ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	branching involved in labyrinthine layer morphogenesis (GO:0060670)	6.79673772
2	cell proliferation in forebrain (GO:0021846)	6.13772897
3	pharyngeal system development (GO:0060037)	5.86099658
4	sulfation (GO:0051923)	5.23168518
5	epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)	4.76658410
6	prostate gland growth (GO:0060736)	4.63029458
7	negative regulation of systemic arterial blood pressure (GO:0003085)	4.56427057
8	regulation of cell proliferation involved in kidney development (GO:1901722)	4.50506128
9	positive regulation of cAMP-mediated signaling (GO:0043950)	4.46406013
10	regulation of sequestering of triglyceride (GO:0010889)	4.45100654
11	otic vesicle formation (GO:0030916)	4.35204757
12	positive regulation of cardiac muscle cell differentiation (GO:2000727)	4.31693912
13	positive regulation of fatty acid oxidation (GO:0046321)	4.18505188
14	cellular response to ATP (GO:0071318)	4.13655255
15	lung morphogenesis (GO:0060425)	4.12466749
16	regulation of glomerulus development (GO:0090192)	3.99935541
17	somite development (GO:0061053)	3.99278238
18	flavonoid metabolic process (GO:0009812)	3.93181543
19	purine ribonucleoside bisphosphate metabolic process (GO:0034035)	3.89591936
20	3-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)	3.89591936
21	anterior/posterior axis specification, embryo (GO:0008595)	3.83926541
22	behavioral response to nicotine (GO:0035095)	3.80033439
23	forebrain morphogenesis (GO:0048853)	3.73152988
24	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.70768542
25	NADH dehydrogenase complex assembly (GO:0010257)	3.70768542
26	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.70768542
27	positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)	3.67859971
28	negative regulation of Rho protein signal transduction (GO:0035024)	3.67287375
29	synapsis (GO:0007129)	3.63231785
30	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	3.52808787
31	replicative senescence (GO:0090399)	3.48618610
32	thyroid gland development (GO:0030878)	3.44623121
33	gland morphogenesis (GO:0022612)	3.43656176
34	spindle assembly involved in mitosis (GO:0090307)	3.43040244
35	negative regulation of mast cell activation (GO:0033004)	3.42168841
36	positive regulation of digestive system process (GO:0060456)	3.41870446
37	negative regulation of cardiac muscle tissue development (GO:0055026)	3.35935546
38	outer ear morphogenesis (GO:0042473)	3.32732206
39	DNA deamination (GO:0045006)	3.31783946
40	dentate gyrus development (GO:0021542)	3.29678545
41	response to caffeine (GO:0031000)	3.29287586
42	positive regulation of systemic arterial blood pressure (GO:0003084)	3.27352638
43	cell differentiation involved in embryonic placenta development (GO:0060706)	3.26159940
44	negative regulation of appetite (GO:0032099)	3.25107444
45	negative regulation of response to food (GO:0032096)	3.25107444
46	adrenergic receptor signaling pathway (GO:0071875)	3.23436362
47	positive regulation of mitochondrial fission (GO:0090141)	3.22543268
48	neuron remodeling (GO:0016322)	3.20325522
49	indolalkylamine metabolic process (GO:0006586)	3.18940535
50	white fat cell differentiation (GO:0050872)	3.16444240
51	centrosome duplication (GO:0051298)	3.16002097
52	regulation of DNA endoreduplication (GO:0032875)	3.15449076
53	regulation of female receptivity (GO:0045924)	3.13408654
54	tryptophan metabolic process (GO:0006568)	3.11014682
55	regulation of syncytium formation by plasma membrane fusion (GO:0060142)	3.10008753
56	negative regulation of macrophage derived foam cell differentiation (GO:0010745)	3.09866051
57	spinal cord development (GO:0021510)	3.09748509
58	regulation of tight junction assembly (GO:2000810)	3.07501255
59	mitochondrion morphogenesis (GO:0070584)	3.07499728
60	cellular anion homeostasis (GO:0030002)	3.07450182
61	aorta morphogenesis (GO:0035909)	3.06703928
62	forebrain neuron development (GO:0021884)	3.03335572
63	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.99914313
64	mesonephros development (GO:0001823)	2.98011193
65	ovulation cycle (GO:0042698)	2.97417326
66	positive regulation of inositol phosphate biosynthetic process (GO:0060732)	2.95526456
67	regulation of hippo signaling (GO:0035330)	2.95467366
68	regulation of secondary heart field cardioblast proliferation (GO:0003266)	2.93903554
69	regulation of cardioblast proliferation (GO:0003264)	2.93903554
70	serine family amino acid catabolic process (GO:0009071)	2.92976348
71	negative regulation of multicellular organism growth (GO:0040015)	2.92556159
72	regulation of somitogenesis (GO:0014807)	2.92137389
73	peristalsis (GO:0030432)	2.90431231
74	response to UV-C (GO:0010225)	2.88754280
75	myelination in peripheral nervous system (GO:0022011)	2.88321675
76	peripheral nervous system axon ensheathment (GO:0032292)	2.88321675
77	positive regulation of potassium ion transmembrane transport (GO:1901381)	2.87764815
78	indole-containing compound metabolic process (GO:0042430)	2.86701866
79	negative regulation of gene silencing (GO:0060969)	2.86520845
80	negative regulation of telomerase activity (GO:0051974)	2.86332027
81	lung-associated mesenchyme development (GO:0060484)	2.85767914
82	interkinetic nuclear migration (GO:0022027)	2.85092006
83	negative regulation of kidney development (GO:0090185)	2.84879774
84	positive regulation of catecholamine secretion (GO:0033605)	2.84333858
85	chromosome organization involved in meiosis (GO:0070192)	2.81581834
86	regulation of cholesterol storage (GO:0010885)	2.81007225
87	regulation of skeletal muscle contraction (GO:0014819)	2.79688029
88	cell migration involved in gastrulation (GO:0042074)	2.79255612
89	pituitary gland development (GO:0021983)	2.78997004
90	cellular response to lithium ion (GO:0071285)	2.75821774
91	piRNA metabolic process (GO:0034587)	2.75256890
92	DNA methylation involved in gamete generation (GO:0043046)	2.70729723
93	regulation of urine volume (GO:0035809)	2.69881607
94	response to lipoprotein particle (GO:0055094)	2.68570283
95	renal system development (GO:0072001)	2.66869176
96	negative regulation of astrocyte differentiation (GO:0048712)	2.66515623
97	regulation of collateral sprouting (GO:0048670)	2.66037498
98	tryptophan catabolic process (GO:0006569)	2.65612116
99	indole-containing compound catabolic process (GO:0042436)	2.65612116
100	indolalkylamine catabolic process (GO:0046218)	2.65612116

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	STAT6_21828071_ChIP-Seq_BEAS2B_Human	6.37645951
2	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	5.70813316
3	EZH2_22144423_ChIP-Seq_EOC_Human	4.89921694
4	EED_16625203_ChIP-ChIP_MESCs_Mouse	2.90128539
5	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.80437434
6	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.78738562
7	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	2.65692836
8	BMI1_23680149_ChIP-Seq_NPCS_Mouse	2.61394665
9	JARID2_20075857_ChIP-Seq_MESCs_Mouse	2.54129585
10	JARID2_20064375_ChIP-Seq_MESCs_Mouse	2.53434838
11	EZH2_27304074_Chip-Seq_ESCs_Mouse	2.48382496
12	GBX2_23144817_ChIP-Seq_PC3_Human	2.47551537
13	FUS_26573619_Chip-Seq_HEK293_Human	2.39211955
14	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.30703755
15	RNF2_18974828_ChIP-Seq_MESCs_Mouse	2.25980094
16	EZH2_18974828_ChIP-Seq_MESCs_Mouse	2.25980094
17	POU5F1_16153702_ChIP-ChIP_HESCs_Human	2.11562338
18	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	2.04481034
19	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	2.02731077
20	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.99196332
21	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.98889664
22	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.94751195
23	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.92379942
24	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.90382695
25	RNF2_27304074_Chip-Seq_NSC_Mouse	1.84676514
26	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.74731670
27	VDR_22108803_ChIP-Seq_LS180_Human	1.74331009
28	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.72579000
29	ZNF274_21170338_ChIP-Seq_K562_Hela	1.60833873
30	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.59534312
31	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.59194980
32	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.59177718
33	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.58417685
34	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.55079825
35	IRF1_19129219_ChIP-ChIP_H3396_Human	1.53158786
36	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.45670830
37	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.44264668
38	RING1B_27294783_Chip-Seq_ESCs_Mouse	1.43636309
39	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.40571531
40	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.39418335
41	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.39109054
42	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.37680168
43	IGF1R_20145208_ChIP-Seq_DFB_Human	1.35556426
44	MYC_18940864_ChIP-ChIP_HL60_Human	1.33981151
45	EWS_26573619_Chip-Seq_HEK293_Human	1.28923544
46	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	1.28339421
47	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.27571313
48	ER_23166858_ChIP-Seq_MCF-7_Human	1.27201081
49	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.26087981
50	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.25640599
51	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.25618724
52	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.22924111
53	GATA1_22025678_ChIP-Seq_K562_Human	1.21128363
54	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.18893892
55	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.16609155
56	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.15784486
57	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.14989355
58	BCAT_22108803_ChIP-Seq_LS180_Human	1.13486291
59	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.11581118
60	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.11544805
61	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.10064606
62	P300_19829295_ChIP-Seq_ESCs_Human	1.09954776
63	TP53_16413492_ChIP-PET_HCT116_Human	1.09566160
64	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.07109613
65	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.04089821
66	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.03644118
67	RXR_22108803_ChIP-Seq_LS180_Human	1.01098439
68	SMAD4_21799915_ChIP-Seq_A2780_Human	1.00774907
69	KDM2B_26808549_Chip-Seq_REH_Human	1.00464379
70	P53_22127205_ChIP-Seq_FIBROBLAST_Human	0.97860342
71	NANOG_16153702_ChIP-ChIP_HESCs_Human	0.97769529
72	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.96668336
73	GATA1_26923725_Chip-Seq_HPCs_Mouse	0.96485350
74	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	0.95794333
75	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.95377397
76	NCOR_22424771_ChIP-Seq_293T_Human	0.93271234
77	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.92997453
78	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.92406765
79	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.91495377
80	POU3F2_20337985_ChIP-ChIP_501MEL_Human	0.91494236
81	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	0.90339497
82	EP300_21415370_ChIP-Seq_HL-1_Mouse	0.90226786
83	STAT3_23295773_ChIP-Seq_U87_Human	0.89401857
84	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.89289436
85	RING1B_27294783_Chip-Seq_NPCs_Mouse	0.88433504
86	REST_21632747_ChIP-Seq_MESCs_Mouse	0.87798332
87	DROSHA_22980978_ChIP-Seq_HELA_Human	0.87796546
88	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.87667269
89	TCF4_23295773_ChIP-Seq_U87_Human	0.86136407
90	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.83959344
91	AHR_22903824_ChIP-Seq_MCF-7_Human	0.83884256
92	TP53_18474530_ChIP-ChIP_U2OS_Human	0.82448872
93	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	0.80659083
94	ARNT_22903824_ChIP-Seq_MCF-7_Human	0.79628805
95	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	0.79427037
96	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	0.78830330
97	AR_25329375_ChIP-Seq_VCAP_Human	0.78708697
98	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.78035155
99	CBP_20019798_ChIP-Seq_JUKART_Human	0.78035155
100	AR_21572438_ChIP-Seq_LNCaP_Human	0.77922994

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	4.85885813
2	MP0005670_abnormal_white_adipose	3.90777542
3	MP0002653_abnormal_ependyma_morphology	3.85644572
4	MP0000049_abnormal_middle_ear	3.79408483
5	MP0000678_abnormal_parathyroid_gland	3.70318466
6	MP0009379_abnormal_foot_pigmentation	3.56632628
7	MP0002160_abnormal_reproductive_system	3.35373790
8	MP0001485_abnormal_pinna_reflex	3.00844500
9	MP0002138_abnormal_hepatobiliary_system	2.85865567
10	MP0005646_abnormal_pituitary_gland	2.62895242
11	MP0002163_abnormal_gland_morphology	2.56060955
12	MP0002837_dystrophic_cardiac_calcinosis	2.38573327
13	MP0000013_abnormal_adipose_tissue	2.29628038
14	MP0009053_abnormal_anal_canal	2.08530462
15	MP0009384_cardiac_valve_regurgitation	1.98644556
16	MP0004130_abnormal_muscle_cell	1.96472379
17	MP0005389_reproductive_system_phenotype	1.94051031
18	MP0003646_muscle_fatigue	1.93949666
19	MP0003315_abnormal_perineum_morphology	1.91989434
20	MP0002249_abnormal_larynx_morphology	1.91224034
21	MP0009250_abnormal_appendicular_skeleto	1.85450444
22	MP0000631_abnormal_neuroendocrine_gland	1.83880776
23	MP0008872_abnormal_physiological_respon	1.76088501
24	MP0002139_abnormal_hepatobiliary_system	1.74163773
25	MP0005409_darkened_coat_color	1.70505887
26	MP0003119_abnormal_digestive_system	1.63524094
27	MP0003283_abnormal_digestive_organ	1.63338928
28	MP0005367_renal/urinary_system_phenotyp	1.63281301
29	MP0000516_abnormal_urinary_system	1.63281301
30	MP0005379_endocrine/exocrine_gland_phen	1.63269238
31	MP0003724_increased_susceptibility_to	1.58119621
32	MP0004145_abnormal_muscle_electrophysio	1.49162105
33	MP0000372_irregular_coat_pigmentation	1.48845830
34	MP0003937_abnormal_limbs/digits/tail_de	1.45646934
35	MP0004134_abnormal_chest_morphology	1.39742273
36	MP0001661_extended_life_span	1.39532688
37	MP0004885_abnormal_endolymph	1.38829079
38	MP0002234_abnormal_pharynx_morphology	1.37643805
39	MP0000613_abnormal_salivary_gland	1.32154104
40	MP0003938_abnormal_ear_development	1.31235017
41	MP0001963_abnormal_hearing_physiology	1.24449443
42	MP0004133_heterotaxia	1.23387931
43	MP0003693_abnormal_embryo_hatching	1.21480216
44	MP0009765_abnormal_xenobiotic_induced	1.20082986
45	MP0003942_abnormal_urinary_system	1.19333194
46	MP0002272_abnormal_nervous_system	1.14786519
47	MP0004215_abnormal_myocardial_fiber	1.14687877
48	MP0000681_abnormal_thyroid_gland	1.13308314
49	MP0000534_abnormal_ureter_morphology	1.11775580
50	MP0005551_abnormal_eye_electrophysiolog	1.11643625
51	MP0001440_abnormal_grooming_behavior	1.11084773
52	MP0001849_ear_inflammation	1.09901192
53	MP0003936_abnormal_reproductive_system	1.06209425
54	MP0002282_abnormal_trachea_morphology	1.05335085
55	MP0002876_abnormal_thyroid_physiology	0.97416042
56	MP0003656_abnormal_erythrocyte_physiolo	0.97356075
57	MP0000537_abnormal_urethra_morphology	0.97095428
58	MP0008789_abnormal_olfactory_epithelium	0.96168743
59	MP0002735_abnormal_chemical_nociception	0.96004340
60	MP0000163_abnormal_cartilage_morphology	0.93285723
61	MP0002116_abnormal_craniofacial_bone	0.91778647
62	MP0003638_abnormal_response/metabolism_	0.91128731
63	MP0005195_abnormal_posterior_eye	0.87838453
64	MP0009745_abnormal_behavioral_response	0.83231389
65	MP0000026_abnormal_inner_ear	0.82160158
66	MP0006072_abnormal_retinal_apoptosis	0.81976471
67	MP0002932_abnormal_joint_morphology	0.81909637
68	MP0008877_abnormal_DNA_methylation	0.80048387
69	MP0002971_abnormal_brown_adipose	0.78145961
70	MP0005171_absent_coat_pigmentation	0.77186802
71	MP0002928_abnormal_bile_duct	0.74422615
72	MP0005503_abnormal_tendon_morphology	0.72066271
73	MP0004185_abnormal_adipocyte_glucose	0.71883065
74	MP0010368_abnormal_lymphatic_system	0.69743627
75	MP0003567_abnormal_fetal_cardiomyocyte	0.69593541
76	MP0004142_abnormal_muscle_tone	0.69088837
77	MP0002102_abnormal_ear_morphology	0.68458277
78	MP0004085_abnormal_heartbeat	0.67328329
79	MP0001145_abnormal_male_reproductive	0.67158872
80	MP0009046_muscle_twitch	0.64878580
81	MP0002108_abnormal_muscle_morphology	0.64867724
82	MP0001188_hyperpigmentation	0.64142115
83	MP0001486_abnormal_startle_reflex	0.61786062
84	MP0002638_abnormal_pupillary_reflex	0.61771330
85	MP0002127_abnormal_cardiovascular_syste	0.61095678
86	MP0005385_cardiovascular_system_phenoty	0.60466671
87	MP0001544_abnormal_cardiovascular_syste	0.60466671
88	MP0005084_abnormal_gallbladder_morpholo	0.59468611
89	MP0001119_abnormal_female_reproductive	0.58210312
90	MP0001502_abnormal_circadian_rhythm	0.58074269
91	MP0000230_abnormal_systemic_arterial	0.57856763
92	MP0003635_abnormal_synaptic_transmissio	0.57809116
93	MP0002064_seizures	0.57580485
94	MP0000003_abnormal_adipose_tissue	0.56671565
95	MP0001348_abnormal_lacrimal_gland	0.56406381
96	MP0002177_abnormal_outer_ear	0.55939224
97	MP0000653_abnormal_sex_gland	0.55414706
98	MP0003755_abnormal_palate_morphology	0.54041431
99	MP0002210_abnormal_sex_determination	0.53758155
100	MP0009697_abnormal_copulation	0.53412275

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)	6.85788464
2	Short 1st metacarpal (HP:0010034)	6.85788464
3	Stenosis of the external auditory canal (HP:0000402)	6.05984658
4	Abnormality of the 1st metacarpal (HP:0010009)	6.05282291
5	Short phalanx of the thumb (HP:0009660)	5.22588414
6	Abnormality of the renal collecting system (HP:0004742)	4.75651495
7	Pendular nystagmus (HP:0012043)	4.52260443
8	Carpal bone hypoplasia (HP:0001498)	4.36793730
9	Ectopic kidney (HP:0000086)	3.94199830
10	Short hallux (HP:0010109)	3.93642575
11	Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)	3.91920550
12	Fused cervical vertebrae (HP:0002949)	3.90419220
13	Genetic anticipation (HP:0003743)	3.66206983
14	Aplasia/Hypoplasia of the hallux (HP:0008362)	3.63072573
15	Morphological abnormality of the middle ear (HP:0008609)	3.50366465
16	Absent thumb (HP:0009777)	3.47499685
17	Abnormality of DNA repair (HP:0003254)	3.41499467
18	Abnormality of the nasal septum (HP:0000419)	3.36462057
19	Osteomalacia (HP:0002749)	3.20555005
20	Synostosis of carpal bones (HP:0005048)	3.18901446
21	Abnormality of the proximal phalanges of the hand (HP:0009834)	3.03801795
22	Duplicated collecting system (HP:0000081)	2.97660809
23	Abolished electroretinogram (ERG) (HP:0000550)	2.97218698
24	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	2.95016789
25	Abnormality of cochlea (HP:0000375)	2.91434880
26	Chorioretinal atrophy (HP:0000533)	2.84010738
27	Anomalous pulmonary venous return (HP:0010772)	2.81881280
28	Vertebral fusion (HP:0002948)	2.80256228
29	Progressive cerebellar ataxia (HP:0002073)	2.78164539
30	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	2.71431046
31	Increased corneal curvature (HP:0100692)	2.67382237
32	Keratoconus (HP:0000563)	2.67382237
33	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.64082866
34	Porencephaly (HP:0002132)	2.58567003
35	Abnormality of the pulmonary veins (HP:0011718)	2.57388609
36	Abnormality of the phalanges of the 5th finger (HP:0004213)	2.54368087
37	Rectal fistula (HP:0100590)	2.52940256
38	Rectovaginal fistula (HP:0000143)	2.52940256
39	Short thumb (HP:0009778)	2.42014612
40	Abnormality of the middle phalanges of the toes (HP:0010183)	2.41615885
41	Congenital stationary night blindness (HP:0007642)	2.39722645
42	Carpal synostosis (HP:0009702)	2.38454738
43	Short 4th metacarpal (HP:0010044)	2.34586170
44	Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)	2.34586170
45	Short humerus (HP:0005792)	2.32940635
46	Vitreoretinal degeneration (HP:0000655)	2.27935425
47	Symphalangism affecting the phalanges of the hand (HP:0009773)	2.23187995
48	Pancreatic fibrosis (HP:0100732)	2.16893865
49	Decreased subcutaneous fat (HP:0001002)	2.16519152
50	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.16264030
51	Abnormality of the costochondral junction (HP:0000919)	2.16169965
52	Short femoral neck (HP:0100864)	2.14355131
53	True hermaphroditism (HP:0010459)	2.14182690
54	Morphological abnormality of the inner ear (HP:0011390)	2.14054996
55	Severe visual impairment (HP:0001141)	2.13758562
56	Oral leukoplakia (HP:0002745)	2.12650914
57	Absent/shortened dynein arms (HP:0200106)	2.11478439
58	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.11478439
59	Congenital sensorineural hearing impairment (HP:0008527)	2.09910176
60	Intestinal fistula (HP:0100819)	2.07908143
61	Aplasia/Hypoplasia involving the musculature (HP:0001460)	2.07754653
62	Aplasia/hypoplasia of the humerus (HP:0006507)	2.06552332
63	Abnormal rod and cone electroretinograms (HP:0008323)	2.06075111
64	Reticulocytopenia (HP:0001896)	2.05685216
65	Down-sloping shoulders (HP:0200021)	2.05651285
66	Tachypnea (HP:0002789)	2.05255550
67	Abnormal drinking behavior (HP:0030082)	2.02728880
68	Polydipsia (HP:0001959)	2.02728880
69	Synostosis involving bones of the hand (HP:0004278)	2.01810230
70	Horseshoe kidney (HP:0000085)	1.96696332
71	Asplenia (HP:0001746)	1.96660208
72	Abnormality of the phalanges of the 2nd finger (HP:0009541)	1.96402514
73	Abnormality of the carotid arteries (HP:0005344)	1.95676540
74	Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)	1.93878300
75	Pancreatic cysts (HP:0001737)	1.93312765
76	Oligomenorrhea (HP:0000876)	1.92937342
77	Acanthocytosis (HP:0001927)	1.92758778
78	Abnormality of the 4th metacarpal (HP:0010012)	1.92563700
79	Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)	1.92452254
80	Abnormal number of erythroid precursors (HP:0012131)	1.90791184
81	Decreased central vision (HP:0007663)	1.88420972
82	Vaginal fistula (HP:0004320)	1.87798851
83	Abnormality of cells of the erythroid lineage (HP:0012130)	1.85843276
84	Renal agenesis (HP:0000104)	1.85788501
85	Lip pit (HP:0100267)	1.85243123
86	Broad ribs (HP:0000885)	1.84155884
87	Tented upper lip vermilion (HP:0010804)	1.83722330
88	Methylmalonic acidemia (HP:0002912)	1.81893951
89	Abnormality of B cell number (HP:0010975)	1.80524381
90	Abnormality of the humerus (HP:0003063)	1.80317917
91	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.79546126
92	Preauricular pit (HP:0004467)	1.78522052
93	Periauricular skin pits (HP:0100277)	1.78522052
94	Hemiplegia (HP:0002301)	1.77265016
95	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.77010491
96	Hyperuricemia (HP:0002149)	1.76750871
97	Increased purine levels (HP:0004368)	1.76750871
98	Goiter (HP:0000853)	1.76142392
99	Long nose (HP:0003189)	1.74743562
100	Abnormality of the upper arm (HP:0001454)	1.74610771

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	GRK1	4.32159726
2	BLK	4.02420448
3	BCKDK	4.02336985
4	ADRBK2	3.39737398
5	ZAK	3.05377523
6	PRKD2	2.91729181
7	FRK	2.57854911
8	TLK1	2.45529327
9	PINK1	2.38895867
10	TAOK3	1.98021909
11	GRK7	1.91545085
12	VRK1	1.88706593
13	CDK9	1.87258392
14	TIE1	1.74942810
15	TAF1	1.59523328
16	KIT	1.51772551
17	ACVR1B	1.48753481
18	MAP4K2	1.48492028
19	GRK5	1.43871303
20	AURKA	1.43647595
21	TXK	1.42149184
22	FLT3	1.27271925
23	PRKCH	1.26292422
24	RPS6KA6	1.22864582
25	CDC7	1.21964840
26	STK39	1.21545133
27	BMPR1B	1.19098707
28	INSRR	1.18955670
29	SYK	1.18447029
30	PRKD3	1.10434596
31	MUSK	1.08558713
32	RPS6KL1	1.05864464
33	RPS6KC1	1.05864464
34	NUAK1	1.05421946
35	WNK4	1.00603481
36	STK4	0.98320870
37	PRKCE	0.96549058
38	TNIK	0.89681911
39	MAP2K1	0.86962079
40	VRK2	0.86708537
41	STK16	0.85139466
42	EIF2AK3	0.82218742
43	ATR	0.80962702
44	PRKG2	0.77308068
45	EPHA3	0.76982483
46	TEC	0.76835848
47	BRSK2	0.75841288
48	ABL2	0.74074415
49	OBSCN	0.73039389
50	MAP2K7	0.71250870
51	CDK19	0.70066514
52	CAMK4	0.69403019
53	PRKACA	0.67284287
54	MAP3K4	0.67282579
55	EIF2AK2	0.64364692
56	PIM1	0.62462276
57	MAPK13	0.60713639
58	PLK2	0.60436506
59	DAPK3	0.60128340
60	RPS6KA5	0.59946431
61	PKN1	0.59807877
62	TGFBR2	0.58476662
63	OXSR1	0.56067391
64	CLK1	0.55780586
65	EPHA4	0.55721639
66	PRKCG	0.54989584
67	WNK3	0.54262180
68	STK11	0.53755898
69	MAPK4	0.53522828
70	IKBKB	0.52442556
71	NTRK2	0.50177523
72	CSNK1A1	0.49611430
73	LYN	0.48459866
74	SGK1	0.48444764
75	PRKD1	0.47785406
76	INSR	0.46889848
77	DYRK2	0.45656739
78	PRKAA1	0.45357132
79	RPS6KB1	0.43520161
80	PRKACG	0.43358790
81	NEK9	0.42390835
82	ABL1	0.42179929
83	CAMK1	0.41997238
84	MELK	0.41912878
85	CSNK1G2	0.41840462
86	SMG1	0.40831069
87	PRKCQ	0.40822753
88	NLK	0.40721511
89	ADRBK1	0.40659098
90	STK3	0.40220771
91	SGK2	0.39942972
92	CAMK2A	0.39688578
93	PRKCI	0.38267182
94	CSNK1D	0.37953774
95	ITK	0.37867470
96	PRKCD	0.37561909
97	MAP3K7	0.37486662
98	PRKCA	0.35668664
99	LCK	0.35438365
100	CSNK1G3	0.35091690

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Systemic lupus erythematosus_Homo sapiens_hsa05322	3.16970550
2	Sulfur metabolism_Homo sapiens_hsa00920	2.78024667
3	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.53881623
4	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	2.49346409
5	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.41753144
6	Renin-angiotensin system_Homo sapiens_hsa04614	2.40020726
7	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.23783875
8	Sulfur relay system_Homo sapiens_hsa04122	2.22540270
9	Nicotine addiction_Homo sapiens_hsa05033	2.12344148
10	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.04903218
11	Selenocompound metabolism_Homo sapiens_hsa00450	1.98196567
12	Chemical carcinogenesis_Homo sapiens_hsa05204	1.97095672
13	Alcoholism_Homo sapiens_hsa05034	1.86084525
14	Basal cell carcinoma_Homo sapiens_hsa05217	1.79468924
15	Phototransduction_Homo sapiens_hsa04744	1.78192239
16	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.77398612
17	Retinol metabolism_Homo sapiens_hsa00830	1.74441918
18	Homologous recombination_Homo sapiens_hsa03440	1.73582405
19	Renin secretion_Homo sapiens_hsa04924	1.55597513
20	Primary immunodeficiency_Homo sapiens_hsa05340	1.55299310
21	Ribosome_Homo sapiens_hsa03010	1.49686810
22	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	1.48359183
23	Salivary secretion_Homo sapiens_hsa04970	1.48191884
24	Morphine addiction_Homo sapiens_hsa05032	1.45183248
25	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.43694521
26	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.43628518
27	Linoleic acid metabolism_Homo sapiens_hsa00591	1.43485245
28	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.41966720
29	Tryptophan metabolism_Homo sapiens_hsa00380	1.41491719
30	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.32767835
31	Fanconi anemia pathway_Homo sapiens_hsa03460	1.28599398
32	Insulin secretion_Homo sapiens_hsa04911	1.26942380
33	Taste transduction_Homo sapiens_hsa04742	1.26697930
34	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.24312532
35	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.21932882
36	Olfactory transduction_Homo sapiens_hsa04740	1.19239475
37	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.13621430
38	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	1.12920428
39	Calcium signaling pathway_Homo sapiens_hsa04020	1.11475130
40	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.05192518
41	Circadian entrainment_Homo sapiens_hsa04713	1.04756536
42	Melanoma_Homo sapiens_hsa05218	0.99693301
43	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.96677879
44	Glycerolipid metabolism_Homo sapiens_hsa00561	0.96618159
45	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.93440642
46	One carbon pool by folate_Homo sapiens_hsa00670	0.90388801
47	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.90374878
48	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.89742508
49	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.86894201
50	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.86501636
51	Glutamatergic synapse_Homo sapiens_hsa04724	0.84360957
52	Fat digestion and absorption_Homo sapiens_hsa04975	0.82585837
53	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.80496631
54	Cardiac muscle contraction_Homo sapiens_hsa04260	0.79149468
55	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.76741303
56	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.75802827
57	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.75692929
58	cAMP signaling pathway_Homo sapiens_hsa04024	0.74712156
59	Nitrogen metabolism_Homo sapiens_hsa00910	0.74254265
60	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.73212071
61	Caffeine metabolism_Homo sapiens_hsa00232	0.73170202
62	RNA degradation_Homo sapiens_hsa03018	0.72299564
63	Gap junction_Homo sapiens_hsa04540	0.70761502
64	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.70444779
65	Alzheimers disease_Homo sapiens_hsa05010	0.69393611
66	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.66666499
67	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.65064725
68	Cholinergic synapse_Homo sapiens_hsa04725	0.63826382
69	Asthma_Homo sapiens_hsa05310	0.63814845
70	PPAR signaling pathway_Homo sapiens_hsa03320	0.60086413
71	Gastric acid secretion_Homo sapiens_hsa04971	0.58746214
72	Cocaine addiction_Homo sapiens_hsa05030	0.57058763
73	DNA replication_Homo sapiens_hsa03030	0.56769089
74	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.55433719
75	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.54410803
76	GABAergic synapse_Homo sapiens_hsa04727	0.54096160
77	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.53641088
78	Serotonergic synapse_Homo sapiens_hsa04726	0.52980079
79	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.52318597
80	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.50585348
81	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.50526960
82	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.49915833
83	Oxidative phosphorylation_Homo sapiens_hsa00190	0.48821948
84	Hippo signaling pathway_Homo sapiens_hsa04390	0.48335910
85	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.48284157
86	Basal transcription factors_Homo sapiens_hsa03022	0.48121319
87	Axon guidance_Homo sapiens_hsa04360	0.47746095
88	Wnt signaling pathway_Homo sapiens_hsa04310	0.44656684
89	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.43293985
90	Type II diabetes mellitus_Homo sapiens_hsa04930	0.43291993
91	Butanoate metabolism_Homo sapiens_hsa00650	0.43215515
92	Melanogenesis_Homo sapiens_hsa04916	0.42859581
93	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.42375503
94	Ether lipid metabolism_Homo sapiens_hsa00565	0.40631347
95	Parkinsons disease_Homo sapiens_hsa05012	0.40574362
96	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.39232154
97	African trypanosomiasis_Homo sapiens_hsa05143	0.38811303
98	Nucleotide excision repair_Homo sapiens_hsa03420	0.37214957
99	Amphetamine addiction_Homo sapiens_hsa05031	0.35592289
100	Peroxisome_Homo sapiens_hsa04146	0.34761581

DNAJB5P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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