ChIP-Seq_MESCs_Mouse0.71781427
136PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.71495621
137MAF_26560356_Chip-Seq_TH1_Human0.71210027
138* GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.71017025
139* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.70153162
140* KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.69777440
141MYB_21317192_ChIP-Seq_ERMYB_Mouse0.69086393
142* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.68822816
143ESR1_20079471_ChIP-ChIP_T-47D_Human0.68085759
144ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.67874326
145KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.67627584
146RARB_24833708_ChIP-Seq_LIVER_Mouse0.67359891
147SOX2_20726797_ChIP-Seq_SW620_Human0.67075547

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.77182405
2MP0005360_urolithiasis6.31055289
3MP0005085_abnormal_gallbladder_physiolo4.64791721
4MP0005365_abnormal_bile_salt4.55457860
5MP0009840_abnormal_foam_cell3.67498010
6MP0003806_abnormal_nucleotide_metabolis3.66923238
7MP0008875_abnormal_xenobiotic_pharmacok3.58777089
8MP0003252_abnormal_bile_duct3.10261174
9MP0003303_peritoneal_inflammation2.96612019
10MP0010329_abnormal_lipoprotein_level2.74870604
11MP0003195_calcinosis2.67017452
12MP0005332_abnormal_amino_acid2.66882872
13MP0005083_abnormal_biliary_tract2.35313452
14MP0001666_abnormal_nutrient_absorption2.33825235
15MP0003724_increased_susceptibility_to2.29256123
16MP0003191_abnormal_cellular_cholesterol2.22182196
17MP0008260_abnormal_autophagy2.17952546
18MP0001835_abnormal_antigen_presentation2.16151499
19MP0003172_abnormal_lysosome_physiology2.15127401
20MP0004510_myositis2.09111581
21MP0003705_abnormal_hypodermis_morpholog2.04767582
22MP0002148_abnormal_hypersensitivity_rea2.00769485
23MP0005025_abnormal_response_to1.99071673
24MP0009785_altered_susceptibility_to1.98138190
25MP0000685_abnormal_immune_system1.96038501
26MP0002118_abnormal_lipid_homeostasis1.88223224
27MP0000609_abnormal_liver_physiology1.87914140
28MP0004019_abnormal_vitamin_homeostasis1.84864828
29MP0005000_abnormal_immune_tolerance1.84297127
30MP0001533_abnormal_skeleton_physiology1.79585385
31MP0003656_abnormal_erythrocyte_physiolo1.79154126
32MP0005319_abnormal_enzyme/_coenzyme1.77176856
33MP0005387_immune_system_phenotype1.74080787
34MP0001790_abnormal_immune_system1.74080787
35MP0003186_abnormal_redox_activity1.65298239
36MP0002452_abnormal_antigen_presenting1.60761829
37MP0009643_abnormal_urine_homeostasis1.60525967
38MP0000858_altered_metastatic_potential1.59692935
39MP0005451_abnormal_body_composition1.57227864
40MP0003828_pulmonary_edema1.55732089
41MP0002723_abnormal_immune_serum1.54810981
42MP0002138_abnormal_hepatobiliary_system1.54433068
43MP0005670_abnormal_white_adipose1.53612274
44MP0005058_abnormal_lysosome_morphology1.51187214
45MP0005076_abnormal_cell_differentiation1.51158170
46MP0009278_abnormal_bone_marrow1.48524492
47MP0001764_abnormal_homeostasis1.47376407
48MP0005584_abnormal_enzyme/coenzyme_acti1.47204033
49MP0002420_abnormal_adaptive_immunity1.45383631
50MP0002998_abnormal_bone_remodeling1.44671300
51MP0001819_abnormal_immune_cell1.44519500
52MP0008438_abnormal_cutaneous_collagen1.44136259
53MP0000343_altered_response_to1.43778373
54MP0001800_abnormal_humoral_immune1.43743871
55MP0002405_respiratory_system_inflammati1.43036582
56MP0005671_abnormal_response_to1.32936552
57MP0003091_abnormal_cell_migration1.32582817
58MP0009333_abnormal_splenocyte_physiolog1.28780245
59MP0004233_abnormal_muscle_weight1.28088561
60MP0002837_dystrophic_cardiac_calcinosis1.24470421
61MP0003868_abnormal_feces_composition1.23015199
62MP0004130_abnormal_muscle_cell1.20458969
63MP0003763_abnormal_thymus_physiology1.18137324
64MP0000598_abnormal_liver_morphology1.17979348
65MP0004043_abnormal_pH_regulation1.16436957
66MP0001853_heart_inflammation1.14651411
67MP0001849_ear_inflammation1.14254341
68MP0000716_abnormal_immune_system1.10030273
69MP0002796_impaired_skin_barrier1.07045209
70MP0005666_abnormal_adipose_tissue1.05964812
71MP0000749_muscle_degeneration1.05730274
72MP0010234_abnormal_vibrissa_follicle1.03752984
73MP0002398_abnormal_bone_marrow1.02862676
74MP0001542_abnormal_bone_strength1.02348892
75MP0000750_abnormal_muscle_regeneration1.02290845
76MP0005390_skeleton_phenotype1.01717494
77MP0003329_amyloid_beta_deposits1.00470377
78MP0004808_abnormal_hematopoietic_stem0.99961426
79MP0005164_abnormal_response_to0.98985156
80MP0002269_muscular_atrophy0.98891609
81MP0006036_abnormal_mitochondrial_physio0.98405891
82MP0003448_altered_tumor_morphology0.98404263
83MP0005636_abnormal_mineral_homeostasis0.98396629
84MP0001545_abnormal_hematopoietic_system0.98225636
85MP0005397_hematopoietic_system_phenotyp0.98225636
86MP0008469_abnormal_protein_level0.97436874
87MP0002722_abnormal_immune_system0.95539142
88MP0005408_hypopigmentation0.95244168
89MP0002332_abnormal_exercise_endurance0.94993393
90MP0005310_abnormal_salivary_gland0.94427749
91MP0002429_abnormal_blood_cell0.93705146
92MP0005165_increased_susceptibility_to0.92659371
93MP0001756_abnormal_urination0.89544367
94MP0001216_abnormal_epidermal_layer0.88960820
95MP0005501_abnormal_skin_physiology0.87357049
96MP0000604_amyloidosis0.87230596
97MP0009764_decreased_sensitivity_to0.86121999
98MP0005647_abnormal_sex_gland0.86061306
99MP0004858_abnormal_nervous_system0.85816319
100MP0002078_abnormal_glucose_homeostasis0.85627329
101MP0001958_emphysema0.85452441
102MP0000689_abnormal_spleen_morphology0.85310861
103MP0003795_abnormal_bone_structure0.85229198
104MP0003436_decreased_susceptibility_to0.83954286
105MP0003011_delayed_dark_adaptation0.83163897
106MP0000678_abnormal_parathyroid_gland0.82331874
107MP0000733_abnormal_muscle_development0.81795090
108MP0009642_abnormal_blood_homeostasis0.81761953
109MP0001851_eye_inflammation0.81749771
110MP0002136_abnormal_kidney_physiology0.81123380
111MP0003300_gastrointestinal_ulcer0.80279776
112MP0009763_increased_sensitivity_to0.80261693
113MP0003183_abnormal_peptide_metabolism0.79783937
114MP0000703_abnormal_thymus_morphology0.78189152
115MP0000465_gastrointestinal_hemorrhage0.78036591
116MP0002971_abnormal_brown_adipose0.77667459
117MP0005330_cardiomyopathy0.77416755
118MP0003075_altered_response_to0.76722873
119MP0000747_muscle_weakness0.76573075
120MP0005220_abnormal_exocrine_pancreas0.76045785
121MP0003690_abnormal_glial_cell0.75698480
122MP0005334_abnormal_fat_pad0.75561272
123MP0010368_abnormal_lymphatic_system0.75536495
124MP0006082_CNS_inflammation0.74738535
125MP0005375_adipose_tissue_phenotype0.73956314
126MP0005464_abnormal_platelet_physiology0.73893279
127MP0002166_altered_tumor_susceptibility0.73563388
128MP0002396_abnormal_hematopoietic_system0.73314022
129MP0004782_abnormal_surfactant_physiolog0.72278304
130MP0002132_abnormal_respiratory_system0.70408777
131MP0002060_abnormal_skin_morphology0.69797286
132MP0001873_stomach_inflammation0.69339176
133MP0005376_homeostasis/metabolism_phenot0.69286378
134MP0003646_muscle_fatigue0.68699989
135MP0003453_abnormal_keratinocyte_physiol0.68660827
136MP0002877_abnormal_melanocyte_morpholog0.68477557
137MP0004087_abnormal_muscle_fiber0.68256782
138MP0003566_abnormal_cell_adhesion0.67957566
139MP0004185_abnormal_adipocyte_glucose0.67288998
140MP0005023_abnormal_wound_healing0.61988359
141MP0001765_abnormal_ion_homeostasis0.59702706
142MP0009115_abnormal_fat_cell0.59549040
143MP0004036_abnormal_muscle_relaxation0.58068184
144MP0002254_reproductive_system_inflammat0.56322328
145MP0005266_abnormal_metabolism0.56291282
146MP0005084_abnormal_gallbladder_morpholo0.54740110
147MP0006054_spinal_hemorrhage0.54344143
148MP0003279_aneurysm0.53903929
149MP0002928_abnormal_bile_duct0.53641514
150MP0001243_abnormal_dermal_layer0.53275258
151MP0009053_abnormal_anal_canal0.53164398
152MP0009765_abnormal_xenobiotic_induced0.52405659
153MP0010630_abnormal_cardiac_muscle0.52238267
154MP0004947_skin_inflammation0.51725956
155MP0009384_cardiac_valve_regurgitation0.50883516
156MP0001845_abnormal_inflammatory_respons0.50875986
157MP0005448_abnormal_energy_balance0.48187529
158MP0002168_other_aberrant_phenotype0.47649298
159MP0005166_decreased_susceptibility_to0.46838282
160MP0005535_abnormal_body_temperature0.44681619
161MP0005385_cardiovascular_system_phenoty0.44573201
162MP0001544_abnormal_cardiovascular_syste0.44573201
163MP0000249_abnormal_blood_vessel0.44305231
164MP0010155_abnormal_intestine_physiology0.43654462
165MP0002135_abnormal_kidney_morphology0.43318931
166MP0002876_abnormal_thyroid_physiology0.42950118
167MP0002419_abnormal_innate_immunity0.42419563

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)5.67978794
2Abnormality of aromatic amino acid family metabolism (HP:0004338)5.63653122
3Xanthomatosis (HP:0000991)5.23616340
4Deep venous thrombosis (HP:0002625)5.18410452
5Abnormality of monocarboxylic acid metabolism (HP:0010996)5.03410607
6Abnormality of glycolipid metabolism (HP:0010969)4.74756057
7Abnormality of liposaccharide metabolism (HP:0010968)4.74756057
8Abnormality of glycosphingolipid metabolism (HP:0004343)4.74756057
9Hypobetalipoproteinemia (HP:0003563)4.28759677
10Prolonged partial thromboplastin time (HP:0003645)4.18838170
11Hyperglycinuria (HP:0003108)4.15694607
12Abnormality of glutamine family amino acid metabolism (HP:0010902)3.92940711
13Eczematoid dermatitis (HP:0000976)3.90324312
14Hyperlipoproteinemia (HP:0010980)3.88776289
15Hyperammonemia (HP:0001987)3.86959177
16Ketosis (HP:0001946)3.82794048
17Hypoglycemic coma (HP:0001325)3.82719174
18Abnormality of serine family amino acid metabolism (HP:0010894)3.81279017
19Abnormality of glycine metabolism (HP:0010895)3.81279017
20Recurrent abscess formation (HP:0002722)3.73932725
21Dysostosis multiplex (HP:0000943)3.67774788
22Recurrent bacterial skin infections (HP:0005406)3.66051039
23Complement deficiency (HP:0004431)3.65827349
24Abnormality of macrophages (HP:0004311)3.65240909
25Hyperglycinemia (HP:0002154)3.63356535
26Joint hemorrhage (HP:0005261)3.57538017
27Abnormality of fatty-acid metabolism (HP:0004359)3.53320206
28Hypolipoproteinemia (HP:0010981)3.50113626
29Fat malabsorption (HP:0002630)3.48367799
30Abnormality of sulfur amino acid metabolism (HP:0004339)3.45305646
31Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.34523816
32Hypoalphalipoproteinemia (HP:0003233)3.28963965
33Abnormality of the common coagulation pathway (HP:0010990)3.24133258
34Abnormality of aspartate family amino acid metabolism (HP:0010899)3.22322447
35Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.22263720
36Ketoacidosis (HP:0001993)3.22177911
37Epidermoid cyst (HP:0200040)3.14336133
38Vertebral compression fractures (HP:0002953)3.13818034
39Loss of speech (HP:0002371)3.11590949
40Myocardial infarction (HP:0001658)3.10923468
41Abnormality of the intrinsic pathway (HP:0010989)3.09618931
42Gout (HP:0001997)3.07680069
43Increased cerebral lipofuscin (HP:0011813)3.07358337
44Abnormality of purine metabolism (HP:0004352)2.97152745
45Hyperbilirubinemia (HP:0002904)2.96847689
46Abnormality of mucopolysaccharide metabolism (HP:0011020)2.92314672
47Abnormality of polysaccharide metabolism (HP:0011012)2.92314672
48Abnormality of glycosaminoglycan metabolism (HP:0004371)2.92314672
49Abnormality of methionine metabolism (HP:0010901)2.90724828
50Mucopolysacchariduria (HP:0008155)2.87612590
51Urinary glycosaminoglycan excretion (HP:0003541)2.87612590
52Abnormality of complement system (HP:0005339)2.83917821
53Abnormality of nucleobase metabolism (HP:0010932)2.78588266
54Abnormal gallbladder morphology (HP:0012437)2.76719010
55Hypercholesterolemia (HP:0003124)2.76353151
56Increased serum ferritin (HP:0003281)2.74513934
57Vacuolated lymphocytes (HP:0001922)2.74344789
58Vascular calcification (HP:0004934)2.70978623
59Late onset (HP:0003584)2.70463464
60Steatorrhea (HP:0002570)2.67396031
61Cholelithiasis (HP:0001081)2.66738290
62Myositis (HP:0100614)2.64510411
63Dicarboxylic aciduria (HP:0003215)2.59043494
64Abnormality of dicarboxylic acid metabolism (HP:0010995)2.59043494
65Conjugated hyperbilirubinemia (HP:0002908)2.58737989
66Interstitial pulmonary disease (HP:0006530)2.56466548
67Orchitis (HP:0100796)2.55193534
68Generalized aminoaciduria (HP:0002909)2.55009589
69Increased neuronal autofluorescent lipopigment (HP:0002074)2.54713416
70Cardiovascular calcification (HP:0011915)2.51505477
71Centrally nucleated skeletal muscle fibers (HP:0003687)2.47444476
72Hepatocellular carcinoma (HP:0001402)2.47172129
73Metabolic acidosis (HP:0001942)2.46684576
74Hypoglycemic seizures (HP:0002173)2.45975125
75Mitral stenosis (HP:0001718)2.42994093
76Gingivitis (HP:0000230)2.42082086
77Abnormality of pyrimidine metabolism (HP:0004353)2.41459307
78Distal lower limb muscle weakness (HP:0009053)2.40891222
79Increased IgE level (HP:0003212)2.40028972
80Myoglobinuria (HP:0002913)2.39220153
81Mediastinal lymphadenopathy (HP:0100721)2.36883286
82Hyperinsulinemic hypoglycemia (HP:0000825)2.36880100
83Abnormality of proline metabolism (HP:0010907)2.35601597
84Hydroxyprolinuria (HP:0003080)2.35601597
85Cellulitis (HP:0100658)2.35408492
86Systemic lupus erythematosus (HP:0002725)2.32972610
87Amyloidosis (HP:0011034)2.31296846
88Abnormality of serum amino acid levels (HP:0003112)2.30184741
89Recurrent skin infections (HP:0001581)2.30131007
90Slow saccadic eye movements (HP:0000514)2.28719254
91Increased connective tissue (HP:0009025)2.28119910
92Exercise-induced muscle cramps (HP:0003710)2.27886291
93Skin nodule (HP:0200036)2.27545018
94Sensorimotor neuropathy (HP:0007141)2.25006592
95Abnormality of the gallbladder (HP:0005264)2.19563369
96Ragged-red muscle fibers (HP:0003200)2.18399042
97Axonal loss (HP:0003447)2.18365462
98Elevated erythrocyte sedimentation rate (HP:0003565)2.16400021
99Increased purine levels (HP:0004368)2.15617435
100Hyperuricemia (HP:0002149)2.15617435
101Acanthocytosis (HP:0001927)2.13493784
102Malnutrition (HP:0004395)2.13272776
103Hepatosplenomegaly (HP:0001433)2.11231795
104Petechiae (HP:0000967)2.08166408
105Cervical subluxation (HP:0003308)2.07851422
106Lethargy (HP:0001254)2.07214059
107Irritability (HP:0000737)2.06483722
108Proximal tubulopathy (HP:0000114)2.06442545
109Recurrent fungal infections (HP:0002841)2.05537283
110Obstructive lung disease (HP:0006536)2.03592924
111Chronic obstructive pulmonary disease (HP:0006510)2.03592924
112Reticulocytosis (HP:0001923)2.02993312
113Abnormal enzyme/coenzyme activity (HP:0012379)2.02958011
114Abnormality of transition element cation homeostasis (HP:0011030)2.01547715
115Colitis (HP:0002583)2.01541012
116Distal lower limb amyotrophy (HP:0008944)2.01431653
117Osteolytic defects of the phalanges of the hand (HP:0009771)2.00303622
118Osteolytic defects of the hand bones (HP:0009699)2.00303622
119Opisthotonus (HP:0002179)1.98684342
120Esophageal varix (HP:0002040)1.97951174
121Recurrent gram-negative bacterial infections (HP:0005420)1.97324205
122Rough bone trabeculation (HP:0100670)1.96170365
123Delayed CNS myelination (HP:0002188)1.95213316
124Pancreatitis (HP:0001733)1.94401383
125Thin bony cortex (HP:0002753)1.94335276
126Abnormal gallbladder physiology (HP:0012438)1.93069709
127Cholecystitis (HP:0001082)1.93069709
128Gingival bleeding (HP:0000225)1.92934404
129Progressive muscle weakness (HP:0003323)1.92647369
130Prolonged neonatal jaundice (HP:0006579)1.92618484
131Poikilocytosis (HP:0004447)1.92391935
132Protrusio acetabuli (HP:0003179)1.91176366
133Nuclear cataract (HP:0100018)1.88902293
134Short nail (HP:0001799)1.88310105
135Premature rupture of membranes (HP:0001788)1.87940337
136Right ventricular cardiomyopathy (HP:0011663)1.87815739
137Lower limb hyperreflexia (HP:0002395)1.86641740
138Urticaria (HP:0001025)1.86082069
139Spondylolisthesis (HP:0003302)1.85921928
140Hemorrhage of the eye (HP:0011885)1.84484108
141Polycythemia (HP:0001901)1.84186914
142Abnormality of the distal phalanges of the toes (HP:0010182)1.84059684
143Abnormality of iron homeostasis (HP:0011031)1.83977801
144Abnormality of alkaline phosphatase activity (HP:0004379)1.83865106
145Joint stiffness (HP:0001387)1.83094705
146Spontaneous abortion (HP:0005268)1.81750571
147Vomiting (HP:0002013)1.81338437
148Symptomatic seizures (HP:0011145)1.81070449
149Generalized amyotrophy (HP:0003700)1.80994713
150Elevated alkaline phosphatase (HP:0003155)1.80928527
151Reduced subcutaneous adipose tissue (HP:0003758)1.80718969
152Hyperglycemia (HP:0003074)1.80476184
153Achilles tendon contracture (HP:0001771)1.80116042
154Alkalosis (HP:0001948)1.79830107
155Ileus (HP:0002595)1.79770033
156Glycosuria (HP:0003076)1.79685094
157Abnormality of urine glucose concentration (HP:0011016)1.79685094
158Asymmetric septal hypertrophy (HP:0001670)1.79471298
159Segmental peripheral demyelination/remyelination (HP:0003481)1.78894520
160Hypertensive crisis (HP:0100735)1.77766127
161Purpura (HP:0000979)1.76773061
162Neuronal loss in central nervous system (HP:0002529)1.75298786
163Gastrointestinal inflammation (HP:0004386)1.74765500
164Pathologic fracture (HP:0002756)1.74466183
165Optic neuritis (HP:0100653)1.74101821
166Retrobulbar optic neuritis (HP:0100654)1.74101821
167Progressive neurologic deterioration (HP:0002344)1.73182708
168Broad face (HP:0000283)1.72614368
169Polygenic inheritance (HP:0010982)1.70659637
170Autoimmune thrombocytopenia (HP:0001973)1.69045993
171Bulbar palsy (HP:0001283)1.68759988
172Stomatitis (HP:0010280)1.68243564
173Recurrent cutaneous fungal infections (HP:0011370)1.67591387
174Chronic mucocutaneous candidiasis (HP:0002728)1.67591387
175Thick nail (HP:0001805)1.67572176
176Inflammation of the large intestine (HP:0002037)1.66140576
177Thoracic kyphosis (HP:0002942)1.63890079
178Bone pain (HP:0002653)1.63837400
179J-shaped sella turcica (HP:0002680)1.61944197
180Hypertriglyceridemia (HP:0002155)1.61487681
181Abnormality of the Achilles tendon (HP:0005109)1.61484507
182Cheilitis (HP:0100825)1.61277435
183Recurrent viral infections (HP:0004429)1.61091613
184Abnormal trabecular bone morphology (HP:0100671)1.60755314
185Upper motor neuron abnormality (HP:0002127)1.60402446
186Pustule (HP:0200039)1.59672013
187Difficulty climbing stairs (HP:0003551)1.59607946
188Cerebral inclusion bodies (HP:0100314)1.59219458
189Meningitis (HP:0001287)1.58699316

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK4.63980336
2ERN14.22538094
3TRIB33.42992458
4SIK13.35766018
5NME22.72008298
6PKN22.42653284
7TESK22.26159161
8SMG12.13213854
9RIPK42.08360087
10EPHB12.04575364
11PRPF4B2.00463335
12BLK1.92285211
13TTN1.91937771
14FGFR41.85416534
15TAOK21.79212892
16AKT31.74755435
17TBK11.68258995
18TESK11.65716500
19PTK61.65005375
20TAOK31.57867604
21WNK41.57435098
22TRPM71.55571956
23MAP3K141.55387865
24IRAK31.45054305
25MAP3K11.43550686
26NEK91.38791701
27TYK21.38130776
28MAP3K101.36322548
29LATS11.35600415
30BMX1.34886315
31TAOK11.34573405
32TLK11.34031761
33PINK11.32257468
34ICK1.30318190
35MAPK111.29923217
36FLT31.29315680
37IRAK41.27931457
38ARAF1.26890558
39PIK3CG1.24994488
40MAP3K31.24557597
41OBSCN1.23343892
42PAK41.20920977
43INSRR1.17349842
44FRK1.16710247
45STK391.14446504
46PIM11.11885086
47IKBKE1.09120681
48STK38L1.07643705
49EEF2K1.06894612
50ERBB41.06204914
51MAPK151.04065609
52MAP3K131.01174054
53MET1.00275627
54MAP2K30.98532581
55CDC42BPA0.98193252
56EPHA20.98018695
57STK40.96420427
58JAK10.92201031
59GSK3A0.88596779
60TGFBR20.88266900
61SGK30.87548210
62DYRK1B0.86541609
63MST1R0.85530861
64JAK20.85185903
65PDK40.84171628
66PDK30.84171628
67PDK20.84073171
68MOS0.81774770
69CHUK0.80564978
70PRKAA20.79981640
71IKBKB0.79469701
72PDPK10.78440137
73HIPK20.76077135
74PRKAA10.75864256
75MARK20.74363770
76JAK30.74151988
77MAP3K70.73235794
78ABL20.72608617
79SGK4940.70815949
80SGK2230.70815949
81RPS6KA20.69637162
82PIM20.69020230
83CSK0.67543219
84HCK0.64456447
85PIK3CA0.63581756
86IRAK20.63504903
87GRK70.63442658
88MAPKAPK30.63354034
89RPS6KA60.62389829
90PBK0.61925958
91PRKCH0.61180887
92MAP3K120.60988378
93MAP3K80.60813797
94MAP3K60.59996639
95STK100.58825508
96STK380.58799716
97TNK20.58285943
98SGK20.56986343
99DDR20.56956195
100FGR0.56027078
101PKN10.55746017
102MTOR0.54467558
103MYLK0.54341997
104PDGFRA0.54121211
105CSF1R0.54065389
106FES0.53999734
107STK240.53634760
108CLK10.53380690
109MAPK70.53175728
110BTK0.52926047
111GRK60.52638437
112RPS6KC10.52637938
113RPS6KL10.52637938
114MAPKAPK20.51979731
115MATK0.51479859
116CDK120.50699882
117PTK20.50306471
118KSR20.49936482
119PRKD20.49843111
120MAP2K20.49741113
121LMTK20.49678817
122OXSR10.49180218
123SIK30.48686561
124LRRK20.48353022
125FGFR30.48026506
126PRKD10.47219125
127MUSK0.46009415
128PDK10.45498413
129ZAP700.45301688
130MAP4K10.45158459
131DAPK30.44575647
132EPHA30.43915705
133STK30.43449235
134MAP3K110.42564074
135MAP3K20.39888199
136KIT0.39528540
137MARK30.38426435
138IRAK10.37776827
139SYK0.37412632
140RIPK10.36165485
141PRKG20.35685003
142PRKACG0.35063299
143CDK60.34598533
144MAPK120.33947957

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.83321042
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.08516936
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.06673250
4Nitrogen metabolism_Homo sapiens_hsa009102.85142450
5Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.80370870
6Fatty acid degradation_Homo sapiens_hsa000712.69154096
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.67227294
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.64837725
9Osteoclast differentiation_Homo sapiens_hsa043802.59494291
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.54461846
11Arginine biosynthesis_Homo sapiens_hsa002202.53658216
12Tryptophan metabolism_Homo sapiens_hsa003802.43708253
13Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.39696998
14Pentose and glucuronate interconversions_Homo sapiens_hsa000402.21117592
15Toll-like receptor signaling pathway_Homo sapiens_hsa046202.19851412
16Propanoate metabolism_Homo sapiens_hsa006402.13409157
17Fatty acid metabolism_Homo sapiens_hsa012122.06691820
18Leishmaniasis_Homo sapiens_hsa051402.05433726
19Peroxisome_Homo sapiens_hsa041462.05329058
20Complement and coagulation cascades_Homo sapiens_hsa046102.02378450
21Butanoate metabolism_Homo sapiens_hsa006501.97993361
222-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.95580691
23PPAR signaling pathway_Homo sapiens_hsa033201.90581480
24NF-kappa B signaling pathway_Homo sapiens_hsa040641.81492858
25Selenocompound metabolism_Homo sapiens_hsa004501.80875110
26Tuberculosis_Homo sapiens_hsa051521.80738580
27Sulfur metabolism_Homo sapiens_hsa009201.74256602
28TNF signaling pathway_Homo sapiens_hsa046681.71480570
29Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.71283425
30B cell receptor signaling pathway_Homo sapiens_hsa046621.66591886
31Histidine metabolism_Homo sapiens_hsa003401.62842947
32Fatty acid elongation_Homo sapiens_hsa000621.58198112
33Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.57037391
34Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.55939660
35Malaria_Homo sapiens_hsa051441.54873905
36Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.53382167
37Toxoplasmosis_Homo sapiens_hsa051451.52590187
38Chemical carcinogenesis_Homo sapiens_hsa052041.52437324
39beta-Alanine metabolism_Homo sapiens_hsa004101.52173046
40Starch and sucrose metabolism_Homo sapiens_hsa005001.50933606
41Influenza A_Homo sapiens_hsa051641.46020799
42Pertussis_Homo sapiens_hsa051331.45948983
43Shigellosis_Homo sapiens_hsa051311.45857487
44Pyruvate metabolism_Homo sapiens_hsa006201.42957155
45Carbon metabolism_Homo sapiens_hsa012001.41851772
46Steroid hormone biosynthesis_Homo sapiens_hsa001401.40500582
47Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.38458437
48Fat digestion and absorption_Homo sapiens_hsa049751.38364131
49Maturity onset diabetes of the young_Homo sapiens_hsa049501.38089716
50Staphylococcus aureus infection_Homo sapiens_hsa051501.37904488
51Bile secretion_Homo sapiens_hsa049761.37607206
52Systemic lupus erythematosus_Homo sapiens_hsa053221.37027917
53Chronic myeloid leukemia_Homo sapiens_hsa052201.34901104
54Steroid biosynthesis_Homo sapiens_hsa001001.34233414
55Drug metabolism - other enzymes_Homo sapiens_hsa009831.33334258
56Apoptosis_Homo sapiens_hsa042101.32924086
57Biosynthesis of amino acids_Homo sapiens_hsa012301.32786853
58Retinol metabolism_Homo sapiens_hsa008301.32082214
59NOD-like receptor signaling pathway_Homo sapiens_hsa046211.31028991
60Folate biosynthesis_Homo sapiens_hsa007901.29271798
61Hepatitis B_Homo sapiens_hsa051611.25381456
62Rheumatoid arthritis_Homo sapiens_hsa053231.24319675
63Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.23386107
64Phagosome_Homo sapiens_hsa041451.23242472
65Caffeine metabolism_Homo sapiens_hsa002321.20957186
66Arginine and proline metabolism_Homo sapiens_hsa003301.20709563
67Salmonella infection_Homo sapiens_hsa051321.19720139
68Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.19395402
69Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.19143731
70ABC transporters_Homo sapiens_hsa020101.17722768
71Allograft rejection_Homo sapiens_hsa053301.17404149
72Phenylalanine metabolism_Homo sapiens_hsa003601.16621310
73Cyanoamino acid metabolism_Homo sapiens_hsa004601.16291830
74Viral carcinogenesis_Homo sapiens_hsa052031.14588870
75Herpes simplex infection_Homo sapiens_hsa051681.13194962
76Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.13088204
77Measles_Homo sapiens_hsa051621.13048503
78Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.11201988
79Pancreatic cancer_Homo sapiens_hsa052121.09502659
80Cysteine and methionine metabolism_Homo sapiens_hsa002701.08599813
81Non-small cell lung cancer_Homo sapiens_hsa052231.07935935
82Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.06864451
83Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.04435735
84Leukocyte transendothelial migration_Homo sapiens_hsa046701.04118107
85Vitamin digestion and absorption_Homo sapiens_hsa049771.02355211
86Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.01508232
87Viral myocarditis_Homo sapiens_hsa054161.00849998
88VEGF signaling pathway_Homo sapiens_hsa043700.99470426
89Autoimmune thyroid disease_Homo sapiens_hsa053200.98269907
90Vitamin B6 metabolism_Homo sapiens_hsa007500.97846261
91Vibrio cholerae infection_Homo sapiens_hsa051100.97614595
92Graft-versus-host disease_Homo sapiens_hsa053320.97343581
93Lysine degradation_Homo sapiens_hsa003100.96316212
94Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.95998943
95Intestinal immune network for IgA production_Homo sapiens_hsa046720.95967816
96Chemokine signaling pathway_Homo sapiens_hsa040620.93721652
97Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.93682136
98Antigen processing and presentation_Homo sapiens_hsa046120.92740754
99Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.92095741
100AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.91326161
101Tyrosine metabolism_Homo sapiens_hsa003500.91196616
102Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.89501310
103Pentose phosphate pathway_Homo sapiens_hsa000300.87827701
104Jak-STAT signaling pathway_Homo sapiens_hsa046300.87777967
105Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.87656440
106T cell receptor signaling pathway_Homo sapiens_hsa046600.86676277
107Endocytosis_Homo sapiens_hsa041440.86625838
108Glutathione metabolism_Homo sapiens_hsa004800.85974388
109Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.85416410
110Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.84504838
111Sulfur relay system_Homo sapiens_hsa041220.83258445
112Neurotrophin signaling pathway_Homo sapiens_hsa047220.81215197
113Hematopoietic cell lineage_Homo sapiens_hsa046400.78368025
114Fatty acid biosynthesis_Homo sapiens_hsa000610.76616386
115Glycerolipid metabolism_Homo sapiens_hsa005610.74958917
116mTOR signaling pathway_Homo sapiens_hsa041500.74671388
117Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.74605650
118Notch signaling pathway_Homo sapiens_hsa043300.73201539
119HTLV-I infection_Homo sapiens_hsa051660.71824863
120Epstein-Barr virus infection_Homo sapiens_hsa051690.68910649
121Small cell lung cancer_Homo sapiens_hsa052220.66978569
122African trypanosomiasis_Homo sapiens_hsa051430.64518360
123Galactose metabolism_Homo sapiens_hsa000520.63472150
124Asthma_Homo sapiens_hsa053100.61993912
125Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.61763629
126Sphingolipid metabolism_Homo sapiens_hsa006000.60463367
127Prolactin signaling pathway_Homo sapiens_hsa049170.60140072
128Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.60126408
129Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.57798336
130One carbon pool by folate_Homo sapiens_hsa006700.56420127
131Transcriptional misregulation in cancer_Homo sapiens_hsa052020.56350371
132Sphingolipid signaling pathway_Homo sapiens_hsa040710.56026317
133Endometrial cancer_Homo sapiens_hsa052130.55262568
134Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.55166433
135Type I diabetes mellitus_Homo sapiens_hsa049400.52410516
136Renal cell carcinoma_Homo sapiens_hsa052110.52384785
137Longevity regulating pathway - mammal_Homo sapiens_hsa042110.51973482
138Proteoglycans in cancer_Homo sapiens_hsa052050.50804975
139Adipocytokine signaling pathway_Homo sapiens_hsa049200.50160027
140Thyroid cancer_Homo sapiens_hsa052160.48543912
141HIF-1 signaling pathway_Homo sapiens_hsa040660.48537544
142Fructose and mannose metabolism_Homo sapiens_hsa000510.47629072
143Insulin resistance_Homo sapiens_hsa049310.47578754
144Prostate cancer_Homo sapiens_hsa052150.45965326
145Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.45798168
146Metabolic pathways_Homo sapiens_hsa011000.44167063
147* Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.44038879
148Focal adhesion_Homo sapiens_hsa045100.43510731
149Prion diseases_Homo sapiens_hsa050200.39639112
150Lysosome_Homo sapiens_hsa041420.31421170
151Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.24378057
152alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.19242667
153Renin-angiotensin system_Homo sapiens_hsa046140.19071906
154Glycosaminoglycan degradation_Homo sapiens_hsa005310.18948507
155Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.17930091
156AMPK signaling pathway_Homo sapiens_hsa041520.17393707
157Other glycan degradation_Homo sapiens_hsa005110.15873057
158Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.11269477
159Glucagon signaling pathway_Homo sapiens_hsa049220.10955287
160Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.10919369
161Glycerophospholipid metabolism_Homo sapiens_hsa005640.09145894
162Linoleic acid metabolism_Homo sapiens_hsa005910.06215032
163Protein digestion and absorption_Homo sapiens_hsa049740.06123043
164Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.06053010
165Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.04591170
166Bladder cancer_Homo sapiens_hsa052190.04439729
167Amoebiasis_Homo sapiens_hsa051460.04375679
168Hepatitis C_Homo sapiens_hsa051600.03567755
169Insulin signaling pathway_Homo sapiens_hsa049100.02869393
170Legionellosis_Homo sapiens_hsa051340.02527119
171Carbohydrate digestion and absorption_Homo sapiens_hsa049730.02215194
172Central carbon metabolism in cancer_Homo sapiens_hsa052300.00434528
173Arachidonic acid metabolism_Homo sapiens_hsa005900.00246386
174RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622-0.0263583
175Acute myeloid leukemia_Homo sapiens_hsa05221-0.0186283

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