DNAJC13

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the Dnaj protein family whose members act as co-chaperones of a partner heat-shock protein by binding to the latter and stimulating ATP hydrolysis. The encoded protein associates with the heat-shock protein Hsc70 and plays a role in clathrin-mediated endocytosis. It may also be involved in post-endocytic transport mechanisms via its associations with other proteins, including the sorting nexin SNX1. Mutations in this gene are associated with Parkinson's disease. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)6.04347420
2nuclear pore organization (GO:0006999)5.54835383
3pore complex assembly (GO:0046931)4.44607961
4pre-miRNA processing (GO:0031054)4.14500283
5mitotic sister chromatid cohesion (GO:0007064)4.13725064
6heterochromatin organization (GO:0070828)3.90124948
7NLS-bearing protein import into nucleus (GO:0006607)3.89632196
8cytoplasmic mRNA processing body assembly (GO:0033962)3.78964681
9regulation of RNA export from nucleus (GO:0046831)3.58567650
10regulation of protein polyubiquitination (GO:1902914)3.51579908
11skin morphogenesis (GO:0043589)3.50870508
12hypotonic response (GO:0006971)3.48129697
13positive regulation of SMAD protein import into nucleus (GO:0060391)3.42755011
14negative regulation of histone methylation (GO:0031061)3.34659848
15glucocorticoid receptor signaling pathway (GO:0042921)3.29096692
16phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.27652749
17positive regulation of mitotic sister chromatid separation (GO:1901970)3.17690847
18positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.17690847
19positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.17690847
20positive regulation of endothelial cell apoptotic process (GO:2000353)3.16201076
21iron ion import (GO:0097286)3.11269219
22COPII vesicle coating (GO:0048208)3.11000231
23regulation of nucleobase-containing compound transport (GO:0032239)3.10020586
24mitotic nuclear envelope disassembly (GO:0007077)3.08687208
25regulation of mitotic spindle organization (GO:0060236)3.08628016
26negative regulation of DNA repair (GO:0045738)3.07715997
27collagen fibril organization (GO:0030199)3.04170241
28regulation of translational fidelity (GO:0006450)3.00685202
29cellular response to interferon-alpha (GO:0035457)3.00580339
30nuclear envelope disassembly (GO:0051081)3.00346259
31membrane disassembly (GO:0030397)3.00346259
32regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.00146562
33corticosteroid receptor signaling pathway (GO:0031958)2.95125091
34peptidyl-lysine dimethylation (GO:0018027)2.94830943
35regulation of posttranscriptional gene silencing (GO:0060147)2.92570630
36regulation of gene silencing by miRNA (GO:0060964)2.92570630
37regulation of gene silencing by RNA (GO:0060966)2.92570630
38retina vasculature morphogenesis in camera-type eye (GO:0061299)2.92172982
39pericardium development (GO:0060039)2.91861562
40mRNA stabilization (GO:0048255)2.91416061
41RNA stabilization (GO:0043489)2.91416061
42cortical actin cytoskeleton organization (GO:0030866)2.86831814
43regulation of sister chromatid cohesion (GO:0007063)2.86781738
44regulation of histone H3-K9 methylation (GO:0051570)2.85970575
45regulation of SMAD protein import into nucleus (GO:0060390)2.85781862
46histone H2A monoubiquitination (GO:0035518)2.84407941
47hemidesmosome assembly (GO:0031581)2.84266587
48chromatin assembly (GO:0031497)2.83663949
49growth hormone receptor signaling pathway (GO:0060396)2.81806918
50apoptotic cell clearance (GO:0043277)2.81630993
51positive regulation of histone deacetylation (GO:0031065)2.81500281
52negative regulation of anoikis (GO:2000811)2.81214689
53cellular response to ethanol (GO:0071361)2.79839445
54substrate-dependent cell migration (GO:0006929)2.79749640
55hippo signaling (GO:0035329)2.79551164
56membrane raft organization (GO:0031579)2.78099945
57cell adhesion mediated by integrin (GO:0033627)2.76963366
58platelet-derived growth factor receptor signaling pathway (GO:0048008)2.76543662
59folic acid-containing compound biosynthetic process (GO:0009396)2.75803872
60lipid translocation (GO:0034204)2.73309519
61phospholipid translocation (GO:0045332)2.73309519
62DNA geometric change (GO:0032392)2.73055029
63determination of adult lifespan (GO:0008340)2.72050467
64negative regulation of skeletal muscle tissue development (GO:0048642)2.71498238
65DNA duplex unwinding (GO:0032508)2.71198914
66pathway-restricted SMAD protein phosphorylation (GO:0060389)2.70538466
67chondrocyte development (GO:0002063)2.70334518
68protein localization to kinetochore (GO:0034501)2.69878587
69regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.69397112
70regulation of translational termination (GO:0006449)2.68731812
71protein localization to endosome (GO:0036010)2.66411921
72mitotic chromosome condensation (GO:0007076)2.66374761
73pinocytosis (GO:0006907)2.66177867
74negative regulation of protein localization to plasma membrane (GO:1903077)2.65960299
75negative regulation of fatty acid transport (GO:2000192)2.64458566
76antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.64369042
77insulin-like growth factor receptor signaling pathway (GO:0048009)2.62500110
78COPI coating of Golgi vesicle (GO:0048205)2.61639251
79Golgi transport vesicle coating (GO:0048200)2.61639251
80regulation of spindle organization (GO:0090224)2.60175814
81interkinetic nuclear migration (GO:0022027)2.59666687
82sequestering of extracellular ligand from receptor (GO:0035581)2.58971292
83chondrocyte proliferation (GO:0035988)2.58739708
84sister chromatid segregation (GO:0000819)2.57056728
85regulation of transforming growth factor beta2 production (GO:0032909)2.55456406
86positive regulation of chromosome segregation (GO:0051984)2.54917461
87Golgi to endosome transport (GO:0006895)2.54544960
88L-alpha-amino acid transmembrane transport (GO:1902475)2.54436366
89regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.54008962
90wound healing, spreading of epidermal cells (GO:0035313)2.53693923
91vesicle coating (GO:0006901)2.52912442
92positive regulation of receptor recycling (GO:0001921)2.52489996
93spindle assembly involved in mitosis (GO:0090307)2.51680706
94detection of molecule of bacterial origin (GO:0032490)2.51623167
95negative regulation of fibroblast apoptotic process (GO:2000270)2.50557800
96cortical cytoskeleton organization (GO:0030865)2.49742525
97mammary gland epithelial cell proliferation (GO:0033598)2.48252854
98embryonic process involved in female pregnancy (GO:0060136)2.47502218
99regulation of DNA endoreduplication (GO:0032875)2.46679102
100regulation of integrin activation (GO:0033623)2.45318513
101monoubiquitinated protein deubiquitination (GO:0035520)2.44736054
102histone H3-K36 demethylation (GO:0070544)2.43932119
103peptidyl-threonine modification (GO:0018210)2.43345737
104regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.43169041
105desmosome organization (GO:0002934)2.42650638
106dosage compensation (GO:0007549)2.42294180
107regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.42146658
108response to UV-C (GO:0010225)2.41762393
109positive regulation of blood vessel endothelial cell migration (GO:0043536)2.40784214
110histone H3-K9 demethylation (GO:0033169)2.40572749
111trophectodermal cell differentiation (GO:0001829)2.40523537
112nuclear envelope organization (GO:0006998)2.40310580
113oocyte development (GO:0048599)2.39583512
114positive regulation of protein import into nucleus, translocation (GO:0033160)2.35805252
115blood vessel maturation (GO:0001955)2.34536045
116mesenchymal-epithelial cell signaling (GO:0060638)2.33963769
117DNA unwinding involved in DNA replication (GO:0006268)2.33960674
118positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.33382525
119cell-substrate junction assembly (GO:0007044)2.33249640
120keratan sulfate catabolic process (GO:0042340)2.33172065
121cellular response to growth hormone stimulus (GO:0071378)2.33062898
122glomerular visceral epithelial cell development (GO:0072015)2.32613940
123collagen metabolic process (GO:0032963)2.31539844
124regulation of steroid hormone biosynthetic process (GO:0090030)2.30602960
125negative regulation of histone modification (GO:0031057)2.30499852
126histone mRNA catabolic process (GO:0071044)2.30439058
127protein targeting to vacuole (GO:0006623)2.30278442
128protein targeting to lysosome (GO:0006622)2.30278442
129establishment of protein localization to vacuole (GO:0072666)2.30278442
130regulation of anoikis (GO:2000209)2.29724601
131adherens junction assembly (GO:0034333)2.29615690
132cellular response to vitamin (GO:0071295)2.29442466
133negative regulation of chromatin modification (GO:1903309)2.29238635
134embryonic placenta development (GO:0001892)2.29094578
135regulation of early endosome to late endosome transport (GO:2000641)2.29045369
136positive regulation of p38MAPK cascade (GO:1900745)2.28919321
137peptidyl-threonine phosphorylation (GO:0018107)2.28819737
138positive regulation of fibroblast migration (GO:0010763)2.28394933
139gene silencing by RNA (GO:0031047)2.27107421
140smooth muscle tissue development (GO:0048745)2.26535382
141histone-serine phosphorylation (GO:0035404)2.26144250
142membrane protein ectodomain proteolysis (GO:0006509)2.25928887
143negative regulation of translation, ncRNA-mediated (GO:0040033)2.25887733
144regulation of translation, ncRNA-mediated (GO:0045974)2.25887733
145negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.25887733
146paraxial mesoderm development (GO:0048339)2.25815918
147vascular endothelial growth factor signaling pathway (GO:0038084)2.25815628
148cytoskeleton-dependent cytokinesis (GO:0061640)2.25778369
149import into cell (GO:0098657)2.25637930
150microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.25308819
151mesodermal cell differentiation (GO:0048333)2.24871286
152positive regulation of hormone biosynthetic process (GO:0046886)2.24410561
153definitive hemopoiesis (GO:0060216)2.23874532
154focal adhesion assembly (GO:0048041)2.23563345
155cell-substrate adherens junction assembly (GO:0007045)2.23563345
156stress fiber assembly (GO:0043149)2.22523109
157basement membrane organization (GO:0071711)2.22235309
158plasma membrane repair (GO:0001778)2.21472830
159barbed-end actin filament capping (GO:0051016)2.21465088
160interleukin-6-mediated signaling pathway (GO:0070102)2.21209392
161regulation of interferon-beta biosynthetic process (GO:0045357)2.20971425
162mRNA transcription (GO:0009299)2.20833818
163anterior/posterior axis specification, embryo (GO:0008595)2.20819972
164substrate adhesion-dependent cell spreading (GO:0034446)2.20744334
165viral entry into host cell (GO:0046718)2.20489917
166regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.20151489
167collagen catabolic process (GO:0030574)2.19928998
168negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.19550837
169negative regulation of cell killing (GO:0031342)2.19550837
170endodermal cell differentiation (GO:0035987)2.19460229
171dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.19453054
172histone lysine demethylation (GO:0070076)2.18746774
173positive regulation of interferon-alpha production (GO:0032727)2.18577439
174cytoskeletal anchoring at plasma membrane (GO:0007016)2.18568583
175SMAD protein complex assembly (GO:0007183)2.18428143
176protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.17606183
177protein localization to cell surface (GO:0034394)2.16920079
178germ cell migration (GO:0008354)2.16070753
179regulation of protein import into nucleus, translocation (GO:0033158)2.15857218

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.61393169
2EGR1_19374776_ChIP-ChIP_THP-1_Human4.62057024
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse4.48488701
4FOXM1_23109430_ChIP-Seq_U2OS_Human4.18724490
5SMAD_19615063_ChIP-ChIP_OVARY_Human3.97675240
6SALL1_21062744_ChIP-ChIP_HESCs_Human3.35007940
7STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.73669464
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.61338506
9* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.58194118
10ZNF217_24962896_ChIP-Seq_MCF-7_Human2.51438708
11CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.48672840
12WT1_19549856_ChIP-ChIP_CCG9911_Human2.43485156
13MYC_22102868_ChIP-Seq_BL_Human2.29769237
14TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.23191573
15ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.22208237
16CDX2_19796622_ChIP-Seq_MESCs_Mouse2.16608307
17TP63_17297297_ChIP-ChIP_HaCaT_Human2.13808495
18FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.13560796
19IRF8_22096565_ChIP-ChIP_GC-B_Human2.09589338
20TRIM28_21343339_ChIP-Seq_HEK293_Human1.97900075
21STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.97569444
22E2F4_17652178_ChIP-ChIP_JURKAT_Human1.94554190
23ESR1_20079471_ChIP-ChIP_T-47D_Human1.92533469
24SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.89995642
25CJUN_26792858_Chip-Seq_BT549_Human1.89446722
26AR_21909140_ChIP-Seq_LNCAP_Human1.82702314
27GATA2_21666600_ChIP-Seq_HMVEC_Human1.80391771
28EP300_21415370_ChIP-Seq_HL-1_Mouse1.79257191
29ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.75145788
30NRF2_20460467_ChIP-Seq_MEFs_Mouse1.73241593
31NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.73241593
32NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.72674798
33KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.72565563
34CLOCK_20551151_ChIP-Seq_293T_Human1.70037740
35AHR_22903824_ChIP-Seq_MCF-7_Human1.69140742
36TCF7_22412390_ChIP-Seq_EML_Mouse1.67046368
37TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.66808764
38E2F1_21310950_ChIP-Seq_MCF-7_Human1.64767672
39STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.61205942
40FOXO3_23340844_ChIP-Seq_DLD1_Human1.61052851
41MYB_21317192_ChIP-Seq_ERMYB_Mouse1.60112393
42SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.56473845
43* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.56034129
44FOXM1_26456572_ChIP-Seq_MCF-7_Human1.54068103
45* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.53858334
46CTNNB1_20460455_ChIP-Seq_HCT116_Human1.52715835
47KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.52471148
48Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.51690166
49* TFEB_21752829_ChIP-Seq_HELA_Human1.50728438
50ESR1_15608294_ChIP-ChIP_MCF-7_Human1.47375604
51AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.45668550
52IRF8_27001747_Chip-Seq_BMDM_Mouse1.45280916
53ARNT_22903824_ChIP-Seq_MCF-7_Human1.44282260
54BRD4_27068464_Chip-Seq_AML-cells_Mouse1.44007602
55IRF8_21731497_ChIP-ChIP_J774_Mouse1.43749145
56BRD4_25478319_ChIP-Seq_HGPS_Human1.41294896
57KDM2B_26808549_Chip-Seq_DND41_Human1.41088699
58HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.41060023
59GATA1_22025678_ChIP-Seq_K562_Human1.38137731
60SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.37952017
61P300_27058665_Chip-Seq_ZR-75-30cells_Human1.37672312
62GATA6_25053715_ChIP-Seq_YYC3_Human1.36692885
63KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.36362254
64KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.35653039
65SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.35637056
66BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.34006129
67RBPJ_22232070_ChIP-Seq_NCS_Mouse1.33971192
68DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.33640933
69FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.32668925
70IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.31418063
71VDR_24787735_ChIP-Seq_THP-1_Human1.31002954
72PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.29996252
73SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.29286155
74FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.28614338
75RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.27524834
76* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.27408679
77SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.27316540
78SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.27316540
79ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.26561762
80HIF1A_21447827_ChIP-Seq_MCF-7_Human1.25795730
81TCF4_18268006_ChIP-ChIP_LS174T_Human1.24882918
82TP63_23658742_ChIP-Seq_EP156T_Human1.24215302
83FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.23331101
84PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.23198766
85KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.23065779
86KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.23065779
87KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.23065779
88STAT3_1855785_ChIP-Seq_MESCs_Mouse1.22582783
89ATF3_27146783_Chip-Seq_COLON_Human1.20893778
90TBX20_22328084_ChIP-Seq_HEART_Mouse1.20202933
91TBX20_22080862_ChIP-Seq_HEART_Mouse1.20202933
92TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.18571025
93POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.16705483
94CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.16553415
95SALL4_18804426_ChIP-ChIP_XEN_Mouse1.16548355
96MYB_26560356_Chip-Seq_TH1_Human1.16237902
97VDR_21846776_ChIP-Seq_THP-1_Human1.15638543
98ZFP281_27345836_Chip-Seq_ESCs_Mouse1.15615830
99SPI1_23127762_ChIP-Seq_K562_Human1.14490050
100NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.14367450
101PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.13493092
102RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.13296130
103MAF_26560356_Chip-Seq_TH1_Human1.12996571
104TP53_16413492_ChIP-PET_HCT116_Human1.12548918
105NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.11811953
106PPAR_26484153_Chip-Seq_NCI-H1993_Human1.11706520
107VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.11563912
108NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.10106837
109ELK3_25401928_ChIP-Seq_HUVEC_Human1.09387598
110KDM2B_26808549_Chip-Seq_SUP-B15_Human1.07199837
111MYB_26560356_Chip-Seq_TH2_Human1.06889889
112MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.06001881
113TP53_18474530_ChIP-ChIP_U2OS_Human1.05775154
114NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.05279370
115* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.05140739
116SOX2_27498859_Chip-Seq_STOMACH_Mouse1.04857672
117WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.04769442
118PIAS1_25552417_ChIP-Seq_VCAP_Human1.04504466
119OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02332760
120FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.02129575
121UTX_26944678_Chip-Seq_JUKART_Human1.00804821
122FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.00729579
123PKCTHETA_26484144_Chip-Seq_BREAST_Human0.99831442
124TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.97999288
125CHD1_26751641_Chip-Seq_LNCaP_Human0.97858776
126NCOR1_26117541_ChIP-Seq_K562_Human0.97557856
127RUNX_20019798_ChIP-Seq_JUKART_Human0.97467601
128PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97432659
129ESR1_21235772_ChIP-Seq_MCF-7_Human0.96878870
130ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.96764016
131SOX2_20726797_ChIP-Seq_SW620_Human0.96695936
132* POU3F2_20337985_ChIP-ChIP_501MEL_Human0.96363064
133PU_27001747_Chip-Seq_BMDM_Mouse0.95934615
134FOXA2_19822575_ChIP-Seq_HepG2_Human0.95830289
135PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.95420367
136YAP1_20516196_ChIP-Seq_MESCs_Mouse0.95332010
137TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.95053552
138JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92667729
139UBF1/2_26484160_Chip-Seq_HMECs_Human0.92383569
140TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.91719854
141SOX9_24532713_ChIP-Seq_HFSC_Mouse0.91608099
142NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.90970639
143KDM2B_26808549_Chip-Seq_JURKAT_Human0.90219830
144KLF4_18555785_ChIP-Seq_MESCs_Mouse0.88430196
145CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.87692019

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation4.42854303
2MP0003705_abnormal_hypodermis_morpholog4.14545685
3MP0010352_gastrointestinal_tract_polyps4.03828347
4MP0005076_abnormal_cell_differentiation2.99799217
5MP0010307_abnormal_tumor_latency2.86984395
6MP0010234_abnormal_vibrissa_follicle2.83448386
7MP0003300_gastrointestinal_ulcer2.76585923
8MP0008438_abnormal_cutaneous_collagen2.72500504
9MP0003566_abnormal_cell_adhesion2.56113786
10MP0003950_abnormal_plasma_membrane2.51338992
11MP0002877_abnormal_melanocyte_morpholog2.02140830
12MP0010368_abnormal_lymphatic_system2.01035855
13MP0002009_preneoplasia1.94233299
14MP0005503_abnormal_tendon_morphology1.94046789
15MP0005409_darkened_coat_color1.92814035
16MP0003191_abnormal_cellular_cholesterol1.78854298
17MP0003303_peritoneal_inflammation1.74433622
18MP0003091_abnormal_cell_migration1.74162007
19MP0005408_hypopigmentation1.74059368
20MP0004185_abnormal_adipocyte_glucose1.73168329
21MP0005023_abnormal_wound_healing1.68080750
22MP0000733_abnormal_muscle_development1.64958456
23MP0009278_abnormal_bone_marrow1.64783016
24MP0005623_abnormal_meninges_morphology1.58138734
25MP0003111_abnormal_nucleus_morphology1.54920336
26MP0005275_abnormal_skin_tensile1.53036778
27MP0004197_abnormal_fetal_growth/weight/1.52341360
28MP0002086_abnormal_extraembryonic_tissu1.50621311
29MP0003828_pulmonary_edema1.49767137
30MP0001730_embryonic_growth_arrest1.47663944
31MP0004264_abnormal_extraembryonic_tissu1.47480833
32MP0005451_abnormal_body_composition1.45769255
33MP0001915_intracranial_hemorrhage1.45205156
34MP0001849_ear_inflammation1.43112224
35MP0003941_abnormal_skin_development1.42319399
36MP0000015_abnormal_ear_pigmentation1.40647701
37MP0009780_abnormal_chondrocyte_physiolo1.37785893
38MP0002088_abnormal_embryonic_growth/wei1.37668558
39MP0003045_fibrosis1.37069247
40MP0003984_embryonic_growth_retardation1.36560896
41MP0001672_abnormal_embryogenesis/_devel1.36286165
42MP0005380_embryogenesis_phenotype1.36286165
43MP0010094_abnormal_chromosome_stability1.36107521
44MP0003172_abnormal_lysosome_physiology1.35285559
45MP0008057_abnormal_DNA_replication1.33602276
46MP0003077_abnormal_cell_cycle1.32999265
47MP0004808_abnormal_hematopoietic_stem1.31973923
48MP0005058_abnormal_lysosome_morphology1.31000162
49MP0002084_abnormal_developmental_patter1.30160687
50MP0004233_abnormal_muscle_weight1.29402098
51MP0000350_abnormal_cell_proliferation1.29202637
52MP0001958_emphysema1.27044684
53MP0006054_spinal_hemorrhage1.26691028
54MP0000371_diluted_coat_color1.26168464
55MP0003693_abnormal_embryo_hatching1.25188479
56MP0002396_abnormal_hematopoietic_system1.23364977
57MP0003123_paternal_imprinting1.18493647
58MP0004957_abnormal_blastocyst_morpholog1.17860203
59MP0004272_abnormal_basement_membrane1.16347268
60MP0001697_abnormal_embryo_size1.16157849
61MP0002166_altered_tumor_susceptibility1.15144215
62MP0003453_abnormal_keratinocyte_physiol1.14493745
63MP0005171_absent_coat_pigmentation1.13329194
64MP0004084_abnormal_cardiac_muscle1.13279078
65MP0004947_skin_inflammation1.12473147
66MP0008260_abnormal_autophagy1.09670394
67MP0005257_abnormal_intraocular_pressure1.04885444
68MP0000428_abnormal_craniofacial_morphol1.04403378
69MP0009384_cardiac_valve_regurgitation1.04060339
70MP0002085_abnormal_embryonic_tissue1.02715898
71MP0000013_abnormal_adipose_tissue1.01984923
72MP0005666_abnormal_adipose_tissue1.01210678
73MP0009703_decreased_birth_body1.00991292
74MP0010678_abnormal_skin_adnexa1.00625343
75MP0003448_altered_tumor_morphology0.98966611
76MP0003868_abnormal_feces_composition0.98939624
77MP0002168_other_aberrant_phenotype0.97574933
78MP0002998_abnormal_bone_remodeling0.97467314
79MP0004036_abnormal_muscle_relaxation0.96937500
80MP0002925_abnormal_cardiovascular_devel0.96053740
81MP0001879_abnormal_lymphatic_vessel0.95949936
82MP0003890_abnormal_embryonic-extraembry0.95187819
83MP0005621_abnormal_cell_physiology0.94580316
84MP0002896_abnormal_bone_mineralization0.94472899
85MP0000516_abnormal_urinary_system0.93387073
86MP0005367_renal/urinary_system_phenotyp0.93387073
87MP0002060_abnormal_skin_morphology0.93313624
88MP0009053_abnormal_anal_canal0.93038469
89MP0002080_prenatal_lethality0.92902822
90MP0005164_abnormal_response_to0.92715957
91MP0002092_abnormal_eye_morphology0.92153510
92MP0008961_abnormal_basal_metabolism0.91624485
93MP0003279_aneurysm0.90909657
94MP0003436_decreased_susceptibility_to0.90149877
95MP0002006_tumorigenesis0.89906400
96MP0003567_abnormal_fetal_cardiomyocyte0.89368518
97MP0003121_genomic_imprinting0.89212611
98MP0003183_abnormal_peptide_metabolism0.87865300
99MP0009672_abnormal_birth_weight0.87425570
100MP0005397_hematopoietic_system_phenotyp0.85940463
101MP0001545_abnormal_hematopoietic_system0.85940463
102MP0002697_abnormal_eye_size0.82576962
103MP0004883_abnormal_blood_vessel0.82488152
104MP0002108_abnormal_muscle_morphology0.82343816
105MP0001542_abnormal_bone_strength0.81723510
106MP0003115_abnormal_respiratory_system0.80586191
107MP0008007_abnormal_cellular_replicative0.79938821
108MP0001243_abnormal_dermal_layer0.79420835
109MP0000432_abnormal_head_morphology0.79345759
110MP0005375_adipose_tissue_phenotype0.78774669
111MP0000383_abnormal_hair_follicle0.78430012
112MP0001299_abnormal_eye_distance/0.78353015
113MP0000604_amyloidosis0.77607077
114MP0003283_abnormal_digestive_organ0.77583423
115MP0000751_myopathy0.77358096
116MP0002128_abnormal_blood_circulation0.76861617
117MP0002254_reproductive_system_inflammat0.75998796
118MP0003252_abnormal_bile_duct0.75676128
119MP0000858_altered_metastatic_potential0.75301781
120MP0000427_abnormal_hair_cycle0.74426181
121MP0001661_extended_life_span0.74342354
122MP0005197_abnormal_uvea_morphology0.74306280
123MP0010630_abnormal_cardiac_muscle0.74272243
124MP0001293_anophthalmia0.73771083
125MP0002796_impaired_skin_barrier0.73607065
126MP0001614_abnormal_blood_vessel0.73599256
127MP0002928_abnormal_bile_duct0.73241147
128MP0005384_cellular_phenotype0.72914608
129MP0000537_abnormal_urethra_morphology0.71907929
130MP0005174_abnormal_tail_pigmentation0.71207759
131MP0006138_congestive_heart_failure0.70641477
132MP0005360_urolithiasis0.68301904
133MP0002269_muscular_atrophy0.66965493
134MP0000266_abnormal_heart_morphology0.66854439
135MP0003935_abnormal_craniofacial_develop0.66609393
136MP0001216_abnormal_epidermal_layer0.66547340
137MP0004087_abnormal_muscle_fiber0.66513732
138MP0000490_abnormal_crypts_of0.66471591
139MP0004134_abnormal_chest_morphology0.66462504
140MP0000767_abnormal_smooth_muscle0.66134995
141MP0001835_abnormal_antigen_presentation0.66131331
142MP0000627_abnormal_mammary_gland0.65413107
143MP0000759_abnormal_skeletal_muscle0.65109714
144MP0000747_muscle_weakness0.64990768
145MP0001186_pigmentation_phenotype0.64768447
146MP0000003_abnormal_adipose_tissue0.64192812
147MP0002127_abnormal_cardiovascular_syste0.64181159
148MP0000685_abnormal_immune_system0.62634091
149MP0004381_abnormal_hair_follicle0.62269194
150MP0005075_abnormal_melanosome_morpholog0.61155284

Predicted human phenotypes

RankGene SetZ-score
1Vascular tortuosity (HP:0004948)3.60503377
2Arterial tortuosity (HP:0005116)3.58808025
3Cerebral aneurysm (HP:0004944)3.32810348
4Spondylolisthesis (HP:0003302)3.17433689
5Subacute progressive viral hepatitis (HP:0006572)2.97382662
6Shallow orbits (HP:0000586)2.83753133
7Overgrowth (HP:0001548)2.82850632
8Wormian bones (HP:0002645)2.80378214
9Papillary thyroid carcinoma (HP:0002895)2.79927032
10Abnormality of the fingertips (HP:0001211)2.79086547
11Macroorchidism (HP:0000053)2.77246338
12Volvulus (HP:0002580)2.69495179
13Protrusio acetabuli (HP:0003179)2.66528006
14Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.60450359
15Cervical subluxation (HP:0003308)2.55351800
16Urethral obstruction (HP:0000796)2.51440445
17Ankle contracture (HP:0006466)2.49496745
18Abnormality of the astrocytes (HP:0100707)2.49114410
19Astrocytoma (HP:0009592)2.49114410
20Mitral stenosis (HP:0001718)2.48910432
21Hematochezia (HP:0002573)2.48733609
22Soft skin (HP:0000977)2.44828580
23Ependymoma (HP:0002888)2.43906240
24Mitral valve prolapse (HP:0001634)2.41294861
25Spinal rigidity (HP:0003306)2.40430313
26Delayed closure of the anterior fontanelle (HP:0001476)2.31846448
27Ulnar bowing (HP:0003031)2.30781515
28Peritonitis (HP:0002586)2.28110239
29Aortic aneurysm (HP:0004942)2.27524202
30Asymmetry of the thorax (HP:0001555)2.27001539
31Persistence of primary teeth (HP:0006335)2.26635563
32Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.25904466
33Vertebral compression fractures (HP:0002953)2.24887813
34Heterotopia (HP:0002282)2.24500113
35Metaphyseal cupping (HP:0003021)2.24025391
36Genu recurvatum (HP:0002816)2.23639504
37Aneurysm (HP:0002617)2.23487517
38Absent frontal sinuses (HP:0002688)2.23003521
39Biliary tract neoplasm (HP:0100574)2.21395192
40Hand muscle atrophy (HP:0009130)2.20198257
41Osteolytic defects of the hand bones (HP:0009699)2.18268270
42Osteolytic defects of the phalanges of the hand (HP:0009771)2.18268270
43Fragile skin (HP:0001030)2.18161746
44Vertebral arch anomaly (HP:0008438)2.18089503
45Short 4th metacarpal (HP:0010044)2.17897375
46Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.17897375
47Malignant gastrointestinal tract tumors (HP:0006749)2.15460873
48Gastrointestinal carcinoma (HP:0002672)2.15460873
49Dilatation of the ascending aorta (HP:0005111)2.13366316
50Long eyelashes (HP:0000527)2.10784723
51Follicular hyperkeratosis (HP:0007502)2.09741890
52Type 1 muscle fiber predominance (HP:0003803)2.08653347
53Upper limb amyotrophy (HP:0009129)2.06797949
54Distal upper limb amyotrophy (HP:0007149)2.06797949
55Termporal pattern (HP:0011008)2.06301370
56Insidious onset (HP:0003587)2.06301370
57Deviation of the thumb (HP:0009603)2.05677485
58Spinal cord lesions (HP:0100561)2.05407886
59Syringomyelia (HP:0003396)2.05407886
60Joint laxity (HP:0001388)2.01629335
61Long toe (HP:0010511)2.01240563
62Increased density of long bones (HP:0006392)2.00174165
63Dislocated radial head (HP:0003083)1.99981985
64Blue sclerae (HP:0000592)1.99774163
65High pitched voice (HP:0001620)1.99627162
66Autoimmune thrombocytopenia (HP:0001973)1.98952070
67Disinhibition (HP:0000734)1.98660978
68Premature rupture of membranes (HP:0001788)1.97372631
69Narrow palate (HP:0000189)1.94435435
70Bowel diverticulosis (HP:0005222)1.94295598
71Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.93810227
72Thoracolumbar scoliosis (HP:0002944)1.92240101
73Short nail (HP:0001799)1.91446401
74Skull defect (HP:0001362)1.91275085
75Abnormality of the right ventricle (HP:0001707)1.90795275
76Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.89538818
77Prominent nose (HP:0000448)1.88911954
78Broad thumb (HP:0011304)1.87656390
79Elbow flexion contracture (HP:0002987)1.87180261
80Periodontitis (HP:0000704)1.87176684
81Deep philtrum (HP:0002002)1.86982658
82Abnormality of dentin (HP:0010299)1.84770111
83Abnormality of the frontal sinuses (HP:0002687)1.84111420
84Neonatal short-limb short stature (HP:0008921)1.82994291
85Flat acetabular roof (HP:0003180)1.82900353
86Gingivitis (HP:0000230)1.82668287
87Resting tremor (HP:0002322)1.82520612
88Thyroid carcinoma (HP:0002890)1.82280810
89Proximal placement of thumb (HP:0009623)1.81389819
90Enlarged penis (HP:0000040)1.80652356
91Sandal gap (HP:0001852)1.80516601
92Thin bony cortex (HP:0002753)1.80026327
93Low anterior hairline (HP:0000294)1.78910564
94Increased variability in muscle fiber diameter (HP:0003557)1.78067359
95Glioma (HP:0009733)1.77361804
96Spinal muscular atrophy (HP:0007269)1.76926455
97Radial bowing (HP:0002986)1.76755806
98Agnosia (HP:0010524)1.76721554
99Truncal obesity (HP:0001956)1.76248534
100Hypoplasia of the iris (HP:0007676)1.76123183
101Lymphangioma (HP:0100764)1.75934208
102Cardiovascular calcification (HP:0011915)1.75798080
103Increased connective tissue (HP:0009025)1.75780256
104Hyperacusis (HP:0010780)1.75459403
105Abnormality of the acetabulum (HP:0003170)1.74958401
106Spastic diplegia (HP:0001264)1.74618526
107Striae distensae (HP:0001065)1.74182162
108Neoplasm of the oral cavity (HP:0100649)1.74035614
109Thickened calvaria (HP:0002684)1.73986001
110Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.73968491
111Transitional cell carcinoma of the bladder (HP:0006740)1.73615215
112Abnormality of the radial head (HP:0003995)1.73251619
113Aortic regurgitation (HP:0001659)1.73030264
114Ankyloglossia (HP:0010296)1.72452204
115Cutaneous melanoma (HP:0012056)1.71623005
116Abnormality of oral frenula (HP:0000190)1.70130000
117Disproportionate tall stature (HP:0001519)1.70003543
118Relative macrocephaly (HP:0004482)1.69631549
119Tibial bowing (HP:0002982)1.69581148
120Wrist flexion contracture (HP:0001239)1.68661127
121Short humerus (HP:0005792)1.68389567
122Knee flexion contracture (HP:0006380)1.66974558
123Delayed cranial suture closure (HP:0000270)1.66861015
124Bladder neoplasm (HP:0009725)1.65900879
125Bladder carcinoma (HP:0002862)1.65900879
126Wide anterior fontanel (HP:0000260)1.65707902
127Hyperextensible skin (HP:0000974)1.65284541
128Mitral regurgitation (HP:0001653)1.65034799
129Myocardial infarction (HP:0001658)1.64508711
130Broad ribs (HP:0000885)1.64456038
131Fibrous tissue neoplasm (HP:0012316)1.64280746
132Abnormality of skeletal muscle fiber size (HP:0012084)1.63823516
133Abnormality of the peritoneum (HP:0002585)1.63635920
134Acute myeloid leukemia (HP:0004808)1.63301681
135Cubitus valgus (HP:0002967)1.62770194
136Selective tooth agenesis (HP:0001592)1.62654412
137Craniofacial hyperostosis (HP:0004493)1.62488724
138Leiomyosarcoma (HP:0100243)1.62333166
139Uterine leiomyosarcoma (HP:0002891)1.62333166
140Camptodactyly of toe (HP:0001836)1.61722570
141Cortical dysplasia (HP:0002539)1.61322828
142Fibroma (HP:0010614)1.61146164
143Uterine neoplasm (HP:0010784)1.61041235
144Coarse hair (HP:0002208)1.61026403
145Increased nuchal translucency (HP:0010880)1.60290071
146Aortic dissection (HP:0002647)1.59900937
147Abnormality of the vasculature of the conjunctiva (HP:0008054)1.59113528
148Rectal prolapse (HP:0002035)1.58772905
149Ovoid vertebral bodies (HP:0003300)1.58479881
150Right ventricular cardiomyopathy (HP:0011663)1.58453650
151Viral hepatitis (HP:0006562)1.57746208
152Abnormality of glycolipid metabolism (HP:0010969)1.56562303
153Abnormality of liposaccharide metabolism (HP:0010968)1.56562303
154Abnormality of glycosphingolipid metabolism (HP:0004343)1.56562303
155Conjunctival telangiectasia (HP:0000524)1.56228020
156Frequent falls (HP:0002359)1.56212228
157Abnormality of the 4th metacarpal (HP:0010012)1.56201415
158Hypopigmentation of the fundus (HP:0007894)1.55747088
159Rhabdomyosarcoma (HP:0002859)1.54894129
160Cranial hyperostosis (HP:0004437)1.54613704
161Broad metatarsal (HP:0001783)1.53836604
162Bladder diverticulum (HP:0000015)1.51792928
163Eczematoid dermatitis (HP:0000976)1.50514897
164Atrophic scars (HP:0001075)1.50213963
165Micronodular cirrhosis (HP:0001413)1.49473626
166Large earlobe (HP:0009748)1.49029244
167Elfin facies (HP:0004428)1.48558622
168Broad phalanges of the hand (HP:0009768)1.46393607
169Global brain atrophy (HP:0002283)1.46268531

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.68090706
2LATS13.08112741
3PKN22.86524702
4TTN2.41739045
5TRIB32.35309738
6SCYL22.34235132
7CAMK1D2.26732147
8BRD42.22321018
9PDGFRA2.12041599
10EEF2K2.10818269
11CDC72.10533396
12MAP3K101.96094091
13AKT31.92637184
14RIPK11.92229339
15FRK1.88560846
16STK31.81872072
17PRPF4B1.81391289
18BMPR1B1.80062844
19MST1R1.79098309
20CAMK1G1.78047493
21PTK61.77697694
22PIK3CG1.73397970
23NEK21.69359140
24FGFR31.52465348
25STK241.52141042
26CDK61.48998288
27MTOR1.43620913
28STK101.42693361
29BMX1.38215401
30ALK1.37400184
31MYLK1.32770082
32TTK1.29703778
33DDR21.29487498
34STK38L1.28789345
35PDGFRB1.26631707
36MAP3K131.22370111
37MAP2K31.21414872
38JAK11.18587586
39ERN11.17651559
40FGFR41.15363837
41MET1.13080736
42EIF2AK31.11177598
43FLT31.07582781
44JAK31.04714466
45NUAK11.02893743
46EPHA31.01943770
47NEK10.99977074
48IRAK10.99859271
49TYK20.98702340
50SIK10.98296502
51YES10.97224905
52PAK40.96094442
53MAP3K20.95765014
54PTK20.95040963
55LRRK20.94240704
56MOS0.93273919
57MAP3K80.90451186
58RET0.89240442
59ERBB40.88980666
60CDK40.88428593
61KSR10.86417839
62CDC42BPA0.86301854
63EPHA20.83342223
64STK380.82009687
65MAP3K30.79838825
66PAK20.79546571
67ATR0.79094452
68CHEK10.79005955
69FGFR20.78703595
70RPS6KA40.78427460
71EPHB10.77775158
72NEK60.76996583
73FGFR10.76968515
74ATM0.75080896
75TGFBR10.73917865
76TRPM70.73814249
77RPS6KB20.73093086
78NTRK10.72347587
79KSR20.71660558
80CDK90.71486464
81LATS20.71323662
82WNK10.69860524
83CSF1R0.69710956
84MELK0.69619370
85DMPK0.68641266
86STK40.66832139
87MAP3K60.65633326
88TAOK30.65611633
89CHUK0.65387871
90ERBB30.65235449
91HCK0.63955034
92PASK0.63625446
93PRKD20.63317215
94ACVR1B0.62899885
95SGK30.62771677
96ZAP700.62655768
97NLK0.62124578
98PBK0.61530694
99BLK0.61229962
100EGFR0.60396586
101BMPR20.59299154
102TEC0.58103906
103NEK90.57894851
104CSK0.56800623
105RPS6KB10.56771602
106MAP3K140.55833773
107SGK20.55368433
108MARK30.55118162
109PTK2B0.54846868
110SIK20.54562593
111CDK20.54445867
112MAPK110.53893513
113JAK20.52622813
114PIM10.52455501
115MAP3K10.52342691
116ICK0.51645415
117CSNK1D0.51150172
118WNK30.50238267
119MAP3K70.49632482
120MARK20.49380328
121PRKAA20.48616080
122RAF10.46870015
123MAP3K90.46157696
124IRAK30.45772194
125BRSK20.44807056
126MAPK70.44513554
127SMG10.43961634
128FER0.43886767
129GSK3A0.43457577
130TGFBR20.42964445
131AURKB0.42815025
132TYRO30.41749312
133PRKDC0.41701856
134CDK70.41390331
135FGR0.41167243
136ITK0.41000217
137INSR0.40405702
138MAPK10.38012589
139TIE10.37517682
140MAPK100.37254534
141PLK10.36385541
142MAPK140.36290970
143PNCK0.36242195

Predicted pathways (KEGG)

RankGene SetZ-score
1Lysine degradation_Homo sapiens_hsa003101.85751450
2Adherens junction_Homo sapiens_hsa045201.82234320
3MicroRNAs in cancer_Homo sapiens_hsa052061.71071701
4Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.69917583
5Small cell lung cancer_Homo sapiens_hsa052221.66728952
6Chronic myeloid leukemia_Homo sapiens_hsa052201.66034681
7mTOR signaling pathway_Homo sapiens_hsa041501.66017284
8One carbon pool by folate_Homo sapiens_hsa006701.65721755
9Other glycan degradation_Homo sapiens_hsa005111.64789076
10Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.52143468
11Proteoglycans in cancer_Homo sapiens_hsa052051.45904273
12Focal adhesion_Homo sapiens_hsa045101.41181164
13Pancreatic cancer_Homo sapiens_hsa052121.26102408
14Type II diabetes mellitus_Homo sapiens_hsa049301.25766371
15Antigen processing and presentation_Homo sapiens_hsa046121.22869906
16Osteoclast differentiation_Homo sapiens_hsa043801.21271379
17Nitrogen metabolism_Homo sapiens_hsa009101.20971237
18ECM-receptor interaction_Homo sapiens_hsa045121.18923025
19Endometrial cancer_Homo sapiens_hsa052131.18824754
20Central carbon metabolism in cancer_Homo sapiens_hsa052301.18591225
21Insulin resistance_Homo sapiens_hsa049311.18217832
22Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.16832089
23Toxoplasmosis_Homo sapiens_hsa051451.16774826
24Leukocyte transendothelial migration_Homo sapiens_hsa046701.16033401
25Viral myocarditis_Homo sapiens_hsa054161.15414193
26Viral carcinogenesis_Homo sapiens_hsa052031.15390653
27Dorso-ventral axis formation_Homo sapiens_hsa043201.13270708
28Leishmaniasis_Homo sapiens_hsa051401.12963430
29Amoebiasis_Homo sapiens_hsa051461.12117539
30AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.12066725
31Thyroid hormone signaling pathway_Homo sapiens_hsa049191.12023693
32Carbohydrate digestion and absorption_Homo sapiens_hsa049731.09498960
33Glioma_Homo sapiens_hsa052141.08841662
34Non-small cell lung cancer_Homo sapiens_hsa052231.08440231
35Selenocompound metabolism_Homo sapiens_hsa004501.07395378
36NF-kappa B signaling pathway_Homo sapiens_hsa040641.06835514
37Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.05582228
38Prostate cancer_Homo sapiens_hsa052151.04446733
39Malaria_Homo sapiens_hsa051441.04393439
40Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.03788658
41B cell receptor signaling pathway_Homo sapiens_hsa046621.03695583
42Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.00712901
43Cell cycle_Homo sapiens_hsa041101.00690469
44ErbB signaling pathway_Homo sapiens_hsa040120.99484142
45Colorectal cancer_Homo sapiens_hsa052100.99008195
46Dilated cardiomyopathy_Homo sapiens_hsa054140.98686787
47Apoptosis_Homo sapiens_hsa042100.97583069
48Bladder cancer_Homo sapiens_hsa052190.96724077
49Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.95331997
50p53 signaling pathway_Homo sapiens_hsa041150.95188728
51TNF signaling pathway_Homo sapiens_hsa046680.94540904
52Neurotrophin signaling pathway_Homo sapiens_hsa047220.94532472
53NOD-like receptor signaling pathway_Homo sapiens_hsa046210.93330554
54Hepatitis B_Homo sapiens_hsa051610.92867463
55Influenza A_Homo sapiens_hsa051640.92520998
56Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.91248669
57Glycosaminoglycan degradation_Homo sapiens_hsa005310.91103295
58Herpes simplex infection_Homo sapiens_hsa051680.90610241
59RNA transport_Homo sapiens_hsa030130.90416090
60Regulation of actin cytoskeleton_Homo sapiens_hsa048100.89764290
61Phospholipase D signaling pathway_Homo sapiens_hsa040720.89680795
62HIF-1 signaling pathway_Homo sapiens_hsa040660.89447685
63Sphingolipid signaling pathway_Homo sapiens_hsa040710.88341657
64PI3K-Akt signaling pathway_Homo sapiens_hsa041510.88183222
65Tuberculosis_Homo sapiens_hsa051520.87721373
66Toll-like receptor signaling pathway_Homo sapiens_hsa046200.86701210
67Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.86459193
68mRNA surveillance pathway_Homo sapiens_hsa030150.85760647
69FoxO signaling pathway_Homo sapiens_hsa040680.85753248
70HTLV-I infection_Homo sapiens_hsa051660.84857192
71Transcriptional misregulation in cancer_Homo sapiens_hsa052020.84196847
72Acute myeloid leukemia_Homo sapiens_hsa052210.84155049
73Legionellosis_Homo sapiens_hsa051340.83839356
74TGF-beta signaling pathway_Homo sapiens_hsa043500.82826850
75Renal cell carcinoma_Homo sapiens_hsa052110.82482938
76GnRH signaling pathway_Homo sapiens_hsa049120.80277694
77VEGF signaling pathway_Homo sapiens_hsa043700.80177329
78Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.79663382
79Renin-angiotensin system_Homo sapiens_hsa046140.79479708
80Choline metabolism in cancer_Homo sapiens_hsa052310.78540197
81Measles_Homo sapiens_hsa051620.77481446
82Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.77469872
83Hippo signaling pathway_Homo sapiens_hsa043900.76279675
84Thyroid cancer_Homo sapiens_hsa052160.76064346
85T cell receptor signaling pathway_Homo sapiens_hsa046600.74788326
86Inositol phosphate metabolism_Homo sapiens_hsa005620.73820278
87Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.72948475
88Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.72563310
89Prolactin signaling pathway_Homo sapiens_hsa049170.72298767
90Lysosome_Homo sapiens_hsa041420.72261643
91Platelet activation_Homo sapiens_hsa046110.72044968
92Notch signaling pathway_Homo sapiens_hsa043300.71548058
93Shigellosis_Homo sapiens_hsa051310.70010365
94Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.69139020
95Phosphatidylinositol signaling system_Homo sapiens_hsa040700.68992690
96Melanoma_Homo sapiens_hsa052180.68802215
97Insulin signaling pathway_Homo sapiens_hsa049100.67835237
98Endocytosis_Homo sapiens_hsa041440.67567373
99Protein digestion and absorption_Homo sapiens_hsa049740.67411316
100Rap1 signaling pathway_Homo sapiens_hsa040150.66830056
101Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.66634566
102Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.66275178
103cGMP-PKG signaling pathway_Homo sapiens_hsa040220.66005042
104Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.65576217
105Sphingolipid metabolism_Homo sapiens_hsa006000.65565344
106Pathways in cancer_Homo sapiens_hsa052000.64954918
107Staphylococcus aureus infection_Homo sapiens_hsa051500.64662792
108Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.64243064
109Phagosome_Homo sapiens_hsa041450.63332080
110Longevity regulating pathway - mammal_Homo sapiens_hsa042110.62293855
111AMPK signaling pathway_Homo sapiens_hsa041520.62170394
112Gap junction_Homo sapiens_hsa045400.61128542
113Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.61059838
114Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.60188331
115Adipocytokine signaling pathway_Homo sapiens_hsa049200.59755806
116Hepatitis C_Homo sapiens_hsa051600.59738277
117Estrogen signaling pathway_Homo sapiens_hsa049150.58224072
118Jak-STAT signaling pathway_Homo sapiens_hsa046300.57754847
119Tight junction_Homo sapiens_hsa045300.57423855
120Long-term potentiation_Homo sapiens_hsa047200.56985836
121Salmonella infection_Homo sapiens_hsa051320.56844051
122Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.56615487
123Chemokine signaling pathway_Homo sapiens_hsa040620.56250786
124RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.54876741
125Complement and coagulation cascades_Homo sapiens_hsa046100.52785660

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