ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	7.53856002
2	negative regulation of inclusion body assembly (GO:0090084)	7.53331061
3	protein refolding (GO:0042026)	7.25095544
4	chaperone mediated protein folding requiring cofactor (GO:0051085)	6.14842319
5	sequestering of actin monomers (GO:0042989)	5.68417241
6	regulation of immunoglobulin secretion (GO:0051023)	5.09479011
7	response to gravity (GO:0009629)	4.71767197
8	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	4.69616912
9	isotype switching (GO:0045190)	4.69616912
10	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	4.69616912
11	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	4.47018900
12	cellular response to exogenous dsRNA (GO:0071360)	4.45585624
13	negative regulation of mast cell activation (GO:0033004)	4.42783992
14	positive regulation of endothelial cell apoptotic process (GO:2000353)	4.35533758
15	positive regulation of phosphoprotein phosphatase activity (GO:0032516)	4.31641043
16	regulation of inclusion body assembly (GO:0090083)	4.16778268
17	negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)	4.16481470
18	cytidine deamination (GO:0009972)	4.12685937
19	cytidine metabolic process (GO:0046087)	4.12685937
20	cytidine catabolic process (GO:0006216)	4.12685937
21	protein neddylation (GO:0045116)	4.11558590
22	sulfation (GO:0051923)	4.04348746
23	cellular response to dsRNA (GO:0071359)	4.03656582
24	Arp2/3 complex-mediated actin nucleation (GO:0034314)	4.01113439
25	negative T cell selection (GO:0043383)	3.93120246
26	positive regulation of mitochondrial fission (GO:0090141)	3.85448891
27	sleep (GO:0030431)	3.77733589
28	spinal cord development (GO:0021510)	3.75860577
29	actin nucleation (GO:0045010)	3.73406506
30	pyrimidine ribonucleoside catabolic process (GO:0046133)	3.57919167
31	positive T cell selection (GO:0043368)	3.46933939
32	glycerol metabolic process (GO:0006071)	3.39070102
33	negative thymic T cell selection (GO:0045060)	3.30809469
34	positive regulation of calcium-mediated signaling (GO:0050850)	3.23950797
35	viral protein processing (GO:0019082)	3.22636509
36	endocardial cushion morphogenesis (GO:0003203)	3.17126703
37	protein-cofactor linkage (GO:0018065)	3.16947555
38	behavioral response to nicotine (GO:0035095)	3.16584090
39	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.14509484
40	myoblast migration (GO:0051451)	3.13576465
41	purine ribonucleoside bisphosphate metabolic process (GO:0034035)	3.12028883
42	3-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)	3.12028883
43	somite development (GO:0061053)	3.10729596
44	regulation of hexokinase activity (GO:1903299)	3.07879069
45	regulation of glucokinase activity (GO:0033131)	3.07879069
46	somatic diversification of immunoglobulins (GO:0016445)	3.02521929
47	cell proliferation in forebrain (GO:0021846)	2.98343606
48	neuron fate determination (GO:0048664)	2.97736245
49	alanine transport (GO:0032328)	2.96118597
50	somatic recombination of immunoglobulin gene segments (GO:0016447)	2.93709850
51	alditol metabolic process (GO:0019400)	2.93512767
52	negative regulation of interleukin-1 beta production (GO:0032691)	2.91884060
53	platelet dense granule organization (GO:0060155)	2.86332079
54	regulation of mitochondrial fission (GO:0090140)	2.82587690
55	positive regulation of alpha-beta T cell proliferation (GO:0046641)	2.80158285
56	proteasome assembly (GO:0043248)	2.80075541
57	positive thymic T cell selection (GO:0045059)	2.79952782
58	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.78591352
59	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.78591352
60	otic vesicle formation (GO:0030916)	2.76208661
61	regulation of defense response to virus by host (GO:0050691)	2.75577431
62	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	2.75001580
63	nephron epithelium morphogenesis (GO:0072088)	2.72192800
64	nephron tubule morphogenesis (GO:0072078)	2.72192800
65	positive regulation of T cell migration (GO:2000406)	2.72104521
66	cell proliferation involved in metanephros development (GO:0072203)	2.70598281
67	limb bud formation (GO:0060174)	2.69207759
68	regulation of cardioblast proliferation (GO:0003264)	2.67636252
69	regulation of secondary heart field cardioblast proliferation (GO:0003266)	2.67636252
70	cornea development in camera-type eye (GO:0061303)	2.67557110
71	B cell activation involved in immune response (GO:0002312)	2.65091445
72	positive regulation of interleukin-12 production (GO:0032735)	2.64221014
73	mesenchyme morphogenesis (GO:0072132)	2.64172360
74	intracellular protein transmembrane import (GO:0044743)	2.63455664
75	cellular response to arsenic-containing substance (GO:0071243)	2.63205759
76	regulation of T cell receptor signaling pathway (GO:0050856)	2.63107564
77	cell proliferation involved in kidney development (GO:0072111)	2.62472406
78	hindbrain development (GO:0030902)	2.61137247
79	negative regulation of interleukin-1 production (GO:0032692)	2.59715519
80	piRNA metabolic process (GO:0034587)	2.59373359
81	regulation of regulatory T cell differentiation (GO:0045589)	2.58862940
82	synapsis (GO:0007129)	2.56022340
83	thymic T cell selection (GO:0045061)	2.54908179
84	nephron tubule formation (GO:0072079)	2.54270320
85	T cell selection (GO:0045058)	2.53329014
86	potassium ion import (GO:0010107)	2.52924479
87	neural crest cell development (GO:0014032)	2.52686280
88	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.50601163
89	heart valve formation (GO:0003188)	2.47575460
90	pyrimidine dimer repair (GO:0006290)	2.46109909
91	regulation of timing of cell differentiation (GO:0048505)	2.43024706
92	regulation of penile erection (GO:0060405)	2.41686882
93	regulation of alpha-beta T cell proliferation (GO:0046640)	2.41181763
94	regulation of calcium-mediated signaling (GO:0050848)	2.39502360
95	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.38108686
96	ATP synthesis coupled proton transport (GO:0015986)	2.38108686
97	neuronal action potential (GO:0019228)	2.36775784
98	regulation of glucocorticoid secretion (GO:2000849)	2.35807399
99	iron-sulfur cluster assembly (GO:0016226)	2.34993578
100	metallo-sulfur cluster assembly (GO:0031163)	2.34993578

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.40459338
2	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	4.36245445
3	EZH2_22144423_ChIP-Seq_EOC_Human	4.31860680
4	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	3.88068254
5	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	3.18964599
6	VDR_22108803_ChIP-Seq_LS180_Human	2.87344325
7	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.69651609
8	EED_16625203_ChIP-ChIP_MESCs_Mouse	2.59473193
9	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.44007723
10	ZNF274_21170338_ChIP-Seq_K562_Hela	2.43703516
11	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	2.25829874
12	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.14403204
13	TRIM28_21343339_ChIP-Seq_HEK293_Human	2.12085840
14	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.10632737
15	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.03859318
16	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.00722397
17	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.99480281
18	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.93255213
19	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.90570513
20	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.84965103
21	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.84627968
22	RUNX_20019798_ChIP-Seq_JUKART_Human	1.82732986
23	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.80221537
24	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.79640991
25	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.79431703
26	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.74894846
27	TP53_22573176_ChIP-Seq_HFKS_Human	1.71441740
28	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.69225886
29	VDR_23849224_ChIP-Seq_CD4+_Human	1.67956550
30	MYC_18940864_ChIP-ChIP_HL60_Human	1.61130821
31	EWS_26573619_Chip-Seq_HEK293_Human	1.58474252
32	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.54151149
33	ELK1_19687146_ChIP-ChIP_HELA_Human	1.53325641
34	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.51686247
35	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.49902569
36	IGF1R_20145208_ChIP-Seq_DFB_Human	1.49210864
37	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.45718320
38	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.45518641
39	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.44391012
40	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.43081382
41	ER_23166858_ChIP-Seq_MCF-7_Human	1.42812984
42	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.38650420
43	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.32337363
44	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.30804972
45	GATA3_26560356_Chip-Seq_TH2_Human	1.27631310
46	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.27616716
47	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.27585798
48	P300_19829295_ChIP-Seq_ESCs_Human	1.26899254
49	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	1.26240039
50	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.25940150
51	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.24530130
52	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.24060643
53	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.22601329
54	IRF1_19129219_ChIP-ChIP_H3396_Human	1.17503278
55	GBX2_23144817_ChIP-Seq_PC3_Human	1.13629390
56	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.12663267
57	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.12554459
58	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.09703073
59	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.08877121
60	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.08437498
61	KAP1_22055183_ChIP-Seq_ESCs_Mouse	1.06350673
62	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.05924340
63	RNF2_27304074_Chip-Seq_NSC_Mouse	1.05571053
64	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.02661692
65	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.01835429
66	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.01835429
67	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.01819125
68	CBP_20019798_ChIP-Seq_JUKART_Human	1.01186573
69	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.01186573
70	CTCF_20526341_ChIP-Seq_ESCs_Human	1.00886388
71	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.99972364
72	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	0.99165324
73	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	0.98856352
74	AR_21572438_ChIP-Seq_LNCaP_Human	0.98693017
75	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.98179227
76	MYC_19829295_ChIP-Seq_ESCs_Human	0.97874296
77	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.97285873
78	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.97285873
79	TP53_20018659_ChIP-ChIP_R1E_Mouse	0.97093055
80	FLI1_27457419_Chip-Seq_LIVER_Mouse	0.96925846
81	NANOG_19829295_ChIP-Seq_ESCs_Human	0.95782638
82	SOX2_19829295_ChIP-Seq_ESCs_Human	0.95782638
83	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.95363547
84	ETS1_20019798_ChIP-Seq_JURKAT_Human	0.95287004
85	NCOR_22424771_ChIP-Seq_293T_Human	0.94983937
86	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	0.94943575
87	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.93908832
88	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.91859115
89	NANOG_20526341_ChIP-Seq_ESCs_Human	0.91143452
90	RNF2_27304074_Chip-Seq_ESCs_Mouse	0.90901970
91	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.90753432
92	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	0.90168521
93	GATA3_27048872_Chip-Seq_THYMUS_Human	0.89906049
94	ATF3_23680149_ChIP-Seq_GBM1-GSC_Human	0.89569517
95	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.89552966
96	HOXB7_26014856_ChIP-Seq_BT474_Human	0.87866289
97	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.85638913
98	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.84088508
99	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.80778267
100	AR_25329375_ChIP-Seq_VCAP_Human	0.80690227

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003283_abnormal_digestive_organ	5.07724151
2	MP0003136_yellow_coat_color	3.75517054
3	MP0006072_abnormal_retinal_apoptosis	3.15236724
4	MP0002009_preneoplasia	2.94913690
5	MP0005671_abnormal_response_to	2.70056835
6	MP0003329_amyloid_beta_deposits	2.54715074
7	MP0000049_abnormal_middle_ear	2.46415692
8	MP0004885_abnormal_endolymph	2.39009087
9	MP0009384_cardiac_valve_regurgitation	2.30218879
10	MP0009780_abnormal_chondrocyte_physiolo	2.26728292
11	MP0000604_amyloidosis	2.20312972
12	MP0003806_abnormal_nucleotide_metabolis	2.14051567
13	MP0004147_increased_porphyrin_level	2.11906134
14	MP0002160_abnormal_reproductive_system	2.09019924
15	MP0000685_abnormal_immune_system	1.95195705
16	MP0002653_abnormal_ependyma_morphology	1.87132923
17	MP0003828_pulmonary_edema	1.86850311
18	MP0003880_abnormal_central_pattern	1.85917455
19	MP0005646_abnormal_pituitary_gland	1.81357880
20	MP0002822_catalepsy	1.78444678
21	MP0001968_abnormal_touch/_nociception	1.77636105
22	MP0008872_abnormal_physiological_respon	1.75150136
23	MP0003638_abnormal_response/metabolism_	1.74262375
24	MP0003011_delayed_dark_adaptation	1.73679533
25	MP0008995_early_reproductive_senescence	1.65588529
26	MP0005389_reproductive_system_phenotype	1.61491509
27	MP0002282_abnormal_trachea_morphology	1.58687356
28	MP0005084_abnormal_gallbladder_morpholo	1.49330020
29	MP0001879_abnormal_lymphatic_vessel	1.45745014
30	MP0002102_abnormal_ear_morphology	1.44775704
31	MP0002933_joint_inflammation	1.44673796
32	MP0001529_abnormal_vocalization	1.44515434
33	MP0001919_abnormal_reproductive_system	1.43439097
34	MP0000631_abnormal_neuroendocrine_gland	1.42456955
35	MP0002876_abnormal_thyroid_physiology	1.39452775
36	MP0002928_abnormal_bile_duct	1.37498924
37	MP0008007_abnormal_cellular_replicative	1.35498473
38	MP0005551_abnormal_eye_electrophysiolog	1.33513633
39	MP0002148_abnormal_hypersensitivity_rea	1.32312092
40	MP0004134_abnormal_chest_morphology	1.32245383
41	MP0001905_abnormal_dopamine_level	1.30817023
42	MP0008877_abnormal_DNA_methylation	1.29607625
43	MP0002277_abnormal_respiratory_mucosa	1.27094837
44	MP0002166_altered_tumor_susceptibility	1.26316399
45	MP0005253_abnormal_eye_physiology	1.25596910
46	MP0001835_abnormal_antigen_presentation	1.25141321
47	MP0009745_abnormal_behavioral_response	1.24799045
48	MP0000465_gastrointestinal_hemorrhage	1.18505885
49	MP0002638_abnormal_pupillary_reflex	1.16188778
50	MP0006292_abnormal_olfactory_placode	1.15310351
51	MP0005174_abnormal_tail_pigmentation	1.15031318
52	MP0002572_abnormal_emotion/affect_behav	1.11352474
53	MP0000537_abnormal_urethra_morphology	1.10419673
54	MP0001800_abnormal_humoral_immune	1.08433099
55	MP0003866_abnormal_defecation	1.06187800
56	MP0002272_abnormal_nervous_system	1.03342219
57	MP0005645_abnormal_hypothalamus_physiol	1.02512421
58	MP0003119_abnormal_digestive_system	1.01285483
59	MP0003786_premature_aging	1.00977477
60	MP0002006_tumorigenesis	1.00951216
61	MP0005171_absent_coat_pigmentation	1.00898868
62	MP0002736_abnormal_nociception_after	0.99902956
63	MP0005000_abnormal_immune_tolerance	0.99064241
64	MP0002723_abnormal_immune_serum	0.97750578
65	MP0005503_abnormal_tendon_morphology	0.97541728
66	MP0001440_abnormal_grooming_behavior	0.93026047
67	MP0003633_abnormal_nervous_system	0.91668263
68	MP0002751_abnormal_autonomic_nervous	0.90259262
69	MP0009250_abnormal_appendicular_skeleto	0.88575229
70	MP0000026_abnormal_inner_ear	0.88229344
71	MP0005448_abnormal_energy_balance	0.88023589
72	MP0005167_abnormal_blood-brain_barrier	0.84895882
73	MP0002557_abnormal_social/conspecific_i	0.84764347
74	MP0009046_muscle_twitch	0.83924197
75	MP0002249_abnormal_larynx_morphology	0.82830751
76	MP0005386_behavior/neurological_phenoty	0.82677231
77	MP0004924_abnormal_behavior	0.82677231
78	MP0000613_abnormal_salivary_gland	0.82541808
79	MP0001963_abnormal_hearing_physiology	0.81677176
80	MP0008875_abnormal_xenobiotic_pharmacok	0.81276444
81	MP0003724_increased_susceptibility_to	0.80930520
82	MP0000230_abnormal_systemic_arterial	0.80006776
83	MP0003137_abnormal_impulse_conducting	0.78432009
84	MP0005187_abnormal_penis_morphology	0.78291514
85	MP0002063_abnormal_learning/memory/cond	0.77790477
86	MP0005410_abnormal_fertilization	0.77127534
87	MP0003937_abnormal_limbs/digits/tail_de	0.76868862
88	MP0000647_abnormal_sebaceous_gland	0.75963286
89	MP0004142_abnormal_muscle_tone	0.75333641
90	MP0001485_abnormal_pinna_reflex	0.73115717
91	MP0005390_skeleton_phenotype	0.70753943
92	MP0005025_abnormal_response_to	0.70022936
93	MP0009333_abnormal_splenocyte_physiolog	0.69794539
94	MP0002420_abnormal_adaptive_immunity	0.69674832
95	MP0001486_abnormal_startle_reflex	0.69550789
96	MP0002735_abnormal_chemical_nociception	0.69082282
97	MP0006054_spinal_hemorrhage	0.68501977
98	MP0003656_abnormal_erythrocyte_physiolo	0.68378322
99	MP0005220_abnormal_exocrine_pancreas	0.66602774
100	MP0001819_abnormal_immune_cell	0.66516079

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Stomatitis (HP:0010280)	7.90971996
2	Increased IgM level (HP:0003496)	6.30211985
3	IgG deficiency (HP:0004315)	4.67129684
4	3-Methylglutaconic aciduria (HP:0003535)	3.61528189
5	Bone cyst (HP:0012062)	3.58205626
6	True hermaphroditism (HP:0010459)	3.45819829
7	Large for gestational age (HP:0001520)	3.43208642
8	Congenital stationary night blindness (HP:0007642)	3.01308586
9	Prostate neoplasm (HP:0100787)	2.97379599
10	Diaphragmatic weakness (HP:0009113)	2.95858269
11	Abnormality of T cell physiology (HP:0011840)	2.94159864
12	Abnormality of the nasal septum (HP:0000419)	2.93193057
13	Hemiplegia (HP:0002301)	2.89293704
14	Pancreatic cysts (HP:0001737)	2.88770543
15	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.79178974
16	Abnormality of alanine metabolism (HP:0010916)	2.79178974
17	Hyperalaninemia (HP:0003348)	2.79178974
18	Chorioretinal atrophy (HP:0000533)	2.69538770
19	Hemiparesis (HP:0001269)	2.65676253
20	Axonal loss (HP:0003447)	2.64183256
21	Abolished electroretinogram (ERG) (HP:0000550)	2.59086946
22	Abnormality of DNA repair (HP:0003254)	2.58887619
23	Short tibia (HP:0005736)	2.58126637
24	Pancreatic fibrosis (HP:0100732)	2.53953364
25	Acute necrotizing encephalopathy (HP:0006965)	2.50967508
26	IgA deficiency (HP:0002720)	2.47770117
27	Abnormality of the diencephalon (HP:0010662)	2.45191784
28	Congenital, generalized hypertrichosis (HP:0004540)	2.43867940
29	Prominent supraorbital ridges (HP:0000336)	2.42553392
30	Conjunctival hamartoma (HP:0100780)	2.37825565
31	Albinism (HP:0001022)	2.35571913
32	Hypergammaglobulinemia (HP:0010702)	2.33453978
33	Abnormal rod and cone electroretinograms (HP:0008323)	2.31321201
34	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.28794481
35	Abnormality of T cells (HP:0002843)	2.22542094
36	Limb dystonia (HP:0002451)	2.21917434
37	Optic disc pallor (HP:0000543)	2.21302660
38	Broad-based gait (HP:0002136)	2.17330791
39	Acute encephalopathy (HP:0006846)	2.16853973
40	Median cleft lip (HP:0000161)	2.12957657
41	Ketosis (HP:0001946)	2.12406785
42	Short hallux (HP:0010109)	2.11875100
43	Polydipsia (HP:0001959)	2.11861187
44	Abnormal drinking behavior (HP:0030082)	2.11861187
45	Hyperglycinuria (HP:0003108)	2.11853281
46	Esophageal atresia (HP:0002032)	2.11824777
47	Severe combined immunodeficiency (HP:0004430)	2.10361676
48	Nephronophthisis (HP:0000090)	2.09377341
49	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.08090529
50	Abnormal mitochondria in muscle tissue (HP:0008316)	2.06827618
51	Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)	2.05029462
52	Short 4th metacarpal (HP:0010044)	2.05029462
53	Abnormality of the incisor (HP:0000676)	2.04804308
54	Renal cortical cysts (HP:0000803)	2.03655859
55	Abnormality of midbrain morphology (HP:0002418)	2.02489001
56	Molar tooth sign on MRI (HP:0002419)	2.02489001
57	Septo-optic dysplasia (HP:0100842)	2.02051075
58	Spastic paraparesis (HP:0002313)	2.01403661
59	Abnormality of male internal genitalia (HP:0000022)	2.00754162
60	Progressive macrocephaly (HP:0004481)	2.00044064
61	Cerebral edema (HP:0002181)	1.95539843
62	Attenuation of retinal blood vessels (HP:0007843)	1.94451449
63	Absent thumb (HP:0009777)	1.93634778
64	Hemivertebrae (HP:0002937)	1.90537250
65	Meningioma (HP:0002858)	1.89585327
66	Aplasia/Hypoplasia of the hallux (HP:0008362)	1.89140961
67	Scotoma (HP:0000575)	1.88668013
68	Type II lissencephaly (HP:0007260)	1.87661644
69	Abnormality of the renal cortex (HP:0011035)	1.87489804
70	Elevated erythrocyte sedimentation rate (HP:0003565)	1.86821211
71	Mitochondrial inheritance (HP:0001427)	1.85792057
72	Male pseudohermaphroditism (HP:0000037)	1.84200420
73	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.82839787
74	Ketoacidosis (HP:0001993)	1.81269168
75	Abnormality of the renal collecting system (HP:0004742)	1.80523365
76	Neuroendocrine neoplasm (HP:0100634)	1.76903309
77	Basal cell carcinoma (HP:0002671)	1.75245053
78	Midline defect of the nose (HP:0004122)	1.73696393
79	Metaphyseal dysplasia (HP:0100255)	1.73424635
80	Hypoplastic iliac wings (HP:0002866)	1.73321351
81	Absent septum pellucidum (HP:0001331)	1.72566570
82	Sclerocornea (HP:0000647)	1.72543582
83	Pachygyria (HP:0001302)	1.72063907
84	Aplasia/Hypoplasia of the fibula (HP:0006492)	1.71864911
85	Abnormal number of incisors (HP:0011064)	1.70262988
86	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.70200391
87	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	1.69870365
88	Duplicated collecting system (HP:0000081)	1.69507363
89	Abnormality of incisor morphology (HP:0011063)	1.69014912
90	Gastrointestinal atresia (HP:0002589)	1.66335769
91	Furrowed tongue (HP:0000221)	1.65096828
92	Optic nerve hypoplasia (HP:0000609)	1.63356525
93	Supernumerary bones of the axial skeleton (HP:0009144)	1.61200612
94	Asplenia (HP:0001746)	1.60401117
95	Bilateral microphthalmos (HP:0007633)	1.60195381
96	Tinnitus (HP:0000360)	1.58833838
97	Short phalanx of the thumb (HP:0009660)	1.57487178
98	Neutropenia (HP:0001875)	1.57468214
99	Recurrent corneal erosions (HP:0000495)	1.57423638
100	Abnormality of the renal medulla (HP:0100957)	1.57379633

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	EPHA3	5.28329271
2	TSSK6	5.16363675
3	MAPKAPK5	4.49114720
4	BCKDK	4.18162399
5	PNCK	3.48057329
6	MAPK15	3.25662830
7	WNK4	2.85998957
8	EPHB1	2.40340297
9	STK39	2.24776553
10	INSRR	1.98479608
11	CAMKK2	1.95362488
12	LIMK1	1.91901884
13	TESK2	1.86804412
14	KDR	1.82524000
15	TAOK3	1.69444004
16	PINK1	1.68884677
17	PASK	1.66318369
18	TLK1	1.56587891
19	GRK6	1.44749931
20	VRK1	1.43810245
21	MAP2K2	1.43327982
22	WEE1	1.40952402
23	TESK1	1.38280507
24	CAMKK1	1.36963364
25	OXSR1	1.28754154
26	GRK1	1.26241417
27	ADRBK2	1.18310156
28	IKBKB	1.17946539
29	ITK	1.13873059
30	IKBKE	1.07856692
31	NUAK1	1.06367350
32	RPS6KA5	0.97230785
33	IRAK1	0.92104930
34	NLK	0.91352935
35	CCNB1	0.89002665
36	FRK	0.86374748
37	FER	0.84927891
38	STK16	0.83806932
39	AKT3	0.80004705
40	RPS6KA6	0.78772419
41	WNK3	0.77366468
42	MAPKAPK3	0.75490906
43	VRK2	0.72630942
44	PTK2B	0.68607283
45	PHKG1	0.67994196
46	PHKG2	0.67994196
47	TBK1	0.65847046
48	NTRK2	0.65444468
49	PIM1	0.62221267
50	DYRK2	0.60628386
51	RPS6KL1	0.60037096
52	RPS6KC1	0.60037096
53	TEC	0.59143396
54	PAK6	0.58888246
55	RPS6KA2	0.58647148
56	ZAP70	0.58229904
57	TAOK2	0.58154679
58	CAMK1D	0.57023776
59	BMPR1B	0.55453478
60	EPHA4	0.55236609
61	RPS6KA4	0.53978699
62	JAK1	0.51770081
63	TXK	0.51336189
64	ABL2	0.48947731
65	BTK	0.47666203
66	PAK3	0.47514880
67	TIE1	0.46791239
68	DAPK2	0.46360423
69	TNIK	0.46043445
70	MAP3K4	0.45888905
71	NME2	0.44189679
72	WNK1	0.43748387
73	MARK1	0.42484280
74	CASK	0.41943388
75	ADRBK1	0.39651608
76	DYRK3	0.39144343
77	CSNK1G3	0.38215504
78	MAP2K7	0.38047260
79	HIPK2	0.37848382
80	PRKCG	0.37591496
81	IGF1R	0.37547096
82	MAP3K5	0.37034401
83	ABL1	0.35928905
84	ZAK	0.35182814
85	SYK	0.34002134
86	OBSCN	0.33698408
87	MAPK7	0.32173392
88	CSNK1G2	0.31226641
89	ROCK1	0.28782995
90	PDGFRB	0.28730608
91	LCK	0.28484240
92	CSNK2A2	0.28085375
93	RPS6KA1	0.26361136
94	PRKACA	0.25037383
95	PRKCQ	0.24963226
96	SGK2	0.24170744
97	CDK3	0.23686222
98	CDK8	0.23151953
99	LYN	0.22556222
100	INSR	0.22194858

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Primary immunodeficiency_Homo sapiens_hsa05340	4.03450240
2	Maturity onset diabetes of the young_Homo sapiens_hsa04950	3.52175813
3	Oxidative phosphorylation_Homo sapiens_hsa00190	2.65844402
4	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.54108240
5	Protein export_Homo sapiens_hsa03060	2.40675092
6	Proteasome_Homo sapiens_hsa03050	2.33431101
7	Asthma_Homo sapiens_hsa05310	2.24792228
8	Allograft rejection_Homo sapiens_hsa05330	2.22791703
9	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.20806111
10	Parkinsons disease_Homo sapiens_hsa05012	2.09933945
11	Ribosome_Homo sapiens_hsa03010	2.00108988
12	Nitrogen metabolism_Homo sapiens_hsa00910	1.98540440
13	T cell receptor signaling pathway_Homo sapiens_hsa04660	1.92842363
14	Phototransduction_Homo sapiens_hsa04744	1.87507194
15	Antigen processing and presentation_Homo sapiens_hsa04612	1.87319363
16	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.87306185
17	Linoleic acid metabolism_Homo sapiens_hsa00591	1.78961288
18	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.73956188
19	Cardiac muscle contraction_Homo sapiens_hsa04260	1.71049440
20	Basal transcription factors_Homo sapiens_hsa03022	1.64513138
21	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.48840445
22	Huntingtons disease_Homo sapiens_hsa05016	1.38853284
23	RNA polymerase_Homo sapiens_hsa03020	1.37303076
24	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.36976689
25	Renin secretion_Homo sapiens_hsa04924	1.36842872
26	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	1.33752815
27	Regulation of autophagy_Homo sapiens_hsa04140	1.32853771
28	Legionellosis_Homo sapiens_hsa05134	1.32174497
29	Sulfur relay system_Homo sapiens_hsa04122	1.30722765
30	Alzheimers disease_Homo sapiens_hsa05010	1.29101115
31	Viral myocarditis_Homo sapiens_hsa05416	1.26824919
32	Rheumatoid arthritis_Homo sapiens_hsa05323	1.24605453
33	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.22242940
34	Sulfur metabolism_Homo sapiens_hsa00920	1.18947020
35	NF-kappa B signaling pathway_Homo sapiens_hsa04064	1.13962624
36	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.12700161
37	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.11042304
38	Caffeine metabolism_Homo sapiens_hsa00232	1.10452920
39	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	1.09573126
40	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	1.07462990
41	Spliceosome_Homo sapiens_hsa03040	1.06382342
42	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.04261892
43	Mismatch repair_Homo sapiens_hsa03430	1.02382369
44	Selenocompound metabolism_Homo sapiens_hsa00450	1.01351623
45	Amphetamine addiction_Homo sapiens_hsa05031	1.00696298
46	Chemical carcinogenesis_Homo sapiens_hsa05204	0.98134208
47	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.97487618
48	Nicotine addiction_Homo sapiens_hsa05033	0.96311457
49	RNA degradation_Homo sapiens_hsa03018	0.95858709
50	Taste transduction_Homo sapiens_hsa04742	0.93459853
51	Homologous recombination_Homo sapiens_hsa03440	0.91966078
52	Insulin secretion_Homo sapiens_hsa04911	0.90056761
53	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.86728738
54	Retinol metabolism_Homo sapiens_hsa00830	0.86395267
55	Estrogen signaling pathway_Homo sapiens_hsa04915	0.83818099
56	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.83157779
57	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.82133947
58	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.81200512
59	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.79520684
60	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.78836023
61	Graft-versus-host disease_Homo sapiens_hsa05332	0.78373843
62	Basal cell carcinoma_Homo sapiens_hsa05217	0.75075655
63	Ether lipid metabolism_Homo sapiens_hsa00565	0.74806097
64	Type I diabetes mellitus_Homo sapiens_hsa04940	0.74787171
65	TNF signaling pathway_Homo sapiens_hsa04668	0.74566977
66	Circadian entrainment_Homo sapiens_hsa04713	0.73783424
67	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.73425669
68	Salivary secretion_Homo sapiens_hsa04970	0.70995707
69	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.70847541
70	cAMP signaling pathway_Homo sapiens_hsa04024	0.65333725
71	Malaria_Homo sapiens_hsa05144	0.64491210
72	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.63603008
73	Nucleotide excision repair_Homo sapiens_hsa03420	0.62621773
74	Fanconi anemia pathway_Homo sapiens_hsa03460	0.62454149
75	Fat digestion and absorption_Homo sapiens_hsa04975	0.60612634
76	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.58429742
77	Folate biosynthesis_Homo sapiens_hsa00790	0.57697503
78	Morphine addiction_Homo sapiens_hsa05032	0.52347649
79	Measles_Homo sapiens_hsa05162	0.51829873
80	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.51677530
81	Olfactory transduction_Homo sapiens_hsa04740	0.50095161
82	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.48587913
83	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.48035253
84	Collecting duct acid secretion_Homo sapiens_hsa04966	0.46596856
85	Axon guidance_Homo sapiens_hsa04360	0.45972906
86	Butanoate metabolism_Homo sapiens_hsa00650	0.44610423
87	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.43913637
88	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.43495159
89	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.43120093
90	Calcium signaling pathway_Homo sapiens_hsa04020	0.40235731
91	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.38890510
92	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.38240257
93	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.38212390
94	Purine metabolism_Homo sapiens_hsa00230	0.37058985
95	Shigellosis_Homo sapiens_hsa05131	0.34107375
96	Peroxisome_Homo sapiens_hsa04146	0.33853796
97	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.33852042
98	RNA transport_Homo sapiens_hsa03013	0.32356544
99	Prion diseases_Homo sapiens_hsa05020	0.32090343
100	Gastric acid secretion_Homo sapiens_hsa04971	0.31251723

DNAJB1P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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