DNAJB6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the DNAJ protein family. DNAJ family members are characterized by a highly conserved amino acid stretch called the 'J-domain' and function as one of the two major classes of molecular chaperones involved in a wide range of cellular events, such as protein folding and oligomeric protein complex assembly. This family member may also play a role in polyglutamine aggregation in specific neurons. Alternative splicing of this gene results in multiple transcript variants; however, not all variants have been fully described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1purine nucleobase biosynthetic process (GO:0009113)5.31900090
2ribosome assembly (GO:0042255)5.25661269
3mitotic metaphase plate congression (GO:0007080)5.17040993
4regulation of vitamin D biosynthetic process (GO:0060556)4.93073131
5regulation of fever generation (GO:0031620)4.77704964
6regulation of chronic inflammatory response (GO:0002676)4.73551671
7sarcoplasmic reticulum calcium ion transport (GO:0070296)4.71432205
8regulation of T-helper 1 cell differentiation (GO:0045625)4.66754003
9nucleobase biosynthetic process (GO:0046112)4.62633453
10positive regulation of heat generation (GO:0031652)4.61500327
11synapsis (GO:0007129)4.61193865
12regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.54887713
13piRNA metabolic process (GO:0034587)4.48311827
14protein refolding (GO:0042026)4.30058843
15regulation of spindle organization (GO:0090224)4.23589966
16ribosome biogenesis (GO:0042254)4.18039112
17purine nucleotide salvage (GO:0032261)4.10792200
18DNA replication checkpoint (GO:0000076)4.09151177
19synaptonemal complex assembly (GO:0007130)4.06561494
20chaperone mediated protein folding requiring cofactor (GO:0051085)3.97866439
21metaphase plate congression (GO:0051310)3.95133649
22formation of translation preinitiation complex (GO:0001731)3.94480661
23synaptonemal complex organization (GO:0070193)3.93077852
24proteasome assembly (GO:0043248)3.89420528
25anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.82382926
26regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.81280275
27regulation of podosome assembly (GO:0071801)3.77656515
28DNA methylation involved in gamete generation (GO:0043046)3.76237118
29regulation of heat generation (GO:0031650)3.75154583
30DNA synthesis involved in DNA repair (GO:0000731)3.74430130
31cellular response to nicotine (GO:0071316)3.70274510
32regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.68363085
33regulation of translational termination (GO:0006449)3.68204412
34positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.67339123
35monoubiquitinated protein deubiquitination (GO:0035520)3.64432017
36protein K6-linked ubiquitination (GO:0085020)3.64402950
37folic acid metabolic process (GO:0046655)3.64081579
38positive regulation of chromosome segregation (GO:0051984)3.63975943
39mitotic nuclear envelope disassembly (GO:0007077)3.63593150
40negative regulation of phosphoprotein phosphatase activity (GO:0032515)3.56535170
41spindle checkpoint (GO:0031577)3.55476368
42regulation of chromosome segregation (GO:0051983)3.54971716
437-methylguanosine mRNA capping (GO:0006370)3.51408052
44regulation of immunoglobulin secretion (GO:0051023)3.49619197
45negative regulation of NF-kappaB import into nucleus (GO:0042347)3.49376797
46negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.48903321
47mitotic spindle checkpoint (GO:0071174)3.47277957
48positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.46762268
49membrane disassembly (GO:0030397)3.46748413
50nuclear envelope disassembly (GO:0051081)3.46748413
51chromosome organization involved in meiosis (GO:0070192)3.46414714
52rRNA modification (GO:0000154)3.45899687
53nuclear pore organization (GO:0006999)3.44134258
54purine-containing compound salvage (GO:0043101)3.42782441
55establishment of chromosome localization (GO:0051303)3.41662192
56negative regulation of chromosome segregation (GO:0051985)3.40956946
57negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.40025239
587-methylguanosine RNA capping (GO:0009452)3.39260424
59RNA capping (GO:0036260)3.39260424
60negative regulation of mitotic sister chromatid separation (GO:2000816)3.38362845
61negative regulation of mitotic sister chromatid segregation (GO:0033048)3.38362845
62negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.38362845
63negative regulation of sister chromatid segregation (GO:0033046)3.38362845
64attachment of spindle microtubules to kinetochore (GO:0008608)3.37891287
65termination of RNA polymerase III transcription (GO:0006386)3.37015676
66transcription elongation from RNA polymerase III promoter (GO:0006385)3.37015676
67microtubule depolymerization (GO:0007019)3.36107082
68protein localization to kinetochore (GO:0034501)3.35623505
69blastocyst development (GO:0001824)3.34750293
70mitotic spindle assembly checkpoint (GO:0007094)3.34641248
71regulation of MHC class II biosynthetic process (GO:0045346)3.34077949
72vitamin transmembrane transport (GO:0035461)3.33996789
73meiosis I (GO:0007127)3.33655333
74maturation of 5.8S rRNA (GO:0000460)3.33427382
75negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.31778337
76regulation of double-strand break repair via homologous recombination (GO:0010569)3.30451808
77male meiosis (GO:0007140)3.29923956
78protein localization to chromosome, centromeric region (GO:0071459)3.29506303
79negative regulation of amino acid transport (GO:0051956)3.28665481
80transcription elongation from RNA polymerase I promoter (GO:0006362)3.26854045
81mitotic sister chromatid segregation (GO:0000070)3.26433544
82regulation of mitotic metaphase/anaphase transition (GO:0030071)3.26030481
83spindle assembly checkpoint (GO:0071173)3.25766381
84de novo protein folding (GO:0006458)3.25570971
85regulation of centrosome cycle (GO:0046605)3.25193609
86regulation of glutamate secretion (GO:0014048)3.25094738
87establishment of protein localization to mitochondrial membrane (GO:0090151)3.23551067
88negative regulation of nitric oxide biosynthetic process (GO:0045019)3.22837416
89folic acid transport (GO:0015884)3.22291459
90positive regulation of ligase activity (GO:0051351)3.21443599
91regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.21222734
92histone exchange (GO:0043486)3.20506383
93regulation of vitamin metabolic process (GO:0030656)3.19474368
94interferon-gamma secretion (GO:0072643)3.19450521
95negative regulation of interleukin-12 production (GO:0032695)3.18491849
96DNA replication-dependent nucleosome assembly (GO:0006335)3.17381687
97DNA replication-dependent nucleosome organization (GO:0034723)3.17381687
98de novo posttranslational protein folding (GO:0051084)3.16365125
99regulation of mitotic spindle organization (GO:0060236)3.15395009
100termination of RNA polymerase I transcription (GO:0006363)3.15097424
101male meiosis I (GO:0007141)3.14741877
102branching involved in labyrinthine layer morphogenesis (GO:0060670)3.13850037
103DNA replication initiation (GO:0006270)3.13265245
104negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.13141734
105negative regulation of ligase activity (GO:0051352)3.13141734
106regulation of histone H3-K9 methylation (GO:0051570)3.12426207
107regulation of ubiquitin-protein transferase activity (GO:0051438)3.10292757
108regulation of translation in response to stress (GO:0043555)3.09774083
109spliceosomal snRNP assembly (GO:0000387)3.08753273
110regulation of mitotic sister chromatid separation (GO:0010965)3.08323740
111regulation of mitotic sister chromatid segregation (GO:0033047)3.08323740
112regulation of sister chromatid segregation (GO:0033045)3.08323740
113establishment of integrated proviral latency (GO:0075713)3.07238832
114DNA replication-independent nucleosome assembly (GO:0006336)3.07037656
115DNA replication-independent nucleosome organization (GO:0034724)3.07037656
116skeletal muscle contraction (GO:0003009)3.06855423
117meiotic nuclear division (GO:0007126)3.06334537
118transcription from RNA polymerase I promoter (GO:0006360)3.05576932
119nuclear pore complex assembly (GO:0051292)3.05350050
120transcription elongation from RNA polymerase II promoter (GO:0006368)3.03942055
121protein neddylation (GO:0045116)3.02134274
122polyamine biosynthetic process (GO:0006596)3.00747403
123CENP-A containing nucleosome assembly (GO:0034080)3.00330943
124protein localization to chromosome (GO:0034502)3.00144803
125chromatin remodeling at centromere (GO:0031055)3.00078761
126regulation of meiosis I (GO:0060631)2.99684322
127DNA-templated transcription, elongation (GO:0006354)2.97438075
128positive regulation of cAMP-mediated signaling (GO:0043950)2.97122662
129ribonucleoprotein complex biogenesis (GO:0022613)2.95936464
130positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.95704777
131intestinal epithelial cell development (GO:0060576)2.95251169
132nuclear envelope organization (GO:0006998)2.94594067
133negative regulation of proteasomal protein catabolic process (GO:1901799)2.93829092
134establishment of viral latency (GO:0019043)2.93376995
135cell cycle G1/S phase transition (GO:0044843)2.90898020
136G1/S transition of mitotic cell cycle (GO:0000082)2.90898020
137regulation of ligase activity (GO:0051340)2.90516033
138DNA deamination (GO:0045006)2.90249200
139regulation of nitric oxide biosynthetic process (GO:0045428)2.89236459
140* negative regulation of inclusion body assembly (GO:0090084)2.85764039
141heart process (GO:0003015)2.84992571
142heart contraction (GO:0060047)2.84992571
143response to peptidoglycan (GO:0032494)2.82092040
144regulation of cytokine secretion involved in immune response (GO:0002739)2.81635794
145adenosine receptor signaling pathway (GO:0001973)2.79818058
146cellular response to arsenic-containing substance (GO:0071243)2.78734234
147IMP metabolic process (GO:0046040)2.77735432
148positive regulation of T-helper cell differentiation (GO:0045624)2.76909059
149natural killer cell mediated immunity (GO:0002228)2.75893567
150natural killer cell mediated cytotoxicity (GO:0042267)2.75893567
151positive regulation of nitric oxide biosynthetic process (GO:0045429)2.72442445
152kynurenine metabolic process (GO:0070189)2.72436387
153activation of MAPKKK activity (GO:0000185)2.71938058
154regulation of helicase activity (GO:0051095)2.71131311
155response to inactivity (GO:0014854)2.69930826
156regulation of chemokine biosynthetic process (GO:0045073)2.69617221
157endothelium development (GO:0003158)2.67073223
158nucleotide salvage (GO:0043173)2.63620865
159IMP biosynthetic process (GO:0006188)2.63538098
160histone H2A acetylation (GO:0043968)2.62661807
161positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.57288064
162muscle filament sliding (GO:0030049)2.56898138
163actin-myosin filament sliding (GO:0033275)2.56898138
164negative regulation of lipid storage (GO:0010888)2.55698182
165positive regulation of chemokine biosynthetic process (GO:0045080)2.54940119
166sequestering of actin monomers (GO:0042989)2.54549684
167regulation of mononuclear cell migration (GO:0071675)2.54500409
168adenosine metabolic process (GO:0046085)2.53861240
169amine catabolic process (GO:0009310)2.52348502
170cellular biogenic amine catabolic process (GO:0042402)2.52348502
171epithelial cell differentiation involved in kidney development (GO:0035850)2.52206062
172positive regulation of amino acid transport (GO:0051957)2.50724580
173negative regulation of telomere maintenance (GO:0032205)2.47939020
174regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.47527740
175regulation of NF-kappaB import into nucleus (GO:0042345)2.43574475
176regulation of amino acid transport (GO:0051955)2.42971099
177regulation of cAMP-dependent protein kinase activity (GO:2000479)2.42363248
178negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.41418521
179negative regulation of calcium ion transmembrane transport (GO:1903170)2.41418521
180cyclooxygenase pathway (GO:0019371)2.41216075
181negative regulation of cation channel activity (GO:2001258)2.40793944
182neutrophil activation involved in immune response (GO:0002283)2.37266622
183positive regulation of vasculogenesis (GO:2001214)2.37265878
184positive regulation of interleukin-6 production (GO:0032755)2.36812241
185intrinsic apoptotic signaling pathway in response to oxidative stress (GO:0008631)2.36784637
186regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.34156799
187regulation of T-helper cell differentiation (GO:0045622)2.32461490
188regulation of neuron projection regeneration (GO:0070570)2.31544098
189regulation of axon regeneration (GO:0048679)2.31544098
190regulation of T-helper 2 cell differentiation (GO:0045628)2.28707920
191response to nerve growth factor (GO:1990089)2.28216966

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human6.74947225
2E2F7_22180533_ChIP-Seq_HELA_Human5.88586785
3MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.57031781
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.55157076
5FOXM1_23109430_ChIP-Seq_U2OS_Human4.13290110
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.91688507
7KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.54723499
8KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.54723499
9KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.54723499
10* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.27186583
11ETS1_20019798_ChIP-Seq_JURKAT_Human3.24161579
12CREB1_15753290_ChIP-ChIP_HEK293T_Human3.22279281
13KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.15368902
14E2F4_17652178_ChIP-ChIP_JURKAT_Human3.12887718
15GABP_17652178_ChIP-ChIP_JURKAT_Human3.08962204
16* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.93591704
17TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.92854455
18EST1_17652178_ChIP-ChIP_JURKAT_Human2.85338239
19* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.81980744
20FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.73131623
21IRF8_21731497_ChIP-ChIP_J774_Mouse2.71935426
22* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.70709492
23* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.65666038
24VDR_23849224_ChIP-Seq_CD4+_Human2.50847707
25* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.32340417
26AR_21909140_ChIP-Seq_LNCAP_Human2.30107065
27MYCN_18555785_ChIP-Seq_MESCs_Mouse2.24032200
28CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.19676753
29* GABP_19822575_ChIP-Seq_HepG2_Human2.19452091
30* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.19354765
31PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.16307438
32XRN2_22483619_ChIP-Seq_HELA_Human2.14697337
33POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.09926402
34Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.09250620
35CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.08709316
36STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.08489236
37DCP1A_22483619_ChIP-Seq_HELA_Human2.04825223
38MYB_21317192_ChIP-Seq_ERMYB_Mouse2.02451730
39NANOG_18555785_ChIP-Seq_MESCs_Mouse2.01256551
40NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.94556228
41MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.86955411
42E2F1_18555785_ChIP-Seq_MESCs_Mouse1.84915744
43HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.82599847
44TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.80677214
45* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.79638195
46YY1_21170310_ChIP-Seq_MESCs_Mouse1.77089005
47IGF1R_20145208_ChIP-Seq_DFB_Human1.76679908
48FOXP3_21729870_ChIP-Seq_TREG_Human1.73467768
49SALL1_21062744_ChIP-ChIP_HESCs_Human1.71808055
50IRF8_27001747_Chip-Seq_BMDM_Mouse1.71742791
51TTF2_22483619_ChIP-Seq_HELA_Human1.70129183
52PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.68692127
53* E2F1_21310950_ChIP-Seq_MCF-7_Human1.68539094
54HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.67724581
55KDM5A_27292631_Chip-Seq_BREAST_Human1.67439020
56* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.65162221
57ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.56398571
58YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.56001472
59NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.55631337
60FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.55549201
61KLF4_18555785_ChIP-Seq_MESCs_Mouse1.55297021
62NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.54339420
63THAP11_20581084_ChIP-Seq_MESCs_Mouse1.54177958
64* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.53997479
65LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.53845616
66EGR1_19374776_ChIP-ChIP_THP-1_Human1.53302987
67GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.49924417
68* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.49126154
69SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.48502967
70STAT3_1855785_ChIP-Seq_MESCs_Mouse1.47804830
71SMAD_19615063_ChIP-ChIP_OVARY_Human1.45574933
72HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.43169138
73* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.42914186
74ELK1_19687146_ChIP-ChIP_HELA_Human1.38570362
75* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.38191225
76* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.38095369
77WT1_19549856_ChIP-ChIP_CCG9911_Human1.37981656
78* IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.37483140
79NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.37453773
80* CLOCK_20551151_ChIP-Seq_293T_Human1.36752531
81POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.34985560
82POU3F2_20337985_ChIP-ChIP_501MEL_Human1.34364563
83SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.30647326
84TP63_19390658_ChIP-ChIP_HaCaT_Human1.28761695
85VDR_22108803_ChIP-Seq_LS180_Human1.25976811
86NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.25537080
87ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.24715766
88KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.23242150
89PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.23157495
90* ZNF263_19887448_ChIP-Seq_K562_Human1.22437516
91SOX2_16153702_ChIP-ChIP_HESCs_Human1.22162949
92POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.19754665
93DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.19229398
94GBX2_23144817_ChIP-Seq_PC3_Human1.17779142
95POU5F1_16153702_ChIP-ChIP_HESCs_Human1.17765102
96CIITA_25753668_ChIP-Seq_RAJI_Human1.16968369
97PADI4_21655091_ChIP-ChIP_MCF-7_Human1.15707124
98DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.14053380
99NANOG_21062744_ChIP-ChIP_HESCs_Human1.12717390
100SCL_19346495_ChIP-Seq_HPC-7_Human1.12711012
101KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.12596798
102STAT4_19710469_ChIP-ChIP_TH1__Mouse1.12059757
103CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.11455880
104* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.11115050
105VDR_24787735_ChIP-Seq_THP-1_Human1.08965468
106TFEB_21752829_ChIP-Seq_HELA_Human1.08237031
107RNF2_27304074_Chip-Seq_NSC_Mouse1.08168955
108PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.08116080
109LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.07723411
110* KAP1_22055183_ChIP-Seq_ESCs_Mouse1.07434579
111ZNF274_21170338_ChIP-Seq_K562_Hela1.07415751
112SRF_21415370_ChIP-Seq_HL-1_Mouse1.07348088
113SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.06365608
114TAF15_26573619_Chip-Seq_HEK293_Human1.05724625
115BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.05724395
116ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.04504198
117E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.02849587
118BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.02754880
119EWS_26573619_Chip-Seq_HEK293_Human1.02748316
120SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02287723
121SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.02106650
122RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.01978732
123* ELK1_22589737_ChIP-Seq_MCF10A_Human1.01481992
124HOXB4_20404135_ChIP-ChIP_EML_Mouse1.01018841
125ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.00111369
126STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.99970519
127STAT3_18555785_ChIP-Seq_MESCs_Mouse0.99904853
128RBPJ_22232070_ChIP-Seq_NCS_Mouse0.99716593
129* TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.99212880
130PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.96650572
131FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.96047927
132* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.95685673
133P300_19829295_ChIP-Seq_ESCs_Human0.94077498
134NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.93383355
135* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.93152306
136* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93056594
137PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.92103472
138EGR1_19032775_ChIP-ChIP_M12_Human0.90062973
139TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.89338513
140CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.89314379
141MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.87791100
142CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.87359060
143KAP1_27257070_Chip-Seq_ESCs_Mouse0.86778763
144* NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.86335258
145FUS_26573619_Chip-Seq_HEK293_Human0.86121743
146NOTCH1_21737748_ChIP-Seq_TLL_Human0.85832552
147* POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.85806754
148GATA1_26923725_Chip-Seq_HPCs_Mouse0.85360933
149MYC_18940864_ChIP-ChIP_HL60_Human0.85277528
150NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.84838660
151SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.84072250
152TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.82813746
153SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.81959980
154FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.79955716
155KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.78673551
156* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.78550692
157SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.78245648
158SOX2_18555785_ChIP-Seq_MESCs_Mouse0.74882483
159TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.74328572
160* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.74247070
161EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.73827339
162* NANOG_18692474_ChIP-Seq_MEFs_Mouse0.73501742

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching6.31756358
2MP0003111_abnormal_nucleus_morphology4.83377909
3MP0004957_abnormal_blastocyst_morpholog4.46327214
4MP0003303_peritoneal_inflammation4.11749036
5MP0010094_abnormal_chromosome_stability3.95820848
6MP0004510_myositis3.85425102
7MP0003077_abnormal_cell_cycle3.76784760
8MP0008877_abnormal_DNA_methylation3.72889053
9MP0003718_maternal_effect3.64246190
10MP0008004_abnormal_stomach_pH3.26286897
11MP0008057_abnormal_DNA_replication3.12678084
12MP0008260_abnormal_autophagy3.08145468
13MP0008058_abnormal_DNA_repair3.01610005
14MP0003123_paternal_imprinting2.97358230
15MP0003724_increased_susceptibility_to2.78426471
16MP0002148_abnormal_hypersensitivity_rea2.57523008
17MP0003786_premature_aging2.51672811
18MP0008932_abnormal_embryonic_tissue2.45646854
19* MP0001730_embryonic_growth_arrest2.35616487
20MP0005464_abnormal_platelet_physiology2.32050139
21MP0001929_abnormal_gametogenesis2.26940962
22MP0000343_altered_response_to2.23214740
23MP0005410_abnormal_fertilization2.22547975
24MP0002210_abnormal_sex_determination2.20917271
25MP0000350_abnormal_cell_proliferation2.19289288
26MP0010307_abnormal_tumor_latency2.16712603
27MP0008007_abnormal_cellular_replicative2.16062646
28MP0003828_pulmonary_edema2.09331134
29MP0001853_heart_inflammation2.01223007
30MP0009764_decreased_sensitivity_to1.98660975
31MP0005380_embryogenesis_phenotype1.90670543
32MP0001672_abnormal_embryogenesis/_devel1.90670543
33MP0005167_abnormal_blood-brain_barrier1.88909034
34MP0001145_abnormal_male_reproductive1.87376781
35MP0003646_muscle_fatigue1.87178794
36MP0002653_abnormal_ependyma_morphology1.78813702
37MP0003698_abnormal_male_reproductive1.75732809
38MP0000751_myopathy1.70195101
39MP0000653_abnormal_sex_gland1.69562714
40MP0002254_reproductive_system_inflammat1.67775425
41MP0003075_altered_response_to1.66965727
42* MP0001697_abnormal_embryo_size1.66704077
43MP0001188_hyperpigmentation1.65757256
44MP0003806_abnormal_nucleotide_metabolis1.65112088
45MP0002736_abnormal_nociception_after1.64907736
46MP0003984_embryonic_growth_retardation1.60918516
47MP0002088_abnormal_embryonic_growth/wei1.57755203
48* MP0002080_prenatal_lethality1.57326020
49MP0000749_muscle_degeneration1.55199804
50MP0003453_abnormal_keratinocyte_physiol1.55044285
51MP0009333_abnormal_splenocyte_physiolog1.51351854
52MP0009785_altered_susceptibility_to1.46765751
53MP0003656_abnormal_erythrocyte_physiolo1.46189913
54MP0003121_genomic_imprinting1.39878429
55MP0000750_abnormal_muscle_regeneration1.39792660
56MP0002085_abnormal_embryonic_tissue1.39716443
57MP0003221_abnormal_cardiomyocyte_apopto1.39050408
58MP0004215_abnormal_myocardial_fiber1.39008063
59MP0002084_abnormal_developmental_patter1.38066905
60MP0002161_abnormal_fertility/fecundity1.37856220
61MP0010352_gastrointestinal_tract_polyps1.34594365
62MP0006082_CNS_inflammation1.33602475
63MP0002106_abnormal_muscle_physiology1.32172654
64MP0009765_abnormal_xenobiotic_induced1.29687736
65MP0002972_abnormal_cardiac_muscle1.29412133
66MP0002735_abnormal_chemical_nociception1.28806399
67MP0005058_abnormal_lysosome_morphology1.28424540
68MP0001501_abnormal_sleep_pattern1.26220652
69MP0003315_abnormal_perineum_morphology1.25933012
70MP0005397_hematopoietic_system_phenotyp1.25711834
71MP0001545_abnormal_hematopoietic_system1.25711834
72MP0005266_abnormal_metabolism1.24984605
73MP0003436_decreased_susceptibility_to1.24632576
74MP0000313_abnormal_cell_death1.24413672
75MP0004947_skin_inflammation1.23677409
76* MP0002086_abnormal_extraembryonic_tissu1.22853355
77MP0000358_abnormal_cell_content/1.22634843
78MP0002160_abnormal_reproductive_system1.22056862
79MP0005395_other_phenotype1.20118281
80MP0005165_increased_susceptibility_to1.17123080
81MP0005620_abnormal_muscle_contractility1.15023822
82MP0005389_reproductive_system_phenotype1.14884515
83MP0002837_dystrophic_cardiac_calcinosis1.13880628
84MP0003186_abnormal_redox_activity1.12956000
85MP0004233_abnormal_muscle_weight1.10762889
86MP0002102_abnormal_ear_morphology1.09750531
87MP0006276_abnormal_autonomic_nervous1.09355090
88MP0002019_abnormal_tumor_incidence1.08797965
89MP0002733_abnormal_thermal_nociception1.07701775
90MP0005000_abnormal_immune_tolerance1.07208289
91MP0005621_abnormal_cell_physiology1.04698461
92MP0005384_cellular_phenotype1.03770907
93MP0003950_abnormal_plasma_membrane1.03039967
94MP0000465_gastrointestinal_hemorrhage1.02714492
95MP0002796_impaired_skin_barrier1.00242921
96MP0009840_abnormal_foam_cell0.99870539
97MP0003699_abnormal_female_reproductive0.99859881
98MP0001119_abnormal_female_reproductive0.99713118
99MP0000579_abnormal_nail_morphology0.99422547
100MP0005084_abnormal_gallbladder_morpholo0.98009833
101MP0003567_abnormal_fetal_cardiomyocyte0.96586161
102MP0003878_abnormal_ear_physiology0.95864704
103MP0005377_hearing/vestibular/ear_phenot0.95864704
104MP0004087_abnormal_muscle_fiber0.95452590
105MP0002419_abnormal_innate_immunity0.94555458
106MP0005076_abnormal_cell_differentiation0.94233437
107MP0004270_analgesia0.91961792
108MP0001970_abnormal_pain_threshold0.91413870
109MP0001542_abnormal_bone_strength0.90968196
110MP0002163_abnormal_gland_morphology0.89611082
111MP0001533_abnormal_skeleton_physiology0.87475558
112MP0005535_abnormal_body_temperature0.87006600
113MP0004808_abnormal_hematopoietic_stem0.86905295
114MP0003119_abnormal_digestive_system0.85116496
115MP0009763_increased_sensitivity_to0.84031260
116MP0009672_abnormal_birth_weight0.83914639
117MP0004036_abnormal_muscle_relaxation0.83550931
118MP0000230_abnormal_systemic_arterial0.82895860
119MP0000383_abnormal_hair_follicle0.82863854
120MP0008995_early_reproductive_senescence0.81617318
121MP0004197_abnormal_fetal_growth/weight/0.81265149
122MP0000490_abnormal_crypts_of0.80910015
123MP0001529_abnormal_vocalization0.80346234
124MP0001919_abnormal_reproductive_system0.80005072
125MP0002452_abnormal_antigen_presenting0.79464272
126MP0001191_abnormal_skin_condition0.78907415
127MP0000627_abnormal_mammary_gland0.78561654
128MP0002723_abnormal_immune_serum0.76827471
129MP0006035_abnormal_mitochondrial_morpho0.76664761
130MP0005369_muscle_phenotype0.74882303
131MP0005647_abnormal_sex_gland0.74395521
132MP0003938_abnormal_ear_development0.72899246
133MP0003880_abnormal_central_pattern0.72459280
134MP0005666_abnormal_adipose_tissue0.70498289
135MP0005595_abnormal_vascular_smooth0.70346051
136MP0008874_decreased_physiological_sensi0.70142522
137MP0005187_abnormal_penis_morphology0.68676851
138MP0003448_altered_tumor_morphology0.67970869
139MP0001968_abnormal_touch/_nociception0.67837583
140MP0000747_muscle_weakness0.67774765
141MP0000759_abnormal_skeletal_muscle0.66862631
142MP0000647_abnormal_sebaceous_gland0.65824907
143MP0003787_abnormal_imprinting0.64870384
144MP0001727_abnormal_embryo_implantation0.63533998
145MP0002396_abnormal_hematopoietic_system0.63460093
146MP0003890_abnormal_embryonic-extraembry0.63241925
147MP0009703_decreased_birth_body0.62570426
148MP0009697_abnormal_copulation0.62171412
149MP0004084_abnormal_cardiac_muscle0.62019173
150MP0003300_gastrointestinal_ulcer0.61670882
151MP0001661_extended_life_span0.60920000
152MP0003861_abnormal_nervous_system0.60876348
153MP0000858_altered_metastatic_potential0.59780202
154MP0001849_ear_inflammation0.59510263
155MP0010234_abnormal_vibrissa_follicle0.59321657
156MP0006036_abnormal_mitochondrial_physio0.58058183
157MP0004264_abnormal_extraembryonic_tissu0.57550043
158MP0005451_abnormal_body_composition0.57462050
159MP0003879_abnormal_hair_cell0.56793064
160MP0002332_abnormal_exercise_endurance0.54540455
161MP0003941_abnormal_skin_development0.53551541
162MP0002269_muscular_atrophy0.53530237
163MP0001293_anophthalmia0.52827207
164MP0003936_abnormal_reproductive_system0.52283252
165MP0002127_abnormal_cardiovascular_syste0.52257404
166MP0000703_abnormal_thymus_morphology0.51143625
167MP0003937_abnormal_limbs/digits/tail_de0.51064506
168MP0002169_no_abnormal_phenotype0.50063681
169MP0002873_normal_phenotype0.49036604
170MP0009278_abnormal_bone_marrow0.44890601

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)6.48536725
2Breast hypoplasia (HP:0003187)5.58247180
3Nemaline bodies (HP:0003798)5.06523995
4Muscle fiber inclusion bodies (HP:0100299)4.79468752
5Impulsivity (HP:0100710)4.75393552
6Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.69589624
7Carpal bone hypoplasia (HP:0001498)4.17881598
8Abnormality of the labia minora (HP:0012880)4.03285469
9Patellar aplasia (HP:0006443)3.94407919
10Cerebral hypomyelination (HP:0006808)3.92571715
11Aplasia/Hypoplasia of the patella (HP:0006498)3.89165634
12Degeneration of anterior horn cells (HP:0002398)3.82222259
13Abnormality of the anterior horn cell (HP:0006802)3.82222259
14Disinhibition (HP:0000734)3.78878919
15* Rimmed vacuoles (HP:0003805)3.76099464
16* Shoulder girdle muscle weakness (HP:0003547)3.73973888
17Rough bone trabeculation (HP:0100670)3.72339004
18Axonal loss (HP:0003447)3.57776371
19Exercise-induced muscle cramps (HP:0003710)3.44992136
20Mutism (HP:0002300)3.40675811
21Premature ovarian failure (HP:0008209)3.34267626
22Abnormality of alanine metabolism (HP:0010916)3.28797048
23Hyperalaninemia (HP:0003348)3.28797048
24Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.28797048
25Abnormal spermatogenesis (HP:0008669)3.05181500
26Atrophy/Degeneration involving motor neurons (HP:0007373)3.04682245
27Hyperglycinemia (HP:0002154)3.04248117
28Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.02828446
29Bundle branch block (HP:0011710)3.00483810
30Secondary amenorrhea (HP:0000869)2.92513459
31Atonic seizures (HP:0010819)2.91407794
32Male infertility (HP:0003251)2.90114428
33Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.89522653
34Prolonged bleeding time (HP:0003010)2.89406911
35Entropion (HP:0000621)2.83336632
36Stomatitis (HP:0010280)2.82621720
37Abnormal trabecular bone morphology (HP:0100671)2.82485593
38Abnormality of liposaccharide metabolism (HP:0010968)2.79000103
39Abnormality of glycosphingolipid metabolism (HP:0004343)2.79000103
40Abnormality of glycolipid metabolism (HP:0010969)2.79000103
41Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.77461049
42Failure to thrive in infancy (HP:0001531)2.76968924
43Hypoplasia of the capital femoral epiphysis (HP:0003090)2.74342166
44Personality changes (HP:0000751)2.72765166
45Absent radius (HP:0003974)2.71044906
46Inappropriate behavior (HP:0000719)2.68968517
47Delusions (HP:0000746)2.68313475
48Abnormality of lateral ventricle (HP:0030047)2.67462607
49Apathy (HP:0000741)2.67052217
50Ureteral duplication (HP:0000073)2.66909783
51Oral leukoplakia (HP:0002745)2.64927567
52Diminished motivation (HP:0000745)2.63770919
53Amyotrophic lateral sclerosis (HP:0007354)2.63409703
54Impaired vibration sensation in the lower limbs (HP:0002166)2.61999898
55Petechiae (HP:0000967)2.61950393
56CNS hypomyelination (HP:0003429)2.61820828
57Breast aplasia (HP:0100783)2.61472324
58Facial hemangioma (HP:0000329)2.58265181
59Paralysis (HP:0003470)2.56571560
60Gout (HP:0001997)2.56112040
61Absent forearm bone (HP:0003953)2.55162188
62Aplasia involving forearm bones (HP:0009822)2.55162188
63Oligodactyly (hands) (HP:0001180)2.53693653
64Polyphagia (HP:0002591)2.51398219
65Microretrognathia (HP:0000308)2.47424309
66EMG: myopathic abnormalities (HP:0003458)2.45836526
67Multiple enchondromatosis (HP:0005701)2.45787020
68Distal lower limb amyotrophy (HP:0008944)2.44500079
69Upper limb muscle weakness (HP:0003484)2.44299428
70Chromosomal breakage induced by crosslinking agents (HP:0003221)2.43454535
71Areflexia of lower limbs (HP:0002522)2.42961628
72Vacuolated lymphocytes (HP:0001922)2.42397756
73Upper motor neuron abnormality (HP:0002127)2.41846966
74Infertility (HP:0000789)2.41393034
75Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.39899955
76Aplasia/Hypoplasia of the breasts (HP:0010311)2.38128551
77Horseshoe kidney (HP:0000085)2.37336266
78Shawl scrotum (HP:0000049)2.37025366
79Progressive muscle weakness (HP:0003323)2.36460961
80Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.36239693
81Type 1 muscle fiber predominance (HP:0003803)2.35237291
82Tetraparesis (HP:0002273)2.33694778
83Global brain atrophy (HP:0002283)2.32405651
84Death in infancy (HP:0001522)2.31938082
85Exercise-induced myalgia (HP:0003738)2.30780458
86Abnormality of the vasculature of the conjunctiva (HP:0008054)2.30399167
87Ependymoma (HP:0002888)2.30246299
88Azoospermia (HP:0000027)2.30155601
89Oligodactyly (HP:0012165)2.29700691
90Cleft eyelid (HP:0000625)2.29107068
91Abnormality of the preputium (HP:0100587)2.28766525
92Abnormality of the umbilical cord (HP:0010881)2.27997413
93Meckel diverticulum (HP:0002245)2.27098530
94Increased mean platelet volume (HP:0011877)2.24903368
95Chromsome breakage (HP:0040012)2.24336161
96Tetraplegia (HP:0002445)2.22725262
97Loss of speech (HP:0002371)2.21049256
98Abnormality of the left ventricular outflow tract (HP:0011103)2.20941938
99Subaortic stenosis (HP:0001682)2.20941938
100Abnormal respiratory epithelium morphology (HP:0012253)2.18968781
101Abnormal respiratory motile cilium morphology (HP:0005938)2.18968781
102Lower limb amyotrophy (HP:0007210)2.18643838
103Dysautonomia (HP:0002459)2.18459724
104Fused cervical vertebrae (HP:0002949)2.18410929
105Increased cerebral lipofuscin (HP:0011813)2.18261058
106Distal lower limb muscle weakness (HP:0009053)2.16488660
107Urinary bladder sphincter dysfunction (HP:0002839)2.14676144
108Neoplasm of the pancreas (HP:0002894)2.13457757
109Parakeratosis (HP:0001036)2.13261738
110Distal arthrogryposis (HP:0005684)2.12675427
111Rhinitis (HP:0012384)2.12631853
112Unsteady gait (HP:0002317)2.11807316
113Spastic gait (HP:0002064)2.11554831
114Atrioventricular block (HP:0001678)2.11553047
115Weak cry (HP:0001612)2.10566852
116Nausea (HP:0002018)2.10174791
117Hyperglycinuria (HP:0003108)2.10011219
118Frequent falls (HP:0002359)2.09832441
119Abnormality of the ileum (HP:0001549)2.08300198
120Diplopia (HP:0000651)2.08223222
121Abnormality of binocular vision (HP:0011514)2.08223222
122Limb-girdle muscle atrophy (HP:0003797)2.08090429
123Prominent nose (HP:0000448)2.07858402
124Abnormality of the lower motor neuron (HP:0002366)2.07692734
125Cortical dysplasia (HP:0002539)2.07354820
126Peripheral hypomyelination (HP:0007182)2.07106695
127Absent/shortened dynein arms (HP:0200106)2.06926086
128Dynein arm defect of respiratory motile cilia (HP:0012255)2.06926086
129Abnormality of chromosome stability (HP:0003220)2.04544848
130Spinal muscular atrophy (HP:0007269)2.04008797
131Bone marrow hypocellularity (HP:0005528)2.03186266
132Chronic bronchitis (HP:0004469)2.01832939
133Urinary urgency (HP:0000012)2.01766831
134Pancreatic fibrosis (HP:0100732)2.01610479
135Ventricular fibrillation (HP:0001663)2.01408284
136Abnormality of serum amino acid levels (HP:0003112)2.01171940
137Myopathic facies (HP:0002058)2.01072875
138Aplasia/Hypoplasia involving the musculature (HP:0001460)2.00990556
139Aplasia/Hypoplasia of the uvula (HP:0010293)2.00990096
140Amaurosis fugax (HP:0100576)2.00132967
141Absent hand (HP:0004050)2.00093011
142Postnatal microcephaly (HP:0005484)2.00080192
143Agnosia (HP:0010524)1.99102311
144Aplasia/hypoplasia of the humerus (HP:0006507)1.98779976
145Rhabdomyolysis (HP:0003201)1.97855344
146Facial cleft (HP:0002006)1.97409337
147Supernumerary spleens (HP:0009799)1.97066985
148Abnormality of the vocal cords (HP:0008777)1.96099300
149Abnormal neuron morphology (HP:0012757)1.96018006
150Abnormality of the motor neurons (HP:0002450)1.96018006
151Absent epiphyses (HP:0010577)1.95497454
152Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.95497454
153Short nail (HP:0001799)1.95390827
154Sparse lateral eyebrow (HP:0005338)1.92396128
155Abnormal hair whorl (HP:0010721)1.91937374
156Irregular epiphyses (HP:0010582)1.91522825
157Trismus (HP:0000211)1.91257503
158Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.90541520
159Degeneration of the lateral corticospinal tracts (HP:0002314)1.90541520
160Neurofibrillary tangles (HP:0002185)1.90412538
161Muscle fiber atrophy (HP:0100295)1.89919426
162Spastic diplegia (HP:0001264)1.89495478
163Malignant hyperthermia (HP:0002047)1.89033243
164Absent thumb (HP:0009777)1.88973210
165Dyschromatopsia (HP:0007641)1.88443750
166Abnormal platelet volume (HP:0011876)1.87255414
167Neck muscle weakness (HP:0000467)1.87174350
168Autoimmune thrombocytopenia (HP:0001973)1.86245006
169Erythroderma (HP:0001019)1.85557240
170Lower limb muscle weakness (HP:0007340)1.85400966
171Small intestinal stenosis (HP:0012848)1.85280225
172Duodenal stenosis (HP:0100867)1.85280225
173Capillary hemangiomas (HP:0005306)1.83949278
174Neuronal loss in central nervous system (HP:0002529)1.82899317
175Myoglobinuria (HP:0002913)1.81328890
176Limb dystonia (HP:0002451)1.79492489
177Conjunctival telangiectasia (HP:0000524)1.78830816
178Autoamputation (HP:0001218)1.76637470
179Purpura (HP:0000979)1.76087485
180Sensorimotor neuropathy (HP:0007141)1.74853238
181Dysphonia (HP:0001618)1.74258612
182Increased neuronal autofluorescent lipopigment (HP:0002074)1.73755300
183Abnormality of the corticospinal tract (HP:0002492)1.72457078
184Centrally nucleated skeletal muscle fibers (HP:0003687)1.71212564
185Nasal speech (HP:0001611)1.71081560
186Fasciculations (HP:0002380)1.70094578
187Dialeptic seizures (HP:0011146)1.69669047

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.58908392
2WEE14.26874291
3AKT33.31553291
4IRAK33.20241542
5TAOK23.07228463
6NEK22.95877917
7EIF2AK12.93406787
8STK162.81743059
9PLK42.80766313
10EPHA22.70034384
11PDK42.67373645
12PDK32.67373645
13TSSK62.64459385
14PNCK2.46128244
15GRK72.43346990
16OBSCN2.24824212
17ARAF2.24659299
18TTK2.09349333
19ACVR1B2.07029093
20CDC72.04383507
21DYRK32.03613185
22NEK12.02078531
23BRSK22.00062324
24PLK31.97421241
25BRAF1.94672001
26PLK11.89517504
27MAP3K91.85722509
28PDK21.79242659
29NME21.73666031
30MATK1.71156180
31SRPK11.70485390
32LIMK11.67532529
33CDK191.63285615
34BCKDK1.59149886
35BMX1.58848159
36CCNB11.57487103
37TTN1.57136257
38FGR1.55567277
39LATS21.54618469
40TBK11.50600835
41BRSK11.43854811
42TRIM281.42269147
43MAP3K141.37930292
44CHEK21.37680146
45EIF2AK31.34116948
46RPS6KA41.27588024
47IKBKB1.23155856
48RIPK41.21278469
49MST41.19566949
50PHKG21.17630874
51PHKG11.17630874
52SIK31.11001744
53AURKB1.09621965
54PBK1.08480971
55MAP2K71.07527524
56ERBB31.04648519
57AURKA1.04240278
58STK38L1.02120504
59STK31.01999562
60IRAK11.00961816
61MAP3K111.00723604
62ERBB40.99620684
63KSR20.99302495
64TESK20.98554127
65TAOK30.94502517
66KSR10.93193474
67MAP3K50.91673654
68RAF10.91415230
69PKN10.91086249
70BMPR20.90487807
71MKNK20.89684943
72CHEK10.87525083
73IRAK20.84739761
74CDK40.81853749
75TESK10.81426278
76MAPKAPK50.80001916
77ATR0.79822934
78MKNK10.79207926
79ALK0.78647881
80MAP3K80.78320355
81ZAK0.76709773
82TEC0.74374495
83VRK10.74256206
84PAK10.71243058
85DAPK20.70938573
86PIM20.70439968
87MAP3K40.68930934
88PINK10.67873163
89MAP3K30.66615774
90CASK0.66598623
91MAP3K120.66554307
92SCYL20.65900180
93RIPK10.64099935
94WNK30.63175970
95CDK70.62269485
96CDK20.62035813
97MELK0.61273073
98DYRK1B0.61222343
99DYRK1A0.60939836
100TAOK10.60562632
101ADRBK20.60366939
102DYRK20.60241066
103EGFR0.58801284
104IKBKE0.56615983
105NME10.56432305
106MINK10.56087313
107MAP2K30.55988935
108MARK10.54800790
109MAPK150.53379950
110CAMK2A0.53286835
111CAMK2G0.53235265
112DDR20.51830374
113PRKCI0.50745987
114PAK60.50385962
115PLK20.49198909
116PIM10.49176164
117CHUK0.47988400
118CSNK1E0.45427700
119MARK30.45059034
120ATM0.44351454
121RPS6KB20.43388075
122TIE10.43201590
123CDK10.43121737
124CSNK2A10.42935248
125CAMK2D0.42413250
126STK380.42291552
127CSNK2A20.41098030
128RPS6KA10.40611268
129CDK60.39341070
130MAPK130.38928437
131CSNK1G30.38718576
132BCR0.38302921
133TYRO30.37435859
134IRAK40.37400625
135EPHA30.36730476
136GSK3A0.34476851
137CDK140.32450834
138EIF2AK20.32103195
139CSNK1G20.31906944
140PRKD30.31811909
141CAMKK20.31709443
142PRKCG0.30762099
143PAK40.29730920
144MOS0.29565353
145STK240.28931374
146CDK80.27062307
147CDK180.25389501
148MAPKAPK30.25002361
149GRK50.23213740
150CDK150.22572800
151STK100.21062853
152CDK11A0.21045006
153MAPK100.20811495
154CSNK1G10.19339185
155ABL20.19207000
156PRKAA10.19065913
157DAPK10.18212781
158MAP2K10.18005378

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007505.19003331
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.51241201
3Proteasome_Homo sapiens_hsa030504.09619995
4RNA polymerase_Homo sapiens_hsa030204.01898856
5RNA transport_Homo sapiens_hsa030133.76678270
6Cell cycle_Homo sapiens_hsa041102.80671926
7Spliceosome_Homo sapiens_hsa030402.76124440
8DNA replication_Homo sapiens_hsa030302.62793676
9Basal transcription factors_Homo sapiens_hsa030222.62016624
10Salmonella infection_Homo sapiens_hsa051322.35364570
11Regulation of autophagy_Homo sapiens_hsa041402.34925367
12Pyrimidine metabolism_Homo sapiens_hsa002402.31007428
13Mismatch repair_Homo sapiens_hsa034302.21992022
14RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.13043910
15Toll-like receptor signaling pathway_Homo sapiens_hsa046202.10148924
16Oocyte meiosis_Homo sapiens_hsa041142.07569962
17Nucleotide excision repair_Homo sapiens_hsa034201.92852038
18TNF signaling pathway_Homo sapiens_hsa046681.87789158
19Base excision repair_Homo sapiens_hsa034101.85744993
20mRNA surveillance pathway_Homo sapiens_hsa030151.75884640
21Homologous recombination_Homo sapiens_hsa034401.75850195
22p53 signaling pathway_Homo sapiens_hsa041151.74699102
23Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.73397937
24Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.68052716
25Pertussis_Homo sapiens_hsa051331.62308344
26Epstein-Barr virus infection_Homo sapiens_hsa051691.59164001
27Fanconi anemia pathway_Homo sapiens_hsa034601.57666236
28NF-kappa B signaling pathway_Homo sapiens_hsa040641.56652798
29RNA degradation_Homo sapiens_hsa030181.52684234
30Malaria_Homo sapiens_hsa051441.52064874
31Purine metabolism_Homo sapiens_hsa002301.50216282
32African trypanosomiasis_Homo sapiens_hsa051431.44652643
33Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.42133255
34Parkinsons disease_Homo sapiens_hsa050121.40188110
35Osteoclast differentiation_Homo sapiens_hsa043801.35521706
36Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.30520529
37Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.27581118
38Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.26316051
39SNARE interactions in vesicular transport_Homo sapiens_hsa041301.21885095
40Folate biosynthesis_Homo sapiens_hsa007901.16485774
41Pentose phosphate pathway_Homo sapiens_hsa000301.16153338
42Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.13322224
43Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.10482324
44Glycerophospholipid metabolism_Homo sapiens_hsa005641.10342028
45Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.08811622
46Oxidative phosphorylation_Homo sapiens_hsa001901.05584020
47Ribosome_Homo sapiens_hsa030101.04340626
48Cysteine and methionine metabolism_Homo sapiens_hsa002701.03771331
49Phototransduction_Homo sapiens_hsa047441.01302904
50Asthma_Homo sapiens_hsa053100.99286591
51mTOR signaling pathway_Homo sapiens_hsa041500.98707561
52Collecting duct acid secretion_Homo sapiens_hsa049660.93712343
53Hematopoietic cell lineage_Homo sapiens_hsa046400.93122282
54Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.89746039
55Cardiac muscle contraction_Homo sapiens_hsa042600.88093898
56Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.87600469
57Circadian rhythm_Homo sapiens_hsa047100.87047144
58MAPK signaling pathway_Homo sapiens_hsa040100.85553538
59Dilated cardiomyopathy_Homo sapiens_hsa054140.85172212
60Amoebiasis_Homo sapiens_hsa051460.84783428
61Transcriptional misregulation in cancer_Homo sapiens_hsa052020.84257777
62Platelet activation_Homo sapiens_hsa046110.82518284
63Protein export_Homo sapiens_hsa030600.82484552
64Antigen processing and presentation_Homo sapiens_hsa046120.81584251
65Leishmaniasis_Homo sapiens_hsa051400.80733577
66Toxoplasmosis_Homo sapiens_hsa051450.80038575
67Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.79892776
68Chemokine signaling pathway_Homo sapiens_hsa040620.79083835
69Legionellosis_Homo sapiens_hsa051340.78421877
70Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.76350170
71Sulfur metabolism_Homo sapiens_hsa009200.75502891
72Viral myocarditis_Homo sapiens_hsa054160.74524448
73Synaptic vesicle cycle_Homo sapiens_hsa047210.73263731
74Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.72380971
75Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.71091356
76Viral carcinogenesis_Homo sapiens_hsa052030.68745750
77Long-term depression_Homo sapiens_hsa047300.66885438
78Steroid biosynthesis_Homo sapiens_hsa001000.66649143
79Herpes simplex infection_Homo sapiens_hsa051680.66500100
80Alzheimers disease_Homo sapiens_hsa050100.63460491
81Gap junction_Homo sapiens_hsa045400.62568286
82FoxO signaling pathway_Homo sapiens_hsa040680.61571901
83Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.60696295
84One carbon pool by folate_Homo sapiens_hsa006700.60502093
85Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.60129875
86Fatty acid elongation_Homo sapiens_hsa000620.60062550
87Fructose and mannose metabolism_Homo sapiens_hsa000510.59142584
88Bladder cancer_Homo sapiens_hsa052190.58198518
89Serotonergic synapse_Homo sapiens_hsa047260.56143884
90Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.55180084
91Huntingtons disease_Homo sapiens_hsa050160.52937866
92NOD-like receptor signaling pathway_Homo sapiens_hsa046210.51821574
93Drug metabolism - other enzymes_Homo sapiens_hsa009830.51780059
94Longevity regulating pathway - mammal_Homo sapiens_hsa042110.51208195
95Biosynthesis of amino acids_Homo sapiens_hsa012300.50667252
96Oxytocin signaling pathway_Homo sapiens_hsa049210.49792563
97Hepatitis C_Homo sapiens_hsa051600.48353112
98Calcium signaling pathway_Homo sapiens_hsa040200.45481877
99GABAergic synapse_Homo sapiens_hsa047270.44985743
100HTLV-I infection_Homo sapiens_hsa051660.44930033
101Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.44033608
102Type I diabetes mellitus_Homo sapiens_hsa049400.43769145
103Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.42797562
104Graft-versus-host disease_Homo sapiens_hsa053320.42429604
105Adipocytokine signaling pathway_Homo sapiens_hsa049200.41507305
106Acute myeloid leukemia_Homo sapiens_hsa052210.41460737
107Rheumatoid arthritis_Homo sapiens_hsa053230.41270380
108Non-homologous end-joining_Homo sapiens_hsa034500.41217032
109Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.41116606
110Jak-STAT signaling pathway_Homo sapiens_hsa046300.41001705
111Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.40859297
112Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.40834982
113Renal cell carcinoma_Homo sapiens_hsa052110.40344227
114Selenocompound metabolism_Homo sapiens_hsa004500.39869851
115HIF-1 signaling pathway_Homo sapiens_hsa040660.39645204
116Shigellosis_Homo sapiens_hsa051310.39191730
117Long-term potentiation_Homo sapiens_hsa047200.38097164
118Dorso-ventral axis formation_Homo sapiens_hsa043200.37947690
119Thyroid cancer_Homo sapiens_hsa052160.37280880
120Influenza A_Homo sapiens_hsa051640.37190694
121Colorectal cancer_Homo sapiens_hsa052100.36473521
122Inositol phosphate metabolism_Homo sapiens_hsa005620.35212560
123Apoptosis_Homo sapiens_hsa042100.34155893
124Hippo signaling pathway_Homo sapiens_hsa043900.30423667
125Vitamin digestion and absorption_Homo sapiens_hsa049770.30381757
126Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.29890994
127Hepatitis B_Homo sapiens_hsa051610.29877066
128MicroRNAs in cancer_Homo sapiens_hsa052060.29395524
129Allograft rejection_Homo sapiens_hsa053300.29308265
130Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.25351870
131Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.24414083
132Amphetamine addiction_Homo sapiens_hsa050310.23559829
133Prion diseases_Homo sapiens_hsa050200.23263035
134Thyroid hormone signaling pathway_Homo sapiens_hsa049190.22446895
135Endocytosis_Homo sapiens_hsa041440.21801231
136Measles_Homo sapiens_hsa051620.20994627
137Carbon metabolism_Homo sapiens_hsa012000.20543978
138VEGF signaling pathway_Homo sapiens_hsa043700.19624698
139Small cell lung cancer_Homo sapiens_hsa052220.19559747
140Glucagon signaling pathway_Homo sapiens_hsa049220.18389381
141Lysosome_Homo sapiens_hsa041420.16070843
142Nicotine addiction_Homo sapiens_hsa050330.14830047
143Estrogen signaling pathway_Homo sapiens_hsa049150.13029946
144Tuberculosis_Homo sapiens_hsa051520.12582589
145AMPK signaling pathway_Homo sapiens_hsa041520.12254240
146Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.11818141
147Vibrio cholerae infection_Homo sapiens_hsa051100.11014711
148Endometrial cancer_Homo sapiens_hsa052130.10869734
149Insulin signaling pathway_Homo sapiens_hsa049100.10608034
150Intestinal immune network for IgA production_Homo sapiens_hsa046720.10082871
151Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.09575817
152Phagosome_Homo sapiens_hsa041450.08667392
153Renin-angiotensin system_Homo sapiens_hsa046140.08661858

Most similar genes based on co-expression Upload to Enrichr

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