DNAJC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The membrane protein encoded by this gene is a DNAJ-like heat shock protein that binds the molecular chaperone BiP. In addition, the encoded protein contains two SANT domains that have been shown to bind serpin alpha1-antichymotrypsin and inter-alpha trypsin inhibitor heavy chain 4. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.80711032
2viral transcription (GO:0019083)4.26009837
3ribosomal small subunit assembly (GO:0000028)4.22798307
4autophagic vacuole fusion (GO:0000046)4.18418776
5ribosomal small subunit biogenesis (GO:0042274)4.15923179
6translational termination (GO:0006415)4.08350671
7SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.06800337
8protein targeting to ER (GO:0045047)3.99644564
9cotranslational protein targeting to membrane (GO:0006613)3.96597561
10deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.96361033
11protein localization to endoplasmic reticulum (GO:0070972)3.88977650
12establishment of protein localization to endoplasmic reticulum (GO:0072599)3.86200931
13pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.53329418
14organelle membrane fusion (GO:0090174)3.51615162
15COPI coating of Golgi vesicle (GO:0048205)3.49152000
16Golgi transport vesicle coating (GO:0048200)3.49152000
17mitochondrial calcium ion transport (GO:0006851)3.47750639
18pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.43203866
19maturation of SSU-rRNA (GO:0030490)3.36396084
20translational elongation (GO:0006414)3.35278712
21viral life cycle (GO:0019058)3.30208198
22G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.29459108
23ribosomal large subunit biogenesis (GO:0042273)3.28480586
24protein maturation by protein folding (GO:0022417)3.27891200
25positive regulation of natural killer cell differentiation (GO:0032825)3.20212742
26positive regulation of gamma-delta T cell activation (GO:0046645)3.19169845
27nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.12848909
28translational initiation (GO:0006413)3.03842638
29erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.01066934
30L-phenylalanine metabolic process (GO:0006558)3.01066934
31deoxyribose phosphate biosynthetic process (GO:0046385)3.00023052
322-deoxyribonucleotide biosynthetic process (GO:0009265)3.00023052
33pyrimidine nucleotide catabolic process (GO:0006244)2.97018212
34cellular protein complex disassembly (GO:0043624)2.96414410
35positive regulation of cellular amide metabolic process (GO:0034250)2.95173552
36imidazole-containing compound metabolic process (GO:0052803)2.94501273
37protein retention in ER lumen (GO:0006621)2.94415147
38positive regulation of heat generation (GO:0031652)2.90060263
39maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.80996749
40nucleotide salvage (GO:0043173)2.80653454
41xenobiotic catabolic process (GO:0042178)2.79261690
42hyaluronan catabolic process (GO:0030214)2.78656651
43T cell apoptotic process (GO:0070231)2.78424014
44antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.77835257
45antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.77835257
46NIK/NF-kappaB signaling (GO:0038061)2.75550521
47T-helper cell differentiation (GO:0042093)2.74124303
48CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.74124303
49regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.73976316
50translation (GO:0006412)2.70579192
51superoxide anion generation (GO:0042554)2.68956064
52deoxyribonucleotide catabolic process (GO:0009264)2.68795995
53response to peptidoglycan (GO:0032494)2.68299131
54ribonucleoprotein complex biogenesis (GO:0022613)2.67372361
55protein targeting to membrane (GO:0006612)2.66593336
56negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.66576995
57negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.65828864
58macrophage activation involved in immune response (GO:0002281)2.65767107
59positive regulation by symbiont of host defense response (GO:0052509)2.65508259
60modulation by symbiont of host defense response (GO:0052031)2.65508259
61modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.65508259
62modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.65508259
63positive regulation by organism of defense response of other organism involved in symbiotic interact2.65508259
64modulation by symbiont of host immune response (GO:0052553)2.65508259
65positive regulation of T cell mediated cytotoxicity (GO:0001916)2.65205558
66histone H3-K4 trimethylation (GO:0080182)2.64519412
67phosphatidylglycerol biosynthetic process (GO:0006655)2.64396861
68positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.63682804
69pyrimidine-containing compound salvage (GO:0008655)2.61464651
70pyrimidine nucleoside salvage (GO:0043097)2.61464651
71deoxyribose phosphate catabolic process (GO:0046386)2.61008058
72microglial cell activation (GO:0001774)2.60456917
73lymphocyte apoptotic process (GO:0070227)2.57380084
74negative regulation of DNA-templated transcription, elongation (GO:0032785)2.55937020
75telomere maintenance via semi-conservative replication (GO:0032201)2.51712925
76polyketide metabolic process (GO:0030638)2.51622015
77doxorubicin metabolic process (GO:0044598)2.51622015
78daunorubicin metabolic process (GO:0044597)2.51622015
79deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.51146871
80response to muramyl dipeptide (GO:0032495)2.49965095
81regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.49939435
82formation of translation preinitiation complex (GO:0001731)2.49848441
83aerobic respiration (GO:0009060)2.49826847
84regulation of heat generation (GO:0031650)2.49732174
85protein complex disassembly (GO:0043241)2.48715894
86pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.48382596
87negative regulation of myeloid cell apoptotic process (GO:0033033)2.47998858
88detection of other organism (GO:0098543)2.47997379
89exocrine pancreas development (GO:0031017)2.45743745
90lipopolysaccharide-mediated signaling pathway (GO:0031663)2.44098262
91proteasome assembly (GO:0043248)2.43257109
92glycolipid catabolic process (GO:0019377)2.42754065
93glycosphingolipid catabolic process (GO:0046479)2.42062036
94detection of molecule of bacterial origin (GO:0032490)2.41347836
95positive regulation of interferon-alpha production (GO:0032727)2.41335701
96establishment of protein localization to mitochondrial membrane (GO:0090151)2.40365683
97negative regulation of lipid storage (GO:0010888)2.40314277
98regulation of fever generation (GO:0031620)2.38595036
99regulation of interferon-alpha production (GO:0032647)2.38591738
100deoxyribonucleotide biosynthetic process (GO:0009263)2.38440366
101definitive hemopoiesis (GO:0060216)2.37779346
102regulation of interferon-beta biosynthetic process (GO:0045357)2.37623328
103neutrophil activation involved in immune response (GO:0002283)2.37120375
104response to type I interferon (GO:0034340)2.37015749
105interleukin-1-mediated signaling pathway (GO:0070498)2.36814722
106CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.36290623
107positive regulation of triglyceride lipase activity (GO:0061365)2.36083590
108positive regulation of lipoprotein lipase activity (GO:0051006)2.36083590
109macromolecular complex disassembly (GO:0032984)2.35402152
110endosome to melanosome transport (GO:0035646)2.34401444
111endosome to pigment granule transport (GO:0043485)2.34401444
112positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.34105993
113antigen processing and presentation of endogenous antigen (GO:0019883)2.33742547
114ceramide catabolic process (GO:0046514)2.32606259
115oligosaccharide catabolic process (GO:0009313)2.32306205
116negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.31626769
117leukocyte apoptotic process (GO:0071887)2.31593448
118germinal center formation (GO:0002467)2.31573177
119regulation of T cell tolerance induction (GO:0002664)2.31534849
120mature B cell differentiation involved in immune response (GO:0002313)2.31459244
121mitotic recombination (GO:0006312)2.31330863
122purinergic nucleotide receptor signaling pathway (GO:0035590)2.30975431
123type I interferon signaling pathway (GO:0060337)2.30966192
124cellular response to type I interferon (GO:0071357)2.30966192
125mesenchymal-epithelial cell signaling (GO:0060638)2.30286480
126telomere maintenance via recombination (GO:0000722)2.30144146
127detection of bacterium (GO:0016045)2.30140349
128pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.29695949
129negative regulation of granulocyte differentiation (GO:0030853)2.29623705
130positive regulation of smooth muscle cell migration (GO:0014911)2.28938342
131regulation of interleukin-12 biosynthetic process (GO:0045075)2.28895788
132interferon-gamma production (GO:0032609)2.28019588
133regulation of activation of Janus kinase activity (GO:0010533)2.27346987
134alpha-beta T cell differentiation involved in immune response (GO:0002293)2.27208494
135alpha-beta T cell activation involved in immune response (GO:0002287)2.27208494
136T cell differentiation involved in immune response (GO:0002292)2.27208494
137GDP-mannose metabolic process (GO:0019673)2.26874967
138positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.26740703
139regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.26585414
140pentose metabolic process (GO:0019321)2.25968591
141mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.25450060
142T cell migration (GO:0072678)2.24457775
143regulation of necroptotic process (GO:0060544)2.24441294
144regulation of T cell mediated cytotoxicity (GO:0001914)2.24265497
145positive regulation of fatty acid biosynthetic process (GO:0045723)2.24080372
146detection of external biotic stimulus (GO:0098581)2.23434149
147neutrophil activation (GO:0042119)2.22779315
148response to interferon-alpha (GO:0035455)2.22641491
149macrophage activation (GO:0042116)2.22150151
150positive regulation of chemokine biosynthetic process (GO:0045080)2.21161838
151proline biosynthetic process (GO:0006561)2.20570749
152amyloid precursor protein catabolic process (GO:0042987)2.19734110
153granulocyte activation (GO:0036230)2.19508164
154cell redox homeostasis (GO:0045454)2.19330018
155T-helper 1 type immune response (GO:0042088)2.18353137
156DNA strand elongation involved in DNA replication (GO:0006271)2.18168619
157positive regulation of humoral immune response (GO:0002922)2.18072613
158nuclear-transcribed mRNA catabolic process (GO:0000956)2.18069273
159aminoglycoside antibiotic metabolic process (GO:0030647)2.17894249
160positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.17704033
161erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.17546384
162L-phenylalanine catabolic process (GO:0006559)2.17546384
163kinetochore organization (GO:0051383)2.16691891
164tryptophan metabolic process (GO:0006568)2.16639396
165DNA strand elongation (GO:0022616)2.16279880
166cellular component biogenesis (GO:0044085)2.16175524
167regulation of gamma-delta T cell activation (GO:0046643)2.16088596
168positive regulation of natural killer cell activation (GO:0032816)2.15931168
169toxin transport (GO:1901998)2.15494672
170positive regulation of antigen processing and presentation (GO:0002579)2.14996519
171negative regulation of nitric oxide biosynthetic process (GO:0045019)2.14550014
172peptidyl-glutamic acid carboxylation (GO:0017187)2.13964157
173protein carboxylation (GO:0018214)2.13964157
174regulation of natural killer cell differentiation (GO:0032823)2.13852038
175lymph node development (GO:0048535)2.13469362
176chaperone-mediated protein transport (GO:0072321)2.13360195
177oxidative phosphorylation (GO:0006119)2.13203552
178angiotensin maturation (GO:0002003)2.12787888
179regulation of vitamin D biosynthetic process (GO:0060556)2.12767975
180energy coupled proton transport, down electrochemical gradient (GO:0015985)2.12653256
181ATP synthesis coupled proton transport (GO:0015986)2.12653256
182regulation of RIG-I signaling pathway (GO:0039535)2.12497379
183mature B cell differentiation (GO:0002335)2.12497297
184deoxyribose phosphate metabolic process (GO:0019692)2.11726192
185positive regulation of acute inflammatory response (GO:0002675)2.11614229
186nucleoside salvage (GO:0043174)2.10703109
187regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.10499285
188detection of biotic stimulus (GO:0009595)2.10404417
189pinocytosis (GO:0006907)2.10361742
190I-kappaB phosphorylation (GO:0007252)2.09932649
191myeloid dendritic cell activation (GO:0001773)2.09677799
192cytokine secretion (GO:0050663)2.07847606
193positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.07300751
194positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.06822936
195myeloid cell activation involved in immune response (GO:0002275)2.06557710
196hydrogen peroxide biosynthetic process (GO:0050665)2.05150334
197monocyte chemotaxis (GO:0002548)2.05079500
198CD4-positive, alpha-beta T cell activation (GO:0035710)2.03975143
199response to host immune response (GO:0052572)2.03824241
200response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.03824241

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.69258018
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.20107635
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.85474839
4BP1_19119308_ChIP-ChIP_Hs578T_Human3.43280239
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.18882684
6TP63_17297297_ChIP-ChIP_HaCaT_Human2.98917091
7GATA1_22025678_ChIP-Seq_K562_Human2.98705222
8MYC_18555785_ChIP-Seq_MESCs_Mouse2.94180521
9IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.91726039
10ELF1_17652178_ChIP-ChIP_JURKAT_Human2.87574273
11EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.84471498
12STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.79006939
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.58361257
14SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.56877225
15SMAD_19615063_ChIP-ChIP_OVARY_Human2.42167229
16* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.40230197
17PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.40100021
18SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.36685106
19IRF8_21731497_ChIP-ChIP_J774_Mouse2.35694480
20Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.31847406
21* STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.30235296
22KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.27779219
23GABP_17652178_ChIP-ChIP_JURKAT_Human2.23297136
24HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.22341413
25IRF8_27001747_Chip-Seq_BMDM_Mouse2.19165294
26ZNF263_19887448_ChIP-Seq_K562_Human2.11807743
27* CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.08659962
28CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.05847578
29ETS1_20019798_ChIP-Seq_JURKAT_Human2.00119867
30SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.96352742
31IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.95402966
32RUNX_20019798_ChIP-Seq_JUKART_Human1.93498798
33NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.93177994
34* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.91914429
35VDR_21846776_ChIP-Seq_THP-1_Human1.90478987
36SCL_19346495_ChIP-Seq_HPC-7_Human1.90071561
37CREB1_15753290_ChIP-ChIP_HEK293T_Human1.87441888
38E2F1_18555785_ChIP-Seq_MESCs_Mouse1.85175623
39MYC_19030024_ChIP-ChIP_MESCs_Mouse1.84448697
40DCP1A_22483619_ChIP-Seq_HELA_Human1.84015336
41CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.83367513
42NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.83247739
43CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.81268287
44EGR1_23403033_ChIP-Seq_LIVER_Mouse1.80955238
45* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.80428491
46ZFX_18555785_ChIP-Seq_MESCs_Mouse1.77996236
47VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.77033478
48ERG_20887958_ChIP-Seq_HPC-7_Mouse1.76203073
49* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.75778266
50* GABP_19822575_ChIP-Seq_HepG2_Human1.75687964
51* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.72449039
52FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.69778032
53GBX2_23144817_ChIP-Seq_PC3_Human1.69439314
54STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.67734493
55TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.66725467
56CDX2_19796622_ChIP-Seq_MESCs_Mouse1.66593993
57MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.61978054
58PCGF2_27294783_Chip-Seq_ESCs_Mouse1.61317367
59SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.61175077
60CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.60374028
61FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.59377953
62RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.58565228
63FOXP3_21729870_ChIP-Seq_TREG_Human1.58549532
64XRN2_22483619_ChIP-Seq_HELA_Human1.56661675
65SUZ12_27294783_Chip-Seq_NPCs_Mouse1.56283852
66SRF_21415370_ChIP-Seq_HL-1_Mouse1.55761431
67PCGF2_27294783_Chip-Seq_NPCs_Mouse1.54533287
68FLI1_27457419_Chip-Seq_LIVER_Mouse1.53206301
69FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.51703925
70* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.51332225
71TFEB_21752829_ChIP-Seq_HELA_Human1.50605757
72MYC_19079543_ChIP-ChIP_MESCs_Mouse1.50200284
73FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.50013925
74GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.48869935
75TRIM28_21343339_ChIP-Seq_HEK293_Human1.48644897
76ZFP57_27257070_Chip-Seq_ESCs_Mouse1.47572873
77GATA2_21666600_ChIP-Seq_HMVEC_Human1.47374161
78* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.47059864
79VDR_24787735_ChIP-Seq_THP-1_Human1.46954762
80TTF2_22483619_ChIP-Seq_HELA_Human1.45736155
81NFE2_27457419_Chip-Seq_LIVER_Mouse1.44799150
82DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.44478587
83EZH2_27294783_Chip-Seq_NPCs_Mouse1.43932964
84PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.42873403
85* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.42184983
86VDR_23849224_ChIP-Seq_CD4+_Human1.41488445
87ELK1_19687146_ChIP-ChIP_HELA_Human1.40641596
88PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.40171407
89EST1_17652178_ChIP-ChIP_JURKAT_Human1.39638448
90TP53_18474530_ChIP-ChIP_U2OS_Human1.39090940
91PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.38629005
92E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.38116483
93ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.36621449
94HIF1A_21447827_ChIP-Seq_MCF-7_Human1.36615639
95AR_21909140_ChIP-Seq_LNCAP_Human1.36112736
96PIAS1_25552417_ChIP-Seq_VCAP_Human1.36044870
97NRF2_20460467_ChIP-Seq_MEFs_Mouse1.35464638
98NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.35464638
99TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.34428040
100LXR_22158963_ChIP-Seq_LIVER_Mouse1.32345816
101ESR1_15608294_ChIP-ChIP_MCF-7_Human1.31623474
102FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.30559758
103TP53_16413492_ChIP-PET_HCT116_Human1.30168561
104KDM5A_27292631_Chip-Seq_BREAST_Human1.30028744
105E2F4_17652178_ChIP-ChIP_JURKAT_Human1.29993726
106* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.29978757
107SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.29174155
108CJUN_26792858_Chip-Seq_BT549_Human1.28777950
109SPI1_23547873_ChIP-Seq_NB4_Human1.27429070
110PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.27077783
111* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.25526845
112MYB_21317192_ChIP-Seq_ERMYB_Mouse1.24875699
113HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.24072036
114* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.23985137
115PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.22344067
116NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.22217210
117AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.21892979
118NOTCH1_21737748_ChIP-Seq_TLL_Human1.21569834
119NCOR1_26117541_ChIP-Seq_K562_Human1.20701761
120* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.20633205
121VDR_24763502_ChIP-Seq_THP-1_Human1.19807398
122* P53_22387025_ChIP-Seq_ESCs_Mouse1.19043101
123E2F1_21310950_ChIP-Seq_MCF-7_Human1.18925366
124STAT4_19710469_ChIP-ChIP_TH1__Mouse1.18837722
125CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.18275377
126EGR1_19374776_ChIP-ChIP_THP-1_Human1.18210640
127* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.18133776
128* NANOG_18555785_Chip-Seq_ESCs_Mouse1.16194737
129CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.16075929
130BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.16039054
131* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.13523237
132ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.13510626
133CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.13343863
134ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.12123391
135* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.11799950
136GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.11720357
137* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.11506397
138* STAT3_18555785_Chip-Seq_ESCs_Mouse1.10817181
139THAP11_20581084_ChIP-Seq_MESCs_Mouse1.10590179
140* PU1_27457419_Chip-Seq_LIVER_Mouse1.10220456
141* P300_19829295_ChIP-Seq_ESCs_Human1.10174937
142* E2F1_18555785_Chip-Seq_ESCs_Mouse1.08868179
143ESR1_21235772_ChIP-Seq_MCF-7_Human1.05475179
144TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.04926927
145RXR_22158963_ChIP-Seq_LIVER_Mouse1.04727967
146* CTCF_18555785_ChIP-Seq_MESCs_Mouse1.04707750
147* NMYC_18555785_Chip-Seq_ESCs_Mouse1.04473963
148PU_27001747_Chip-Seq_BMDM_Mouse1.04035105
149* CMYC_18555785_Chip-Seq_ESCs_Mouse1.02376836
150* OCT4_18555785_Chip-Seq_ESCs_Mouse1.01898280
151* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.01360557
152* ELK3_25401928_ChIP-Seq_HUVEC_Human1.01262005
153* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.01170657
154TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00992816
155GATA2_22383799_ChIP-Seq_G1ME_Mouse1.00969973
156BRD4_27068464_Chip-Seq_AML-cells_Mouse1.00577138
157GATA1_22383799_ChIP-Seq_G1ME_Mouse1.00049331
158SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.99369898
159BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.99118932
160OCT4_21477851_ChIP-Seq_ESCs_Mouse0.98894673
161NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.98753107
162CRX_20693478_ChIP-Seq_RETINA_Mouse0.98354119
163RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.97978902
164P300_18555785_Chip-Seq_ESCs_Mouse0.97442581
165HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.96517937
166* SOX2_18555785_Chip-Seq_ESCs_Mouse0.95718998
167RUNX1_27457419_Chip-Seq_LIVER_Mouse0.95713587
168RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.95217416
169WT1_19549856_ChIP-ChIP_CCG9911_Human0.95166026
170SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.95113630
171TBX5_21415370_ChIP-Seq_HL-1_Mouse0.94911868
172RARG_19884340_ChIP-ChIP_MEFs_Mouse0.94666747
173MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.94461202
174TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94398697
175BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.93948947
176LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.93935939
177TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.93838757
178SRY_22984422_ChIP-ChIP_TESTIS_Rat0.93769151
179MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.92973560
180MYB_26560356_Chip-Seq_TH2_Human0.91744714
181ESRRB_18555785_Chip-Seq_ESCs_Mouse0.91494803
182SOX9_24532713_ChIP-Seq_HFSC_Mouse0.91478067
183PPARA_22158963_ChIP-Seq_LIVER_Mouse0.91403797
184* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.90736407
185SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.90589131
186SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.90589131
187SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.90195260
188ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.88703111
189SOX2_20726797_ChIP-Seq_SW620_Human0.88037856
190BCAT_22108803_ChIP-Seq_LS180_Human0.88026074
191* SMAD1_18555785_Chip-Seq_ESCs_Mouse0.87825964
192* SMAD4_21799915_ChIP-Seq_A2780_Human0.87205276

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation3.48733830
2MP0009840_abnormal_foam_cell3.30399909
3MP0009278_abnormal_bone_marrow3.10582511
4MP0001835_abnormal_antigen_presentation2.94291141
5MP0003724_increased_susceptibility_to2.84910288
6MP0003806_abnormal_nucleotide_metabolis2.77958584
7MP0005451_abnormal_body_composition2.58374493
8MP0003436_decreased_susceptibility_to2.47252816
9MP0003186_abnormal_redox_activity2.43942867
10MP0002166_altered_tumor_susceptibility2.41952480
11MP0005397_hematopoietic_system_phenotyp2.36729157
12MP0001545_abnormal_hematopoietic_system2.36729157
13MP0002419_abnormal_innate_immunity2.25808835
14MP0000569_abnormal_digit_pigmentation2.25230184
15MP0005671_abnormal_response_to2.23349440
16MP0002138_abnormal_hepatobiliary_system2.22137462
17MP0002006_tumorigenesis2.16659462
18MP0009785_altered_susceptibility_to2.13626904
19MP0008438_abnormal_cutaneous_collagen2.12281601
20MP0002148_abnormal_hypersensitivity_rea2.11868340
21MP0005000_abnormal_immune_tolerance1.97419012
22MP0001790_abnormal_immune_system1.95945338
23MP0005387_immune_system_phenotype1.95945338
24MP0009384_cardiac_valve_regurgitation1.89117811
25MP0006082_CNS_inflammation1.87814181
26MP0003252_abnormal_bile_duct1.84370790
27MP0005025_abnormal_response_to1.78558254
28MP0003045_fibrosis1.77273660
29MP0002452_abnormal_antigen_presenting1.75797223
30MP0005503_abnormal_tendon_morphology1.75760246
31MP0005464_abnormal_platelet_physiology1.75519601
32MP0002998_abnormal_bone_remodeling1.75497336
33MP0010234_abnormal_vibrissa_follicle1.71349646
34MP0005058_abnormal_lysosome_morphology1.71054625
35MP0005365_abnormal_bile_salt1.69505463
36MP0010030_abnormal_orbit_morphology1.68394606
37MP0002009_preneoplasia1.67490275
38MP0001800_abnormal_humoral_immune1.65696190
39MP0005220_abnormal_exocrine_pancreas1.63538816
40MP0005174_abnormal_tail_pigmentation1.63215226
41MP0002723_abnormal_immune_serum1.63005994
42MP0004381_abnormal_hair_follicle1.60609323
43MP0009764_decreased_sensitivity_to1.60145503
44MP0003300_gastrointestinal_ulcer1.59229917
45MP0003656_abnormal_erythrocyte_physiolo1.57952030
46MP0008260_abnormal_autophagy1.57586562
47MP0003183_abnormal_peptide_metabolism1.54009870
48MP0000685_abnormal_immune_system1.50675007
49MP0001533_abnormal_skeleton_physiology1.49169436
50MP0000015_abnormal_ear_pigmentation1.47773472
51MP0001819_abnormal_immune_cell1.47728367
52MP0002420_abnormal_adaptive_immunity1.47720030
53MP0002877_abnormal_melanocyte_morpholog1.46818753
54MP0001881_abnormal_mammary_gland1.44497574
55MP0002653_abnormal_ependyma_morphology1.44446245
56MP0003279_aneurysm1.42062024
57MP0005360_urolithiasis1.41276146
58MP0005408_hypopigmentation1.39997648
59MP0002933_joint_inflammation1.39931599
60MP0005501_abnormal_skin_physiology1.38453690
61MP0000465_gastrointestinal_hemorrhage1.37862253
62MP0001873_stomach_inflammation1.37551983
63MP0003763_abnormal_thymus_physiology1.36249449
64MP0003172_abnormal_lysosome_physiology1.34956211
65MP0003868_abnormal_feces_composition1.32798003
66MP0002928_abnormal_bile_duct1.32331051
67MP0009697_abnormal_copulation1.28165206
68MP0008057_abnormal_DNA_replication1.26347542
69MP0004272_abnormal_basement_membrane1.26178601
70MP0001188_hyperpigmentation1.25907280
71MP0001845_abnormal_inflammatory_respons1.24150103
72MP0008004_abnormal_stomach_pH1.24007088
73MP0008007_abnormal_cellular_replicative1.23707479
74MP0008469_abnormal_protein_level1.21158818
75MP0010094_abnormal_chromosome_stability1.20769008
76MP0005075_abnormal_melanosome_morpholog1.19581334
77MP0005319_abnormal_enzyme/_coenzyme1.19531624
78MP0001727_abnormal_embryo_implantation1.19422996
79MP0003195_calcinosis1.19376430
80MP0004947_skin_inflammation1.18973386
81MP0003786_premature_aging1.18943698
82MP0002254_reproductive_system_inflammat1.18411516
83MP0000371_diluted_coat_color1.17805290
84MP0004808_abnormal_hematopoietic_stem1.17348703
85MP0010155_abnormal_intestine_physiology1.14708367
86MP0000767_abnormal_smooth_muscle1.12558136
87MP0001764_abnormal_homeostasis1.12198898
88MP0001879_abnormal_lymphatic_vessel1.12026253
89MP0005085_abnormal_gallbladder_physiolo1.11881261
90MP0005171_absent_coat_pigmentation1.11493540
91MP0002396_abnormal_hematopoietic_system1.10941428
92MP0004957_abnormal_blastocyst_morpholog1.10553412
93MP0002405_respiratory_system_inflammati1.10543759
94MP0001666_abnormal_nutrient_absorption1.10374799
95MP0002277_abnormal_respiratory_mucosa1.09323982
96MP0003828_pulmonary_edema1.09154144
97MP0004264_abnormal_extraembryonic_tissu1.08762466
98MP0004510_myositis1.07874954
99MP0005390_skeleton_phenotype1.06655362
100MP0008932_abnormal_embryonic_tissue1.06630465
101MP0006054_spinal_hemorrhage1.04943345
102MP0002796_impaired_skin_barrier1.04670769
103MP0002693_abnormal_pancreas_physiology1.03627805
104MP0002139_abnormal_hepatobiliary_system1.02907643
105MP0001216_abnormal_epidermal_layer1.02678155
106MP0002168_other_aberrant_phenotype1.02465533
107MP0000383_abnormal_hair_follicle1.01572541
108MP0000716_abnormal_immune_system1.01173088
109MP0008058_abnormal_DNA_repair1.00711715
110MP0005257_abnormal_intraocular_pressure1.00615248
111MP0009333_abnormal_splenocyte_physiolog1.00357530
112MP0002060_abnormal_skin_morphology0.99906814
113MP0006036_abnormal_mitochondrial_physio0.99846271
114MP0003453_abnormal_keratinocyte_physiol0.98718565
115MP0000627_abnormal_mammary_gland0.98526407
116MP0004782_abnormal_surfactant_physiolog0.96824003
117MP0003795_abnormal_bone_structure0.96244901
118MP0000609_abnormal_liver_physiology0.96128292
119MP0000678_abnormal_parathyroid_gland0.94641783
120MP0003718_maternal_effect0.94597422
121MP0010368_abnormal_lymphatic_system0.94480128
122MP0005084_abnormal_gallbladder_morpholo0.94410067
123MP0005083_abnormal_biliary_tract0.91064411
124MP0001346_abnormal_lacrimal_gland0.90055346
125MP0003690_abnormal_glial_cell0.89819490
126MP0000598_abnormal_liver_morphology0.88872325
127MP0003191_abnormal_cellular_cholesterol0.88310754
128MP0008789_abnormal_olfactory_epithelium0.87429140
129MP0003303_peritoneal_inflammation0.87298742
130MP0003111_abnormal_nucleus_morphology0.86723069
131MP0009643_abnormal_urine_homeostasis0.86177921
132MP0002398_abnormal_bone_marrow0.85734850
133MP0009763_increased_sensitivity_to0.85203289
134MP0000681_abnormal_thyroid_gland0.85002029
135MP0003136_yellow_coat_color0.84841124
136MP0005310_abnormal_salivary_gland0.83094144
137MP0005409_darkened_coat_color0.82913104
138MP0000858_altered_metastatic_potential0.82894412
139MP0005023_abnormal_wound_healing0.82796413
140MP0003941_abnormal_skin_development0.82144646
141MP0010386_abnormal_urinary_bladder0.81877370
142MP0003448_altered_tumor_morphology0.81337689
143MP0003693_abnormal_embryo_hatching0.80778592
144MP0001243_abnormal_dermal_layer0.80670962
145MP0003566_abnormal_cell_adhesion0.79228080
146MP0005275_abnormal_skin_tensile0.78721546
147MP0000358_abnormal_cell_content/0.78077412
148MP0000490_abnormal_crypts_of0.77305166
149MP0001958_emphysema0.77144387
150MP0001853_heart_inflammation0.77044559
151MP0005670_abnormal_white_adipose0.76522107
152MP0000249_abnormal_blood_vessel0.75506631
153MP0002098_abnormal_vibrissa_morphology0.75111802
154MP0000343_altered_response_to0.73988188
155MP0002019_abnormal_tumor_incidence0.73932538
156MP0002295_abnormal_pulmonary_circulatio0.70780512
157MP0008875_abnormal_xenobiotic_pharmacok0.70203861
158MP0009765_abnormal_xenobiotic_induced0.69058548
159MP0001661_extended_life_span0.67643540
160MP0002970_abnormal_white_adipose0.67304455
161MP0010678_abnormal_skin_adnexa0.66961519
162MP0001542_abnormal_bone_strength0.65592110
163MP0005508_abnormal_skeleton_morphology0.65185467
164MP0002429_abnormal_blood_cell0.65009710
165MP0010771_integument_phenotype0.64321753
166MP0005410_abnormal_fertilization0.63564785
167MP0005332_abnormal_amino_acid0.61574303
168MP0000377_abnormal_hair_follicle0.61571080

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)3.75327047
2Aplasia/Hypoplasia of the sacrum (HP:0008517)3.54294359
3Recurrent gram-negative bacterial infections (HP:0005420)3.49046651
4Beaking of vertebral bodies (HP:0004568)3.37647219
5Reticulocytopenia (HP:0001896)3.35921655
6Joint hemorrhage (HP:0005261)3.28028212
7Vertebral compression fractures (HP:0002953)3.18569568
8Recurrent abscess formation (HP:0002722)3.10519839
9Recurrent bacterial skin infections (HP:0005406)3.03712279
10Prolonged partial thromboplastin time (HP:0003645)2.93925922
11Metaphyseal dysplasia (HP:0100255)2.84404569
12Gingival bleeding (HP:0000225)2.84162516
13Vacuolated lymphocytes (HP:0001922)2.79746365
14Spondylolisthesis (HP:0003302)2.74797087
15Abnormal mitochondria in muscle tissue (HP:0008316)2.73464621
16Acute encephalopathy (HP:0006846)2.70818901
17Cerebral edema (HP:0002181)2.67531274
18Recurrent fungal infections (HP:0002841)2.67338240
19Abnormality of aromatic amino acid family metabolism (HP:0004338)2.65825728
20Optic neuritis (HP:0100653)2.64747403
21Retrobulbar optic neuritis (HP:0100654)2.64747403
22Orchitis (HP:0100796)2.64269859
23Myositis (HP:0100614)2.64024458
24Microretrognathia (HP:0000308)2.63173549
25Acute necrotizing encephalopathy (HP:0006965)2.60646996
26Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.58797826
27Decreased activity of mitochondrial respiratory chain (HP:0008972)2.58797826
28Periodontitis (HP:0000704)2.58535116
29Abnormality of cells of the erythroid lineage (HP:0012130)2.57880833
30Hyperthyroidism (HP:0000836)2.54670573
31Prostate neoplasm (HP:0100787)2.53960910
32Epistaxis (HP:0000421)2.51974022
33Macrocytic anemia (HP:0001972)2.50591351
34Cervical subluxation (HP:0003308)2.47695390
35Chronic diarrhea (HP:0002028)2.44007516
36Onycholysis (HP:0001806)2.43163193
37Lip pit (HP:0100267)2.43036019
38Broad face (HP:0000283)2.41930091
39Dysostosis multiplex (HP:0000943)2.40815546
40Abnormality of polysaccharide metabolism (HP:0011012)2.36540442
41Abnormality of glycosaminoglycan metabolism (HP:0004371)2.36540442
42Abnormality of mucopolysaccharide metabolism (HP:0011020)2.36540442
43Myocardial infarction (HP:0001658)2.34839470
44Renal cortical cysts (HP:0000803)2.33636087
45Abnormality of the intrinsic pathway (HP:0010989)2.32694669
46Thrombocytosis (HP:0001894)2.32653559
47Hepatocellular necrosis (HP:0001404)2.30194989
48Recurrent viral infections (HP:0004429)2.29868811
49Hyperammonemia (HP:0001987)2.29776034
50Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.29512664
51Mitochondrial inheritance (HP:0001427)2.28960774
52Mediastinal lymphadenopathy (HP:0100721)2.28014962
53Prolonged bleeding time (HP:0003010)2.27360357
54Gingivitis (HP:0000230)2.27198035
55Petechiae (HP:0000967)2.26797756
56J-shaped sella turcica (HP:0002680)2.26794343
57Intrahepatic cholestasis (HP:0001406)2.23015804
58Hepatic necrosis (HP:0002605)2.22892414
59Menorrhagia (HP:0000132)2.21494569
60Increased muscle lipid content (HP:0009058)2.20853447
61Chronic hepatic failure (HP:0100626)2.19828953
62Urinary glycosaminoglycan excretion (HP:0003541)2.19638033
63Mucopolysacchariduria (HP:0008155)2.19638033
64Recurrent skin infections (HP:0001581)2.18684751
65Abnormality of the common coagulation pathway (HP:0010990)2.18638642
66Spontaneous hematomas (HP:0007420)2.16428057
67Abnormal pupillary function (HP:0007686)2.15983471
68Abnormal platelet function (HP:0011869)2.15479336
69Impaired platelet aggregation (HP:0003540)2.15479336
70Alveolar cell carcinoma (HP:0006519)2.14699698
71Abnormality of the renal cortex (HP:0011035)2.14088249
7211 pairs of ribs (HP:0000878)2.13725291
73Autoimmune thrombocytopenia (HP:0001973)2.13350184
74Hypertensive crisis (HP:0100735)2.12646830
75Symptomatic seizures (HP:0011145)2.12166741
76Increased intramyocellular lipid droplets (HP:0012240)2.11669073
77Arterial thrombosis (HP:0004420)2.10355457
78Pulmonary infiltrates (HP:0002113)2.09401627
79Systemic lupus erythematosus (HP:0002725)2.08667912
80Fragile nails (HP:0001808)2.08511533
81Tubulointerstitial nephritis (HP:0001970)2.07757681
82Loss of speech (HP:0002371)2.06628063
83Vasculitis (HP:0002633)2.06574850
84Hypokinesia (HP:0002375)2.05230446
85Abnormality of the acetabulum (HP:0003170)2.05209447
86Thoracic kyphosis (HP:0002942)2.04683219
87Chronic mucocutaneous candidiasis (HP:0002728)2.04235589
88Recurrent cutaneous fungal infections (HP:0011370)2.04235589
89Abnormality of the fingertips (HP:0001211)2.04181511
90Progressive neurologic deterioration (HP:0002344)2.03056372
91Thick nail (HP:0001805)2.02627257
92Renal Fanconi syndrome (HP:0001994)2.02604620
93Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.02577534
94Prolonged neonatal jaundice (HP:0006579)2.02081044
95Abnormality of the frontal sinuses (HP:0002687)2.01109527
96Abnormality of T cell number (HP:0011839)1.99302496
97Abnormal delayed hypersensitivity skin test (HP:0002963)1.98937342
98Hematochezia (HP:0002573)1.98458134
99Bruising susceptibility (HP:0000978)1.98293285
100Microglossia (HP:0000171)1.98222263
101Hypoglycemic seizures (HP:0002173)1.97937728
102Absent frontal sinuses (HP:0002688)1.96894389
103Orthostatic hypotension (HP:0001278)1.95907660
104Atrophic scars (HP:0001075)1.95691115
105Pallor (HP:0000980)1.95293494
106Increased CSF lactate (HP:0002490)1.95197338
107Conjugated hyperbilirubinemia (HP:0002908)1.94889761
108Abnormality of glycolysis (HP:0004366)1.92487582
109Neoplasm of the tracheobronchial system (HP:0100552)1.91849727
110Seborrheic dermatitis (HP:0001051)1.91633931
111Acute myeloid leukemia (HP:0004808)1.90641485
112Osteolytic defects of the phalanges of the hand (HP:0009771)1.90050501
113Osteolytic defects of the hand bones (HP:0009699)1.90050501
114Complement deficiency (HP:0004431)1.89774380
115Craniofacial hyperostosis (HP:0004493)1.87682484
116Stomatitis (HP:0010280)1.87575283
117Cranial hyperostosis (HP:0004437)1.86304115
118Glomerulonephritis (HP:0000099)1.85513446
119T lymphocytopenia (HP:0005403)1.84821080
120Elevated erythrocyte sedimentation rate (HP:0003565)1.84621928
121Aortic regurgitation (HP:0001659)1.83832286
122Cardiomegaly (HP:0001640)1.83585637
123Portal hypertension (HP:0001409)1.83566440
124Villous atrophy (HP:0011473)1.83215727
125Abnormality of small intestinal villus morphology (HP:0011472)1.83215727
126Type I transferrin isoform profile (HP:0003642)1.81931367
127Premature rupture of membranes (HP:0001788)1.81907315
128Keratoconjunctivitis sicca (HP:0001097)1.81858482
129Abnormal hemoglobin (HP:0011902)1.81143154
130Abnormal gallbladder physiology (HP:0012438)1.80858829
131Cholecystitis (HP:0001082)1.80858829
132Abnormality of the nasal septum (HP:0000419)1.80481329
133Progressive macrocephaly (HP:0004481)1.78734422
134Nephritis (HP:0000123)1.78516279
135Lipid accumulation in hepatocytes (HP:0006561)1.77252341
136Abnormality of macrophages (HP:0004311)1.76949356
137Hypoparathyroidism (HP:0000829)1.75672082
138Obstructive lung disease (HP:0006536)1.75200428
139Chronic obstructive pulmonary disease (HP:0006510)1.75200428
140Biconcave vertebral bodies (HP:0004586)1.74718375
141Abnormality of the hepatic vasculature (HP:0006707)1.74030472
142Meningitis (HP:0001287)1.73329282
143Deformed sella turcica (HP:0002681)1.72581390
144Esophageal neoplasm (HP:0100751)1.71791024
145Neoplasm of head and neck (HP:0012288)1.71791024
146Chronic otitis media (HP:0000389)1.71453250
147Abnormality of homocysteine metabolism (HP:0010919)1.71431361
148Homocystinuria (HP:0002156)1.71431361
149Vertebral hypoplasia (HP:0008417)1.71207941
150Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.71207941
151Purpura (HP:0000979)1.71073072
152Osteomyelitis (HP:0002754)1.70560367
153Abnormality of the prostate (HP:0008775)1.68505258
154Abnormality of complement system (HP:0005339)1.68084760
155Decreased circulating renin level (HP:0003351)1.67796282
156Abnormality of the thoracic spine (HP:0100711)1.67794909
157Axonal loss (HP:0003447)1.67516219
158Lactic acidosis (HP:0003128)1.67383249
159Cupped ribs (HP:0000887)1.67166438
160Hemoptysis (HP:0002105)1.66454661
161Abnormality of the tricuspid valve (HP:0001702)1.66000531
162Abnormality of monocarboxylic acid metabolism (HP:0010996)1.65758446
163Abnormality of glycolipid metabolism (HP:0010969)1.65688629
164Abnormality of liposaccharide metabolism (HP:0010968)1.65688629
165Abnormality of glycosphingolipid metabolism (HP:0004343)1.65688629
166Autoimmune hemolytic anemia (HP:0001890)1.65482814
167Aortic aneurysm (HP:0004942)1.64880758
168Spastic paraparesis (HP:0002313)1.60643990
169Plantar hyperkeratosis (HP:0007556)1.60003660
170Congenital ichthyosiform erythroderma (HP:0007431)1.59904577
171Lethargy (HP:0001254)1.59804796
172Increased cerebral lipofuscin (HP:0011813)1.59674899
173Respiratory failure (HP:0002878)1.59181918
1743-Methylglutaconic aciduria (HP:0003535)1.58987473
175Increased serum pyruvate (HP:0003542)1.58951818
176Increased neuronal autofluorescent lipopigment (HP:0002074)1.58654563
177Irregular vertebral endplates (HP:0003301)1.58536700
178Abnormality of the vasculature of the conjunctiva (HP:0008054)1.57376229
179Amyloidosis (HP:0011034)1.57035038
180Absent thumb (HP:0009777)1.56718001
181Nuclear cataract (HP:0100018)1.56011022
182Aplasia/Hypoplasia involving the vertebral column (HP:0008518)1.55820347

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK3.53041119
2SCYL23.27789784
3NME23.22860413
4IRAK33.20153068
5INSRR3.18995359
6MAP3K142.91023376
7ARAF2.90373675
8TXK2.68736883
9IRAK42.66387490
10CDC72.52065749
11MAP3K112.38622685
12TAOK32.37528043
13TGFBR22.27688409
14TESK12.20317396
15JAK12.16243308
16NUAK12.12301254
17JAK32.10448186
18TESK22.10284391
19IKBKE2.02870296
20TYK21.99543124
21ABL21.87340833
22FRK1.76787430
23EPHA31.73212530
24LATS11.70632349
25EIF2AK21.62094016
26STK161.59197568
27TEC1.58675884
28ZAK1.58016311
29NLK1.53932060
30KIT1.53856409
31ERN11.53590939
32IKBKB1.52003520
33SIK11.50824851
34EIF2AK11.49376637
35EPHA21.48501661
36FGFR31.48222352
37TNIK1.47949573
38PIK3CG1.47871015
39KDR1.46524430
40FGFR41.45533998
41MAP3K121.45320178
42CAMK1D1.44490946
43TRPM71.39732957
44ILK1.39114350
45CHUK1.37812098
46BRAF1.34731809
47MAP4K11.33545818
48MOS1.31687091
49EIF2AK31.29519339
50LRRK21.27437683
51GRK61.27381735
52RPS6KB21.25997039
53GRK71.21707000
54TBK11.21275647
55MYLK1.18072521
56TRIM281.17604362
57IRAK11.16695482
58BLK1.15506111
59CAMK1G1.10504210
60MATK1.10314196
61RIPK41.10242364
62FLT31.09894977
63ZAP701.07975005
64PLK41.06963923
65PIK3CA1.06543956
66NEK91.01998891
67CSK1.00110933
68NEK60.99421546
69EPHB20.99218559
70MAPK150.98190489
71TIE10.98112454
72NEK10.97095668
73HCK0.93274002
74TAOK20.93235883
75MST1R0.92830451
76PAK40.92567435
77AURKB0.92555504
78STK240.92543582
79BMPR20.91336768
80TTK0.90453065
81PDK20.88031337
82BTK0.87924619
83YES10.87600744
84LCK0.87073048
85VRK20.86427565
86DMPK0.85519477
87BRD40.84482084
88RAF10.84401659
89AURKA0.84131541
90MAP3K20.79912741
91PDGFRB0.79363411
92MAP3K10.79227533
93ITK0.77042033
94LYN0.76574962
95GRK10.75956998
96EPHB10.75931514
97PIM20.75866598
98CSF1R0.75638202
99PRKD20.75380874
100PRKAA20.75171902
101MAP2K30.75134948
102CDK70.75113543
103MAP2K20.74276330
104JAK20.71839052
105STK30.68869864
106MKNK20.68335074
107MAPK70.67089106
108PIM10.63447015
109DYRK1B0.63197093
110TNK20.62671538
111SYK0.62423289
112ATR0.61107596
113CHEK20.60903207
114SGK20.60449006
115HIPK20.60438927
116DAPK30.59828209
117IGF1R0.59574119
118MAP3K30.59278907
119CDK80.58442781
120PBK0.56893159
121ABL10.55639409
122CSNK2A10.55359557
123PLK10.55201502
124PRKCQ0.55079406
125PRKCI0.54858339
126MUSK0.54708047
127PTK60.54375509
128SMG10.53822261
129AKT20.52641598
130CHEK10.52582617
131MAP4K20.51746487
132MST40.51597886
133CSNK2A20.51230688
134CDK30.49942887
135SGK30.49713461
136FES0.49470973
137STK390.49452720
138STK100.49221453
139IRAK20.48936086
140AKT30.48721601
141MAP3K80.48485060
142BMX0.47253288
143CDK120.45934002
144PTK20.44907568
145ADRBK20.44103524
146STK40.41231838
147MAP3K70.41181252
148MAPKAPK30.41041710
149INSR0.40652048
150PRKCE0.40005227
151PKN10.39885296
152CDK90.39251041
153FGFR20.39054169
154CLK10.37449900
155MTOR0.37154902
156CDK60.33919198
157PAK10.33899694
158SRPK10.32890180
159LIMK10.32431708
160CASK0.31958633
161PDGFRA0.30359258
162CDK40.29948448
163MARK20.29910592
164RPS6KL10.29856731
165RPS6KC10.29856731
166GSK3A0.28781652
167MAP3K130.28719553
168RPS6KA40.28409904
169DYRK30.26916979

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030103.67947713
2DNA replication_Homo sapiens_hsa030302.71938122
3Mismatch repair_Homo sapiens_hsa034302.53386797
4Sulfur relay system_Homo sapiens_hsa041222.48126038
5NF-kappa B signaling pathway_Homo sapiens_hsa040642.47978966
6Staphylococcus aureus infection_Homo sapiens_hsa051502.34570530
7Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.34433878
8Graft-versus-host disease_Homo sapiens_hsa053322.23484008
9Leishmaniasis_Homo sapiens_hsa051402.18256834
10Homologous recombination_Homo sapiens_hsa034402.11432733
11Base excision repair_Homo sapiens_hsa034102.02181636
12Allograft rejection_Homo sapiens_hsa053302.01598755
13Maturity onset diabetes of the young_Homo sapiens_hsa049501.96701443
14Glycosaminoglycan degradation_Homo sapiens_hsa005311.94687770
15Toll-like receptor signaling pathway_Homo sapiens_hsa046201.92426483
16Drug metabolism - other enzymes_Homo sapiens_hsa009831.86450501
17Malaria_Homo sapiens_hsa051441.82517282
18Oxidative phosphorylation_Homo sapiens_hsa001901.81830546
19NOD-like receptor signaling pathway_Homo sapiens_hsa046211.79652553
20Proteasome_Homo sapiens_hsa030501.76605192
21Measles_Homo sapiens_hsa051621.76405293
22RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.74561434
23Nucleotide excision repair_Homo sapiens_hsa034201.73276320
24Intestinal immune network for IgA production_Homo sapiens_hsa046721.70775611
25Osteoclast differentiation_Homo sapiens_hsa043801.69664383
26Caffeine metabolism_Homo sapiens_hsa002321.68918755
27Hematopoietic cell lineage_Homo sapiens_hsa046401.66845551
28Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.65661149
29Other glycan degradation_Homo sapiens_hsa005111.64219908
30Fatty acid elongation_Homo sapiens_hsa000621.56774805
31TNF signaling pathway_Homo sapiens_hsa046681.54314556
32Fanconi anemia pathway_Homo sapiens_hsa034601.52785528
33Folate biosynthesis_Homo sapiens_hsa007901.52771774
34Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.51918446
35Jak-STAT signaling pathway_Homo sapiens_hsa046301.50690434
36Glutathione metabolism_Homo sapiens_hsa004801.50616058
37Complement and coagulation cascades_Homo sapiens_hsa046101.49375511
38Pyrimidine metabolism_Homo sapiens_hsa002401.47292237
39Parkinsons disease_Homo sapiens_hsa050121.43595060
40Autoimmune thyroid disease_Homo sapiens_hsa053201.43393528
41Primary immunodeficiency_Homo sapiens_hsa053401.42250552
42Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.40841715
43* Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.37253027
44Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.37169369
45Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.36113589
46Pentose phosphate pathway_Homo sapiens_hsa000301.32621493
47Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.29435513
48SNARE interactions in vesicular transport_Homo sapiens_hsa041301.28711157
49Galactose metabolism_Homo sapiens_hsa000521.27783008
50N-Glycan biosynthesis_Homo sapiens_hsa005101.26739979
51Toxoplasmosis_Homo sapiens_hsa051451.22600646
52Pertussis_Homo sapiens_hsa051331.22088408
53Pentose and glucuronate interconversions_Homo sapiens_hsa000401.21874884
54Lysine degradation_Homo sapiens_hsa003101.21012606
55Rheumatoid arthritis_Homo sapiens_hsa053231.18917474
56ABC transporters_Homo sapiens_hsa020101.17871091
57Asthma_Homo sapiens_hsa053101.17489759
58Huntingtons disease_Homo sapiens_hsa050161.17365918
59Influenza A_Homo sapiens_hsa051641.14843206
60Herpes simplex infection_Homo sapiens_hsa051681.14033300
61Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.14015918
62Primary bile acid biosynthesis_Homo sapiens_hsa001201.12665343
63Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.11263336
64Protein export_Homo sapiens_hsa030601.08409608
65Steroid hormone biosynthesis_Homo sapiens_hsa001401.07396492
66Tuberculosis_Homo sapiens_hsa051521.07363873
67ECM-receptor interaction_Homo sapiens_hsa045121.07292716
68Lysosome_Homo sapiens_hsa041421.05794719
69Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.03604200
70Legionellosis_Homo sapiens_hsa051341.03266929
71Transcriptional misregulation in cancer_Homo sapiens_hsa052020.97232454
72Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.96644063
73Vitamin digestion and absorption_Homo sapiens_hsa049770.96530997
74Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.95743236
75Tryptophan metabolism_Homo sapiens_hsa003800.95033671
76African trypanosomiasis_Homo sapiens_hsa051430.94418925
77Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.92768868
78Protein digestion and absorption_Homo sapiens_hsa049740.91863482
79AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.90769538
80Type I diabetes mellitus_Homo sapiens_hsa049400.90606519
81Carbon metabolism_Homo sapiens_hsa012000.90431800
82Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.90303103
83Hepatitis C_Homo sapiens_hsa051600.86008810
84Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.84991558
85Alzheimers disease_Homo sapiens_hsa050100.84540156
86Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.83964279
87Bladder cancer_Homo sapiens_hsa052190.82494224
88Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.81782314
89Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.81754637
90RNA polymerase_Homo sapiens_hsa030200.81625323
91Metabolic pathways_Homo sapiens_hsa011000.80997075
92Sphingolipid metabolism_Homo sapiens_hsa006000.80010431
93Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.79878322
94Fructose and mannose metabolism_Homo sapiens_hsa000510.79353938
95T cell receptor signaling pathway_Homo sapiens_hsa046600.78804294
96Spliceosome_Homo sapiens_hsa030400.77079393
97Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.75939071
98One carbon pool by folate_Homo sapiens_hsa006700.75413202
99Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.73947404
100Cysteine and methionine metabolism_Homo sapiens_hsa002700.73902127
101Chemokine signaling pathway_Homo sapiens_hsa040620.72911695
102Histidine metabolism_Homo sapiens_hsa003400.72815731
103B cell receptor signaling pathway_Homo sapiens_hsa046620.72814407
104Hepatitis B_Homo sapiens_hsa051610.72076457
105Tyrosine metabolism_Homo sapiens_hsa003500.72069144
106Biosynthesis of amino acids_Homo sapiens_hsa012300.71856925
107p53 signaling pathway_Homo sapiens_hsa041150.71391251
108Antigen processing and presentation_Homo sapiens_hsa046120.70481409
109Platelet activation_Homo sapiens_hsa046110.70063257
110Salmonella infection_Homo sapiens_hsa051320.69746567
111Vibrio cholerae infection_Homo sapiens_hsa051100.68189160
112Small cell lung cancer_Homo sapiens_hsa052220.67436778
113Apoptosis_Homo sapiens_hsa042100.66384206
114Steroid biosynthesis_Homo sapiens_hsa001000.64924853
115Amoebiasis_Homo sapiens_hsa051460.64058315
116Retinol metabolism_Homo sapiens_hsa008300.61269509
117Prolactin signaling pathway_Homo sapiens_hsa049170.59578590
118Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.59212786
119Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.58242781
120Prostate cancer_Homo sapiens_hsa052150.57535093
121beta-Alanine metabolism_Homo sapiens_hsa004100.57171972
122Acute myeloid leukemia_Homo sapiens_hsa052210.56334265
123Leukocyte transendothelial migration_Homo sapiens_hsa046700.56219360
1242-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.56113364
125Peroxisome_Homo sapiens_hsa041460.56036162
126RNA transport_Homo sapiens_hsa030130.55498423
127Phenylalanine metabolism_Homo sapiens_hsa003600.55425169
128Ovarian steroidogenesis_Homo sapiens_hsa049130.55249333
129Fatty acid metabolism_Homo sapiens_hsa012120.54999574
130Viral myocarditis_Homo sapiens_hsa054160.54810979
131Starch and sucrose metabolism_Homo sapiens_hsa005000.54510883
132Circadian rhythm_Homo sapiens_hsa047100.53495256
133Focal adhesion_Homo sapiens_hsa045100.52978581
134Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.52660995
135Chemical carcinogenesis_Homo sapiens_hsa052040.52464542
136Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.51610231
137Fatty acid degradation_Homo sapiens_hsa000710.49440320
138Insulin resistance_Homo sapiens_hsa049310.48723379
139Pancreatic secretion_Homo sapiens_hsa049720.48700321
140Adherens junction_Homo sapiens_hsa045200.47450599
141Phagosome_Homo sapiens_hsa041450.46181300
142Shigellosis_Homo sapiens_hsa051310.45468984
143Non-homologous end-joining_Homo sapiens_hsa034500.45446653
144Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.45347139
145Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.44383817
146Basal transcription factors_Homo sapiens_hsa030220.44279160
147FoxO signaling pathway_Homo sapiens_hsa040680.44137644
148Sulfur metabolism_Homo sapiens_hsa009200.43756652
149Adipocytokine signaling pathway_Homo sapiens_hsa049200.43535837
150Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.42224754
151Renin-angiotensin system_Homo sapiens_hsa046140.41699573
152Type II diabetes mellitus_Homo sapiens_hsa049300.41364959
153Systemic lupus erythematosus_Homo sapiens_hsa053220.41205953
154Proteoglycans in cancer_Homo sapiens_hsa052050.39734794
155Arachidonic acid metabolism_Homo sapiens_hsa005900.39180252
156Pancreatic cancer_Homo sapiens_hsa052120.38972643
157Propanoate metabolism_Homo sapiens_hsa006400.37993776
158Pyruvate metabolism_Homo sapiens_hsa006200.36609206
159RNA degradation_Homo sapiens_hsa030180.34941957
160Purine metabolism_Homo sapiens_hsa002300.34266538
161Arginine and proline metabolism_Homo sapiens_hsa003300.34161369
162Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.34128840

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