DNAJC14

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to microtubule (GO:0035372)6.09012318
2Golgi transport vesicle coating (GO:0048200)5.70796544
3COPI coating of Golgi vesicle (GO:0048205)5.70796544
4protein localization to kinetochore (GO:0034501)5.45518142
5protein localization to chromosome, centromeric region (GO:0071459)5.07607136
6antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.43354049
7antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.43354049
8regulation of histone H3-K27 methylation (GO:0061085)4.30370197
9histone H3-K36 demethylation (GO:0070544)4.28994351
10spliceosomal tri-snRNP complex assembly (GO:0000244)4.00796183
11antigen processing and presentation of endogenous antigen (GO:0019883)3.97033026
12low-density lipoprotein particle clearance (GO:0034383)3.74251432
13chaperone mediated protein folding requiring cofactor (GO:0051085)3.67719509
14iron ion import (GO:0097286)3.63453178
15growth hormone receptor signaling pathway (GO:0060396)3.60726660
16positive regulation of keratinocyte differentiation (GO:0045618)3.60087868
17microtubule cytoskeleton organization involved in mitosis (GO:1902850)3.60039216
18retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.57035177
19activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.53266941
20positive regulation of histone deacetylation (GO:0031065)3.48480430
21regulation of fatty acid beta-oxidation (GO:0031998)3.47118715
22nuclear pore complex assembly (GO:0051292)3.39998215
23maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.39775692
24positive regulation of nuclease activity (GO:0032075)3.38272866
25regulation of cholesterol homeostasis (GO:2000188)3.37891976
26apoptotic cell clearance (GO:0043277)3.33842607
27lysine catabolic process (GO:0006554)3.31667771
28lysine metabolic process (GO:0006553)3.31667771
29regulation of translational fidelity (GO:0006450)3.31281198
30peptidyl-threonine dephosphorylation (GO:0035970)3.30335228
31alpha-linolenic acid metabolic process (GO:0036109)3.28115639
32regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.28033860
33regulation of cholesterol storage (GO:0010885)3.24170641
34amyloid precursor protein catabolic process (GO:0042987)3.22599665
35snRNA metabolic process (GO:0016073)3.20898086
36attachment of spindle microtubules to kinetochore (GO:0008608)3.18531612
37positive regulation of fatty acid beta-oxidation (GO:0032000)3.17208728
38regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.16770953
39glucocorticoid receptor signaling pathway (GO:0042921)3.15069105
40protein retention in ER lumen (GO:0006621)3.14138728
41protein localization to endosome (GO:0036010)3.10279192
42cellular response to growth hormone stimulus (GO:0071378)3.08836475
43regulation of nuclease activity (GO:0032069)3.06225182
44endoplasmic reticulum unfolded protein response (GO:0030968)3.05994981
45norepinephrine metabolic process (GO:0042415)3.05703123
46proline biosynthetic process (GO:0006561)3.04634501
47nuclear pore organization (GO:0006999)3.02756237
48activation of Rac GTPase activity (GO:0032863)3.00851525
49valine metabolic process (GO:0006573)2.98421927
50tricarboxylic acid metabolic process (GO:0072350)2.97069798
51snRNA processing (GO:0016180)2.95237718
52sulfur amino acid catabolic process (GO:0000098)2.94889842
53corticosteroid receptor signaling pathway (GO:0031958)2.94345998
54cellular response to unfolded protein (GO:0034620)2.91495982
55regulation of type I interferon-mediated signaling pathway (GO:0060338)2.91153070
56mitochondrial fusion (GO:0008053)2.90128477
57COPII vesicle coating (GO:0048208)2.88225865
58cell adhesion mediated by integrin (GO:0033627)2.87293214
59vesicle coating (GO:0006901)2.86498375
60positive regulation of cell cycle checkpoint (GO:1901978)2.86234081
613-UTR-mediated mRNA stabilization (GO:0070935)2.86131348
62ER-nucleus signaling pathway (GO:0006984)2.85155862
63negative regulation of cell size (GO:0045792)2.84108591
64negative regulation of fibrinolysis (GO:0051918)2.83798399
65negative regulation of fatty acid transport (GO:2000192)2.83199012
66fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.83146546
67negative regulation of lipid transport (GO:0032369)2.81891594
684-hydroxyproline metabolic process (GO:0019471)2.81586222
69positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.80612523
70ear development (GO:0043583)2.79945696
71sexual reproduction (GO:0019953)2.78545182
72peptidyl-glutamic acid carboxylation (GO:0017187)2.76705082
73protein carboxylation (GO:0018214)2.76705082
74cellular response to topologically incorrect protein (GO:0035967)2.74868896
75positive regulation of Cdc42 GTPase activity (GO:0043089)2.74575366
76embryonic process involved in female pregnancy (GO:0060136)2.73744758
77membrane protein ectodomain proteolysis (GO:0006509)2.72205020
78pore complex assembly (GO:0046931)2.69579475
79hepatocyte apoptotic process (GO:0097284)2.67690677
80protein demethylation (GO:0006482)2.66629757
81protein dealkylation (GO:0008214)2.66629757
822-oxoglutarate metabolic process (GO:0006103)2.66297701
83positive regulation of p38MAPK cascade (GO:1900745)2.64315961
84regulation of gamma-delta T cell differentiation (GO:0045586)2.63924957
85DNA duplex unwinding (GO:0032508)2.63350612
86erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.63239353
87L-phenylalanine metabolic process (GO:0006558)2.63239353
88histone demethylation (GO:0016577)2.63206104
89positive regulation of gamma-delta T cell activation (GO:0046645)2.62493685
90intracellular estrogen receptor signaling pathway (GO:0030520)2.62430921
91epithelial cell differentiation involved in prostate gland development (GO:0060742)2.61462885
92urea cycle (GO:0000050)2.60850601
93urea metabolic process (GO:0019627)2.60850601
94complement activation, alternative pathway (GO:0006957)2.58723344
95peptidyl-arginine omega-N-methylation (GO:0035247)2.58473889
96protein-DNA complex disassembly (GO:0032986)2.56191715
97nucleosome disassembly (GO:0006337)2.56191715
98regulation of RNA export from nucleus (GO:0046831)2.54900724
99mRNA stabilization (GO:0048255)2.54012393
100RNA stabilization (GO:0043489)2.54012393
101zinc ion homeostasis (GO:0055069)2.53514630
102response to muramyl dipeptide (GO:0032495)2.52832144
103regulation of protein polyubiquitination (GO:1902914)2.52039204
104maternal placenta development (GO:0001893)2.51890371
105erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.50967507
106L-phenylalanine catabolic process (GO:0006559)2.50967507
107negative regulation of microtubule polymerization (GO:0031115)2.50829671
108establishment of apical/basal cell polarity (GO:0035089)2.50777309
109membrane protein intracellular domain proteolysis (GO:0031293)2.50072476
110cellular response to virus (GO:0098586)2.49826066
111positive regulation of endothelial cell apoptotic process (GO:2000353)2.48848538
112vascular endothelial growth factor signaling pathway (GO:0038084)2.48604551
113positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.48464947
114cellular zinc ion homeostasis (GO:0006882)2.47597161
115plasma lipoprotein particle clearance (GO:0034381)2.47585963
116macroautophagy (GO:0016236)2.47474312
117positive regulation of fatty acid oxidation (GO:0046321)2.47364100
118regulation of hippo signaling (GO:0035330)2.47089843
119DNA geometric change (GO:0032392)2.46063254
120regulation of fatty acid oxidation (GO:0046320)2.46041502
121branching involved in mammary gland duct morphogenesis (GO:0060444)2.45193998
122protein localization to microtubule cytoskeleton (GO:0072698)2.42963928
123morphogenesis of an endothelium (GO:0003159)2.42736185
124endothelial tube morphogenesis (GO:0061154)2.42736185
125heparin metabolic process (GO:0030202)2.42488532
126heparin biosynthetic process (GO:0030210)2.42488532
127JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.42109281
128positive regulation of epidermal cell differentiation (GO:0045606)2.42091931
129antigen processing and presentation via MHC class Ib (GO:0002475)2.41945858
130phospholipid homeostasis (GO:0055091)2.41681919
131pentose-phosphate shunt (GO:0006098)2.41466480
132triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.40937687
133histone lysine demethylation (GO:0070076)2.40214177
134regulation of defense response to virus by virus (GO:0050690)2.39039255
135nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.38636326
136interferon-gamma secretion (GO:0072643)2.37940238
137positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.37923916
138positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.37821174
139negative regulation of viral release from host cell (GO:1902187)2.37194951
140stress fiber assembly (GO:0043149)2.36102854
141mitotic cell cycle arrest (GO:0071850)2.35706606
142embryonic camera-type eye morphogenesis (GO:0048596)2.35555669
143diol metabolic process (GO:0034311)2.35493893
144embryonic eye morphogenesis (GO:0048048)2.35406135
145sphingomyelin metabolic process (GO:0006684)2.34929196
146mannose metabolic process (GO:0006013)2.34560419
147positive regulation of lipid catabolic process (GO:0050996)2.34493864
148positive regulation of glycogen biosynthetic process (GO:0045725)2.34415215
149positive regulation of protein deacetylation (GO:0090312)2.33783329
150fatty acid transmembrane transport (GO:1902001)2.33756957
151fatty acid homeostasis (GO:0055089)2.33579462
152regulation of nucleobase-containing compound transport (GO:0032239)2.33336131
153basement membrane organization (GO:0071711)2.32854285
154regulation of protein activation cascade (GO:2000257)2.32641120
155response to endoplasmic reticulum stress (GO:0034976)2.32097186
156cellular response to interleukin-4 (GO:0071353)2.31916908
157insulin-like growth factor receptor signaling pathway (GO:0048009)2.31323075
158Golgi organization (GO:0007030)2.31213849
159positive thymic T cell selection (GO:0045059)2.30878319
160regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.30421483
161kynurenine metabolic process (GO:0070189)2.30420331
162response to laminar fluid shear stress (GO:0034616)2.30255031
163negative regulation of histone methylation (GO:0031061)2.30174866
164regulation of gamma-delta T cell activation (GO:0046643)2.29713383
165regulation of complement activation (GO:0030449)2.29265491
166focal adhesion assembly (GO:0048041)2.28086580
167cell-substrate adherens junction assembly (GO:0007045)2.28086580
168semaphorin-plexin signaling pathway (GO:0071526)2.27759858
169cysteine metabolic process (GO:0006534)2.27695257
170regulation of glucose import in response to insulin stimulus (GO:2001273)2.27636656
171oxaloacetate metabolic process (GO:0006107)2.27529857
172protein localization to chromosome (GO:0034502)2.26838135
173endothelial cell morphogenesis (GO:0001886)2.25917132
174regulation of centriole replication (GO:0046599)2.25750877
175fatty acid beta-oxidation (GO:0006635)2.24323429
176negative regulation of cholesterol transport (GO:0032375)2.23891473
177negative regulation of sterol transport (GO:0032372)2.23891473
178lipoprotein metabolic process (GO:0042157)2.22853549
179negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.21487881
180nitrogen cycle metabolic process (GO:0071941)2.19589928
181positive regulation of triglyceride biosynthetic process (GO:0010867)2.18725313
182L-alpha-amino acid transmembrane transport (GO:1902475)2.18678569
183response to growth hormone (GO:0060416)2.18434979
184skin morphogenesis (GO:0043589)2.17802952
185peptidyl-lysine dimethylation (GO:0018027)2.17516046
186regulation of interleukin-12 biosynthetic process (GO:0045075)2.16977069
187fatty acid oxidation (GO:0019395)2.15939481

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.27469185
2NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.87575655
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.20181028
4RXR_22158963_ChIP-Seq_LIVER_Mouse3.18215384
5* PPARA_22158963_ChIP-Seq_LIVER_Mouse3.16264263
6E2F7_22180533_ChIP-Seq_HELA_Human2.95163505
7CLOCK_20551151_ChIP-Seq_293T_Human2.86210679
8LXR_22158963_ChIP-Seq_LIVER_Mouse2.68795515
9EGR1_19374776_ChIP-ChIP_THP-1_Human2.67499852
10MYC_22102868_ChIP-Seq_BL_Human2.51916387
11STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.51230906
12CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat2.33884121
13TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.26719987
14DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.24321357
15STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.14323057
16TP63_17297297_ChIP-ChIP_HaCaT_Human2.10492344
17RARG_19884340_ChIP-ChIP_MEFs_Mouse2.08087473
18IRF8_22096565_ChIP-ChIP_GC-B_Human2.07297520
19TCF7_22412390_ChIP-Seq_EML_Mouse1.85657587
20* ELK3_25401928_ChIP-Seq_HUVEC_Human1.81976787
21* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.77882965
22HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.75424543
23GATA1_22025678_ChIP-Seq_K562_Human1.74872896
24NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.74851663
25KDM2B_26808549_Chip-Seq_SUP-B15_Human1.74066919
26CIITA_25753668_ChIP-Seq_RAJI_Human1.70189179
27KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.70082106
28MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.67271511
29NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.67017947
30KDM2B_26808549_Chip-Seq_DND41_Human1.65657980
31FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.64877368
32FOXO3_23340844_ChIP-Seq_DLD1_Human1.64656522
33CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.64077250
34TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.63511443
35STAT6_21828071_ChIP-Seq_BEAS2B_Human1.62838239
36NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.62602411
37VDR_21846776_ChIP-Seq_THP-1_Human1.60573162
38KDM5A_27292631_Chip-Seq_BREAST_Human1.60167460
39E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.59223797
40KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.57735492
41NOTCH1_21737748_ChIP-Seq_TLL_Human1.57202777
42BRD4_27068464_Chip-Seq_AML-cells_Mouse1.54714572
43ZNF263_19887448_ChIP-Seq_K562_Human1.53635068
44RACK7_27058665_Chip-Seq_MCF-7_Human1.53467472
45TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.53238643
46* MAF_26560356_Chip-Seq_TH1_Human1.52658652
47LXR_22292898_ChIP-Seq_THP-1_Human1.52351222
48ESR1_15608294_ChIP-ChIP_MCF-7_Human1.51972647
49FOXM1_23109430_ChIP-Seq_U2OS_Human1.51666598
50ATF3_27146783_Chip-Seq_COLON_Human1.51664275
51ESR2_21235772_ChIP-Seq_MCF-7_Human1.51018785
52IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.50214458
53UTX_26944678_Chip-Seq_JUKART_Human1.49488932
54FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.49345601
55MYB_21317192_ChIP-Seq_ERMYB_Mouse1.47907420
56* XRN2_22483619_ChIP-Seq_HELA_Human1.47741299
57HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.47483580
58* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.46882805
59RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.46156910
60DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.45153660
61ESR1_20079471_ChIP-ChIP_T-47D_Human1.44260955
62FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.44049721
63ELF1_17652178_ChIP-ChIP_JURKAT_Human1.43745047
64ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.40941397
65TFEB_21752829_ChIP-Seq_HELA_Human1.40916325
66KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.39960457
67CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.39924019
68PKCTHETA_26484144_Chip-Seq_BREAST_Human1.39582669
69SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.39137266
70FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.38598567
71SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.37159930
72* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.36802269
73* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.36629348
74TP53_22127205_ChIP-Seq_IMR90_Human1.34148592
75* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.33873599
76MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.30208059
77* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.29625616
78BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.27422819
79RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.26648429
80ESR1_21235772_ChIP-Seq_MCF-7_Human1.25022572
81IRF8_27001747_Chip-Seq_BMDM_Mouse1.24229786
82MYB_26560356_Chip-Seq_TH2_Human1.21447693
83SPI1_23127762_ChIP-Seq_K562_Human1.21206026
84TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.20069199
85PPAR_26484153_Chip-Seq_NCI-H1993_Human1.19630394
86* P68_20966046_ChIP-Seq_HELA_Human1.18384971
87NELFA_20434984_ChIP-Seq_ESCs_Mouse1.17845885
88FOXA2_19822575_ChIP-Seq_HepG2_Human1.17542824
89* GATA6_25053715_ChIP-Seq_YYC3_Human1.17542327
90DCP1A_22483619_ChIP-Seq_HELA_Human1.17481810
91NCOR1_26117541_ChIP-Seq_K562_Human1.17259231
92UBF1/2_26484160_Chip-Seq_HMECs_Human1.16485675
93GATA1_19941826_ChIP-Seq_K562_Human1.16251671
94TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.15967698
95EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.15914758
96CTCF_27219007_Chip-Seq_ERYTHROID_Human1.15337327
97SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.14461911
98VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.14165063
99MAF_26560356_Chip-Seq_TH2_Human1.13542936
100TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.13269692
101TBX20_22328084_ChIP-Seq_HEART_Mouse1.12702463
102TBX20_22080862_ChIP-Seq_HEART_Mouse1.12702463
103KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.12426189
104FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.11848748
105BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.11470607
106CHD1_26751641_Chip-Seq_LNCaP_Human1.10927304
107* RUNX1_27514584_Chip-Seq_MCF-7_Human1.10905747
108CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.10800255
109STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.07766162
110MYB_26560356_Chip-Seq_TH1_Human1.07277009
111* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.07227780
112KDM2B_26808549_Chip-Seq_JURKAT_Human1.06730691
113KLF4_18555785_ChIP-Seq_MESCs_Mouse1.06536932
114ELF1_20517297_ChIP-Seq_JURKAT_Human1.06164768
115GATA2_21666600_ChIP-Seq_HMVEC_Human1.05791308
116NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.04861961
117FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.04608133
118SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human1.03709269
119EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.02875358
120VDR_24763502_ChIP-Seq_THP-1_Human1.01962361
121AR_21909140_ChIP-Seq_LNCAP_Human1.01227163
122SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.01134358
123IRF8_21731497_ChIP-ChIP_J774_Mouse1.01123798
124EGR1_23403033_ChIP-Seq_LIVER_Mouse1.00413420
125SMC4_20622854_ChIP-Seq_HELA_Human1.00249440
126ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.00237695
127RUNX_20019798_ChIP-Seq_JUKART_Human1.00148138
128PADI4_21655091_ChIP-ChIP_MCF-7_Human0.99690429
129HIF1A_21447827_ChIP-Seq_MCF-7_Human0.99335092
130NANOG_18555785_ChIP-Seq_MESCs_Mouse0.99212458
131GATA1_22383799_ChIP-Seq_G1ME_Mouse0.99205193
132ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.98920710
133* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.98355635
134TET1_21451524_ChIP-Seq_MESCs_Mouse0.98236763
135RUNX1_22412390_ChIP-Seq_EML_Mouse0.98231346
136MYCN_18555785_ChIP-Seq_MESCs_Mouse0.98214341
137GATA4_25053715_ChIP-Seq_YYC3_Human0.97540780
138GATA1_19941827_ChIP-Seq_MEL_Mouse0.96847267
139RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.96474009
140RARB_24833708_ChIP-Seq_LIVER_Mouse0.96295939
141KDM2B_26808549_Chip-Seq_K562_Human0.95785844
142STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.94612737
143GATA2_19941826_ChIP-Seq_K562_Human0.94184679
144THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.93949741
145GATA3_27048872_Chip-Seq_THYMUS_Human0.93114374
146SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.91470178
147SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.91470178
148Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.90717052
149ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.90441762
150CREB1_26743006_Chip-Seq_LNCaP_Human0.89621005
151HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.88175464

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog3.96919012
2MP0002009_preneoplasia3.17830204
3MP0002139_abnormal_hepatobiliary_system3.04820190
4MP0003300_gastrointestinal_ulcer3.02785318
5MP0010234_abnormal_vibrissa_follicle2.88850907
6MP0005360_urolithiasis2.84790788
7MP0005451_abnormal_body_composition2.71170053
8MP0008438_abnormal_cutaneous_collagen2.64637033
9MP0009840_abnormal_foam_cell2.58081626
10MP0005365_abnormal_bile_salt2.51683289
11MP0005409_darkened_coat_color2.43379610
12MP0001348_abnormal_lacrimal_gland2.30610945
13MP0010352_gastrointestinal_tract_polyps2.25970071
14MP0004381_abnormal_hair_follicle2.25004630
15MP0003329_amyloid_beta_deposits2.23681010
16MP0004233_abnormal_muscle_weight2.16317111
17MP0000569_abnormal_digit_pigmentation2.13949312
18MP0003252_abnormal_bile_duct2.13261604
19MP0003191_abnormal_cellular_cholesterol2.01042193
20MP0000537_abnormal_urethra_morphology2.00918809
21MP0002877_abnormal_melanocyte_morpholog2.00576746
22MP0000015_abnormal_ear_pigmentation1.95481712
23MP0005085_abnormal_gallbladder_physiolo1.90786671
24MP0003566_abnormal_cell_adhesion1.89943657
25MP0003303_peritoneal_inflammation1.88819780
26MP0005076_abnormal_cell_differentiation1.85488338
27MP0010329_abnormal_lipoprotein_level1.76407991
28MP0005058_abnormal_lysosome_morphology1.73238772
29MP0006054_spinal_hemorrhage1.71814445
30MP0004185_abnormal_adipocyte_glucose1.65102582
31MP0000013_abnormal_adipose_tissue1.56476275
32MP0000609_abnormal_liver_physiology1.54278090
33MP0004130_abnormal_muscle_cell1.52877348
34MP0000383_abnormal_hair_follicle1.52662912
35MP0002138_abnormal_hepatobiliary_system1.49633758
36MP0004947_skin_inflammation1.47705771
37MP0005275_abnormal_skin_tensile1.46942534
38MP0010678_abnormal_skin_adnexa1.43931900
39MP0005023_abnormal_wound_healing1.43788820
40MP0008961_abnormal_basal_metabolism1.40528327
41MP0000003_abnormal_adipose_tissue1.40199451
42MP0003111_abnormal_nucleus_morphology1.39196987
43MP0001666_abnormal_nutrient_absorption1.35490430
44MP0005501_abnormal_skin_physiology1.35365875
45MP0003693_abnormal_embryo_hatching1.34329667
46MP0002837_dystrophic_cardiac_calcinosis1.32078054
47MP0003045_fibrosis1.30407694
48MP0009643_abnormal_urine_homeostasis1.30391132
49MP0005248_abnormal_Harderian_gland1.29551611
50MP0008875_abnormal_xenobiotic_pharmacok1.29521328
51MP0003091_abnormal_cell_migration1.28899389
52MP0005171_absent_coat_pigmentation1.28454744
53MP0000377_abnormal_hair_follicle1.28319210
54MP0005666_abnormal_adipose_tissue1.25748278
55MP0003077_abnormal_cell_cycle1.25450622
56MP0005375_adipose_tissue_phenotype1.23329950
57MP0001243_abnormal_dermal_layer1.21450930
58MP0002909_abnormal_adrenal_gland1.20299917
59MP0002166_altered_tumor_susceptibility1.19505776
60MP0010307_abnormal_tumor_latency1.19494286
61MP0004264_abnormal_extraembryonic_tissu1.18018900
62MP0003959_abnormal_lean_body1.17003984
63MP0009278_abnormal_bone_marrow1.16851949
64MP0001216_abnormal_epidermal_layer1.16547720
65MP0001849_ear_inflammation1.16245732
66MP0001756_abnormal_urination1.15433433
67MP0001958_emphysema1.13311950
68MP0010368_abnormal_lymphatic_system1.11798819
69MP0003183_abnormal_peptide_metabolism1.10547967
70MP0005083_abnormal_biliary_tract1.09044308
71MP0000685_abnormal_immune_system1.07591775
72MP0002118_abnormal_lipid_homeostasis1.06609097
73MP0002098_abnormal_vibrissa_morphology1.06258403
74MP0002168_other_aberrant_phenotype1.05586211
75MP0003763_abnormal_thymus_physiology1.05508930
76MP0009931_abnormal_skin_appearance1.05219511
77MP0004197_abnormal_fetal_growth/weight/1.03600705
78MP0005220_abnormal_exocrine_pancreas1.03289977
79MP0003172_abnormal_lysosome_physiology1.02805645
80MP0000490_abnormal_crypts_of1.02731817
81MP0003453_abnormal_keratinocyte_physiol1.01153046
82MP0000604_amyloidosis1.00797892
83MP0002396_abnormal_hematopoietic_system0.99733186
84MP0003279_aneurysm0.99458150
85MP0000627_abnormal_mammary_gland0.98853671
86MP0000358_abnormal_cell_content/0.98804724
87MP0002796_impaired_skin_barrier0.98215472
88MP0000598_abnormal_liver_morphology0.97196883
89MP0005319_abnormal_enzyme/_coenzyme0.96484500
90MP0002086_abnormal_extraembryonic_tissu0.95900599
91MP0005332_abnormal_amino_acid0.95540817
92MP0003436_decreased_susceptibility_to0.95210412
93MP0000858_altered_metastatic_potential0.94052349
94MP0001944_abnormal_pancreas_morphology0.93933158
95MP0005174_abnormal_tail_pigmentation0.93253198
96MP0010094_abnormal_chromosome_stability0.93219783
97MP0005197_abnormal_uvea_morphology0.92765794
98MP0008007_abnormal_cellular_replicative0.92619147
99MP0005464_abnormal_platelet_physiology0.91717396
100MP0003984_embryonic_growth_retardation0.90537123
101MP0000733_abnormal_muscle_development0.90229497
102MP0003283_abnormal_digestive_organ0.90190932
103MP0005670_abnormal_white_adipose0.90129783
104MP0001835_abnormal_antigen_presentation0.88609570
105MP0002060_abnormal_skin_morphology0.87839427
106MP0006082_CNS_inflammation0.87740565
107MP0002136_abnormal_kidney_physiology0.87554650
108MP0002080_prenatal_lethality0.87487206
109MP0001919_abnormal_reproductive_system0.87401297
110MP0004272_abnormal_basement_membrane0.87394434
111MP0001661_extended_life_span0.86327865
112MP0005167_abnormal_blood-brain_barrier0.86124101
113MP0002088_abnormal_embryonic_growth/wei0.86033648
114MP0002896_abnormal_bone_mineralization0.85481488
115MP0002078_abnormal_glucose_homeostasis0.85220721
116MP0000350_abnormal_cell_proliferation0.85134792
117MP0001730_embryonic_growth_arrest0.84751692
118MP0000371_diluted_coat_color0.84506488
119MP0004858_abnormal_nervous_system0.84203481
120MP0005380_embryogenesis_phenotype0.84200458
121MP0001672_abnormal_embryogenesis/_devel0.84200458
122MP0002928_abnormal_bile_duct0.83959331
123MP0001873_stomach_inflammation0.83648165
124MP0005623_abnormal_meninges_morphology0.83628622
125MP0005621_abnormal_cell_physiology0.83531004
126MP0001915_intracranial_hemorrhage0.83280333
127MP0001881_abnormal_mammary_gland0.81740035
128MP0004510_myositis0.81352887
129MP0010155_abnormal_intestine_physiology0.80600192
130MP0001533_abnormal_skeleton_physiology0.79893403
131MP0009384_cardiac_valve_regurgitation0.78707382
132MP0001845_abnormal_inflammatory_respons0.77933470
133MP0003136_yellow_coat_color0.77901819
134MP0000767_abnormal_smooth_muscle0.74731111
135MP0003195_calcinosis0.74634761
136MP0002452_abnormal_antigen_presenting0.74401084
137MP0003075_altered_response_to0.74010716
138MP0004808_abnormal_hematopoietic_stem0.73857235
139MP0002089_abnormal_postnatal_growth/wei0.73482218
140MP0002006_tumorigenesis0.73443800
141MP0005397_hematopoietic_system_phenotyp0.73360657
142MP0001545_abnormal_hematopoietic_system0.73360657
143MP0009780_abnormal_chondrocyte_physiolo0.73154471
144MP0003221_abnormal_cardiomyocyte_apopto0.72728648
145MP0000427_abnormal_hair_cycle0.72680257
146MP0009115_abnormal_fat_cell0.72445592
147MP0003806_abnormal_nucleotide_metabolis0.72411669
148MP0005257_abnormal_intraocular_pressure0.72119162
149MP0000313_abnormal_cell_death0.71736469
150MP0001790_abnormal_immune_system0.71651845
151MP0005387_immune_system_phenotype0.71651845
152MP0002693_abnormal_pancreas_physiology0.71603601
153MP0001800_abnormal_humoral_immune0.71502666
154MP0000538_abnormal_urinary_bladder0.71326900
155MP0002971_abnormal_brown_adipose0.71288950
156MP0003828_pulmonary_edema0.71011004
157MP0002332_abnormal_exercise_endurance0.70639589
158MP0005384_cellular_phenotype0.70327610
159MP0005310_abnormal_salivary_gland0.69456867
160MP0003448_altered_tumor_morphology0.69168773
161MP0002269_muscular_atrophy0.69159878

Predicted human phenotypes

RankGene SetZ-score
1Entropion (HP:0000621)4.09342084
2Cerebral aneurysm (HP:0004944)3.64286175
3Deep venous thrombosis (HP:0002625)3.60318520
4Asymmetry of the thorax (HP:0001555)3.26910772
5Poikiloderma (HP:0001029)3.15157041
6Termporal pattern (HP:0011008)3.09023195
7Insidious onset (HP:0003587)3.09023195
8Protrusio acetabuli (HP:0003179)2.93493589
9Hypoglycemic coma (HP:0001325)2.91855103
10Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.89593991
11Sparse lateral eyebrow (HP:0005338)2.85769720
12Complement deficiency (HP:0004431)2.70202637
13Testicular atrophy (HP:0000029)2.66544658
14Hematochezia (HP:0002573)2.61901097
15Aortic aneurysm (HP:0004942)2.58459402
16Xanthomatosis (HP:0000991)2.56247836
17Long toe (HP:0010511)2.55164624
18Aneurysm (HP:0002617)2.54468557
19Urinary glycosaminoglycan excretion (HP:0003541)2.52140887
20Mucopolysacchariduria (HP:0008155)2.52140887
21Abnormality of the distal phalanges of the toes (HP:0010182)2.51659485
22Shallow orbits (HP:0000586)2.50942056
23Myocardial infarction (HP:0001658)2.49404843
24Hand muscle atrophy (HP:0009130)2.46482460
25Abnormality of the common coagulation pathway (HP:0010990)2.46081591
26Dysostosis multiplex (HP:0000943)2.43814272
27Mitral valve prolapse (HP:0001634)2.43596357
28Striae distensae (HP:0001065)2.43330933
29Enlarged penis (HP:0000040)2.43290603
30Persistence of primary teeth (HP:0006335)2.41188082
31Abnormality of polysaccharide metabolism (HP:0011012)2.40249997
32Abnormality of glycosaminoglycan metabolism (HP:0004371)2.40249997
33Abnormality of mucopolysaccharide metabolism (HP:0011020)2.40249997
34Long palpebral fissure (HP:0000637)2.38436256
35Premature rupture of membranes (HP:0001788)2.36011683
36Distal upper limb amyotrophy (HP:0007149)2.33505912
37Upper limb amyotrophy (HP:0009129)2.33505912
38Ankle contracture (HP:0006466)2.32688745
39Aortic dissection (HP:0002647)2.31608725
40Hyperglycemia (HP:0003074)2.31532867
41Patellar dislocation (HP:0002999)2.31262327
42Type II lissencephaly (HP:0007260)2.31126964
43Short nail (HP:0001799)2.30882019
44Personality changes (HP:0000751)2.27561975
45Elfin facies (HP:0004428)2.27213022
46Broad face (HP:0000283)2.26288203
47Insomnia (HP:0100785)2.25662699
48Cutaneous melanoma (HP:0012056)2.25125356
49Mitral stenosis (HP:0001718)2.24665190
50Renovascular hypertension (HP:0100817)2.24490900
51Cervical subluxation (HP:0003308)2.24331760
52Peritonitis (HP:0002586)2.23336478
53Micronodular cirrhosis (HP:0001413)2.23067193
54Abnormality of monocarboxylic acid metabolism (HP:0010996)2.20950393
55Increased cerebral lipofuscin (HP:0011813)2.18085878
56Pelvic girdle muscle weakness (HP:0003749)2.17707415
57Bilateral sensorineural hearing impairment (HP:0008619)2.17433192
58Abnormality of the intrinsic pathway (HP:0010989)2.16891611
59Partial agenesis of the corpus callosum (HP:0001338)2.16666956
60Ketoacidosis (HP:0001993)2.16654911
61Spina bifida occulta (HP:0003298)2.15347708
62Natal tooth (HP:0000695)2.14063972
63Dilatation of the ascending aorta (HP:0005111)2.12025893
64Abnormality of the pons (HP:0007361)2.11734038
65Cerebellar dysplasia (HP:0007033)2.11687686
66Abnormality of complement system (HP:0005339)2.10587734
67Polycythemia (HP:0001901)2.09864329
68Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.09440591
69Esophageal varix (HP:0002040)2.08809718
70Hyperacusis (HP:0010780)2.08314597
71Vertebral compression fractures (HP:0002953)2.07006975
72Intrahepatic cholestasis (HP:0001406)2.06193659
73Ketosis (HP:0001946)2.05737564
74Subacute progressive viral hepatitis (HP:0006572)2.05178498
75Hypoplasia of the pons (HP:0012110)2.04697453
76Abnormality of the distal phalanx of the thumb (HP:0009617)2.04224064
77Interstitial pulmonary disease (HP:0006530)2.02862827
78Overriding aorta (HP:0002623)2.01925771
79Asymmetric septal hypertrophy (HP:0001670)2.01038212
80Squamous cell carcinoma (HP:0002860)2.00533478
81Right ventricular cardiomyopathy (HP:0011663)1.99169727
82Broad metatarsal (HP:0001783)1.99075430
83Pseudobulbar signs (HP:0002200)1.98272937
84Fatigue (HP:0012378)1.98126880
85Abnormality of aromatic amino acid family metabolism (HP:0004338)1.96690326
86Thin bony cortex (HP:0002753)1.96546496
87Abnormal hair laboratory examination (HP:0003328)1.96530026
88Flat occiput (HP:0005469)1.96149940
89Germ cell neoplasia (HP:0100728)1.96042690
90Multiple lipomas (HP:0001012)1.95024984
91Ulnar bowing (HP:0003031)1.94792604
92Deep palmar crease (HP:0006191)1.94483923
93Late onset (HP:0003584)1.93904340
94Deformed sella turcica (HP:0002681)1.93650640
95Lymphangioma (HP:0100764)1.93017622
96Abnormality of the fingertips (HP:0001211)1.92773903
97Syringomyelia (HP:0003396)1.92591504
98Spinal cord lesions (HP:0100561)1.92591504
99Dysmetric saccades (HP:0000641)1.92507383
100Hypoglycemic seizures (HP:0002173)1.91811054
101Camptodactyly of toe (HP:0001836)1.90897580
102Increased neuronal autofluorescent lipopigment (HP:0002074)1.90482664
103Abnormality of glutamine family amino acid metabolism (HP:0010902)1.90435978
104Increased connective tissue (HP:0009025)1.89533124
105Renal duplication (HP:0000075)1.88425701
106Hyperinsulinemic hypoglycemia (HP:0000825)1.88165148
107Spastic diplegia (HP:0001264)1.87176176
108Prominent nose (HP:0000448)1.86575872
109Gout (HP:0001997)1.86054186
110Skin nodule (HP:0200036)1.85890218
111Systemic lupus erythematosus (HP:0002725)1.85272352
112Hyperparathyroidism (HP:0000843)1.85270614
113Insulin resistance (HP:0000855)1.83756702
114Abnormality of the nasal mucosa (HP:0000433)1.83639300
115Achilles tendon contracture (HP:0001771)1.83390068
116Flat cornea (HP:0007720)1.82879866
117Breast hypoplasia (HP:0003187)1.82797357
118IgA deficiency (HP:0002720)1.82316955
119Abnormality of the radial head (HP:0003995)1.81377594
120Cortical dysplasia (HP:0002539)1.81342609
121Dislocated radial head (HP:0003083)1.79908980
122Curly hair (HP:0002212)1.79608554
123Shoulder girdle muscle weakness (HP:0003547)1.79354419
124Melanoma (HP:0002861)1.79040916
125Rectal prolapse (HP:0002035)1.78662322
126Aplasia/Hypoplasia of the brainstem (HP:0007362)1.77346398
127Hypoplasia of the brainstem (HP:0002365)1.77346398
128Back pain (HP:0003418)1.77149000
129Genu recurvatum (HP:0002816)1.76997293
130Arterial tortuosity (HP:0005116)1.76955708
131Aplasia/hypoplasia of the humerus (HP:0006507)1.76828377
132Flat acetabular roof (HP:0003180)1.76709888
133Unilateral renal agenesis (HP:0000122)1.76168124
134Hypoalphalipoproteinemia (HP:0003233)1.75806634
135Severe short stature (HP:0003510)1.74964206
136Spontaneous hematomas (HP:0007420)1.73472206
137Abnormal ossification of hand bones (HP:0005921)1.73156375
138Coarse hair (HP:0002208)1.72533800
139Abnormal glucose tolerance (HP:0001952)1.72187739
140Increased CSF protein (HP:0002922)1.71780971
141Abnormal cartilage morphology (HP:0002763)1.71286677
142Abnormality of the musculature of the pelvis (HP:0001469)1.70538373
143Abnormality of the hip-girdle musculature (HP:0001445)1.70538373
144Increased serum ferritin (HP:0003281)1.70144930
145Hyperammonemia (HP:0001987)1.69975448
146Severe muscular hypotonia (HP:0006829)1.68803226
147Osteolytic defects of the hand bones (HP:0009699)1.68618650
148Osteolytic defects of the phalanges of the hand (HP:0009771)1.68618650
149Progressive hearing impairment (HP:0001730)1.68414611
150Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.68401041
151Bladder diverticulum (HP:0000015)1.68363520
152Nasal polyposis (HP:0100582)1.68020302
153Global brain atrophy (HP:0002283)1.67844431
154Colitis (HP:0002583)1.67345171
155Pili torti (HP:0003777)1.67183219
156Vascular tortuosity (HP:0004948)1.66686929
157Insulin-resistant diabetes mellitus (HP:0000831)1.66543834
158Hemorrhage of the eye (HP:0011885)1.65412087
159Orthostatic hypotension (HP:0001278)1.65205207
160Abnormality of proline metabolism (HP:0010907)1.64887653
161Hydroxyprolinuria (HP:0003080)1.64887653
162Increased density of long bones (HP:0006392)1.64808771
163Elevated alkaline phosphatase (HP:0003155)1.64691502
164Septate vagina (HP:0001153)1.64537008
165Deviation of the thumb (HP:0009603)1.64119253
166Limb-girdle muscle atrophy (HP:0003797)1.63665016
167Flattened epiphyses (HP:0003071)1.63327456
168Abnormality of purine metabolism (HP:0004352)1.63322907
169Increased mean platelet volume (HP:0011877)1.63223112
170Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.63140880
171Bowel diverticulosis (HP:0005222)1.62712438
172Sandal gap (HP:0001852)1.62485444
173Abnormality of the lower motor neuron (HP:0002366)1.62447359
174Short humerus (HP:0005792)1.61109730
175Nephritis (HP:0000123)1.60401816
176Difficulty climbing stairs (HP:0003551)1.60186832
177Spondylolisthesis (HP:0003302)1.59520898
178Patellar aplasia (HP:0006443)1.59480805
179Hepatitis (HP:0012115)1.59476030
180Basal cell carcinoma (HP:0002671)1.59105935
181Atrophic scars (HP:0001075)1.59078400
182Abnormality of oral frenula (HP:0000190)1.58871814
183Dysautonomia (HP:0002459)1.58312624
184Viral hepatitis (HP:0006562)1.58147485
185Meningioma (HP:0002858)1.57507913
186Hepatocellular carcinoma (HP:0001402)1.56957151
187Hallux valgus (HP:0001822)1.56338467
188Hypolipoproteinemia (HP:0010981)1.55610175

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB35.27817875
2PKN23.72612610
3ICK3.39806805
4ERN13.20997597
5EEF2K2.81945292
6IRAK32.61295212
7SMG12.53886652
8FGFR42.45854089
9PRPF4B2.37488708
10BRD42.24821457
11SIK12.23961792
12MAP3K102.18905983
13PDGFRA2.11626772
14PTK62.07987717
15TTN2.07981682
16TSSK62.03095899
17RIPK11.90608347
18MAP4K11.87575572
19STK101.84830864
20TGFBR21.82631329
21LATS11.70541554
22FRK1.68737686
23SCYL21.64410020
24LRRK21.56244062
25STK161.55311610
26SRPK11.52987046
27EPHB11.52280422
28JAK11.49657419
29FGFR31.39685195
30MAP3K141.36303614
31TESK21.35444295
32PIM21.30240732
33TYK21.28084924
34KSR21.26329234
35PASK1.26324263
36PRKD31.25358407
37JAK31.23499307
38RET1.21968163
39PTK21.21555335
40NEK91.20405709
41BRSK21.20110804
42EIF2AK21.18632521
43SIK21.18201578
44FLT31.17699722
45ZAP701.17060181
46EPHA31.16254256
47PAK41.14852478
48TAOK31.13601426
49TBK11.13454655
50RPS6KB21.11048412
51PRKCH1.09554920
52MAPKAPK31.02427494
53BCKDK1.02273222
54CAMK1D1.01997159
55IRAK40.97482596
56JAK20.96998439
57MAPK150.96721588
58CDK70.95165356
59MST1R0.95156213
60FGFR20.94683322
61WEE10.94463012
62RPS6KA40.92395420
63CSK0.91789380
64STK30.91520641
65CAMKK10.87980879
66CDK60.87965374
67TAOK10.86680131
68MAP2K30.84574345
69MET0.83898907
70DYRK1B0.83577611
71RPS6KA20.83238749
72DDR20.79260488
73MTOR0.78141599
74PDGFRB0.78082750
75NEK60.76521686
76ITK0.75498222
77TESK10.75230746
78LATS20.74771913
79YES10.73559549
80RAF10.71781789
81LMTK20.71721420
82MAP3K20.71521662
83ALK0.68456868
84NTRK10.68402436
85MAP3K80.68368311
86BMX0.67040644
87MAP2K10.66158074
88CDK120.64291676
89MAP3K30.64136449
90MOS0.64110569
91EPHA20.63060667
92GRK60.62838709
93FER0.62643774
94PRKCI0.62432177
95KDR0.62379967
96PAK30.62104509
97MAP3K70.60553726
98NEK20.60458633
99SIK30.59329788
100TAOK20.59192344
101MARK20.56426506
102MAP2K20.56219496
103CAMK1G0.56061287
104MAPK110.55734539
105NEK10.54829342
106TLK10.54634203
107RPS6KA10.54067268
108PAK20.53843045
109CHUK0.52692009
110TYRO30.52688736
111PDK10.51843427
112HIPK20.51190809
113PDK30.49476613
114PDK40.49476613
115FGFR10.47981963
116PAK60.45975429
117MAP3K10.45279960
118BLK0.43993472
119CSF1R0.43991585
120TRPM70.43667191
121SGK30.43400171
122PRKD10.42064928
123RPS6KB10.40985854
124RPS6KA50.40982729
125ILK0.40794861
126CDK40.40783558
127PDPK10.39660025
128MAP3K90.38783375
129MAPK90.38744330
130PRKD20.37954434
131INSRR0.37413000
132HCK0.37324561
133DMPK0.37188844
134TTK0.36833884
135IRAK10.36818880
136BRSK10.36615900
137EGFR0.35354054
138AKT20.35341536
139RPS6KL10.34451637
140RPS6KC10.34451637
141PNCK0.34426832
142CHEK20.34371791
143IKBKE0.34205242

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.49527802
2Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.39020955
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.36495973
4Nitrogen metabolism_Homo sapiens_hsa009102.25861725
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.91359933
6Fatty acid degradation_Homo sapiens_hsa000711.89498923
7Caffeine metabolism_Homo sapiens_hsa002321.81041977
8Maturity onset diabetes of the young_Homo sapiens_hsa049501.78885611
9Tryptophan metabolism_Homo sapiens_hsa003801.76016346
10Arginine biosynthesis_Homo sapiens_hsa002201.73242100
11Primary bile acid biosynthesis_Homo sapiens_hsa001201.70991411
12Selenocompound metabolism_Homo sapiens_hsa004501.69078624
13Cyanoamino acid metabolism_Homo sapiens_hsa004601.62764550
142-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.57517134
15Staphylococcus aureus infection_Homo sapiens_hsa051501.57277586
16Thyroid cancer_Homo sapiens_hsa052161.53988981
17Complement and coagulation cascades_Homo sapiens_hsa046101.53708206
18Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.49099050
19Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.47844107
20PPAR signaling pathway_Homo sapiens_hsa033201.46013191
21Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.42713416
22Chronic myeloid leukemia_Homo sapiens_hsa052201.39469554
23Insulin resistance_Homo sapiens_hsa049311.39422616
24Glycosaminoglycan degradation_Homo sapiens_hsa005311.32322232
25Pancreatic cancer_Homo sapiens_hsa052121.28357319
26Fatty acid metabolism_Homo sapiens_hsa012121.27555695
27MicroRNAs in cancer_Homo sapiens_hsa052061.26757432
28Sphingolipid metabolism_Homo sapiens_hsa006001.26521425
29Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.26434031
30Fructose and mannose metabolism_Homo sapiens_hsa000511.23074835
31NF-kappa B signaling pathway_Homo sapiens_hsa040641.23006073
32Hepatitis C_Homo sapiens_hsa051601.20955954
33RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.20754446
34Lysosome_Homo sapiens_hsa041421.18969290
35Lysine degradation_Homo sapiens_hsa003101.16141890
36Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.12286552
37N-Glycan biosynthesis_Homo sapiens_hsa005101.12276499
38Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.10674982
39Small cell lung cancer_Homo sapiens_hsa052221.09784164
40Adipocytokine signaling pathway_Homo sapiens_hsa049201.08715502
41ErbB signaling pathway_Homo sapiens_hsa040121.05488252
42Influenza A_Homo sapiens_hsa051641.04990495
43Bile secretion_Homo sapiens_hsa049761.04855644
44Focal adhesion_Homo sapiens_hsa045101.04203692
45Systemic lupus erythematosus_Homo sapiens_hsa053221.03753534
46mTOR signaling pathway_Homo sapiens_hsa041501.03713172
47Propanoate metabolism_Homo sapiens_hsa006401.02514121
48Fat digestion and absorption_Homo sapiens_hsa049751.02460618
49Toxoplasmosis_Homo sapiens_hsa051451.02038996
50Measles_Homo sapiens_hsa051621.00860625
51Prostate cancer_Homo sapiens_hsa052151.00549658
52Toll-like receptor signaling pathway_Homo sapiens_hsa046200.99813471
53Alcoholism_Homo sapiens_hsa050340.98158021
54Antigen processing and presentation_Homo sapiens_hsa046120.97582697
55Thyroid hormone signaling pathway_Homo sapiens_hsa049190.97340524
56Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.97339650
57Notch signaling pathway_Homo sapiens_hsa043300.97206272
58Leukocyte transendothelial migration_Homo sapiens_hsa046700.95061079
59Estrogen signaling pathway_Homo sapiens_hsa049150.93783410
60Adherens junction_Homo sapiens_hsa045200.93003092
61Amoebiasis_Homo sapiens_hsa051460.90137992
62Bladder cancer_Homo sapiens_hsa052190.89979998
63Spliceosome_Homo sapiens_hsa030400.89337627
64Other glycan degradation_Homo sapiens_hsa005110.89014576
65Pentose and glucuronate interconversions_Homo sapiens_hsa000400.88416995
66Prolactin signaling pathway_Homo sapiens_hsa049170.87857537
67Herpes simplex infection_Homo sapiens_hsa051680.87466299
68VEGF signaling pathway_Homo sapiens_hsa043700.86846448
69Non-small cell lung cancer_Homo sapiens_hsa052230.86615245
70Proteoglycans in cancer_Homo sapiens_hsa052050.86312426
71mRNA surveillance pathway_Homo sapiens_hsa030150.85658590
72Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.85438200
73B cell receptor signaling pathway_Homo sapiens_hsa046620.83321268
74Starch and sucrose metabolism_Homo sapiens_hsa005000.83003304
75Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.82558840
76Endometrial cancer_Homo sapiens_hsa052130.82150957
77Osteoclast differentiation_Homo sapiens_hsa043800.82037279
78AMPK signaling pathway_Homo sapiens_hsa041520.81926096
79Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.80495839
80AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.79629330
81Carbon metabolism_Homo sapiens_hsa012000.79398409
82Jak-STAT signaling pathway_Homo sapiens_hsa046300.78525846
83Inositol phosphate metabolism_Homo sapiens_hsa005620.78312002
84Carbohydrate digestion and absorption_Homo sapiens_hsa049730.77173501
85Insulin signaling pathway_Homo sapiens_hsa049100.76431524
86ABC transporters_Homo sapiens_hsa020100.76079539
87Central carbon metabolism in cancer_Homo sapiens_hsa052300.75939970
88Type II diabetes mellitus_Homo sapiens_hsa049300.75636876
89Butanoate metabolism_Homo sapiens_hsa006500.74517614
90Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.74487779
91Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.74211807
92Leishmaniasis_Homo sapiens_hsa051400.73325020
93Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.72479958
94Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.72037722
95Epstein-Barr virus infection_Homo sapiens_hsa051690.71952281
96Biosynthesis of amino acids_Homo sapiens_hsa012300.71854500
97Neurotrophin signaling pathway_Homo sapiens_hsa047220.71244348
98Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.71215139
99Fatty acid biosynthesis_Homo sapiens_hsa000610.69917163
100Sphingolipid signaling pathway_Homo sapiens_hsa040710.68608689
101Legionellosis_Homo sapiens_hsa051340.67448375
102Apoptosis_Homo sapiens_hsa042100.67148666
103Intestinal immune network for IgA production_Homo sapiens_hsa046720.66506770
104Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.65723055
105Acute myeloid leukemia_Homo sapiens_hsa052210.65680804
106NOD-like receptor signaling pathway_Homo sapiens_hsa046210.65673256
107Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.65371060
108Nucleotide excision repair_Homo sapiens_hsa034200.64831183
109Longevity regulating pathway - mammal_Homo sapiens_hsa042110.64546890
110Platelet activation_Homo sapiens_hsa046110.63597092
111Glucagon signaling pathway_Homo sapiens_hsa049220.63162682
112Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.62525960
113Non-homologous end-joining_Homo sapiens_hsa034500.61891552
114Pyruvate metabolism_Homo sapiens_hsa006200.61765348
115Pathways in cancer_Homo sapiens_hsa052000.61313451
116Glycerolipid metabolism_Homo sapiens_hsa005610.61085115
117Melanoma_Homo sapiens_hsa052180.61039534
118beta-Alanine metabolism_Homo sapiens_hsa004100.60959426
119ECM-receptor interaction_Homo sapiens_hsa045120.60921392
120Viral myocarditis_Homo sapiens_hsa054160.60743568
121Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.60697706
122Prion diseases_Homo sapiens_hsa050200.60640101
123HTLV-I infection_Homo sapiens_hsa051660.60415582
124Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.59602191
125Hepatitis B_Homo sapiens_hsa051610.59573842
126Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.59561609
127TNF signaling pathway_Homo sapiens_hsa046680.59103470
128Tuberculosis_Homo sapiens_hsa051520.58913134
129Glioma_Homo sapiens_hsa052140.58200368
130Drug metabolism - other enzymes_Homo sapiens_hsa009830.57853974
131Transcriptional misregulation in cancer_Homo sapiens_hsa052020.57738833
132Colorectal cancer_Homo sapiens_hsa052100.57033564
133One carbon pool by folate_Homo sapiens_hsa006700.56900067
134Endocytosis_Homo sapiens_hsa041440.56336926
135Shigellosis_Homo sapiens_hsa051310.56085857
136HIF-1 signaling pathway_Homo sapiens_hsa040660.54783518
137T cell receptor signaling pathway_Homo sapiens_hsa046600.53890072
138Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.52779962
139Hippo signaling pathway_Homo sapiens_hsa043900.52454061
140Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.52213925
141Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.50734441
142FoxO signaling pathway_Homo sapiens_hsa040680.48902042
143Phenylalanine metabolism_Homo sapiens_hsa003600.48676378
144Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.48549683
145Renal cell carcinoma_Homo sapiens_hsa052110.48430577
146Histidine metabolism_Homo sapiens_hsa003400.48063057
147Viral carcinogenesis_Homo sapiens_hsa052030.48056733
148Peroxisome_Homo sapiens_hsa041460.47416925
149Renin-angiotensin system_Homo sapiens_hsa046140.46460396

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