DNAJB3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axonemal dynein complex assembly (GO:0070286)9.93755255
2epithelial cilium movement (GO:0003351)9.87137663
3motile cilium assembly (GO:0044458)9.64118318
4spermatid development (GO:0007286)9.59145454
5reproduction (GO:0000003)9.56069200
6cilium movement (GO:0003341)8.04435082
7regulation of cilium movement (GO:0003352)7.95911761
8epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.54897319
9single fertilization (GO:0007338)7.33999676
10piRNA metabolic process (GO:0034587)7.31152424
11synaptonemal complex organization (GO:0070193)7.30284219
12male meiosis (GO:0007140)7.30051267
13synaptonemal complex assembly (GO:0007130)7.13679467
14sperm capacitation (GO:0048240)7.01383441
15negative regulation of inclusion body assembly (GO:0090084)6.78768882
16spermatogenesis (GO:0007283)6.42956224
17male gamete generation (GO:0048232)6.40686482
18microtubule depolymerization (GO:0007019)6.21397829
19fertilization (GO:0009566)6.18896860
20organic cation transport (GO:0015695)6.18611403
21spermatid nucleus differentiation (GO:0007289)5.90859434
22gamete generation (GO:0007276)5.88953462
23regulation of inclusion body assembly (GO:0090083)5.73913472
24calcium ion-dependent exocytosis (GO:0017156)5.48257077
25germ cell development (GO:0007281)5.36269904
26cellular process involved in reproduction in multicellular organism (GO:0022412)5.33164478
27cell recognition (GO:0008037)5.00337742
28ventricular system development (GO:0021591)4.97784038
29chromosome organization involved in meiosis (GO:0070192)4.90312927
30male meiosis I (GO:0007141)4.85053396
31chromosome condensation (GO:0030261)4.81957389
32DNA methylation involved in gamete generation (GO:0043046)4.74526552
33sexual reproduction (GO:0019953)4.69406013
34glycerol ether metabolic process (GO:0006662)4.68401789
35regulation of microtubule-based movement (GO:0060632)4.67480399
36multicellular organismal reproductive process (GO:0048609)4.61861613
37DNA packaging (GO:0006323)4.57793081
38microtubule severing (GO:0051013)4.56694468
39single strand break repair (GO:0000012)4.55988477
40seminiferous tubule development (GO:0072520)4.48062521
41meiotic nuclear division (GO:0007126)4.47313882
42ether metabolic process (GO:0018904)4.32506339
43left/right pattern formation (GO:0060972)4.09693552
44meiosis I (GO:0007127)3.93014321
45chaperone-mediated protein complex assembly (GO:0051131)3.90983236
46multicellular organismal development (GO:0007275)3.71533929
47monoubiquitinated protein deubiquitination (GO:0035520)3.61659747
48protein K11-linked deubiquitination (GO:0035871)3.61220428
49genitalia morphogenesis (GO:0035112)3.53190962
50meiotic cell cycle (GO:0051321)3.52332656
51sequestering of actin monomers (GO:0042989)3.38838267
52protein polyglutamylation (GO:0018095)3.36063859
53protein localization to cilium (GO:0061512)3.30552272
54protein refolding (GO:0042026)3.27149624
55regulation of spindle checkpoint (GO:0090231)3.26667193
56microtubule polymerization or depolymerization (GO:0031109)3.25718431
57nucleus organization (GO:0006997)3.15741480
58carnitine transport (GO:0015879)3.11766110
59amino-acid betaine transport (GO:0015838)3.11766110
60positive regulation of macrophage activation (GO:0043032)2.98005117
61carnitine transmembrane transport (GO:1902603)2.97902883
62centriole assembly (GO:0098534)2.97347288
63glycolytic process (GO:0006096)2.93877319
64interferon-gamma secretion (GO:0072643)2.93378860
65meiotic cell cycle process (GO:1903046)2.89636977
66cilium organization (GO:0044782)2.88583325
67mitotic sister chromatid cohesion (GO:0007064)2.86080308
68polyol catabolic process (GO:0046174)2.84611873
69alditol metabolic process (GO:0019400)2.84338558
70intraciliary transport (GO:0042073)2.84095472
71axoneme assembly (GO:0035082)2.83297488
72nucleoside diphosphate phosphorylation (GO:0006165)2.82746571
73synapsis (GO:0007129)2.80744978
74microtubule-based movement (GO:0007018)2.80143931
75cilium assembly (GO:0042384)2.77208341
76centriole replication (GO:0007099)2.71422865
77cellular component assembly involved in morphogenesis (GO:0010927)2.71188502
78gene silencing by RNA (GO:0031047)2.70097303
79polyamine biosynthetic process (GO:0006596)2.68784894
80cilium morphogenesis (GO:0060271)2.66986321
81protein-DNA complex disassembly (GO:0032986)2.63166519
82nucleosome disassembly (GO:0006337)2.63166519
83chromatin silencing (GO:0006342)2.62956387
84lactate metabolic process (GO:0006089)2.62139298
85RNA localization (GO:0006403)2.59856366
86GTP biosynthetic process (GO:0006183)2.56983903
87negative regulation of organelle assembly (GO:1902116)2.49192432
88regulation of cilium assembly (GO:1902017)2.48390570
89cell wall macromolecule catabolic process (GO:0016998)14.4031500
90cell wall macromolecule metabolic process (GO:0044036)14.4031500
91fusion of sperm to egg plasma membrane (GO:0007342)13.6005692
92sperm motility (GO:0030317)13.2892868
93acrosome reaction (GO:0007340)11.7037531
94sperm-egg recognition (GO:0035036)11.5742841
95acrosome assembly (GO:0001675)11.4823780
96multicellular organism reproduction (GO:0032504)10.9511582
97binding of sperm to zona pellucida (GO:0007339)10.4851022
98cell-cell recognition (GO:0009988)10.3594600
99plasma membrane fusion (GO:0045026)10.3586601
100cilium or flagellum-dependent cell motility (GO:0001539)10.0911117

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.81463315
2EZH2_22144423_ChIP-Seq_EOC_Human3.67772880
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.32989252
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.93696672
5PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.76602854
6STAT6_21828071_ChIP-Seq_BEAS2B_Human2.58802986
7CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.42057395
8* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.40482044
9VDR_22108803_ChIP-Seq_LS180_Human2.24345317
10FLI1_27457419_Chip-Seq_LIVER_Mouse2.17385314
11GATA1_26923725_Chip-Seq_HPCs_Mouse2.13076303
12ZNF274_21170338_ChIP-Seq_K562_Hela2.01198894
13EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.01116156
14MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse10.3343286
15PCGF2_27294783_Chip-Seq_ESCs_Mouse1.84877157
16KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.82895646
17ELK4_26923725_Chip-Seq_MESODERM_Mouse1.77522064
18TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.74238492
19KAP1_22055183_ChIP-Seq_ESCs_Mouse1.68163635
20RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.65207114
21* STAT1_17558387_ChIP-Seq_HELA_Human1.65206106
22FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.64752779
23MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.63475501
24GATA3_21867929_ChIP-Seq_CD8_Mouse1.61633305
25GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.59251142
26WDR5_24793694_ChIP-Seq_LNCAP_Human1.57305260
27CBX2_27304074_Chip-Seq_ESCs_Mouse1.57083667
28* SOX2_22085726_ChIP-Seq_NPCs_Mouse1.56934550
29ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.55224423
30TAL1_26923725_Chip-Seq_HPCs_Mouse1.53766942
31KDM2B_26808549_Chip-Seq_REH_Human1.53733017
32ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.48372289
33MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.43845404
34GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.41770404
35IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.36816206
36CBP_20019798_ChIP-Seq_JUKART_Human1.36816206
37FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.35799128
38SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.35529468
39LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.35140644
40P53_21459846_ChIP-Seq_SAOS-2_Human1.31706264
41PCGF2_27294783_Chip-Seq_NPCs_Mouse1.31642349
42GATA3_21867929_ChIP-Seq_TH1_Mouse1.31542318
43TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.29231377
44REST_21632747_ChIP-Seq_MESCs_Mouse1.27101187
45PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.25283054
46FLI1_21867929_ChIP-Seq_TH2_Mouse1.24574428
47TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21426448
48* NFE2_27457419_Chip-Seq_LIVER_Mouse1.21181170
49SUZ12_27294783_Chip-Seq_NPCs_Mouse1.21128136
50CTBP2_25329375_ChIP-Seq_LNCAP_Human1.20047232
51GF1_26923725_Chip-Seq_HPCs_Mouse1.17843352
52RAD21_21589869_ChIP-Seq_MESCs_Mouse1.14700832
53RUNX1_26923725_Chip-Seq_HPCs_Mouse1.13717457
54PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.13343175
55CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.12082029
56SPI1_26923725_Chip-Seq_HPCs_Mouse1.11992307
57EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.11963340
58SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.11225109
59KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.11037908
60ZFP57_27257070_Chip-Seq_ESCs_Mouse1.10306922
61* CRX_20693478_ChIP-Seq_RETINA_Mouse1.09190815
62NANOG_18555785_Chip-Seq_ESCs_Mouse1.08376822
63SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08373744
64OCT4_18555785_Chip-Seq_ESCs_Mouse1.06265762
65CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.06037418
66EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.05864525
67YY1_22570637_ChIP-Seq_MALME-3M_Human1.05259606
68ESET_19884257_ChIP-Seq_ESCs_Mouse1.04930328
69POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.04916248
70TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04916248
71RARA_24833708_ChIP-Seq_LIVER_Mouse1.03423996
72ERG_20517297_ChIP-Seq_VCAP_Human1.02908222
73PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.02820474
74LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse1.01215654
75RXRA_24833708_ChIP-Seq_LIVER_Mouse1.00446599
76GATA1_19941827_ChIP-Seq_MEL86_Mouse1.00353262
77RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.00340772
78* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.98491476
79NFIB_24661679_ChIP-Seq_LUNG_Mouse0.98105561
80KLF4_18555785_Chip-Seq_ESCs_Mouse0.97081588
81TET1_21451524_ChIP-Seq_MESCs_Mouse0.96815567
82FLI1_21867929_ChIP-Seq_CD8_Mouse0.95932493
83* P53_22387025_ChIP-Seq_ESCs_Mouse0.95778375
84P300_18555785_Chip-Seq_ESCs_Mouse0.95624816
85* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.95313608
86SOX9_26525672_Chip-Seq_HEART_Mouse0.95273975
87* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.95246429
88* CMYC_18555785_Chip-Seq_ESCs_Mouse0.94576500
89PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.92876556
90ESRRB_18555785_Chip-Seq_ESCs_Mouse0.92591332
91MYC_27129775_Chip-Seq_CORNEA_Mouse0.91492439
92EZH2_27294783_Chip-Seq_NPCs_Mouse0.90849908
93NFYB_21822215_ChIP-Seq_K562_Human0.90034623
94JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.89976542
95SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.89148504
96TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.89063905
97GF1B_26923725_Chip-Seq_HPCs_Mouse0.88617805
98NANOG_20526341_ChIP-Seq_ESCs_Human0.88489959
99EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.88109317
100* OCT4_21477851_ChIP-Seq_ESCs_Mouse0.87572879

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.10730510
2MP0001929_abnormal_gametogenesis5.61746270
3MP0008877_abnormal_DNA_methylation4.33620775
4MP0002210_abnormal_sex_determination3.54994709
5MP0002161_abnormal_fertility/fecundity3.33156419
6MP0001145_abnormal_male_reproductive3.03079021
7MP0000653_abnormal_sex_gland2.62913581
8MP0002653_abnormal_ependyma_morphology2.60595809
9MP0005670_abnormal_white_adipose2.56611193
10MP0005410_abnormal_fertilization16.2151446
11MP0004233_abnormal_muscle_weight1.85358667
12MP0002160_abnormal_reproductive_system1.84104041
13MP0003646_muscle_fatigue1.42981423
14MP0005623_abnormal_meninges_morphology1.37713354
15MP0008058_abnormal_DNA_repair1.28154889
16MP0002282_abnormal_trachea_morphology1.19429143
17MP0001984_abnormal_olfaction1.12580317
18MP0001765_abnormal_ion_homeostasis1.06261536
19MP0002234_abnormal_pharynx_morphology0.97829322
20MP0005389_reproductive_system_phenotype0.94456674
21MP0010094_abnormal_chromosome_stability0.88826385
22MP0005647_abnormal_sex_gland0.83046701
23MP0009046_muscle_twitch0.82848131
24MP0003115_abnormal_respiratory_system0.73212468
25MP0008995_early_reproductive_senescence0.73172405
26MP0002102_abnormal_ear_morphology0.71274256
27MP0005636_abnormal_mineral_homeostasis0.66372687
28MP0003111_abnormal_nucleus_morphology0.65647310
29MP0003011_delayed_dark_adaptation0.63450103
30MP0000358_abnormal_cell_content/0.59802841
31MP0003878_abnormal_ear_physiology0.59013672
32MP0005377_hearing/vestibular/ear_phenot0.59013672
33MP0006036_abnormal_mitochondrial_physio0.53532939
34MP0001324_abnormal_eye_pigmentation0.49974064
35MP0002928_abnormal_bile_duct0.49767494
36MP0002269_muscular_atrophy0.49282158
37MP0003699_abnormal_female_reproductive0.48205356
38MP0001545_abnormal_hematopoietic_system0.47200975
39MP0005397_hematopoietic_system_phenotyp0.47200975
40MP0001293_anophthalmia0.45610374
41MP0008057_abnormal_DNA_replication0.45090453
42MP0005666_abnormal_adipose_tissue0.43726918
43MP0001764_abnormal_homeostasis0.43660288
44MP0003786_premature_aging0.43411871
45MP0008007_abnormal_cellular_replicative0.41930238
46MP0003329_amyloid_beta_deposits0.41078019
47MP0003950_abnormal_plasma_membrane0.39470315
48MP0004036_abnormal_muscle_relaxation0.39179797
49MP0004133_heterotaxia0.38523118
50MP0005551_abnormal_eye_electrophysiolog0.38260101
51MP0001730_embryonic_growth_arrest0.37283515
52MP0010307_abnormal_tumor_latency0.36511163
53MP0001119_abnormal_female_reproductive0.36247602
54MP0006035_abnormal_mitochondrial_morpho0.36177202
55MP0002736_abnormal_nociception_after0.34998317
56MP0005253_abnormal_eye_physiology0.34966012
57MP0009278_abnormal_bone_marrow0.34858337
58MP0009115_abnormal_fat_cell0.33310819
59MP0002971_abnormal_brown_adipose0.32739013
60MP0000534_abnormal_ureter_morphology0.29850727
61MP0005391_vision/eye_phenotype0.29723432
62MP0004811_abnormal_neuron_physiology0.29102992
63MP0003861_abnormal_nervous_system0.27164832
64MP0000313_abnormal_cell_death0.26780248
65MP0004019_abnormal_vitamin_homeostasis0.26553279
66MP0000569_abnormal_digit_pigmentation0.26160681
67MP0003942_abnormal_urinary_system0.25897018
68MP0003077_abnormal_cell_cycle0.25793126
69MP0002132_abnormal_respiratory_system0.24221795
70MP0003879_abnormal_hair_cell0.23959429
71MP0002084_abnormal_developmental_patter0.23513461
72MP0003633_abnormal_nervous_system0.23094866
73MP0002152_abnormal_brain_morphology0.22690708
74MP0002169_no_abnormal_phenotype0.21832113
75MP0002873_normal_phenotype0.21492041
76MP0002139_abnormal_hepatobiliary_system0.19967315
77MP0001697_abnormal_embryo_size0.19604543
78MP0001661_extended_life_span0.19167961
79MP0001849_ear_inflammation0.18783771
80MP0002092_abnormal_eye_morphology0.18725916
81MP0001672_abnormal_embryogenesis/_devel0.18723585
82MP0005380_embryogenesis_phenotype0.18723585
83MP0001968_abnormal_touch/_nociception0.17373725
84MP0003948_abnormal_gas_homeostasis0.16963931
85MP0003631_nervous_system_phenotype0.16752486
86MP0000604_amyloidosis0.15703873
87MP0004808_abnormal_hematopoietic_stem0.15571960
88MP0002080_prenatal_lethality0.15508945
89MP0004742_abnormal_vestibular_system0.15129771
90MP0005174_abnormal_tail_pigmentation0.13946114
91MP0005319_abnormal_enzyme/_coenzyme0.13904443
92MP0000001_mammalian_phenotype0.13893851
93MP0004043_abnormal_pH_regulation0.13699847
94MP0002229_neurodegeneration0.13400921
95MP0001727_abnormal_embryo_implantation0.12931003
96MP0003959_abnormal_lean_body0.12821055
97MP0003984_embryonic_growth_retardation0.12262263
98MP0005195_abnormal_posterior_eye0.11814413
99MP0002693_abnormal_pancreas_physiology0.11767205
100MP0002085_abnormal_embryonic_tissue0.11377432

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium morphology (HP:0005938)9.32981574
2Abnormal respiratory epithelium morphology (HP:0012253)9.32981574
3Abnormal respiratory motile cilium physiology (HP:0012261)9.29316124
4Rhinitis (HP:0012384)7.67014019
5Chronic bronchitis (HP:0004469)7.44423878
6Abnormal ciliary motility (HP:0012262)7.35314248
7Infertility (HP:0000789)6.61762774
8Nasal polyposis (HP:0100582)6.46211488
9Abnormality of the nasal mucosa (HP:0000433)5.29764403
10Bronchitis (HP:0012387)4.55273265
11Bronchiectasis (HP:0002110)4.51991884
12Male infertility (HP:0003251)4.22018946
13Nephronophthisis (HP:0000090)4.21642132
14Abnormal spermatogenesis (HP:0008669)3.56071645
15Recurrent sinusitis (HP:0011108)3.27869285
16Recurrent otitis media (HP:0000403)3.26679816
17Abnormality of the renal medulla (HP:0100957)3.16773876
18Medial flaring of the eyebrow (HP:0010747)2.92307953
19Tubulointerstitial nephritis (HP:0001970)2.82532862
20Molar tooth sign on MRI (HP:0002419)2.68321241
21Abnormality of midbrain morphology (HP:0002418)2.68321241
22Recurrent bronchitis (HP:0002837)2.62506190
23Impulsivity (HP:0100710)2.61234007
24Tubular atrophy (HP:0000092)2.55402031
25Azoospermia (HP:0000027)2.54151883
26Gonadotropin excess (HP:0000837)2.39843774
27Tubulointerstitial abnormality (HP:0001969)2.34224213
28Abnormal gallbladder physiology (HP:0012438)2.18191934
29Cholecystitis (HP:0001082)2.18191934
30Dynein arm defect of respiratory motile cilia (HP:0012255)13.2073391
31Absent/shortened dynein arms (HP:0200106)13.2073391
32Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.1324620
33Postaxial foot polydactyly (HP:0001830)1.86395606
34Gait imbalance (HP:0002141)1.85414009
35Congenital primary aphakia (HP:0007707)1.85281302
36Tubulointerstitial fibrosis (HP:0005576)1.82042509
37Dyschromatopsia (HP:0007641)1.80810135
38Spastic tetraparesis (HP:0001285)1.80582781
39Stage 5 chronic kidney disease (HP:0003774)1.79535272
40Hypoplasia of the capital femoral epiphysis (HP:0003090)1.77220486
41Chronic sinusitis (HP:0011109)1.74572591
42Heterotopia (HP:0002282)1.74257896
43Congenital hepatic fibrosis (HP:0002612)1.72162022
44Abnormality of the lower motor neuron (HP:0002366)1.70831638
45Polydipsia (HP:0001959)1.67721460
46Abnormal drinking behavior (HP:0030082)1.67721460
47Aplasia/Hypoplasia of the lens (HP:0008063)1.67679337
48Decreased central vision (HP:0007663)1.63415636
49Abnormality of the renal cortex (HP:0011035)1.62463515
50Choroideremia (HP:0001139)1.58968572
51Nephrogenic diabetes insipidus (HP:0009806)1.58289824
52Abnormality of renal excretion (HP:0011036)1.58163390
53Postaxial hand polydactyly (HP:0001162)1.57374907
54Oculomotor apraxia (HP:0000657)1.57020864
55Short ribs (HP:0000773)1.54407704
56Abnormality of the dental root (HP:0006486)1.52224865
57Taurodontia (HP:0000679)1.52224865
58Abnormality of permanent molar morphology (HP:0011071)1.52224865
59Bile duct proliferation (HP:0001408)1.51722543
60Abnormal biliary tract physiology (HP:0012439)1.51722543
61Asymmetric septal hypertrophy (HP:0001670)1.49704575
62Renal dysplasia (HP:0000110)1.49648608
63Fibular hypoplasia (HP:0003038)1.49211497
64Cerebellar dysplasia (HP:0007033)1.45135879
65Facial cleft (HP:0002006)1.45076388
66Bell-shaped thorax (HP:0001591)1.43265551
67Abnormality of the dental pulp (HP:0006479)1.40191600
68Abnormality of molar morphology (HP:0011070)1.39981307
69Abnormality of molar (HP:0011077)1.39981307
70Double outlet right ventricle (HP:0001719)1.39843974
71Congenital malformation of the right heart (HP:0011723)1.39843974
72Abnormality of dentin (HP:0010299)1.39527211
73Amyotrophic lateral sclerosis (HP:0007354)1.39359529
74Vaginal atresia (HP:0000148)1.39230897
75Poor coordination (HP:0002370)1.38957158
76Bundle branch block (HP:0011710)1.37779158
77Absent epiphyses (HP:0010577)1.37677084
78Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.37677084
79Easy fatigability (HP:0003388)1.37458348
80Supernumerary spleens (HP:0009799)1.36400495
81Genital tract atresia (HP:0001827)1.36230590
82Abnormality of saccadic eye movements (HP:0000570)1.35032729
83Hemorrhage of the eye (HP:0011885)1.34005006
84Cystic liver disease (HP:0006706)1.33614225
85Abnormality of ocular smooth pursuit (HP:0000617)1.32335196
86Pancreatic fibrosis (HP:0100732)1.31449061
87Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.30358589
88Fatigable weakness (HP:0003473)1.29517777
89Abnormality of the neuromuscular junction (HP:0003398)1.29517777
90Microglossia (HP:0000171)1.26484662
91Aplasia/Hypoplasia of the tongue (HP:0010295)1.25376394
92Abnormal urine output (HP:0012590)1.25058977
93Impaired proprioception (HP:0010831)1.23570154
94Decreased electroretinogram (ERG) amplitude (HP:0000654)1.21225464
95Constricted visual fields (HP:0001133)1.21040108
96Neurofibrillary tangles (HP:0002185)1.19461158
97Tongue fasciculations (HP:0001308)1.18995800
98Sensory axonal neuropathy (HP:0003390)1.18201150
99True hermaphroditism (HP:0010459)1.17113859
100Nephropathy (HP:0000112)1.16689871

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK38.76040320
2PDK48.76040320
3TESK15.80911308
4PDK25.65727339
5PRKD34.40051041
6ICK3.96787443
7PTK2B2.07081581
8WNK42.00872818
9STK391.89883116
10NEK21.67656297
11STK381.60946414
12PNCK1.59534827
13DYRK1B1.36136195
14PDK11.09130418
15DYRK30.92684352
16IRAK10.92439491
17MAPK150.78023317
18CCNB10.77241873
19PASK0.75904448
20TYRO30.75040177
21WNK10.71982471
22CHEK20.68222883
23LMTK20.67065138
24TESK20.66973418
25TTK0.63207889
26STK30.61005641
27PLK40.60006410
28PDPK10.59994491
29EEF2K0.49862708
30WEE10.49630201
31IRAK20.49597386
32MAP2K60.48270850
33PINK10.45027550
34MUSK0.44017877
35CDC70.43535495
36STK38L0.43088943
37CHEK10.42991107
38RIPK40.42707871
39PAK10.36858418
40CAMK1G0.35781532
41BRSK20.35523327
42CDK120.35127613
43ATR0.31588990
44NTRK20.30826728
45ATM0.29564770
46PRKCG0.26672908
47PLK10.24403320
48MAP3K100.24312145
49PAK20.23787424
50MTOR0.23240980
51NEK60.21898497
52BRSK10.21367097
53MAPKAPK50.19139554
54PAK40.19116760
55PRKAA10.17349922
56CAMKK10.16142478
57MARK20.15659662
58PRKCZ0.13537380
59RPS6KB10.13272045
60CDK150.11674345
61BUB10.10786007
62CDK180.09432703
63YES10.08826638
64CSNK2A10.08656111
65BRAF0.08432704
66CDK11A0.08389949
67CDK60.08129736
68MARK30.07816927
69RPS6KA10.07061963
70PRKG20.06968692
71CDK140.06541702
72PRKCQ0.06236903
73PKN10.06233399
74AURKA0.06024487
75CDK20.05227673
76GSK3B0.04812886
77MAP3K50.04622150
78RIPK10.03857274
79BMPR1B0.03599116
80CDK10.03534755
81CSNK2A20.03514542
82WNK30.03431241
83STK100.03144757
84CDK40.02880234
85PIM10.01904827
86CSNK1D0.01876123
87PRKACG0.01872855
88PRKG10.01714381
89EGFR0.01027810
90CLK1-0.0365221
91PRKACB-0.0258515
92PRKCA-0.0220430
93CAMK2A-0.0207156
94ZAP70-0.0200973
95PRKCD-0.0198081
96AURKB-0.0184752
97PRKDC-0.0178798
98STK11-0.0091354
99PRKCB-0.0035274
100MAPK8-0.0016622

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.38892176
2Fatty acid biosynthesis_Homo sapiens_hsa000613.92284741
3Vitamin B6 metabolism_Homo sapiens_hsa007503.76569851
4Pyruvate metabolism_Homo sapiens_hsa006203.63550186
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.95688424
6Linoleic acid metabolism_Homo sapiens_hsa005912.87725965
7Propanoate metabolism_Homo sapiens_hsa006402.69904905
8Basal transcription factors_Homo sapiens_hsa030222.63657480
9Glucagon signaling pathway_Homo sapiens_hsa049222.55029197
10Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.42438732
11Selenocompound metabolism_Homo sapiens_hsa004502.41475560
12Carbohydrate digestion and absorption_Homo sapiens_hsa049732.20466827
13Oocyte meiosis_Homo sapiens_hsa041141.99552831
14Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.97602763
15Glycerolipid metabolism_Homo sapiens_hsa005611.91718925
16Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.89088090
17Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.87359717
18Pentose phosphate pathway_Homo sapiens_hsa000301.83326142
19Fanconi anemia pathway_Homo sapiens_hsa034601.73333403
20Glycosaminoglycan degradation_Homo sapiens_hsa005311.71601308
21Glycerophospholipid metabolism_Homo sapiens_hsa005641.67978623
22PPAR signaling pathway_Homo sapiens_hsa033201.63946170
23Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.58256990
24Dorso-ventral axis formation_Homo sapiens_hsa043201.53412478
25Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.51894899
26Fructose and mannose metabolism_Homo sapiens_hsa000511.48522763
27Fat digestion and absorption_Homo sapiens_hsa049751.44922945
28Carbon metabolism_Homo sapiens_hsa012001.41463664
29Amphetamine addiction_Homo sapiens_hsa050311.40215786
30Mineral absorption_Homo sapiens_hsa049781.39775267
31Cardiac muscle contraction_Homo sapiens_hsa042601.36692353
32Ether lipid metabolism_Homo sapiens_hsa005651.35837595
33Huntingtons disease_Homo sapiens_hsa050161.34448123
34Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.31979719
35Cysteine and methionine metabolism_Homo sapiens_hsa002701.24228991
36Glutathione metabolism_Homo sapiens_hsa004801.22098434
37Purine metabolism_Homo sapiens_hsa002301.18985844
38mRNA surveillance pathway_Homo sapiens_hsa030151.16992014
39RNA transport_Homo sapiens_hsa030131.16834912
40Antigen processing and presentation_Homo sapiens_hsa046121.13514337
41Fatty acid metabolism_Homo sapiens_hsa012121.09902847
42Fatty acid degradation_Homo sapiens_hsa000711.05195656
43Systemic lupus erythematosus_Homo sapiens_hsa053221.04967813
44Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.01760566
45Renin secretion_Homo sapiens_hsa049240.99624620
46Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.99381640
47Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.95059425
48Collecting duct acid secretion_Homo sapiens_hsa049660.88898353
49Biosynthesis of amino acids_Homo sapiens_hsa012300.83372983
50Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.81989322
51Chemical carcinogenesis_Homo sapiens_hsa052040.79685727
52Hedgehog signaling pathway_Homo sapiens_hsa043400.78089613
53Arachidonic acid metabolism_Homo sapiens_hsa005900.77664471
54Insulin secretion_Homo sapiens_hsa049110.68083674
55Estrogen signaling pathway_Homo sapiens_hsa049150.66831175
56Bile secretion_Homo sapiens_hsa049760.64799412
57Thyroid hormone synthesis_Homo sapiens_hsa049180.64602291
58Legionellosis_Homo sapiens_hsa051340.63832420
59Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.61189650
60Adipocytokine signaling pathway_Homo sapiens_hsa049200.60758180
61ABC transporters_Homo sapiens_hsa020100.60147863
62Renin-angiotensin system_Homo sapiens_hsa046140.59622916
63Central carbon metabolism in cancer_Homo sapiens_hsa052300.58717593
64Long-term potentiation_Homo sapiens_hsa047200.58617864
65cGMP-PKG signaling pathway_Homo sapiens_hsa040220.56236846
66Pyrimidine metabolism_Homo sapiens_hsa002400.54265522
67Inositol phosphate metabolism_Homo sapiens_hsa005620.53142518
68Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.52962228
69Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.50927806
70Alcoholism_Homo sapiens_hsa050340.49797003
71Calcium signaling pathway_Homo sapiens_hsa040200.47731601
72Protein digestion and absorption_Homo sapiens_hsa049740.47354512
73Metabolic pathways_Homo sapiens_hsa011000.46090746
74Synaptic vesicle cycle_Homo sapiens_hsa047210.44335178
75Phosphatidylinositol signaling system_Homo sapiens_hsa040700.44101603
76Pancreatic secretion_Homo sapiens_hsa049720.43283472
77Endocytosis_Homo sapiens_hsa041440.42120156
78AMPK signaling pathway_Homo sapiens_hsa041520.41987905
79Thyroid hormone signaling pathway_Homo sapiens_hsa049190.38710799
80N-Glycan biosynthesis_Homo sapiens_hsa005100.38402136
81Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.35315802
82Pentose and glucuronate interconversions_Homo sapiens_hsa000400.35116280
83DNA replication_Homo sapiens_hsa030300.34853332
84Sulfur metabolism_Homo sapiens_hsa009200.32760471
85Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.32232466
86Cell cycle_Homo sapiens_hsa041100.32127775
87Salivary secretion_Homo sapiens_hsa049700.31869362
88Gastric acid secretion_Homo sapiens_hsa049710.28351111
89Vascular smooth muscle contraction_Homo sapiens_hsa042700.28245974
90Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.26360213
91Homologous recombination_Homo sapiens_hsa034400.25711381
92Taste transduction_Homo sapiens_hsa047420.25657542
93VEGF signaling pathway_Homo sapiens_hsa043700.25141590
94cAMP signaling pathway_Homo sapiens_hsa040240.23204482
95Circadian entrainment_Homo sapiens_hsa047130.21705747
96Viral carcinogenesis_Homo sapiens_hsa052030.20136836
97Retinol metabolism_Homo sapiens_hsa008300.11677659
98RNA degradation_Homo sapiens_hsa030180.11509811
99Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.09905458
100Wnt signaling pathway_Homo sapiens_hsa043100.09252869

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