DNAJB13

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the heat shock protein 40 co-chaperone family which is produced in large amounts in the testis and is located on the radial spokes of the axoneme in human sperm flagella and other flagellar structures. The encoded protein associates with the sperm annulus, as part of the septin complex, through direct interaction with septin 4, during sperm terminal differentiation. Naturally occurring mutations in this gene are associated with primary ciliary dyskinesia and male infertility. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epithelial cilium movement (GO:0003351)9.78309696
2sperm-egg recognition (GO:0035036)9.73945879
3acrosome assembly (GO:0001675)9.69961250
4multicellular organism reproduction (GO:0032504)9.27200996
5cilium movement (GO:0003341)9.12120909
6cell-cell recognition (GO:0009988)8.89336783
7binding of sperm to zona pellucida (GO:0007339)8.87606906
8spermatid development (GO:0007286)8.28577007
9plasma membrane fusion (GO:0045026)8.28190513
10regulation of cilium movement (GO:0003352)8.23635751
11epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.97254667
12reproduction (GO:0000003)7.80238173
13single fertilization (GO:0007338)6.54107454
14piRNA metabolic process (GO:0034587)6.44181801
15negative regulation of inclusion body assembly (GO:0090084)6.11224475
16male meiosis (GO:0007140)6.06593109
17synaptonemal complex organization (GO:0070193)5.95343394
18sperm capacitation (GO:0048240)5.90079834
19spermatogenesis (GO:0007283)5.83349401
20male gamete generation (GO:0048232)5.81053472
21microtubule depolymerization (GO:0007019)5.69926039
22synaptonemal complex assembly (GO:0007130)5.68221167
23fertilization (GO:0009566)5.43860271
24gamete generation (GO:0007276)5.35315175
25regulation of inclusion body assembly (GO:0090083)5.12266849
26ventricular system development (GO:0021591)5.12075615
27organic cation transport (GO:0015695)4.96078704
28germ cell development (GO:0007281)4.65500822
29cellular process involved in reproduction in multicellular organism (GO:0022412)4.63468874
30vitamin transmembrane transport (GO:0035461)4.61593856
31axoneme assembly (GO:0035082)4.60983125
32microtubule bundle formation (GO:0001578)4.58480264
33diterpenoid biosynthetic process (GO:0016102)4.49783774
34chromosome condensation (GO:0030261)4.46392819
35male meiosis I (GO:0007141)4.41458159
36DNA packaging (GO:0006323)4.39550695
37regulation of microtubule-based movement (GO:0060632)4.36201023
38microtubule severing (GO:0051013)4.30461461
39sequestering of actin monomers (GO:0042989)4.27886883
40multicellular organismal reproductive process (GO:0048609)4.20346221
41DNA methylation involved in gamete generation (GO:0043046)4.16838707
42calcium ion-dependent exocytosis (GO:0017156)4.14003398
43primary alcohol catabolic process (GO:0034310)4.12019191
44chromosome organization involved in meiosis (GO:0070192)4.06539175
45cell recognition (GO:0008037)4.02707405
46terpenoid biosynthetic process (GO:0016114)3.81988974
47meiotic nuclear division (GO:0007126)3.79773770
48seminiferous tubule development (GO:0072520)3.75496005
49glycerol ether metabolic process (GO:0006662)3.75390451
50spermatid nucleus differentiation (GO:0007289)3.71294236
51one-carbon compound transport (GO:0019755)3.71055372
52negative regulation of T cell differentiation in thymus (GO:0033085)3.69544601
53ethanol metabolic process (GO:0006067)3.68561694
54pyrimidine-containing compound transmembrane transport (GO:0072531)3.67743744
55cell projection assembly (GO:0030031)3.64287557
56protein localization to cilium (GO:0061512)3.63434561
57response to xenobiotic stimulus (GO:0009410)3.62076579
58meiosis I (GO:0007127)3.58497852
59left/right pattern formation (GO:0060972)3.58134137
60meiotic cell cycle (GO:0051321)3.56117710
61regulation of germinal center formation (GO:0002634)3.55181645
62negative regulation of immunoglobulin mediated immune response (GO:0002890)3.52440383
63negative regulation of B cell mediated immunity (GO:0002713)3.52440383
64intraciliary transport (GO:0042073)3.45616339
65ether metabolic process (GO:0018904)3.45387383
66protein polyglutamylation (GO:0018095)3.39718144
67centriole assembly (GO:0098534)3.38453950
68photoreceptor cell maintenance (GO:0045494)3.38137435
69L-fucose catabolic process (GO:0042355)3.36438246
70fucose catabolic process (GO:0019317)3.36438246
71L-fucose metabolic process (GO:0042354)3.36438246
72cilium organization (GO:0044782)3.32158795
73nucleoside diphosphate phosphorylation (GO:0006165)3.31763867
74exogenous drug catabolic process (GO:0042738)3.31141766
75glutathione derivative biosynthetic process (GO:1901687)3.30963710
76glutathione derivative metabolic process (GO:1901685)3.30963710
77multicellular organismal development (GO:0007275)3.29389592
78monoubiquitinated protein deubiquitination (GO:0035520)3.24195311
79nucleotide transmembrane transport (GO:1901679)3.22657467
80cornea development in camera-type eye (GO:0061303)3.20540556
81cilium assembly (GO:0042384)3.19833432
82retinoic acid metabolic process (GO:0042573)3.19721637
83retinal cone cell development (GO:0046549)3.18973952
84regulation of chromatin binding (GO:0035561)3.18869908
85retinal rod cell development (GO:0046548)3.15624893
86cilium morphogenesis (GO:0060271)3.13786146
87protein K11-linked deubiquitination (GO:0035871)3.11242005
88single strand break repair (GO:0000012)3.10511887
89GTP biosynthetic process (GO:0006183)3.09410433
90natural killer cell mediated cytotoxicity (GO:0042267)3.08395829
91natural killer cell mediated immunity (GO:0002228)3.08395829
92phosphatidylethanolamine metabolic process (GO:0046337)3.06257005
93neural tube formation (GO:0001841)3.05632103
94mitotic sister chromatid cohesion (GO:0007064)3.01918154
95phosphatidylethanolamine biosynthetic process (GO:0006646)3.01545762
96regulation of spindle checkpoint (GO:0090231)3.00866141
97negative regulation of humoral immune response (GO:0002921)2.99593659
98regulation of interleukin-5 production (GO:0032674)2.96539796
99nonmotile primary cilium assembly (GO:0035058)2.90798488
100nucleus organization (GO:0006997)2.88945223
101chaperone-mediated protein complex assembly (GO:0051131)2.88599844
102cellular component assembly involved in morphogenesis (GO:0010927)2.87735416
103rRNA catabolic process (GO:0016075)2.87707423
104left/right axis specification (GO:0070986)2.87595477
105determination of left/right symmetry (GO:0007368)2.87454497
106oligosaccharide biosynthetic process (GO:0009312)2.87406585
107drug catabolic process (GO:0042737)2.83856379
108microtubule-based movement (GO:0007018)2.82584685
109detection of light stimulus involved in visual perception (GO:0050908)2.81970900
110detection of light stimulus involved in sensory perception (GO:0050962)2.81970900
111DNA deamination (GO:0045006)2.80199999
112RNA destabilization (GO:0050779)2.80146867
113genitalia morphogenesis (GO:0035112)2.79476085
114smoothened signaling pathway (GO:0007224)2.78008462
115UTP biosynthetic process (GO:0006228)2.76698731
116determination of bilateral symmetry (GO:0009855)2.73742783
117positive regulation of tolerance induction (GO:0002645)2.73415089
118lung epithelium development (GO:0060428)2.73053999
119ethanol oxidation (GO:0006069)2.71669693
120regulation of podosome assembly (GO:0071801)2.71407900
121lactate metabolic process (GO:0006089)2.70342531
122interferon-gamma secretion (GO:0072643)2.69982613
123coenzyme catabolic process (GO:0009109)2.68852037
124regulation of autophagic vacuole assembly (GO:2000785)2.65938105
125sexual reproduction (GO:0019953)2.65868292
126meiotic cell cycle process (GO:1903046)2.65003808
127specification of symmetry (GO:0009799)2.64864892
128regulation of cilium assembly (GO:1902017)2.62488952
129protein refolding (GO:0042026)2.60469791
130gene silencing by RNA (GO:0031047)2.59230285
131centriole replication (GO:0007099)2.58901011
132nuclear pore complex assembly (GO:0051292)2.58197559
133microtubule polymerization or depolymerization (GO:0031109)2.57277428
134regulation of histone H3-K9 methylation (GO:0051570)2.56763951
135microglial cell activation (GO:0001774)2.52057946
136sialylation (GO:0097503)2.51709143
137aldehyde catabolic process (GO:0046185)2.50240207
138regulation of response to osmotic stress (GO:0047484)2.49540949
139pore complex assembly (GO:0046931)2.49477509
140synapsis (GO:0007129)2.47426927
141regulation of collateral sprouting (GO:0048670)2.47389341
142UTP metabolic process (GO:0046051)2.46506780
143organelle assembly (GO:0070925)2.46138230
144brain morphogenesis (GO:0048854)2.45032912
145tolerance induction (GO:0002507)2.43469665
146cytoplasmic microtubule organization (GO:0031122)2.43364767
147regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.43203288
148glycosphingolipid biosynthetic process (GO:0006688)2.42857277
149lateral ventricle development (GO:0021670)2.41626633
150protein import into peroxisome matrix (GO:0016558)2.36735358
151photoreceptor cell development (GO:0042461)2.34394848
152adaptation of signaling pathway (GO:0023058)2.31437633
153negative regulation of adaptive immune response (GO:0002820)2.28686533
154regulation of vacuole organization (GO:0044088)2.28425876
155tryptophan catabolic process (GO:0006569)2.28196560
156indolalkylamine catabolic process (GO:0046218)2.28196560
157sperm motility (GO:0030317)11.3753725
158fusion of sperm to egg plasma membrane (GO:0007342)11.1171300
159axonemal dynein complex assembly (GO:0070286)10.8646763
160cilium or flagellum-dependent cell motility (GO:0001539)10.5318629
161cell wall macromolecule metabolic process (GO:0044036)10.0630777
162cell wall macromolecule catabolic process (GO:0016998)10.0630777
163acrosome reaction (GO:0007340)10.0586803
164motile cilium assembly (GO:0044458)10.0029452

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse8.89221450
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.16236025
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.74853860
4EZH2_22144423_ChIP-Seq_EOC_Human3.46818016
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.41292030
6ZNF274_21170338_ChIP-Seq_K562_Hela3.23068544
7IGF1R_20145208_ChIP-Seq_DFB_Human2.80196224
8* VDR_22108803_ChIP-Seq_LS180_Human2.75666406
9PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.52270301
10CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.50745801
11STAT6_21828071_ChIP-Seq_BEAS2B_Human2.34348985
12GATA1_26923725_Chip-Seq_HPCs_Mouse2.17271097
13GBX2_23144817_ChIP-Seq_PC3_Human2.11337971
14CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.11029614
15CTBP1_25329375_ChIP-Seq_LNCAP_Human2.08849738
16CTBP2_25329375_ChIP-Seq_LNCAP_Human2.03423444
17ER_23166858_ChIP-Seq_MCF-7_Human1.92349649
18FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.86946789
19FLI1_27457419_Chip-Seq_LIVER_Mouse1.86461970
20EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.86410195
21BCAT_22108803_ChIP-Seq_LS180_Human1.85307906
22PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.83923430
23FUS_26573619_Chip-Seq_HEK293_Human1.80508630
24FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.80490494
25IRF8_27001747_Chip-Seq_BMDM_Mouse1.80066253
26GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.76541446
27GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.76398304
28ELK4_26923725_Chip-Seq_MESODERM_Mouse1.76121073
29E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.74689710
30DROSHA_22980978_ChIP-Seq_HELA_Human1.66949033
31POU3F2_20337985_ChIP-ChIP_501MEL_Human1.64699241
32CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.63141827
33ZFP57_27257070_Chip-Seq_ESCs_Mouse1.62222772
34AR_21572438_ChIP-Seq_LNCaP_Human1.57849004
35PCGF2_27294783_Chip-Seq_ESCs_Mouse1.56009987
36NR3C1_21868756_ChIP-Seq_MCF10A_Human1.55193550
37P300_19829295_ChIP-Seq_ESCs_Human1.54265634
38EWS_26573619_Chip-Seq_HEK293_Human1.53621846
39FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.53029207
40STAT3_23295773_ChIP-Seq_U87_Human1.52043826
41STAT1_17558387_ChIP-Seq_HELA_Human1.51791166
42SMAD4_21799915_ChIP-Seq_A2780_Human1.49520050
43AHR_22903824_ChIP-Seq_MCF-7_Human1.46605687
44ESR1_20079471_ChIP-ChIP_T-47D_Human1.44739106
45MYB_26560356_Chip-Seq_TH2_Human1.44110492
46WDR5_24793694_ChIP-Seq_LNCAP_Human1.43243223
47STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.43054266
48TOP2B_26459242_ChIP-Seq_MCF-7_Human1.42253588
49ARNT_22903824_ChIP-Seq_MCF-7_Human1.41390337
50SOX2_22085726_ChIP-Seq_NPCs_Mouse1.40571795
51PIAS1_25552417_ChIP-Seq_VCAP_Human1.40434774
52MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.40039432
53AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.39084653
54IRF8_21731497_ChIP-ChIP_J774_Mouse1.38896421
55IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.38028744
56TCF4_23295773_ChIP-Seq_U87_Human1.37993025
57PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.37644260
58PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.36969714
59NCOR_22424771_ChIP-Seq_293T_Human1.35225588
60TCF4_22108803_ChIP-Seq_LS180_Human1.34815734
61NANOG_20526341_ChIP-Seq_ESCs_Human1.34798197
62FOXM1_23109430_ChIP-Seq_U2OS_Human1.34194499
63RUNX2_22187159_ChIP-Seq_PCA_Human1.33835076
64GATA3_21867929_ChIP-Seq_CD8_Mouse1.33666407
65MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.33040535
66RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.32916121
67MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.32299000
68SMRT_27268052_Chip-Seq_Bcells_Human1.31339917
69GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.30643961
70KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.30573448
71SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.30540264
72IRF8_22096565_ChIP-ChIP_GC-B_Human1.30199842
73TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.29791064
74TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.29380098
75PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.29359745
76GATA3_21878914_ChIP-Seq_MCF-7_Human1.28625692
77MYC_19829295_ChIP-Seq_ESCs_Human1.28339647
78FOXA1_25329375_ChIP-Seq_VCAP_Human1.27882592
79FOXA1_27270436_Chip-Seq_PROSTATE_Human1.27882592
80TAF15_26573619_Chip-Seq_HEK293_Human1.27602029
81FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.27373770
82SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.26831102
83KAP1_22055183_ChIP-Seq_ESCs_Mouse1.25845766
84UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.24744339
85PRDM14_20953172_ChIP-Seq_ESCs_Human1.24619062
86KLF5_20875108_ChIP-Seq_MESCs_Mouse1.23504851
87ERA_21632823_ChIP-Seq_H3396_Human1.23442530
88FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.23254748
89CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.22588781
90SMAD4_21741376_ChIP-Seq_EPCs_Human1.21834865
91KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.21621371
92SOX2_19829295_ChIP-Seq_ESCs_Human1.21441643
93NANOG_19829295_ChIP-Seq_ESCs_Human1.21441643
94PCGF2_27294783_Chip-Seq_NPCs_Mouse1.21075590
95MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.20975225
96AR_20517297_ChIP-Seq_VCAP_Human1.20571056
97SALL1_21062744_ChIP-ChIP_HESCs_Human1.20225246
98AR_25329375_ChIP-Seq_VCAP_Human1.19714026
99TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18773863
100POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.18773863
101TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.18606697
102OCT4_20526341_ChIP-Seq_ESCs_Human1.18487044
103ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.18235328
104HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.17849251
105MYB_26560356_Chip-Seq_TH1_Human1.17818234
106ETV1_20927104_ChIP-Seq_GIST48_Human1.17725679
107TAL1_26923725_Chip-Seq_HPCs_Mouse1.17011163
108* HOXB7_26014856_ChIP-Seq_BT474_Human1.16642740
109LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.16594651
110SCL_19346495_ChIP-Seq_HPC-7_Human1.16412628
111GATA3_26560356_Chip-Seq_TH2_Human1.16220473
112SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15884416
113SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.15850611
114* VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.15773081
115SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.15653892
116ELF1_20517297_ChIP-Seq_JURKAT_Human1.15574480
117NFE2_27457419_Chip-Seq_LIVER_Mouse1.14861689
118PHF8_20622853_ChIP-Seq_HELA_Human1.14298496
119GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.13292674
120GF1_26923725_Chip-Seq_HPCs_Mouse1.13282989
121* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.13080274
122TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.12901693
123HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.12661960
124CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.12652514
125Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.12518641
126SMAD3_21741376_ChIP-Seq_EPCs_Human1.12487971
127GATA3_21867929_ChIP-Seq_TH1_Mouse1.10995765
128TBL1_22424771_ChIP-Seq_293T_Human1.10838901
129IRF1_19129219_ChIP-ChIP_H3396_Human1.10372950
130KDM2B_26808549_Chip-Seq_REH_Human1.10186993
131FOXA1_21572438_ChIP-Seq_LNCaP_Human1.09888432
132PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.08619349
133STAT4_19710469_ChIP-ChIP_TH1__Mouse1.08232109
134TP53_22573176_ChIP-Seq_HFKS_Human1.07689484
135CDX2_22108803_ChIP-Seq_LS180_Human1.07037448
136RUNX1_22412390_ChIP-Seq_EML_Mouse1.06597718
137CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06514677
138BRD4_27068464_Chip-Seq_AML-cells_Mouse1.06483432
139TDRD3_21172665_ChIP-Seq_MCF-7_Human1.06223163
140PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.05875572
141HNFA_21074721_ChIP-Seq_CACO-2_Human1.05334878
142NFYB_21822215_ChIP-Seq_K562_Human1.05290210
143ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.04837437
144EGR1_23403033_ChIP-Seq_LIVER_Mouse1.04313483
145GATA1_19941827_ChIP-Seq_MEL86_Mouse1.03660443
146CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.03098266
147GATA3_27048872_Chip-Seq_THYMUS_Human1.02969590
148* CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02542157
149NOTCH1_21737748_ChIP-Seq_TLL_Human1.02395218
150P53_21459846_ChIP-Seq_SAOS-2_Human1.02170153
151CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.01651191
152* RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.01646810
153CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.01257853
154PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.01232863
155RUNX_20019798_ChIP-Seq_JUKART_Human1.01203906
156NFYA_21822215_ChIP-Seq_K562_Human1.01091214
157PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99957379
158EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.98954353
159LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.98947223
160SPI1_26923725_Chip-Seq_HPCs_Mouse0.97567982
161BCOR_27268052_Chip-Seq_Bcells_Human0.97323715
162RUNX1_26923725_Chip-Seq_HPCs_Mouse0.97230101
163TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.96602258
164SUZ12_27294783_Chip-Seq_NPCs_Mouse0.96178306
165NFIB_24661679_ChIP-Seq_LUNG_Mouse0.94656027
166CBP_20019798_ChIP-Seq_JUKART_Human0.94542321
167IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.94542321
168RARA_24833708_ChIP-Seq_LIVER_Mouse0.93539306
169ERG_20517297_ChIP-Seq_VCAP_Human0.92638514
170IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.91613041
171PHF8_20622854_ChIP-Seq_HELA_Human0.91381154
172ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.90760956
173TCF7_22412390_ChIP-Seq_EML_Mouse0.90641392
174FLI1_21867929_ChIP-Seq_TH2_Mouse0.90035608
175VDR_24787735_ChIP-Seq_THP-1_Human0.88779918
176RAD21_21589869_ChIP-Seq_MESCs_Mouse0.87701986
177CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.87577873
178TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87064281
179RBPJ_22232070_ChIP-Seq_NCS_Mouse0.86989907
180CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.86876575
181MAF_26560356_Chip-Seq_TH1_Human0.86769728
182STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.85784681
183CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.85499934

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive4.69021759
2MP0001929_abnormal_gametogenesis4.45687425
3MP0008875_abnormal_xenobiotic_pharmacok4.43733682
4MP0008877_abnormal_DNA_methylation3.92650447
5MP0001984_abnormal_olfaction2.97686791
6MP0005670_abnormal_white_adipose2.94627408
7MP0002210_abnormal_sex_determination2.83870335
8MP0002653_abnormal_ependyma_morphology2.72700410
9MP0002277_abnormal_respiratory_mucosa2.68296974
10MP0002161_abnormal_fertility/fecundity2.52663091
11MP0004133_heterotaxia2.46906054
12MP0002876_abnormal_thyroid_physiology2.42986225
13MP0004043_abnormal_pH_regulation2.41986315
14MP0001145_abnormal_male_reproductive2.35173634
15MP0002102_abnormal_ear_morphology2.28852973
16MP0005551_abnormal_eye_electrophysiolog2.26645237
17MP0001986_abnormal_taste_sensitivity2.25579278
18MP0002638_abnormal_pupillary_reflex2.10434111
19MP0005410_abnormal_fertilization12.7914328
20MP0000653_abnormal_sex_gland1.99578149
21MP0008995_early_reproductive_senescence1.94753378
22MP0003136_yellow_coat_color1.87054509
23MP0003195_calcinosis1.86115511
24MP0001835_abnormal_antigen_presentation1.82131148
25MP0005253_abnormal_eye_physiology1.74610713
26MP0000569_abnormal_digit_pigmentation1.73403433
27MP0002160_abnormal_reproductive_system1.69448845
28MP0002254_reproductive_system_inflammat1.65472015
29MP0002405_respiratory_system_inflammati1.60672067
30MP0005174_abnormal_tail_pigmentation1.59717173
31MP0009046_muscle_twitch1.59501079
32MP0009780_abnormal_chondrocyte_physiolo1.58720680
33MP0003763_abnormal_thymus_physiology1.50194219
34MP0005671_abnormal_response_to1.48756140
35MP0004019_abnormal_vitamin_homeostasis1.46783786
36MP0005646_abnormal_pituitary_gland1.46620799
37MP0001545_abnormal_hematopoietic_system1.42678563
38MP0005397_hematopoietic_system_phenotyp1.42678563
39MP0001800_abnormal_humoral_immune1.40480020
40MP0001873_stomach_inflammation1.36218740
41MP0009278_abnormal_bone_marrow1.30468327
42MP0008058_abnormal_DNA_repair1.30082266
43MP0002452_abnormal_antigen_presenting1.28619948
44MP0000685_abnormal_immune_system1.24301972
45MP0010094_abnormal_chromosome_stability1.23533223
46MP0000631_abnormal_neuroendocrine_gland1.22889175
47MP0004808_abnormal_hematopoietic_stem1.22841219
48MP0002398_abnormal_bone_marrow1.22717268
49MP0002723_abnormal_immune_serum1.22638585
50MP0002420_abnormal_adaptive_immunity1.21679636
51MP0001819_abnormal_immune_cell1.20664888
52MP0006082_CNS_inflammation1.20353488
53MP0008872_abnormal_physiological_respon1.19881650
54MP0005387_immune_system_phenotype1.18975588
55MP0001790_abnormal_immune_system1.18975588
56MP0003718_maternal_effect1.17974804
57MP0003303_peritoneal_inflammation1.15516119
58MP0002168_other_aberrant_phenotype1.14661537
59MP0000015_abnormal_ear_pigmentation1.14633209
60MP0000465_gastrointestinal_hemorrhage1.14452623
61MP0003183_abnormal_peptide_metabolism1.13920879
62MP0005083_abnormal_biliary_tract1.13834224
63MP0010307_abnormal_tumor_latency1.13806009
64MP0001485_abnormal_pinna_reflex1.13372276
65MP0002132_abnormal_respiratory_system1.12750944
66MP0005645_abnormal_hypothalamus_physiol1.10489680
67MP0000383_abnormal_hair_follicle1.09805530
68MP0010386_abnormal_urinary_bladder1.09777043
69MP0002419_abnormal_innate_immunity1.09189373
70MP0003656_abnormal_erythrocyte_physiolo1.08640999
71MP0005395_other_phenotype1.06407749
72MP0001502_abnormal_circadian_rhythm1.06248450
73MP0005389_reproductive_system_phenotype1.05561579
74MP0005025_abnormal_response_to1.04352208
75MP0006072_abnormal_retinal_apoptosis1.03928543
76MP0001501_abnormal_sleep_pattern1.03079016
77MP0001968_abnormal_touch/_nociception1.02948189
78MP0000716_abnormal_immune_system1.01639890
79MP0005000_abnormal_immune_tolerance1.01354392
80MP0002837_dystrophic_cardiac_calcinosis1.01276498
81MP0002928_abnormal_bile_duct0.98762361
82MP0000689_abnormal_spleen_morphology0.98615416
83MP0002735_abnormal_chemical_nociception0.97897445
84MP0000703_abnormal_thymus_morphology0.96736922
85MP0003111_abnormal_nucleus_morphology0.95040333
86MP0006036_abnormal_mitochondrial_physio0.94509023
87MP0008007_abnormal_cellular_replicative0.93971929
88MP0001270_distended_abdomen0.93559118
89MP0002272_abnormal_nervous_system0.93364516
90MP0005647_abnormal_sex_gland0.90890941
91MP0002229_neurodegeneration0.89970820
92MP0001664_abnormal_digestion0.89526684
93MP0004381_abnormal_hair_follicle0.89401806
94MP0009745_abnormal_behavioral_response0.89150730
95MP0002722_abnormal_immune_system0.88910410
96MP0003693_abnormal_embryo_hatching0.87987719
97MP0001905_abnormal_dopamine_level0.87685983
98MP0002429_abnormal_blood_cell0.87055769
99MP0003786_premature_aging0.86626531
100MP0000372_irregular_coat_pigmentation0.86538995
101MP0001764_abnormal_homeostasis0.86205733
102MP0000427_abnormal_hair_cycle0.86180484
103MP0005464_abnormal_platelet_physiology0.84063255
104MP0003300_gastrointestinal_ulcer0.83606342
105MP0002148_abnormal_hypersensitivity_rea0.82185329
106MP0005195_abnormal_posterior_eye0.82117172
107MP0003436_decreased_susceptibility_to0.81061022
108MP0001970_abnormal_pain_threshold0.80760789
109MP0001919_abnormal_reproductive_system0.78464308
110MP0010678_abnormal_skin_adnexa0.78065909
111MP0009333_abnormal_splenocyte_physiolog0.77138650
112MP0004142_abnormal_muscle_tone0.76566596
113MP0005085_abnormal_gallbladder_physiolo0.76283858
114MP0002166_altered_tumor_susceptibility0.75455528
115MP0008789_abnormal_olfactory_epithelium0.74536939
116MP0008057_abnormal_DNA_replication0.74392433
117MP0009785_altered_susceptibility_to0.73983247
118MP0002138_abnormal_hepatobiliary_system0.71393800
119MP0005377_hearing/vestibular/ear_phenot0.71108818
120MP0003878_abnormal_ear_physiology0.71108818
121MP0001324_abnormal_eye_pigmentation0.70294437
122MP0005394_taste/olfaction_phenotype0.70193669
123MP0005499_abnormal_olfactory_system0.70193669
124MP0000026_abnormal_inner_ear0.69475334
125MP0003077_abnormal_cell_cycle0.69177522
126MP0005365_abnormal_bile_salt0.68622765
127MP0001486_abnormal_startle_reflex0.68554712
128MP0002693_abnormal_pancreas_physiology0.67869092
129MP0005075_abnormal_melanosome_morpholog0.67753303
130MP0004885_abnormal_endolymph0.67588239
131MP0001845_abnormal_inflammatory_respons0.67398431
132MP0001765_abnormal_ion_homeostasis0.67346389
133MP0002909_abnormal_adrenal_gland0.67122904
134MP0002557_abnormal_social/conspecific_i0.66689617
135MP0005391_vision/eye_phenotype0.66676551
136MP0002752_abnormal_somatic_nervous0.66498534
137MP0001963_abnormal_hearing_physiology0.65946665
138MP0001853_heart_inflammation0.65357991
139MP0000490_abnormal_crypts_of0.64860140
140MP0001944_abnormal_pancreas_morphology0.64580832
141MP0002734_abnormal_mechanical_nocicepti0.64388098
142MP0002572_abnormal_emotion/affect_behav0.63850872
143MP0002233_abnormal_nose_morphology0.63664502
144MP0001851_eye_inflammation0.63224077
145MP0002009_preneoplasia0.62594384
146MP0003448_altered_tumor_morphology0.59691453
147MP0009115_abnormal_fat_cell0.59447868
148MP0002282_abnormal_trachea_morphology0.58611240
149MP0005310_abnormal_salivary_gland0.56861159
150MP0008469_abnormal_protein_level0.52911796
151MP0004947_skin_inflammation0.52232205
152MP0001293_anophthalmia0.52182839
153MP0010155_abnormal_intestine_physiology0.50934535
154MP0005623_abnormal_meninges_morphology0.49990117
155MP0000313_abnormal_cell_death0.49933228
156MP0005636_abnormal_mineral_homeostasis0.49541162
157MP0000858_altered_metastatic_potential0.47612410
158MP0003646_muscle_fatigue0.47238713
159MP0003787_abnormal_imprinting0.46119257
160MP0003172_abnormal_lysosome_physiology0.45807167
161MP0002019_abnormal_tumor_incidence0.45516209
162MP0002006_tumorigenesis0.43833877
163MP0003724_increased_susceptibility_to0.43659573
164MP0001119_abnormal_female_reproductive0.43393849
165MP0002396_abnormal_hematopoietic_system0.42917904
166MP0005666_abnormal_adipose_tissue0.41717691

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.69235345
2Abnormal respiratory motile cilium morphology (HP:0005938)8.88436083
3Abnormal respiratory epithelium morphology (HP:0012253)8.88436083
4Abnormal ciliary motility (HP:0012262)8.10654194
5Rhinitis (HP:0012384)8.03770474
6Chronic bronchitis (HP:0004469)7.07097997
7Nasal polyposis (HP:0100582)6.73708605
8Abnormality of the nasal mucosa (HP:0000433)5.53135490
9Infertility (HP:0000789)5.52686491
10Bronchiectasis (HP:0002110)5.30383808
11Bronchitis (HP:0012387)4.88804399
12Recurrent sinusitis (HP:0011108)4.30250789
13Recurrent otitis media (HP:0000403)3.86528381
14Nephronophthisis (HP:0000090)3.82173377
15Recurrent bronchitis (HP:0002837)3.43275333
16Male infertility (HP:0003251)3.00833759
17Abnormality of the renal medulla (HP:0100957)2.97806572
18Abnormal spermatogenesis (HP:0008669)2.90509558
19Absent rod-and cone-mediated responses on ERG (HP:0007688)2.73480356
20Male pseudohermaphroditism (HP:0000037)2.64659200
21Molar tooth sign on MRI (HP:0002419)2.63325990
22Abnormality of midbrain morphology (HP:0002418)2.63325990
23Medial flaring of the eyebrow (HP:0010747)2.53892708
24Anencephaly (HP:0002323)2.52804640
25Tubulointerstitial nephritis (HP:0001970)2.52245360
26Chronic otitis media (HP:0000389)2.51665994
27Chronic sinusitis (HP:0011109)2.45677618
28Impulsivity (HP:0100710)2.44356601
29Aplasia/Hypoplasia of the spleen (HP:0010451)2.42467160
30Asplenia (HP:0001746)2.39072090
31Tubular atrophy (HP:0000092)2.36055339
32Abnormal rod and cone electroretinograms (HP:0008323)2.27233784
33Decreased circulating renin level (HP:0003351)2.23354241
34Tubulointerstitial abnormality (HP:0001969)2.18539260
35Hypoplasia of the capital femoral epiphysis (HP:0003090)2.17602489
36Decreased central vision (HP:0007663)2.14261557
37Sclerocornea (HP:0000647)2.13647186
38Furrowed tongue (HP:0000221)2.12192275
39Hyperactive renin-angiotensin system (HP:0000841)2.09887626
40Azoospermia (HP:0000027)2.06060310
41Gonadotropin excess (HP:0000837)2.04814014
42Congenital hepatic fibrosis (HP:0002612)2.00390474
43Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.6766404
44Dynein arm defect of respiratory motile cilia (HP:0012255)11.1533317
45Absent/shortened dynein arms (HP:0200106)11.1533317
46Retrobulbar optic neuritis (HP:0100654)1.95631071
47Optic neuritis (HP:0100653)1.95631071
48Tubulointerstitial fibrosis (HP:0005576)1.94484579
49Atelectasis (HP:0100750)1.93492862
50Bile duct proliferation (HP:0001408)1.91883813
51Abnormal biliary tract physiology (HP:0012439)1.91883813
52Polyuria (HP:0000103)1.88693151
53Pancreatic fibrosis (HP:0100732)1.87904063
54Absent speech (HP:0001344)1.87891558
55Postaxial foot polydactyly (HP:0001830)1.79378670
56True hermaphroditism (HP:0010459)1.77045867
57Congenital stationary night blindness (HP:0007642)1.75713668
58J-shaped sella turcica (HP:0002680)1.74189672
59Abolished electroretinogram (ERG) (HP:0000550)1.72950905
60Absent epiphyses (HP:0010577)1.68385863
61Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.68385863
62Genital tract atresia (HP:0001827)1.66386788
63Heterotopia (HP:0002282)1.65291244
64Cystic liver disease (HP:0006706)1.65262581
65Congenital primary aphakia (HP:0007707)1.64310746
66Preaxial hand polydactyly (HP:0001177)1.62239322
67Abnormality of the renal cortex (HP:0011035)1.61632399
68Vaginal atresia (HP:0000148)1.61523852
69Deformed sella turcica (HP:0002681)1.61272405
70Orchitis (HP:0100796)1.60272616
71Dyschromatopsia (HP:0007641)1.59455524
72Abnormality of macular pigmentation (HP:0008002)1.59233126
73Gait imbalance (HP:0002141)1.57803354
74Abnormality of renin-angiotensin system (HP:0000847)1.57074802
75Retinitis pigmentosa (HP:0000510)1.56137852
76Oculomotor apraxia (HP:0000657)1.54715319
77Attenuation of retinal blood vessels (HP:0007843)1.54349732
78Recurrent abscess formation (HP:0002722)1.52265938
79Type II lissencephaly (HP:0007260)1.50762749
80Bony spicule pigmentary retinopathy (HP:0007737)1.50532430
81Abnormality of the dental root (HP:0006486)1.50433079
82Taurodontia (HP:0000679)1.50433079
83Abnormality of permanent molar morphology (HP:0011071)1.50433079
84Nephrogenic diabetes insipidus (HP:0009806)1.49997137
85Constricted visual fields (HP:0001133)1.49695157
86Myositis (HP:0100614)1.49477149
87Median cleft lip (HP:0000161)1.48917420
88Stage 5 chronic kidney disease (HP:0003774)1.47662839
89Abnormal urine output (HP:0012590)1.46854380
90Renal salt wasting (HP:0000127)1.46632699
91Narrow forehead (HP:0000341)1.44717673
92Abnormal drinking behavior (HP:0030082)1.40637641
93Polydipsia (HP:0001959)1.40637641
94Postaxial hand polydactyly (HP:0001162)1.40339233
95Hyperventilation (HP:0002883)1.39958380
96Hyperaldosteronism (HP:0000859)1.38973069
97Aplasia/Hypoplasia of the lens (HP:0008063)1.38592927
98Poor coordination (HP:0002370)1.37942913
99Facial cleft (HP:0002006)1.37936483
100Abnormality of molar morphology (HP:0011070)1.37490331
101Abnormality of molar (HP:0011077)1.37490331
102Fibular hypoplasia (HP:0003038)1.37427983
103Prominent nasal bridge (HP:0000426)1.36979692
104Poikilocytosis (HP:0004447)1.36251379
105Abnormality of the dental pulp (HP:0006479)1.36100144
106Pancreatic cysts (HP:0001737)1.34329834
107Recurrent bacterial skin infections (HP:0005406)1.33829796
108Hypoplasia of the uterus (HP:0000013)1.33265644
109Multicystic kidney dysplasia (HP:0000003)1.32243461
110Absent frontal sinuses (HP:0002688)1.31781913
111Inflammation of the large intestine (HP:0002037)1.31385561
112Hypomagnesemia (HP:0002917)1.31370340
113Supernumerary spleens (HP:0009799)1.30360245
114Aganglionic megacolon (HP:0002251)1.28329702
115Abnormality of renal excretion (HP:0011036)1.27441354
116Hypokalemic alkalosis (HP:0001949)1.27350247
117Stomatitis (HP:0010280)1.27093774
118Hemorrhage of the eye (HP:0011885)1.24249984
119Macular degeneration (HP:0000608)1.23360359
120Truncal obesity (HP:0001956)1.23269464
121Cone-rod dystrophy (HP:0000548)1.22946563
122Renal cortical cysts (HP:0000803)1.22402142
123Nephropathy (HP:0000112)1.21171672
124Autoimmune thrombocytopenia (HP:0001973)1.20915680
125Thyroid-stimulating hormone excess (HP:0002925)1.20863487
126Short femoral neck (HP:0100864)1.20729882
127Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.20597919
128B lymphocytopenia (HP:0010976)1.20500097
129Abnormality of B cell number (HP:0010975)1.20500097
130Colitis (HP:0002583)1.20188915
131Aplasia/Hypoplasia of the tongue (HP:0010295)1.20114169
132Cerebellar dysplasia (HP:0007033)1.20111634
133Gastrointestinal inflammation (HP:0004386)1.19765723
134Arterial thrombosis (HP:0004420)1.19765084
135Oligohydramnios (HP:0001562)1.19645913
136Choroideremia (HP:0001139)1.18570323
137Thyroiditis (HP:0100646)1.18087429
138Short ribs (HP:0000773)1.17882754
139Occipital encephalocele (HP:0002085)1.17595907
140Eczematoid dermatitis (HP:0000976)1.17521515
141Recurrent fungal infections (HP:0002841)1.17276309
142Abnormality of the sella turcica (HP:0002679)1.16822299
143Chronic hepatic failure (HP:0100626)1.16131425
144Impaired proprioception (HP:0010831)1.16121287
145Short thorax (HP:0010306)1.15046361

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK36.76421243
2PDK46.76421243
3TESK15.16021177
4PDK24.82660506
5PINK14.82226723
6FRK4.69146026
7ICK3.69101519
8PRKD33.59472408
9MAPK153.38895621
10MAP3K102.29357035
11ADRBK22.16913396
12MAPKAPK32.13078030
13MAP4K22.02839209
14NEK22.02427476
15WNK31.88439354
16MAP3K41.79705735
17MAP4K11.69926973
18TGFBR21.68180310
19PTK2B1.68048020
20MAPK131.68021408
21PNCK1.63882735
22BMPR1B1.58830511
23MAP2K71.55294056
24STK101.53556092
25TXK1.52799373
26OXSR11.50303498
27TRIM281.49421396
28GRK11.47775400
29DYRK1B1.47402320
30BCR1.46319022
31CAMK1G1.30424210
32NME11.25863081
33STK381.24562760
34CDK121.20329122
35EEF2K1.14655557
36PDK11.11390723
37DYRK31.02076491
38WNK40.98647874
39STK30.98204836
40CSNK1A1L0.96217500
41LATS10.93831024
42INSRR0.91802833
43CSNK1G30.91716242
44ACVR1B0.91433877
45IRAK10.90310429
46MAP3K130.89734200
47ZAP700.89155060
48NLK0.88164571
49MAP3K70.84748317
50IKBKE0.84447995
51STK390.84230608
52CAMK1D0.83468041
53EPHA20.82896888
54ITK0.81536152
55CSNK1G20.80405028
56CSNK1G10.79828336
57TBK10.79462581
58EIF2AK30.78112623
59CASK0.75303187
60BRD40.72695146
61PRKCI0.72514640
62RIPK40.71271843
63VRK10.70528606
64ERBB30.69988659
65TLK10.69534452
66TYK20.68048531
67LMTK20.67961702
68FGFR20.67768800
69CDK190.67387236
70CAMKK10.67129726
71CDC70.67013262
72CSK0.66640885
73PIM10.66157207
74GRK60.65208261
75SIK30.64241190
76FGFR30.63758838
77ADRBK10.63502460
78NUAK10.61806949
79CSF1R0.60588756
80MAP3K20.60089367
81EPHA30.59193849
82STK40.59170771
83CDK30.58827445
84ATR0.58631262
85NEK60.57416093
86BTK0.57323903
87BLK0.55975268
88PAK30.55303680
89PRKCE0.55292509
90PRKAA20.55122936
91MUSK0.53980795
92STK38L0.53912965
93PLK20.53888369
94CHEK20.53419249
95MST40.52923953
96SGK4940.52532341
97SGK2230.52532341
98TEC0.52460675
99WNK10.52239256
100CDK90.51472276
101STK240.50903994
102ZAK0.49890122
103PDPK10.49734538
104TTK0.49037371
105LCK0.48875777
106SYK0.48155152
107HCK0.47426081
108EIF2AK10.46416608
109DYRK20.46249737
110SGK20.45138672
111TRPM70.43841974
112YES10.43115764
113CDK60.42542403
114PKN10.41908208
115CHEK10.41695655
116MARK30.41287947
117CCNB10.41144097
118PRKCQ0.40883506
119ABL10.39274259
120MARK20.38645255
121CAMK10.38597353
122ATM0.38272472
123CSNK1A10.36349849
124PRKACA0.35983718
125IKBKB0.35976771
126TNIK0.35892964
127SIK20.35779757
128GRK70.35616075
129JAK10.35473669
130CLK10.35051292
131JAK30.34426252
132LYN0.34408347
133CDK40.34306264
134STK110.32710101
135TNK20.31361609
136BRSK20.31321327
137CAMKK20.30908167
138KIT0.30101912
139NTRK20.29274357
140CSNK1D0.28592009
141CHUK0.28555686
142PLK10.28395072
143MAPK70.28136797
144TAOK30.27791798
145PASK0.26569701
146MAP3K140.26061345
147TYRO30.23011961
148PIM20.22847128
149RIPK10.22428724
150STK160.21625087
151PLK40.21262384
152MTOR0.21042210
153IRAK20.20967662
154IRAK40.20845815
155MAPKAPK20.20141078
156RPS6KA40.19517101
157RPS6KB10.17936542
158PAK10.15270652
159EGFR0.15189544
160PRKAA10.14975275
161PAK40.14560584
162RPS6KA50.13990799
163MAP3K30.13354632
164AURKB0.12465437

Predicted pathways (KEGG)

RankGene SetZ-score
1Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009803.55047237
2Vitamin B6 metabolism_Homo sapiens_hsa007503.48669157
3Chemical carcinogenesis_Homo sapiens_hsa052043.32283152
4Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.16072602
5Fatty acid biosynthesis_Homo sapiens_hsa000613.10014181
6Histidine metabolism_Homo sapiens_hsa003402.49441518
7Phototransduction_Homo sapiens_hsa047442.48979276
8Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.48210494
9Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.33174959
10Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.25283761
11Caffeine metabolism_Homo sapiens_hsa002322.23481010
12Systemic lupus erythematosus_Homo sapiens_hsa053222.13731875
13Olfactory transduction_Homo sapiens_hsa047402.12296821
14beta-Alanine metabolism_Homo sapiens_hsa004102.11023017
15Antigen processing and presentation_Homo sapiens_hsa046122.09521061
16Pyruvate metabolism_Homo sapiens_hsa006202.09079210
17Fanconi anemia pathway_Homo sapiens_hsa034602.08020525
18Basal transcription factors_Homo sapiens_hsa030222.01718140
19Primary immunodeficiency_Homo sapiens_hsa053401.99876879
20Nitrogen metabolism_Homo sapiens_hsa009101.99833344
21Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.97510312
22B cell receptor signaling pathway_Homo sapiens_hsa046621.93648994
23Retinol metabolism_Homo sapiens_hsa008301.90549164
24Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.89152507
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.80153513
26Phenylalanine metabolism_Homo sapiens_hsa003601.79416994
27Glycosaminoglycan degradation_Homo sapiens_hsa005311.77077408
28Glucagon signaling pathway_Homo sapiens_hsa049221.75483222
29Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.74046552
30Tyrosine metabolism_Homo sapiens_hsa003501.73447233
31Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.72258459
32alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.72005008
33Butanoate metabolism_Homo sapiens_hsa006501.71066964
34Carbohydrate digestion and absorption_Homo sapiens_hsa049731.69115018
35Steroid hormone biosynthesis_Homo sapiens_hsa001401.68493208
36Circadian rhythm_Homo sapiens_hsa047101.64845216
37Peroxisome_Homo sapiens_hsa041461.62170105
38Huntingtons disease_Homo sapiens_hsa050161.61361572
39Measles_Homo sapiens_hsa051621.60565710
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.60388112
41Glutathione metabolism_Homo sapiens_hsa004801.55706081
42Regulation of autophagy_Homo sapiens_hsa041401.55157342
43T cell receptor signaling pathway_Homo sapiens_hsa046601.52669361
44Linoleic acid metabolism_Homo sapiens_hsa005911.48690948
45Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.43453730
46Osteoclast differentiation_Homo sapiens_hsa043801.38962316
47Other glycan degradation_Homo sapiens_hsa005111.38451001
48Sphingolipid metabolism_Homo sapiens_hsa006001.35880158
49Dorso-ventral axis formation_Homo sapiens_hsa043201.34484015
50Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.34389514
51Collecting duct acid secretion_Homo sapiens_hsa049661.33559612
52Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.32592340
53Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.32532445
54Hematopoietic cell lineage_Homo sapiens_hsa046401.31668783
55Selenocompound metabolism_Homo sapiens_hsa004501.30865893
56Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.29891591
57Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.26427978
58Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.19699062
59Legionellosis_Homo sapiens_hsa051341.19373493
60NF-kappa B signaling pathway_Homo sapiens_hsa040641.19357919
61Viral carcinogenesis_Homo sapiens_hsa052031.18728939
62Taste transduction_Homo sapiens_hsa047421.18183978
63mRNA surveillance pathway_Homo sapiens_hsa030151.17573865
64Pentose phosphate pathway_Homo sapiens_hsa000301.17393101
65Glycerophospholipid metabolism_Homo sapiens_hsa005641.16107194
66Mineral absorption_Homo sapiens_hsa049781.15916132
67Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.15383360
68Intestinal immune network for IgA production_Homo sapiens_hsa046721.12193700
69Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.11632268
70Glycerolipid metabolism_Homo sapiens_hsa005611.07966956
71Nicotine addiction_Homo sapiens_hsa050331.07421555
72Influenza A_Homo sapiens_hsa051641.06496984
73Herpes simplex infection_Homo sapiens_hsa051681.06094618
74Tryptophan metabolism_Homo sapiens_hsa003801.02456657
75Propanoate metabolism_Homo sapiens_hsa006401.00843020
76Alcoholism_Homo sapiens_hsa050340.94299375
77Hedgehog signaling pathway_Homo sapiens_hsa043400.93015677
78Toxoplasmosis_Homo sapiens_hsa051450.92886355
79Allograft rejection_Homo sapiens_hsa053300.92826706
80Jak-STAT signaling pathway_Homo sapiens_hsa046300.91586661
81Salivary secretion_Homo sapiens_hsa049700.90986709
82Oocyte meiosis_Homo sapiens_hsa041140.89160460
83Maturity onset diabetes of the young_Homo sapiens_hsa049500.88856571
84Fatty acid degradation_Homo sapiens_hsa000710.87339934
85Autoimmune thyroid disease_Homo sapiens_hsa053200.87149533
86Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.86180107
87Ether lipid metabolism_Homo sapiens_hsa005650.83607334
88Epstein-Barr virus infection_Homo sapiens_hsa051690.83514807
89Purine metabolism_Homo sapiens_hsa002300.82354736
90RNA degradation_Homo sapiens_hsa030180.82084877
91Non-homologous end-joining_Homo sapiens_hsa034500.81811313
92PPAR signaling pathway_Homo sapiens_hsa033200.80081161
93Type I diabetes mellitus_Homo sapiens_hsa049400.78506057
94Amphetamine addiction_Homo sapiens_hsa050310.78409806
95Staphylococcus aureus infection_Homo sapiens_hsa051500.78043313
96Phosphatidylinositol signaling system_Homo sapiens_hsa040700.77348648
97Primary bile acid biosynthesis_Homo sapiens_hsa001200.75734398
98Asthma_Homo sapiens_hsa053100.75594813
99ABC transporters_Homo sapiens_hsa020100.75225172
100Transcriptional misregulation in cancer_Homo sapiens_hsa052020.75131899
101Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.72242655
102Renin-angiotensin system_Homo sapiens_hsa046140.72196257
103SNARE interactions in vesicular transport_Homo sapiens_hsa041300.72117686
104Arachidonic acid metabolism_Homo sapiens_hsa005900.70695746
105Leishmaniasis_Homo sapiens_hsa051400.70288795
106Inositol phosphate metabolism_Homo sapiens_hsa005620.70148583
107Tuberculosis_Homo sapiens_hsa051520.69316192
108Cell cycle_Homo sapiens_hsa041100.69158683
109RNA transport_Homo sapiens_hsa030130.66542078
110Protein export_Homo sapiens_hsa030600.65627405
111Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.65161546
112HTLV-I infection_Homo sapiens_hsa051660.64715392
113Endocytosis_Homo sapiens_hsa041440.64011430
114Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.62474388
115Rheumatoid arthritis_Homo sapiens_hsa053230.61966276
116Hepatitis B_Homo sapiens_hsa051610.61053779
117Renin secretion_Homo sapiens_hsa049240.60454062
118Fructose and mannose metabolism_Homo sapiens_hsa000510.59821551
119Ovarian steroidogenesis_Homo sapiens_hsa049130.56571861
120Morphine addiction_Homo sapiens_hsa050320.55669113
121Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.55540378
122Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.55379950
123Apoptosis_Homo sapiens_hsa042100.55249931
124Malaria_Homo sapiens_hsa051440.54058295
125Toll-like receptor signaling pathway_Homo sapiens_hsa046200.53958312
126Salmonella infection_Homo sapiens_hsa051320.53149437
127Metabolic pathways_Homo sapiens_hsa011000.53139085
128Adipocytokine signaling pathway_Homo sapiens_hsa049200.52130690
129DNA replication_Homo sapiens_hsa030300.51589311
130Pentose and glucuronate interconversions_Homo sapiens_hsa000400.47357702
131cGMP-PKG signaling pathway_Homo sapiens_hsa040220.47332831
132Estrogen signaling pathway_Homo sapiens_hsa049150.47041703
133Thyroid hormone signaling pathway_Homo sapiens_hsa049190.46526542
134Homologous recombination_Homo sapiens_hsa034400.46276444
135RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.45231241
136Phagosome_Homo sapiens_hsa041450.44389680
137Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.44272722
138Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.44169952
139Vitamin digestion and absorption_Homo sapiens_hsa049770.43948032
140Drug metabolism - other enzymes_Homo sapiens_hsa009830.43392142
141Graft-versus-host disease_Homo sapiens_hsa053320.42989007
142Acute myeloid leukemia_Homo sapiens_hsa052210.41866465
143Serotonergic synapse_Homo sapiens_hsa047260.41730412
144Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.41652655
145N-Glycan biosynthesis_Homo sapiens_hsa005100.40051534
146Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.39375569
147Base excision repair_Homo sapiens_hsa034100.39287226
148Fat digestion and absorption_Homo sapiens_hsa049750.39265682
149Starch and sucrose metabolism_Homo sapiens_hsa005000.38748837
150Oxidative phosphorylation_Homo sapiens_hsa001900.38349541
151Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.38042687
152Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.38020126
153Shigellosis_Homo sapiens_hsa051310.36905363
154Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.36712207
155Calcium signaling pathway_Homo sapiens_hsa040200.34784002
156Chemokine signaling pathway_Homo sapiens_hsa040620.34307387
157TNF signaling pathway_Homo sapiens_hsa046680.33447565
158Pyrimidine metabolism_Homo sapiens_hsa002400.32716346
159Circadian entrainment_Homo sapiens_hsa047130.31410038
160RNA polymerase_Homo sapiens_hsa030200.27458208
161Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.26589466
162NOD-like receptor signaling pathway_Homo sapiens_hsa046210.25544122
163Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.25367818
164Tight junction_Homo sapiens_hsa045300.23941085
165cAMP signaling pathway_Homo sapiens_hsa040240.23401870
166Insulin secretion_Homo sapiens_hsa049110.20692857
167GABAergic synapse_Homo sapiens_hsa047270.18313159

Most similar genes based on co-expression Upload to Enrichr

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