DNAJC17

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.74677591
2DNA strand elongation involved in DNA replication (GO:0006271)4.74308568
3DNA strand elongation (GO:0022616)4.51150681
4formation of translation preinitiation complex (GO:0001731)4.38685338
5DNA replication initiation (GO:0006270)4.35015053
6telomere maintenance via semi-conservative replication (GO:0032201)4.31660687
7nucleobase biosynthetic process (GO:0046112)4.26391447
8DNA replication checkpoint (GO:0000076)4.22504962
9metallo-sulfur cluster assembly (GO:0031163)4.13731048
10iron-sulfur cluster assembly (GO:0016226)4.13731048
11telomere maintenance via recombination (GO:0000722)4.08423079
12purine nucleobase biosynthetic process (GO:0009113)4.05653299
13maturation of SSU-rRNA (GO:0030490)4.04442352
14mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.00092578
15base-excision repair, AP site formation (GO:0006285)3.98450328
16proteasome assembly (GO:0043248)3.96577271
17chaperone-mediated protein transport (GO:0072321)3.95269810
18ribosomal small subunit assembly (GO:0000028)3.91979984
19establishment of protein localization to mitochondrial membrane (GO:0090151)3.90523916
20mitotic metaphase plate congression (GO:0007080)3.86413210
21DNA unwinding involved in DNA replication (GO:0006268)3.83870813
22mitotic recombination (GO:0006312)3.81903509
23pseudouridine synthesis (GO:0001522)3.72752759
24ribosome biogenesis (GO:0042254)3.72482540
25ATP synthesis coupled proton transport (GO:0015986)3.71078669
26energy coupled proton transport, down electrochemical gradient (GO:0015985)3.71078669
27protein complex biogenesis (GO:0070271)3.67404424
28mitochondrial respiratory chain complex I assembly (GO:0032981)3.65997042
29NADH dehydrogenase complex assembly (GO:0010257)3.65997042
30mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.65997042
31respiratory chain complex IV assembly (GO:0008535)3.62823308
32protein localization to kinetochore (GO:0034501)3.62281000
33telomere maintenance via telomere lengthening (GO:0010833)3.57228702
34platelet dense granule organization (GO:0060155)3.57103812
35mitochondrial respiratory chain complex assembly (GO:0033108)3.55385504
36deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.53047400
37regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.52060603
38CENP-A containing nucleosome assembly (GO:0034080)3.51621179
39rRNA modification (GO:0000154)3.50899425
40ribonucleoprotein complex biogenesis (GO:0022613)3.49114725
41negative regulation of telomere maintenance (GO:0032205)3.48322301
42mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.47555882
43spliceosomal snRNP assembly (GO:0000387)3.47454425
44maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.46407177
45chromatin remodeling at centromere (GO:0031055)3.43678680
46pyrimidine nucleotide catabolic process (GO:0006244)3.43454115
47viral mRNA export from host cell nucleus (GO:0046784)3.43155760
48negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.42271108
49protein deneddylation (GO:0000338)3.40720308
50water-soluble vitamin biosynthetic process (GO:0042364)3.37261236
51ribosomal large subunit biogenesis (GO:0042273)3.36505743
52tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.35214863
53RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.35214863
54rRNA processing (GO:0006364)3.34665798
55anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.32865874
56nucleotide-excision repair, DNA gap filling (GO:0006297)3.31507924
57regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.30968723
58cullin deneddylation (GO:0010388)3.30885886
59kinetochore assembly (GO:0051382)3.30429506
60cytochrome complex assembly (GO:0017004)3.29950046
61positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.27912962
62DNA replication-independent nucleosome assembly (GO:0006336)3.27661567
63DNA replication-independent nucleosome organization (GO:0034724)3.27661567
64mitotic nuclear envelope disassembly (GO:0007077)3.25573190
65regulation of nuclear cell cycle DNA replication (GO:0033262)3.24800547
66ribosomal small subunit biogenesis (GO:0042274)3.24007810
67respiratory electron transport chain (GO:0022904)3.23688386
68rRNA metabolic process (GO:0016072)3.23452625
69electron transport chain (GO:0022900)3.23321180
70intra-S DNA damage checkpoint (GO:0031573)3.22833736
71kinetochore organization (GO:0051383)3.21683971
72viral transcription (GO:0019083)3.21140039
73metaphase plate congression (GO:0051310)3.20377449
74histone H2A acetylation (GO:0043968)3.19761338
75regulation of double-strand break repair via homologous recombination (GO:0010569)3.19170130
76maturation of 5.8S rRNA (GO:0000460)3.18647530
77translational initiation (GO:0006413)3.18240386
78preassembly of GPI anchor in ER membrane (GO:0016254)3.16545289
79L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.16538593
80regulation of cellular amino acid metabolic process (GO:0006521)3.16202281
81aggressive behavior (GO:0002118)3.15767820
82termination of RNA polymerase III transcription (GO:0006386)3.15545146
83transcription elongation from RNA polymerase III promoter (GO:0006385)3.15545146
84translational termination (GO:0006415)3.15461849
85autophagic vacuole fusion (GO:0000046)3.15045452
86replication fork processing (GO:0031297)3.14510759
87transcription-coupled nucleotide-excision repair (GO:0006283)3.14185295
88IMP biosynthetic process (GO:0006188)3.13731964
89spliceosomal complex assembly (GO:0000245)3.09287542
90mannosylation (GO:0097502)3.09233036
91tRNA methylation (GO:0030488)3.08744921
92negative regulation of ligase activity (GO:0051352)3.08646954
93negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.08646954
94response to pheromone (GO:0019236)3.08422645
95behavioral response to nicotine (GO:0035095)3.04034797
96deoxyribonucleotide catabolic process (GO:0009264)3.03890856
97DNA replication-dependent nucleosome assembly (GO:0006335)3.03141353
98DNA replication-dependent nucleosome organization (GO:0034723)3.03141353
99protein-cofactor linkage (GO:0018065)3.02346993
100translational elongation (GO:0006414)3.01441302
101nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.00948508
102G1/S transition of mitotic cell cycle (GO:0000082)3.00856732
103cell cycle G1/S phase transition (GO:0044843)3.00856732
104GPI anchor biosynthetic process (GO:0006506)2.99970288
105signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.98841095
106signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.98841095
107signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.98841095
108DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.98471820
109protein localization to chromosome, centromeric region (GO:0071459)2.98315602
110intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.97716590
111signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.97716590
112establishment of chromosome localization (GO:0051303)2.96879694
1137-methylguanosine mRNA capping (GO:0006370)2.96371246
114signal transduction involved in cell cycle checkpoint (GO:0072395)2.96211693
115folic acid-containing compound biosynthetic process (GO:0009396)2.95996760
116signal transduction involved in DNA integrity checkpoint (GO:0072401)2.95917780
117signal transduction involved in DNA damage checkpoint (GO:0072422)2.95917780
118positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.95294598
119membrane disassembly (GO:0030397)2.94925691
120nuclear envelope disassembly (GO:0051081)2.94925691
121GPI anchor metabolic process (GO:0006505)2.94506011
122Arp2/3 complex-mediated actin nucleation (GO:0034314)2.94463127
123regulation of cytokine production involved in inflammatory response (GO:1900015)2.93425879
124telomere organization (GO:0032200)2.92327603
125pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.91887793
126telomere maintenance (GO:0000723)2.91465154
127exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.90963639
128RNA capping (GO:0036260)2.89013576
1297-methylguanosine RNA capping (GO:0009452)2.89013576
130ribosome assembly (GO:0042255)2.88994524
131negative regulation of chromosome segregation (GO:0051985)2.86526318
132deoxyribose phosphate catabolic process (GO:0046386)2.86118766
133DNA double-strand break processing (GO:0000729)2.85871443
134rRNA methylation (GO:0031167)2.85398055
135positive regulation of prostaglandin secretion (GO:0032308)2.85274066
136positive regulation of chromosome segregation (GO:0051984)2.84137678
137nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.83747028
138translation (GO:0006412)2.83629787
139somatic hypermutation of immunoglobulin genes (GO:0016446)2.82372738
140somatic diversification of immune receptors via somatic mutation (GO:0002566)2.82372738
141L-fucose catabolic process (GO:0042355)2.81863456
142fucose catabolic process (GO:0019317)2.81863456
143L-fucose metabolic process (GO:0042354)2.81863456
144C-terminal protein lipidation (GO:0006501)2.81355886
145organelle membrane fusion (GO:0090174)2.78009728
146cytidine metabolic process (GO:0046087)2.76247795
147cytidine catabolic process (GO:0006216)2.76247795
148cytidine deamination (GO:0009972)2.76247795
149peptidyl-histidine modification (GO:0018202)2.75768214
150GMP metabolic process (GO:0046037)2.74180186
151amino acid salvage (GO:0043102)2.72124674
152L-methionine salvage (GO:0071267)2.72124674
153L-methionine biosynthetic process (GO:0071265)2.72124674
154tRNA processing (GO:0008033)2.71755471
155pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.71410305
156DNA catabolic process, exonucleolytic (GO:0000738)2.69407365
157regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.69116297
158regulation of mitotic spindle checkpoint (GO:1903504)2.69116297
159protein targeting to mitochondrion (GO:0006626)2.67397072
160protein neddylation (GO:0045116)2.66595539
161ubiquinone biosynthetic process (GO:0006744)2.66364850
162establishment of protein localization to mitochondrion (GO:0072655)2.64590835
163cellular ketone body metabolic process (GO:0046950)2.62776451
164regulation of mitochondrial translation (GO:0070129)2.60597928
165actin nucleation (GO:0045010)2.59318263
166protein localization to mitochondrion (GO:0070585)2.55555198
167tRNA modification (GO:0006400)2.55406092

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.51643009
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.06045340
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.75152252
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.28873105
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.20786257
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.17359630
7E2F4_17652178_ChIP-ChIP_JURKAT_Human3.13688469
8ZNF274_21170338_ChIP-Seq_K562_Hela3.08976970
9GABP_17652178_ChIP-ChIP_JURKAT_Human3.07589822
10* ETS1_20019798_ChIP-Seq_JURKAT_Human3.04500230
11FOXM1_23109430_ChIP-Seq_U2OS_Human2.93463209
12MYC_18358816_ChIP-ChIP_MESCs_Mouse2.92108975
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.90515046
14MYC_19079543_ChIP-ChIP_MESCs_Mouse2.87572080
15MYC_19030024_ChIP-ChIP_MESCs_Mouse2.80535139
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.62798442
17* NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.62584499
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.58297705
19XRN2_22483619_ChIP-Seq_HELA_Human2.40566273
20VDR_23849224_ChIP-Seq_CD4+_Human2.36060184
21ELF1_17652178_ChIP-ChIP_JURKAT_Human2.31193579
22HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.29497577
23NELFA_20434984_ChIP-Seq_ESCs_Mouse2.22279092
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.21504047
25FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.11445177
26FOXP3_21729870_ChIP-Seq_TREG_Human2.10349462
27E2F1_18555785_ChIP-Seq_MESCs_Mouse2.10168087
28* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.08792606
29DCP1A_22483619_ChIP-Seq_HELA_Human2.04793307
30* THAP11_20581084_ChIP-Seq_MESCs_Mouse2.04032842
31GABP_19822575_ChIP-Seq_HepG2_Human2.02479975
32YY1_21170310_ChIP-Seq_MESCs_Mouse1.98361436
33CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.89011280
34SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.88636211
35MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.86379811
36E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.86224230
37MYCN_18555785_ChIP-Seq_MESCs_Mouse1.85565781
38TTF2_22483619_ChIP-Seq_HELA_Human1.84862376
39NANOG_18555785_ChIP-Seq_MESCs_Mouse1.84471277
40MYC_22102868_ChIP-Seq_BL_Human1.81091656
41E2F1_21310950_ChIP-Seq_MCF-7_Human1.78475980
42CIITA_25753668_ChIP-Seq_RAJI_Human1.77200990
43VDR_22108803_ChIP-Seq_LS180_Human1.76962494
44MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.75821190
45IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.73940936
46PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.70599588
47* SRF_21415370_ChIP-Seq_HL-1_Mouse1.68166383
48YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.67403800
49AR_21909140_ChIP-Seq_LNCAP_Human1.66411858
50SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.64688676
51POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.64327313
52FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.63709493
53TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.58185717
54KDM5A_27292631_Chip-Seq_BREAST_Human1.57781498
55ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.53455569
56* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.50300235
57HOXB4_20404135_ChIP-ChIP_EML_Mouse1.50253308
58ZFX_18555785_ChIP-Seq_MESCs_Mouse1.49486405
59ELK1_19687146_ChIP-ChIP_HELA_Human1.48055995
60IRF8_22096565_ChIP-ChIP_GC-B_Human1.47245076
61* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.45937188
62CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.43756993
63IGF1R_20145208_ChIP-Seq_DFB_Human1.41597357
64IRF8_21731497_ChIP-ChIP_J774_Mouse1.40118411
65MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.39954874
66PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.39567475
67EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.39144206
68TP53_22573176_ChIP-Seq_HFKS_Human1.37095016
69SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.36144735
70EGR1_19374776_ChIP-ChIP_THP-1_Human1.34744935
71BP1_19119308_ChIP-ChIP_Hs578T_Human1.34537771
72GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.34329961
73POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.29825894
74EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.29771872
75KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.29366707
76IRF1_19129219_ChIP-ChIP_H3396_Human1.27805578
77TP63_19390658_ChIP-ChIP_HaCaT_Human1.26954718
78STAT3_1855785_ChIP-Seq_MESCs_Mouse1.25473996
79POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.25420764
80FLI1_27457419_Chip-Seq_LIVER_Mouse1.23782709
81ERG_20887958_ChIP-Seq_HPC-7_Mouse1.23094954
82PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.22951243
83CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.22459136
84ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.21142711
85LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.19664977
86DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.19437821
87KLF4_18555785_ChIP-Seq_MESCs_Mouse1.18946083
88SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.18615858
89RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.18502099
90SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.16669209
91BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.14729318
92TFEB_21752829_ChIP-Seq_HELA_Human1.13592175
93NOTCH1_21737748_ChIP-Seq_TLL_Human1.12527895
94BCL6_27268052_Chip-Seq_Bcells_Human1.12479646
95RBPJ_22232070_ChIP-Seq_NCS_Mouse1.12056399
96VDR_21846776_ChIP-Seq_THP-1_Human1.11030489
97SOX2_18555785_ChIP-Seq_MESCs_Mouse1.08582102
98ELF1_20517297_ChIP-Seq_JURKAT_Human1.08318487
99ERA_21632823_ChIP-Seq_H3396_Human1.06351715
100CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.05866204
101* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.05755768
102* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.05020737
103EWS_26573619_Chip-Seq_HEK293_Human1.04405261
104KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.03685936
105TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.03005188
106CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.02957077
107ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.01380641
108NANOG_20526341_ChIP-Seq_ESCs_Human1.00745038
109PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.00743238
110AR_20517297_ChIP-Seq_VCAP_Human1.00062320
111DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.99642085
112MYC_19829295_ChIP-Seq_ESCs_Human0.99293285
113FOXA1_27270436_Chip-Seq_PROSTATE_Human0.97835601
114FOXA1_25329375_ChIP-Seq_VCAP_Human0.97835601
115PADI4_21655091_ChIP-ChIP_MCF-7_Human0.96349050
116MYC_18940864_ChIP-ChIP_HL60_Human0.96270304
117E2F1_20622854_ChIP-Seq_HELA_Human0.96201823
118CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.95695345
119KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.95289067
120SPI1_23547873_ChIP-Seq_NB4_Human0.95021806
121SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.94365485
122CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.94064931
123TAF2_19829295_ChIP-Seq_ESCs_Human0.92526902
124IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.92470458
125NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.92268850
126GATA3_26560356_Chip-Seq_TH2_Human0.92047423
127HTT_18923047_ChIP-ChIP_STHdh_Human0.91792352
128YY1_22570637_ChIP-Seq_MALME-3M_Human0.91771869
129GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.91522141
130MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.88810327
131CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.88548477
132TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.88529969
133CTBP1_25329375_ChIP-Seq_LNCAP_Human0.88015237
134PHF8_20622854_ChIP-Seq_HELA_Human0.87436866
135GATA3_21878914_ChIP-Seq_MCF-7_Human0.87406417
136ELK1_22589737_ChIP-Seq_MCF10A_Human0.87340748
137NANOG_21062744_ChIP-ChIP_HESCs_Human0.87143739
138TAF15_26573619_Chip-Seq_HEK293_Human0.84278038
139FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78566064
140* TBX5_21415370_ChIP-Seq_HL-1_Mouse0.78028924
141NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.77499535
142NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.77400361
143OCT4_18692474_ChIP-Seq_MEFs_Mouse0.76054259

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching6.00580517
2MP0004957_abnormal_blastocyst_morpholog4.60882182
3MP0003111_abnormal_nucleus_morphology4.49505434
4MP0010094_abnormal_chromosome_stability4.41299984
5MP0003077_abnormal_cell_cycle3.99683605
6MP0008057_abnormal_DNA_replication3.31325237
7MP0008058_abnormal_DNA_repair3.22677121
8MP0008932_abnormal_embryonic_tissue2.74751216
9MP0008007_abnormal_cellular_replicative2.70273861
10MP0002396_abnormal_hematopoietic_system2.65271433
11MP0005645_abnormal_hypothalamus_physiol2.62602886
12MP0000372_irregular_coat_pigmentation2.61381043
13MP0006292_abnormal_olfactory_placode2.26799284
14MP0005084_abnormal_gallbladder_morpholo2.18498569
15MP0008877_abnormal_DNA_methylation2.14552279
16MP0008875_abnormal_xenobiotic_pharmacok2.12727815
17MP0001968_abnormal_touch/_nociception2.09411478
18MP0003123_paternal_imprinting2.05712445
19MP0001730_embryonic_growth_arrest2.05602290
20MP0000490_abnormal_crypts_of2.02330346
21MP0003718_maternal_effect1.97929383
22MP0002148_abnormal_hypersensitivity_rea1.97696151
23MP0005387_immune_system_phenotype1.97244842
24MP0001790_abnormal_immune_system1.97244842
25MP0009785_altered_susceptibility_to1.97120433
26MP0000350_abnormal_cell_proliferation1.93000927
27MP0010352_gastrointestinal_tract_polyps1.90230206
28MP0002638_abnormal_pupillary_reflex1.86938670
29MP0002736_abnormal_nociception_after1.77228947
30MP0003763_abnormal_thymus_physiology1.76677985
31MP0003786_premature_aging1.71886845
32MP0010030_abnormal_orbit_morphology1.70050080
33MP0002132_abnormal_respiratory_system1.67441459
34MP0005075_abnormal_melanosome_morpholog1.65024755
35MP0001697_abnormal_embryo_size1.62310931
36MP0000313_abnormal_cell_death1.60898953
37MP0006072_abnormal_retinal_apoptosis1.60777908
38MP0008872_abnormal_physiological_respon1.57065191
39MP0005380_embryogenesis_phenotype1.57007995
40MP0001672_abnormal_embryogenesis/_devel1.57007995
41MP0001545_abnormal_hematopoietic_system1.56356996
42MP0005397_hematopoietic_system_phenotyp1.56356996
43MP0002019_abnormal_tumor_incidence1.49497880
44MP0003195_calcinosis1.48951643
45MP0004142_abnormal_muscle_tone1.48890377
46MP0009333_abnormal_splenocyte_physiolog1.44310000
47* MP0002080_prenatal_lethality1.43341896
48MP0003984_embryonic_growth_retardation1.42706712
49MP0008789_abnormal_olfactory_epithelium1.40631346
50MP0000703_abnormal_thymus_morphology1.38123686
51MP0002088_abnormal_embryonic_growth/wei1.37727583
52MP0002085_abnormal_embryonic_tissue1.37264722
53MP0002254_reproductive_system_inflammat1.37221707
54MP0005253_abnormal_eye_physiology1.36356159
55MP0003011_delayed_dark_adaptation1.35004975
56MP0003186_abnormal_redox_activity1.34966012
57MP0004808_abnormal_hematopoietic_stem1.33212412
58MP0002735_abnormal_chemical_nociception1.31433055
59MP0002398_abnormal_bone_marrow1.31343543
60MP0003436_decreased_susceptibility_to1.30856853
61MP0001984_abnormal_olfaction1.29640111
62MP0001529_abnormal_vocalization1.29293547
63MP0005551_abnormal_eye_electrophysiolog1.27968782
64MP0005499_abnormal_olfactory_system1.27763050
65MP0005394_taste/olfaction_phenotype1.27763050
66MP0010307_abnormal_tumor_latency1.26767051
67MP0002722_abnormal_immune_system1.25487587
68MP0000689_abnormal_spleen_morphology1.22888523
69MP0009046_muscle_twitch1.22162442
70MP0003646_muscle_fatigue1.21682800
71MP0002086_abnormal_extraembryonic_tissu1.21052622
72MP0005646_abnormal_pituitary_gland1.20800084
73MP0003183_abnormal_peptide_metabolism1.20700845
74MP0009764_decreased_sensitivity_to1.20112939
75MP0003890_abnormal_embryonic-extraembry1.18777826
76MP0002084_abnormal_developmental_patter1.18682319
77MP0000015_abnormal_ear_pigmentation1.18470827
78MP0002837_dystrophic_cardiac_calcinosis1.17891494
79MP0004147_increased_porphyrin_level1.16459332
80MP0001293_anophthalmia1.12590834
81MP0005025_abnormal_response_to1.12540700
82MP0006276_abnormal_autonomic_nervous1.11702249
83MP0003121_genomic_imprinting1.10761666
84MP0002095_abnormal_skin_pigmentation1.10503529
85MP0005174_abnormal_tail_pigmentation1.09635460
86MP0003806_abnormal_nucleotide_metabolis1.08525752
87MP0002822_catalepsy1.08301347
88MP0001905_abnormal_dopamine_level1.07977770
89MP0003221_abnormal_cardiomyocyte_apopto1.07562137
90MP0002163_abnormal_gland_morphology1.07017474
91MP0005000_abnormal_immune_tolerance1.05046669
92MP0002160_abnormal_reproductive_system1.04929562
93MP0002210_abnormal_sex_determination1.04458632
94MP0004133_heterotaxia1.01833520
95MP0002429_abnormal_blood_cell1.01325668
96MP0005410_abnormal_fertilization1.01017688
97MP0003315_abnormal_perineum_morphology0.99813911
98MP0003136_yellow_coat_color0.99746223
99MP0000358_abnormal_cell_content/0.99481024
100MP0008873_increased_physiological_sensi0.98973172
101MP0002733_abnormal_thermal_nociception0.98850245
102MP0001145_abnormal_male_reproductive0.97317443
103MP0001853_heart_inflammation0.96477724
104MP0001986_abnormal_taste_sensitivity0.96303713
105MP0000678_abnormal_parathyroid_gland0.96169115
106MP0002876_abnormal_thyroid_physiology0.95137858
107MP0001873_stomach_inflammation0.93920597
108MP0000716_abnormal_immune_system0.92403267
109MP0008995_early_reproductive_senescence0.92009486
110MP0005379_endocrine/exocrine_gland_phen0.91819308
111MP0004197_abnormal_fetal_growth/weight/0.91686600
112MP0002653_abnormal_ependyma_morphology0.89420513
113MP0001764_abnormal_homeostasis0.87703013
114MP0006082_CNS_inflammation0.86939269
115MP0003567_abnormal_fetal_cardiomyocyte0.86413735
116MP0001970_abnormal_pain_threshold0.85681536
117MP0005389_reproductive_system_phenotype0.84438217
118MP0002277_abnormal_respiratory_mucosa0.84364983
119MP0005670_abnormal_white_adipose0.83473649
120MP0000858_altered_metastatic_potential0.82723035
121MP0003880_abnormal_central_pattern0.82590307
122MP0001119_abnormal_female_reproductive0.82483826
123MP0006036_abnormal_mitochondrial_physio0.82135321
124MP0005332_abnormal_amino_acid0.80953746
125MP0000653_abnormal_sex_gland0.80862782
126MP0009278_abnormal_bone_marrow0.80701994
127MP0005423_abnormal_somatic_nervous0.79777710
128MP0005384_cellular_phenotype0.79341929
129MP0001324_abnormal_eye_pigmentation0.78980235
130MP0001929_abnormal_gametogenesis0.78333748
131MP0001845_abnormal_inflammatory_respons0.78065256
132MP0001800_abnormal_humoral_immune0.77829019
133MP0002272_abnormal_nervous_system0.76866492
134MP0001727_abnormal_embryo_implantation0.75981197
135MP0003119_abnormal_digestive_system0.74304866
136MP0009697_abnormal_copulation0.74144242
137MP0002420_abnormal_adaptive_immunity0.73412550
138MP0003787_abnormal_imprinting0.73175891
139MP0000685_abnormal_immune_system0.73072341
140MP0006035_abnormal_mitochondrial_morpho0.72967968
141MP0001819_abnormal_immune_cell0.72306828
142MP0002933_joint_inflammation0.72214815
143MP0002405_respiratory_system_inflammati0.71902664
144MP0008469_abnormal_protein_level0.71829085
145MP0001835_abnormal_antigen_presentation0.71656001
146MP0005671_abnormal_response_to0.69912516
147MP0005621_abnormal_cell_physiology0.68841773
148MP0002751_abnormal_autonomic_nervous0.66061019
149MP0003656_abnormal_erythrocyte_physiolo0.64947039
150MP0002723_abnormal_immune_serum0.60540635
151MP0002452_abnormal_antigen_presenting0.60520304
152MP0000537_abnormal_urethra_morphology0.60075131
153MP0002102_abnormal_ear_morphology0.60039883
154MP0009672_abnormal_birth_weight0.58757986
155MP0005310_abnormal_salivary_gland0.57371678
156MP0004264_abnormal_extraembryonic_tissu0.54827880
157MP0000477_abnormal_intestine_morphology0.54311625

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.99099759
2Acute necrotizing encephalopathy (HP:0006965)4.53015103
3Mitochondrial inheritance (HP:0001427)4.40448952
4Abnormal mitochondria in muscle tissue (HP:0008316)4.16073282
5Chromosomal breakage induced by crosslinking agents (HP:0003221)4.06038504
6Acute encephalopathy (HP:0006846)4.04566903
7Chromsome breakage (HP:0040012)4.02882031
8Increased CSF lactate (HP:0002490)3.94406149
9Breast hypoplasia (HP:0003187)3.87637633
10Reticulocytopenia (HP:0001896)3.84386564
11Progressive macrocephaly (HP:0004481)3.80932536
12Increased hepatocellular lipid droplets (HP:0006565)3.79471696
13Hepatocellular necrosis (HP:0001404)3.73009963
14Abnormality of cells of the erythroid lineage (HP:0012130)3.71407298
15Abnormal number of erythroid precursors (HP:0012131)3.67013270
16Lipid accumulation in hepatocytes (HP:0006561)3.64361223
17Patellar aplasia (HP:0006443)3.63859302
18Hepatic necrosis (HP:0002605)3.59467751
19Stomatitis (HP:0010280)3.48111881
20Cerebral hypomyelination (HP:0006808)3.46128791
21Aplastic anemia (HP:0001915)3.45388565
22Aplasia/Hypoplasia of the patella (HP:0006498)3.45253595
23Methylmalonic aciduria (HP:0012120)3.41350413
24Oral leukoplakia (HP:0002745)3.41281001
25Methylmalonic acidemia (HP:0002912)3.39903584
26Renal Fanconi syndrome (HP:0001994)3.39028671
27Degeneration of anterior horn cells (HP:0002398)3.34866504
28Abnormality of the anterior horn cell (HP:0006802)3.34866504
29Abnormality of the ileum (HP:0001549)3.32839293
30Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.13450016
31Decreased activity of mitochondrial respiratory chain (HP:0008972)3.13450016
32Meckel diverticulum (HP:0002245)3.06664636
33Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.03541179
34Increased intramyocellular lipid droplets (HP:0012240)2.99780511
35Cerebral edema (HP:0002181)2.97894740
36Carpal bone hypoplasia (HP:0001498)2.94391140
37Abnormality of midbrain morphology (HP:0002418)2.93692998
38Molar tooth sign on MRI (HP:0002419)2.93692998
39Congenital stationary night blindness (HP:0007642)2.89234028
40Rough bone trabeculation (HP:0100670)2.85275433
41Lactic acidosis (HP:0003128)2.84408656
42Multiple enchondromatosis (HP:0005701)2.83238507
43Abnormality of the preputium (HP:0100587)2.81084230
44Exertional dyspnea (HP:0002875)2.78163213
45Aplasia/Hypoplasia of the uvula (HP:0010293)2.76903176
46Absent thumb (HP:0009777)2.74179939
47Selective tooth agenesis (HP:0001592)2.72858966
48Premature graying of hair (HP:0002216)2.71823305
49Dicarboxylic aciduria (HP:0003215)2.71048367
50Abnormality of dicarboxylic acid metabolism (HP:0010995)2.71048367
51Colon cancer (HP:0003003)2.69557418
52Facial hemangioma (HP:0000329)2.68200542
53Ependymoma (HP:0002888)2.67818390
54Thrombocytosis (HP:0001894)2.66054314
55Pancreatic cysts (HP:0001737)2.63538755
56Abnormality of chromosome stability (HP:0003220)2.63057566
57Increased muscle lipid content (HP:0009058)2.62540009
58Aplasia/Hypoplasia of the sacrum (HP:0008517)2.62209912
59Bone marrow hypocellularity (HP:0005528)2.59144107
60Microretrognathia (HP:0000308)2.59084504
61Pallor (HP:0000980)2.54916399
62Ketosis (HP:0001946)2.53072708
63Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.51974051
64Volvulus (HP:0002580)2.51932235
65Myelodysplasia (HP:0002863)2.51626144
66Decreased electroretinogram (ERG) amplitude (HP:0000654)2.50280278
67IgG deficiency (HP:0004315)2.50000908
68Muscle fiber atrophy (HP:0100295)2.48826231
69Optic disc pallor (HP:0000543)2.45886590
70Generalized aminoaciduria (HP:0002909)2.40924162
71Abnormality of the aortic arch (HP:0012303)2.39391695
72Lethargy (HP:0001254)2.38461384
73Cleft eyelid (HP:0000625)2.33749419
74Respiratory failure (HP:0002878)2.31650720
75Type 2 muscle fiber atrophy (HP:0003554)2.31637881
76Neoplasm of the pancreas (HP:0002894)2.29224075
77Agnosia (HP:0010524)2.28149769
78Premature ovarian failure (HP:0008209)2.26380374
79IgM deficiency (HP:0002850)2.26312905
80Abnormality of the labia minora (HP:0012880)2.25795649
81Macrocytic anemia (HP:0001972)2.25517881
82Attenuation of retinal blood vessels (HP:0007843)2.25517537
83Testicular atrophy (HP:0000029)2.23644014
84Small intestinal stenosis (HP:0012848)2.23141864
85Duodenal stenosis (HP:0100867)2.23141864
86Absent radius (HP:0003974)2.22705037
87Impulsivity (HP:0100710)2.21399310
88Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.19694815
89Abolished electroretinogram (ERG) (HP:0000550)2.18693028
90Medulloblastoma (HP:0002885)2.18002123
91Supernumerary spleens (HP:0009799)2.17417873
92Trismus (HP:0000211)2.16950192
93Basal cell carcinoma (HP:0002671)2.16823401
94Exercise intolerance (HP:0003546)2.15510402
95Squamous cell carcinoma (HP:0002860)2.15434916
96Progressive microcephaly (HP:0000253)2.15261085
97Poikiloderma (HP:0001029)2.14382227
98Petechiae (HP:0000967)2.14099137
99Overlapping toe (HP:0001845)2.12638606
100Abnormal trabecular bone morphology (HP:0100671)2.11948092
101Cellular immunodeficiency (HP:0005374)2.11714820
102Abnormal rod and cone electroretinograms (HP:0008323)2.10973379
103Poor head control (HP:0002421)2.10526942
104Pendular nystagmus (HP:0012043)2.10299448
105Tracheoesophageal fistula (HP:0002575)2.10048305
106Abnormality of urine glucose concentration (HP:0011016)2.09893477
107Glycosuria (HP:0003076)2.09893477
108True hermaphroditism (HP:0010459)2.09754261
109Atrophy/Degeneration involving motor neurons (HP:0007373)2.08971470
110Progressive muscle weakness (HP:0003323)2.08626967
111Hyperglycinemia (HP:0002154)2.07823882
112Secondary amenorrhea (HP:0000869)2.07594233
113Tongue fasciculations (HP:0001308)2.06763782
114Large for gestational age (HP:0001520)2.06198246
115Absent forearm bone (HP:0003953)2.05413805
116Aplasia involving forearm bones (HP:0009822)2.05413805
117Atresia of the external auditory canal (HP:0000413)2.05381956
118Broad alveolar ridges (HP:0000187)2.05164093
119Lymphoma (HP:0002665)2.04620433
120Pancreatic fibrosis (HP:0100732)2.04485089
121Abnormal number of incisors (HP:0011064)2.03058185
122Sloping forehead (HP:0000340)2.02210549
123Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.02089789
124Abnormal protein N-linked glycosylation (HP:0012347)2.02089789
125Abnormal protein glycosylation (HP:0012346)2.02089789
126Abnormal glycosylation (HP:0012345)2.02089789
127Nephroblastoma (Wilms tumor) (HP:0002667)2.02002295
128Ectopic kidney (HP:0000086)2.01705145
129Pancytopenia (HP:0001876)2.00120248
130Abnormality of renal resorption (HP:0011038)1.99231162
131Abnormal lung lobation (HP:0002101)1.98130476
132Leukodystrophy (HP:0002415)1.97299261
133Increased serum lactate (HP:0002151)1.97180150
134Ketoacidosis (HP:0001993)1.96155293
135Unsteady gait (HP:0002317)1.95821583
136Type I transferrin isoform profile (HP:0003642)1.95716774
137Hypoplasia of the capital femoral epiphysis (HP:0003090)1.94934726
138Nephronophthisis (HP:0000090)1.94018486
1393-Methylglutaconic aciduria (HP:0003535)1.93692995
140Inability to walk (HP:0002540)1.93523383
141Abnormality of DNA repair (HP:0003254)1.92340264
142Bile duct proliferation (HP:0001408)1.92177206
143Abnormal biliary tract physiology (HP:0012439)1.92177206
144Chronic mucocutaneous candidiasis (HP:0002728)1.92036562
145Recurrent cutaneous fungal infections (HP:0011370)1.92036562
146Abnormality of T cell physiology (HP:0011840)1.91766809
147Abnormality of the vitamin B12 metabolism (HP:0004341)1.90941925
148Cutaneous melanoma (HP:0012056)1.90882418
149Optic nerve coloboma (HP:0000588)1.90775463
150Medial flaring of the eyebrow (HP:0010747)1.90389448
151Neutropenia (HP:0001875)1.89424521
152Abnormality of vitamin B metabolism (HP:0004340)1.88536110
153Microvesicular hepatic steatosis (HP:0001414)1.87781018
154Opisthotonus (HP:0002179)1.87133309
155Aplasia/Hypoplasia of the sternum (HP:0006714)1.86900458
156Abnormality of pyrimidine metabolism (HP:0004353)1.86836655
157CNS demyelination (HP:0007305)1.86611495
158Abnormality of the fetal cardiovascular system (HP:0010948)1.85142160
159Abnormal umbilical cord blood vessels (HP:0011403)1.85142160
160Single umbilical artery (HP:0001195)1.85142160
161Reduced antithrombin III activity (HP:0001976)1.84938563
162Rhabdomyosarcoma (HP:0002859)1.83739020
163CNS hypomyelination (HP:0003429)1.83458618
164Elevated erythrocyte sedimentation rate (HP:0003565)1.83303987
165Breech presentation (HP:0001623)1.83243363
166Progressive inability to walk (HP:0002505)1.83001068
167Rib fusion (HP:0000902)1.82668698
168Horseshoe kidney (HP:0000085)1.82621787
169Delayed CNS myelination (HP:0002188)1.81995262
170Respiratory difficulties (HP:0002880)1.81374287
171Severe combined immunodeficiency (HP:0004430)1.81335614
172Embryonal renal neoplasm (HP:0011794)1.80824783
173Abnormality of serum amino acid levels (HP:0003112)1.80198784
174Nausea (HP:0002018)1.80117750
175Renal cortical cysts (HP:0000803)1.79929950
176Decreased central vision (HP:0007663)1.78845693
177Congenital, generalized hypertrichosis (HP:0004540)1.76849572
178Metabolic acidosis (HP:0001942)1.76710430
179Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.75915008
180Abnormality of alanine metabolism (HP:0010916)1.75915008
181Hyperalaninemia (HP:0003348)1.75915008
182Abnormality of the renal cortex (HP:0011035)1.75504495
183Absent rod-and cone-mediated responses on ERG (HP:0007688)1.72241009
184Bony spicule pigmentary retinopathy (HP:0007737)1.68691236
185Abnormality of aspartate family amino acid metabolism (HP:0010899)1.67057877
186Constricted visual fields (HP:0001133)1.66712185
187Retinal dysplasia (HP:0007973)1.64790697
188Chronic hepatic failure (HP:0100626)1.64419604

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.82034770
2MAP4K23.60025867
3WEE13.54082649
4CDC73.38393116
5VRK23.18976747
6BCKDK2.93089418
7NEK22.69582651
8EIF2AK12.61589324
9TESK22.51486183
10PLK42.47621813
11NME22.44678075
12TRIM282.43077736
13SRPK12.39160439
14PIM22.37411840
15NUAK12.32746954
16STK162.28897458
17FRK2.20046701
18TSSK62.08500635
19PLK12.04313770
20EIF2AK31.98748930
21CDK71.95917144
22NEK11.94924533
23VRK11.85863933
24TTK1.84872959
25DYRK31.82954084
26ATR1.82651978
27BRSK21.73593109
28WNK31.71690356
29BRAF1.56441845
30CDK81.55831564
31AURKB1.52560241
32ACVR1B1.51180102
33ARAF1.51174609
34MAP2K71.49462786
35TAOK31.48050628
36MAP2K61.46833767
37NME11.42332834
38MAPK131.40781085
39CHEK21.39554104
40OXSR11.38593409
41BMPR1B1.38538235
42RPS6KB21.37841409
43ZAK1.36254157
44MAP3K111.33927445
45MAP4K11.31884188
46PLK31.31365000
47RPS6KA41.27343435
48MKNK11.26850680
49TLK11.26592476
50CSNK1G31.26350803
51INSRR1.25846947
52BRSK11.25575626
53CCNB11.25092934
54AURKA1.18250502
55PASK1.17241027
56MAP3K81.14307284
57MAP3K121.14085920
58MAP3K41.13716563
59EPHA21.12445031
60MAP3K61.12354474
61PIK3CG1.12031465
62CSNK1G21.11743965
63PDK21.10091237
64TEC1.08878817
65TESK11.08616299
66MST41.08410805
67CHEK11.08347911
68CSNK1A1L1.06954971
69PIM11.02523643
70STK101.00650463
71DAPK21.00512734
72CSNK1G10.97549339
73SCYL20.94172327
74CDK40.93394570
75CDK190.92688494
76DYRK20.90170493
77PRKCI0.88679636
78STK40.88352378
79TAOK20.84122763
80CDK20.80541073
81KDR0.77439905
82RAF10.77139621
83TAF10.76895305
84CSNK2A10.76585013
85GRK60.75871314
86PAK40.75099147
87GRK70.74689070
88DAPK10.74299991
89CSNK2A20.73441949
90TNK20.72160923
91TIE10.71986303
92MAP3K100.71760138
93WNK40.66729794
94GRK50.66278791
95ATM0.65717450
96PRKCQ0.65639230
97ILK0.64820486
98MKNK20.63915452
99PAK10.63722965
100CDK120.63464406
101MAPKAPK30.63207115
102CSF1R0.62964352
103BMPR20.62633392
104YES10.62089477
105SIK30.61772686
106FLT30.60429814
107ADRBK10.59587115
108ERBB30.59091094
109SYK0.58517672
110BTK0.58481484
111ADRBK20.57348268
112EIF2AK20.54293311
113PRKCG0.53593712
114MARK10.52061574
115RPS6KA50.52050388
116CDK10.51028385
117LYN0.50986256
118PHKG20.50400273
119PHKG10.50400273
120AKT30.48659882
121DAPK30.47823774
122RPS6KA60.47540819
123STK38L0.46550205
124KIT0.46031606
125RPS6KC10.46006412
126RPS6KL10.46006412
127TAOK10.44679849
128ZAP700.44422251
129JAK30.43866812
130PINK10.43522288
131TGFBR10.43229378
132TXK0.43229228
133CSNK1A10.43009662
134LRRK20.42708676
135PRKCE0.42631062
136MATK0.41676684
137STK390.41525124
138ITK0.41304077
139LIMK10.41124751
140BCR0.40862532
141STK240.40748905
142GRK10.39329296
143MAPKAPK50.39070847
144CHUK0.38869215
145IKBKB0.38257045
146CAMKK20.37825548
147ALK0.37524321
148LCK0.36524327
149TBK10.35223216
150PBK0.35212079
151IKBKE0.35188322
152MAP2K40.34053736
153IRAK40.33775629
154EEF2K0.31599438

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.91979425
2Mismatch repair_Homo sapiens_hsa034304.15201142
3Proteasome_Homo sapiens_hsa030503.78138719
4RNA polymerase_Homo sapiens_hsa030203.67360548
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.52453914
6Ribosome_Homo sapiens_hsa030103.51706228
7Base excision repair_Homo sapiens_hsa034103.33205451
8Spliceosome_Homo sapiens_hsa030403.27369892
9Homologous recombination_Homo sapiens_hsa034403.15508342
10RNA transport_Homo sapiens_hsa030133.07536309
11Pyrimidine metabolism_Homo sapiens_hsa002402.80314407
12Nucleotide excision repair_Homo sapiens_hsa034202.73506237
13Cell cycle_Homo sapiens_hsa041102.64180950
14One carbon pool by folate_Homo sapiens_hsa006702.27593800
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.26248263
16Fanconi anemia pathway_Homo sapiens_hsa034602.15203030
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.07238829
18RNA degradation_Homo sapiens_hsa030181.96714668
19Caffeine metabolism_Homo sapiens_hsa002321.90478109
20Basal transcription factors_Homo sapiens_hsa030221.88646243
21Non-homologous end-joining_Homo sapiens_hsa034501.79281919
22Graft-versus-host disease_Homo sapiens_hsa053321.67880545
23mRNA surveillance pathway_Homo sapiens_hsa030151.66879334
24p53 signaling pathway_Homo sapiens_hsa041151.63357628
25Asthma_Homo sapiens_hsa053101.61587551
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.59018967
27Butanoate metabolism_Homo sapiens_hsa006501.56101707
28Purine metabolism_Homo sapiens_hsa002301.47295685
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.38659796
30Fatty acid elongation_Homo sapiens_hsa000621.38385199
31Peroxisome_Homo sapiens_hsa041461.38345393
32Type I diabetes mellitus_Homo sapiens_hsa049401.37839014
33Autoimmune thyroid disease_Homo sapiens_hsa053201.33706242
34Epstein-Barr virus infection_Homo sapiens_hsa051691.31150036
35Propanoate metabolism_Homo sapiens_hsa006401.28215883
36Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.25374665
37Phototransduction_Homo sapiens_hsa047441.24868917
38Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.13658661
39Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.13382561
40alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.13017250
41SNARE interactions in vesicular transport_Homo sapiens_hsa041301.11259972
42Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.06090611
43Folate biosynthesis_Homo sapiens_hsa007901.05727834
44Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.04385947
45Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.02687212
46Herpes simplex infection_Homo sapiens_hsa051680.97010160
47Antigen processing and presentation_Homo sapiens_hsa046120.96927754
48Tryptophan metabolism_Homo sapiens_hsa003800.94825515
49Linoleic acid metabolism_Homo sapiens_hsa005910.92878980
50Chemical carcinogenesis_Homo sapiens_hsa052040.92325887
51Collecting duct acid secretion_Homo sapiens_hsa049660.91241626
52Cyanoamino acid metabolism_Homo sapiens_hsa004600.88356717
53Cysteine and methionine metabolism_Homo sapiens_hsa002700.88108093
54Primary immunodeficiency_Homo sapiens_hsa053400.87927602
55Cardiac muscle contraction_Homo sapiens_hsa042600.87335088
56Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.87311810
57Rheumatoid arthritis_Homo sapiens_hsa053230.85437648
58Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.85353181
59Huntingtons disease_Homo sapiens_hsa050160.85054444
60Maturity onset diabetes of the young_Homo sapiens_hsa049500.84800150
61Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.84769644
62Protein export_Homo sapiens_hsa030600.80522973
63Sulfur relay system_Homo sapiens_hsa041220.79469438
64Thyroid cancer_Homo sapiens_hsa052160.78699357
65Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.76012337
66Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.75476092
67Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.74901381
68Parkinsons disease_Homo sapiens_hsa050120.74589618
69Ether lipid metabolism_Homo sapiens_hsa005650.73064924
70Pentose phosphate pathway_Homo sapiens_hsa000300.72918768
71Viral carcinogenesis_Homo sapiens_hsa052030.70907950
72Fructose and mannose metabolism_Homo sapiens_hsa000510.69848741
73Biosynthesis of amino acids_Homo sapiens_hsa012300.68966350
74Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.68776706
75Oocyte meiosis_Homo sapiens_hsa041140.66040586
76Drug metabolism - other enzymes_Homo sapiens_hsa009830.64648660
77Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.64091315
78HTLV-I infection_Homo sapiens_hsa051660.60098283
79Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.59095476
80Primary bile acid biosynthesis_Homo sapiens_hsa001200.58973749
81Apoptosis_Homo sapiens_hsa042100.57794452
82Regulation of autophagy_Homo sapiens_hsa041400.56527775
83Oxidative phosphorylation_Homo sapiens_hsa001900.56364086
84Fatty acid degradation_Homo sapiens_hsa000710.56202046
85Systemic lupus erythematosus_Homo sapiens_hsa053220.54953806
86NOD-like receptor signaling pathway_Homo sapiens_hsa046210.54338520
872-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.54337999
88Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.52422994
89Olfactory transduction_Homo sapiens_hsa047400.52279974
90Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.51530912
91Pyruvate metabolism_Homo sapiens_hsa006200.51473145
92Nitrogen metabolism_Homo sapiens_hsa009100.50645140
93Intestinal immune network for IgA production_Homo sapiens_hsa046720.49671620
94Taste transduction_Homo sapiens_hsa047420.47860129
95Vitamin B6 metabolism_Homo sapiens_hsa007500.46614623
96Acute myeloid leukemia_Homo sapiens_hsa052210.46250059
97Glutathione metabolism_Homo sapiens_hsa004800.44729603
98Colorectal cancer_Homo sapiens_hsa052100.44694169
99Measles_Homo sapiens_hsa051620.44542988
100Shigellosis_Homo sapiens_hsa051310.42899926
101Fatty acid metabolism_Homo sapiens_hsa012120.42453186
102Vitamin digestion and absorption_Homo sapiens_hsa049770.42317015
103beta-Alanine metabolism_Homo sapiens_hsa004100.41467626
104Galactose metabolism_Homo sapiens_hsa000520.41208756
105Nicotine addiction_Homo sapiens_hsa050330.40212140
106Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.40054437
107Small cell lung cancer_Homo sapiens_hsa052220.39757325
108RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.39003673
109Legionellosis_Homo sapiens_hsa051340.36991342
110Retinol metabolism_Homo sapiens_hsa008300.36101973
111Sulfur metabolism_Homo sapiens_hsa009200.35511021
112Steroid hormone biosynthesis_Homo sapiens_hsa001400.33847771
113Bladder cancer_Homo sapiens_hsa052190.33181065
114Hepatitis B_Homo sapiens_hsa051610.33038183
115Transcriptional misregulation in cancer_Homo sapiens_hsa052020.32312945
116N-Glycan biosynthesis_Homo sapiens_hsa005100.31650517
117Selenocompound metabolism_Homo sapiens_hsa004500.31122116
118Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.29898349
119NF-kappa B signaling pathway_Homo sapiens_hsa040640.29686786
120Metabolic pathways_Homo sapiens_hsa011000.28102889
121Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.27823436
122Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.27726824
123Carbon metabolism_Homo sapiens_hsa012000.25297237
124Notch signaling pathway_Homo sapiens_hsa043300.23962473
125Chronic myeloid leukemia_Homo sapiens_hsa052200.23147232
126Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.22662639
127MicroRNAs in cancer_Homo sapiens_hsa052060.21996494
128Influenza A_Homo sapiens_hsa051640.21815342
129Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.21739486
130Arachidonic acid metabolism_Homo sapiens_hsa005900.21637949
131Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.20974715
132HIF-1 signaling pathway_Homo sapiens_hsa040660.19066422
133Pathways in cancer_Homo sapiens_hsa052000.17911713
134Alzheimers disease_Homo sapiens_hsa050100.17394215
135Hippo signaling pathway_Homo sapiens_hsa043900.17276747
136Allograft rejection_Homo sapiens_hsa053300.15500918
137mTOR signaling pathway_Homo sapiens_hsa041500.15411362
138Arginine and proline metabolism_Homo sapiens_hsa003300.15340641
139Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.14978678
140Viral myocarditis_Homo sapiens_hsa054160.13195727
141Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.12274485
142Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.12199795
143Glycosaminoglycan degradation_Homo sapiens_hsa005310.11922590
144Alcoholism_Homo sapiens_hsa050340.11695021
145Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.11081415
146Non-small cell lung cancer_Homo sapiens_hsa052230.10398221
147Hematopoietic cell lineage_Homo sapiens_hsa046400.10290288
148Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.09975975
149Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.07672310

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