ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	somatic diversification of immune receptors via somatic mutation (GO:0002566)	6.10866552
2	somatic hypermutation of immunoglobulin genes (GO:0016446)	6.10866552
3	resolution of meiotic recombination intermediates (GO:0000712)	5.38487665
4	opioid receptor signaling pathway (GO:0038003)	5.37376806
5	histone H2A acetylation (GO:0043968)	5.23230545
6	positive regulation of megakaryocyte differentiation (GO:0045654)	4.80219102
7	neurotransmitter catabolic process (GO:0042135)	4.73520288
8	meiotic chromosome segregation (GO:0045132)	4.55975200
9	double-strand break repair via nonhomologous end joining (GO:0006303)	4.46249192
10	non-recombinational repair (GO:0000726)	4.46249192
11	synapsis (GO:0007129)	4.43257645
12	synaptic vesicle docking involved in exocytosis (GO:0016081)	4.36816497
13	replication fork processing (GO:0031297)	4.34389339
14	DNA ligation (GO:0006266)	4.33514123
15	epithelial cilium movement (GO:0003351)	4.32230551
16	positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)	4.29156124
17	negative regulation of DNA recombination (GO:0045910)	4.24012785
18	positive regulation of neurotransmitter secretion (GO:0001956)	4.18018875
19	regulation of short-term neuronal synaptic plasticity (GO:0048172)	4.17305011
20	negative regulation of DNA-dependent DNA replication (GO:2000104)	4.08950705
21	DNA strand renaturation (GO:0000733)	4.04283725
22	metaphase plate congression (GO:0051310)	3.97483088
23	ncRNA 3-end processing (GO:0043628)	3.75339248
24	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.74030805
25	DNA replication checkpoint (GO:0000076)	3.73976900
26	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.67008239
27	isotype switching (GO:0045190)	3.64827215
28	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	3.64827215
29	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	3.64827215
30	mitotic sister chromatid cohesion (GO:0007064)	3.62816863
31	intra-S DNA damage checkpoint (GO:0031573)	3.60411848
32	protein polyglutamylation (GO:0018095)	3.59464111
33	regulation of Wnt signaling pathway involved in heart development (GO:0003307)	3.56872958
34	GMP metabolic process (GO:0046037)	3.43986594
35	response to UV-B (GO:0010224)	3.37829659
36	DNA replication-dependent nucleosome assembly (GO:0006335)	3.35383901
37	DNA replication-dependent nucleosome organization (GO:0034723)	3.35383901
38	cilium movement (GO:0003341)	3.34955751
39	establishment of integrated proviral latency (GO:0075713)	3.33970400
40	single strand break repair (GO:0000012)	3.31132881
41	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	3.27745534
42	regulation of non-canonical Wnt signaling pathway (GO:2000050)	3.25482990
43	regulation of mitotic spindle checkpoint (GO:1903504)	3.22297628
44	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	3.22297628
45	inner mitochondrial membrane organization (GO:0007007)	3.21598782
46	anterograde synaptic vesicle transport (GO:0048490)	3.19510534
47	regulation of helicase activity (GO:0051095)	3.19324888
48	nuclear pore complex assembly (GO:0051292)	3.15121880
49	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	3.13296484
50	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.07543717
51	somatic diversification of immunoglobulins (GO:0016445)	3.06468370
52	protein neddylation (GO:0045116)	3.05449304
53	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.05439638
54	termination of RNA polymerase III transcription (GO:0006386)	3.05439638
55	mitotic sister chromatid segregation (GO:0000070)	3.05023995
56	chromatin remodeling at centromere (GO:0031055)	3.04986395
57	IMP biosynthetic process (GO:0006188)	3.02004812
58	cartilage morphogenesis (GO:0060536)	2.99416040
59	protein localization to kinetochore (GO:0034501)	2.99051694
60	kinetochore assembly (GO:0051382)	2.97593650
61	DNA double-strand break processing (GO:0000729)	2.96083307
62	regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)	2.96040270
63	positive regulation of neurotransmitter transport (GO:0051590)	2.95386507
64	cullin deneddylation (GO:0010388)	2.95190684
65	response to X-ray (GO:0010165)	2.93303443
66	sister chromatid segregation (GO:0000819)	2.92628607
67	innervation (GO:0060384)	2.91016520
68	CENP-A containing nucleosome assembly (GO:0034080)	2.89037335
69	kinetochore organization (GO:0051383)	2.87470883
70	somatic recombination of immunoglobulin gene segments (GO:0016447)	2.87239479
71	female gonad development (GO:0008585)	2.85760970
72	mitotic metaphase plate congression (GO:0007080)	2.84685984
73	purine nucleobase biosynthetic process (GO:0009113)	2.83414098
74	intraciliary transport (GO:0042073)	2.83144557
75	nuclear pore organization (GO:0006999)	2.81195000
76	dorsal/ventral axis specification (GO:0009950)	2.80282775
77	lysine metabolic process (GO:0006553)	2.79356074
78	lysine catabolic process (GO:0006554)	2.79356074
79	glyoxylate metabolic process (GO:0046487)	2.78492378
80	mismatch repair (GO:0006298)	2.77178538
81	somatic diversification of immune receptors (GO:0002200)	2.76428075
82	axon extension involved in axon guidance (GO:0048846)	2.76058183
83	neuron projection extension involved in neuron projection guidance (GO:1902284)	2.76058183
84	aspartate family amino acid catabolic process (GO:0009068)	2.75843253
85	thalamus development (GO:0021794)	2.72663520
86	lactate metabolic process (GO:0006089)	2.71781418
87	histone exchange (GO:0043486)	2.71369358
88	establishment of chromosome localization (GO:0051303)	2.70076337
89	pseudouridine synthesis (GO:0001522)	2.68778094
90	respiratory chain complex IV assembly (GO:0008535)	2.67587917
91	embryonic skeletal joint morphogenesis (GO:0060272)	2.66556954
92	establishment of viral latency (GO:0019043)	2.65658147
93	protein deneddylation (GO:0000338)	2.63857178
94	L-serine metabolic process (GO:0006563)	2.62062456
95	somatic cell DNA recombination (GO:0016444)	2.60295185
96	somatic diversification of immune receptors via germline recombination within a single locus (GO:000	2.60295185
97	transcription from mitochondrial promoter (GO:0006390)	2.59909157
98	DNA catabolic process, exonucleolytic (GO:0000738)	2.59626078
99	anterograde axon cargo transport (GO:0008089)	2.59153715
100	positive regulation of smoothened signaling pathway (GO:0045880)	2.57843493

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SALL1_21062744_ChIP-ChIP_HESCs_Human	4.62289380
2	E2F7_22180533_ChIP-Seq_HELA_Human	4.38432061
3	ZNF274_21170338_ChIP-Seq_K562_Hela	3.75674761
4	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.61980500
5	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.03572089
6	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.89715579
7	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.88462060
8	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.81030668
9	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.73406523
10	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.49548773
11	IGF1R_20145208_ChIP-Seq_DFB_Human	2.38627519
12	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.34143627
13	FUS_26573619_Chip-Seq_HEK293_Human	2.32502370
14	EWS_26573619_Chip-Seq_HEK293_Human	2.28139605
15	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.19555426
16	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.02292565
17	ELK1_19687146_ChIP-ChIP_HELA_Human	1.98795550
18	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.95330077
19	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.92388634
20	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.92134906
21	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.91984394
22	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.90249391
23	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.89710017
24	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.86469586
25	TAF15_26573619_Chip-Seq_HEK293_Human	1.82306496
26	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.78966222
27	P300_19829295_ChIP-Seq_ESCs_Human	1.78294687
28	VDR_22108803_ChIP-Seq_LS180_Human	1.73190046
29	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.70540392
30	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.67730881
31	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.65042768
32	AR_21909140_ChIP-Seq_LNCAP_Human	1.59135209
33	BCAT_22108803_ChIP-Seq_LS180_Human	1.57780425
34	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.57188263
35	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.57073834
36	NANOG_16153702_ChIP-ChIP_HESCs_Human	1.53645216
37	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.50809061
38	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.50077531
39	MYC_18940864_ChIP-ChIP_HL60_Human	1.49489539
40	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.49191369
41	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.47435869
42	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.47066845
43	GBX2_23144817_ChIP-Seq_PC3_Human	1.46708080
44	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.45911180
45	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.44045938
46	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.40430788
47	VDR_23849224_ChIP-Seq_CD4+_Human	1.40341145
48	FOXM1_23109430_ChIP-Seq_U2OS_Human	1.40262429
49	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.37731439
50	IRF1_19129219_ChIP-ChIP_H3396_Human	1.37025076
51	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.34402384
52	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.33260156
53	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.32043682
54	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.29135938
55	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.28761263
56	FOXP3_21729870_ChIP-Seq_TREG_Human	1.26021765
57	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.25325557
58	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.17609858
59	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.16506015
60	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.16463044
61	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.16235342
62	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.16166180
63	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.15322467
64	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.14329290
65	ER_23166858_ChIP-Seq_MCF-7_Human	1.13241084
66	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.12743186
67	DCP1A_22483619_ChIP-Seq_HELA_Human	1.12096349
68	SOX2_19829295_ChIP-Seq_ESCs_Human	1.11807148
69	NANOG_19829295_ChIP-Seq_ESCs_Human	1.11807148
70	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.09695198
71	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.08191131
72	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.08120113
73	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.05370494
74	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.05065638
75	CBP_20019798_ChIP-Seq_JUKART_Human	1.05065638
76	SOX2_18555785_ChIP-Seq_MESCs_Mouse	1.04879442
77	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.04537511
78	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.04470124
79	SMAD4_21799915_ChIP-Seq_A2780_Human	1.02463910
80	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.02159021
81	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.00492033
82	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	0.99825723
83	NOTCH1_21737748_ChIP-Seq_TLL_Human	0.99521445
84	TCF4_22108803_ChIP-Seq_LS180_Human	0.99188659
85	E2F1_18555785_ChIP-Seq_MESCs_Mouse	0.98463035
86	NANOG_18555785_ChIP-Seq_MESCs_Mouse	0.97920182
87	SALL4_22934838_ChIP-ChIP_CD34+_Human	0.97822476
88	MYC_18358816_ChIP-ChIP_MESCs_Mouse	0.97580941
89	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.97448335
90	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.97448335
91	AR_25329375_ChIP-Seq_VCAP_Human	0.95095070
92	NANOG_18358816_ChIP-ChIP_MESCs_Mouse	0.93658844
93	E2F1_21310950_ChIP-Seq_MCF-7_Human	0.93602062
94	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.92727814
95	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	0.92289489
96	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.91272039
97	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.91131370
98	STAT3_23295773_ChIP-Seq_U87_Human	0.90931494
99	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.90748270
100	TTF2_22483619_ChIP-Seq_HELA_Human	0.90702436

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003890_abnormal_embryonic-extraembry	4.07841362
2	MP0008058_abnormal_DNA_repair	3.19166029
3	MP0000372_irregular_coat_pigmentation	3.08410619
4	MP0003937_abnormal_limbs/digits/tail_de	2.76500580
5	MP0010094_abnormal_chromosome_stability	2.61747580
6	MP0001293_anophthalmia	2.61301360
7	MP0008007_abnormal_cellular_replicative	2.60230023
8	MP0010030_abnormal_orbit_morphology	2.51168297
9	MP0003941_abnormal_skin_development	2.44939764
10	MP0001529_abnormal_vocalization	2.40113208
11	MP0006292_abnormal_olfactory_placode	2.28249890
12	MP0004133_heterotaxia	2.21230663
13	MP0008932_abnormal_embryonic_tissue	2.14296761
14	MP0008877_abnormal_DNA_methylation	2.12962875
15	MP0004147_increased_porphyrin_level	2.11224711
16	MP0009697_abnormal_copulation	2.07181928
17	MP0002249_abnormal_larynx_morphology	2.05338395
18	MP0003121_genomic_imprinting	2.00585869
19	MP0003195_calcinosis	1.90111524
20	MP0002282_abnormal_trachea_morphology	1.88914452
21	MP0003567_abnormal_fetal_cardiomyocyte	1.84997854
22	MP0004957_abnormal_blastocyst_morpholog	1.83425973
23	MP0003111_abnormal_nucleus_morphology	1.81075028
24	MP0002938_white_spotting	1.78750102
25	MP0003122_maternal_imprinting	1.77466837
26	MP0003077_abnormal_cell_cycle	1.75037117
27	MP0009250_abnormal_appendicular_skeleto	1.71644393
28	MP0005084_abnormal_gallbladder_morpholo	1.68877735
29	MP0003787_abnormal_imprinting	1.68477640
30	MP0001984_abnormal_olfaction	1.68450410
31	MP0006054_spinal_hemorrhage	1.60717013
32	MP0003646_muscle_fatigue	1.56574926
33	MP0003806_abnormal_nucleotide_metabolis	1.48751470
34	MP0006072_abnormal_retinal_apoptosis	1.48664461
35	MP0005367_renal/urinary_system_phenotyp	1.43782874
36	MP0000516_abnormal_urinary_system	1.43782874
37	MP0003718_maternal_effect	1.41597748
38	MP0002102_abnormal_ear_morphology	1.40529779
39	MP0002233_abnormal_nose_morphology	1.31588182
40	MP0003693_abnormal_embryo_hatching	1.29819986
41	MP0002084_abnormal_developmental_patter	1.29402202
42	MP0000579_abnormal_nail_morphology	1.28517922
43	MP0002111_abnormal_tail_morphology	1.21501308
44	MP0005551_abnormal_eye_electrophysiolog	1.20935884
45	MP0003942_abnormal_urinary_system	1.20277791
46	MP0000049_abnormal_middle_ear	1.17767721
47	MP0005310_abnormal_salivary_gland	1.16615659
48	MP0005499_abnormal_olfactory_system	1.15904762
49	MP0005394_taste/olfaction_phenotype	1.15904762
50	MP0002085_abnormal_embryonic_tissue	1.12995860
51	MP0000631_abnormal_neuroendocrine_gland	1.10782279
52	MP0003119_abnormal_digestive_system	1.10691780
53	MP0002933_joint_inflammation	1.06418899
54	MP0002109_abnormal_limb_morphology	1.05238799
55	MP0001286_abnormal_eye_development	1.03005468
56	MP0008789_abnormal_olfactory_epithelium	1.02362377
57	MP0002928_abnormal_bile_duct	1.02158172
58	MP0000462_abnormal_digestive_system	0.99934639
59	MP0003011_delayed_dark_adaptation	0.99393621
60	MP0009780_abnormal_chondrocyte_physiolo	0.97025481
61	MP0008872_abnormal_physiological_respon	0.96622557
62	MP0001730_embryonic_growth_arrest	0.96158265
63	MP0001929_abnormal_gametogenesis	0.95947094
64	MP0003755_abnormal_palate_morphology	0.95507952
65	MP0001177_atelectasis	0.94950179
66	MP0009745_abnormal_behavioral_response	0.93030574
67	MP0005380_embryogenesis_phenotype	0.93008572
68	MP0001672_abnormal_embryogenesis/_devel	0.93008572
69	MP0000647_abnormal_sebaceous_gland	0.92766269
70	MP0003315_abnormal_perineum_morphology	0.92375590
71	MP0000467_abnormal_esophagus_morphology	0.91796159
72	MP0009703_decreased_birth_body	0.91451561
73	MP0001119_abnormal_female_reproductive	0.90841980
74	MP0005171_absent_coat_pigmentation	0.90733536
75	MP0001299_abnormal_eye_distance/	0.90338534
76	MP0001697_abnormal_embryo_size	0.87770019
77	MP0002116_abnormal_craniofacial_bone	0.86130731
78	MP0003385_abnormal_body_wall	0.85691808
79	MP0005253_abnormal_eye_physiology	0.85099900
80	MP0001968_abnormal_touch/_nociception	0.83209209
81	MP0001986_abnormal_taste_sensitivity	0.82484740
82	MP0003115_abnormal_respiratory_system	0.81112182
83	MP0004215_abnormal_myocardial_fiber	0.80891181
84	MP0004145_abnormal_muscle_electrophysio	0.79889947
85	MP0002932_abnormal_joint_morphology	0.79026628
86	MP0005391_vision/eye_phenotype	0.78852728
87	MP0005187_abnormal_penis_morphology	0.78465556
88	MP0002210_abnormal_sex_determination	0.78042001
89	MP0002736_abnormal_nociception_after	0.77964649
90	MP0002751_abnormal_autonomic_nervous	0.77430692
91	MP0004197_abnormal_fetal_growth/weight/	0.74777502
92	MP0002115_abnormal_skeleton_extremities	0.74435895
93	MP0009672_abnormal_birth_weight	0.74021086
94	MP0003935_abnormal_craniofacial_develop	0.73639666
95	MP0001485_abnormal_pinna_reflex	0.73480428
96	MP0002734_abnormal_mechanical_nocicepti	0.73397221
97	MP0002177_abnormal_outer_ear	0.73102517
98	MP0003252_abnormal_bile_duct	0.71887754
99	MP0004272_abnormal_basement_membrane	0.71088341
100	MP0000383_abnormal_hair_follicle	0.70849907

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Colon cancer (HP:0003003)	6.82748993
2	Ependymoma (HP:0002888)	5.34903830
3	Volvulus (HP:0002580)	4.19765597
4	Submucous cleft hard palate (HP:0000176)	3.99936680
5	Bell-shaped thorax (HP:0001591)	3.54962147
6	Astrocytoma (HP:0009592)	3.54629479
7	Abnormality of the astrocytes (HP:0100707)	3.54629479
8	Chromosomal breakage induced by crosslinking agents (HP:0003221)	3.53755160
9	Agnosia (HP:0010524)	3.46356812
10	Glioma (HP:0009733)	3.31429223
11	Abnormality of the labia minora (HP:0012880)	3.28796853
12	Disproportionate short-trunk short stature (HP:0003521)	3.27670511
13	Rhabdomyosarcoma (HP:0002859)	3.09054646
14	Abnormality of the ileum (HP:0001549)	3.08999933
15	Embryonal renal neoplasm (HP:0011794)	3.06556062
16	Pancreatic islet-cell hyperplasia (HP:0004510)	2.96009379
17	Meckel diverticulum (HP:0002245)	2.94960812
18	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.87104288
19	Chromsome breakage (HP:0040012)	2.79791810
20	Medulloblastoma (HP:0002885)	2.73761777
21	Abnormality of chromosome stability (HP:0003220)	2.67884527
22	Abnormality of the preputium (HP:0100587)	2.56379982
23	True hermaphroditism (HP:0010459)	2.48701692
24	Long clavicles (HP:0000890)	2.46930843
25	Brushfield spots (HP:0001088)	2.38372613
26	Neoplasm of striated muscle (HP:0009728)	2.32073350
27	Tubulointerstitial nephritis (HP:0001970)	2.30867188
28	Abnormal gallbladder physiology (HP:0012438)	2.28303559
29	Cholecystitis (HP:0001082)	2.28303559
30	Intestinal atresia (HP:0011100)	2.27193409
31	Enlarged kidneys (HP:0000105)	2.25449824
32	Duodenal stenosis (HP:0100867)	2.25150290
33	Small intestinal stenosis (HP:0012848)	2.25150290
34	Poikiloderma (HP:0001029)	2.23100590
35	Abnormality of the duodenum (HP:0002246)	2.20925511
36	Clubbing of toes (HP:0100760)	2.19595600
37	Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)	2.19237851
38	Short 1st metacarpal (HP:0010034)	2.19237851
39	Breast carcinoma (HP:0003002)	2.19192380
40	Neoplasm of the adrenal gland (HP:0100631)	2.18742815
41	Abnormality of midbrain morphology (HP:0002418)	2.18475465
42	Molar tooth sign on MRI (HP:0002419)	2.18475465
43	Abnormality of endocrine pancreas physiology (HP:0012093)	2.18437725
44	Abnormality of the pancreatic islet cells (HP:0006476)	2.18437725
45	Birth length less than 3rd percentile (HP:0003561)	2.17241059
46	Shawl scrotum (HP:0000049)	2.17206371
47	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.12233044
48	Abnormality of alanine metabolism (HP:0010916)	2.12073633
49	Hyperalaninemia (HP:0003348)	2.12073633
50	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.12073633
51	Limb hypertonia (HP:0002509)	2.10511996
52	Pancreatic fibrosis (HP:0100732)	2.10020320
53	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.09214301
54	Nephroblastoma (Wilms tumor) (HP:0002667)	2.07552280
55	Fibular aplasia (HP:0002990)	2.07262096
56	Abnormality of the phalanges of the 2nd finger (HP:0009541)	2.03721026
57	Medial flaring of the eyebrow (HP:0010747)	2.03702753
58	Sloping forehead (HP:0000340)	2.03412244
59	Nephronophthisis (HP:0000090)	2.02473914
60	Pancreatic cysts (HP:0001737)	2.01782731
61	Hypoplastic iliac wings (HP:0002866)	1.99569290
62	Cortical dysplasia (HP:0002539)	1.97714803
63	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.96321150
64	Bifid tongue (HP:0010297)	1.93813294
65	Short tibia (HP:0005736)	1.93231516
66	Anencephaly (HP:0002323)	1.91124413
67	Abolished electroretinogram (ERG) (HP:0000550)	1.90312907
68	Cerebellar dysplasia (HP:0007033)	1.89944162
69	Hypoplastic ischia (HP:0003175)	1.89277459
70	Acute encephalopathy (HP:0006846)	1.89111372
71	Abnormality of the 1st metacarpal (HP:0010009)	1.88307197
72	Neoplasm of the oral cavity (HP:0100649)	1.88258319
73	Ectopic kidney (HP:0000086)	1.85937685
74	Triphalangeal thumb (HP:0001199)	1.83413085
75	Myelomeningocele (HP:0002475)	1.82126000
76	Neoplasm of the colon (HP:0100273)	1.81509858
77	Abdominal situs inversus (HP:0003363)	1.81312782
78	Abnormality of abdominal situs (HP:0011620)	1.81312782
79	Biliary tract neoplasm (HP:0100574)	1.80193184
80	Female pseudohermaphroditism (HP:0010458)	1.77164176
81	Absent radius (HP:0003974)	1.77131093
82	Acute necrotizing encephalopathy (HP:0006965)	1.75221610
83	Myelodysplasia (HP:0002863)	1.75213693
84	Aplasia/Hypoplasia of the fibula (HP:0006492)	1.74655256
85	Abnormality of methionine metabolism (HP:0010901)	1.74627083
86	Abnormality of the ischium (HP:0003174)	1.71764886
87	Absent thumb (HP:0009777)	1.69798003
88	Neoplasm of the adrenal cortex (HP:0100641)	1.68804027
89	Congenital primary aphakia (HP:0007707)	1.66052989
90	Unsteady gait (HP:0002317)	1.65248315
91	Absent forearm bone (HP:0003953)	1.65167100
92	Aplasia involving forearm bones (HP:0009822)	1.65167100
93	Abnormality of polysaccharide metabolism (HP:0011012)	1.63990643
94	Abnormality of glycosaminoglycan metabolism (HP:0004371)	1.63990643
95	Abnormality of mucopolysaccharide metabolism (HP:0011020)	1.63990643
96	Abnormality of serum amino acid levels (HP:0003112)	1.63850634
97	Abnormality of the carotid arteries (HP:0005344)	1.61426477
98	Gait imbalance (HP:0002141)	1.60879042
99	Breast aplasia (HP:0100783)	1.60823179
100	Mucopolysacchariduria (HP:0008155)	1.59914119

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ACVR1B	3.89669190
2	ADRBK2	3.74188494
3	BMPR1B	3.41687536
4	NUAK1	3.39205622
5	VRK2	3.20006570
6	PBK	2.98997937
7	TNIK	2.74824932
8	TAF1	2.64932774
9	TRIM28	2.57726154
10	TSSK6	2.52554887
11	PLK4	2.47771050
12	EIF2AK3	2.45489480
13	WNK3	2.42586391
14	PLK3	2.27463691
15	TGFBR1	2.24698387
16	BUB1	2.14042505
17	BRSK2	2.11802243
18	MKNK2	2.05503371
19	CDC7	2.00496005
20	FRK	1.91246223
21	BRD4	1.90251749
22	TTK	1.87642448
23	MAP4K2	1.85325604
24	MKNK1	1.85147256
25	FLT3	1.75468806
26	VRK1	1.73928313
27	MAP3K12	1.65237308
28	CSNK1G1	1.43425107
29	PLK2	1.35724129
30	ZAK	1.33209962
31	EIF2AK2	1.23982982
32	PKN2	1.14453234
33	STK3	1.10521488
34	PLK1	1.06184180
35	BRSK1	1.05173247
36	CLK1	1.04829007
37	PRKCI	1.02280269
38	STK38L	1.02101177
39	SMG1	1.00643441
40	MAPKAPK5	0.98583872
41	EIF2AK1	0.94558749
42	CHEK2	0.87997607
43	LATS1	0.86611204
44	SRPK1	0.86327168
45	MELK	0.81919237
46	NEK1	0.81786466
47	PAK2	0.79409398
48	CSNK1G2	0.78708528
49	PASK	0.77987884
50	WEE1	0.76585494
51	PNCK	0.75947993
52	CSNK1G3	0.74990008
53	ERBB3	0.71616800
54	DAPK1	0.69189158
55	NME1	0.67780053
56	GRK1	0.63638383
57	ATR	0.63506269
58	CAMKK2	0.63053372
59	STK4	0.62448894
60	FGFR1	0.55369585
61	DYRK2	0.54972749
62	AKT3	0.54685319
63	PINK1	0.53561013
64	MARK3	0.52288115
65	MAPKAPK3	0.49253337
66	ATM	0.48714902
67	CHEK1	0.45953958
68	CCNB1	0.45807451
69	AURKB	0.44732951
70	CSNK1A1L	0.43851965
71	MAPK13	0.43050744
72	LIMK1	0.38122937
73	SIK3	0.37940506
74	NLK	0.35898106
75	MYLK	0.35234380
76	GRK5	0.34638627
77	EPHB2	0.33938171
78	PKN1	0.32086768
79	BCR	0.31336458
80	ADRBK1	0.31139868
81	TLK1	0.31073338
82	CSNK1A1	0.31057812
83	KSR1	0.30034955
84	PRKCG	0.29156869
85	NTRK3	0.29028980
86	ROCK2	0.27227857
87	CDK7	0.27205339
88	PRKAA2	0.26644587
89	PRKDC	0.25317541
90	CDK9	0.25286541
91	STK11	0.24822281
92	PRKCE	0.24776357
93	YES1	0.24744077
94	CAMK2A	0.24640260
95	TIE1	0.24471171
96	MAP3K4	0.24033896
97	CDK1	0.23351849
98	TNK2	0.22775411
99	MINK1	0.20962947
100	FER	0.20809054

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Non-homologous end-joining_Homo sapiens_hsa03450	3.93568382
2	Mismatch repair_Homo sapiens_hsa03430	3.25479420
3	Proteasome_Homo sapiens_hsa03050	2.98688225
4	Fanconi anemia pathway_Homo sapiens_hsa03460	2.85492819
5	Protein export_Homo sapiens_hsa03060	2.63148619
6	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.52534422
7	Homologous recombination_Homo sapiens_hsa03440	2.28172095
8	Glycosaminoglycan degradation_Homo sapiens_hsa00531	2.23309995
9	RNA polymerase_Homo sapiens_hsa03020	2.23115258
10	Hedgehog signaling pathway_Homo sapiens_hsa04340	2.22110664
11	Steroid biosynthesis_Homo sapiens_hsa00100	2.21909276
12	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.03160110
13	Base excision repair_Homo sapiens_hsa03410	1.99155959
14	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.95474925
15	Basal cell carcinoma_Homo sapiens_hsa05217	1.92966776
16	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.87380938
17	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.86140089
18	Propanoate metabolism_Homo sapiens_hsa00640	1.85346104
19	RNA degradation_Homo sapiens_hsa03018	1.84248341
20	DNA replication_Homo sapiens_hsa03030	1.80490397
21	Selenocompound metabolism_Homo sapiens_hsa00450	1.76682896
22	Fatty acid elongation_Homo sapiens_hsa00062	1.69764939
23	RNA transport_Homo sapiens_hsa03013	1.68251152
24	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.64513111
25	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.57910934
26	Cell cycle_Homo sapiens_hsa04110	1.56670500
27	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.50161212
28	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.49925991
29	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.48571417
30	One carbon pool by folate_Homo sapiens_hsa00670	1.42566389
31	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.38209906
32	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.33848062
33	Nucleotide excision repair_Homo sapiens_hsa03420	1.32654002
34	Peroxisome_Homo sapiens_hsa04146	1.32646199
35	Purine metabolism_Homo sapiens_hsa00230	1.29928398
36	Pyruvate metabolism_Homo sapiens_hsa00620	1.25557395
37	Basal transcription factors_Homo sapiens_hsa03022	1.24102691
38	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.15785362
39	Sulfur metabolism_Homo sapiens_hsa00920	1.13151357
40	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.12732006
41	Regulation of autophagy_Homo sapiens_hsa04140	1.10613590
42	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.10592331
43	Phototransduction_Homo sapiens_hsa04744	1.07635997
44	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.04594760
45	Linoleic acid metabolism_Homo sapiens_hsa00591	1.04585638
46	Ether lipid metabolism_Homo sapiens_hsa00565	1.04193523
47	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.02036980
48	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.00775642
49	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.00157802
50	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.97304864
51	Glutathione metabolism_Homo sapiens_hsa00480	0.94263383
52	Pyrimidine metabolism_Homo sapiens_hsa00240	0.92670040
53	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.87921055
54	Parkinsons disease_Homo sapiens_hsa05012	0.84214340
55	Carbon metabolism_Homo sapiens_hsa01200	0.82260825
56	Spliceosome_Homo sapiens_hsa03040	0.80327470
57	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.79823536
58	mRNA surveillance pathway_Homo sapiens_hsa03015	0.78353755
59	Tryptophan metabolism_Homo sapiens_hsa00380	0.76599175
60	Butanoate metabolism_Homo sapiens_hsa00650	0.75859989
61	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.75789824
62	Metabolic pathways_Homo sapiens_hsa01100	0.72226821
63	Oxidative phosphorylation_Homo sapiens_hsa00190	0.71653152
64	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.71446274
65	Huntingtons disease_Homo sapiens_hsa05016	0.67134441
66	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.66914180
67	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.64289451
68	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.63897016
69	beta-Alanine metabolism_Homo sapiens_hsa00410	0.63522317
70	Oocyte meiosis_Homo sapiens_hsa04114	0.61371582
71	Lysine degradation_Homo sapiens_hsa00310	0.58957692
72	Nitrogen metabolism_Homo sapiens_hsa00910	0.57585524
73	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.57252784
74	Fatty acid metabolism_Homo sapiens_hsa01212	0.57135489
75	Retinol metabolism_Homo sapiens_hsa00830	0.54893272
76	Caffeine metabolism_Homo sapiens_hsa00232	0.51534537
77	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.51269393
78	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.50963768
79	Hippo signaling pathway_Homo sapiens_hsa04390	0.50651102
80	p53 signaling pathway_Homo sapiens_hsa04115	0.50043992
81	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.48759467
82	Fatty acid degradation_Homo sapiens_hsa00071	0.48710470
83	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.47080510
84	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.46758301
85	Fat digestion and absorption_Homo sapiens_hsa04975	0.46335320
86	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.46164449
87	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.43661597
88	Glycerolipid metabolism_Homo sapiens_hsa00561	0.42747703
89	Olfactory transduction_Homo sapiens_hsa04740	0.41981684
90	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.41908672
91	Wnt signaling pathway_Homo sapiens_hsa04310	0.39297229
92	Tyrosine metabolism_Homo sapiens_hsa00350	0.37835180
93	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.37360252
94	Mineral absorption_Homo sapiens_hsa04978	0.37102732
95	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.36575201
96	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.33804408
97	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.31426598
98	Arginine and proline metabolism_Homo sapiens_hsa00330	0.30439935
99	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.30412955
100	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.30056061

DNAJC19P6

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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