DNAJC19P5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neutrophil activation involved in immune response (GO:0002283)5.38287383
2positive regulation of gamma-delta T cell activation (GO:0046645)5.30438829
3response to peptidoglycan (GO:0032494)5.02107959
4detection of molecule of bacterial origin (GO:0032490)5.01777654
5positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.98241763
6cellular extravasation (GO:0045123)4.57219274
7regulation of B cell receptor signaling pathway (GO:0050855)4.57073142
8positive regulation by symbiont of host defense response (GO:0052509)4.52212285
9modulation by symbiont of host defense response (GO:0052031)4.52212285
10modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.52212285
11modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.52212285
12positive regulation by organism of defense response of other organism involved in symbiotic interact4.52212285
13modulation by symbiont of host immune response (GO:0052553)4.52212285
14macrophage activation involved in immune response (GO:0002281)4.18846515
15microglial cell activation (GO:0001774)4.11421438
16neutrophil mediated immunity (GO:0002446)3.97644888
17regulation of gamma-delta T cell differentiation (GO:0045586)3.89928946
18regulation of gamma-delta T cell activation (GO:0046643)3.89812047
19monoubiquitinated protein deubiquitination (GO:0035520)3.89057916
20detection of external biotic stimulus (GO:0098581)3.85818099
21macrophage activation (GO:0042116)3.78444974
22response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.77092468
23response to host immune response (GO:0052572)3.77092468
24detection of other organism (GO:0098543)3.65024621
25positive regulation of granulocyte differentiation (GO:0030854)3.60223320
26regulation of interferon-beta biosynthetic process (GO:0045357)3.59304885
27response to muramyl dipeptide (GO:0032495)3.55639129
28myeloid cell activation involved in immune response (GO:0002275)3.53933447
29positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.52390452
30response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.50710209
31response to host (GO:0075136)3.50710209
32response to host defenses (GO:0052200)3.50710209
33neutrophil activation (GO:0042119)3.49312725
34detection of biotic stimulus (GO:0009595)3.44519939
35hepatocyte apoptotic process (GO:0097284)3.44397075
36histone H3-K36 demethylation (GO:0070544)3.41126775
37B cell receptor signaling pathway (GO:0050853)3.39820194
38myeloid leukocyte mediated immunity (GO:0002444)3.36676110
39regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.28649426
40positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.28507864
41negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.27302264
42negative regulation of cell killing (GO:0031342)3.27302264
43negative regulation of interleukin-12 production (GO:0032695)3.21629464
44histone H3-K4 trimethylation (GO:0080182)3.20701169
45granulocyte activation (GO:0036230)3.19451074
46phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.16673084
47histone H3-K9 demethylation (GO:0033169)3.13913761
48negative regulation of cAMP-mediated signaling (GO:0043951)3.13399853
49negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.13214003
50negative regulation of translation, ncRNA-mediated (GO:0040033)3.13214003
51regulation of translation, ncRNA-mediated (GO:0045974)3.13214003
52regulation of interleukin-12 biosynthetic process (GO:0045075)3.12955696
53positive regulation of B cell differentiation (GO:0045579)3.11332352
54negative regulation of erythrocyte differentiation (GO:0045647)3.09523900
55negative thymic T cell selection (GO:0045060)3.06668455
56negative regulation of B cell proliferation (GO:0030889)3.05711279
57negative T cell selection (GO:0043383)3.03459208
58detection of bacterium (GO:0016045)3.02372903
59negative regulation of T-helper cell differentiation (GO:0045623)3.01898742
60negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.01898742
61definitive hemopoiesis (GO:0060216)2.99908009
62antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.96456766
63production of molecular mediator involved in inflammatory response (GO:0002532)2.96084002
64regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.95777985
65T-helper 1 type immune response (GO:0042088)2.95580109
66positive regulation of mast cell activation (GO:0033005)2.89003749
67regulation of B cell differentiation (GO:0045577)2.87833090
68positive T cell selection (GO:0043368)2.87741844
69regulation of interleukin-6 biosynthetic process (GO:0045408)2.85588015
70negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.84366194
71histone lysine demethylation (GO:0070076)2.83959151
72histone demethylation (GO:0016577)2.83791239
73leukocyte degranulation (GO:0043299)2.83708491
74G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.83650907
75regulation of mast cell activation (GO:0033003)2.80164964
76cellular response to ethanol (GO:0071361)2.79713299
77germinal center formation (GO:0002467)2.79630581
78activated T cell proliferation (GO:0050798)2.75786617
79positive regulation of interferon-alpha production (GO:0032727)2.75317600
80embryonic process involved in female pregnancy (GO:0060136)2.75244399
81dosage compensation (GO:0007549)2.72759085
82negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.72179450
83regulation of RNA export from nucleus (GO:0046831)2.70849332
84negative regulation of lymphocyte mediated immunity (GO:0002707)2.69958795
85regulation of MHC class I biosynthetic process (GO:0045343)2.68106606
86respiratory burst (GO:0045730)2.67089922
87cytoplasmic mRNA processing body assembly (GO:0033962)2.65660247
88positive regulation of cellular amide metabolic process (GO:0034250)2.65575326
89negative regulation of B cell mediated immunity (GO:0002713)2.64574986
90negative regulation of immunoglobulin mediated immune response (GO:0002890)2.64574986
91negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.64542397
92regulation of alpha-beta T cell proliferation (GO:0046640)2.63123551
93lipopolysaccharide-mediated signaling pathway (GO:0031663)2.62736714
94myeloid leukocyte activation (GO:0002274)2.61076210
95regulation of mast cell activation involved in immune response (GO:0033006)2.60951666
96regulation of granulocyte differentiation (GO:0030852)2.60580290
97peptidyl-lysine trimethylation (GO:0018023)2.59904745
98positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.58464633
99regulation of mast cell degranulation (GO:0043304)2.57044866
100defense response to protozoan (GO:0042832)2.56775907

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.80614993
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.98905438
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.70877243
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.54649042
5GATA1_22025678_ChIP-Seq_K562_Human3.05944923
6SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.91091565
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.88537128
8STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.84345629
9SCL_19346495_ChIP-Seq_HPC-7_Human2.77250054
10IRF8_27001747_Chip-Seq_BMDM_Mouse2.67976230
11IRF8_21731497_ChIP-ChIP_J774_Mouse2.65500313
12SMAD_19615063_ChIP-ChIP_OVARY_Human2.63739580
13MYB_21317192_ChIP-Seq_ERMYB_Mouse2.63359169
14STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.50577342
15NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.50498817
16RUNX_20019798_ChIP-Seq_JUKART_Human2.48808219
17Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.48525512
18CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.28208616
19NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.27265876
20SALL1_21062744_ChIP-ChIP_HESCs_Human2.26359304
21FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.26009848
22EGR1_19374776_ChIP-ChIP_THP-1_Human2.16875124
23VDR_24787735_ChIP-Seq_THP-1_Human2.09063542
24MYB_26560356_Chip-Seq_TH2_Human2.07748815
25SPI1_23127762_ChIP-Seq_K562_Human1.95263702
26IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.87704723
27IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.86137865
28SPI1_23547873_ChIP-Seq_NB4_Human1.83404151
29MYB_26560356_Chip-Seq_TH1_Human1.74875393
30VDR_24763502_ChIP-Seq_THP-1_Human1.65509008
31GATA3_27048872_Chip-Seq_THYMUS_Human1.56895395
32BRD4_27068464_Chip-Seq_AML-cells_Mouse1.51327184
33PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.46557969
34POU3F2_20337985_ChIP-ChIP_501MEL_Human1.46142331
35MAF_26560356_Chip-Seq_TH1_Human1.45693246
36GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.44559007
37GATA1_19941826_ChIP-Seq_K562_Human1.41497987
38PU_27001747_Chip-Seq_BMDM_Mouse1.39740035
39CDX2_19796622_ChIP-Seq_MESCs_Mouse1.39562606
40STAT4_19710469_ChIP-ChIP_TH1__Mouse1.35434474
41GATA1_19941827_ChIP-Seq_MEL_Mouse1.32585645
42GATA2_19941826_ChIP-Seq_K562_Human1.32151503
43SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.30606555
44GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30221610
45BP1_19119308_ChIP-ChIP_Hs578T_Human1.29150541
46TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.28666096
47TP53_16413492_ChIP-PET_HCT116_Human1.26170612
48RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.24795049
49RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.24674640
50NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.23584060
51RUNX1_22412390_ChIP-Seq_EML_Mouse1.23564178
52GATA3_26560356_Chip-Seq_TH2_Human1.23466951
53CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.21792478
54TCF7_22412390_ChIP-Seq_EML_Mouse1.20801802
55E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.17299644
56SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.16419260
57SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.15371350
58TAF15_26573619_Chip-Seq_HEK293_Human1.13757354
59ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.12032090
60VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.10074709
61FOXO3_23340844_ChIP-Seq_DLD1_Human1.09617002
62SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.07303984
63AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.07091554
64FOXM1_23109430_ChIP-Seq_U2OS_Human1.05249485
65FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.04747646
66CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.04084642
67ESR1_20079471_ChIP-ChIP_T-47D_Human1.02973060
68ER_23166858_ChIP-Seq_MCF-7_Human1.02079439
69KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.02019704
70SALL4_18804426_ChIP-ChIP_XEN_Mouse1.01777016
71SALL4_22934838_ChIP-ChIP_CD34+_Human0.99776876
72VDR_21846776_ChIP-Seq_THP-1_Human0.98499977
73UTX_26944678_Chip-Seq_JUKART_Human0.96225966
74EZH2_27294783_Chip-Seq_NPCs_Mouse0.96016047
75SMRT_27268052_Chip-Seq_Bcells_Human0.95856989
76CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.95778889
77MYC_22102868_ChIP-Seq_BL_Human0.92836045
78GATA1_19941827_ChIP-Seq_MEL86_Mouse0.92185901
79GATA2_22383799_ChIP-Seq_G1ME_Mouse0.90875668
80PKCTHETA_26484144_Chip-Seq_BREAST_Human0.90294420
81ZNF217_24962896_ChIP-Seq_MCF-7_Human0.89920225
82FLI1_27457419_Chip-Seq_LIVER_Mouse0.88834664
83GATA2_21666600_ChIP-Seq_HMVEC_Human0.88736130
84FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.88720808
85OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.87354084
86STAT3_23295773_ChIP-Seq_U87_Human0.86442200
87SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.85265275
88FOXM1_26456572_ChIP-Seq_MCF-7_Human0.84492603
89KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.84374472
90POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.83260176
91TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83260176
92RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.82508550
93BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.80962698
94CTNNB1_20460455_ChIP-Seq_HCT116_Human0.80136493
95MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.79491793
96STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.78774754
97FLI1_21867929_ChIP-Seq_TH2_Mouse0.78748159
98AR_21572438_ChIP-Seq_LNCaP_Human0.78597206
99TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.77739843
100TP63_23658742_ChIP-Seq_EP156T_Human0.76643289

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation3.95697727
2MP0008057_abnormal_DNA_replication3.84565911
3MP0003656_abnormal_erythrocyte_physiolo3.77304187
4MP0003724_increased_susceptibility_to3.59945875
5MP0003303_peritoneal_inflammation3.00162903
6MP0003172_abnormal_lysosome_physiology2.90135641
7MP0001835_abnormal_antigen_presentation2.87438613
8MP0003436_decreased_susceptibility_to2.64898222
9MP0008260_abnormal_autophagy2.54680376
10MP0002419_abnormal_innate_immunity2.48962200
11MP0001800_abnormal_humoral_immune2.30729817
12MP0003828_pulmonary_edema2.22251041
13MP0005464_abnormal_platelet_physiology2.21570198
14MP0002009_preneoplasia2.18492952
15MP0002396_abnormal_hematopoietic_system2.15682947
16MP0005000_abnormal_immune_tolerance2.15674927
17MP0003763_abnormal_thymus_physiology2.10753439
18MP0005174_abnormal_tail_pigmentation2.08571482
19MP0004808_abnormal_hematopoietic_stem2.05505904
20MP0002723_abnormal_immune_serum1.99386528
21MP0002452_abnormal_antigen_presenting1.95981747
22MP0002420_abnormal_adaptive_immunity1.94260421
23MP0001819_abnormal_immune_cell1.91071896
24MP0002398_abnormal_bone_marrow1.89973113
25MP0005025_abnormal_response_to1.85439522
26MP0000015_abnormal_ear_pigmentation1.85429088
27MP0002405_respiratory_system_inflammati1.85395679
28MP0005397_hematopoietic_system_phenotyp1.84368871
29MP0001545_abnormal_hematopoietic_system1.84368871
30MP0004883_abnormal_blood_vessel1.80910982
31MP0002166_altered_tumor_susceptibility1.77541765
32MP0005387_immune_system_phenotype1.73395044
33MP0001790_abnormal_immune_system1.73395044
34MP0009785_altered_susceptibility_to1.66461380
35MP0000716_abnormal_immune_system1.63742183
36MP0001851_eye_inflammation1.59903223
37MP0000689_abnormal_spleen_morphology1.58859729
38MP0001853_heart_inflammation1.57994635
39MP0002722_abnormal_immune_system1.57237014
40MP0005164_abnormal_response_to1.54786877
41MP0006082_CNS_inflammation1.54169947
42MP0000703_abnormal_thymus_morphology1.54017203
43MP0004381_abnormal_hair_follicle1.52487709
44MP0004947_skin_inflammation1.49956492
45MP0005076_abnormal_cell_differentiation1.42392071
46MP0005409_darkened_coat_color1.39289269
47MP0002148_abnormal_hypersensitivity_rea1.38060871
48MP0005451_abnormal_body_composition1.37090655
49MP0003300_gastrointestinal_ulcer1.35412950
50MP0000465_gastrointestinal_hemorrhage1.35409453
51MP0000685_abnormal_immune_system1.35332872
52MP0002132_abnormal_respiratory_system1.33573246
53MP0009278_abnormal_bone_marrow1.32799516
54MP0002429_abnormal_blood_cell1.32233980
55MP0003787_abnormal_imprinting1.31793699
56MP0008961_abnormal_basal_metabolism1.31443300
57MP0003191_abnormal_cellular_cholesterol1.29707660
58MP0003221_abnormal_cardiomyocyte_apopto1.29062197
59MP0002006_tumorigenesis1.22468899
60MP0006054_spinal_hemorrhage1.21122033
61MP0005671_abnormal_response_to1.20936678
62MP0002998_abnormal_bone_remodeling1.20461508
63MP0001845_abnormal_inflammatory_respons1.20019254
64MP0002332_abnormal_exercise_endurance1.19662924
65MP0009764_decreased_sensitivity_to1.18996448
66MP0005310_abnormal_salivary_gland1.18165820
67MP0010155_abnormal_intestine_physiology1.13455744
68MP0010352_gastrointestinal_tract_polyps1.09991649
69MP0005075_abnormal_melanosome_morpholog1.09360420
70MP0001533_abnormal_skeleton_physiology1.04492891
71MP0000858_altered_metastatic_potential1.01099499
72MP0004484_altered_response_of0.96031744
73MP0003091_abnormal_cell_migration0.88950221
74MP0004510_myositis0.87658726
75MP0009115_abnormal_fat_cell0.87406790
76MP0000249_abnormal_blood_vessel0.86534270
77MP0003690_abnormal_glial_cell0.84835787
78MP0008469_abnormal_protein_level0.83612364
79MP0005248_abnormal_Harderian_gland0.83574906
80MP0003075_altered_response_to0.83017037
81MP0009763_increased_sensitivity_to0.78973778
82MP0009765_abnormal_xenobiotic_induced0.78476570
83MP0005376_homeostasis/metabolism_phenot0.77510452
84MP0005621_abnormal_cell_physiology0.77212720
85MP0004264_abnormal_extraembryonic_tissu0.76131796
86MP0001915_intracranial_hemorrhage0.75520551
87MP0003448_altered_tumor_morphology0.75292082
88MP0003252_abnormal_bile_duct0.74172849
89MP0005266_abnormal_metabolism0.73177442
90MP0005083_abnormal_biliary_tract0.72869436
91MP0008877_abnormal_DNA_methylation0.72319388
92MP0002019_abnormal_tumor_incidence0.71847562
93MP0004130_abnormal_muscle_cell0.71343302
94MP0008004_abnormal_stomach_pH0.70156785
95MP0001986_abnormal_taste_sensitivity0.67671542
96MP0009333_abnormal_splenocyte_physiolog0.60780738
97MP0000371_diluted_coat_color0.60495537
98MP0003453_abnormal_keratinocyte_physiol0.58766165
99MP0005666_abnormal_adipose_tissue0.58573714
100MP0001784_abnormal_fluid_regulation0.56424901

Predicted human phenotypes

RankGene SetZ-score
1Recurrent bacterial skin infections (HP:0005406)4.59487322
2Recurrent abscess formation (HP:0002722)4.11768198
3Gingival bleeding (HP:0000225)3.83991163
4Prolonged bleeding time (HP:0003010)3.57914796
5Gastrointestinal infarctions (HP:0005244)3.51671406
6Papillary thyroid carcinoma (HP:0002895)3.47225753
7Genetic anticipation (HP:0003743)3.46781182
8Eczematoid dermatitis (HP:0000976)3.43242984
9T lymphocytopenia (HP:0005403)3.39381849
10Acute myeloid leukemia (HP:0004808)3.33481461
11Optic neuritis (HP:0100653)3.32786300
12Retrobulbar optic neuritis (HP:0100654)3.32786300
13Abnormality of T cell number (HP:0011839)3.27013091
14Recurrent fungal infections (HP:0002841)3.25102571
15Abnormality of the fingertips (HP:0001211)3.17300533
16Orchitis (HP:0100796)3.17239450
17Myositis (HP:0100614)3.16892611
18Recurrent skin infections (HP:0001581)3.13622663
19Epistaxis (HP:0000421)3.12286523
20Keratoconjunctivitis sicca (HP:0001097)3.11427387
21Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.07246505
22Chronic mucocutaneous candidiasis (HP:0002728)3.05567375
23Recurrent cutaneous fungal infections (HP:0011370)3.05567375
24Poikilocytosis (HP:0004447)2.99316443
25Stomatitis (HP:0010280)2.98394892
26Chest pain (HP:0100749)2.96526884
27Keratoconjunctivitis (HP:0001096)2.94849823
28Spontaneous hematomas (HP:0007420)2.91640986
29Subacute progressive viral hepatitis (HP:0006572)2.90745383
30Fatigue (HP:0012378)2.89896874
31Slow saccadic eye movements (HP:0000514)2.89146395
32Abnormal delayed hypersensitivity skin test (HP:0002963)2.83731314
33Arterial thrombosis (HP:0004420)2.82745333
34Abnormality of macrophages (HP:0004311)2.81939076
35Recurrent gram-negative bacterial infections (HP:0005420)2.72610714
36Facial hemangioma (HP:0000329)2.59696019
37Recurrent viral infections (HP:0004429)2.59372655
38Gingivitis (HP:0000230)2.58611107
39Leukocytosis (HP:0001974)2.58305956
40Abnormal platelet volume (HP:0011876)2.55796522
41Elevated erythrocyte sedimentation rate (HP:0003565)2.55128256
42Viral hepatitis (HP:0006562)2.54547191
43Long clavicles (HP:0000890)2.51579040
44Acanthocytosis (HP:0001927)2.47646993
45Vasculitis (HP:0002633)2.45425906
46Mediastinal lymphadenopathy (HP:0100721)2.45282057
47Disinhibition (HP:0000734)2.43338905
48Peritonitis (HP:0002586)2.41629000
49Increased mean platelet volume (HP:0011877)2.32967484
50Encephalitis (HP:0002383)2.29791834
51Meningitis (HP:0001287)2.29161534
52Polycythemia (HP:0001901)2.29023087
53Abnormality of T cells (HP:0002843)2.21010991
54Lower limb hyperreflexia (HP:0002395)2.19431524
55Eosinophilia (HP:0001880)2.19099302
56Hemoptysis (HP:0002105)2.17564537
57Truncal obesity (HP:0001956)2.13192844
58Chronic obstructive pulmonary disease (HP:0006510)2.12518986
59Obstructive lung disease (HP:0006536)2.12518986
60Postural instability (HP:0002172)2.10233889
61Granulocytopenia (HP:0001913)2.09793336
62Abnormal hair whorl (HP:0010721)2.08979077
63Colitis (HP:0002583)2.08194008
64Thyroid carcinoma (HP:0002890)2.07980197
65Inflammation of the large intestine (HP:0002037)2.07390438
66Acute hepatic failure (HP:0006554)2.05805057
67Neoplasm of the tracheobronchial system (HP:0100552)2.05295809
68Narrow palate (HP:0000189)2.04993024
69Hepatoblastoma (HP:0002884)2.04549423
70Conjunctival telangiectasia (HP:0000524)2.04333199
71Heterotopia (HP:0002282)2.03795453
72Autoimmune hemolytic anemia (HP:0001890)2.02031675
73Abnormality of the vasculature of the conjunctiva (HP:0008054)2.00797271
74Stomach cancer (HP:0012126)2.00188733
75Abnormality of incisor morphology (HP:0011063)1.98862769
76Urticaria (HP:0001025)1.96106175
77Pulmonary embolism (HP:0002204)1.96095417
78Gangrene (HP:0100758)1.94414494
79Amaurosis fugax (HP:0100576)1.92568694
80Abnormality of eosinophils (HP:0001879)1.92514751
81Menorrhagia (HP:0000132)1.92409745
82Panhypogammaglobulinemia (HP:0003139)1.92278528
83Periodontitis (HP:0000704)1.91763059
84Abnormality of the columella (HP:0009929)1.91709045
85Hematochezia (HP:0002573)1.88003163
86Cystic hygroma (HP:0000476)1.86294875
87Somatic mutation (HP:0001428)1.84946216
88Widely spaced teeth (HP:0000687)1.83749647
89Facial diplegia (HP:0001349)1.81111684
90Thrombophlebitis (HP:0004418)1.80376980
91Gastrointestinal inflammation (HP:0004386)1.79538089
92Low anterior hairline (HP:0000294)1.78994465
93Pulmonary infiltrates (HP:0002113)1.77882537
94Menstrual irregularities (HP:0000858)1.77024844
95Abnormality of the left ventricular outflow tract (HP:0011103)1.76683298
96Subaortic stenosis (HP:0001682)1.76683298
97Episodic fever (HP:0001954)1.75226820
98Spondylolisthesis (HP:0003302)1.74445813
99Transitional cell carcinoma of the bladder (HP:0006740)1.73582326
100Curly hair (HP:0002212)1.70057131

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK43.46768535
2BMPR22.66218741
3MAP3K22.62830103
4FRK2.40931499
5BLK2.40716060
6YES12.31280834
7IRAK42.25467582
8MAP2K32.18747817
9PIK3CG2.11123148
10MAP3K142.09081480
11TXK2.08204161
12SGK21.89715128
13MAP3K61.70912697
14NLK1.70534693
15IKBKE1.64461225
16SGK31.63803522
17CSK1.61356779
18WNK11.61114062
19BRD41.58733346
20GRK61.58590820
21BTK1.57413775
22TAOK31.54881962
23AKT31.54688876
24JAK31.53349580
25TYK21.52292512
26SYK1.51575585
27TEC1.50750347
28ZAP701.50739323
29FES1.48176817
30MAP4K11.47555033
31CDK121.46817621
32FGFR31.43557750
33ACVR1B1.42033701
34IRAK11.35097758
35STK101.34288631
36HCK1.33560779
37MARK21.32017061
38JAK11.31476574
39BRSK21.26967481
40JAK21.26692064
41MARK31.18597015
42KSR21.14839755
43IRAK21.12631766
44TAOK11.09836638
45FGR1.05167490
46EIF2AK11.01857982
47LYN1.01601876
48SGK2231.01136732
49SGK4941.01136732
50PRPF4B0.97420573
51TNK20.95886799
52PTK2B0.95458676
53ITK0.94642414
54TGFBR20.92086417
55RAF10.91975873
56STK40.89229234
57PIM10.85814345
58CAMK1D0.84806665
59CDK60.79384733
60MAPK70.77539602
61SGK10.76379094
62MST40.75582271
63IKBKB0.74250887
64CHUK0.74083218
65ERBB20.73700660
66CAMK40.73109387
67LCK0.72879627
68TRPM70.71381612
69PDK10.70195709
70MKNK20.69755863
71MELK0.67217547
72CLK10.67093911
73MAP3K10.66983735
74MAP3K30.65926932
75HIPK20.64350460
76SIK30.62573158
77KSR10.62103920
78MAP2K40.61915224
79NEK60.59626572
80RET0.56838743
81EIF2AK20.56360074
82CAMK1G0.54791823
83ERN10.54514819
84LRRK20.54054242
85TNIK0.50657906
86STK110.50573067
87MAP3K50.49816528
88BMPR1B0.48304871
89TBK10.48238589
90NEK90.47975407
91ERBB30.46793368
92STK380.46360421
93CSF1R0.44094003
94EGFR0.44078647
95CDC42BPA0.41174139
96DYRK30.40281855
97CAMKK20.38871202
98DYRK1B0.38578366
99MAP3K100.38484986
100KIT0.38312951

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051402.54577917
2NOD-like receptor signaling pathway_Homo sapiens_hsa046212.53971585
3Osteoclast differentiation_Homo sapiens_hsa043802.34733663
4B cell receptor signaling pathway_Homo sapiens_hsa046622.06503063
5Toll-like receptor signaling pathway_Homo sapiens_hsa046201.85965437
6Tuberculosis_Homo sapiens_hsa051521.83074248
7Acute myeloid leukemia_Homo sapiens_hsa052211.75703630
8Measles_Homo sapiens_hsa051621.75466990
9Staphylococcus aureus infection_Homo sapiens_hsa051501.75052405
10Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.72065022
11Non-small cell lung cancer_Homo sapiens_hsa052231.70269861
12NF-kappa B signaling pathway_Homo sapiens_hsa040641.67584445
13Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.66184916
14Legionellosis_Homo sapiens_hsa051341.65450479
15Influenza A_Homo sapiens_hsa051641.63940592
16RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.62549720
17FoxO signaling pathway_Homo sapiens_hsa040681.61467183
18T cell receptor signaling pathway_Homo sapiens_hsa046601.59812656
19Malaria_Homo sapiens_hsa051441.56896255
20TNF signaling pathway_Homo sapiens_hsa046681.52810789
21Chronic myeloid leukemia_Homo sapiens_hsa052201.52336687
22Jak-STAT signaling pathway_Homo sapiens_hsa046301.51735784
23Hematopoietic cell lineage_Homo sapiens_hsa046401.49391967
24Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.45409951
25Circadian rhythm_Homo sapiens_hsa047101.43138689
26Hepatitis B_Homo sapiens_hsa051611.41983007
27Pancreatic cancer_Homo sapiens_hsa052121.40181029
28Toxoplasmosis_Homo sapiens_hsa051451.39498960
29Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.39306154
30Platelet activation_Homo sapiens_hsa046111.37551956
31Renal cell carcinoma_Homo sapiens_hsa052111.37346432
32Inositol phosphate metabolism_Homo sapiens_hsa005621.29816380
33Phosphatidylinositol signaling system_Homo sapiens_hsa040701.29115792
34Herpes simplex infection_Homo sapiens_hsa051681.27314927
35AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.25151742
36Dorso-ventral axis formation_Homo sapiens_hsa043201.24701721
37Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.24603273
38Chemokine signaling pathway_Homo sapiens_hsa040621.22646109
39Graft-versus-host disease_Homo sapiens_hsa053321.21407861
40Neurotrophin signaling pathway_Homo sapiens_hsa047221.18206308
41Endometrial cancer_Homo sapiens_hsa052131.14796355
42Prostate cancer_Homo sapiens_hsa052151.14040559
43Prolactin signaling pathway_Homo sapiens_hsa049171.12249354
44mTOR signaling pathway_Homo sapiens_hsa041501.05160706
45Transcriptional misregulation in cancer_Homo sapiens_hsa052021.04832006
46ErbB signaling pathway_Homo sapiens_hsa040121.02791138
47Colorectal cancer_Homo sapiens_hsa052100.99776420
48Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.99234970
49Hepatitis C_Homo sapiens_hsa051600.96694524
50African trypanosomiasis_Homo sapiens_hsa051430.95043385
51Choline metabolism in cancer_Homo sapiens_hsa052310.93547222
52VEGF signaling pathway_Homo sapiens_hsa043700.91257279
53Leukocyte transendothelial migration_Homo sapiens_hsa046700.89491172
54Pertussis_Homo sapiens_hsa051330.86885611
55Primary immunodeficiency_Homo sapiens_hsa053400.85546503
56Allograft rejection_Homo sapiens_hsa053300.85387718
57Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.82237416
58Viral carcinogenesis_Homo sapiens_hsa052030.81720201
59Glioma_Homo sapiens_hsa052140.79969496
60Thyroid hormone signaling pathway_Homo sapiens_hsa049190.79591263
61Autoimmune thyroid disease_Homo sapiens_hsa053200.79552729
62MicroRNAs in cancer_Homo sapiens_hsa052060.79032477
63Apoptosis_Homo sapiens_hsa042100.78742087
64Phospholipase D signaling pathway_Homo sapiens_hsa040720.77997302
65Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.76500379
66Sphingolipid signaling pathway_Homo sapiens_hsa040710.76243637
67Thyroid cancer_Homo sapiens_hsa052160.76019594
68Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.75742079
69Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.71881880
70Carbohydrate digestion and absorption_Homo sapiens_hsa049730.71033430
71HIF-1 signaling pathway_Homo sapiens_hsa040660.70415203
72GnRH signaling pathway_Homo sapiens_hsa049120.69052538
73Insulin resistance_Homo sapiens_hsa049310.68265206
74Intestinal immune network for IgA production_Homo sapiens_hsa046720.67977565
75Notch signaling pathway_Homo sapiens_hsa043300.67664287
76Other glycan degradation_Homo sapiens_hsa005110.65638723
77Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.65583068
78Amoebiasis_Homo sapiens_hsa051460.63739033
79Asthma_Homo sapiens_hsa053100.62204182
80Type I diabetes mellitus_Homo sapiens_hsa049400.60791538
81Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.60238893
82Shigellosis_Homo sapiens_hsa051310.59421370
83Long-term potentiation_Homo sapiens_hsa047200.58976477
84MAPK signaling pathway_Homo sapiens_hsa040100.58225190
85Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.58133161
86Epstein-Barr virus infection_Homo sapiens_hsa051690.58076647
87Small cell lung cancer_Homo sapiens_hsa052220.57094662
88HTLV-I infection_Homo sapiens_hsa051660.55538260
89Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.55365010
90Type II diabetes mellitus_Homo sapiens_hsa049300.55212840
91Antigen processing and presentation_Homo sapiens_hsa046120.52759948
92Adipocytokine signaling pathway_Homo sapiens_hsa049200.52699948
93Longevity regulating pathway - mammal_Homo sapiens_hsa042110.52071422
94Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.49703421
95Steroid biosynthesis_Homo sapiens_hsa001000.49456415
96Fatty acid biosynthesis_Homo sapiens_hsa000610.49017691
97Glycerophospholipid metabolism_Homo sapiens_hsa005640.48424649
98Salmonella infection_Homo sapiens_hsa051320.46007652
99Rheumatoid arthritis_Homo sapiens_hsa053230.44832789
100Phagosome_Homo sapiens_hsa041450.44374908

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