DNAJB5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the DNAJ heat shock protein 40 family of co-chaperone proteins. The encoded protein contains an N-terminal DNAJ domain and a C-terminal substrate binding domain but lacks the cysteine-rich domain found in other DNAJ family members. In mice, a multi-protein complex containing this protein, thioredoxin 1, and histone deacetylase 4, serves as a master negative regulator of cardiac hypertrophy. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1actin-mediated cell contraction (GO:0070252)6.08890216
2skeletal muscle contraction (GO:0003009)5.54826262
3regulation of short-term neuronal synaptic plasticity (GO:0048172)5.23084670
4synaptic vesicle maturation (GO:0016188)5.21711250
5response to inactivity (GO:0014854)5.10021917
6locomotory exploration behavior (GO:0035641)5.07575342
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.98293286
8vocalization behavior (GO:0071625)4.80873400
9postsynaptic membrane organization (GO:0001941)4.72335117
10regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.72207739
11regulation of synapse structural plasticity (GO:0051823)4.62976247
12regulation of relaxation of muscle (GO:1901077)4.57233366
13actin filament-based movement (GO:0030048)4.51483791
14synaptic vesicle docking involved in exocytosis (GO:0016081)4.47448646
15response to muscle activity (GO:0014850)4.45036584
16positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.43363521
17synaptic vesicle exocytosis (GO:0016079)4.40192834
18regulation of glutamate receptor signaling pathway (GO:1900449)4.39417366
19glutamate secretion (GO:0014047)4.27437621
20membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.26181175
21pyrimidine nucleobase catabolic process (GO:0006208)4.23313782
22positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.12061372
23response to stimulus involved in regulation of muscle adaptation (GO:0014874)4.06463111
24protein localization to synapse (GO:0035418)4.06362056
25neuronal action potential propagation (GO:0019227)4.05104110
26regulation of actin filament-based movement (GO:1903115)4.00873581
27ionotropic glutamate receptor signaling pathway (GO:0035235)3.94663855
28cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.94292718
29regulation of neuronal synaptic plasticity (GO:0048168)3.93557650
30skeletal muscle fiber development (GO:0048741)3.93297079
31layer formation in cerebral cortex (GO:0021819)3.92897601
32regulation of synaptic vesicle exocytosis (GO:2000300)3.91873287
33neuromuscular synaptic transmission (GO:0007274)3.87469389
34regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.87135721
35regulation of long-term neuronal synaptic plasticity (GO:0048169)3.79544945
36cell communication by electrical coupling (GO:0010644)3.78131854
37dendritic spine morphogenesis (GO:0060997)3.77791679
38exploration behavior (GO:0035640)3.77619098
39plasma membrane repair (GO:0001778)3.77554945
40sarcoplasmic reticulum calcium ion transport (GO:0070296)3.72490448
41muscle contraction (GO:0006936)3.67105708
42muscle fiber development (GO:0048747)3.61040837
43regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.60753456
44regulation of synaptic vesicle transport (GO:1902803)3.60435796
45creatine metabolic process (GO:0006600)3.59392588
46actomyosin structure organization (GO:0031032)3.56928372
47regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.54828414
48myotube cell development (GO:0014904)3.53883889
49regulation of dendritic spine morphogenesis (GO:0061001)3.53503560
50neurotransmitter-gated ion channel clustering (GO:0072578)3.51581082
51regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.50346619
52glutamate receptor signaling pathway (GO:0007215)3.47506831
53cardiac muscle hypertrophy (GO:0003300)3.47261649
54neurotransmitter secretion (GO:0007269)3.47144578
55regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.46304301
56activation of protein kinase A activity (GO:0034199)3.45894147
57synaptic transmission, glutamatergic (GO:0035249)3.45019462
58negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.44854572
59regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.44548028
60regulation of excitatory postsynaptic membrane potential (GO:0060079)3.44194353
61neuron cell-cell adhesion (GO:0007158)3.40802659
62long-term memory (GO:0007616)3.39974598
63sodium ion export (GO:0071436)3.38938909
64presynaptic membrane assembly (GO:0097105)3.35741603
65regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.35169951
66positive regulation of synapse maturation (GO:0090129)3.33578958
67muscle system process (GO:0003012)3.31262197
68regulation of cell communication by electrical coupling (GO:0010649)3.30586378
69striated muscle hypertrophy (GO:0014897)3.27731260
70regulation of membrane repolarization (GO:0060306)3.27503103
71cellular potassium ion homeostasis (GO:0030007)3.26637377
72membrane depolarization during action potential (GO:0086010)3.25122293
73regulation of postsynaptic membrane potential (GO:0060078)3.24857424
74regulation of calcium ion transmembrane transporter activity (GO:1901019)3.23564810
75regulation of calcium ion transmembrane transport (GO:1903169)3.23564810
76muscle cell cellular homeostasis (GO:0046716)3.20927011
77neuron-neuron synaptic transmission (GO:0007270)3.20876000
78positive regulation of membrane potential (GO:0045838)3.19330293
79neuron recognition (GO:0008038)3.19269395
80presynaptic membrane organization (GO:0097090)3.16500859
81negative regulation of potassium ion transmembrane transport (GO:1901380)3.16449730
82positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.16206367
83cardiac muscle cell development (GO:0055013)3.16048841
84cell communication involved in cardiac conduction (GO:0086065)3.15521127
85adult heart development (GO:0007512)3.14741859
86sarcomere organization (GO:0045214)3.14433622
87cardiac myofibril assembly (GO:0055003)3.13542184
88regulation of synaptic plasticity (GO:0048167)3.13531977
89regulation of dendritic spine development (GO:0060998)3.08743866
90cardiac muscle contraction (GO:0060048)3.08032628
91neuromuscular process controlling balance (GO:0050885)3.06477602
92neuronal ion channel clustering (GO:0045161)3.05866766
93axonal fasciculation (GO:0007413)3.05544736
94positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.05286729
95G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.05218345
96nucleobase catabolic process (GO:0046113)3.02816586
97detection of calcium ion (GO:0005513)3.02723506
98regulation of striated muscle contraction (GO:0006942)3.02587482
99establishment of mitochondrion localization (GO:0051654)3.02020996
100regulation of NFAT protein import into nucleus (GO:0051532)3.00492691
101potassium ion import (GO:0010107)2.99149549
102proline transport (GO:0015824)2.98618572
103synaptic transmission, cholinergic (GO:0007271)2.98504316
104cardiac cell development (GO:0055006)2.98295979
105muscle filament sliding (GO:0030049)2.98107028
106actin-myosin filament sliding (GO:0033275)2.98107028
107myofibril assembly (GO:0030239)2.95807134
108membrane depolarization (GO:0051899)2.95069868
109positive regulation of dendritic spine development (GO:0060999)2.93352051
110regulation of voltage-gated calcium channel activity (GO:1901385)2.93111406
111striated muscle cell development (GO:0055002)2.92770768
112cerebellar Purkinje cell differentiation (GO:0021702)2.91563265
113positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.91260114
114positive regulation of heat generation (GO:0031652)2.89939954
115negative regulation of protein localization to cell surface (GO:2000009)2.88758708
116dendrite morphogenesis (GO:0048813)2.87842491
117gamma-aminobutyric acid transport (GO:0015812)2.87831697
118striated muscle contraction (GO:0006941)2.86896009
119regulation of ion transmembrane transporter activity (GO:0032412)2.86659076
120regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.84750392
121synaptic vesicle endocytosis (GO:0048488)2.84671419
122regulation of skeletal muscle contraction (GO:0014819)2.84542015
123muscle hypertrophy (GO:0014896)2.84459782
124regulation of sarcomere organization (GO:0060297)2.84183765
125positive regulation of potassium ion transmembrane transport (GO:1901381)2.82959641
126auditory behavior (GO:0031223)2.80065283
127positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.80022534
128establishment of nucleus localization (GO:0040023)2.79771099
129dendritic spine organization (GO:0097061)2.79705959
130striated muscle adaptation (GO:0014888)2.79634088
131regulation of cation channel activity (GO:2001257)2.78141672
132regulation of transmembrane transporter activity (GO:0022898)2.77833350
133regulation of neurotransmitter secretion (GO:0046928)2.76799560
134cardiac muscle hypertrophy in response to stress (GO:0014898)2.76452223
135muscle hypertrophy in response to stress (GO:0003299)2.76452223
136cardiac muscle adaptation (GO:0014887)2.76452223
137positive regulation of neurotransmitter secretion (GO:0001956)2.76152171
138cell migration in hindbrain (GO:0021535)2.75032517
139axon extension (GO:0048675)2.74810881
140long-term synaptic potentiation (GO:0060291)2.73501773
141regulation of synaptic transmission, glutamatergic (GO:0051966)2.72303365
142regulation of the force of heart contraction (GO:0002026)2.70555656
143regulation of fever generation (GO:0031620)2.69391178
144muscle structure development (GO:0061061)2.67734438
145skeletal muscle tissue development (GO:0007519)2.67675278
146muscle organ development (GO:0007517)2.65526628
147respiratory system process (GO:0003016)2.63816520
148negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.63599643
149negative regulation of calcium ion transmembrane transport (GO:1903170)2.63599643
150muscle tissue morphogenesis (GO:0060415)2.62660137
151muscle cell development (GO:0055001)2.60606706
152cardiac muscle tissue morphogenesis (GO:0055008)2.60385416
153regulation of potassium ion transmembrane transporter activity (GO:1901016)2.59883686
154mitochondrion transport along microtubule (GO:0047497)2.59744737
155establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.59744737
156regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.58461674
157behavioral response to nicotine (GO:0035095)2.57888542

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.91628753
2SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.91563840
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.90432132
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.85138675
5DROSHA_22980978_ChIP-Seq_HELA_Human2.75458209
6* RARB_27405468_Chip-Seq_BRAIN_Mouse2.71968996
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.70514915
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.70514915
9GBX2_23144817_ChIP-Seq_PC3_Human2.58529015
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.51343416
11MTF2_20144788_ChIP-Seq_MESCs_Mouse2.45433907
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.44571686
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.41662288
14SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.38107233
15SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.36568613
16* REST_21632747_ChIP-Seq_MESCs_Mouse2.35804975
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.30716774
18EZH2_27294783_Chip-Seq_ESCs_Mouse2.28113104
19SUZ12_27294783_Chip-Seq_ESCs_Mouse2.25118295
20RNF2_27304074_Chip-Seq_ESCs_Mouse2.16724322
21TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.15507199
22MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.13230474
23EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.12112996
24EED_16625203_ChIP-ChIP_MESCs_Mouse2.07181249
25* REST_18959480_ChIP-ChIP_MESCs_Mouse2.01031407
26AR_21572438_ChIP-Seq_LNCaP_Human1.82490726
27IKZF1_21737484_ChIP-ChIP_HCT116_Human1.71557139
28CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.67573816
29ERG_21242973_ChIP-ChIP_JURKAT_Human1.57743534
30ZFP57_27257070_Chip-Seq_ESCs_Mouse1.52529587
31ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.51394838
32NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.48633041
33* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.44907998
34ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.44214436
35DNAJC2_21179169_ChIP-ChIP_NT2_Human1.43791011
36KDM2B_26808549_Chip-Seq_K562_Human1.40951392
37* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.38042123
38RBPJ_22232070_ChIP-Seq_NCS_Mouse1.36983991
39* RING1B_27294783_Chip-Seq_ESCs_Mouse1.36786397
40EP300_21415370_ChIP-Seq_HL-1_Mouse1.36359840
41TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.33915661
42TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32772514
43TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.31887540
44CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.31106979
45SMAD4_21799915_ChIP-Seq_A2780_Human1.30640518
46HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.29918102
47WT1_19549856_ChIP-ChIP_CCG9911_Human1.29821109
48ZNF274_21170338_ChIP-Seq_K562_Hela1.29772627
49EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.29645559
50SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.28183164
51* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.28045557
52GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27521797
53GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.26577638
54PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.26360629
55SOX2_21211035_ChIP-Seq_LN229_Gbm1.25846261
56THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.24938604
57RNF2_27304074_Chip-Seq_NSC_Mouse1.24719804
58CTBP1_25329375_ChIP-Seq_LNCAP_Human1.24246209
59CTBP2_25329375_ChIP-Seq_LNCAP_Human1.24091951
60CDX2_19796622_ChIP-Seq_MESCs_Mouse1.21616322
61RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.21397184
62IGF1R_20145208_ChIP-Seq_DFB_Human1.20120568
63AR_19668381_ChIP-Seq_PC3_Human1.19235640
64NR3C1_23031785_ChIP-Seq_PC12_Mouse1.18876311
65KDM2B_26808549_Chip-Seq_SUP-B15_Human1.17234066
66SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.15339967
67PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.15100356
68GATA1_26923725_Chip-Seq_HPCs_Mouse1.14196030
69RING1B_27294783_Chip-Seq_NPCs_Mouse1.13931162
70NFIB_24661679_ChIP-Seq_LUNG_Mouse1.13480466
71PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.12805266
72BMI1_23680149_ChIP-Seq_NPCS_Mouse1.12581781
73CTCF_27219007_Chip-Seq_Bcells_Human1.12277546
74GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.11962768
75CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.10812570
76P53_22127205_ChIP-Seq_FIBROBLAST_Human1.08544539
77SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.07855415
78TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.07831904
79LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07623329
80ESR1_20079471_ChIP-ChIP_T-47D_Human1.07583965
81TRIM28_21343339_ChIP-Seq_HEK293_Human1.06268060
82SMAD3_21741376_ChIP-Seq_EPCs_Human1.06110171
83* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.04319062
84RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.04107093
85EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.03984440
86CBX2_27304074_Chip-Seq_ESCs_Mouse1.02095356
87ISL1_27105846_Chip-Seq_CPCs_Mouse1.02068775
88* POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.02055078
89* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02055078
90SMAD3_21741376_ChIP-Seq_HESCs_Human1.01310867
91* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.01152545
92ARNT_22903824_ChIP-Seq_MCF-7_Human1.01142985
93ZNF217_24962896_ChIP-Seq_MCF-7_Human1.00531176
94AHR_22903824_ChIP-Seq_MCF-7_Human1.00368407
95TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.00093387
96SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.98935134
97VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.98721810
98RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98512535
99SMAD_19615063_ChIP-ChIP_OVARY_Human0.97942686
100SMAD4_21741376_ChIP-Seq_HESCs_Human0.97922198
101TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.97895695
102AR_25329375_ChIP-Seq_VCAP_Human0.96112162
103ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.96044794
104RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.94590099
105KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.94563674
106ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.93369818
107YAP1_20516196_ChIP-Seq_MESCs_Mouse0.93312679
108OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.92445968
109PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.92437296
110STAT3_23295773_ChIP-Seq_U87_Human0.92408915
111RXR_22108803_ChIP-Seq_LS180_Human0.90257707
112TAF15_26573619_Chip-Seq_HEK293_Human0.89825561
113* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.89476686
114* TP53_20018659_ChIP-ChIP_R1E_Mouse0.89424776
115NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.89196408
116DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.88862817
117TP53_16413492_ChIP-PET_HCT116_Human0.88447357
118TBX20_22328084_ChIP-Seq_HEART_Mouse0.87668368
119TOP2B_26459242_ChIP-Seq_MCF-7_Human0.86952227
120TET1_21490601_ChIP-Seq_MESCs_Mouse0.86583979
121KDM2B_26808549_Chip-Seq_DND41_Human0.86534569
122NR3C1_21868756_ChIP-Seq_MCF10A_Human0.86408232
123TCF4_23295773_ChIP-Seq_U87_Human0.84845540
124BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.83769867
125SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.82324086
126SMAD3_21741376_ChIP-Seq_ESCs_Human0.81237768
127OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.80751000
128SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80393290
129* P300_19829295_ChIP-Seq_ESCs_Human0.80133969
130* LXR_22292898_ChIP-Seq_THP-1_Human0.79857071

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.16594372
2MP0003880_abnormal_central_pattern3.76401489
3MP0000751_myopathy3.64203917
4MP0003635_abnormal_synaptic_transmissio3.53859066
5MP0004270_analgesia3.39189055
6MP0002837_dystrophic_cardiac_calcinosis3.29514585
7MP0003646_muscle_fatigue2.97557209
8MP0004145_abnormal_muscle_electrophysio2.85150179
9MP0002063_abnormal_learning/memory/cond2.83241134
10MP0009745_abnormal_behavioral_response2.81789879
11MP0002064_seizures2.55310456
12MP0002822_catalepsy2.54324381
13MP0005423_abnormal_somatic_nervous2.45398888
14MP0000749_muscle_degeneration2.34448291
15MP0009046_muscle_twitch2.32444958
16MP0004215_abnormal_myocardial_fiber2.32113589
17MP0002572_abnormal_emotion/affect_behav2.21672624
18MP0001486_abnormal_startle_reflex2.06427618
19MP0004036_abnormal_muscle_relaxation2.05604565
20MP0001968_abnormal_touch/_nociception2.05596553
21MP0002272_abnormal_nervous_system2.01249596
22MP0002734_abnormal_mechanical_nocicepti1.98622785
23MP0004084_abnormal_cardiac_muscle1.93654935
24MP0009780_abnormal_chondrocyte_physiolo1.84074947
25MP0001440_abnormal_grooming_behavior1.81016219
26MP0008569_lethality_at_weaning1.76212613
27MP0003137_abnormal_impulse_conducting1.75711731
28MP0004087_abnormal_muscle_fiber1.73076802
29MP0000747_muscle_weakness1.72664403
30MP0004130_abnormal_muscle_cell1.71734795
31MP0002909_abnormal_adrenal_gland1.69645439
32MP0005620_abnormal_muscle_contractility1.69028522
33MP0001501_abnormal_sleep_pattern1.66245779
34MP0002106_abnormal_muscle_physiology1.66183546
35MP0004484_altered_response_of1.56798064
36MP0002735_abnormal_chemical_nociception1.55660230
37MP0005330_cardiomyopathy1.54778914
38MP0004858_abnormal_nervous_system1.53965035
39MP0004233_abnormal_muscle_weight1.51460379
40MP0000778_abnormal_nervous_system1.50211228
41MP0003329_amyloid_beta_deposits1.49978993
42MP0004510_myositis1.49914133
43MP0004811_abnormal_neuron_physiology1.49162897
44MP0002067_abnormal_sensory_capabilities1.48978738
45MP0004085_abnormal_heartbeat1.47581005
46MP0000759_abnormal_skeletal_muscle1.46611080
47MP0002736_abnormal_nociception_after1.45117689
48MP0001970_abnormal_pain_threshold1.42654262
49MP0005386_behavior/neurological_phenoty1.41634243
50MP0004924_abnormal_behavior1.41634243
51MP0002733_abnormal_thermal_nociception1.41581923
52MP0002269_muscular_atrophy1.40631915
53MP0005369_muscle_phenotype1.40189939
54MP0000733_abnormal_muscle_development1.39700960
55MP0002972_abnormal_cardiac_muscle1.37452875
56MP0002184_abnormal_innervation1.33830208
57MP0002557_abnormal_social/conspecific_i1.28332433
58MP0008961_abnormal_basal_metabolism1.25120559
59MP0000955_abnormal_spinal_cord1.24212632
60MP0002066_abnormal_motor_capabilities/c1.21897826
61MP0000750_abnormal_muscle_regeneration1.20219183
62MP0003879_abnormal_hair_cell1.19156117
63MP0003633_abnormal_nervous_system1.18265132
64MP0005451_abnormal_body_composition1.15220205
65MP0002882_abnormal_neuron_morphology1.15008984
66MP0003221_abnormal_cardiomyocyte_apopto1.13402300
67MP0005646_abnormal_pituitary_gland1.10439550
68MP0005623_abnormal_meninges_morphology1.04072743
69MP0004885_abnormal_endolymph0.98003549
70MP0001502_abnormal_circadian_rhythm0.97231757
71MP0008775_abnormal_heart_ventricle0.96425979
72MP0002254_reproductive_system_inflammat0.95456650
73MP0005385_cardiovascular_system_phenoty0.94689608
74MP0001544_abnormal_cardiovascular_syste0.94689608
75MP0000013_abnormal_adipose_tissue0.94249915
76MP0003631_nervous_system_phenotype0.94142431
77MP0002638_abnormal_pupillary_reflex0.94095433
78MP0006138_congestive_heart_failure0.93449728
79MP0002234_abnormal_pharynx_morphology0.91322799
80MP0002653_abnormal_ependyma_morphology0.89627284
81MP0010630_abnormal_cardiac_muscle0.89320369
82MP0002152_abnormal_brain_morphology0.88817725
83MP0008874_decreased_physiological_sensi0.87960372
84MP0001984_abnormal_olfaction0.87331996
85MP0003075_altered_response_to0.87083927
86MP0006276_abnormal_autonomic_nervous0.86747739
87MP0004142_abnormal_muscle_tone0.84609127
88MP0003136_yellow_coat_color0.84212700
89MP0003787_abnormal_imprinting0.83431192
90MP0000049_abnormal_middle_ear0.78808490
91MP0002332_abnormal_exercise_endurance0.77616872
92MP0005535_abnormal_body_temperature0.77496014
93MP0003890_abnormal_embryonic-extraembry0.76547385
94MP0001905_abnormal_dopamine_level0.76263889
95MP0010030_abnormal_orbit_morphology0.75813934
96MP0001529_abnormal_vocalization0.75698764
97MP0003122_maternal_imprinting0.75490467
98MP0005266_abnormal_metabolism0.75382265
99MP0002069_abnormal_eating/drinking_beha0.75057860
100MP0005167_abnormal_blood-brain_barrier0.74772380
101MP0000604_amyloidosis0.72359885
102MP0002108_abnormal_muscle_morphology0.70580963
103MP0002752_abnormal_somatic_nervous0.69276461
104MP0005187_abnormal_penis_morphology0.67722753
105MP0005645_abnormal_hypothalamus_physiol0.66321432
106MP0002229_neurodegeneration0.65872361
107MP0003950_abnormal_plasma_membrane0.64793272
108MP0003690_abnormal_glial_cell0.63741382
109MP0003634_abnormal_glial_cell0.62945108
110MP0000920_abnormal_myelination0.62111376
111MP0005670_abnormal_white_adipose0.60992024
112MP0001485_abnormal_pinna_reflex0.60661911
113MP0000569_abnormal_digit_pigmentation0.60576744
114MP0009250_abnormal_appendicular_skeleto0.60133232
115MP0002090_abnormal_vision0.59821677
116MP0002127_abnormal_cardiovascular_syste0.58349090
117MP0004133_heterotaxia0.58052672
118MP0001299_abnormal_eye_distance/0.57156691
119MP0005595_abnormal_vascular_smooth0.56878176
120MP0003119_abnormal_digestive_system0.56029145
121MP0003632_abnormal_nervous_system0.54954893

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.74211153
2Exercise-induced myalgia (HP:0003738)5.23182209
3Myokymia (HP:0002411)5.15145813
4Sudden death (HP:0001699)4.73609971
5Muscle hypertrophy of the lower extremities (HP:0008968)4.44195434
6Calf muscle hypertrophy (HP:0008981)4.39600242
7Focal seizures (HP:0007359)4.34691487
8Exercise-induced muscle cramps (HP:0003710)4.25042870
9Visual hallucinations (HP:0002367)4.07981016
10Rimmed vacuoles (HP:0003805)3.94980632
11Abnormality of the calf musculature (HP:0001430)3.67751010
12Difficulty running (HP:0009046)3.56675217
13Bundle branch block (HP:0011710)3.54823917
14Muscle fiber splitting (HP:0003555)3.43269525
15Ulnar deviation of the wrist (HP:0003049)3.42202378
16Epileptic encephalopathy (HP:0200134)3.40188249
17Calcaneovalgus deformity (HP:0001848)3.36226395
18Hyporeflexia of lower limbs (HP:0002600)3.34175040
19Centrally nucleated skeletal muscle fibers (HP:0003687)3.30249656
20Muscle fiber inclusion bodies (HP:0100299)3.30208682
21Myotonia (HP:0002486)3.23351301
22Ventricular fibrillation (HP:0001663)3.20791663
23Atonic seizures (HP:0010819)3.19589348
24Broad-based gait (HP:0002136)3.19516993
25Frequent falls (HP:0002359)3.18541367
26Atrial fibrillation (HP:0005110)3.18111784
27EMG: myopathic abnormalities (HP:0003458)3.17930807
28Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.17653009
29Primary atrial arrhythmia (HP:0001692)3.13425854
30Distal lower limb muscle weakness (HP:0009053)3.04315094
31Deformed tarsal bones (HP:0008119)3.03442240
32Impaired vibration sensation in the lower limbs (HP:0002166)2.98839111
33Absence seizures (HP:0002121)2.98732757
34Progressive cerebellar ataxia (HP:0002073)2.97961824
35Prolonged QT interval (HP:0001657)2.97216400
36Febrile seizures (HP:0002373)2.96869412
37Supraventricular tachycardia (HP:0004755)2.95569107
38Poor eye contact (HP:0000817)2.91975169
39Syncope (HP:0001279)2.90614836
40Lower limb amyotrophy (HP:0007210)2.88850766
41Supraventricular arrhythmia (HP:0005115)2.88806244
42Generalized tonic-clonic seizures (HP:0002069)2.87411991
43Dysmetric saccades (HP:0000641)2.84489403
44Type 1 muscle fiber predominance (HP:0003803)2.83058679
45Action tremor (HP:0002345)2.78551443
46Absent phalangeal crease (HP:0006109)2.76862469
47Abnormality of the left ventricular outflow tract (HP:0011103)2.75091194
48Subaortic stenosis (HP:0001682)2.75091194
49Ankle clonus (HP:0011448)2.74398438
50Urinary bladder sphincter dysfunction (HP:0002839)2.74100922
51Dialeptic seizures (HP:0011146)2.73929628
52Rhabdomyolysis (HP:0003201)2.72025804
53Myoglobinuria (HP:0002913)2.71234762
54Impaired social interactions (HP:0000735)2.69713917
55Abnormal social behavior (HP:0012433)2.69713917
56Nemaline bodies (HP:0003798)2.69506291
57Abnormal EKG (HP:0003115)2.64835407
58Urinary urgency (HP:0000012)2.59160792
59Dysdiadochokinesis (HP:0002075)2.59029378
60Increased variability in muscle fiber diameter (HP:0003557)2.57747504
61Heart block (HP:0012722)2.55526244
62Depression (HP:0000716)2.54980602
63Mildly elevated creatine phosphokinase (HP:0008180)2.54624190
64Ventricular arrhythmia (HP:0004308)2.52990642
65Ventricular tachycardia (HP:0004756)2.50947286
66Supranuclear gaze palsy (HP:0000605)2.50302148
67Gaze-evoked nystagmus (HP:0000640)2.49558135
68Postural instability (HP:0002172)2.49541048
69Gowers sign (HP:0003391)2.47724482
70Dysmetria (HP:0001310)2.47218799
71Abnormality of the neuromuscular junction (HP:0003398)2.45334994
72Fatigable weakness (HP:0003473)2.45334994
73Distal lower limb amyotrophy (HP:0008944)2.44349081
74Areflexia of lower limbs (HP:0002522)2.43638682
75Malignant hyperthermia (HP:0002047)2.43199234
76Generalized muscle weakness (HP:0003324)2.42256724
77Difficulty climbing stairs (HP:0003551)2.42020629
78Anxiety (HP:0000739)2.39129818
79Scapular winging (HP:0003691)2.38276101
80Abnormality of skeletal muscle fiber size (HP:0012084)2.38241203
81Weak cry (HP:0001612)2.37958918
82Abnormality of the lower motor neuron (HP:0002366)2.36059897
83Genetic anticipation (HP:0003743)2.35932666
84Abnormal atrioventricular conduction (HP:0005150)2.35243109
85Shoulder girdle muscle weakness (HP:0003547)2.31447125
86Amblyopia (HP:0000646)2.29885725
87Abnormality of the foot musculature (HP:0001436)2.27747951
88Round ear (HP:0100830)2.26901954
89Fetal akinesia sequence (HP:0001989)2.25201493
90Abnormal finger flexion creases (HP:0006143)2.24922404
91Bulbar palsy (HP:0001283)2.23922350
92Hyperventilation (HP:0002883)2.23023727
93Abnormality of the musculature of the pelvis (HP:0001469)2.22866997
94Abnormality of the hip-girdle musculature (HP:0001445)2.22866997
95Rapidly progressive (HP:0003678)2.22130132
96Abnormality of the shoulder girdle musculature (HP:0001435)2.21857836
97Increased connective tissue (HP:0009025)2.20849972
98Atrioventricular block (HP:0001678)2.20338205
99Myopathic facies (HP:0002058)2.18940053
100Dilated cardiomyopathy (HP:0001644)2.16776078
101Asymmetric septal hypertrophy (HP:0001670)2.16660073
102Limb-girdle muscle weakness (HP:0003325)2.13924115
103Spinal rigidity (HP:0003306)2.12839419
104Waddling gait (HP:0002515)2.10772029
105Slender build (HP:0001533)2.10398591
106Muscle stiffness (HP:0003552)2.07712650
107Abnormal eating behavior (HP:0100738)2.07308925
108Foot dorsiflexor weakness (HP:0009027)2.06528976
109Hip contracture (HP:0003273)2.04556967
110Truncal ataxia (HP:0002078)2.03929022
111Distal arthrogryposis (HP:0005684)2.03772950
112Steppage gait (HP:0003376)2.02699058
113Muscular dystrophy (HP:0003560)2.00948184
114Cortical dysplasia (HP:0002539)1.98293358
115Stereotypic behavior (HP:0000733)1.96988476
116Termporal pattern (HP:0011008)1.96533875
117Insidious onset (HP:0003587)1.96533875
118Hemiplegia (HP:0002301)1.96288133
119Mutism (HP:0002300)1.94519119
120Pelvic girdle muscle weakness (HP:0003749)1.94384199
121Lower limb muscle weakness (HP:0007340)1.93985582
122Pheochromocytoma (HP:0002666)1.93766718
123EMG: neuropathic changes (HP:0003445)1.93505402
124Impaired vibratory sensation (HP:0002495)1.93501673
125Papilledema (HP:0001085)1.93337538
126Proximal amyotrophy (HP:0007126)1.92160045
127Spastic gait (HP:0002064)1.90104193
128Impaired smooth pursuit (HP:0007772)1.87900526
129Neck muscle weakness (HP:0000467)1.87855842
130Excessive salivation (HP:0003781)1.87823853
131Drooling (HP:0002307)1.87823853
132Limb-girdle muscle atrophy (HP:0003797)1.87589590
133Type 2 muscle fiber atrophy (HP:0003554)1.86943740
134Lipoatrophy (HP:0100578)1.84488598
135Respiratory insufficiency due to muscle weakness (HP:0002747)1.84197477
136Hemiparesis (HP:0001269)1.83403355
137Cerebral inclusion bodies (HP:0100314)1.82654736
138Achilles tendon contracture (HP:0001771)1.82480011
139Nonprogressive disorder (HP:0003680)1.82457256
140Abnormality of the calcaneus (HP:0008364)1.81324672
141Annular pancreas (HP:0001734)1.81112817
142Left ventricular hypertrophy (HP:0001712)1.80471230
143Muscle fiber atrophy (HP:0100295)1.73948871
144Limited hip movement (HP:0008800)1.63594321
145Wrist flexion contracture (HP:0001239)1.61258531
146Limb dystonia (HP:0002451)1.59951532

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.25291679
2NTRK33.68940168
3MAP3K93.37210119
4PHKG22.77642346
5PHKG12.77642346
6MARK12.66459655
7DAPK22.52134601
8PAK62.38909743
9MAP3K42.35047518
10TTN2.16300313
11KSR22.09608747
12PRKD32.07478458
13OBSCN2.05787190
14MINK12.02279461
15MAP2K41.70360564
16CAMKK11.68383120
17DMPK1.67742873
18NTRK21.59598037
19KSR11.56259305
20MAP2K71.52631519
21DDR21.44567231
22DYRK21.44441813
23LIMK11.42400860
24LMTK21.41609893
25STK381.36750261
26CDK51.36172588
27SIK21.35651376
28DAPK11.29279295
29TAOK11.27862419
30PINK11.25784714
31RIPK41.23934479
32MOS1.23587770
33MAP3K71.22425996
34PRPF4B1.22336145
35EPHB21.22239065
36EPHA31.20571167
37TYRO31.20179725
38DYRK1B1.15933484
39GRK71.15415578
40NEK11.13545127
41NTRK11.13494739
42NME11.07764756
43TRIB31.07682100
44MAP3K131.06449306
45CAMK11.06192968
46PAK31.05847377
47RIPK11.05842168
48TNIK1.05363455
49DYRK31.04801156
50PDK40.99125019
51PDK30.99125019
52UHMK10.98949692
53PLK20.98914299
54PTK2B0.98841048
55CAMK2A0.97210100
56PNCK0.96865891
57CDK190.95249139
58MUSK0.94935384
59STK110.94567228
60GRK50.94378922
61CASK0.93539022
62PIK3CG0.91456831
63PRKCG0.91026538
64FES0.89372834
65MAP3K120.88754388
66PRKCH0.87915874
67MAPK130.87114872
68LATS20.85842793
69MAPK120.85667237
70CAMK1G0.84229045
71MARK20.83036169
72CAMKK20.75580295
73CDC42BPA0.74057607
74DAPK30.73253376
75MAP3K60.72976301
76SGK10.72948798
77CAMK40.71993296
78ALK0.71584265
79RET0.70727935
80PDK10.70666760
81PDPK10.69967428
82CDK150.69759238
83RPS6KA20.69720542
84RAF10.69536653
85CAMK2B0.69357955
86CDK180.68785480
87MAP3K20.67532349
88PRKAA10.67403754
89CAMK2D0.67052232
90ARAF0.65491327
91CDK140.63517208
92ICK0.63103782
93SGK30.62544932
94MAP3K50.61646089
95MAPK40.61500332
96SGK4940.60645966
97SGK2230.60645966
98CDK11A0.59376175
99CSNK1G20.59349657
100RPS6KA30.54106720
101PKN10.53637107
102ERBB30.53409485
103PIK3CA0.53033134
104TAOK20.51319432
105MAP3K10.51269478
106PRKD10.50926575
107ROCK20.50591265
108SGK20.48990736
109ADRBK20.48789944
110ROCK10.48528241
111PKN20.48040239
112IRAK30.48027973
113PRKG10.47499261
114CAMK2G0.45732046
115MYLK0.43649945
116PIM20.43620719
117DYRK1A0.43161739
118PDGFRA0.42941461
119CAMK1D0.42058920
120BCR0.41922863
121FYN0.41114371
122RPS6KC10.40602312
123RPS6KL10.40602312
124MAP2K10.39798851
125PDK20.39730267
126PRKACA0.38938710
127WNK30.38676368
128WNK10.38381692
129RPS6KA10.38091892
130MAPK70.37913229
131RPS6KA60.37558468
132MAPK100.34163444
133ABL20.31621189
134AKT20.31485949
135EPHB10.30887797

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.81211081
2Circadian entrainment_Homo sapiens_hsa047132.50140216
3Olfactory transduction_Homo sapiens_hsa047402.44407127
4Synaptic vesicle cycle_Homo sapiens_hsa047212.42326866
5Long-term potentiation_Homo sapiens_hsa047202.41327625
6Glutamatergic synapse_Homo sapiens_hsa047242.23527018
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.21632442
8GABAergic synapse_Homo sapiens_hsa047272.21086216
9Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042612.14230063
10Amphetamine addiction_Homo sapiens_hsa050312.13798798
11Morphine addiction_Homo sapiens_hsa050322.09438886
12Cardiac muscle contraction_Homo sapiens_hsa042602.07135475
13Dilated cardiomyopathy_Homo sapiens_hsa054141.99798529
14Oxytocin signaling pathway_Homo sapiens_hsa049211.94775871
15Salivary secretion_Homo sapiens_hsa049701.92160849
16Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.90660354
17Gastric acid secretion_Homo sapiens_hsa049711.90638659
18Insulin secretion_Homo sapiens_hsa049111.84708058
19Dopaminergic synapse_Homo sapiens_hsa047281.84341295
20Aldosterone synthesis and secretion_Homo sapiens_hsa049251.81413035
21Cholinergic synapse_Homo sapiens_hsa047251.76971028
22Calcium signaling pathway_Homo sapiens_hsa040201.74297169
23Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.66741630
24Renin secretion_Homo sapiens_hsa049241.63053738
25GnRH signaling pathway_Homo sapiens_hsa049121.49070855
26Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.44868855
27Long-term depression_Homo sapiens_hsa047301.38199600
28Type II diabetes mellitus_Homo sapiens_hsa049301.34432115
29Taste transduction_Homo sapiens_hsa047421.30875549
30Cocaine addiction_Homo sapiens_hsa050301.30551011
31cGMP-PKG signaling pathway_Homo sapiens_hsa040221.30057803
32cAMP signaling pathway_Homo sapiens_hsa040241.28611540
33Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.26852868
34Gap junction_Homo sapiens_hsa045401.25816237
35Serotonergic synapse_Homo sapiens_hsa047261.23217558
36Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.21310614
37Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.16936755
38Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.16419777
39Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.14377394
40Axon guidance_Homo sapiens_hsa043601.11717917
41Glioma_Homo sapiens_hsa052141.11107071
42Vascular smooth muscle contraction_Homo sapiens_hsa042701.09866828
43Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.09362242
44Estrogen signaling pathway_Homo sapiens_hsa049151.05848965
45Phosphatidylinositol signaling system_Homo sapiens_hsa040701.04740757
46Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.00979758
47Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.98285005
48Melanogenesis_Homo sapiens_hsa049160.96550132
49ErbB signaling pathway_Homo sapiens_hsa040120.95380437
50Nitrogen metabolism_Homo sapiens_hsa009100.95116448
51Glucagon signaling pathway_Homo sapiens_hsa049220.94846269
52Arginine and proline metabolism_Homo sapiens_hsa003300.93305503
53Dorso-ventral axis formation_Homo sapiens_hsa043200.93049909
542-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.92159951
55Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.87594864
56Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.86314713
57VEGF signaling pathway_Homo sapiens_hsa043700.86126768
58Salmonella infection_Homo sapiens_hsa051320.83066448
59Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.82953627
60Phospholipase D signaling pathway_Homo sapiens_hsa040720.82798231
61MAPK signaling pathway_Homo sapiens_hsa040100.81878169
62Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.81464589
63Insulin signaling pathway_Homo sapiens_hsa049100.77417060
64Pancreatic secretion_Homo sapiens_hsa049720.75790786
65Circadian rhythm_Homo sapiens_hsa047100.74775828
66Thyroid hormone signaling pathway_Homo sapiens_hsa049190.73086466
67Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.73018253
68Collecting duct acid secretion_Homo sapiens_hsa049660.72186778
69Hippo signaling pathway_Homo sapiens_hsa043900.71067291
70Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.70577528
71Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.69727684
72mTOR signaling pathway_Homo sapiens_hsa041500.69142897
73Oocyte meiosis_Homo sapiens_hsa041140.66461618
74Neurotrophin signaling pathway_Homo sapiens_hsa047220.65825171
75Alzheimers disease_Homo sapiens_hsa050100.65731517
76Oxidative phosphorylation_Homo sapiens_hsa001900.65626758
77Choline metabolism in cancer_Homo sapiens_hsa052310.64663990
78Longevity regulating pathway - mammal_Homo sapiens_hsa042110.62981819
79Basal cell carcinoma_Homo sapiens_hsa052170.61632233
80Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.61348924
81Renal cell carcinoma_Homo sapiens_hsa052110.59726519
82Rap1 signaling pathway_Homo sapiens_hsa040150.59649148
83Hedgehog signaling pathway_Homo sapiens_hsa043400.59517546
84Adherens junction_Homo sapiens_hsa045200.56608128
85Amoebiasis_Homo sapiens_hsa051460.55681808
86Carbon metabolism_Homo sapiens_hsa012000.54486395
87Ras signaling pathway_Homo sapiens_hsa040140.53603045
88Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.53371083
89Thyroid hormone synthesis_Homo sapiens_hsa049180.52118398
90Carbohydrate digestion and absorption_Homo sapiens_hsa049730.50692635
91Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.50251131
92Tight junction_Homo sapiens_hsa045300.49779422
93Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.49654158
94Adipocytokine signaling pathway_Homo sapiens_hsa049200.48903199
95Insulin resistance_Homo sapiens_hsa049310.47003008
96AMPK signaling pathway_Homo sapiens_hsa041520.46255204
97Non-small cell lung cancer_Homo sapiens_hsa052230.44915255
98Inositol phosphate metabolism_Homo sapiens_hsa005620.44861003
99Endocytosis_Homo sapiens_hsa041440.44753402
100Sphingolipid signaling pathway_Homo sapiens_hsa040710.44477679
101Phototransduction_Homo sapiens_hsa047440.44383797
102Regulation of actin cytoskeleton_Homo sapiens_hsa048100.43910951
103Endometrial cancer_Homo sapiens_hsa052130.42473801
104Rheumatoid arthritis_Homo sapiens_hsa053230.42191196
105Bile secretion_Homo sapiens_hsa049760.41030276
106Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.40921438
107Parkinsons disease_Homo sapiens_hsa050120.40590869
108Wnt signaling pathway_Homo sapiens_hsa043100.39977763
109HIF-1 signaling pathway_Homo sapiens_hsa040660.39916923
110Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.39860471
111Central carbon metabolism in cancer_Homo sapiens_hsa052300.39386805
112Focal adhesion_Homo sapiens_hsa045100.39067774
113PPAR signaling pathway_Homo sapiens_hsa033200.37901892
114Notch signaling pathway_Homo sapiens_hsa043300.37553505
115AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.37417194
116Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.35751527
117Vibrio cholerae infection_Homo sapiens_hsa051100.35500400
118Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.35102872
119Ovarian steroidogenesis_Homo sapiens_hsa049130.34888149
120Prion diseases_Homo sapiens_hsa050200.34451427
121Platelet activation_Homo sapiens_hsa046110.34093721
122Prolactin signaling pathway_Homo sapiens_hsa049170.33974826
123FoxO signaling pathway_Homo sapiens_hsa040680.33767512
124Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.32474449
125Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.32092151

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