DNAJC10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an endoplasmic reticulum co-chaperone which is part of the endoplasmic reticulum-associated degradation complex involved in recognizing and degrading misfolded proteins. The encoded protein reduces incorrect disulfide bonds in misfolded glycoproteins. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1branching involved in prostate gland morphogenesis (GO:0060442)9.57388348
2Golgi transport vesicle coating (GO:0048200)9.37563291
3COPI coating of Golgi vesicle (GO:0048205)9.37563291
4maintenance of protein localization in endoplasmic reticulum (GO:0035437)7.40004012
5prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060526.97342615
6artery development (GO:0060840)6.44215342
7activation of signaling protein activity involved in unfolded protein response (GO:0006987)6.30610147
8mannose metabolic process (GO:0006013)6.24955117
9regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)6.20637553
10positive regulation of nuclease activity (GO:0032075)6.08857175
11protein retention in ER lumen (GO:0006621)5.96493926
12prostate gland epithelium morphogenesis (GO:0060740)5.93754132
13retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)5.55075612
14regulation of nuclease activity (GO:0032069)5.53970076
15response to testosterone (GO:0033574)5.43083242
16endoplasmic reticulum unfolded protein response (GO:0030968)5.39565378
17cellular response to unfolded protein (GO:0034620)5.22875536
18UDP-N-acetylglucosamine metabolic process (GO:0006047)5.22034048
19L-fucose catabolic process (GO:0042355)5.10766432
20fucose catabolic process (GO:0019317)5.10766432
21L-fucose metabolic process (GO:0042354)5.10766432
22cilium or flagellum-dependent cell motility (GO:0001539)5.10352668
23N-glycan processing (GO:0006491)5.06158810
24COPII vesicle coating (GO:0048208)5.01467641
25ER-nucleus signaling pathway (GO:0006984)4.96443494
26regulation of receptor binding (GO:1900120)4.90357402
27cellular response to topologically incorrect protein (GO:0035967)4.86647450
28galactose catabolic process (GO:0019388)4.72658631
29monoubiquitinated protein deubiquitination (GO:0035520)4.67915835
30epithelial cell differentiation involved in prostate gland development (GO:0060742)4.67114197
31vesicle coating (GO:0006901)4.61319001
32fucose metabolic process (GO:0006004)4.60690714
33mitotic cell cycle arrest (GO:0071850)4.56460705
34* ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)4.51462737
35positive regulation of steroid hormone secretion (GO:2000833)4.46181272
36regulation of pigment cell differentiation (GO:0050932)4.38453598
37* response to endoplasmic reticulum stress (GO:0034976)4.31912678
38apoptotic cell clearance (GO:0043277)4.29564748
39epithelial cell maturation (GO:0002070)4.29409533
40activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)4.25312537
41regulation of hippo signaling (GO:0035330)4.20101880
42protein N-linked glycosylation via asparagine (GO:0018279)4.18247800
43peptidyl-asparagine modification (GO:0018196)4.17077136
44nuclear pore complex assembly (GO:0051292)4.12011432
45valine metabolic process (GO:0006573)4.06753517
46response to unfolded protein (GO:0006986)4.06294747
47regulation of establishment of cell polarity (GO:2000114)4.04437124
48sequestering of metal ion (GO:0051238)4.03359881
49positive regulation of developmental pigmentation (GO:0048087)3.97753583
50positive regulation of natural killer cell differentiation (GO:0032825)3.96062853
51intestinal epithelial cell development (GO:0060576)3.92653153
52lipid translocation (GO:0034204)3.92332087
53phospholipid translocation (GO:0045332)3.92332087
54nuclear pore organization (GO:0006999)3.87338191
55response to topologically incorrect protein (GO:0035966)3.81842390
56snRNA transcription (GO:0009301)3.80060780
57protein N-linked glycosylation (GO:0006487)3.78671158
58positive regulation of growth hormone secretion (GO:0060124)3.78024171
59negative regulation of keratinocyte proliferation (GO:0010839)3.73191886
60epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.72812894
61regulation of establishment or maintenance of cell polarity (GO:0032878)3.69428602
62interkinetic nuclear migration (GO:0022027)3.67878569
63ER overload response (GO:0006983)3.65567631
64cytoplasmic mRNA processing body assembly (GO:0033962)3.61526349
65pharyngeal system development (GO:0060037)3.56560392
66pericardium development (GO:0060039)3.55649463
67angiotensin maturation (GO:0002003)3.52158229
68hormone catabolic process (GO:0042447)3.51112539
69regulation of gene silencing by RNA (GO:0060966)3.48677825
70regulation of posttranscriptional gene silencing (GO:0060147)3.48677825
71regulation of gene silencing by miRNA (GO:0060964)3.48677825
72cilium movement (GO:0003341)3.47659583
73regulation of growth hormone secretion (GO:0060123)3.43275885
74protein K48-linked deubiquitination (GO:0071108)3.42147047
75beta-amyloid metabolic process (GO:0050435)3.38684584
76lung secretory cell differentiation (GO:0061140)3.36503471
77regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.27006462
78protein autoprocessing (GO:0016540)3.26907096
79positive regulation of glycoprotein metabolic process (GO:1903020)3.26548135
80peptide catabolic process (GO:0043171)3.26293826
81insulin-like growth factor receptor signaling pathway (GO:0048009)3.24064151
82mitotic sister chromatid cohesion (GO:0007064)3.23954984
83axonemal dynein complex assembly (GO:0070286)3.21150012
84neural tube formation (GO:0001841)3.17588341
85nucleotide-sugar metabolic process (GO:0009225)3.17458384
86antigen processing and presentation via MHC class Ib (GO:0002475)3.16607291
87peptidyl-lysine dimethylation (GO:0018027)3.16072914
88Golgi organization (GO:0007030)3.15047883
89protein targeting to vacuole (GO:0006623)3.14709265
90protein targeting to lysosome (GO:0006622)3.14709265
91establishment of protein localization to vacuole (GO:0072666)3.14709265
92embryonic foregut morphogenesis (GO:0048617)3.11282650
93positive regulation of catenin import into nucleus (GO:0035413)3.07576768
944-hydroxyproline metabolic process (GO:0019471)3.06230297
95regulation of steroid hormone secretion (GO:2000831)3.04730675
96protein targeting to Golgi (GO:0000042)3.02174368
97nucleotide-sugar biosynthetic process (GO:0009226)3.00706997
98pre-miRNA processing (GO:0031054)2.99364804
99intra-Golgi vesicle-mediated transport (GO:0006891)2.99244665
100glandular epithelial cell differentiation (GO:0002067)2.98753393
101regulation of polysaccharide biosynthetic process (GO:0032885)2.97097251
102dorsal/ventral axis specification (GO:0009950)2.96500053
103hypotonic response (GO:0006971)2.88500813
104establishment of protein localization to Golgi (GO:0072600)2.85772553
105fucosylation (GO:0036065)2.83847963
106hexose catabolic process (GO:0019320)2.82322106
107regulation of protein glycosylation (GO:0060049)2.82155229
108nucleus localization (GO:0051647)2.81668561
109retrograde transport, vesicle recycling within Golgi (GO:0000301)2.81453483
110chondrocyte proliferation (GO:0035988)2.80755251
111retina vasculature morphogenesis in camera-type eye (GO:0061299)2.80491478
112glomerular epithelial cell development (GO:0072310)2.79573029
113cellular response to ethanol (GO:0071361)2.79454227
114zinc ion transport (GO:0006829)2.77577456
115pore complex assembly (GO:0046931)2.77569016
116protein hydroxylation (GO:0018126)2.77470544
117signal peptide processing (GO:0006465)2.77018681
118antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.76303569
119antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.76303569
120sequestering of extracellular ligand from receptor (GO:0035581)2.76138913
121regulation of keratinocyte proliferation (GO:0010837)2.75927124
122epithelial cilium movement (GO:0003351)2.75853696
123regulation of transforming growth factor beta2 production (GO:0032909)2.75843378
124peptidyl-proline hydroxylation (GO:0019511)2.74702349
125phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.72451052
126positive regulation of establishment of protein localization to plasma membrane (GO:0090004)2.71669895
127cytoskeletal anchoring at plasma membrane (GO:0007016)2.71563676
128glucocorticoid receptor signaling pathway (GO:0042921)2.70109561
129ER to Golgi vesicle-mediated transport (GO:0006888)2.69151110
130negative regulation of glycogen biosynthetic process (GO:0045719)2.68983516
131regulation of centriole replication (GO:0046599)2.68414763
132corticosteroid receptor signaling pathway (GO:0031958)2.67595207
133multicellular organismal macromolecule metabolic process (GO:0044259)2.67136286
134multicellular organismal catabolic process (GO:0044243)2.66669658
135macroautophagy (GO:0016236)2.66567305
136cellular response to ATP (GO:0071318)2.65453693
137regulation of centrosome duplication (GO:0010824)2.65387287
138positive regulation of peptidyl-threonine phosphorylation (GO:0010800)2.65334129
139positive regulation of glycoprotein biosynthetic process (GO:0010560)2.65196022
140collagen catabolic process (GO:0030574)2.64104400
141potassium ion homeostasis (GO:0055075)2.64008075
142collagen metabolic process (GO:0032963)2.62978627
143glycoprotein catabolic process (GO:0006516)2.62124270
144anterior/posterior axis specification, embryo (GO:0008595)2.61464669
145cell adhesion mediated by integrin (GO:0033627)2.61419282
146galactose metabolic process (GO:0006012)2.60789169
147negative regulation of sodium ion transport (GO:0010766)2.58918683
148regulation of translation, ncRNA-mediated (GO:0045974)2.57946572
149negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.57946572
150negative regulation of translation, ncRNA-mediated (GO:0040033)2.57946572
151regulation of sarcomere organization (GO:0060297)2.56725638
152response to X-ray (GO:0010165)2.56027418
153glomerular visceral epithelial cell development (GO:0072015)2.54860452
154negative regulation of protein localization to cell surface (GO:2000009)2.54771642
155cilium organization (GO:0044782)2.54687974
156endosome to pigment granule transport (GO:0043485)2.53709442
157endosome to melanosome transport (GO:0035646)2.53709442
158hemidesmosome assembly (GO:0031581)2.53672816
159cilium assembly (GO:0042384)2.51858148
160positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)2.50756662
161motile cilium assembly (GO:0044458)2.47861854
162protein prenylation (GO:0018342)2.47059277
163prenylation (GO:0097354)2.47059277
164endocardial cushion development (GO:0003197)2.43487623
165rRNA catabolic process (GO:0016075)2.42851667
166Golgi to endosome transport (GO:0006895)2.41839034
167microtubule anchoring (GO:0034453)2.40469343
168negative regulation of DNA repair (GO:0045738)2.40089939
169cellular response to sterol (GO:0036315)2.39521459
170lymphangiogenesis (GO:0001946)2.38888410
171cilium morphogenesis (GO:0060271)2.34731129
172protein K11-linked deubiquitination (GO:0035871)2.33881831
173establishment of nucleus localization (GO:0040023)2.33639941
174iron ion import (GO:0097286)2.33140993
175regulation of membrane lipid distribution (GO:0097035)2.32402065
176smooth muscle tissue development (GO:0048745)2.30718654
177kynurenine metabolic process (GO:0070189)2.28775073
178histone-serine phosphorylation (GO:0035404)2.28010345
179photoreceptor cell maintenance (GO:0045494)2.27929677
180axoneme assembly (GO:0035082)2.26332505
181gene silencing by RNA (GO:0031047)2.25825739
182negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)2.25696788
183replicative senescence (GO:0090399)2.25640791
184negative regulation of hormone biosynthetic process (GO:0032353)2.25015874
185sphingoid metabolic process (GO:0046519)2.24761039
186protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.24211834
187regulation of developmental pigmentation (GO:0048070)2.24005537
188protein K63-linked deubiquitination (GO:0070536)2.23618489
189acrosome assembly (GO:0001675)2.22799346
190paraxial mesoderm development (GO:0048339)2.21667445
191left/right axis specification (GO:0070986)2.21420615
192appendage development (GO:0048736)2.21053993
193limb development (GO:0060173)2.21053993

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.23715823
2CLOCK_20551151_ChIP-Seq_293T_Human3.57579370
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.30682945
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.11443461
5* CEBPD_23245923_ChIP-Seq_MEFs_Mouse3.10445151
6TRIM28_21343339_ChIP-Seq_HEK293_Human3.01201562
7SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse2.76237324
8* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.74735123
9GBX2_23144817_ChIP-Seq_PC3_Human2.74346864
10* SOX2_27498859_Chip-Seq_STOMACH_Mouse2.72331591
11TP63_17297297_ChIP-ChIP_HaCaT_Human2.70133686
12ZNF263_19887448_ChIP-Seq_K562_Human2.62022820
13GATA1_22025678_ChIP-Seq_K562_Human2.55236230
14SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.55170816
15GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.54917857
16STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.53958252
17AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.43552146
18ESR2_21235772_ChIP-Seq_MCF-7_Human2.37602248
19ZFP57_27257070_Chip-Seq_ESCs_Mouse2.34338004
20SOX2_20726797_ChIP-Seq_SW620_Human2.32724524
21PIAS1_25552417_ChIP-Seq_VCAP_Human2.30527732
22ESR1_21235772_ChIP-Seq_MCF-7_Human2.29918669
23TAF15_26573619_Chip-Seq_HEK293_Human2.29836827
24SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.29375551
25AR_21915096_ChIP-Seq_LNCaP-1F5_Human2.28511858
26ZNF217_24962896_ChIP-Seq_MCF-7_Human2.25526183
27AR_21909140_ChIP-Seq_LNCAP_Human2.23054520
28SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.17449811
29SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.17449811
30FUS_26573619_Chip-Seq_HEK293_Human2.14990528
31FLI1_27457419_Chip-Seq_LIVER_Mouse2.14051822
32KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human2.09806790
33FOXO3_23340844_ChIP-Seq_DLD1_Human2.09549884
34FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human2.08564996
35GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.06882235
36EWS_26573619_Chip-Seq_HEK293_Human2.05401881
37CHD1_26751641_Chip-Seq_LNCaP_Human2.00975194
38SMAD_19615063_ChIP-ChIP_OVARY_Human1.99616010
39VDR_22108803_ChIP-Seq_LS180_Human1.97026525
40STAT3_23295773_ChIP-Seq_U87_Human1.95038852
41RARG_19884340_ChIP-ChIP_MEFs_Mouse1.93947646
42ESR1_20079471_ChIP-ChIP_T-47D_Human1.93281000
43ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.92360100
44IGF1R_20145208_ChIP-Seq_DFB_Human1.88894653
45* SMAD4_21799915_ChIP-Seq_A2780_Human1.87622015
46TP53_16413492_ChIP-PET_HCT116_Human1.87092688
47* P300_19829295_ChIP-Seq_ESCs_Human1.86027019
48PCGF2_27294783_Chip-Seq_ESCs_Mouse1.85030626
49GATA6_25053715_ChIP-Seq_YYC3_Human1.83774692
50TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.82162121
51HIF1A_21447827_ChIP-Seq_MCF-7_Human1.81421724
52* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.80105064
53CDX2_19796622_ChIP-Seq_MESCs_Mouse1.79821802
54TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.78178438
55PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.78159340
56PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.77293224
57RBPJ_22232070_ChIP-Seq_NCS_Mouse1.76485225
58PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.74233276
59TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.73997019
60ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.73471723
61MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.72759404
62GATA4_25053715_ChIP-Seq_YYC3_Human1.69344205
63* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.63038147
64GATA3_24758297_ChIP-Seq_MCF-7_Human1.62447432
65STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.62061622
66ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.61997286
67ER_23166858_ChIP-Seq_MCF-7_Human1.61739765
68OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.61270596
69CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.60438826
70SMAD3_21741376_ChIP-Seq_EPCs_Human1.60436851
71TCF4_23295773_ChIP-Seq_U87_Human1.59605067
72PKCTHETA_26484144_Chip-Seq_BREAST_Human1.59575557
73RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.58073483
74ATF3_27146783_Chip-Seq_COLON_Human1.56365612
75AHR_22903824_ChIP-Seq_MCF-7_Human1.56124031
76TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.55661945
77CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.55300372
78CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.55050200
79ZNF274_21170338_ChIP-Seq_K562_Hela1.54122948
80RUNX1_27514584_Chip-Seq_MCF-7_Human1.53698334
81DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.53183190
82SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.51475635
83STAT6_21828071_ChIP-Seq_BEAS2B_Human1.50257205
84* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.49176546
85BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.48485066
86NRF2_20460467_ChIP-Seq_MEFs_Mouse1.48191097
87NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.48191097
88BRD4_25478319_ChIP-Seq_HGPS_Human1.47137180
89KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.46936107
90KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.46936107
91KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.46936107
92SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.46602644
93* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.45803326
94CJUN_26792858_Chip-Seq_BT549_Human1.45109052
95PCGF2_27294783_Chip-Seq_NPCs_Mouse1.44673268
96AR_21572438_ChIP-Seq_LNCaP_Human1.44541601
97UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.44111161
98TP53_18474530_ChIP-ChIP_U2OS_Human1.43345988
99TOP2B_26459242_ChIP-Seq_MCF-7_Human1.41555056
100FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.41212233
101PPAR_26484153_Chip-Seq_NCI-H1993_Human1.40761707
102ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.39452566
103EZH2_27294783_Chip-Seq_NPCs_Mouse1.39050198
104NANOG_18555785_Chip-Seq_ESCs_Mouse1.38831491
105SUZ12_27294783_Chip-Seq_NPCs_Mouse1.38024095
106ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.37646455
107ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.35106494
108BCAT_22108803_ChIP-Seq_LS180_Human1.33641416
109P300_27058665_Chip-Seq_ZR-75-30cells_Human1.33443884
110WT1_19549856_ChIP-ChIP_CCG9911_Human1.32383723
111CDX2_22108803_ChIP-Seq_LS180_Human1.31114275
112CTBP1_25329375_ChIP-Seq_LNCAP_Human1.30780827
113ARNT_22903824_ChIP-Seq_MCF-7_Human1.30293935
114FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.30254098
115* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.29802338
116SOX9_24532713_ChIP-Seq_HFSC_Mouse1.29201681
117CBP_20019798_ChIP-Seq_JUKART_Human1.28873926
118IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.28873926
119CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.28838362
120AR_25329375_ChIP-Seq_VCAP_Human1.28778617
121* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.28718525
122TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.28170292
123TCF4_18268006_ChIP-ChIP_LS174T_Human1.27949677
124FOXA1_25552417_ChIP-Seq_VCAP_Human1.26699404
125* TP63_23658742_ChIP-Seq_EP156T_Human1.25580171
126TCF4_22108803_ChIP-Seq_LS180_Human1.25538285
127E2F1_18555785_Chip-Seq_ESCs_Mouse1.24691505
128EP300_21415370_ChIP-Seq_HL-1_Mouse1.24462843
129KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.24031054
130RUNX2_22187159_ChIP-Seq_PCA_Human1.23717339
131TBX3_20139965_ChIP-Seq_ESCs_Mouse1.23395095
132POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.23155121
133TBX3_20139965_ChIP-Seq_MESCs_Mouse1.22640968
134NFE2_27457419_Chip-Seq_LIVER_Mouse1.19418276
135WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.19335878
136SMAD3_21741376_ChIP-Seq_HESCs_Human1.18825053
137FOXA2_19822575_ChIP-Seq_HepG2_Human1.17799216
138RACK7_27058665_Chip-Seq_MCF-7_Human1.17598625
139TP53_22127205_ChIP-Seq_IMR90_Human1.17299198
140TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.17242861
141CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.16298957
142STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.15851857
143FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.15443558
144* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.14844881
145GATA2_21666600_ChIP-Seq_HMVEC_Human1.14806665
146ELF5_23300383_ChIP-Seq_T47D_Human1.13980569
147* P53_22387025_ChIP-Seq_ESCs_Mouse1.13529804
148FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.13264595
149SALL1_21062744_ChIP-ChIP_HESCs_Human1.13153034
150CTNNB1_20460455_ChIP-Seq_HCT116_Human1.13105047
151FLI1_21867929_ChIP-Seq_TH2_Mouse1.13105035
152CREB1_26743006_Chip-Seq_LNCaP_Human1.13087736
153YAP1_20516196_ChIP-Seq_MESCs_Mouse1.12389830
154ZFX_18555785_ChIP-Seq_MESCs_Mouse1.12176357
155TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11638538
156FOXM1_26456572_ChIP-Seq_MCF-7_Human1.11116282
157CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.10750590
158SOX2_21211035_ChIP-Seq_LN229_Gbm1.10558078
159* CMYC_18555785_Chip-Seq_ESCs_Mouse1.10517336
160UBF1/2_26484160_Chip-Seq_HMECs_Human1.08551818
161SMAD4_21741376_ChIP-Seq_EPCs_Human1.08336343
162FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.07339002
163KDM2B_26808549_Chip-Seq_REH_Human1.06935725
164* MYC_22102868_ChIP-Seq_BL_Human1.06462991
165* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.06374307
166KLF5_20875108_ChIP-Seq_MESCs_Mouse1.05992442
167* P300_18555785_Chip-Seq_ESCs_Mouse1.04916741
168NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.04539959
169* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.04529641
170BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.04184681
171CRX_20693478_ChIP-Seq_RETINA_Mouse1.04081005
172TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04003481
173POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.04003481
174TFEB_21752829_ChIP-Seq_HELA_Human1.01821259
175PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01287489
176STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.01054357
177TBX20_22080862_ChIP-Seq_HEART_Mouse1.00931182
178TBX20_22328084_ChIP-Seq_HEART_Mouse1.00931182
179CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.99800001
180JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.99159376

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle5.44024144
2MP0008057_abnormal_DNA_replication4.96457306
3MP0003300_gastrointestinal_ulcer4.43918028
4MP0002166_altered_tumor_susceptibility4.06125059
5MP0008438_abnormal_cutaneous_collagen3.99696121
6MP0010386_abnormal_urinary_bladder3.37782864
7MP0000537_abnormal_urethra_morphology3.12396415
8MP0002006_tumorigenesis2.91513924
9MP0003705_abnormal_hypodermis_morpholog2.84195161
10MP0003941_abnormal_skin_development2.78013445
11MP0000383_abnormal_hair_follicle2.77450702
12MP0010352_gastrointestinal_tract_polyps2.74387141
13MP0006054_spinal_hemorrhage2.72348172
14MP0009780_abnormal_chondrocyte_physiolo2.53157814
15MP0010368_abnormal_lymphatic_system2.38801027
16MP0005275_abnormal_skin_tensile2.30564705
17* MP0005310_abnormal_salivary_gland2.27403552
18MP0003950_abnormal_plasma_membrane2.22089447
19MP0004043_abnormal_pH_regulation2.19142235
20MP0000613_abnormal_salivary_gland2.17436232
21MP0005647_abnormal_sex_gland2.14209181
22MP0003183_abnormal_peptide_metabolism2.01809091
23MP0004264_abnormal_extraembryonic_tissu2.01285076
24MP0004272_abnormal_basement_membrane1.97905879
25MP0001873_stomach_inflammation1.93661138
26MP0005058_abnormal_lysosome_morphology1.85906779
27MP0002009_preneoplasia1.81735220
28MP0001765_abnormal_ion_homeostasis1.81445018
29MP0000427_abnormal_hair_cycle1.78561856
30MP0005503_abnormal_tendon_morphology1.71656303
31MP0001299_abnormal_eye_distance/1.71203364
32MP0005220_abnormal_exocrine_pancreas1.66849082
33MP0001756_abnormal_urination1.65132499
34MP0005076_abnormal_cell_differentiation1.61468534
35MP0003566_abnormal_cell_adhesion1.60101343
36MP0002877_abnormal_melanocyte_morpholog1.59000169
37MP0009384_cardiac_valve_regurgitation1.57767665
38MP0002295_abnormal_pulmonary_circulatio1.56545229
39MP0002168_other_aberrant_phenotype1.53659502
40MP0000428_abnormal_craniofacial_morphol1.52451634
41MP0000534_abnormal_ureter_morphology1.47719042
42MP0002084_abnormal_developmental_patter1.46262133
43MP0002896_abnormal_bone_mineralization1.44210603
44MP0001958_emphysema1.41567169
45MP0003283_abnormal_digestive_organ1.39667029
46MP0005023_abnormal_wound_healing1.38300624
47MP0003195_calcinosis1.34412830
48MP0003943_abnormal_hepatobiliary_system1.34279950
49MP0009697_abnormal_copulation1.33737034
50MP0000538_abnormal_urinary_bladder1.32983948
51MP0003045_fibrosis1.27657891
52MP0003984_embryonic_growth_retardation1.24654486
53MP0005623_abnormal_meninges_morphology1.24558356
54MP0002088_abnormal_embryonic_growth/wei1.23447619
55MP0003385_abnormal_body_wall1.21881173
56MP0003935_abnormal_craniofacial_develop1.21597343
57MP0002909_abnormal_adrenal_gland1.18458669
58MP0000432_abnormal_head_morphology1.18447136
59MP0001944_abnormal_pancreas_morphology1.17755864
60MP0001672_abnormal_embryogenesis/_devel1.17473720
61MP0005380_embryogenesis_phenotype1.17473720
62MP0010094_abnormal_chromosome_stability1.15065940
63MP0004084_abnormal_cardiac_muscle1.13528215
64MP0002697_abnormal_eye_size1.12828053
65MP0000516_abnormal_urinary_system1.11019173
66MP0005367_renal/urinary_system_phenotyp1.11019173
67MP0003868_abnormal_feces_composition1.10590269
68MP0005395_other_phenotype1.10175792
69MP0003866_abnormal_defecation1.07085654
70MP0009703_decreased_birth_body1.07048946
71MP0010678_abnormal_skin_adnexa1.04289599
72MP0002086_abnormal_extraembryonic_tissu1.03838784
73MP0001661_extended_life_span1.03761348
74MP0002109_abnormal_limb_morphology1.02972371
75MP0003119_abnormal_digestive_system1.02049401
76MP0003115_abnormal_respiratory_system1.01785064
77MP0004134_abnormal_chest_morphology0.99088477
78MP0000013_abnormal_adipose_tissue0.98436322
79MP0004808_abnormal_hematopoietic_stem0.98246082
80MP0001915_intracranial_hemorrhage0.97843627
81MP0003091_abnormal_cell_migration0.97046236
82MP0009643_abnormal_urine_homeostasis0.95606426
83MP0002233_abnormal_nose_morphology0.95388632
84MP0003755_abnormal_palate_morphology0.94606193
85MP0002085_abnormal_embryonic_tissue0.93937226
86MP0001346_abnormal_lacrimal_gland0.93645343
87MP0000767_abnormal_smooth_muscle0.93059247
88MP0009764_decreased_sensitivity_to0.92683647
89MP0005636_abnormal_mineral_homeostasis0.91141352
90MP0000647_abnormal_sebaceous_gland0.91110860
91MP0003252_abnormal_bile_duct0.90284096
92MP0002060_abnormal_skin_morphology0.90201019
93MP0001286_abnormal_eye_development0.89754851
94MP0001293_anophthalmia0.89443754
95MP0002396_abnormal_hematopoietic_system0.86511659
96MP0002938_white_spotting0.86481860
97MP0004782_abnormal_surfactant_physiolog0.86079188
98MP0000681_abnormal_thyroid_gland0.84055810
99MP0003279_aneurysm0.83696625
100MP0003942_abnormal_urinary_system0.81503774
101MP0000627_abnormal_mammary_gland0.80566511
102MP0002111_abnormal_tail_morphology0.80456032
103MP0000462_abnormal_digestive_system0.80335542
104MP0002135_abnormal_kidney_morphology0.80012915
105MP0010155_abnormal_intestine_physiology0.79088864
106MP0000371_diluted_coat_color0.78919788
107MP0008007_abnormal_cellular_replicative0.78418514
108MP0002160_abnormal_reproductive_system0.77388482
109MP0002136_abnormal_kidney_physiology0.76727907
110MP0000163_abnormal_cartilage_morphology0.76609804
111MP0002693_abnormal_pancreas_physiology0.76135780
112MP0001984_abnormal_olfaction0.76058051
113MP0004133_heterotaxia0.75792813
114MP0002115_abnormal_skeleton_extremities0.75786359
115MP0001177_atelectasis0.75458341
116MP0003890_abnormal_embryonic-extraembry0.75454298
117MP0002092_abnormal_eye_morphology0.75345035
118MP0000266_abnormal_heart_morphology0.74947965
119MP0002128_abnormal_blood_circulation0.74735628
120MP0002102_abnormal_ear_morphology0.74645029
121MP0008961_abnormal_basal_metabolism0.74431118
122MP0001697_abnormal_embryo_size0.74111036
123MP0009053_abnormal_anal_canal0.72827927
124MP0002234_abnormal_pharynx_morphology0.72098993
125MP0005187_abnormal_penis_morphology0.71900621
126MP0009250_abnormal_appendicular_skeleto0.71260820
127MP0002108_abnormal_muscle_morphology0.70185693
128MP0010307_abnormal_tumor_latency0.70161013
129MP0001614_abnormal_blood_vessel0.70040622
130MP0004215_abnormal_myocardial_fiber0.69470552
131MP0001784_abnormal_fluid_regulation0.69284311
132MP0002113_abnormal_skeleton_development0.68959312
133MP0003632_abnormal_nervous_system0.67876450
134MP0000477_abnormal_intestine_morphology0.66986226
135MP0002928_abnormal_bile_duct0.66942034
136MP0005379_endocrine/exocrine_gland_phen0.66736164
137MP0003656_abnormal_erythrocyte_physiolo0.66100074
138MP0000003_abnormal_adipose_tissue0.65970193
139MP0008775_abnormal_heart_ventricle0.65940055
140MP0003718_maternal_effect0.65437392
141MP0000569_abnormal_digit_pigmentation0.65282322
142MP0004947_skin_inflammation0.65210702
143MP0005391_vision/eye_phenotype0.65160171
144MP0009765_abnormal_xenobiotic_induced0.64980081
145MP0003795_abnormal_bone_structure0.62491020
146MP0004233_abnormal_muscle_weight0.61444180
147MP0000733_abnormal_muscle_development0.61360821
148MP0005408_hypopigmentation0.61329715
149MP0005166_decreased_susceptibility_to0.61245079
150MP0003315_abnormal_perineum_morphology0.61161474
151MP0005508_abnormal_skeleton_morphology0.60268319
152MP0003937_abnormal_limbs/digits/tail_de0.59158751
153MP0000490_abnormal_crypts_of0.58094786
154MP0002925_abnormal_cardiovascular_devel0.56375450
155MP0005257_abnormal_intraocular_pressure0.55288710
156MP0004197_abnormal_fetal_growth/weight/0.55077358
157MP0002163_abnormal_gland_morphology0.54257576
158MP0003959_abnormal_lean_body0.53904479
159MP0003936_abnormal_reproductive_system0.53263416
160MP0004185_abnormal_adipocyte_glucose0.53244584
161MP0001879_abnormal_lymphatic_vessel0.53220662
162MP0001348_abnormal_lacrimal_gland0.52742648

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cochlea (HP:0000375)5.45748777
2Aortic aneurysm (HP:0004942)4.86738735
3Aortic dissection (HP:0002647)3.83919796
4Cervical subluxation (HP:0003308)3.72802032
5Genetic anticipation (HP:0003743)3.51828850
6Vacuolated lymphocytes (HP:0001922)3.40826132
7Morphological abnormality of the inner ear (HP:0011390)3.40210875
8Cerebral aneurysm (HP:0004944)3.26974941
9Urinary glycosaminoglycan excretion (HP:0003541)3.16282787
10Mucopolysacchariduria (HP:0008155)3.16282787
11Thoracolumbar scoliosis (HP:0002944)3.09558209
12Protrusio acetabuli (HP:0003179)2.97255972
13Rectal prolapse (HP:0002035)2.95545504
14Aneurysm (HP:0002617)2.94286743
15Abnormal ciliary motility (HP:0012262)2.93712364
16Dynein arm defect of respiratory motile cilia (HP:0012255)2.93331750
17Absent/shortened dynein arms (HP:0200106)2.93331750
18Protruding tongue (HP:0010808)2.92348926
19Dysostosis multiplex (HP:0000943)2.81844139
20Rhinitis (HP:0012384)2.78397787
21Abnormality of the intrinsic pathway (HP:0010989)2.74475792
22Abnormality of polysaccharide metabolism (HP:0011012)2.73799934
23Abnormality of glycosaminoglycan metabolism (HP:0004371)2.73799934
24Abnormality of mucopolysaccharide metabolism (HP:0011020)2.73799934
25Ankle contracture (HP:0006466)2.71428925
26Pancreatic cysts (HP:0001737)2.70163436
27Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.70153415
28Thrombocytosis (HP:0001894)2.69734735
29Abnormal respiratory motile cilium physiology (HP:0012261)2.68938273
30Hand muscle atrophy (HP:0009130)2.67432894
31Gaze-evoked nystagmus (HP:0000640)2.64511868
32Abnormal respiratory motile cilium morphology (HP:0005938)2.64469241
33Abnormal respiratory epithelium morphology (HP:0012253)2.64469241
34Abnormality of the 2nd finger (HP:0004100)2.64243793
35Subacute progressive viral hepatitis (HP:0006572)2.56719848
36Pancreatic fibrosis (HP:0100732)2.53538085
37Chronic hepatic failure (HP:0100626)2.50256187
38Osteolytic defects of the hand bones (HP:0009699)2.45141475
39Osteolytic defects of the phalanges of the hand (HP:0009771)2.45141475
40Abnormal foot bone ossification (HP:0010675)2.44515191
41Aplasia/Hypoplasia of the tibia (HP:0005772)2.43784298
42Hematochezia (HP:0002573)2.42727334
43Dysmetric saccades (HP:0000641)2.41840732
44Potter facies (HP:0002009)2.41014413
45Facial shape deformation (HP:0011334)2.41014413
46Premature rupture of membranes (HP:0001788)2.40725369
47Aplasia involving bones of the upper limbs (HP:0009823)2.40633474
48Aplasia of the phalanges of the hand (HP:0009802)2.40633474
49Aplasia involving bones of the extremities (HP:0009825)2.40633474
50Long toe (HP:0010511)2.40619795
51True hermaphroditism (HP:0010459)2.39145585
52Hypoplasia of the pons (HP:0012110)2.38812003
53Preaxial foot polydactyly (HP:0001841)2.38561232
54Dilatation of the ascending aorta (HP:0005111)2.35043676
55Fair hair (HP:0002286)2.34253117
56Radial bowing (HP:0002986)2.33466367
57Exocrine pancreatic insufficiency (HP:0001738)2.32509064
58Subcapsular cataract (HP:0000523)2.30487611
59Atrophic scars (HP:0001075)2.30452285
60Hyperventilation (HP:0002883)2.30428189
61Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.30281860
62Abnormality of the ischium (HP:0003174)2.30235159
63Wormian bones (HP:0002645)2.27922251
64Abnormality of oral frenula (HP:0000190)2.27223572
65Beaking of vertebral bodies (HP:0004568)2.26447126
66Shallow orbits (HP:0000586)2.22384991
67Coxa valga (HP:0002673)2.22179542
68Increased density of long bones (HP:0006392)2.22074667
69Papillary thyroid carcinoma (HP:0002895)2.21784490
70Chronic bronchitis (HP:0004469)2.20231675
71Central scotoma (HP:0000603)2.19357051
72Distal upper limb amyotrophy (HP:0007149)2.18727341
73Upper limb amyotrophy (HP:0009129)2.18727341
74Abnormality of the proximal phalanges of the hand (HP:0009834)2.17107035
75Aortic regurgitation (HP:0001659)2.16963047
76Tubulointerstitial nephritis (HP:0001970)2.15958988
77Molar tooth sign on MRI (HP:0002419)2.10521299
78Abnormality of midbrain morphology (HP:0002418)2.10521299
79Hypoplasia of the uterus (HP:0000013)2.10025402
80Cystic liver disease (HP:0006706)2.05728159
81Macroorchidism (HP:0000053)2.05020422
82Buphthalmos (HP:0000557)2.04863226
83Chromsome breakage (HP:0040012)2.04392724
84Volvulus (HP:0002580)2.03373410
85Abnormality of the renal medulla (HP:0100957)2.03260927
86Tubular atrophy (HP:0000092)2.02159292
87Bronchiectasis (HP:0002110)2.01952451
88Mildly elevated creatine phosphokinase (HP:0008180)2.01678075
89Short hallux (HP:0010109)2.01641028
90Abnormality of the pons (HP:0007361)2.00555083
91Back pain (HP:0003418)2.00096309
92Enlarged penis (HP:0000040)1.99993747
93Fibular aplasia (HP:0002990)1.99614541
94Micronodular cirrhosis (HP:0001413)1.97717639
95Mitral valve prolapse (HP:0001634)1.97695731
96Camptodactyly of toe (HP:0001836)1.97498074
97Hypoplastic ischia (HP:0003175)1.97226860
98Abnormal biliary tract morphology (HP:0012440)1.97092205
99Severe short stature (HP:0003510)1.96847354
100Nephronophthisis (HP:0000090)1.95005484
101Biliary tract neoplasm (HP:0100574)1.94719249
102Abnormality of the renal cortex (HP:0011035)1.94605361
103Ankyloglossia (HP:0010296)1.94598104
104Sparse lateral eyebrow (HP:0005338)1.93578824
105Ulnar deviation of the wrist (HP:0003049)1.91709213
106Ulnar bowing (HP:0003031)1.91155873
107Medial flaring of the eyebrow (HP:0010747)1.91024129
108Abnormality of dentin (HP:0010299)1.90528864
109Aplasia/Hypoplasia of the tongue (HP:0010295)1.89874998
110Hypoplastic nipples (HP:0002557)1.89065352
111Hypopigmentation of the fundus (HP:0007894)1.88775759
112Arterial tortuosity (HP:0005116)1.88249162
113Chromosomal breakage induced by crosslinking agents (HP:0003221)1.88196147
114Shawl scrotum (HP:0000049)1.88027386
115Hypoplastic labia majora (HP:0000059)1.86916908
116Deviation of the hallux (HP:0010051)1.85466291
117Short humerus (HP:0005792)1.85231908
118Abnormality of the calcaneus (HP:0008364)1.85052856
119Bicuspid aortic valve (HP:0001647)1.84629532
120Postaxial foot polydactyly (HP:0001830)1.84056293
121Abdominal distention (HP:0003270)1.83956016
122Aplasia/Hypoplasia of the hallux (HP:0008362)1.83577089
123Limb-girdle muscle atrophy (HP:0003797)1.82044386
124Persistence of primary teeth (HP:0006335)1.81600223
125Widely spaced teeth (HP:0000687)1.80672023
126Short foot (HP:0001773)1.80625358
127Vascular tortuosity (HP:0004948)1.79732925
128Genital tract atresia (HP:0001827)1.77219303
129Achilles tendon contracture (HP:0001771)1.76975724
130Acute myeloid leukemia (HP:0004808)1.76675194
131Broad metatarsal (HP:0001783)1.76530687
132Papilledema (HP:0001085)1.75295419
133Scapular winging (HP:0003691)1.74811034
134Right ventricular cardiomyopathy (HP:0011663)1.74510936
135Congenital primary aphakia (HP:0007707)1.74201600
136Generalized hypopigmentation of hair (HP:0011358)1.73747103
137Poor coordination (HP:0002370)1.73318560
138Abnormality of the odontoid process (HP:0003310)1.72909480
139Hyperkalemia (HP:0002153)1.72815535
140Sandal gap (HP:0001852)1.72170467
141Soft skin (HP:0000977)1.72159960
142Absent frontal sinuses (HP:0002688)1.71635318
143Vaginal atresia (HP:0000148)1.71441847
144Hallux valgus (HP:0001822)1.70269678
145Scotoma (HP:0000575)1.69662826
146Clumsiness (HP:0002312)1.69182708
147Drooling (HP:0002307)1.68874654
148Tarsal synostosis (HP:0008368)1.68032092
149Absent radius (HP:0003974)1.67839776
150Overgrowth (HP:0001548)1.66488973
151Progressive cerebellar ataxia (HP:0002073)1.65739401
152Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.64380573
153Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.64369728
154Abnormality of the nasal septum (HP:0000419)1.63712381
155Lymphangioma (HP:0100764)1.63632722
156Abnormality of the labia majora (HP:0012881)1.61975580
157Cutaneous finger syndactyly (HP:0010554)1.61051951
158Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.60828999
159Hypoplastic scapulae (HP:0000882)1.60734675
160Aplasia/Hypoplasia of the scapulae (HP:0006713)1.60734675
161Bowel diverticulosis (HP:0005222)1.60455331
162Abnormality of proline metabolism (HP:0010907)1.59873786
163Hydroxyprolinuria (HP:0003080)1.59873786
164Asymmetry of the thorax (HP:0001555)1.59701476
165Absent speech (HP:0001344)1.59038196
166Bifid tongue (HP:0010297)1.58940208
167Abnormality of chromosome stability (HP:0003220)1.58332742
168Gait imbalance (HP:0002141)1.57488593
169Abnormality of the astrocytes (HP:0100707)1.56360284
170Astrocytoma (HP:0009592)1.56360284
171Increased number of teeth (HP:0011069)1.55677736
172Preaxial hand polydactyly (HP:0001177)1.55656349
173Neoplasm of the small intestine (HP:0100833)1.54700015
174Curly hair (HP:0002212)1.53973688
175Highly arched eyebrow (HP:0002553)1.53934179
176Aplasia involving forearm bones (HP:0009822)1.53517605
177Absent forearm bone (HP:0003953)1.53517605
178Abnormality of the epiphyses of the hand (HP:0005924)1.51617943
179Pulmonic stenosis (HP:0001642)1.51473160
180Thick eyebrow (HP:0000574)1.50864141
181Cupped ear (HP:0000378)1.50570346
182Tracheomalacia (HP:0002779)1.50434593
183Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.50008121
184Short chin (HP:0000331)1.49591104
185Capillary hemangiomas (HP:0005306)1.49447747
186Congenital hepatic fibrosis (HP:0002612)1.48714097
187Cone-rod dystrophy (HP:0000548)1.48676386
188Bronchomalacia (HP:0002780)1.48307927
189Occipital encephalocele (HP:0002085)1.47385729

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.50371203
2AKT35.27952794
3ERN13.80189872
4MST43.64436884
5TAOK33.55103686
6SCYL23.49345567
7ACVR1B3.34333092
8LATS13.26151844
9EEF2K3.05813250
10TTN2.74728293
11MKNK22.68588913
12BMPR1B2.52905506
13STK392.52762208
14STK38L2.47232420
15TRIB32.42098157
16MAP3K22.39119227
17SIK12.02763398
18MKNK11.99562086
19PKN21.91522736
20PTK61.81390702
21TIE11.80601503
22LRRK21.79515842
23PNCK1.74027928
24LMTK21.67043303
25EPHA21.66697353
26MYLK1.63296122
27PDGFRA1.61874858
28TESK11.61810494
29CDK121.61548588
30BCR1.58328755
31CAMK1G1.54145971
32BCKDK1.42398223
33NUAK11.41283986
34DDR21.36158539
35CASK1.35687792
36FER1.33680487
37STK101.32482449
38ERBB31.31531912
39RPS6KB21.25674427
40PDK21.25405555
41TEC1.22253489
42MAPKAPK31.14822505
43PIK3CG1.10508321
44OXSR11.07490453
45STK31.06438886
46PAK21.05176595
47ERBB41.01198143
48PIK3CA1.00676778
49MAP3K40.99857914
50CAMK1D0.99248098
51JAK30.94824389
52TGFBR10.94493538
53PASK0.93689500
54INSRR0.93270058
55RIPK10.92837493
56STK240.91270093
57DMPK0.90399658
58TTK0.89741090
59TRPM70.88413629
60BRSK20.88013920
61RPS6KA20.83152525
62TESK20.82743660
63NLK0.80678287
64PRKCE0.77910871
65MAP3K30.77670537
66STK380.77464621
67GRK10.76468453
68PTK20.75957411
69MET0.72844940
70NEK20.71659333
71PLK20.70222997
72FLT30.68577088
73MAPK150.65601920
74KSR20.65282685
75NTRK10.64964331
76TNK20.64665619
77PRKAA20.64487066
78MAP3K80.64214632
79ATM0.63074247
80MAP2K20.62748404
81RET0.61679763
82PTK2B0.61523205
83JAK10.61328483
84KSR10.61234000
85PLK40.61179537
86TNIK0.60538461
87TAF10.59640066
88YES10.59097490
89TRIM280.58292909
90WNK30.57422423
91PBK0.55609110
92LIMK10.55087752
93ERBB20.54623145
94PRKCI0.54264800
95JAK20.53757563
96SGK20.52934448
97MTOR0.52914338
98CSNK1A1L0.51775087
99MAP2K30.51119027
100EIF2AK30.49966011
101TSSK60.49863622
102CHEK20.49278386
103NEK90.49269985
104ROCK10.48126481
105ROCK20.47310893
106WNK10.45993087
107WEE10.45970510
108PAK40.45405849
109MAP3K70.44530853
110NTRK30.44444884
111MELK0.43796709
112CAMKK10.43476765
113LATS20.43104447
114MST1R0.43050916
115PAK30.42886009
116PDGFRB0.41820340
117CSF1R0.40114518
118EIF2AK20.39913206
119ATR0.39778789
120FGFR20.39563983
121TGFBR20.37651020
122PRKAA10.37168186
123MAP4K20.36332629
124CSNK1G10.36088758
125CHEK10.35818428
126PDK30.35634984
127PDK40.35634984
128CSNK1D0.34348548
129ILK0.31455885
130IGF1R0.31391439
131TYK20.31346442
132RPS6KC10.31251791
133RPS6KL10.31251791
134BMX0.31249222
135PLK30.30733161
136EGFR0.30584644
137PLK10.30048639
138CDK60.29759122
139FGFR30.27697282
140CAMKK20.26784937
141MAP2K10.23613905
142ADRBK10.22228684
143INSR0.22045453
144RPS6KA60.19898412
145RPS6KB10.19808003
146HIPK20.19561962
147CDC42BPA0.19561547
148FGFR10.18243554
149PDK10.17794625
150BRD40.17386308
151WNK40.17305846
152AURKB0.17193702
153SRC0.15876562
154FYN0.15194149
155PRKCH0.14904407

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006034.45651690
2* Protein processing in endoplasmic reticulum_Homo sapiens_hsa041414.38025143
3Protein export_Homo sapiens_hsa030603.39017441
4Sulfur metabolism_Homo sapiens_hsa009202.96703382
5N-Glycan biosynthesis_Homo sapiens_hsa005102.92648801
6Vibrio cholerae infection_Homo sapiens_hsa051102.31797559
7Non-homologous end-joining_Homo sapiens_hsa034502.17039744
8Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.99501334
9Lysine degradation_Homo sapiens_hsa003101.93622791
10Renin-angiotensin system_Homo sapiens_hsa046141.90254235
11Focal adhesion_Homo sapiens_hsa045101.87245408
12ABC transporters_Homo sapiens_hsa020101.86776203
13ECM-receptor interaction_Homo sapiens_hsa045121.81455432
14Other glycan degradation_Homo sapiens_hsa005111.77387795
15Prostate cancer_Homo sapiens_hsa052151.77177736
16Small cell lung cancer_Homo sapiens_hsa052221.68190007
17Bladder cancer_Homo sapiens_hsa052191.67589261
18Adherens junction_Homo sapiens_hsa045201.54874892
19Thyroid hormone synthesis_Homo sapiens_hsa049181.51780710
20Amoebiasis_Homo sapiens_hsa051461.49151087
21Endometrial cancer_Homo sapiens_hsa052131.46976923
22Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.42935148
23Lysosome_Homo sapiens_hsa041421.36282221
24Tight junction_Homo sapiens_hsa045301.33369372
25Chronic myeloid leukemia_Homo sapiens_hsa052201.32777330
26AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.30914716
27Proteoglycans in cancer_Homo sapiens_hsa052051.29166263
28Leukocyte transendothelial migration_Homo sapiens_hsa046701.25476628
29Protein digestion and absorption_Homo sapiens_hsa049741.24869601
30Histidine metabolism_Homo sapiens_hsa003401.24418207
31Sphingolipid metabolism_Homo sapiens_hsa006001.23374924
32Fanconi anemia pathway_Homo sapiens_hsa034601.19546123
33Dorso-ventral axis formation_Homo sapiens_hsa043201.18627777
34Maturity onset diabetes of the young_Homo sapiens_hsa049501.18145759
35Glycosaminoglycan degradation_Homo sapiens_hsa005311.15465437
36Pancreatic cancer_Homo sapiens_hsa052121.13573153
37Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.13144919
38Butanoate metabolism_Homo sapiens_hsa006501.11100159
39Glioma_Homo sapiens_hsa052141.10681201
40p53 signaling pathway_Homo sapiens_hsa041151.10160841
41Taste transduction_Homo sapiens_hsa047421.09003000
42Hippo signaling pathway_Homo sapiens_hsa043901.08262121
43mTOR signaling pathway_Homo sapiens_hsa041501.07974036
44Antigen processing and presentation_Homo sapiens_hsa046121.07951089
45TGF-beta signaling pathway_Homo sapiens_hsa043501.06512861
46Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.05341660
47Fatty acid biosynthesis_Homo sapiens_hsa000611.03460160
48Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.02305255
49Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.01704974
50Steroid hormone biosynthesis_Homo sapiens_hsa001401.01286428
51Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.00739209
52Basal cell carcinoma_Homo sapiens_hsa052171.00733461
53Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.99549240
54Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.98148299
55Non-small cell lung cancer_Homo sapiens_hsa052230.97203588
56Hedgehog signaling pathway_Homo sapiens_hsa043400.96453156
57Estrogen signaling pathway_Homo sapiens_hsa049150.94659303
58Ether lipid metabolism_Homo sapiens_hsa005650.94184392
59Melanoma_Homo sapiens_hsa052180.93402049
60Circadian rhythm_Homo sapiens_hsa047100.93200166
61Propanoate metabolism_Homo sapiens_hsa006400.91726320
62Insulin resistance_Homo sapiens_hsa049310.86170563
63Thyroid cancer_Homo sapiens_hsa052160.85106090
64Nitrogen metabolism_Homo sapiens_hsa009100.84794995
65Toxoplasmosis_Homo sapiens_hsa051450.83427523
66Tryptophan metabolism_Homo sapiens_hsa003800.82284654
67Prolactin signaling pathway_Homo sapiens_hsa049170.81917456
68ErbB signaling pathway_Homo sapiens_hsa040120.81079365
69Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.80940753
70Hepatitis C_Homo sapiens_hsa051600.80660721
71Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.79475641
72Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.79113780
73Inositol phosphate metabolism_Homo sapiens_hsa005620.77601280
74Primary bile acid biosynthesis_Homo sapiens_hsa001200.77379508
75PI3K-Akt signaling pathway_Homo sapiens_hsa041510.76541864
76Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.76531813
77Pathways in cancer_Homo sapiens_hsa052000.76006624
78Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.75699489
79Basal transcription factors_Homo sapiens_hsa030220.74209380
80Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.73698181
81Long-term depression_Homo sapiens_hsa047300.73575447
82Serotonergic synapse_Homo sapiens_hsa047260.72061505
83Regulation of actin cytoskeleton_Homo sapiens_hsa048100.72047529
84Glycerolipid metabolism_Homo sapiens_hsa005610.70336150
85MicroRNAs in cancer_Homo sapiens_hsa052060.69895289
86Cell cycle_Homo sapiens_hsa041100.68877545
87Axon guidance_Homo sapiens_hsa043600.68543990
88Homologous recombination_Homo sapiens_hsa034400.68054057
89Platelet activation_Homo sapiens_hsa046110.67781599
90Fructose and mannose metabolism_Homo sapiens_hsa000510.67732437
91Salivary secretion_Homo sapiens_hsa049700.66275662
92Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.65532420
93Glutamatergic synapse_Homo sapiens_hsa047240.64279420
94Endocytosis_Homo sapiens_hsa041440.63970368
95beta-Alanine metabolism_Homo sapiens_hsa004100.63777282
96Retinol metabolism_Homo sapiens_hsa008300.62810489
97Dilated cardiomyopathy_Homo sapiens_hsa054140.62752389
98Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.62255332
99Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.62227283
100Gap junction_Homo sapiens_hsa045400.62170908
101Central carbon metabolism in cancer_Homo sapiens_hsa052300.61961610
102Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.61174874
103Neurotrophin signaling pathway_Homo sapiens_hsa047220.59461536
104Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.59421050
105Type II diabetes mellitus_Homo sapiens_hsa049300.59309775
106Vascular smooth muscle contraction_Homo sapiens_hsa042700.58698242
107Phagosome_Homo sapiens_hsa041450.58520544
108Legionellosis_Homo sapiens_hsa051340.57668514
109Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.57317067
110Thyroid hormone signaling pathway_Homo sapiens_hsa049190.56610781
111mRNA surveillance pathway_Homo sapiens_hsa030150.55994784
112Colorectal cancer_Homo sapiens_hsa052100.55737740
113Steroid biosynthesis_Homo sapiens_hsa001000.55641161
114Linoleic acid metabolism_Homo sapiens_hsa005910.55272378
115Viral carcinogenesis_Homo sapiens_hsa052030.54802339
116Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.54769009
117Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.54691748
118One carbon pool by folate_Homo sapiens_hsa006700.54664654
119Calcium signaling pathway_Homo sapiens_hsa040200.54531848
120Hepatitis B_Homo sapiens_hsa051610.54452783
121Insulin signaling pathway_Homo sapiens_hsa049100.54160247
122Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.53896917
123Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.53887794
124Chemical carcinogenesis_Homo sapiens_hsa052040.52504403
125AMPK signaling pathway_Homo sapiens_hsa041520.50226479
126HIF-1 signaling pathway_Homo sapiens_hsa040660.50042446
127FoxO signaling pathway_Homo sapiens_hsa040680.49874464
128Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.49568790
129Longevity regulating pathway - mammal_Homo sapiens_hsa042110.49370345
130Acute myeloid leukemia_Homo sapiens_hsa052210.48616478
131alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.48390059
132Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.48312802
133Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.48056669
134Ras signaling pathway_Homo sapiens_hsa040140.47783434
135Shigellosis_Homo sapiens_hsa051310.47521716
136Phototransduction_Homo sapiens_hsa047440.47195859
137Phosphatidylinositol signaling system_Homo sapiens_hsa040700.46561593
138Carbohydrate digestion and absorption_Homo sapiens_hsa049730.45318369
139Apoptosis_Homo sapiens_hsa042100.43915436
140Prion diseases_Homo sapiens_hsa050200.43353598
141Selenocompound metabolism_Homo sapiens_hsa004500.43128195
142TNF signaling pathway_Homo sapiens_hsa046680.42266932
143Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.41690971
144Wnt signaling pathway_Homo sapiens_hsa043100.40211989
145Influenza A_Homo sapiens_hsa051640.39759868
146Rap1 signaling pathway_Homo sapiens_hsa040150.39235694
147Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.38005208
148Pancreatic secretion_Homo sapiens_hsa049720.37845634
149Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.37698172
150Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.37348252
151Gastric acid secretion_Homo sapiens_hsa049710.36688053
152cGMP-PKG signaling pathway_Homo sapiens_hsa040220.36388657
153Choline metabolism in cancer_Homo sapiens_hsa052310.36354338

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »