DNAJC19

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is thought to be part of a complex involved in the ATP-dependent transport of transit peptide-containing proteins from the inner cell membrane to the mitochondrial matrix. Defects in this gene are a cause of 3-methylglutaconic aciduria type 5 (MGA5), also known as dilated cardiomyopathy with ataxia (DCMA). Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1, 2, 6, 10, 14 and 19. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.20822386
2mitochondrial electron transport, NADH to ubiquinone (GO:0006120)6.08604096
3energy coupled proton transport, down electrochemical gradient (GO:0015985)5.91467786
4ATP synthesis coupled proton transport (GO:0015986)5.91467786
5respiratory electron transport chain (GO:0022904)5.46713134
6electron transport chain (GO:0022900)5.30676138
7ribosomal small subunit assembly (GO:0000028)5.13628296
8mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.88551962
9mitochondrial respiratory chain complex I assembly (GO:0032981)4.88551962
10NADH dehydrogenase complex assembly (GO:0010257)4.88551962
11proteasome assembly (GO:0043248)4.81613471
12ribosomal small subunit biogenesis (GO:0042274)4.70897789
13protein complex biogenesis (GO:0070271)4.69995229
14DNA deamination (GO:0045006)4.65877285
15viral transcription (GO:0019083)4.59642036
16translational termination (GO:0006415)4.46474638
17cotranslational protein targeting to membrane (GO:0006613)4.42190716
18SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.39647045
19mitochondrial respiratory chain complex assembly (GO:0033108)4.39630126
20protein targeting to ER (GO:0045047)4.34828727
21chaperone-mediated protein transport (GO:0072321)4.24599745
22protein localization to endoplasmic reticulum (GO:0070972)4.21301827
23establishment of protein localization to endoplasmic reticulum (GO:0072599)4.13550527
24transcription elongation from RNA polymerase III promoter (GO:0006385)4.09380892
25termination of RNA polymerase III transcription (GO:0006386)4.09380892
26L-methionine biosynthetic process from methylthioadenosine (GO:0019509)4.08126983
27rRNA modification (GO:0000154)4.02493621
28regulation of mitochondrial translation (GO:0070129)3.96318973
29respiratory chain complex IV assembly (GO:0008535)3.94418012
30chromatin remodeling at centromere (GO:0031055)3.87142771
31protein neddylation (GO:0045116)3.85766958
32maturation of SSU-rRNA (GO:0030490)3.85269895
33central nervous system myelination (GO:0022010)3.82556767
34axon ensheathment in central nervous system (GO:0032291)3.82556767
35CENP-A containing nucleosome assembly (GO:0034080)3.81441309
36translational elongation (GO:0006414)3.77943744
37oxidative phosphorylation (GO:0006119)3.72689445
38ribosomal large subunit biogenesis (GO:0042273)3.68889275
39translation (GO:0006412)3.68509243
40L-methionine salvage (GO:0071267)3.62686964
41L-methionine biosynthetic process (GO:0071265)3.62686964
42amino acid salvage (GO:0043102)3.62686964
43deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.57140605
44viral life cycle (GO:0019058)3.54118502
45GTP biosynthetic process (GO:0006183)3.50032763
46establishment of protein localization to mitochondrial membrane (GO:0090151)3.47978258
47signal peptide processing (GO:0006465)3.46339263
48cytochrome complex assembly (GO:0017004)3.45526263
49cellular protein complex disassembly (GO:0043624)3.44286703
50aldehyde catabolic process (GO:0046185)3.44109996
51RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.37471732
52tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.37471732
53spliceosomal snRNP assembly (GO:0000387)3.37047089
54* protein targeting to mitochondrion (GO:0006626)3.37025003
55DNA damage response, detection of DNA damage (GO:0042769)3.36143891
56regulation of cellular amino acid metabolic process (GO:0006521)3.33564776
57rRNA methylation (GO:0031167)3.31320549
58water-soluble vitamin biosynthetic process (GO:0042364)3.29005546
59translational initiation (GO:0006413)3.25041859
60protein complex disassembly (GO:0043241)3.22361181
61* establishment of protein localization to mitochondrion (GO:0072655)3.22046209
62negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.21667962
63anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.21281631
64GPI anchor biosynthetic process (GO:0006506)3.20169017
65metallo-sulfur cluster assembly (GO:0031163)3.19206800
66iron-sulfur cluster assembly (GO:0016226)3.19206800
67peptidyl-histidine modification (GO:0018202)3.18291696
68cellular component biogenesis (GO:0044085)3.17571735
69fatty acid elongation (GO:0030497)3.16284075
707-methylguanosine mRNA capping (GO:0006370)3.15327717
71macromolecular complex disassembly (GO:0032984)3.15177557
72aerobic respiration (GO:0009060)3.14611890
73RNA capping (GO:0036260)3.12814288
747-methylguanosine RNA capping (GO:0009452)3.12814288
75ribonucleoside triphosphate biosynthetic process (GO:0009201)3.12247345
76nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.11284803
77histone exchange (GO:0043486)3.09695452
78rRNA processing (GO:0006364)3.08637215
79nuclear-transcribed mRNA catabolic process (GO:0000956)3.08516143
80proton transport (GO:0015992)3.07697926
81purine nucleoside triphosphate biosynthetic process (GO:0009145)3.06920031
82antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.06246867
83purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.05560294
84ubiquinone biosynthetic process (GO:0006744)3.05065973
85quinone biosynthetic process (GO:1901663)3.05065973
86protein targeting to membrane (GO:0006612)3.04952433
87histone mRNA metabolic process (GO:0008334)3.04689184
88intracellular protein transmembrane import (GO:0044743)3.04612400
89* mitochondrial transport (GO:0006839)3.00521521
90organelle disassembly (GO:1903008)3.00361890
91hydrogen transport (GO:0006818)3.00356022
92DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.98620018
93nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.98276869
94protein-cofactor linkage (GO:0018065)2.98175400
95rRNA metabolic process (GO:0016072)2.97252253
96negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.96714987
97negative regulation of ligase activity (GO:0051352)2.96714987
98signal transduction involved in cell cycle checkpoint (GO:0072395)2.96276718
99exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.94458080
100protein deneddylation (GO:0000338)2.93998794
101* protein localization to mitochondrion (GO:0070585)2.93770134
102signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.93721367
103intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.93721367
104establishment of integrated proviral latency (GO:0075713)2.93487119
105positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.93312619
106ATP biosynthetic process (GO:0006754)2.92853875
107signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.92662520
108signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.92662520
109signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.92662520
110nucleoside triphosphate biosynthetic process (GO:0009142)2.91950338
111purine nucleobase biosynthetic process (GO:0009113)2.90244522
112UTP biosynthetic process (GO:0006228)2.89293251
113pseudouridine synthesis (GO:0001522)2.89260598
114mRNA catabolic process (GO:0006402)2.89061629
115cullin deneddylation (GO:0010388)2.88622409
116inner mitochondrial membrane organization (GO:0007007)2.88297096
117hydrogen ion transmembrane transport (GO:1902600)2.87768219
118positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.87345936
119purine nucleoside monophosphate biosynthetic process (GO:0009127)2.87327621
120deoxyribose phosphate biosynthetic process (GO:0046385)2.86011078
1212-deoxyribonucleotide biosynthetic process (GO:0009265)2.86011078
122ribonucleoprotein complex biogenesis (GO:0022613)2.85415039
123antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.85217183
124deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.84214406
125guanosine-containing compound biosynthetic process (GO:1901070)2.79487303
126signal transduction involved in DNA integrity checkpoint (GO:0072401)2.78556014
127signal transduction involved in DNA damage checkpoint (GO:0072422)2.78556014
128ubiquinone metabolic process (GO:0006743)2.78525954
129transcription from RNA polymerase I promoter (GO:0006360)2.78190378
130regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.77765166
131transcription elongation from RNA polymerase I promoter (GO:0006362)2.76185304
132preassembly of GPI anchor in ER membrane (GO:0016254)2.76137658

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.07128207
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.81792113
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.29317366
4* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.99856666
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.99261327
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.76873570
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.65707092
8MYC_18555785_ChIP-Seq_MESCs_Mouse3.52771086
9CREB1_15753290_ChIP-ChIP_HEK293T_Human3.35086998
10CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.34779705
11* ETS1_20019798_ChIP-Seq_JURKAT_Human3.34309902
12* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.14816504
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.07098105
14CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.04775214
15ELF1_17652178_ChIP-ChIP_JURKAT_Human2.90135745
16EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.81153152
17MYC_18358816_ChIP-ChIP_MESCs_Mouse2.75293673
18SRF_21415370_ChIP-Seq_HL-1_Mouse2.73513194
19VDR_23849224_ChIP-Seq_CD4+_Human2.57169229
20PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.50964675
21MYC_19030024_ChIP-ChIP_MESCs_Mouse2.35641437
22E2F1_18555785_ChIP-Seq_MESCs_Mouse2.27128881
23DCP1A_22483619_ChIP-Seq_HELA_Human2.25194049
24THAP11_20581084_ChIP-Seq_MESCs_Mouse2.13019047
25FOXP3_21729870_ChIP-Seq_TREG_Human2.10680540
26ELK1_19687146_ChIP-ChIP_HELA_Human2.01071586
27* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.99538049
28CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.98248979
29E2F7_22180533_ChIP-Seq_HELA_Human1.96660825
30MYC_19079543_ChIP-ChIP_MESCs_Mouse1.95669902
31YY1_21170310_ChIP-Seq_MESCs_Mouse1.94973051
32XRN2_22483619_ChIP-Seq_HELA_Human1.93997855
33CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.89075758
34CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.83807023
35EGR1_23403033_ChIP-Seq_LIVER_Mouse1.83041067
36ZNF274_21170338_ChIP-Seq_K562_Hela1.78766340
37HOXB4_20404135_ChIP-ChIP_EML_Mouse1.77699609
38FUS_26573619_Chip-Seq_HEK293_Human1.73456200
39SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.71989697
40EWS_26573619_Chip-Seq_HEK293_Human1.69055829
41FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.66714401
42ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.66306387
43GABP_19822575_ChIP-Seq_HepG2_Human1.65276200
44ERG_20887958_ChIP-Seq_HPC-7_Mouse1.62946540
45TTF2_22483619_ChIP-Seq_HELA_Human1.62836203
46NELFA_20434984_ChIP-Seq_ESCs_Mouse1.59195831
47HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.56921729
48E2F4_17652178_ChIP-ChIP_JURKAT_Human1.51696868
49ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.48082260
50TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.46847067
51FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.38867336
52PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.38420941
53IRF1_19129219_ChIP-ChIP_H3396_Human1.38339479
54FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.34166322
55POU5F1_16153702_ChIP-ChIP_HESCs_Human1.33266390
56MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.33070776
57ELK1_22589737_ChIP-Seq_MCF10A_Human1.31151172
58IGF1R_20145208_ChIP-Seq_DFB_Human1.27467817
59* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.26750766
60POU3F2_20337985_ChIP-ChIP_501MEL_Human1.25816974
61BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.25251265
62* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.23114546
63TAF15_26573619_Chip-Seq_HEK293_Human1.20200378
64NANOG_16153702_ChIP-ChIP_HESCs_Human1.18199029
65SOX2_16153702_ChIP-ChIP_HESCs_Human1.16605355
66POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.16404334
67IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.16149674
68* MYC_18940864_ChIP-ChIP_HL60_Human1.15970763
69BP1_19119308_ChIP-ChIP_Hs578T_Human1.15942160
70YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.12738817
71POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.10573786
72SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.10313623
73TP53_22573176_ChIP-Seq_HFKS_Human1.09584183
74E2F1_21310950_ChIP-Seq_MCF-7_Human1.09356882
75P300_19829295_ChIP-Seq_ESCs_Human1.04688757
76MYCN_18555785_ChIP-Seq_MESCs_Mouse1.03628330
77MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.03276331
78SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.02823190
79MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.02360643
80SOX2_18555785_ChIP-Seq_MESCs_Mouse1.00589393
81SALL1_21062744_ChIP-ChIP_HESCs_Human1.00364470
82SOX17_20123909_ChIP-Seq_XEN_Mouse1.00006866
83* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.99409247
84EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.99116456
85GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.98662751
86* PADI4_21655091_ChIP-ChIP_MCF-7_Human0.96848132
87CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.96496175
88ZFP57_27257070_Chip-Seq_ESCs_Mouse0.96199623
89NANOG_18555785_ChIP-Seq_MESCs_Mouse0.92663292
90CTBP1_25329375_ChIP-Seq_LNCAP_Human0.92638713
91CTBP2_25329375_ChIP-Seq_LNCAP_Human0.90507565
92PCGF2_27294783_Chip-Seq_ESCs_Mouse0.89643387
93PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.87186252
94TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.86645659
95VDR_22108803_ChIP-Seq_LS180_Human0.86481291
96KAP1_22055183_ChIP-Seq_ESCs_Mouse0.85998228
97CTCF_18555785_ChIP-Seq_MESCs_Mouse0.85695428
98STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.85312526
99NOTCH1_21737748_ChIP-Seq_TLL_Human0.83806724
100GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.83251833
101NANOG_19829295_ChIP-Seq_ESCs_Human0.83170357
102SOX2_19829295_ChIP-Seq_ESCs_Human0.83170357
103FLI1_27457419_Chip-Seq_LIVER_Mouse0.82168661
104NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.81630228
105GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.81256037
106PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.80708382
107FOXA1_27270436_Chip-Seq_PROSTATE_Human0.78891006
108FOXA1_25329375_ChIP-Seq_VCAP_Human0.78891006
109* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.78424328
110FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.77564571
111HTT_18923047_ChIP-ChIP_STHdh_Human0.76677053
112KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.76097935
113LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.75138845
114GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.74674355
115BMI1_23680149_ChIP-Seq_NPCS_Mouse0.74138023
116* PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.73904757
117ER_23166858_ChIP-Seq_MCF-7_Human0.73396428
118TP63_19390658_ChIP-ChIP_HaCaT_Human0.73391355
119ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.73145683
120SPI1_23547873_ChIP-Seq_NB4_Human0.73022164
121STAT1_20625510_ChIP-Seq_HELA_Human0.71721200
122HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.70698818
123EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.68362509
124RXR_22158963_ChIP-Seq_LIVER_Mouse0.68105949
125KDM5A_27292631_Chip-Seq_BREAST_Human0.66567105
126E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.65323589
127* AR_20517297_ChIP-Seq_VCAP_Human0.65188135
128TBX5_21415370_ChIP-Seq_HL-1_Mouse0.64764996
129IRF8_22096565_ChIP-ChIP_GC-B_Human0.64205037
130RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.64181041
131SOX2_18692474_ChIP-Seq_MEFs_Mouse0.64092514

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis4.42227686
2MP0009379_abnormal_foot_pigmentation3.88301714
3MP0003186_abnormal_redox_activity3.52245711
4MP0003195_calcinosis3.12237270
5MP0002837_dystrophic_cardiac_calcinosis3.00064166
6MP0006036_abnormal_mitochondrial_physio2.96614860
7MP0003136_yellow_coat_color2.90529280
8MP0001529_abnormal_vocalization2.68279560
9MP0002139_abnormal_hepatobiliary_system2.54059032
10MP0004147_increased_porphyrin_level2.50035762
11MP0009697_abnormal_copulation2.47113897
12MP0006072_abnormal_retinal_apoptosis2.22603244
13MP0004381_abnormal_hair_follicle2.19419560
14MP0005085_abnormal_gallbladder_physiolo2.18760433
15MP0005360_urolithiasis2.17421191
16MP0005451_abnormal_body_composition2.15237679
17MP0004043_abnormal_pH_regulation2.12750959
18MP0002132_abnormal_respiratory_system2.07008686
19MP0001764_abnormal_homeostasis2.04153353
20MP0003880_abnormal_central_pattern1.99668697
21MP0006035_abnormal_mitochondrial_morpho1.98514796
22MP0008877_abnormal_DNA_methylation1.97662324
23MP0004142_abnormal_muscle_tone1.93383404
24MP0008875_abnormal_xenobiotic_pharmacok1.88702668
25MP0003693_abnormal_embryo_hatching1.88015994
26MP0003724_increased_susceptibility_to1.87346536
27MP0005332_abnormal_amino_acid1.87181209
28MP0001905_abnormal_dopamine_level1.86506898
29MP0000920_abnormal_myelination1.83987996
30MP0000372_irregular_coat_pigmentation1.83151662
31MP0003656_abnormal_erythrocyte_physiolo1.83005027
32MP0008789_abnormal_olfactory_epithelium1.81858913
33MP0003718_maternal_effect1.81314215
34MP0005408_hypopigmentation1.80730781
35MP0004145_abnormal_muscle_electrophysio1.79610992
36MP0001293_anophthalmia1.75505654
37MP0005075_abnormal_melanosome_morpholog1.71021802
38MP0005365_abnormal_bile_salt1.66956405
39MP0001986_abnormal_taste_sensitivity1.66951030
40MP0003950_abnormal_plasma_membrane1.66041413
41MP0002102_abnormal_ear_morphology1.62596911
42MP0002638_abnormal_pupillary_reflex1.61392038
43MP0004957_abnormal_blastocyst_morpholog1.56580996
44MP0008995_early_reproductive_senescence1.51229434
45MP0003890_abnormal_embryonic-extraembry1.47806002
46MP0005171_absent_coat_pigmentation1.47144602
47MP0003567_abnormal_fetal_cardiomyocyte1.46026732
48MP0005636_abnormal_mineral_homeostasis1.45705989
49MP0005084_abnormal_gallbladder_morpholo1.44112691
50MP0001984_abnormal_olfaction1.43988968
51MP0005083_abnormal_biliary_tract1.41984375
52MP0003941_abnormal_skin_development1.41111247
53MP0003111_abnormal_nucleus_morphology1.39227191
54MP0000631_abnormal_neuroendocrine_gland1.38071928
55MP0008058_abnormal_DNA_repair1.36207769
56MP0008932_abnormal_embryonic_tissue1.36090115
57MP0005646_abnormal_pituitary_gland1.33876120
58MP0002234_abnormal_pharynx_morphology1.33572775
59MP0009785_altered_susceptibility_to1.32200058
60MP0002653_abnormal_ependyma_morphology1.30476758
61MP0005379_endocrine/exocrine_gland_phen1.29238526
62MP0002148_abnormal_hypersensitivity_rea1.28939436
63MP0004133_heterotaxia1.28373763
64MP0006292_abnormal_olfactory_placode1.27647391
65MP0008057_abnormal_DNA_replication1.27258928
66MP0005645_abnormal_hypothalamus_physiol1.26697988
67MP0010030_abnormal_orbit_morphology1.25975591
68MP0008007_abnormal_cellular_replicative1.24253721
69MP0003121_genomic_imprinting1.24122694
70MP0005394_taste/olfaction_phenotype1.22642336
71MP0005499_abnormal_olfactory_system1.22642336
72MP0002736_abnormal_nociception_after1.21733920
73MP0002160_abnormal_reproductive_system1.20783950
74MP0001666_abnormal_nutrient_absorption1.17874446
75MP0008872_abnormal_physiological_respon1.17487484
76MP0004215_abnormal_myocardial_fiber1.15251337
77MP0002163_abnormal_gland_morphology1.14160057
78MP0002876_abnormal_thyroid_physiology1.09061397
79MP0009333_abnormal_splenocyte_physiolog1.09010352
80MP0001485_abnormal_pinna_reflex1.08296180
81MP0005584_abnormal_enzyme/coenzyme_acti1.07163174
82MP0003937_abnormal_limbs/digits/tail_de1.06791709
83MP0009046_muscle_twitch1.06365543
84MP0003646_muscle_fatigue1.06047574
85MP0005409_darkened_coat_color1.05963850
86MP0005671_abnormal_response_to1.05886799
87MP0001661_extended_life_span1.05667649
88MP0002277_abnormal_respiratory_mucosa1.03876551
89MP0003137_abnormal_impulse_conducting1.02529314
90MP0010094_abnormal_chromosome_stability1.02072717
91MP0000049_abnormal_middle_ear1.00859312
92MP0003787_abnormal_imprinting1.00242706
93MP0002210_abnormal_sex_determination0.99512260
94MP0005266_abnormal_metabolism0.99252546
95MP0008469_abnormal_protein_level0.98383252
96MP0009643_abnormal_urine_homeostasis0.98381749
97MP0000749_muscle_degeneration0.97744749
98MP0002938_white_spotting0.97709280
99MP0002272_abnormal_nervous_system0.97366047
100MP0002751_abnormal_autonomic_nervous0.96456117
101MP0008260_abnormal_autophagy0.96391251
102MP0004019_abnormal_vitamin_homeostasis0.96230109
103MP0006082_CNS_inflammation0.92838378
104MP0009840_abnormal_foam_cell0.92456216
105MP0001968_abnormal_touch/_nociception0.92276900
106MP0000566_synostosis0.89591327
107MP0005025_abnormal_response_to0.88923551
108MP0001835_abnormal_antigen_presentation0.88741304
109MP0005319_abnormal_enzyme/_coenzyme0.88620158
110MP0005376_homeostasis/metabolism_phenot0.87505334
111MP0003938_abnormal_ear_development0.87092304
112MP0003315_abnormal_perineum_morphology0.86235922
113MP0000653_abnormal_sex_gland0.85732089
114MP0003077_abnormal_cell_cycle0.85539401
115MP0003011_delayed_dark_adaptation0.85308457
116MP0003123_paternal_imprinting0.85196309
117MP0001929_abnormal_gametogenesis0.84631538
118MP0001145_abnormal_male_reproductive0.84376785
119MP0003122_maternal_imprinting0.84132904
120MP0001286_abnormal_eye_development0.84092477
121MP0001853_heart_inflammation0.84071078
122MP0009745_abnormal_behavioral_response0.83833777
123MP0002095_abnormal_skin_pigmentation0.81906278
124MP0002233_abnormal_nose_morphology0.79472071
125MP0003690_abnormal_glial_cell0.78338818
126MP0005391_vision/eye_phenotype0.74950735
127MP0009764_decreased_sensitivity_to0.74885686
128MP0002332_abnormal_exercise_endurance0.74338103
129MP0003786_premature_aging0.73894354
130MP0003283_abnormal_digestive_organ0.73796059
131MP0009765_abnormal_xenobiotic_induced0.73582334
132MP0005000_abnormal_immune_tolerance0.70955132
133MP0003698_abnormal_male_reproductive0.70868020
134MP0005195_abnormal_posterior_eye0.70198676
135MP0002090_abnormal_vision0.69878461
136MP0009763_increased_sensitivity_to0.67209251
137MP0001542_abnormal_bone_strength0.65387459
138MP0002229_neurodegeneration0.64185142
139MP0002419_abnormal_innate_immunity0.63527758
140MP0005410_abnormal_fertilization0.63519508
141MP0002118_abnormal_lipid_homeostasis0.61118106
142MP0005551_abnormal_eye_electrophysiolog0.59890258
143MP0002723_abnormal_immune_serum0.58029586
144MP0003763_abnormal_thymus_physiology0.57898704
145MP0001188_hyperpigmentation0.57613627
146MP0005220_abnormal_exocrine_pancreas0.57588544
147MP0000358_abnormal_cell_content/0.57195573
148MP0008004_abnormal_stomach_pH0.55491806
149MP0001727_abnormal_embryo_implantation0.55478750
150MP0005253_abnormal_eye_physiology0.53296133
151MP0006276_abnormal_autonomic_nervous0.52230468
152MP0000613_abnormal_salivary_gland0.50878574
153MP0001663_abnormal_digestive_system0.50096373
154MP0005389_reproductive_system_phenotype0.49959495

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.87379229
2Abnormal mitochondria in muscle tissue (HP:0008316)5.35913978
3Mitochondrial inheritance (HP:0001427)5.32957972
4Acute encephalopathy (HP:0006846)5.20209667
5Hepatocellular necrosis (HP:0001404)4.89183704
6Progressive macrocephaly (HP:0004481)4.81578076
7Hepatic necrosis (HP:0002605)4.69947780
8Increased CSF lactate (HP:0002490)4.69638162
9Increased hepatocellular lipid droplets (HP:0006565)4.28811722
10Decreased activity of mitochondrial respiratory chain (HP:0008972)4.21012058
11Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.21012058
12Cerebral edema (HP:0002181)4.08794875
13Lipid accumulation in hepatocytes (HP:0006561)4.05117215
14Renal Fanconi syndrome (HP:0001994)3.88884990
15Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.79399592
16Abnormality of cells of the erythroid lineage (HP:0012130)3.75105749
17Abnormal number of erythroid precursors (HP:0012131)3.61394925
18Increased intramyocellular lipid droplets (HP:0012240)3.55585041
19Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.53940463
20Lactic acidosis (HP:0003128)3.46858287
21Increased serum lactate (HP:0002151)3.46490269
22Leukodystrophy (HP:0002415)3.44522775
23Reticulocytopenia (HP:0001896)3.40665760
24Respiratory failure (HP:0002878)3.39310062
25Abnormality of glycolysis (HP:0004366)3.38831820
26Increased serum pyruvate (HP:0003542)3.38831820
27Exercise intolerance (HP:0003546)3.21229641
28Parakeratosis (HP:0001036)3.19428607
29* 3-Methylglutaconic aciduria (HP:0003535)3.14800070
30Increased muscle lipid content (HP:0009058)3.13688128
31Abnormality of aromatic amino acid family metabolism (HP:0004338)3.09468878
32Colon cancer (HP:0003003)2.98700054
33Exertional dyspnea (HP:0002875)2.98438190
34Optic disc pallor (HP:0000543)2.95439910
35Cerebral hypomyelination (HP:0006808)2.95073729
36Macrocytic anemia (HP:0001972)2.90953757
37Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.76630021
38Lethargy (HP:0001254)2.75848528
39Glycosuria (HP:0003076)2.74931895
40Abnormality of urine glucose concentration (HP:0011016)2.74931895
41Abnormality of renal resorption (HP:0011038)2.72243471
42Pancreatic cysts (HP:0001737)2.71873805
43Aplasia/Hypoplasia of the sacrum (HP:0008517)2.69612368
44Congenital, generalized hypertrichosis (HP:0004540)2.60966149
45Respiratory difficulties (HP:0002880)2.59036972
46Abnormality of the labia minora (HP:0012880)2.57508828
47CNS demyelination (HP:0007305)2.57048885
48Generalized aminoaciduria (HP:0002909)2.53925396
49Pancreatic fibrosis (HP:0100732)2.50005037
50Type I transferrin isoform profile (HP:0003642)2.48207244
51Pallor (HP:0000980)2.41850246
52Methylmalonic aciduria (HP:0012120)2.36802559
53Abnormality of the heme biosynthetic pathway (HP:0010472)2.29757758
54Medial flaring of the eyebrow (HP:0010747)2.29074400
55True hermaphroditism (HP:0010459)2.28579220
56Hyperphosphaturia (HP:0003109)2.20887306
57Prolonged neonatal jaundice (HP:0006579)2.17308298
58Abnormality of midbrain morphology (HP:0002418)2.14467784
59Molar tooth sign on MRI (HP:0002419)2.14467784
60Methylmalonic acidemia (HP:0002912)2.12305720
61Congenital ichthyosiform erythroderma (HP:0007431)2.10987249
62* Dicarboxylic aciduria (HP:0003215)2.10100280
63* Abnormality of dicarboxylic acid metabolism (HP:0010995)2.10100280
64Abnormality of aspartate family amino acid metabolism (HP:0010899)2.06061981
65Aplasia/hypoplasia of the uterus (HP:0008684)2.04900337
66Reduced antithrombin III activity (HP:0001976)2.02676132
67Abnormality of fatty-acid metabolism (HP:0004359)2.01807976
68Nausea (HP:0002018)2.01434952
69Vomiting (HP:0002013)1.96258766
70Septo-optic dysplasia (HP:0100842)1.95230755
71Spastic paraparesis (HP:0002313)1.94837832
72Renal tubular dysfunction (HP:0000124)1.94832537
73Congenital primary aphakia (HP:0007707)1.93858032
74Pancytopenia (HP:0001876)1.93070595
75Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.92929492
76Abnormality of alanine metabolism (HP:0010916)1.92929492
77Hyperalaninemia (HP:0003348)1.92929492
78Hepatosplenomegaly (HP:0001433)1.90972161
79Proximal tubulopathy (HP:0000114)1.90468066
80CNS hypomyelination (HP:0003429)1.87916047
81Congenital stationary night blindness (HP:0007642)1.87750549
82Degeneration of anterior horn cells (HP:0002398)1.87600977
83Abnormality of the anterior horn cell (HP:0006802)1.87600977
84Nephronophthisis (HP:0000090)1.87485725
85Hyperglycinemia (HP:0002154)1.87342061
86Gait imbalance (HP:0002141)1.86878233
87Abnormality of vitamin B metabolism (HP:0004340)1.86852340
88Abnormal urine phosphate concentration (HP:0012599)1.86381731
89Oral leukoplakia (HP:0002745)1.85020904
90Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.84821302
91Abnormality of serum amino acid levels (HP:0003112)1.84802603
92Renal cortical cysts (HP:0000803)1.83175095
93Hyperglycinuria (HP:0003108)1.83054840
94Patchy hypopigmentation of hair (HP:0011365)1.82081338
95Abnormality of the vitamin B12 metabolism (HP:0004341)1.81602721
96Emotional lability (HP:0000712)1.81253256
97Aplastic anemia (HP:0001915)1.80640115
98Abnormal hemoglobin (HP:0011902)1.80396258
99Abnormal protein glycosylation (HP:0012346)1.80071246
100Abnormal glycosylation (HP:0012345)1.80071246
101Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.80071246
102Abnormal protein N-linked glycosylation (HP:0012347)1.80071246
103Nephrogenic diabetes insipidus (HP:0009806)1.79529740
104Poor head control (HP:0002421)1.77786262
105Triphalangeal thumb (HP:0001199)1.77744335
106Sclerocornea (HP:0000647)1.76472373
107Prolonged partial thromboplastin time (HP:0003645)1.76094944
108Pendular nystagmus (HP:0012043)1.75730552
109Hypoplasia of the uterus (HP:0000013)1.75610552
110Meckel diverticulum (HP:0002245)1.75536082
111X-linked dominant inheritance (HP:0001423)1.74885504
112Metabolic acidosis (HP:0001942)1.72256682
113Megaloblastic anemia (HP:0001889)1.72204974
114Abnormality of methionine metabolism (HP:0010901)1.69969017
115Abnormality of the ileum (HP:0001549)1.68589488
116Abnormal pupillary function (HP:0007686)1.68351795
117Intrahepatic cholestasis (HP:0001406)1.67320050
118Birth length less than 3rd percentile (HP:0003561)1.67052910
119Opisthotonus (HP:0002179)1.66705435
120Aplasia/Hypoplasia of the uvula (HP:0010293)1.66687246
121Hypoplasia of the pons (HP:0012110)1.66349150
122Abnormality of the pons (HP:0007361)1.66057615
123Abnormality of the axillary hair (HP:0100134)1.66052128
124Abnormality of secondary sexual hair (HP:0009888)1.66052128
125Absent thumb (HP:0009777)1.64606876
126Neuroendocrine neoplasm (HP:0100634)1.64532197
127Brushfield spots (HP:0001088)1.64388382
128Hyperammonemia (HP:0001987)1.64165938
129Abnormality of serine family amino acid metabolism (HP:0010894)1.63237640
130Abnormality of glycine metabolism (HP:0010895)1.63237640
131Absent septum pellucidum (HP:0001331)1.63006257
132Amniotic constriction ring (HP:0009775)1.62952629
133Abnormality of placental membranes (HP:0011409)1.62952629
134Delayed CNS myelination (HP:0002188)1.62178678
135Gliosis (HP:0002171)1.62138146

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.41234959
2STK164.15730695
3NME23.92718344
4PBK3.50931551
5EIF2AK12.98541509
6STK392.70189126
7BCKDK2.69188924
8BUB12.69180286
9VRK12.46917870
10TLK12.21144681
11NME12.19721607
12EIF2AK32.14539223
13MST42.10740914
14OXSR12.05706831
15MAP4K21.95009496
16WEE11.93605523
17NEK11.88933044
18SRPK11.80309148
19MUSK1.79830940
20TRIM281.65782852
21CDK191.60959427
22IRAK31.59527108
23BMPR1B1.54973289
24ARAF1.52708245
25PLK41.51466977
26MAPKAPK51.49510093
27PIM21.41036700
28TAF11.40280018
29ZAK1.32705390
30TESK21.27255832
31WNK41.25501978
32IRAK41.25456911
33TNIK1.25115664
34BCR1.22549947
35LIMK11.22196472
36FRK1.17220918
37ADRBK21.16508487
38MAP3K41.14641571
39DYRK21.10300701
40BRAF1.09956091
41MKNK11.08221050
42INSRR1.07403750
43RPS6KA51.06125438
44KDR1.06000896
45IRAK11.05756910
46PINK11.05163992
47TXK1.04730744
48CASK1.04181281
49IRAK21.02233101
50PASK1.01967184
51GRK71.00736730
52PKN10.99016814
53CSNK1G30.96525928
54BRSK20.95090709
55EIF2AK20.94058060
56CSNK1G20.93821939
57MAP2K70.93299146
58ABL20.91800050
59TEC0.90275725
60OBSCN0.89928974
61MYLK0.85048708
62DYRK30.84980825
63PHKG10.81449846
64PHKG20.81449846
65PLK20.81228068
66CCNB10.81176605
67NEK60.77897846
68CDK80.75041621
69BMPR20.74817354
70CSNK1G10.73548822
71MET0.73354581
72BLK0.72516092
73PDK20.70410079
74ERBB30.68533365
75ATR0.68356678
76CHEK20.68256850
77AURKA0.67316858
78MAPK150.66060678
79MAP3K140.65889978
80PIK3CG0.63877483
81GRK10.63770044
82CSNK2A10.62241548
83BRSK10.61840613
84PRKCG0.61626370
85IKBKB0.61352563
86CAMK2B0.61189239
87CAMK2G0.59396239
88MKNK20.56616001
89TGFBR10.56428288
90CAMK2D0.55481408
91CSNK2A20.55271918
92CSNK1A1L0.52705118
93MAP3K120.51424279
94STK40.51323945
95MAP2K60.51008027
96YES10.50886822
97AURKB0.50639972
98CDC70.50415648
99TSSK60.49522827
100EPHA40.48923356
101PLK10.48370737
102NEK20.48108557
103IKBKE0.47615771
104ATM0.46670782
105ACVR1B0.46566997
106DAPK10.46430798
107MAP3K110.45660081
108MAPK130.44073909
109RPS6KA40.43735627
110NLK0.43580866
111TYK20.42878338
112PRKCE0.41828385
113CSNK1E0.41461587
114CDK70.40334542
115DAPK30.40292303
116RPS6KB20.39480634
117LYN0.39183528
118TTK0.38990821
119MINK10.38378387
120NUAK10.38046206
121CSNK1A10.36227863
122STK38L0.35810269
123PAK30.34057116
124FLT30.33976431
125PRKACA0.32980051
126AKT30.32198122
127CAMK2A0.31095060
128EPHA20.30992633
129ADRBK10.30829655
130TIE10.30644819
131ILK0.30166964
132STK30.30148529
133WNK30.29785896
134PAK10.29021478
135PLK30.28690648
136CLK10.28367841
137BTK0.27521730
138STK240.26777842
139MAP4K10.26446431

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.13550747
2Ribosome_Homo sapiens_hsa030104.13173036
3Parkinsons disease_Homo sapiens_hsa050123.59808901
4Proteasome_Homo sapiens_hsa030503.34454548
5Protein export_Homo sapiens_hsa030603.32974626
6RNA polymerase_Homo sapiens_hsa030202.82632447
7Huntingtons disease_Homo sapiens_hsa050162.52974726
8Alzheimers disease_Homo sapiens_hsa050102.50071634
9Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.36799033
10Folate biosynthesis_Homo sapiens_hsa007902.24293257
11Fatty acid elongation_Homo sapiens_hsa000622.11398102
12DNA replication_Homo sapiens_hsa030302.01491791
13Pyrimidine metabolism_Homo sapiens_hsa002401.97653940
14Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.96311840
15Mismatch repair_Homo sapiens_hsa034301.78064931
16Homologous recombination_Homo sapiens_hsa034401.69599571
17Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.67705682
18Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.59388360
19Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.56648845
20Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.52153907
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.52096700
22Steroid biosynthesis_Homo sapiens_hsa001001.48672558
23Sulfur metabolism_Homo sapiens_hsa009201.47648250
24Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.44137472
25Nucleotide excision repair_Homo sapiens_hsa034201.38744777
26Peroxisome_Homo sapiens_hsa041461.38171411
27Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.34391933
28Spliceosome_Homo sapiens_hsa030401.32962455
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.31556084
30Propanoate metabolism_Homo sapiens_hsa006401.30559314
31Histidine metabolism_Homo sapiens_hsa003401.23867193
32Glutathione metabolism_Homo sapiens_hsa004801.23075873
33Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.19531765
34Basal transcription factors_Homo sapiens_hsa030221.18837137
35Sulfur relay system_Homo sapiens_hsa041221.13810644
36Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.11043435
37Cardiac muscle contraction_Homo sapiens_hsa042601.10423034
38Purine metabolism_Homo sapiens_hsa002301.09942547
39Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.06582202
40Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.04390149
41Metabolic pathways_Homo sapiens_hsa011001.02874848
42Base excision repair_Homo sapiens_hsa034101.02435773
43Non-homologous end-joining_Homo sapiens_hsa034501.02373815
44Phototransduction_Homo sapiens_hsa047440.99938001
45Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.99230872
46Arachidonic acid metabolism_Homo sapiens_hsa005900.99212469
47Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.98075639
48Pentose and glucuronate interconversions_Homo sapiens_hsa000400.96554494
49Arginine and proline metabolism_Homo sapiens_hsa003300.96175932
50Primary bile acid biosynthesis_Homo sapiens_hsa001200.94909167
51Linoleic acid metabolism_Homo sapiens_hsa005910.94639673
52Drug metabolism - other enzymes_Homo sapiens_hsa009830.94333353
53Pyruvate metabolism_Homo sapiens_hsa006200.93676215
54Chemical carcinogenesis_Homo sapiens_hsa052040.90361609
55SNARE interactions in vesicular transport_Homo sapiens_hsa041300.89159412
56One carbon pool by folate_Homo sapiens_hsa006700.88082178
57Cysteine and methionine metabolism_Homo sapiens_hsa002700.87499680
58RNA degradation_Homo sapiens_hsa030180.86012521
59Fanconi anemia pathway_Homo sapiens_hsa034600.85671089
60beta-Alanine metabolism_Homo sapiens_hsa004100.83742575
61Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.81371334
62Ether lipid metabolism_Homo sapiens_hsa005650.79960099
63Steroid hormone biosynthesis_Homo sapiens_hsa001400.79436912
64Butanoate metabolism_Homo sapiens_hsa006500.76364728
65Tyrosine metabolism_Homo sapiens_hsa003500.75520104
66alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.74433872
67Cyanoamino acid metabolism_Homo sapiens_hsa004600.74288155
68Fatty acid degradation_Homo sapiens_hsa000710.73870505
69Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.71588032
70Nitrogen metabolism_Homo sapiens_hsa009100.70048466
71Retinol metabolism_Homo sapiens_hsa008300.68468374
72Phenylalanine metabolism_Homo sapiens_hsa003600.68348815
73Cell cycle_Homo sapiens_hsa041100.67552157
74Maturity onset diabetes of the young_Homo sapiens_hsa049500.67280612
75Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.66890028
76Carbon metabolism_Homo sapiens_hsa012000.66332588
77Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.65442240
78Vitamin B6 metabolism_Homo sapiens_hsa007500.65189031
79RNA transport_Homo sapiens_hsa030130.63186104
80Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.60058318
81Pentose phosphate pathway_Homo sapiens_hsa000300.58261612
82Systemic lupus erythematosus_Homo sapiens_hsa053220.51095993
83Tryptophan metabolism_Homo sapiens_hsa003800.51060346
84Nicotine addiction_Homo sapiens_hsa050330.50998660
85Sphingolipid metabolism_Homo sapiens_hsa006000.50233853
86Fatty acid metabolism_Homo sapiens_hsa012120.50159661
87Selenocompound metabolism_Homo sapiens_hsa004500.48380077
88Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.43636340
89Regulation of autophagy_Homo sapiens_hsa041400.43351438
90Allograft rejection_Homo sapiens_hsa053300.42031200
91Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.42030538
92Vitamin digestion and absorption_Homo sapiens_hsa049770.41877405
93Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.41230461
94Graft-versus-host disease_Homo sapiens_hsa053320.39537207
95Oocyte meiosis_Homo sapiens_hsa041140.38931378
96Biosynthesis of amino acids_Homo sapiens_hsa012300.37449014
97Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.37276432
98Autoimmune thyroid disease_Homo sapiens_hsa053200.35995923
99Asthma_Homo sapiens_hsa053100.33963128
100Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.33395793
101mRNA surveillance pathway_Homo sapiens_hsa030150.32584998
102Caffeine metabolism_Homo sapiens_hsa002320.30365245
103p53 signaling pathway_Homo sapiens_hsa041150.30252285
104Collecting duct acid secretion_Homo sapiens_hsa049660.28406893
105Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.27295303
106Rheumatoid arthritis_Homo sapiens_hsa053230.24744107
107Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.24313447
108N-Glycan biosynthesis_Homo sapiens_hsa005100.23615199
109Starch and sucrose metabolism_Homo sapiens_hsa005000.23478697
110Vibrio cholerae infection_Homo sapiens_hsa051100.23440377
111Basal cell carcinoma_Homo sapiens_hsa052170.23211863
1122-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.21891495
113Primary immunodeficiency_Homo sapiens_hsa053400.20094202
114Epstein-Barr virus infection_Homo sapiens_hsa051690.19664270
115Fructose and mannose metabolism_Homo sapiens_hsa000510.19059615
116Fat digestion and absorption_Homo sapiens_hsa049750.18330383

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