DNAJB9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the J protein family. J proteins function in many cellular processes by regulating the ATPase activity of 70 kDa heat shock proteins. This gene is a member of the type 2 subgroup of DnaJ proteins. The encoded protein is localized to the endoplasmic reticulum. This protein is induced by endoplasmic reticulum stress and plays a role in protecting stressed cells from apoptosis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)9.63168662
2Golgi transport vesicle coating (GO:0048200)9.63168662
3maintenance of protein localization in endoplasmic reticulum (GO:0035437)7.17274400
4COPII vesicle coating (GO:0048208)6.77657704
5protein retention in ER lumen (GO:0006621)6.30589833
6regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022356.19773005
7signal peptide processing (GO:0006465)5.85811746
8endocrine pancreas development (GO:0031018)5.79800693
9protein maturation by protein folding (GO:0022417)5.75928182
10peptide hormone processing (GO:0016486)5.53017516
11retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)5.43218060
12* activation of signaling protein activity involved in unfolded protein response (GO:0006987)5.18876037
13ER overload response (GO:0006983)5.04304121
14UDP-N-acetylglucosamine metabolic process (GO:0006047)4.95918541
15* positive regulation of nuclease activity (GO:0032075)4.92823168
16regulation of type B pancreatic cell apoptotic process (GO:2000674)4.78869555
17glandular epithelial cell differentiation (GO:0002067)4.76097435
18type B pancreatic cell development (GO:0003323)4.75984344
19exocrine pancreas development (GO:0031017)4.75804803
20* regulation of nuclease activity (GO:0032069)4.51815780
21* endoplasmic reticulum unfolded protein response (GO:0030968)4.50849971
22vesicle coating (GO:0006901)4.48481200
23* cellular response to unfolded protein (GO:0034620)4.43270161
24* ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)4.32921484
25* cellular response to topologically incorrect protein (GO:0035967)4.27732925
26glandular epithelial cell development (GO:0002068)4.23135718
27* ER-nucleus signaling pathway (GO:0006984)4.22831288
28sequestering of metal ion (GO:0051238)4.13969817
29negative regulation of glycoprotein biosynthetic process (GO:0010561)4.02378672
30positive regulation of insulin secretion (GO:0032024)3.94646804
31erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.87110089
32L-phenylalanine catabolic process (GO:0006559)3.87110089
33* response to endoplasmic reticulum stress (GO:0034976)3.76721873
34ER to Golgi vesicle-mediated transport (GO:0006888)3.74564000
35protein N-linked glycosylation via asparagine (GO:0018279)3.72586980
36columnar/cuboidal epithelial cell development (GO:0002066)3.70451262
37peptidyl-asparagine modification (GO:0018196)3.70443393
38nucleotide-sugar biosynthetic process (GO:0009226)3.67066977
39macroautophagy (GO:0016236)3.64924580
404-hydroxyproline metabolic process (GO:0019471)3.60130284
41L-phenylalanine metabolic process (GO:0006558)3.57003084
42erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.57003084
43toxin metabolic process (GO:0009404)3.55264815
44regulation of hexokinase activity (GO:1903299)3.53910306
45regulation of glucokinase activity (GO:0033131)3.53910306
46* response to unfolded protein (GO:0006986)3.53614460
47cellular ketone body metabolic process (GO:0046950)3.48308161
48cell wall macromolecule catabolic process (GO:0016998)3.48259389
49* response to topologically incorrect protein (GO:0035966)3.46408518
50protein N-linked glycosylation (GO:0006487)3.42558885
51L-alpha-amino acid transmembrane transport (GO:1902475)3.42432874
52insulin secretion (GO:0030073)3.41326915
53intestinal epithelial cell development (GO:0060576)3.40904384
54cellular zinc ion homeostasis (GO:0006882)3.40159670
55positive regulation of mitochondrial fission (GO:0090141)3.37991593
56negative regulation of glycoprotein metabolic process (GO:1903019)3.36520202
57positive regulation of peptide hormone secretion (GO:0090277)3.32821461
58intestinal cholesterol absorption (GO:0030299)3.26173340
59Golgi organization (GO:0007030)3.20987102
60intra-Golgi vesicle-mediated transport (GO:0006891)3.20868726
61positive regulation of glycolytic process (GO:0045821)3.19445187
62positive regulation of peptide secretion (GO:0002793)3.16872522
63regulation of insulin secretion (GO:0050796)3.15691760
64phenylpropanoid metabolic process (GO:0009698)3.10630830
65ketone body metabolic process (GO:1902224)3.08304356
66regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.00385101
67intestinal absorption (GO:0050892)2.99560022
68interleukin-6-mediated signaling pathway (GO:0070102)2.99227584
69cell redox homeostasis (GO:0045454)2.97969598
70negative regulation of bone resorption (GO:0045779)2.90511665
71protein localization to cilium (GO:0061512)2.90415166
72regulation of peptide hormone secretion (GO:0090276)2.90375571
73nucleotide-sugar metabolic process (GO:0009225)2.89220010
74retinal metabolic process (GO:0042574)2.88626595
75cell wall macromolecule metabolic process (GO:0044036)2.87657387
76magnesium ion transport (GO:0015693)2.86222201
77protein localization to Golgi apparatus (GO:0034067)2.85653023
78establishment of protein localization to Golgi (GO:0072600)2.83939900
79response to hexose (GO:0009746)2.83767955
80regulation of peptide secretion (GO:0002791)2.83583885
81cellular response to vitamin D (GO:0071305)2.82951308
82nitric oxide mediated signal transduction (GO:0007263)2.82566333
83transcytosis (GO:0045056)2.81501920
84regulation of cholesterol homeostasis (GO:2000188)2.81061483
85negative regulation of acute inflammatory response (GO:0002674)2.79520811
86sulfur amino acid catabolic process (GO:0000098)2.79180900
87regulation of Golgi to plasma membrane protein transport (GO:0042996)2.79119808
88GDP-mannose metabolic process (GO:0019673)2.77681400
89response to lipoprotein particle (GO:0055094)2.77581544
90keratinocyte development (GO:0003334)2.77577353
91glycosphingolipid biosynthetic process (GO:0006688)2.76999414
92interleukin-1-mediated signaling pathway (GO:0070498)2.76617498
93response to glucose (GO:0009749)2.76266838
94aromatic amino acid family catabolic process (GO:0009074)2.74197941
95valine metabolic process (GO:0006573)2.73726934
96negative regulation of glycogen biosynthetic process (GO:0045719)2.73184713
97regulation of immunoglobulin secretion (GO:0051023)2.71530217
98nucleotide transmembrane transport (GO:1901679)2.70203378
99response to monosaccharide (GO:0034284)2.69502996
100peptide metabolic process (GO:0006518)2.68619469
101tricarboxylic acid metabolic process (GO:0072350)2.66244359
1023-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.61444919
103purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.61444919
104protein carboxylation (GO:0018214)2.60225413
105peptidyl-glutamic acid carboxylation (GO:0017187)2.60225413
106carbohydrate homeostasis (GO:0033500)2.60016559
107glucose homeostasis (GO:0042593)2.60016559
108regulation of energy homeostasis (GO:2000505)2.59623754
109retrograde transport, vesicle recycling within Golgi (GO:0000301)2.59296402
110positive regulation of hormone secretion (GO:0046887)2.58576452
111zinc ion homeostasis (GO:0055069)2.58202574
112Golgi vesicle transport (GO:0048193)2.57773675
113drug transmembrane transport (GO:0006855)2.55273441
114peptide secretion (GO:0002790)2.53844043
115maintenance of protein localization in organelle (GO:0072595)2.52623575
116pyrimidine-containing compound transmembrane transport (GO:0072531)2.51952506
117protein targeting to Golgi (GO:0000042)2.50986826
118peptide hormone secretion (GO:0030072)2.50770316
119detection of calcium ion (GO:0005513)2.48598691
120RNA destabilization (GO:0050779)2.47436385
121positive regulation of protein autophosphorylation (GO:0031954)2.47214258
122negative regulation of neurological system process (GO:0031645)2.45583772
123negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.44000756
124acrosome assembly (GO:0001675)2.43941094
125vascular smooth muscle contraction (GO:0014829)2.42367107
126regulation of protein glycosylation (GO:0060049)2.41070321
127bile acid biosynthetic process (GO:0006699)2.40253271
128xenobiotic catabolic process (GO:0042178)2.38417557
129cellular glucuronidation (GO:0052695)2.37458859
130membrane budding (GO:0006900)2.35129193
131regulation of transmission of nerve impulse (GO:0051969)2.34863215
132platelet dense granule organization (GO:0060155)2.34860297
133amino acid salvage (GO:0043102)2.34457643
134L-methionine salvage (GO:0071267)2.34457643
135L-methionine biosynthetic process (GO:0071265)2.34457643
136glucuronate metabolic process (GO:0019585)2.34150581
137uronic acid metabolic process (GO:0006063)2.34150581
138nonmotile primary cilium assembly (GO:0035058)2.27819332
139tryptophan catabolic process (GO:0006569)2.27786225
140indole-containing compound catabolic process (GO:0042436)2.27786225
141indolalkylamine catabolic process (GO:0046218)2.27786225
142response to redox state (GO:0051775)2.26512284
143mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.26268213
144positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.26268213
145inositol phosphate dephosphorylation (GO:0046855)2.24075290
146phosphorylated carbohydrate dephosphorylation (GO:0046838)2.24075290
147positive regulation of calcium ion import (GO:0090280)2.23289496
148epoxygenase P450 pathway (GO:0019373)2.22990850
149negative regulation of endothelial cell apoptotic process (GO:2000352)2.22851437
150regulation of cilium movement (GO:0003352)2.22578758
151seminiferous tubule development (GO:0072520)2.22216289
152S-adenosylmethionine metabolic process (GO:0046500)2.21766872
153Golgi to plasma membrane protein transport (GO:0043001)2.21375664
154negative regulation of complement activation (GO:0045916)2.17981587
155zinc ion transport (GO:0006829)2.17299180
156inositol phosphate catabolic process (GO:0071545)2.16194446
157negative regulation of protein activation cascade (GO:2000258)2.15533298
158piRNA metabolic process (GO:0034587)2.14907036
159oxidative demethylation (GO:0070989)2.10980746
160peroxisome fission (GO:0016559)2.10646903
161negative regulation of gluconeogenesis (GO:0045721)2.09674813
162neural tube formation (GO:0001841)2.08520828
163L-serine transport (GO:0015825)2.07181558
164negative regulation of lipid catabolic process (GO:0050995)2.06260939
165water-soluble vitamin biosynthetic process (GO:0042364)2.06177682
166negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.05789989
167L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.05720979
168axoneme assembly (GO:0035082)2.04405869
169artery smooth muscle contraction (GO:0014824)2.01850143
170cellular response to leptin stimulus (GO:0044320)2.01712053
171cellular biogenic amine catabolic process (GO:0042402)2.01699391
172amine catabolic process (GO:0009310)2.01699391
173regulation of heat generation (GO:0031650)2.01263652
174regulation of meiosis I (GO:0060631)2.00841909
175epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.00841393
176glycerophospholipid catabolic process (GO:0046475)2.00048827
177phospholipid homeostasis (GO:0055091)1.99052097
178kynurenine metabolic process (GO:0070189)1.99034317
179diterpenoid biosynthetic process (GO:0016102)1.98597969
180drug catabolic process (GO:0042737)1.98290211
181regulation of fever generation (GO:0031620)1.97807110

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse6.40464637
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.14282622
3RXR_22158963_ChIP-Seq_LIVER_Mouse4.65634466
4* PPARA_22158963_ChIP-Seq_LIVER_Mouse3.79839719
5LXR_22158963_ChIP-Seq_LIVER_Mouse3.79290793
6GATA1_22025678_ChIP-Seq_K562_Human3.71274075
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.18378596
8POU3F2_20337985_ChIP-ChIP_501MEL_Human3.16632639
9* CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.96005865
10PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.88090062
11EGR1_23403033_ChIP-Seq_LIVER_Mouse2.79795441
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.66733023
13GBX2_23144817_ChIP-Seq_PC3_Human2.61002817
14* CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.53106990
15TAF15_26573619_Chip-Seq_HEK293_Human2.50957157
16CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.47559255
17DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.39761610
18FLI1_27457419_Chip-Seq_LIVER_Mouse2.30525155
19STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.25667193
20* CLOCK_20551151_ChIP-Seq_293T_Human2.14614089
21SMAD_19615063_ChIP-ChIP_OVARY_Human2.13010817
22SOX2_27498859_Chip-Seq_STOMACH_Mouse2.05767526
23GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.05513445
24TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.04941679
25* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.98623541
26FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.95488047
27PCGF2_27294783_Chip-Seq_ESCs_Mouse1.94731352
28P300_19829295_ChIP-Seq_ESCs_Human1.92459313
29PIAS1_25552417_ChIP-Seq_VCAP_Human1.89387329
30FUS_26573619_Chip-Seq_HEK293_Human1.89190404
31TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.88336175
32VDR_22108803_ChIP-Seq_LS180_Human1.85622919
33CDX2_19796622_ChIP-Seq_MESCs_Mouse1.84484298
34* ER_23166858_ChIP-Seq_MCF-7_Human1.81017753
35NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.80862764
36FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.80747446
37SMAD4_21799915_ChIP-Seq_A2780_Human1.80243033
38* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.76205234
39CTBP2_25329375_ChIP-Seq_LNCAP_Human1.74428034
40* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.73473911
41FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.72275449
42SUZ12_27294783_Chip-Seq_NPCs_Mouse1.70865193
43E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.69368505
44BCAT_22108803_ChIP-Seq_LS180_Human1.68894600
45FOXA1_25552417_ChIP-Seq_VCAP_Human1.66295110
46EZH2_27294783_Chip-Seq_NPCs_Mouse1.64996055
47NANOG_18555785_Chip-Seq_ESCs_Mouse1.64354723
48TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.61633922
49ESR1_21235772_ChIP-Seq_MCF-7_Human1.58230831
50PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.52351127
51IRF8_22096565_ChIP-ChIP_GC-B_Human1.52302029
52AR_25329375_ChIP-Seq_VCAP_Human1.52222033
53SALL1_21062744_ChIP-ChIP_HESCs_Human1.51682846
54NRF2_20460467_ChIP-Seq_MEFs_Mouse1.50822387
55NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.50822387
56NFE2_27457419_Chip-Seq_LIVER_Mouse1.50436073
57* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.49815881
58GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.49797162
59PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.49625197
60UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.49303114
61AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.48985804
62EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.48409367
63CTBP1_25329375_ChIP-Seq_LNCAP_Human1.44096253
64P53_22387025_ChIP-Seq_ESCs_Mouse1.42180353
65SMAD3_21741376_ChIP-Seq_EPCs_Human1.41622164
66* CBP_20019798_ChIP-Seq_JUKART_Human1.38561295
67* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.38561295
68SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.38104541
69* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.38088450
70CRX_20693478_ChIP-Seq_RETINA_Mouse1.36910541
71GABP_17652178_ChIP-ChIP_JURKAT_Human1.36411729
72STAT3_23295773_ChIP-Seq_U87_Human1.35721076
73EWS_26573619_Chip-Seq_HEK293_Human1.34804361
74NOTCH1_21737748_ChIP-Seq_TLL_Human1.34396957
75STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.33739851
76NR3C1_21868756_ChIP-Seq_MCF10A_Human1.33459482
77GATA3_27048872_Chip-Seq_THYMUS_Human1.33234247
78CMYC_18555785_Chip-Seq_ESCs_Mouse1.32981933
79SOX2_19829295_ChIP-Seq_ESCs_Human1.29500182
80NANOG_19829295_ChIP-Seq_ESCs_Human1.29500182
81ERG_20517297_ChIP-Seq_VCAP_Human1.29431261
82ZNF217_24962896_ChIP-Seq_MCF-7_Human1.29377514
83E2F1_18555785_Chip-Seq_ESCs_Mouse1.28530398
84TFEB_21752829_ChIP-Seq_HELA_Human1.26333411
85CJUN_26792858_Chip-Seq_BT549_Human1.26061392
86* KAP1_22055183_ChIP-Seq_ESCs_Mouse1.25390854
87TP53_18474530_ChIP-ChIP_U2OS_Human1.24654369
88SUZ12_18555785_Chip-Seq_ESCs_Mouse1.24631927
89GATA4_25053715_ChIP-Seq_YYC3_Human1.23540033
90HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.23334850
91STAT3_18555785_Chip-Seq_ESCs_Mouse1.23023170
92TCF4_22108803_ChIP-Seq_LS180_Human1.22786551
93FOXA1_21572438_ChIP-Seq_LNCaP_Human1.22643009
94RUNX2_22187159_ChIP-Seq_PCA_Human1.22284658
95SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.21451809
96WT1_19549856_ChIP-ChIP_CCG9911_Human1.18970581
97FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.17746894
98FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.16733549
99TAL1_26923725_Chip-Seq_HPCs_Mouse1.16708588
100EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.15670787
101* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.15545135
102* OCT4_21477851_ChIP-Seq_ESCs_Mouse1.14765569
103EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.14730288
104HIF1A_21447827_ChIP-Seq_MCF-7_Human1.14155278
105KLF5_20875108_ChIP-Seq_MESCs_Mouse1.13586979
106TCF4_23295773_ChIP-Seq_U87_Human1.13191798
107P300_18555785_Chip-Seq_ESCs_Mouse1.12534094
108SOX2_18555785_Chip-Seq_ESCs_Mouse1.11900907
109SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.10691632
110FOXA2_19822575_ChIP-Seq_HepG2_Human1.09751321
111REST_19997604_ChIP-ChIP_NEURONS_Mouse1.08651435
112OCT4_18555785_Chip-Seq_ESCs_Mouse1.07743583
113PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06500941
114* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.04982734
115SMAD4_21741376_ChIP-Seq_EPCs_Human1.04361109
116PCGF2_27294783_Chip-Seq_NPCs_Mouse1.04220527
117NR3C1_23031785_ChIP-Seq_PC12_Mouse1.03755987
118BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.03495168
119CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.03053006
120MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.02933149
121SALL4_18804426_ChIP-ChIP_XEN_Mouse1.02185499
122* SOX2_20726797_ChIP-Seq_SW620_Human1.01393863
123* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.01376693
124Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.99649865
125NMYC_18555785_Chip-Seq_ESCs_Mouse0.99464316
126GATA2_21666600_ChIP-Seq_HMVEC_Human0.99138104
127MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.99024667
128GATA3_26560356_Chip-Seq_TH2_Human0.98834845
129TP63_23658742_ChIP-Seq_EP156T_Human0.98395811
130FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.97390841
131PU1_27457419_Chip-Seq_LIVER_Mouse0.95857857
132CTCF_18555785_Chip-Seq_ESCs_Mouse0.95481117
133PRDM14_20953172_ChIP-Seq_ESCs_Human0.95444382
134RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.95303483
135NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.95072518
136PADI4_21655091_ChIP-ChIP_MCF-7_Human0.94651005
137RUNX1_27457419_Chip-Seq_LIVER_Mouse0.93696600
138SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.92794032
139* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.92343213
140SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.92173768
141ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.91764622
142FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.91076733
143GATA3_24758297_ChIP-Seq_MCF-7_Human0.89549054
144PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.89406060
145IGF1R_20145208_ChIP-Seq_DFB_Human0.89362222
146TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.88898579
147SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.87858886
148SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.85832636
149GATA1_19941826_ChIP-Seq_K562_Human0.85070286
150GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.85018966
151HTT_18923047_ChIP-ChIP_STHdh_Human0.85004582
152ELF1_17652178_ChIP-ChIP_JURKAT_Human0.84597624
153ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.84462584
154ZNF263_19887448_ChIP-Seq_K562_Human0.83665248
155RARA_24833708_ChIP-Seq_LIVER_Mouse0.83412685
156GATA3_26560356_Chip-Seq_TH1_Human0.82786963
157CDX2_22108803_ChIP-Seq_LS180_Human0.82533905
158ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.82206406
159RARB_24833708_ChIP-Seq_LIVER_Mouse0.82195799
160ERG_20887958_ChIP-Seq_HPC-7_Mouse0.81303807
161AR_20517297_ChIP-Seq_VCAP_Human0.81185937
162NFIB_24661679_ChIP-Seq_LUNG_Mouse0.80477443
163FOXH1_21741376_ChIP-Seq_ESCs_Human0.79285380
164HNF4A_19822575_ChIP-Seq_HepG2_Human0.78479653
165VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.78107964
166FOXO3_23340844_ChIP-Seq_DLD1_Human0.77898387
167BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.77589870
168GATA6_25053715_ChIP-Seq_YYC3_Human0.77435630
169* SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.77434660
170ESR2_21235772_ChIP-Seq_MCF-7_Human0.77178822
171ETS1_22383799_ChIP-Seq_G1ME_Mouse0.77029014
172* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.74233367
173* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.72970775
174E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.71568418
175GABP_19822575_ChIP-Seq_HepG2_Human0.71112861
176PKCTHETA_26484144_Chip-Seq_BREAST_Human0.70506763
177* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.69280884
178EGR1_19374776_ChIP-ChIP_THP-1_Human0.68267607
179TP53_22573176_ChIP-Seq_HFKS_Human0.67807116
180CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.67419455
181ZNF274_21170338_ChIP-Seq_K562_Hela0.67262106
182GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.67014489
183CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.66783499
184* FLI1_21867929_ChIP-Seq_TH2_Mouse0.65526538

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002877_abnormal_melanocyte_morpholog4.24536194
2MP0003195_calcinosis4.05467344
3MP0002139_abnormal_hepatobiliary_system3.90639158
4MP0005365_abnormal_bile_salt3.87967468
5MP0002693_abnormal_pancreas_physiology3.67321971
6MP0004043_abnormal_pH_regulation3.48509543
7MP0001944_abnormal_pancreas_morphology3.36778176
8MP0002909_abnormal_adrenal_gland3.35177575
9MP0000013_abnormal_adipose_tissue3.25441818
10MP0005379_endocrine/exocrine_gland_phen3.23771165
11MP0003183_abnormal_peptide_metabolism3.22007231
12MP0005220_abnormal_exocrine_pancreas3.17778248
13MP0000569_abnormal_digit_pigmentation3.16778373
14MP0003283_abnormal_digestive_organ3.03778691
15MP0009780_abnormal_chondrocyte_physiolo2.78395857
16MP0005085_abnormal_gallbladder_physiolo2.76920012
17MP0003787_abnormal_imprinting2.71046013
18MP0003252_abnormal_bile_duct2.50713485
19MP0003011_delayed_dark_adaptation2.45665241
20MP0002138_abnormal_hepatobiliary_system2.31188111
21MP0010386_abnormal_urinary_bladder2.26554683
22MP0009840_abnormal_foam_cell2.24294864
23MP0001501_abnormal_sleep_pattern2.23600017
24MP0002078_abnormal_glucose_homeostasis2.22063227
25MP0004264_abnormal_extraembryonic_tissu2.17620964
26MP0003868_abnormal_feces_composition2.16830718
27MP0000678_abnormal_parathyroid_gland2.08513824
28MP0001984_abnormal_olfaction2.07497687
29MP0006082_CNS_inflammation1.94264688
30MP0001666_abnormal_nutrient_absorption1.94020775
31MP0002837_dystrophic_cardiac_calcinosis1.93725075
32MP0005360_urolithiasis1.92493316
33MP0003880_abnormal_central_pattern1.92434604
34MP0009643_abnormal_urine_homeostasis1.89586488
35MP0002102_abnormal_ear_morphology1.86680729
36MP0008875_abnormal_xenobiotic_pharmacok1.82495690
37MP0008877_abnormal_DNA_methylation1.80771282
38MP0002928_abnormal_bile_duct1.69641672
39MP0005058_abnormal_lysosome_morphology1.67290274
40MP0000003_abnormal_adipose_tissue1.65692781
41MP0009046_muscle_twitch1.65663303
42MP0001765_abnormal_ion_homeostasis1.59865444
43MP0005646_abnormal_pituitary_gland1.59068497
44MP0003300_gastrointestinal_ulcer1.55083930
45MP0001756_abnormal_urination1.51685517
46MP0002090_abnormal_vision1.49231677
47MP0005636_abnormal_mineral_homeostasis1.48451314
48MP0010678_abnormal_skin_adnexa1.47813488
49MP0000609_abnormal_liver_physiology1.45109369
50MP0010329_abnormal_lipoprotein_level1.42839179
51MP0002332_abnormal_exercise_endurance1.42322437
52MP0002118_abnormal_lipid_homeostasis1.38873972
53MP0003953_abnormal_hormone_level1.37187875
54MP0005332_abnormal_amino_acid1.36844336
55MP0000613_abnormal_salivary_gland1.33733436
56MP0003221_abnormal_cardiomyocyte_apopto1.33002487
57MP0002896_abnormal_bone_mineralization1.32717420
58MP0005253_abnormal_eye_physiology1.27653686
59MP0004215_abnormal_myocardial_fiber1.27616855
60MP0003950_abnormal_plasma_membrane1.27368365
61MP0005551_abnormal_eye_electrophysiolog1.27163536
62MP0004924_abnormal_behavior1.26585867
63MP0005386_behavior/neurological_phenoty1.26585867
64MP0005310_abnormal_salivary_gland1.26312483
65MP0002163_abnormal_gland_morphology1.25204243
66MP0002638_abnormal_pupillary_reflex1.23534351
67MP0006054_spinal_hemorrhage1.22297547
68MP0001986_abnormal_taste_sensitivity1.21634068
69MP0001661_extended_life_span1.19322095
70MP0000462_abnormal_digestive_system1.18897408
71MP0005535_abnormal_body_temperature1.18441867
72MP0002822_catalepsy1.17740256
73MP0001764_abnormal_homeostasis1.15996405
74MP0002876_abnormal_thyroid_physiology1.13283820
75MP0003806_abnormal_nucleotide_metabolis1.11345166
76MP0006276_abnormal_autonomic_nervous1.11260420
77MP0005167_abnormal_blood-brain_barrier1.10970741
78MP0004019_abnormal_vitamin_homeostasis1.09988406
79MP0005084_abnormal_gallbladder_morpholo1.09829232
80MP0003172_abnormal_lysosome_physiology1.09087254
81MP0009785_altered_susceptibility_to1.08703786
82MP0004484_altered_response_of1.07233562
83MP0001529_abnormal_vocalization1.07157426
84MP0005319_abnormal_enzyme/_coenzyme1.06623025
85MP0001879_abnormal_lymphatic_vessel1.06099616
86MP0002009_preneoplasia1.05501565
87MP0003633_abnormal_nervous_system1.01724344
88MP0005670_abnormal_white_adipose1.01319372
89MP0005083_abnormal_biliary_tract1.00326043
90MP0000516_abnormal_urinary_system0.96261877
91MP0005367_renal/urinary_system_phenotyp0.96261877
92MP0000639_abnormal_adrenal_gland0.96007659
93MP0004085_abnormal_heartbeat0.95911537
94MP0002148_abnormal_hypersensitivity_rea0.94456125
95MP0008961_abnormal_basal_metabolism0.94347628
96MP0000230_abnormal_systemic_arterial0.94241779
97MP0008004_abnormal_stomach_pH0.93716161
98MP0000604_amyloidosis0.93255447
99MP0009642_abnormal_blood_homeostasis0.91651238
100MP0002295_abnormal_pulmonary_circulatio0.90270947
101MP0000372_irregular_coat_pigmentation0.88320383
102MP0009745_abnormal_behavioral_response0.87846417
103MP0003191_abnormal_cellular_cholesterol0.87832262
104MP0005645_abnormal_hypothalamus_physiol0.87656812
105MP0003890_abnormal_embryonic-extraembry0.86638368
106MP0004510_myositis0.86600621
107MP0005375_adipose_tissue_phenotype0.86565329
108MP0004782_abnormal_surfactant_physiolog0.86287311
109MP0002234_abnormal_pharynx_morphology0.85739081
110MP0005334_abnormal_fat_pad0.85356415
111MP0005164_abnormal_response_to0.84930273
112MP0005408_hypopigmentation0.84778211
113MP0004270_analgesia0.84348513
114MP0001486_abnormal_startle_reflex0.84228414
115MP0000383_abnormal_hair_follicle0.83772745
116MP0001270_distended_abdomen0.82838714
117MP0000427_abnormal_hair_cycle0.82684967
118MP0001502_abnormal_circadian_rhythm0.82297728
119MP0009764_decreased_sensitivity_to0.82079916
120MP0005448_abnormal_energy_balance0.79543571
121MP0004885_abnormal_endolymph0.79518159
122MP0000465_gastrointestinal_hemorrhage0.77610991
123MP0003795_abnormal_bone_structure0.77238853
124MP0002272_abnormal_nervous_system0.76220354
125MP0005376_homeostasis/metabolism_phenot0.74186548
126MP0000538_abnormal_urinary_bladder0.73493366
127MP0000598_abnormal_liver_morphology0.73392075
128MP0005266_abnormal_metabolism0.73365444
129MP0002735_abnormal_chemical_nociception0.73134167
130MP0000647_abnormal_sebaceous_gland0.72936689
131MP0005410_abnormal_fertilization0.70034730
132MP0009672_abnormal_birth_weight0.69130936
133MP0003724_increased_susceptibility_to0.68757494
134MP0000681_abnormal_thyroid_gland0.68613474
135MP0008469_abnormal_protein_level0.67887798
136MP0003959_abnormal_lean_body0.67470261
137MP0005187_abnormal_penis_morphology0.66030832
138MP0003943_abnormal_hepatobiliary_system0.64491496
139MP0003866_abnormal_defecation0.62571199
140MP0003186_abnormal_redox_activity0.59884957
141MP0010234_abnormal_vibrissa_follicle0.59126874
142MP0006072_abnormal_retinal_apoptosis0.58709475
143MP0001845_abnormal_inflammatory_respons0.53642253
144MP0001533_abnormal_skeleton_physiology0.53357233
145MP0005257_abnormal_intraocular_pressure0.53334640
146MP0006036_abnormal_mitochondrial_physio0.51709767
147MP0002136_abnormal_kidney_physiology0.51008569
148MP0010368_abnormal_lymphatic_system0.49205697
149MP0002254_reproductive_system_inflammat0.47906771
150MP0003693_abnormal_embryo_hatching0.45531030
151MP0005076_abnormal_cell_differentiation0.45172094
152MP0003436_decreased_susceptibility_to0.45052516
153MP0003656_abnormal_erythrocyte_physiolo0.43225695
154MP0001881_abnormal_mammary_gland0.42328421

Predicted human phenotypes

RankGene SetZ-score
1Hyperinsulinemic hypoglycemia (HP:0000825)6.85551661
2Hypoglycemic seizures (HP:0002173)6.52628254
3Hypoglycemic coma (HP:0001325)6.52570417
4Symptomatic seizures (HP:0011145)5.85803120
5Hyperglycemia (HP:0003074)5.14063412
6Insulin-resistant diabetes mellitus (HP:0000831)4.91718680
7Elevated circulating parathyroid hormone (PTH) level (HP:0003165)4.70305426
8Abnormality of aromatic amino acid family metabolism (HP:0004338)4.64164142
9Abnormality of the intrinsic pathway (HP:0010989)4.51610022
10Ketoacidosis (HP:0001993)4.15082478
11Abnormality of endocrine pancreas physiology (HP:0012093)3.95233335
12Abnormality of the pancreatic islet cells (HP:0006476)3.95233335
13Gout (HP:0001997)3.80096913
14Dysostosis multiplex (HP:0000943)3.77831542
15Metaphyseal dysplasia (HP:0100255)3.76544829
16Late onset (HP:0003584)3.72554899
17Mucopolysacchariduria (HP:0008155)3.72513585
18Urinary glycosaminoglycan excretion (HP:0003541)3.72513585
19Generalized aminoaciduria (HP:0002909)3.71650793
20Pancreatic islet-cell hyperplasia (HP:0004510)3.56158309
21Medial flaring of the eyebrow (HP:0010747)3.54614873
22Abnormality of polysaccharide metabolism (HP:0011012)3.45819136
23Abnormality of glycosaminoglycan metabolism (HP:0004371)3.45819136
24Abnormality of mucopolysaccharide metabolism (HP:0011020)3.45819136
25Conjugated hyperbilirubinemia (HP:0002908)3.41249730
26Abnormality of the common coagulation pathway (HP:0010990)3.40362426
27Abnormal pancreas size (HP:0012094)3.34906789
28Intrahepatic cholestasis (HP:0001406)3.25163420
29Abnormality of calcium-phosphate metabolism (HP:0100530)3.16849335
30Ketosis (HP:0001946)3.14288829
31Large for gestational age (HP:0001520)3.10637678
32Insulin resistance (HP:0000855)3.07802689
33Gait imbalance (HP:0002141)3.05298676
34Congenital primary aphakia (HP:0007707)3.04523478
35Thoracolumbar scoliosis (HP:0002944)2.97795271
36Febrile seizures (HP:0002373)2.97154848
37Nephrogenic diabetes insipidus (HP:0009806)2.96669687
38Epidermoid cyst (HP:0200040)2.93910993
39Decreased circulating renin level (HP:0003351)2.89535822
40Abnormality of purine metabolism (HP:0004352)2.87654437
41Degeneration of the lateral corticospinal tracts (HP:0002314)2.86219383
42Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.86219383
43Absent speech (HP:0001344)2.84292945
44Hyperglycinemia (HP:0002154)2.74142770
45Abnormality of monocarboxylic acid metabolism (HP:0010996)2.71755887
46Methylmalonic acidemia (HP:0002912)2.67660876
47Prolonged partial thromboplastin time (HP:0003645)2.55527602
48Hyperglycinuria (HP:0003108)2.52604157
49Xanthomatosis (HP:0000991)2.50905249
50Hypokalemia (HP:0002900)2.45578795
51Neonatal respiratory distress (HP:0002643)2.43488048
52Steatorrhea (HP:0002570)2.43364152
53Stomatitis (HP:0010280)2.41339851
54Progressive neurologic deterioration (HP:0002344)2.40475689
55Protuberant abdomen (HP:0001538)2.40064346
56Retinal atrophy (HP:0001105)2.39500305
57Genital tract atresia (HP:0001827)2.30828603
58Agitation (HP:0000713)2.28819090
59Abdominal distention (HP:0003270)2.28360177
60Intestinal atresia (HP:0011100)2.27046010
61Chronic bronchitis (HP:0004469)2.25704946
62Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.25362563
63Methylmalonic aciduria (HP:0012120)2.23301990
64Abnormality of vitamin B metabolism (HP:0004340)2.21145711
65Fat malabsorption (HP:0002630)2.21017177
66Irritability (HP:0000737)2.20096430
67Hypokinesia (HP:0002375)2.19598275
68Limb hypertonia (HP:0002509)2.19331263
69Hyperphosphatemia (HP:0002905)2.19028271
70Skin nodule (HP:0200036)2.16973683
71Albinism (HP:0001022)2.16565631
72Double outlet right ventricle (HP:0001719)2.16296856
73Congenital malformation of the right heart (HP:0011723)2.16296856
74Hematochezia (HP:0002573)2.16169231
75Polyphagia (HP:0002591)2.15909139
76Vacuolated lymphocytes (HP:0001922)2.15853799
77Vaginal atresia (HP:0000148)2.14832597
78Hyperkalemia (HP:0002153)2.14106981
79Restlessness (HP:0000711)2.13779491
80Hyperuricemia (HP:0002149)2.12943503
81Increased purine levels (HP:0004368)2.12943503
82Thyroid carcinoma (HP:0002890)2.12917098
83Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.11700271
84Abnormal protein N-linked glycosylation (HP:0012347)2.11700271
85Abnormal protein glycosylation (HP:0012346)2.11700271
86Abnormal glycosylation (HP:0012345)2.11700271
87Type I diabetes mellitus (HP:0100651)2.11333492
88Hyperactive renin-angiotensin system (HP:0000841)2.10599250
89Complement deficiency (HP:0004431)2.05506148
90Dysautonomia (HP:0002459)2.04637103
91Exocrine pancreatic insufficiency (HP:0001738)2.04113486
92Abnormality of potassium homeostasis (HP:0011042)2.03862735
93Prominent metopic ridge (HP:0005487)2.03461844
94Hypothermia (HP:0002045)2.03403664
95Abnormality of renin-angiotensin system (HP:0000847)2.02920514
96EEG with generalized epileptiform discharges (HP:0011198)2.02801467
97Osteomalacia (HP:0002749)2.02785880
98Unilateral renal agenesis (HP:0000122)2.02417042
99Hypsarrhythmia (HP:0002521)2.02360800
100Amyotrophic lateral sclerosis (HP:0007354)2.01017195
101Abnormality of liposaccharide metabolism (HP:0010968)2.00830985
102Abnormality of glycosphingolipid metabolism (HP:0004343)2.00830985
103Abnormality of glycolipid metabolism (HP:0010969)2.00830985
104Acute hepatic failure (HP:0006554)2.00626893
105Irregular vertebral endplates (HP:0003301)2.00331635
106Abnormality of vitamin metabolism (HP:0100508)1.99971630
107Abnormality of the vitamin B12 metabolism (HP:0004341)1.99588008
108Hydroxyprolinuria (HP:0003080)1.99555767
109Abnormality of proline metabolism (HP:0010907)1.99555767
110Abnormality of alkaline phosphatase activity (HP:0004379)1.99555484
111Abnormality of midbrain morphology (HP:0002418)1.98960307
112Molar tooth sign on MRI (HP:0002419)1.98960307
113Elevated alkaline phosphatase (HP:0003155)1.98780575
114Abnormal enzyme/coenzyme activity (HP:0012379)1.98759436
115Glucose intolerance (HP:0000833)1.98193636
116Abnormality of glycine metabolism (HP:0010895)1.97106589
117Abnormality of serine family amino acid metabolism (HP:0010894)1.97106589
118Joint swelling (HP:0001386)1.96394973
119Epileptiform EEG discharges (HP:0011182)1.95682912
120Papillary thyroid carcinoma (HP:0002895)1.95601757
121Tetraparesis (HP:0002273)1.95436209
122Abnormality of the corticospinal tract (HP:0002492)1.91578135
123Hyperventilation (HP:0002883)1.91236649
124Abnormality of nucleobase metabolism (HP:0010932)1.89492501
125Pancreatic cysts (HP:0001737)1.89431034
126Abnormality of chloride homeostasis (HP:0011422)1.86818979
127Poor coordination (HP:0002370)1.86749038
128Hyperbilirubinemia (HP:0002904)1.86090972
129Abnormality of methionine metabolism (HP:0010901)1.85640363
130Gaze-evoked nystagmus (HP:0000640)1.83315271
131Progressive muscle weakness (HP:0003323)1.81865293
132Metaphyseal irregularity (HP:0003025)1.81296093
133Abnormality of fatty-acid metabolism (HP:0004359)1.80999513
134Hypomagnesemia (HP:0002917)1.80547594
135Abnormality of aspartate family amino acid metabolism (HP:0010899)1.79916218
136Global brain atrophy (HP:0002283)1.79764401
137Palpitations (HP:0001962)1.78776282
138Muscular hypotonia of the trunk (HP:0008936)1.78504846
139Pancreatitis (HP:0001733)1.77813780
140True hermaphroditism (HP:0010459)1.75513856
141Generalized myoclonic seizures (HP:0002123)1.75152587
142Pancreatic fibrosis (HP:0100732)1.74199468
143Abnormality of glutamine family amino acid metabolism (HP:0010902)1.74136358
144Nephronophthisis (HP:0000090)1.73095120
145Beaking of vertebral bodies (HP:0004568)1.72846931
146Deep venous thrombosis (HP:0002625)1.72607973
147Glycosuria (HP:0003076)1.72130065
148Abnormality of urine glucose concentration (HP:0011016)1.72130065
149Thyroiditis (HP:0100646)1.71884328
150Flat capital femoral epiphysis (HP:0003370)1.71436942
151Hypophosphatemia (HP:0002148)1.71036933
152Abnormal tarsal ossification (HP:0008369)1.70207258
153Aplasia/Hypoplasia of the fovea (HP:0008060)1.69906918
154Hypoplasia of the fovea (HP:0007750)1.69906918
155Polycythemia (HP:0001901)1.69669835
156Severe short stature (HP:0003510)1.69477857
157Fair hair (HP:0002286)1.68801597
158Atrophy/Degeneration involving motor neurons (HP:0007373)1.68116568
159Increased circulating renin level (HP:0000848)1.66605199
160Dyskinesia (HP:0100660)1.65554749
161Disinhibition (HP:0000734)1.63552925
162Decreased testicular size (HP:0008734)1.62535474
163Failure to thrive in infancy (HP:0001531)1.62304038
164Intellectual disability, progressive (HP:0006887)1.62226061
165Widely spaced teeth (HP:0000687)1.62072739
166Tongue fasciculations (HP:0001308)1.61294612
167Termporal pattern (HP:0011008)1.60361162
168Insidious onset (HP:0003587)1.60361162

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR6.33692201
2TAOK34.71535565
3MAP4K24.50124320
4ERN14.28585792
5MAPK154.10455447
6PASK4.06261794
7FRK3.89418868
8BCR3.22239396
9IRAK32.74195845
10CASK2.62847369
11MAP3K42.57122743
12FLT32.53842521
13HIPK22.47789737
14MAP3K22.29476604
15PRKD32.27509727
16MST42.19230798
17BRSK22.17292400
18MAP2K72.13973245
19BCKDK2.09166601
20TRIM282.07402831
21AKT31.89001861
22EIF2AK31.78573475
23MAP3K31.62687494
24LATS11.54528958
25SCYL21.52158989
26MAP3K11.50891508
27DAPK21.49972718
28IRAK11.49003020
29EPHA31.41919479
30SIK31.39926057
31CAMKK21.37755326
32WNK41.36931713
33MAPK131.36422107
34ADRBK21.35385987
35BMPR21.28360465
36GRK11.27067302
37MAP3K121.26335287
38PIK3CG1.26002985
39NTRK11.15462070
40PLK21.15417612
41WNK31.12753424
42NLK1.11672915
43ACVR1B1.10944097
44STK38L1.09138728
45CSNK1G21.00404517
46PTK61.00380238
47PHKG20.97761404
48PHKG10.97761404
49JAK20.96106268
50DYRK30.96050122
51PDGFRA0.95514143
52TGFBR20.95411128
53TRPM70.94777507
54CSNK1G10.94659809
55DYRK1B0.94136304
56TXK0.93195014
57MARK10.93080781
58FGFR40.90977647
59CSNK1G30.90546568
60PTK20.90046092
61TIE10.89096413
62MAP2K20.88675726
63PRKAA10.87757978
64JAK30.86782882
65STK390.83730002
66MET0.83389634
67DYRK1A0.82430382
68PIK3CA0.81493451
69PAK30.79981012
70ZAP700.78011528
71TRIB30.77411271
72IKBKB0.76655081
73IRAK40.75700823
74CSNK1A1L0.71068878
75STK30.70168130
76CAMK2A0.68372335
77GRK70.67757938
78PKN10.67669575
79IRAK20.66716574
80JAK10.65146860
81TEC0.64250881
82PRKCH0.63286427
83NTRK30.62774144
84CDC42BPA0.62759819
85OXSR10.62718332
86CHUK0.60827253
87PINK10.60455665
88BRSK10.60370523
89CAMK2D0.58263898
90LIMK10.57728835
91ERBB40.57479436
92TYK20.56657688
93TNIK0.56035478
94SIK10.55368514
95MATK0.55219704
96PIM20.54450150
97PRKAA20.54402432
98TESK10.54397729
99GSK3A0.54088649
100PRKCG0.54027659
101EPHA40.51859302
102PRKD20.51695027
103OBSCN0.50760446
104MAP3K60.49342782
105MYLK0.49310086
106ARAF0.47979364
107MAPKAPK30.47585911
108EGFR0.46554404
109MAP2K40.45634887
110PRKCQ0.44764153
111EPHA20.43901604
112MAP3K90.43492739
113NUAK10.43254024
114MAP3K140.42896500
115TBK10.42549364
116KSR20.42209131
117BRAF0.41158029
118CAMKK10.41101296
119ADRBK10.39690833
120FGFR30.39337895
121STK240.38672987
122MAPK70.38359194
123CAMK2B0.38281784
124ABL10.38261282
125UHMK10.36452057
126PRKACG0.35914784
127IGF1R0.34646152
128PRKG10.34639972
129RPS6KA40.34394683
130PRKACA0.34011296
131RET0.33805650
132TAF10.33327407
133NEK90.33083799
134MARK30.32358163
135CDK50.31923467
136MAP3K50.31422586
137ITK0.30992199
138STK160.29410621
139PDGFRB0.29159300
140ERBB30.28926447
141PRKCE0.27572325
142TAOK10.27220734
143NEK60.26455192
144MAPK110.25670207
145MTOR0.25170666
146FER0.24557747
147MAP2K30.24309859
148SGK20.24044819
149MAP2K10.23547413
150PRKD10.23247170
151PDK20.23163470
152PRKG20.22399791
153PRKCI0.22371886
154RPS6KB10.22361987
155CSNK1A10.21487805
156BMPR1B0.20586932
157EPHB10.19534218
158IKBKE0.18522690

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049508.00501370
2Protein export_Homo sapiens_hsa030605.29630325
3Sulfur metabolism_Homo sapiens_hsa009203.38689001
4Protein processing in endoplasmic reticulum_Homo sapiens_hsa041413.36937920
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.87597668
6Folate biosynthesis_Homo sapiens_hsa007902.31170542
7Selenocompound metabolism_Homo sapiens_hsa004502.27180532
8Insulin secretion_Homo sapiens_hsa049112.03019435
9Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.85427939
10Primary bile acid biosynthesis_Homo sapiens_hsa001201.72493963
11Tryptophan metabolism_Homo sapiens_hsa003801.71519367
12Collecting duct acid secretion_Homo sapiens_hsa049661.69174929
13Lysosome_Homo sapiens_hsa041421.61854845
14Regulation of autophagy_Homo sapiens_hsa041401.61683292
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.56976895
16Vitamin B6 metabolism_Homo sapiens_hsa007501.55463392
17N-Glycan biosynthesis_Homo sapiens_hsa005101.53115802
18Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.52928626
19Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.50509578
20Type I diabetes mellitus_Homo sapiens_hsa049401.49796718
21Glycosaminoglycan degradation_Homo sapiens_hsa005311.49645410
22Type II diabetes mellitus_Homo sapiens_hsa049301.44169954
23Butanoate metabolism_Homo sapiens_hsa006501.44114845
24Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.37576204
25Nitrogen metabolism_Homo sapiens_hsa009101.35861109
26Carbohydrate digestion and absorption_Homo sapiens_hsa049731.33772223
27Rheumatoid arthritis_Homo sapiens_hsa053231.33421230
28Circadian rhythm_Homo sapiens_hsa047101.27692698
29Other glycan degradation_Homo sapiens_hsa005111.27482753
30Phototransduction_Homo sapiens_hsa047441.21335345
31Starch and sucrose metabolism_Homo sapiens_hsa005001.19381133
32Fatty acid degradation_Homo sapiens_hsa000711.18851026
33ABC transporters_Homo sapiens_hsa020101.15145412
34Mineral absorption_Homo sapiens_hsa049781.14455252
35Pentose and glucuronate interconversions_Homo sapiens_hsa000401.13233161
36Steroid biosynthesis_Homo sapiens_hsa001001.12191533
37Insulin resistance_Homo sapiens_hsa049311.09350993
38Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.08217422
39Vibrio cholerae infection_Homo sapiens_hsa051101.06742861
40Histidine metabolism_Homo sapiens_hsa003401.05664745
41Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.03974636
42Complement and coagulation cascades_Homo sapiens_hsa046101.02910724
43Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.02798411
44Drug metabolism - other enzymes_Homo sapiens_hsa009831.01462407
45Fat digestion and absorption_Homo sapiens_hsa049751.00644438
46Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.00018128
47Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.95427527
48Prion diseases_Homo sapiens_hsa050200.93972243
49Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.93324596
50Peroxisome_Homo sapiens_hsa041460.91035078
51GABAergic synapse_Homo sapiens_hsa047270.87980719
52Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.87907589
53Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.87444492
54Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.87016398
55Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.86714608
56SNARE interactions in vesicular transport_Homo sapiens_hsa041300.84899081
57Vitamin digestion and absorption_Homo sapiens_hsa049770.84728466
58Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.83340177
59Galactose metabolism_Homo sapiens_hsa000520.80341447
60Cocaine addiction_Homo sapiens_hsa050300.79793821
61Phenylalanine metabolism_Homo sapiens_hsa003600.79684559
62Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.79269828
63Glucagon signaling pathway_Homo sapiens_hsa049220.79113686
64Linoleic acid metabolism_Homo sapiens_hsa005910.77820360
65Pertussis_Homo sapiens_hsa051330.77696863
66Ether lipid metabolism_Homo sapiens_hsa005650.76838714
67NOD-like receptor signaling pathway_Homo sapiens_hsa046210.76624719
68Pancreatic secretion_Homo sapiens_hsa049720.76159255
69Thyroid hormone synthesis_Homo sapiens_hsa049180.75534550
70Arginine biosynthesis_Homo sapiens_hsa002200.75412223
71alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.73574716
72Nicotine addiction_Homo sapiens_hsa050330.72671244
73Sphingolipid metabolism_Homo sapiens_hsa006000.70906670
74Prolactin signaling pathway_Homo sapiens_hsa049170.67877175
75Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.67871362
76Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.66394185
77beta-Alanine metabolism_Homo sapiens_hsa004100.63860749
78Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.62316060
79African trypanosomiasis_Homo sapiens_hsa051430.60035347
80Fatty acid metabolism_Homo sapiens_hsa012120.59645009
81Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.59255772
82Propanoate metabolism_Homo sapiens_hsa006400.58715241
83Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.58447256
84Legionellosis_Homo sapiens_hsa051340.56937857
85Glycerophospholipid metabolism_Homo sapiens_hsa005640.56893068
86Antigen processing and presentation_Homo sapiens_hsa046120.56787690
87Arginine and proline metabolism_Homo sapiens_hsa003300.56105902
88Arachidonic acid metabolism_Homo sapiens_hsa005900.55968269
89Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.55843214
90Basal transcription factors_Homo sapiens_hsa030220.55690154
91Bile secretion_Homo sapiens_hsa049760.54855671
92PPAR signaling pathway_Homo sapiens_hsa033200.52379621
93Serotonergic synapse_Homo sapiens_hsa047260.51940962
94TNF signaling pathway_Homo sapiens_hsa046680.51053463
95Tyrosine metabolism_Homo sapiens_hsa003500.50121210
96Dopaminergic synapse_Homo sapiens_hsa047280.48960986
97Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.48703325
98Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.48148495
99Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.47258092
100RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.46111613
101Renin secretion_Homo sapiens_hsa049240.46021128
102Longevity regulating pathway - mammal_Homo sapiens_hsa042110.45297296
103Taste transduction_Homo sapiens_hsa047420.44621454
104Caffeine metabolism_Homo sapiens_hsa002320.44390175
105Steroid hormone biosynthesis_Homo sapiens_hsa001400.43037521
106Ovarian steroidogenesis_Homo sapiens_hsa049130.42820058
107Staphylococcus aureus infection_Homo sapiens_hsa051500.41505020
108Adipocytokine signaling pathway_Homo sapiens_hsa049200.40724430
109Synaptic vesicle cycle_Homo sapiens_hsa047210.40613791
110Chemical carcinogenesis_Homo sapiens_hsa052040.38779105
111Morphine addiction_Homo sapiens_hsa050320.38115017
112Protein digestion and absorption_Homo sapiens_hsa049740.36816261
113Fructose and mannose metabolism_Homo sapiens_hsa000510.35975643
114Sulfur relay system_Homo sapiens_hsa041220.35920700
115Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.35337793
116Pentose phosphate pathway_Homo sapiens_hsa000300.33377449
117Fatty acid elongation_Homo sapiens_hsa000620.32989265
118Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.32667682
119Renin-angiotensin system_Homo sapiens_hsa046140.31059593
120Insulin signaling pathway_Homo sapiens_hsa049100.30587537
121Lysine degradation_Homo sapiens_hsa003100.30332853
122AMPK signaling pathway_Homo sapiens_hsa041520.28949585
123Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.28193124
124Prostate cancer_Homo sapiens_hsa052150.27138647
125Amphetamine addiction_Homo sapiens_hsa050310.26872112
126Retinol metabolism_Homo sapiens_hsa008300.25589388
127Metabolic pathways_Homo sapiens_hsa011000.25307689
128Thyroid cancer_Homo sapiens_hsa052160.25148672
129FoxO signaling pathway_Homo sapiens_hsa040680.24855692
130Cysteine and methionine metabolism_Homo sapiens_hsa002700.24759616
131Glycerolipid metabolism_Homo sapiens_hsa005610.23047852
132mTOR signaling pathway_Homo sapiens_hsa041500.20076363
133Dorso-ventral axis formation_Homo sapiens_hsa043200.19105129
134Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.17853907

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